1. Antibacterial, remineralizing zinc oxide-doped phosphate-based glasses
- Author
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Genevieve Harris, Susan M. Higham, Sindhuja Rajadorai, Alistair Robinson, Sabeel P. Valappil, Norah Flannigan, Jonathan Roberts, Ensanya A. Abou Neel, EJ Miles, and Lee Cooper
- Subjects
Remineralisation ,Materials science ,Enamel paint ,Mechanical Engineering ,Doping ,chemistry.chemical_element ,Zinc ,Condensed Matter Physics ,Phosphate ,chemistry.chemical_compound ,chemistry ,Mechanics of Materials ,visual_art ,visual_art.visual_art_medium ,Degradation (geology) ,General Materials Science ,Growth inhibition ,Antibacterial activity ,Nuclear chemistry - Abstract
This study reports a novel melt quenched zinc oxide-doped phosphate-based glasses (Zn-PBGs) of varying CaO mol% designated as C11, C12, C13. The glass degradation rate, ions release, antibacterial activity against S. mutans and remineralization potential were investigated. Zn-PBGs showed one order of magnitude higher degradation rate than Zn-free PBG. The highest rate was observed for C11; Na+, Ca2+, Zn2+ and P5+ release followed the same trend. The higher the Zn2+ release, the greater the S. mutans growth inhibition. C11 showed significantly lower mineral loss from enamel than positive and negative controls. Zn-PBGs could be used to reverse enamel demineralization.
- Published
- 2022
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