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2. Advancing respiratory virus diagnostics: integrating the nasal IFN-I score for improved viral detection

Author

Mommert-Tripon, Marine, Parraud, Delphine, Grosbois, Cloé, Gaymard, Alexandre, Cheynet, Valérie, Lina, Bruno, Oriol, Guy, Laurent, Frédéric, Dupré, Caroline, Semanas, Quentin, Bal, Antonin, Generenaz, Laurence, Pons, Sylvie, Brengel-Pesce, Karen, Guichard, Audrey, Mouton, William, Morfin, Florence, Fleurie, Aurore, and Trouillet-Assant, Sophie

Published
2024
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3. Critical COVID-19 Unveils the Link between Viral Particle Blood Dissemination and Prolonged Type I Interferon

Author

Saker, Kahina, primary, Mommert, Marine, additional, Oriol, Guy, additional, Generenaz, Laurence, additional, Cheynet, Valérie, additional, Bal, Antonin, additional, Bastard, Paul, additional, Casanova, Jean Laurent, additional, Roux, Emmanuel, additional, Brengel-Pesce, Karen, additional, Fleurie, Aurore, additional, Pons, Sylvie, additional, Barnel, Cécile, additional, Mokdad, Bouchra, additional, Wallet, Florent, additional, Terrier, Olivier, additional, Richard, Jean-Christophe, additional, and Assant, Sophie, additional

Published
2024
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4. Performance of 11 Host Biomarkers Alone or in Combination in the Diagnosis of Late-Onset Sepsis in Hospitalized Neonates: The Prospective EMERAUDE Study

Author

Pons, Sylvie, primary, Trouillet-Assant, Sophie, additional, Subtil, Fabien, additional, Abbas-Chorfa, Fatima, additional, Cornaton, Elise, additional, Berthiot, Amélie, additional, Galletti, Sonia, additional, Plat, Aurélie, additional, Rapin, Stephanie, additional, Trapes, Laurene, additional, Generenaz, Laurence, additional, Brengel-Pesce, Karen, additional, Callies, Arnaud, additional, Plaisant, Franck, additional, Claris, Olivier, additional, Portefaix, Aurelie, additional, Flamant, Cyril, additional, and Butin, Marine, additional

Published
2023
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5. Determinants of protection against SARS-CoV-2 Omicron BA.1 and Delta infections in fully vaccinated outpatients

Author

Roy, Alvaro, primary, Saade, Carla, additional, Josset, Laurence, additional, Clément, Bénédicte, additional, Morfin, Florence, additional, Destras, Grégory, additional, Valette, Martine, additional, Icard, Vinca, additional, Oblette, Antoine, additional, Debombourg, Marion, additional, Garrigou, Christine, additional, Brengel-Pesce, Karen, additional, Generenaz, Laurence, additional, Saker, Kahina, additional, Hernu, Romain, additional, Pozzetto, Bruno, additional, Lina, Bruno, additional, Trabaud, Mary-Anne, additional, Trouillet-Assant, Sophie, additional, and Bal, Antonin, additional

Published
2023
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6. Towards a Universal Marker of Ongoing Respiratory Viral Infections Based on Nasal Host Response

Author

Mommert, Marine, primary, Parraud, Delphine, additional, Grosbois, Cloé, additional, Gaymard, Alexandre, additional, Cheynet, Valérie, additional, Lina, Bruno, additional, Oriol, Guy, additional, Generenaz, Laurence, additional, Pons, Sylvie, additional, Fleurie, Aurore, additional, Guichard, Audrey, additional, Mouton, William, additional, Morfin-Sherpa, Florence, additional, Brengel-Pesce, Karen, additional, and Trouillet-Assant, Sophie, additional

Published
2023
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7. Performance of 11 host biomarkers alone or in combination in the diagnosis of late-onset sepsis in hospitalized neonates: the prospective EMERAUDE study

Author

Pons, Sylvie, primary, Trouillet-Assant, Sophie, additional, Subtil, Fabien, additional, Abbas-Chorfa, Fatima, additional, Cornaton, Elise, additional, Berthiot, Amélie, additional, Galletti, Sonia, additional, Plat, Aurelie, additional, Rapin, Stephanie, additional, Trapes, Laurene, additional, Generenaz, Laurence, additional, Brengel-Pesce, Karen, additional, Callies, Arnaud, additional, Plaisant, Franck, additional, Claris, Olivier, additional, Portefaix, Aurelie, additional, Flamant, Cyril, additional, and Butin, Marine, additional

Published
2022
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8. Performance Evaluation of Host Biomarker Combinations for the Diagnosis of Serious Bacterial Infection in Young Febrile Children: A Double-Blind, Multicentre, Observational Study

Author

Portefaix, Aurélie, primary, Pons, Sylvie, additional, Ouziel, Antoine, additional, Basmaci, Romain, additional, Rebaud, Philippe, additional, Delafay, Marie-Caroline, additional, Generenaz, Laurence, additional, Oriol, Guy, additional, Meunier, Boris, additional, Abbas-Chorfa, Fatima, additional, Trouillet-Assant, Sophie, additional, Ginhoux, Tiphanie, additional, Subtil, Fabien, additional, Gillet, Yves, additional, Brengel-Pesce, Karen, additional, and Javouhey, Etienne, additional

Published
2022
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9. Determinants of protection against SARS‐CoV‐2 Omicron BA.1 and Delta infections in fully vaccinated outpatients.

Author

Roy, Alvaro, Saade, Carla, Josset, Laurence, Clément, Bénédicte, Morfin, Florence, Destras, Grégory, Valette, Martine, Icard, Vinca, Billaud, Geneviéve, Oblette, Antoine, Debombourg, Marion, Garrigou, Christine, Brengel‐Pesce, Karen, Generenaz, Laurence, Saker, Kahina, Hernu, Romain, Pozzetto, Bruno, Lina, Bruno, Trabaud, Mary‐Anne, and Trouillet‐Assant, Sophie

Subjects
SARS-CoV-2 Omicron variant, SARS-CoV-2, PEPTIDES, VACCINATION, OUTPATIENTS
Abstract

We aimed to evaluate the association between the humoral and cellular immune responses and symptomatic SARS‐CoV‐2 infection with Delta or Omicron BA.1 variants in fully vaccinated outpatients. Anti‐receptor binding domain (RBD) IgG levels and interferon‐gamma (IFN‐γ) release were evaluated at PCR‐diagnosis of SARS‐CoV‐2 in 636 samples from negative and positive patients during Delta and Omicron BA.1 periods. Median levels of anti‐RBD IgG in positive patients were significantly lower than in negative patients for both variants (p < 0.05). The frequency of Omicron BA.1 infection in patients with anti‐RBD IgG concentrations ≥1000 binding antibody units (BAU)/mL was 51.0% and decreased to 34.4% in patients with concentrations ≥3000 BAU/mL. For Delta infection, the frequency of infection was significantly lower when applying the same anti‐RBD IgG thresholds (13.3% and 5.3% respectively, p < 0.05). In addition, individuals in the hybrid immunity group had a 4.5 times lower risk of Delta infection compared to the homologous vaccination group (aOR = 0.22, 95% CI: [0.05−0.64]. No significant decrease in the risk of Omicron BA.1 infection was observed in the hybrid group compared to the homologous group, but the risk decreased within the hybrid group as anti‐RBD IgG titers increased (aOR = 0.08, 95% CI: [0.01−0.41], p = 0.008). IFN‐γ release post‐SARS‐CoV‐2 peptide stimulation was not different between samples from patients infected (either with Delta or Omicron BA.1 variant) or not (p > 0.05). Our results show that high circulating levels of anti‐RBD IgG and hybrid immunity were independently associated with a lower risk of symptomatic SARS‐CoV‐2 infection in outpatients with differences according to the infecting variant (www.clinicaltrials.gov; ID NCT05060939). [ABSTRACT FROM AUTHOR]

Published
2023
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10. Dynamics of viral shedding during ancestral or Omicron BA.1 SARS-CoV-2 infection and enhancement of pre-existing immunity during breakthrough infections

Author

Saade, Carla, primary, Brengel-Pesce, Karen, additional, Gaymard, Alexandre, additional, Trabaud, Mary-Anne, additional, Destras, Gregory, additional, Oriol, Guy, additional, Cheynet, Valérie, additional, Debombourg, Marion, additional, Mokdad, Bouchra, additional, Billaud, Geneviève, additional, Oblette, Antoine, additional, Créhalet, Hervé, additional, Giannoli, Jean-Marc, additional, Garrigou, Christine, additional, Generenaz, Laurence, additional, Compagnon, Christelle, additional, Boibieux, André, additional, Lina, Bruno, additional, Morfin, Florence, additional, Pozzetto, Bruno, additional, Josset, Laurence, additional, Trouillet Assant, Sophie, additional, and Bal, Antonin, additional

Published
2022
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11. Type I IFN immunoprofiling in COVID-19 patients

Author

Mouton, William, Oriol, Guy, Compagnon, Christelle, Generenaz, Laurence, Cheynet, Valérie, Ader, Florence, Becker, Agathe, Benech, Nicholas, Chauvelot, Pierre, Chidiac, Christian, Conrad, Anne, Ferry, Tristan, Miailhes, Patrick, Perpoint, Thomas, Perry, Marielle, Pouderoux, Cécile, Roux, Sandrine, Triffault-Fillit, Claire, Valour, Florent, Hodane, Yonis, Chauvelot, Louis, Chabert, Paul, Provoost, Judith, David, Guillaume, Folliet, Laure, Lecam, Pierre, Billaud, Geneviève, Bouscambert, Maude, Escuret, Vanessa, Frobert, Emilie, Bal, Antonin, Destras, Grégory, Josset, Laurence, Morfin, Florence, Munier, Clément, Valette, Martine, Venet, Fabienne, Garnier, Lorna, Pescarmona, Rémi, Lombard, Christine, Walzer, Thierry, Trouillet-Assant, Sophie, Viel, Sebastien, Gaymard, Alexandre, Pons, Sylvie, Richard, Jean-Christophe, Perret, Magali, Villard, Marine, Brengel-Pesce, Karen, Lina, Bruno, Mezidi, Mehdi, Bitker, Laurent, and Belot, Alexandre

Published
2020
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12. Type I IFN immunoprofiling in COVID-19 patients

Author

Trouillet-Assant, Sophie, primary, Viel, Sebastien, additional, Gaymard, Alexandre, additional, Pons, Sylvie, additional, Richard, Jean-Christophe, additional, Perret, Magali, additional, Villard, Marine, additional, Brengel-Pesce, Karen, additional, Lina, Bruno, additional, Mezidi, Mehdi, additional, Bitker, Laurent, additional, Belot, Alexandre, additional, Mouton, William, additional, Oriol, Guy, additional, Compagnon, Christelle, additional, Generenaz, Laurence, additional, Cheynet, Valérie, additional, Ader, Florence, additional, Becker, Agathe, additional, Benech, Nicholas, additional, Chauvelot, Pierre, additional, Chidiac, Christian, additional, Conrad, Anne, additional, Ferry, Tristan, additional, Miailhes, Patrick, additional, Perpoint, Thomas, additional, Perry, Marielle, additional, Pouderoux, Cécile, additional, Roux, Sandrine, additional, Triffault-Fillit, Claire, additional, Valour, Florent, additional, Hodane, Yonis, additional, Chauvelot, Louis, additional, Chabert, Paul, additional, Provoost, Judith, additional, David, Guillaume, additional, Folliet, Laure, additional, Lecam, Pierre, additional, Billaud, Geneviève, additional, Bouscambert, Maude, additional, Escuret, Vanessa, additional, Frobert, Emilie, additional, Bal, Antonin, additional, Destras, Grégory, additional, Josset, Laurence, additional, Morfin, Florence, additional, Munier, Clément, additional, Valette, Martine, additional, Venet, Fabienne, additional, Garnier, Lorna, additional, Pescarmona, Rémi, additional, Lombard, Christine, additional, and Walzer, Thierry, additional

Published
2020
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13. Performance Assessment of SARS-CoV-2 PCR Assays Developed by WHO Referral Laboratories

Author

Etievant, Sibyle, primary, Bal, Antonin, additional, Escuret, Vanessa, additional, Brengel-Pesce, Karen, additional, Bouscambert, Maude, additional, Cheynet, Valérie, additional, Generenaz, Laurence, additional, Oriol, Guy, additional, Destras, Gregory, additional, Billaud, Geneviève, additional, Josset, Laurence, additional, Frobert, Emilie, additional, Morfin, Florence, additional, and Gaymard, Alexandre, additional

Published
2020
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14. Sensitivity assessment of SARS-CoV-2 PCR assays developed by WHO referral laboratories

Author

Etievant, Sibyle, primary, Bal, Antonin, additional, Escuret, Vanessa, additional, Brengel–Pesce, Karen, additional, Bouscambert, Maude, additional, Cheynet, Valérie, additional, Generenaz, Laurence, additional, Oriol, Guy, additional, Destras, Gregory, additional, Billaud, Geneviève, additional, Josset, Laurence, additional, Frobert, Emilie, additional, Morfin, Florence, additional, and Gaymard, Alexandre, additional

Published
2020
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15. Metagenomic Investigation of Torque Teno Mini Virus-SH in Hematological Patients

Author

Bal, Antonin, primary, Oriol, Guy, additional, Josset, Laurence, additional, Generenaz, Laurence, additional, Sarkozy, Clémentine, additional, Sesques, Pierre, additional, Salles, Gilles, additional, Morfin, Florence, additional, Lina, Bruno, additional, Becker, Jérémie, additional, Reynier, Frédéric, additional, Mallet, François, additional, Pachot, Alexandre, additional, Cheynet, Valérie, additional, Brengel-Pesce, Karen, additional, and Trouillet-Assant, Sophie, additional

Published
2019
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