Search

Your search keyword '"Generali, Elena"' showing total 189 results
Start Over Author "Generali, Elena"
189 results on '"Generali, Elena"'

1. The long Pentraxin PTX3 serves as an early predictive biomarker of co-infections in COVID-19

Author

Accornero, Stefano, Aghemo, Alessio, Ali, Hussam, Angelini, Claudio, Arcari, Ivan, Arosio, Paola, Azzolini, Elena, Baccarin, Alessandra, Badalamenti, Salvatore, Baggio, Sara, Barbagallo, Michela, Barberi, Caterina, Barbic, Franca, Barbieri, Viviana, Barbone, Alessandro, Basciu, Alessio, Bocciolone, Monica, Borea, Federica, Borroni, Mario, Bresciani, Gianluigi, Brunetta, Enrico, Bulletti, Cinzia, Cadonati, Cristina, Calabro', Lorenzo, Calatroni, Marta, Calvetta Albania, Antonietta, Cannata, Francesco, Canziani, Lorenzo, Capretti Giovanni, Luigi, Carlani, Elisa, Carrone, Flaminia, Casana, Maddalena, Cecconi, Maurizio, Ceriotti, Carlo, Ciccarelli, Michele, Cimino, Matteo, Ciuffini, Leonardo, Colaizzi, Chiara, Colapietro, Francesca, Costa, Guido, Cozzi, Ottavia, Craviotto, Vincenzo, Crespi, Chiara, Crippa, Massimo, Da Rio, Leonardo, Dal Farra, Sara, D'Antonio, Federica, De Ambroggi, Guido, De Donato, Massimo, De Lucia, Francesca, De Santis, Maria, Delle Rose, Giacomo, Di Pilla, Marina, Dipaola, Franca, Dipasquale, Andrea, Dipasquale, Angelo, Droandi, Ginevra, Fazio, Roberta, Ferrante, Giuseppe, Ferrara Elisa, Chiara, Ferrari Matteo, Carlo, Ferri, Sebastian, Folci, Marco, Foresti, Sara, Franchi, Eloisa, Fraolini, Elia, Fugazza, Alessandro, Furfaro, Federica, Galimberti, Paola, Galtieri Alessia, Piera, Gavazzi, Francesca, Generali, Elena, Goletti, Benedetta, Guidelli, Giacomo, Jacobs, Flavia, Kurihara, Hayato, Lagioia, Michele, Libre', Luca, Lleo, Ana, Loiacono, Ferdinando, Lughezzani, Giovanni, Maccallini, Marta, Maiorino Alfonso, Francesco, Malesci, Alberto, Mantovani, Riccardo, Marchettini, Davide, Marinello, Arianna, Markopoulos, Nikolaos, Masetti, Chiara, Milani, Angelo, Mirani, Marco, Morelli, Paola, Motta, Francesca, Mundula, Valeria, Nigro, Mattia, Omodei, Paolo, Ormas, Monica, Pagliaro, Arianna, Paliotti, Roberta, Parigi Tommaso, Lorenzo, Pedale, Rosa, Pegoraro, Francesco, Pellegatta, Gaia, Pellegrino, Marta, Petriello, Gennaro, Piccini, Sara, Pocaterra, Daria, Poliani, Laura, Preatoni, Paoletta, Procopio, Fabio, Puggioni, Francesca, Pugliese, Luca, Racca, Francesca, Randazzo, Michele, Regazzoli Lancini, Damiano, Reggiani, Francesco, Rodolfi, Stefano, Ruongo, Lidia, Sacco, Clara, Sandri Maria, Teresa, Savi, Marzia, Scarfo', Iside, Shiffer, Dana, Sicoli, Federico, Solano, Simone, Solitano, Virginia, Stainer, Anna, Stella Matteo, Carlo, Strangio, Giuseppe, Taormina, Antonio, Testoni, Lucia, Tordato, Federica, Trabucco, Angela, Ulian, Luisa, Valentino, Rossella, Valeriano, Chiara, Vena, Walter, Verlingieri, Simona, Vespa, Edoardo, Voza, Antonio, Zanuso, Valentina, Zilli, Alessandra, Anfray, Clement, Belgiovine, Cristina, Bertocchi, Alice, Bombace, Sara, Brescia, Paola, Calcaterra, Francesca, Calvi, Michela, Cancellara, Assunta, Capucetti, Arianna, Carenza, Claudia, Carloni, Sara, Carnevale, Silvia, Cazzetta, Valentina, Coianiz, Nicolò, Darwich, Abbass, Davoudian, Sadaf, De Paoli, Federica, Di Donato, Rachele, Digifico, Elisabeth, Durante, Barbara, Farina Floriana, Maria, Ferrari, Valentina, Fornasa, Giulia, Franzese, Sara, Ghasemi, Somayehsadat, Gil Gomez, Antonio, Giugliano, Silvia, Gomes Ana, Rita, Lizier, Michela, Lo Cascio, Antonino, Melacarne, Alessia, Mozzarelli, Alessandro, My, Ilaria, Oresta, Bianca, Pasqualini, Fabio, Pastò, Anna, Pelamatti, Erica, Perucchini, Chiara, Pozzi, Chiara, Rimoldi, Valeria, Rimoldi, Monica, Scarpa, Alice, Scavello, Francesco, Silvestri, Alessandra, Sironi, Marina, Spadoni, Ilaria, Spano', Salvatore, Spata, Gianmarco, Supino, Domenico, Tentorio, Paolo, Ummarino, Aldo, Valentino, Sonia, Zaghi, Elisa, Zanon, Veronica, Mapelli, Sarah N., Nappi, Emanuele, García Martín, Ian David, Leone, Roberto, Angelotti, Giovanni, Zhong, Hang, Magrini, Elena, Stravalaci, Matteo, Protti, Alessandro, Santini, Alessandro, Costantini, Elena, Savevski, Victor, Bottazzi, Barbara, Bartoletti, Michele, Mantovani, Alberto, and Garlanda, Cecilia

Published
2024
Full Text
View/download PDF

2. Negative prognostic impact of electrolyte disorders in patients hospitalized for Covid-19 in a large multicenter study

Author

Genovesi, Simonetta, Regolisti, Giuseppe, Rebora, Paola, Occhino, Giuseppe, Belli, Michele, Molon, Giulio, Citerio, Giuseppe, Beltrame, Anna, Maloberti, Alessandro, Generali, Elena, Giannattasio, Cristina, Epis, Oscar Massimiliano, Rossetti, Claudio, Bellelli, Giuseppe, De Nalda, Ana Lleo, Capua, Ilaria, and Valsecchi, Maria Grazia

Published
2023
Full Text
View/download PDF

3. Prevalence and predictive value of disease specific autoantibodies over 13 years in a large cohort representative of the general population of northern Italy

Author

Generali, Elena

Subjects
616.97
Abstract

Autoimmune diseases represent chronic disorders that affect a significant proportion of the population in Europe, with a impact on patients’ quality of life and socioeconomic costs for the healthcare system and community. Virtually, all autoimmune diseases are associated with the presence of serum autoantibodies. After the preclinical period, clinical manifestations develop, and a delay in the diagnosis and treatment can account for further organ damage, physical and psychological disability that cause a reduction of the working capacity and finally a high economic impact on society. Based on these findings, we aimed to: 1. Estimate the prevalence of disease specific autoantibodies in the general population of an area of Lombardia region by using the most recently developed methods for the detection of autoantibodies. 2. Analyze the autoantibodies predictive value for the development of autoimmune diseases over 15 years of follow-up. 3. Analyze if there are factors at baseline that can predict the development of autoimmune disease over 15 years of follow-up, in order to identify patients at higher risk of developing an autoimmune disease that need a closer follow-up. 4. Analyze the autoantibodies predictive value for the development of malignancies over 15 years of follow-up. Research design and methodology The present study was conducted on two different cohorts derived from the general population of Lombardia region in Northern Italy: ISOLA (2,828 subjects) and CA.ME.LI.A. (CArdiovascular risk, MEtabolic syndrome, LIver, and Autoimmunity) (1,712 subjects). Serum samples were tested for serum autoantibodies (ANA, anti-ENA, rheumatoid factor, anti-CCP, anti-phospholipid antibodies, AMA, anti-LKM, anti-LC1, anti-SLA, anti-DGP, anti-tTG) using the most innovative techniques. Autoimmune diseases diagnosis were researched analyzing the administrative health databases. Furthermore, we detected hospitalization, cancer diagnosis, and death. In the CA.ME.LI.A. cohort cardiovascular risk factors were analyzed and 1/3 underwent carotid ultrasonographic analysis. In summary, we report that: 1. Serum ANA are detected in up to 18% of the general population, being more frequent in women and in elder ages while being ANA associated with an higher risk of connective tissue disease development 2. Serum rheumatoid factor is detected in 8.1% of the general population, while serum anti-CCP are found in 4.8% of the population, the prevalence of double positivity is 0.6%.Anti-CCP are associated with a significant increased risk of RA development, while rheumatoid factor is associated with both HBV and HCV infection. Anti-CCP are associated with an increased risk of cancer and rheumatoid factor is associated with an increased risk of death. 3. Anti-phospholipid antibodies are detected in 15% of an unselected population, especially newly identified autoantibodies not currently included in the classification criteria. Anti-phospholipid antibodies are associated with an increased cardiovascular risk profile and independently with cardiovascular disease, especially subclinical atherosclerosis. 4. AMA are detected in 3.8%, but at high titer in 1% of an unselected population; we identified only two cases of PBC, of which only one was AMA positive therefore we cannot estimate the risk; anti-LKM, anti-SLA, anti-LC1 antibodies are rarely found. 5. Anti-DPG antibodies are detected in 1.85% of an unselected population, while, anti-tTG were found in 2.2%, with no differences between sexes. We identified 7 cases of coeliac disease, of which only one resulted positive for both anti-DPG and anti-tTG antibodies at high-titer. In conclusion, autoantibodies are frequently found in subjects randomly selected from the general population, while being only seldom associated with an increased risk of developing an overt autoimmune disease. Furthermorre, autoantibodies may be associated with predisposing factors, as viral infections or cancer.

Published
2020
Full Text
View/download PDF

5. Geographical heterogeneity of clinical and serological phenotypes of systemic sclerosis observed at tertiary referral centres. The experience of the Italian SIR-SPRING registry and review of the world literature

Author

Ferri, Clodoveo, De Angelis, Rossella, Giuggioli, Dilia, Bajocchi, Gianluigi, Dagna, Lorenzo, Zanframundo, Giovanni, Foti, Rosario, Cacciapaglia, Fabio, Cuomo, Giovanna, Ariani, Alarico, Rosato, Edoardo, Guiducci, Serena, Girelli, Francesco, Riccieri, Valeria, Zanatta, Elisabetta, Bosello, Silvia, Cavazzana, Ilaria, Ingegnoli, Francesca, De Santis, Maria, Murdaca, Giuseppe, Abignano, Giuseppina, Romeo, Nicoletta, Della Rossa, Alessandra, Caminiti, Maurizio, Iuliano, Annamaria, Ciano, Giovanni, Beretta, Lorenzo, Bagnato, Gianluca, Lubrano, Ennio, De Andres, Ilenia, Giollo, Alessandro, Saracco, Marta, Agnes, Cecilia, Lumetti, Federica, Spinella, Amelia, Magnani, Luca, Campochiaro, Corrado, De Luca, Giacomo, Codullo, Veronica, Visalli, Elisa, Masini, Francesco, Gigante, Antonietta, Bellando-Randone, Silvia, Pellegrino, Greta, Pigatto, Erika, Lazzaroni, Maria Grazia, Franceschini, Franco, Generali, Elena, Mennillo, Gianna, Barsotti, Simone, Mariano, Giuseppa Pagano, Calabrese, Francesca, Furini, Federica, Vultaggio, Licia, Parisi, Simone, Peroni, Clara Lisa, Rozza, Davide, Zanetti, Anna, Carrara, Greta, Landolfi, Giampiero, Scirè, Carlo Alberto, Bianchi, Gerolamo, Fusaro, Enrico, Sebastiani, Gian Domenico, Govoni, Marcello, D'Angelo, Salvatore, Cozzi, Franco, Doria, Andrea, Iannone, Florenzo, Salvarani, Carlo, and Matucci-Cerinic, Marco

Published
2022
Full Text
View/download PDF

6. Systemic sclerosis sine scleroderma: clinical and serological features and relationship with other cutaneous subsets in a large series of patients from the national registry ‘SPRING’ of the Italian Society for Rheumatology

Author

Carlo Alberto Scirè, Andrea Doria, Marcello Govoni, Gerolamo Bianchi, Marco Matucci-Cerinic, Florenzo Iannone, Ennio Lubrano, Corrado Campochiaro, Veronica Codullo, Alessandra Della Rossa, Gemma Lepri, Elisabetta Zanatta, Beretta Lorenzo, Doria Andrea, Lepri Gemma, Lorenzo Beretta, Greta Carrara, Alarico Ariani, Simone Parisi, Marta Saracco, Francesco Girelli, Maria De Santis, Federica Lumetti, Dilia Giuggioli, Enrico Fusaro, Simone Barsotti, Ilaria Cavazzana, Federica Furini, Carlo Salvarani, Serena Guiducci, Franco Cozzi, Valeria Riccieri, Francesca Ingegnoli, Edoardo Rosato, Antonietta Gigante, Rosario Foti, Elisa Visalli, Fabio Cacciapaglia, Lorenzo Dagna, Franco Franceschini, Silvia Bellando-Randone, Giovanna Cuomo, Gianluigi Bajocchi, Alessandro Giollo, Giacomo De Luca, Giuseppina Abignano, Carlo Sciré, Anna Zanetti, Giovanni Zanframundo, Edoardo Cipolletta, Silvia Laura Bosello, Clodoveo Ferri, Amelia Spinella, Giuseppa Pagano Mariano, Maurizio Caminiti, Giuseppe Murdaca, Salvatore D'Angelo, Gianpiero Landolfi, Nicoletta Romeo, Gian Domenico Sebastiani, Erika Pigatto, Rossella De Angelis, Davide Rozza, Maria-Grazia Lazzaroni, Anna Maria Iuliano, Giovanni Ciano, Gianluca Bagnato, Ilenia De Andres, Cecilia Agnes, Luca Magnani, Claudio Di Vico, Greta Pellagrino, Elena Generali, Gianna Mennillo, Licia Vultaggio, Clara Lisa Peroni, Abignano Giuseppina, Agnes Cecilia, Amato Giorgio, Ariani Alarico, Bagnato Gianluca, Bajoicchi Gianluigi, Barsotti Simone, Bellando-Randone Silvia, Benenati Alessia, Bianchi Gerolamo, Bosello Silvia, Cacciapaglia Fabio, Calabrese Francesca, Caminiti Maurizio, Campochiaro Corrado, Carignola Renato, Ciano Giovanni, Cipolletta Edoardo, Codullo Veronica, Cozzi Franco, Cuomo Giovanna, D’Angelo Salvatore, Dagna Lorenzo, Dall’Ara Francesca, De Andres Ilenia, De Angelis Rossella, De Cata Angelo, De Luca Giacomo, De Santis Maria, Della Rossa Alessandra, Di Vico Claudio, Doveri Marica, Foti Rosario, Furini Federica, Fusaro Enrico, Generali Elena, Gigante Antonietta, Giollo Alessandro, Girelli Francesco, Giuggioli Dilia, Govoni Marcello, Guiducci Serena, Iannone Florenzo, Ingegnoli Francesca, Iuliano Anna Maria, Lazzaroni Maria Grazia, Lubrano Ennio, Lumetti Federica, Magnani Luca, Mennillo Gianna, Murdaca Giuseppe Ospedale, Pagano Mariano Giuseppa, Parisi Simone, Pellegrino Greta, Peroni Clara Lisa, Pigatto Erika, Riccieri Valeria, Romeo Nicoletta, Rosato Edoardo, Sambataro Gianluca, Saracco Marta, Sebastiani Giandomenico, Spinella Amelia, Talotta Rossella, Visalli Elisa, Vultaggio Licia, Zanatta Elisabetta, and Zanframundo Giovanni

Subjects
Medicine
Abstract

Objective To describe demographic, clinical and laboratory features of systemic sclerosis sine scleroderma (ssSSc) in a large multicentre systemic sclerosis (SSc) cohort.Methods Data involving 1808 SSc patients from Italian Systemic sclerosis PRogression INvestiGation registry were collected. The ssSSc was defined by the absence of any cutaneous sclerosis and/or puffy fingers. Clinical and serological features of ssSSc were compared with limited cutaneous (lcSSc) and diffuse cutaneous (dcSSc) subsets.Results Among patients with SSc, only 61 (3.4%) were classified as having ssSSc (F/M=19/1). Time from Raynaud’s phenomenon (RP) onset to diagnosis was longer in ssSSc (3 years, IQR 1–16.5) than lcSSc (2 years, IQR 0–7), and dcSSc (1 year, IQR 0–3) (p

Published
2023
Full Text
View/download PDF

7. Long-term Outcome of Children Born to Women with Autoimmune Rheumatic Diseases: A Multicentre, Nationwide Study on 299 Randomly Selected Individuals

Author

Andreoli, Laura, Nalli, Cecilia, Lazzaroni, Maria Grazia, Carini, Chiara, Dall’Ara, Francesca, Reggia, Rossella, Rodrigues, Marília, Benigno, Carolina, Baldissera, Elena, Bartoloni, Elena, Basta, Fabio, Bellisai, Francesca, Bortoluzzi, Alessandra, Campochiaro, Corrado, Cantatore, Francesco Paolo, Caporali, Roberto, Ceribelli, Angela, Chighizola, Cecilia B., Conigliaro, Paola, Corrado, Addolorata, Cutolo, Maurizio, D’Angelo, Salvatore, De Stefani, Elena, Doria, Andrea, Favaro, Maria, Fischetti, Colomba, Foti, Rosario, Gabrielli, Armando, Generali, Elena, Gerli, Roberto, Gerosa, Maria, Larosa, Maddalena, Maier, Armin, Malavolta, Nazzarena, Meroni, Marianna, Meroni, Pier Luigi, Montecucco, Carlomaurizio, Mosca, Marta, Padovan, Melissa, Paolazzi, Giuseppe, Pazzola, Giulia, Peccatori, Susanna, Perricone, Roberto, Pettiti, Giorgio, Picerno, Valentina, Prevete, Immacolata, Ramoni, Véronique, Romeo, Nicoletta, Ruffatti, Amelia, Salvarani, Carlo, Sebastiani, Gian Domenico, Selmi, Carlo, Serale, Francesca, Sinigaglia, Luigi, Tani, Chiara, Trevisani, Marica, Vadacca, Marta, Valentini, Eleonora, Valesini, Guido, Visalli, Elisa, Vivaldelli, Ester, Zuliani, Lucia, and Tincani, Angela

Published
2022
Full Text
View/download PDF

9. “Disease knowledge index” and perspectives on reproductive issues: A nationwide study on 398 women with autoimmune rheumatic diseases

Author

Andreoli, Laura, Lazzaroni, Maria Grazia, Carini, Chiara, Dall’Ara, Francesca, Nalli, Cecilia, Reggia, Rossella, Rodrigues, Marília, Benigno, Carolina, Baldissera, Elena, Bartoloni-Bocci, Elena, Basta, Fabio, Bellisai, Francesca, Bortoluzzi, Alessandra, Campochiaro, Corrado, Cantatore, Francesco Paolo, Caporali, Roberto, Ceribelli, Angela, Chighizola, Cecilia B., Conigliaro, Paola, Corrado, Addolorata, Cutolo, Maurizio, D’Angelo, Salvatore, De Stefani, Elena, Doria, Andrea, Favaro, Maria, Fischetti, Colomba, Foti, Rosario, Gabrielli, Armando, Generali, Elena, Gerli, Roberto, Gerosa, Maria, Larosa, Maddalena, Maier, Armin, Malavolta, Nazzarena, Meroni, Marianna, Meroni, Pier Luigi, Montecucco, Carlomaurizio, Mosca, Marta, Padovan, Melissa, Paolazzi, Giuseppe, Pazzola, Giulia, Peccatori, Susanna, Perricone, Roberto, Pettiti, Giorgio, Picerno, Valentina, Prevete, Immacolata, Ramoni, Véronique, Romeo, Nicoletta, Ruffatti, Amelia, Salvarani, Carlo, Sebastiani, Gian Domenico, Selmi, Carlo, Serale, Francesca, Sinigaglia, Luigi, Tani, Chiara, Trevisani, Marica, Vadacca, Marta, Valentini, Eleonora, Valesini, Guido, Visalli, Elisa, Vivaldelli, Ester, Zuliani, Lucia, and Tincani, Angela

Published
2019
Full Text
View/download PDF

10. Immune-Mediated Heart Disease

Author

Generali, Elena, Folci, Marco, Selmi, Carlo, Riboldi, Piersandro, COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, Sattler, Susanne, editor, and Kennedy-Lydon, Teresa, editor

Published
2017
Full Text
View/download PDF

14. List of Contributors

Author

Afek, Arnon, primary, Afeltra, Antonella, additional, Afflitto, Gabriele Gallo, additional, Alessandri, Cristiano, additional, Alivernini, Stefano, additional, Alunno, Alessia, additional, Amital, Howard, additional, Andreoli, Laura, additional, Antonelli, Alessandro, additional, Arisi, Mariachiara, additional, Artusi, Carolina, additional, Atzeni, Fabiola, additional, Ballanti, Eleonora, additional, Barbati, Cristiana, additional, Barilaro, Giuseppe, additional, Bartoloni, Elena, additional, Ben-Ami, Dana, additional, Bettencourt, Andreia, additional, Bizzaro, Nicola, additional, Blank, Miri, additional, Bogdanos, Dimitrios P., additional, Boleixa, Daniela, additional, Borba, Vânia Vieira, additional, Borgiani, Paola, additional, Bragazzi, Nicola Luigi, additional, Brzosko, Iwona, additional, Brzosko, Marek, additional, Calzavara-Pinton, Piergiacomo, additional, Campi, Irene, additional, Cantarini, Luca, additional, Carranza-Muleiro, Rosa A., additional, Carvalho, Cláudia, additional, Caso, Francesco, additional, Ceccarelli, Fulvia, additional, Cervera, Ricard, additional, Chapman, Joab, additional, Chen, Xian, additional, Chimenti, Maria Sole, additional, Ciccacci, Cinzia, additional, Cipriano, Enrica, additional, Cohen Tervaert, Jan Willem, additional, Colasanti, Tania, additional, Conigliaro, Paola, additional, Conti, Fabrizio, additional, Coplan, Louis, additional, Costa, Luisa, additional, Croci, Stefania, additional, Cruz-Domínguez, María del Pilar, additional, Cutolo, Maurizio, additional, Dahan, Shani, additional, Damoiseaux, Jan, additional, De Carolis, Caterina, additional, Del Puente, Antonio, additional, Domingues, Vinicius, additional, Dreyfus, David H., additional, Drori, Tali, additional, Ehrenfeld, Michael, additional, Espinosa, Gerard, additional, Farina, Antonella, additional, Farina, Giuseppina Alessandra, additional, Ferraccioli, Gianfranco, additional, Finucci, Annacarla, additional, Fioravanti, Antonella, additional, Fischer, Katarzyna, additional, Fonti, Giulia Lavinia, additional, Francesca, Barone, additional, Franceschini, Franco, additional, Freire de Carvalho, Jozélio, additional, Fujio, Keishi, additional, García-Collinot, Grettel, additional, Generali, Elena, additional, Gerardi, Maria Chiara, additional, Gerli, Roberto, additional, Gertel, Smadar, additional, Giat, Eitan, additional, Greco, Elisabetta, additional, Gremese, Elisa, additional, Grunebaum, Eyal, additional, Gualtierotti, Roberta, additional, Guarino, Maria Domenica, additional, Guzner-Gur, Hanan, additional, He, Shu-Gui, additional, Iannuccelli, Cristina, additional, Jara, Luis J., additional, Jeandel, Pierre-Yves, additional, Kivity, Dr Shaye, additional, Kotyla, Przemyslaw J., additional, Krosser, Alec, additional, Latini, Andrea, additional, Leon-Ponte, Matilde, additional, Lerner, Aaron, additional, Levy, Roger Abramino, additional, Lichtbroun, Benjamin, additional, Lucchetti, Ramona, additional, Lu, Qianjin, additional, Margiotta, Domenico P.E., additional, Marinho, António, additional, Martínez-Bencomo, Michel A., additional, Matthias, Torsten, additional, Medina, Gabriela, additional, Meroni, Pier Luigi, additional, Lichtbroun, Michael, additional, Moreira Balbi, Gustavo Guimarães, additional, Muratore, Francesco, additional, Navarini, Luca, additional, Novelli, Giuseppe, additional, Pacucci, Viviana Antonella, additional, Peluso, Rosario, additional, Pendolino, Monica, additional, Pérez, Dolores, additional, Perricone, Carlo, additional, Perricone, Roberto, additional, Persani, Luca, additional, Petricca, Luca, additional, Pipitone, Nicolò, additional, Ramires de Jesús, Guilherme, additional, Resende, Gustavo, additional, Rizenbah, Chen, additional, Rodríguez-Pintó, Ignasi, additional, Rose, Noel R., additional, Rosenthal, Eric, additional, Rossi, Mariateresa, additional, Sakkas, Lazaros I., additional, Salvarani, Carlo, additional, Sarzi-Puttini, Piercarlo, additional, Scarpa, Raffaele, additional, Segal, Yahel, additional, Segel, Michael J., additional, Selmi, Carlo, additional, Seluk, Dr Lior, additional, Serena, Colafrancesco, additional, Sharabi, Amir, additional, Sharif, Kassem, additional, Shoenfeld, Netta, additional, Shoenfeld, Yehuda, additional, Signorelli, Flavio, additional, Silva, Ana Martins, additional, Silva, Berta Martins, additional, Slomovich, Sharon, additional, Somech, Raz, additional, Soriano, Alessandra, additional, Szekanecz, Zoltán, additional, Tanaka, Yoshiya, additional, Tenti, Sara, additional, Tincani, Angela, additional, Tolusso, Barbara, additional, Torres-Ruiz, Jiram, additional, Toubi, Elias, additional, Tozzoli, Renato, additional, Triggianese, Paola, additional, Trombetta, Amelia Chiara, additional, Tsokos, George C., additional, Tsuchida, Yumi, additional, Vadasz, Zahava, additional, Valesini, Guido, additional, van Beers, Joyce, additional, van Paassen, Pieter, additional, Vannucchi, Guia Maria, additional, Vasconcelos, Carlos, additional, Venturini, Marina, additional, Vera-Lastra, Olga, additional, Versini, Mathilde, additional, Vomero, Marta, additional, Watad, Abdulla, additional, Wu, Haijing, additional, and Zeng, Yong, additional

Published
2019
Full Text
View/download PDF

17. Systemic sclerosis sine scleroderma: clinical and serological features and relationship with other cutaneous subsets in a large series of patients from the national registry ‘SPRING’ of the Italian Society for Rheumatology

Author

De Angelis, Rossella, primary, Ferri, Clodoveo, additional, Giuggioli, Dilia, additional, Bajocchi, Gianluigi, additional, Dagna, Lorenzo, additional, Bellando-Randone, Silvia, additional, Zanframundo, Giovanni, additional, Foti, Rosario, additional, Cacciapaglia, Fabio, additional, Cuomo, Giovanna, additional, Ariani, Alarico, additional, Rosato, Edoardo, additional, Lepri, Gemma, additional, Girelli, Francesco, additional, Riccieri, Valeria, additional, Zanatta, Elisabetta, additional, Bosello, Silvia Laura, additional, Cavazzana, Ilaria, additional, Ingegnoli, Francesca, additional, De Santis, Maria, additional, Murdaca, Giuseppe, additional, Abignano, Giuseppina, additional, Romeo, Nicoletta, additional, Della Rossa, Alessandra, additional, Caminiti, Maurizio, additional, Iuliano, Anna Maria, additional, Ciano, Giovanni, additional, Beretta, Lorenzo, additional, Bagnato, Gianluca, additional, Lubrano, Ennio, additional, De Andres, Ilenia, additional, Giollo, Alessandro, additional, Saracco, Marta, additional, Agnes, Cecilia, additional, Cipolletta, Edoardo, additional, Lumetti, Federica, additional, Spinella, Amelia, additional, Magnani, Luca, additional, Campochiaro, Corrado, additional, De Luca, Giacomo, additional, Codullo, Veronica, additional, Visalli, Elisa, additional, Di Vico, Claudio, additional, Gigante, Antonietta, additional, Pellagrino, Greta, additional, Pigatto, Erika, additional, Lazzaroni, Maria-Grazia, additional, Franceschini, Franco, additional, Generali, Elena, additional, Mennillo, Gianna, additional, Barsotti, Simone, additional, Mariano, Giuseppa Pagano, additional, Furini, Federica, additional, Vultaggio, Licia, additional, Parisi, Simone, additional, Peroni, Clara Lisa, additional, Rozza, Davide, additional, Zanetti, Anna, additional, Carrara, Greta, additional, Landolfi, Gianpiero, additional, Scirè, Carlo Alberto, additional, Bianchi, Gerolamo, additional, Fusaro, Enrico, additional, Sebastiani, Gian Domenico, additional, Govoni, Marcello, additional, D'Angelo, Salvatore, additional, Cozzi, Franco, additional, Guiducci, Serena, additional, Doria, Andrea, additional, Salvarani, Carlo, additional, Iannone, Florenzo, additional, and Matucci-Cerinic, Marco, additional

Published
2023
Full Text
View/download PDF

19. Negative prognostic impact of electrolyte disorders in patients hospitalized for Covid-19 in a large multicenter study

Author

Genovesi, S, Regolisti, G, Rebora, P, Occhino, G, Belli, M, Molon, G, Citerio, G, Beltrame, A, Maloberti, A, Generali, E, Giannattasio, C, Epis, O, Rossetti, C, Bellelli, G, De Nalda, A, Capua, I, Valsecchi, M, Genovesi, Simonetta, Regolisti, Giuseppe, Rebora, Paola, Occhino, Giuseppe, Belli, Michele, Molon, Giulio, Citerio, Giuseppe, Beltrame, Anna, Maloberti, Alessandro, Generali, Elena, Giannattasio, Cristina, Epis, Oscar Massimiliano, Rossetti, Claudio, Bellelli, Giuseppe, De Nalda, Ana Lleo, Capua, Ilaria, Valsecchi, Maria Grazia, Genovesi, S, Regolisti, G, Rebora, P, Occhino, G, Belli, M, Molon, G, Citerio, G, Beltrame, A, Maloberti, A, Generali, E, Giannattasio, C, Epis, O, Rossetti, C, Bellelli, G, De Nalda, A, Capua, I, Valsecchi, M, Genovesi, Simonetta, Regolisti, Giuseppe, Rebora, Paola, Occhino, Giuseppe, Belli, Michele, Molon, Giulio, Citerio, Giuseppe, Beltrame, Anna, Maloberti, Alessandro, Generali, Elena, Giannattasio, Cristina, Epis, Oscar Massimiliano, Rossetti, Claudio, Bellelli, Giuseppe, De Nalda, Ana Lleo, Capua, Ilaria, and Valsecchi, Maria Grazia

Abstract

Background: The prognostic impact of electrolyte disorders in hospitalized COVID-19 patients is unclear. Methods: The study included all adult patients hospitalized for COVID-19 in four hospitals in Northern Italy between January 2020 and May 2021 with at least one serum potassium and sodium measurement performed within 3 days since admission. Primary outcome was in-hospital death; secondary outcome was Intensive Care Unit (ICU) admission. A cause-specific Cox proportional-hazards regression model was used for investigating the association between potassium and sodium (as either categorical or continuous variables) and mortality or admission to ICU. Results: Analyses included 3,418 adult hospitalized COVID-19 patients. At multivariable analysis, both hyperkalemia (Hazard Ratio, [HR] 1.833, 95% Confidence Interval [CI] 1.371–2.450) and sK above the median (K 5.1 vs 4.1 mmol/L: HR 1.523, 95% CI 1.295–1.798), and hypernatremia (HR 2.313, 95%CI 1.772–3.018) and sNa above the median (Na 149 vs 139 mmol/L: HR 1.442, 95% CI 1.234–1.686), were associated with in-hospital death, whereas hypokalemia and hyponatremia were not. Hyponatremia was associated with increased hazard of ICU admission (HR 1.884, 95%CI 1.389–2.556). Conclusions: Electrolyte disorders detected at hospital admission may allow early identification of COVID-19 patients at increased risk of adverse outcomes.

Published
2023

20. Practice pattern for the use of intravenous iloprost for the treatment of peripheral vasculopathy in systemic sclerosis: A case–control study from the Italian national multicenter “SPRING” (Systemic Sclerosis Progression InvestiGation) Registry

Author

Riccieri, Valeria, Pellegrino, Greta, Cipolletta, Edoardo, Giuggioli, Dilia, Bajocchi, Gianluigi, Bellando-Randone, Silvia, Dagna, Lorenzo, Zanframundo, Giovanni, Foti, Rosario, Cacciapaglia, Fabio, Cuomo, Giovanna, Ariani, Alarico, Rosato, Edoardo, Lepri, Gemma, Girelli, Francesco, Zanatta, Elisabetta, Bosello, Silvia Laura, Cavazzana, Ilaria, Ingegnoli, Francesca, De Santis, Maria, Murdaca, Giuseppe, Abignano, Giuseppina, Romeo, Nicoletta, Della Rossa, Alessandra, Caminiti, Maurizio, Iuliano, Annamaria, Ciano, Giovanni, Beretta, Lorenzo, Bagnato, Gianluca, Lubrano, Ennio, De Andres, Ilenia, Giollo, Alessandro, Saracco, Marta, Agnes, Cecilia, Lumetti, Federica, Spinella, Amelia, Magnani, Luca, Campochiaro, Corrado, De Luca, Giacomo, Codullo, Veronica, Visalli, Elisa, Di Vico, Claudio, Gigante, Antonietta, Saccon, Francesca, Grazia Lazzaroni, Maria, Franceschini, Franco, Generali, Elena, Mennillo, Gianna, Barsotti, Simone, Pagano Mariano, Giuseppa, Calabrese, Francesca, Furini, Federica, Vultaggio, Licia, Parisi, Simone, Peroni, Clara Lisa, Bianchi, Gerolamo, Conti, Fabrizio, Cozzi, Franco, D’Angelo, Salvatore, Doria, Andrea, Fusaro, Enrico, Govoni, Marcello, Guiducci, Serena, Iannone, Florenzo, Salvarani, Carlo, Sebastiani, Gian Domenico, Ferri, Clodoveo, Matucci-Cerinic, Marco, and De Angelis, Rossella

Abstract

Background: Intravenous iloprost has been widely used for the treatment of systemic sclerosis peripheral vasculopathy. No agreement has been found on the regimen and the dosage of intravenous iloprost in different scleroderma subset conditions. This study aimed to evaluate the modalities of intravenous iloprost administration within a large cohort of systemic sclerosis patients from the SPRING Registry and to identify any associated clinical-demographic, instrumental or therapeutic data.Patients and Methods: Data of systemic sclerosis patients treated with intravenous iloprost for at least 1 year (case group) were retrospectively analyzed, including different timing and duration of intravenous iloprost session, and compared with those of untreated patients (control group).Results: Out of 1895 analyzed patients, 937 (49%) received intravenous iloprost treatment, while 958 (51%) were assigned to the control group. Among cases, about 70% were treated every 4 weeks, 24% with an interval of more than 4 weeks, and only 6% of less than 4 weeks. Most patients receiving the treatment every 4 weeks, or less, underwent infusion cycle for 1 day only, while if it was scheduled with an interval of more than 4 weeks, a total number of 5 consecutive days of infusions was the preferred regimen. The comparison between the two groups revealed that patients treated with intravenous iloprost had a higher frequency of DUs (p < 0.001), pitting scars (p < 0.001), diffuse cutaneous involvement (p < 0.001), interstitial lung disease (p < 0.002), as well as higher rates of anti-topoisomerase I, “late” scleroderma patternat nailfold videocapillaroscopy. These findings were confirmed by multivariate analysis.Conclusion: Our data provide a picture on the Italian use of intravenous iloprost among systemic sclerosis patients and showed that it was usually employed in patients with a more aggressive spectrum of the disease. The disparity of intravenous iloprost treatment strategies in the different centers suggests the need of a rational therapeutical approach based on the clinical characteristics of different patients’ subsets.

Published
2024
Full Text
View/download PDF

26. Negative prognostic impact of electrolyte disorders in patients hospitalized for Covid-19 in a large multicenter study

Author

Genovesi, Simonetta, primary, Regolisti, Giuseppe, additional, Rebora, Paola, additional, Occhino, Giuseppe, additional, Belli, Michele, additional, Molon, Giulio, additional, Citerio, Giuseppe, additional, Beltrame, Anna, additional, Maloberti, Alessandro, additional, Generali, Elena, additional, Giannattasio, Cristina, additional, Epis, Oscar Massimiliano, additional, Rossetti, Claudio, additional, Bellelli, Giuseppe, additional, De Nalda, Ana Lleo, additional, Capua, Ilaria, additional, and Valsecchi, Maria Grazia, additional

Published
2022
Full Text
View/download PDF

27. Prevalence and Death Rate of COVID-19 in Autoimmune Systemic Diseases in the First Three Pandemic Waves. Relationship with Disease Subgroups and Ongoing Therapies

Author

Ferri, Clodoveo, primary, Antonelli, Alessandro, primary, Raimondo, Vincenzo, additional, Gragnani, Laura, additional, Giuggioli, Dilia, additional, Dagna, Lorenzo, additional, Tavoni, Antonio, additional, Ursini, Francesco, additional, L'Andolina, Massimo, additional, Caso, Francesco, additional, Ruscitti, Piero, additional, Caminiti, Maurizio, additional, Foti, Rosario, additional, Riccieri, Valeria, additional, Guiducci, Serena, additional, Pellegrini, Roberta, additional, Zanatta, Elisabetta, additional, Varcasia, Giuseppe, additional, Olivo, Domenico, additional, Gigliotti, Pietro, additional, Cuomo, Giovanna, additional, Murdaca, Giuseppe, additional, Cecchetti, Riccardo, additional, De Angelis, Rossella, additional, Romeo, Nicoletta, additional, Ingegnoli, Francesca, additional, Cozzi, Franco, additional, Codullo, Veronica, additional, Cavazzana, Ilaria, additional, Colaci, Michele, additional, Abignano, Giuseppina, additional, De Santis, Maria, additional, Lubrano, Ennio, additional, Fusaro, Enrico, additional, Spinella, Amelia, additional, Lumetti, Federica, additional, De Luca, Giacomo, additional, Bellando-Randone, Silvia, additional, Visalli, Elisa, additional, Bosco, Ylenia Dal, additional, Amato, Giorgio, additional, Giannini, Daiana, additional, Bilia, Silvia, additional, Masini, Francesco, additional, Pellegrino, Greta, additional, Pigatto, Erika, additional, Generali, Elena, additional, Mariano, Giuseppa Pagano, additional, Pettiti, Giorgio, additional, Zanframundo, Giovanni, additional, Brittelli, Raffaele, additional, Aiello, Vincenzo, additional, Caminiti, Rodolfo, additional, Scorpiniti, Daniela, additional, Ferrari, Tommaso, additional, Campochiaro, Corrado, additional, Brusi, Veronica, additional, Fredi, Micaela, additional, Moschetti, Liala, additional, Cacciapaglia, Fabio, additional, Paparo, Sabrina Rosaria, additional, Ragusa, Francesca, additional, Mazzi, Valeria, additional, Elia, Giusy, additional, Ferrari, Silvia Martina, additional, Di Cola, Ilenia, additional, Vadacca, Marta, additional, Lorusso, Sebastiano, additional, Monti, Monica, additional, Lorini, Serena, additional, Aprile, Maria Letizia, additional, Tasso, Marco, additional, Miccoli, Mario, additional, Bosello, Silvia, additional, D'Angelo, Salvatore, additional, Doria, Andrea, additional, Franceschini, Franco, additional, Meliconi, Riccardo, additional, Matucci-Cerinic, Marco, additional, Iannone, Florenzo, additional, Giacomelli, Roberto, additional, Salvarani, Carlo, additional, Zignego, Anna Linda, additional, and Fallahi, Poupak, additional

Published
2022
Full Text
View/download PDF

28. Prevalence and Death Rate of COVID-19 in Autoimmune Systemic Diseases in the First Three Pandemic Waves. Relationship with Disease Subgroups and Ongoing Therapies

Author

Ferri, Clodoveo, Raimondo, Vincenzo, Gragnani, Laura, Giuggioli, Dilia, Dagna, Lorenzo, Tavoni, Antonio, Ursini, Francesco, L'Andolina, Massimo, Caso, Francesco, Ruscitti, Piero, Caminiti, Maurizio, Foti, Rosario, Riccieri, Valeria, Guiducci, Serena, Pellegrini, Roberta, Zanatta, Elisabetta, Varcasia, Giuseppe, Olivo, Domenico, Gigliotti, Pietro, Cuomo, Giovanna, Murdaca, Giuseppe, Cecchetti, Riccardo, De Angelis, Rossella, Romeo, Nicoletta, Ingegnoli, Francesca, Cozzi, Franco, Codullo, Veronica, Cavazzana, Ilaria, Colaci, Michele, Abignano, Giuseppina, De Santis, Maria, Lubrano, Ennio, Fusaro, Enrico, Spinella, Amelia, Lumetti, Federica, De Luca, Giacomo, Bellando-Randone, Silvia, Visalli, Elisa, Bosco, Ylenia Dal, Amato, Giorgio, Giannini, Daiana, Bilia, Silvia, Masini, Francesco, Pellegrino, Greta, Pigatto, Erika, Generali, Elena, Mariano, Giuseppa Pagano, Pettiti, Giorgio, Zanframundo, Giovanni, Brittelli, Raffaele, Aiello, Vincenzo, Caminiti, Rodolfo, Scorpiniti, Daniela, Ferrari, Tommaso, Campochiaro, Corrado, Brusi, Veronica, Fredi, Micaela, Moschetti, Liala, Cacciapaglia, Fabio, Paparo, Sabrina Rosaria, Ragusa, Francesca, Mazzi, Valeria, Elia, Giusy, Ferrari, Silvia Martina, Di Cola, Ilenia, Vadacca, Marta, Lorusso, Sebastiano, Monti, Monica, Lorini, Serena, Aprile, Maria Letizia, Tasso, Marco, Miccoli, Mario, Bosello, Silvia Laura, D'Angelo, Salvatore, Doria, Andrea, Franceschini, Franco, Meliconi, Riccardo, Matucci-Cerinic, Marco, Iannone, Florenzo, Giacomelli, Roberto, Salvarani, Carlo, Zignego, Anna Linda, Fallahi, Poupak, Antonelli, Alessandro, Bosello, Silvia (ORCID:0000-0002-4837-447X), Ferri, Clodoveo, Raimondo, Vincenzo, Gragnani, Laura, Giuggioli, Dilia, Dagna, Lorenzo, Tavoni, Antonio, Ursini, Francesco, L'Andolina, Massimo, Caso, Francesco, Ruscitti, Piero, Caminiti, Maurizio, Foti, Rosario, Riccieri, Valeria, Guiducci, Serena, Pellegrini, Roberta, Zanatta, Elisabetta, Varcasia, Giuseppe, Olivo, Domenico, Gigliotti, Pietro, Cuomo, Giovanna, Murdaca, Giuseppe, Cecchetti, Riccardo, De Angelis, Rossella, Romeo, Nicoletta, Ingegnoli, Francesca, Cozzi, Franco, Codullo, Veronica, Cavazzana, Ilaria, Colaci, Michele, Abignano, Giuseppina, De Santis, Maria, Lubrano, Ennio, Fusaro, Enrico, Spinella, Amelia, Lumetti, Federica, De Luca, Giacomo, Bellando-Randone, Silvia, Visalli, Elisa, Bosco, Ylenia Dal, Amato, Giorgio, Giannini, Daiana, Bilia, Silvia, Masini, Francesco, Pellegrino, Greta, Pigatto, Erika, Generali, Elena, Mariano, Giuseppa Pagano, Pettiti, Giorgio, Zanframundo, Giovanni, Brittelli, Raffaele, Aiello, Vincenzo, Caminiti, Rodolfo, Scorpiniti, Daniela, Ferrari, Tommaso, Campochiaro, Corrado, Brusi, Veronica, Fredi, Micaela, Moschetti, Liala, Cacciapaglia, Fabio, Paparo, Sabrina Rosaria, Ragusa, Francesca, Mazzi, Valeria, Elia, Giusy, Ferrari, Silvia Martina, Di Cola, Ilenia, Vadacca, Marta, Lorusso, Sebastiano, Monti, Monica, Lorini, Serena, Aprile, Maria Letizia, Tasso, Marco, Miccoli, Mario, Bosello, Silvia Laura, D'Angelo, Salvatore, Doria, Andrea, Franceschini, Franco, Meliconi, Riccardo, Matucci-Cerinic, Marco, Iannone, Florenzo, Giacomelli, Roberto, Salvarani, Carlo, Zignego, Anna Linda, Fallahi, Poupak, Antonelli, Alessandro, and Bosello, Silvia (ORCID:0000-0002-4837-447X)

Abstract

Objective: Autoimmune systemic diseases (ASD) represent a predisposing condition to COVID-19. Our prospective, observational multicenter telephone survey study aimed to investigate the prevalence, prognostic factors, and outcomes of COVID-19 in Italian ASD patients. Methods: The study included 3,918 ASD pts (815 M, 3103 F; mean age 59 +/- 12SD years) consecutively recruited between March 2020 and May 2021 at the 36 referral centers of COVID-19 and ASD Italian Study Group. The possible development of COVID-19 was recorded by means of a telephone survey using a standardized symptom assessment questionnaire. Results: ASD patients showed a significantly higher prevalence of COVID-19 (8.37% vs. 6.49%; p<0.0001) but a death rate statistically comparable to the Italian general population (3.65% vs. 2.95%). Among the 328 ASD patients developing COVID-19, 17% needed hospitalization, while mild-moderate manifestations were observed in 83% of cases. Moreover, 12/57 hospitalized patients died due to severe interstitial pneumonia and/or cardiovascular events; systemic sclerosis (SSc) patients showed a significantly higher COVID-19-related death rate compared to the general population (6.29% vs. 2.95%; p=0.018). Major adverse prognostic factors to develop COVID-19 were: older age, male gender, SSc, pre-existing ASD-related interstitial lung involvement, and long-term steroid treatment. Of note, patients treated with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) showed a significantly lower prevalence of COVID-19 compared to those without (3.58% vs. 46.99%; p=0.000), as well as the SSc patients treated with low dose aspirin (with 5.57% vs. without 27.84%; p=0.000). Conclusion: During the first three pandemic waves, ASD patients showed a death rate comparable to the general population despite the significantly higher prevalence of COVID-19. A significantly increased COVID-19-related mortality was recorded in only SSc patients' subgroup, possibly favored

Published
2022

29. Sex-related Differences in Systemic Sclerosis: A Multicenter Cross-sectional Study From the National Registry of the Italian Society for Rheumatology

Author

De Angelis, Rossella, Giuggioli, Dilia, Bajocchi, Gianluigi, Dagna, Lorenzo, Zanframundo, Giovanni, Foti, Rosario, Cacciapaglia, Fabio, Cuomo, Giovanna, Ariani, Alarico, Rosato, Edoardo, Guiducci, Serena, Girelli, Francesco, Riccieri, Valeria, Zanatta, Elisabetta, Bosello, Silvia Laura, Cavazzana, Ilaria, Ingegnoli, Francesca, Santis, Maria De, Murdaca, Giuseppe, Abignano, Giuseppina, Romeo, Nicoletta, Della Rossa, Alessandra, Caminiti, Maurizio, Iuliano, Annamaria, Ciano, Giovanni, Beretta, Lorenzo, Bagnato, Gianluca, Lubrano, Ennio, De Andres, Ilenia, Giollo, Alessandro, Saracco, Marta, Agnes, Cecilia, Lumetti, Federica, Spinella, Amelia, Magnani, Luca, Campochiaro, Corrado, De Luca, Giacomo, Codullo, Veronica, Visalli, Elisa, Masini, Francesco, Gigante, Antonietta, Bellando-Randone, Silvia, Pellegrino, Greta, Pigatto, Erika, Dall'Ara, Francesca, Lazzaroni, Maria Grazia, Generali, Elena, Mennillo, Gianna, Barsotti, Simone, Mariano, Giuseppa Pagano, Calabrese, Francesca, Furini, Federica, Vultaggio, Licia, Parisi, Simone, Peroni, Clara Lisa, Risa, Anna Maria, Rozza, Davide, Zanetti, Anna, Carrara, Greta, Landolfi, Giampiero, Scirè, Carlo Alberto, Bianchi, Gerolamo, Fusaro, Enrico, Sebastiani, Gian Domenico, Govoni, Marcello, D'Angelo, Salvatore, Cozzi, Franco, Doria, Andrea, Iannone, Florenzo, Salvarani, Carlo, Matucci-Cerinic, Marco, Ferri, Clodoveo, Bosello, Silvia (ORCID:0000-0002-4837-447X), De Angelis, Rossella, Giuggioli, Dilia, Bajocchi, Gianluigi, Dagna, Lorenzo, Zanframundo, Giovanni, Foti, Rosario, Cacciapaglia, Fabio, Cuomo, Giovanna, Ariani, Alarico, Rosato, Edoardo, Guiducci, Serena, Girelli, Francesco, Riccieri, Valeria, Zanatta, Elisabetta, Bosello, Silvia Laura, Cavazzana, Ilaria, Ingegnoli, Francesca, Santis, Maria De, Murdaca, Giuseppe, Abignano, Giuseppina, Romeo, Nicoletta, Della Rossa, Alessandra, Caminiti, Maurizio, Iuliano, Annamaria, Ciano, Giovanni, Beretta, Lorenzo, Bagnato, Gianluca, Lubrano, Ennio, De Andres, Ilenia, Giollo, Alessandro, Saracco, Marta, Agnes, Cecilia, Lumetti, Federica, Spinella, Amelia, Magnani, Luca, Campochiaro, Corrado, De Luca, Giacomo, Codullo, Veronica, Visalli, Elisa, Masini, Francesco, Gigante, Antonietta, Bellando-Randone, Silvia, Pellegrino, Greta, Pigatto, Erika, Dall'Ara, Francesca, Lazzaroni, Maria Grazia, Generali, Elena, Mennillo, Gianna, Barsotti, Simone, Mariano, Giuseppa Pagano, Calabrese, Francesca, Furini, Federica, Vultaggio, Licia, Parisi, Simone, Peroni, Clara Lisa, Risa, Anna Maria, Rozza, Davide, Zanetti, Anna, Carrara, Greta, Landolfi, Giampiero, Scirè, Carlo Alberto, Bianchi, Gerolamo, Fusaro, Enrico, Sebastiani, Gian Domenico, Govoni, Marcello, D'Angelo, Salvatore, Cozzi, Franco, Doria, Andrea, Iannone, Florenzo, Salvarani, Carlo, Matucci-Cerinic, Marco, Ferri, Clodoveo, and Bosello, Silvia (ORCID:0000-0002-4837-447X)

Abstract

Objective. There is still a great deal to learn about the influence of sex in systemic sclerosis (SSc). In this respect, national registries provide large and homogeneous patient cohorts for analytical studies. We therefore investigated a wide-ranging and well-characterized SSc series with the aim of identifying sex differences in disease expression, with a special focus on demographic, clinical, and serological characteristics.Methods. A multicenter SSc cohort of 2281 patients, including 247 men, was recruited in the Italian Systemic sclerosis PRogression INvestiGation (SPRING) registry. Demographic data, disease manifestations, serological profile, and internal organ involvement were compared.Results. The overall female/male ratio was 8.2:1. Female/male ratios for limited cutaneous SSc, diffuse cutaneous SSc, and SSc sine scleroderma subsets were 8.7:1, 4.9:1, and 10.7:1, respectively. A shorter time from onset of Raynaud phenomenon to SSc diagnosis, an increased prevalence of the diffuse cutaneous subset, renal crisis, and digital ulcers were found in males, whereas a significantly higher percentage of sicca syndrome, serum antinuclear antibodies, antiextractable nuclear antigens, anti-La/SSB, and anticentromere protein B was detected in the female group. Males exhibited lower left ventricular ejection fraction, as well as higher prevalence of conduction blocks, arrhythmias, ground glass, and honeycombing. Moreover, forced vital capacity and total lung capacity were medially lower in men than in women. Finally, males were more frequently treated with immunosuppressive drugs.Conclusion. Our study further supports the presence of several sex-related differences in patients with SSc. These differences were pronounced in the severity of cutaneous, peripheral vascular, and cardiopulmonary involvement for male patients, whereas an increased prevalence of sicca syndrome and a specific autoantibody profile characterized the female sex.

Published
2022

34. Systemic sclerosis Progression INvestiGation (SPRING) Italian registry: demographic and clinico-serological features of scleroderma spectrum

Author

Ferri, Clodoveo, Giuggioli, Dilia, Guiducci, Serena, Lumetti, Federica, Bajocchi, Gianluigi, Magnani, Luca, Codullo, Veronica, Ariani, Alarico, Girelli, Francesco, Riccieri, Valeria, Pellegrino, Greta, Bosello, Silvia, Foti, Rosario, Visalli, Elisa, Amato, Giorgio, Benenati, Alessia, Cuomo, Giovanna, Iannone, Florenzo, Cacciapaglia, Fabio, Angelis, Rossella, Ingegnoli, Francesca, ROSSELLA TALOTTA, Campochiaro, Corrado, Dagna, Lorenzo, Luca, Giacomo, Bellando-Randone, Silvia, Spinella, Amelia, Murdaca, Giuseppe, Romeo, Nicoletta, Santis, Maria, Generali, Elena, Barsotti, Simone, Della Rossa, Alessandra, Cavazzana, Ilaria, Dall Ara, Francesca, Lazzaroni, Maria G., Cozzi, Franco, Andrea Doria, Pigatto, Erika, ELISABETTA ZANATTA, Ciano, Giovanni, Beretta, Lorenzo, Abignano, Giuseppina, D Angelo, Salvatore, Mennillo, Gianna, Bagnato, Gianluca, Calabrese, Francesca, Caminiti, Maurizio, Pagano Mariano, Giuseppa, Battaglia, Elisabetta, Lubrano, Ennio, Zanframundo, Giovanni, Iuliano, Annamaria, Furini, Federica, Zanetti, Anna, Carrara, Greta, Rumi, Federica, Scirè, Carlo Alberto, Matucci-Cerinic, Marco, Ferri, C, Giuggioli, D, Guiducci, S, Lumetti, F, Bajocchi, G, Magnani, L, Codullo, V, Ariani, A, Girelli, F, Riccieri, V, Pellegrino, G, Bosello, S, Foti, R, Visalli, E, Amato, G, Benenati, A, Cuomo, G, Iannone, F, Cacciapaglia, F, De Angelis, R, Ingegnoli, F, Talotta, R, Campochiaro, C, Dagna, L, De Luca, G, Bellando-Randone, S, Spinella, A, Murdaca, G, Romeo, N, De Santis, M, Generali, E, Barsotti, S, Della Rossa, A, Cavazzana, I, Dall'Ara, F, Lazzaroni, M, Cozzi, F, Doria, A, Pigatto, E, Zanatta, E, Ciano, G, Beretta, L, Abignano, G, D'Angelo, S, Mennillo, G, Bagnato, G, Calabrese, F, Caminiti, M, Pagano Mariano, G, Battaglia, E, Lubrano, E, Zanframundo, G, Iuliano, A, Furini, F, Zanetti, A, Carrara, G, Rumi, F, Scirè, C, Matucci-Cerinic, M, Ferri, Clodoveo, Giuggioli, Dilia, Guiducci, Serena, Lumetti, Federica, Bajocchi, Gianluigi, Magnani, Luca, Codullo, Veronica, Ariani, Alarico, Girelli, Francesco, Riccieri, Valeria, Pellegrino, Greta, Bosello, Silvia, Foti, Rosario, Visalli, Elisa, Amato, Giorgio, Benenati, Alessia, Cuomo, Giovanna, Iannone, Florenzo, Cacciapaglia, Fabio, De Angelis, Rossella, Ingegnoli, Francesca, Talotta, Rossella, Campochiaro, Corrado, Dagna, Lorenzo, De Luca, Giacomo, Bellando-Randone, Silvia, Spinella, Amelia, Murdaca, Giuseppe, Romeo, Nicoletta, De Santis, Maria, Generali, Elena, Barsotti, Simone, Della Rossa, Alessandra, Cavazzana, Ilaria, Dall'Ara, Francesca, Lazzaroni, Maria G, Cozzi, Franco, Doria, Andrea, Pigatto, Erika, Zanatta, Elisabetta, Ciano, Giovanni, Beretta, Lorenzo, Abignano, Giuseppina, D'Angelo, Salvatore, Mennillo, Gianna, Bagnato, Gianluca, Calabrese, Francesca, Caminiti, Maurizio, Pagano Mariano, Giuseppa, Battaglia, Elisabetta, Lubrano, Ennio, Zanframundo, Giovanni, Iuliano, Annamaria, Furini, Federica, Zanetti, Anna, Carrara, Greta, Rumi, Federica, Scirè, Carlo Alberto, and Matucci-Cerinic, Marco

Subjects
Male, Scleroderma, Systemic, Settore MED/16 - REUMATOLOGIA, systemic sclerosis, Raynaud’s phenomenon, VEDOSS, Raynaud Disease, Microscopic Angioscopy, Cohort Studies, Systemic sclerosi, Italy, Humans, Registries, Systemic sclerosis
Abstract

Objectives: Systemic sclerosis (SSc) is a severe multiple-organ disease characterised by unpredictable clinical course, inadequate response to treatment, and poor prognosis. National SSc registries may provide large and representative patients cohorts required for descriptive and prognostic studies. Therefore, the Italian Society for Rheumatology promoted the registry SPRING (Systemic sclerosis Progression INvestiGation). Methods: The SPRING is a multi-centre rheumatological cohort study encompassing the wide scleroderma spectrum, namely the primary Raynaud's phenomenon (pRP), suspected secondary RP, Very Early Diagnosis of Systemic Sclerosis (VEDOSS), and definite SSc. Here we describe the demographic and clinical characteristics of a population of 2,028 Italian patients at the initial phase of enrolment, mainly focusing on the cohort of 1,538 patients with definite SSc. Results: Definite SSc showed a significantly higher prevalence of digital ulcers, capillaroscopic 'late' pattern, oesophageal and cardio-pulmonary involvement compared to VEDOSS, as expected on the basis of the followed classification criteria. The in-depth analysis of definite SSc revealed that male gender, diffuse cutaneous subset, and anti-Scl70 seropositivity were significantly associated with increased prevalence of the most harmful disease manifestations. Similarly, patients with very short RP duration (≤1 year) at SSc diagnosis showed a statistically increased prevalence of unfavourable clinico-serological features. Conclusions: Nationwide registries with suitable subsetting of patients and follow-up studies since the prodromal phase of the disease may give us valuable insights into the SSc natural history and main prognostic factors.

Published
2020

35. Covid-19 And Rheumatic Autoimmune Systemic Diseases: Role of Pre-Existing Lung Involvement and Ongoing Treatments

Author

Ferri, Clodoveo, primary, Giuggioli, Dilia, additional, Raimondo, Vincenzo, additional, L’Andolina, Massimo, additional, Dagna, Lorenzo, additional, Tavoni, Antonio, additional, Caso, Francesco, additional, Ursini, Francesco, additional, Ruscitti, Piero, additional, Caminiti, Maurizio, additional, Foti, Rosario, additional, Riccieri, Valeria, additional, Guiducci, Serena, additional, Pellegrini, Roberta, additional, Zanatta, Elisabetta, additional, Varcasia, Giuseppe, additional, Olivo, Domenico, additional, Gigliotti, Pietro, additional, Cuomo, Giovanna, additional, Murdaca, Giuseppe, additional, Cecchetti, Riccardo, additional, De Angelis, Rossella, additional, Romeo, Nicoletta, additional, Ingegnoli, Francesca, additional, Cozzi, Franco, additional, Codullo, Veronica, additional, Cavazzana, Ilaria, additional, Colaci, Michele, additional, Abignano, Giuseppina, additional, De Santis, Maria, additional, Lubrano, Ennio, additional, Fusaro, Enrico, additional, Rossa, Alessandra Della, additional, Spinella, Amelia, additional, Lumetti, Federica, additional, De Luca, Giacomo, additional, Bellando-Randone, Silvia, additional, Visalli, Elisa, additional, Dal Bosco, Ylenia, additional, Amato, Giorgio, additional, Giannini, Daiana, additional, Bilia, Silvia, additional, Masini, Francesco, additional, Pellegrino, Greta, additional, Pigatto, Erika, additional, Generali, Elena, additional, Mariano, Giuseppa Pagano, additional, Pettiti, Giorgio, additional, Zanframundo, Giovanni, additional, Brittelli, Raffaele, additional, Aiello, Vincenzo, additional, Caminiti, Rodolfo, additional, Scorpiniti, Daniela, additional, Ferrari, Tommaso, additional, Campochiaro, Corrado, additional, Brusi, Veronica, additional, Fredi, Micaela, additional, Moschetti, Liala, additional, Cacciapaglia, Fabio, additional, Gragnani, Laura, additional, Monti, Monica, additional, Lorini, Serena, additional, Paparo, Sabrina Rosaria, additional, Ragusa, Francesca, additional, Mazzi, Valeria, additional, Elia, Giusy, additional, Ferrari, Silvia Martina, additional, Di Cola, Ilenia, additional, Vadacca, Marta, additional, Lorusso, Sebastiano, additional, Barsotti, Simone, additional, Aprile, Maria Letizia, additional, Marco, Tasso, additional, Miccoli, Mario, additional, Bosello, Silvia, additional, Matucci-Cerinic, Marco, additional, D'Angelo, Salvatore, additional, Doria, Andrea, additional, Franceschini, Franco, additional, Meliconi, Riccardo, additional, Iannone, Florenzo, additional, Giacomelli, Roberto, additional, Zignego, Anna Linda, additional, Fallahi, Poupak, additional, and Antonelli, Alessandro, additional

Published
2021
Full Text
View/download PDF

37. COVID-19 and systemic sclerosis: clinicopathological implications from Italian nationwide survey study

Author

Ferri, Clodoveo, Giuggioli, Dilia, Raimondo, Vincenzo, Dagna, Lorenzo, Riccieri, Valeria, Zanatta, Elisabetta, Guiducci, Serena, Tavoni, Antonio, Foti, Rosario, Cuomo, Giovanna, De Angelis, Rossella, Cozzi, Franco, Murdaca, Giuseppe, Cavazzana, Ilaria, Romeo, Nicoletta, Codullo, Veronica, Ingegnoli, Francesca, Pellegrini, Roberta, Varcasia, Giuseppe, Della Rossa, Alessandra, De Santis, Maria, Abignano, Giuseppina, Colaci, Michele, Caminiti, Maurizio, L'Andolina, Massimo, Lubrano, Ennio, Spinella, Amelia, Lumetti, Federica, De Luca, Giacomo, Bellando-Randone, Silvia, Visalli, Elisa, Bilia, Silvia, Giannini, Daiana, Masini, Francesco, Pellegrino, Greta, Pigatto, Erika, Generali, Elena, Dall'Ara, Francesca, Pagano Mariano, Giuseppa, Barsotti, Simone, Pettiti, Giorgio, Zanframundo, Giovanni, Brittelli, Raffaele, Aiello, Vincenzo, Scorpiniti, Daniela, Ferrari, Tommaso, Caminiti, Rodolfo, Campochiaro, Corrado, Cecchetti, Riccardo, Gigliotti, Pietro, Olivo, Domenico, Ursini, Francesco, Brusi, Veronica, Meliconi, Riccardo, Scarpa, Raffaele, Fusaro, Enrico, Zignego, Anna Linda, D'Angelo, Salvatore, Iannone, Florenzo, Matucci-Cerinic, Marco, Doria, Andrea, Miccoli, Mario, Paparo, Sabrina Rosaria, Ragusa, Francesca, Elia, Giusy, Ferrari, Silvia Martina, Fallahi, Poupak, Antonelli, Alessandro, Rossa, Alessandra Della, and Mariano, Giuseppa Pagano

Published
2021
Full Text
View/download PDF

38. Covid-19 And Rheumatic Autoimmune Systemic Diseases: Role of Pre-Existing Lung Involvement and Ongoing Treatments

Author

Ferri, Clodoveo, Giuggioli, Dilia, Raimondo, Vincenzo, L'Andolina, Massimo, Dagna, Lorenzo, Tavoni, Antonio, Caso, Francesco, Ursini, Francesco, Ruscitti, Piero, Caminiti, Maurizio, Foti, Rosario, Riccieri, Valeria, Guiducci, Serena, Pellegrini, Roberta, Zanatta, Elisabetta, Varcasia, Giuseppe, Olivo, Domenico, Gigliotti, Pietro, Cuomo, Giovanna, Murdaca, Giuseppe, Cecchetti, Riccardo, De Angelis, Rossella, Romeo, Nicoletta, Ingegnoli, Francesca, Cozzi, Franco, Codullo, Veronica, Cavazzana, Ilaria, Colaci, Michele, Abignano, Giuseppina, De Santis, Maria, Lubrano, Ennio, Fusaro, Enrico, Rossa, Alessandra Della, Spinella, Amelia, Lumetti, Federica, De Luca, Giacomo, Bellando-Randone, Silvia, Visalli, Elisa, Dal Bosco, Ylenia, Amato, Giorgio, Giannini, Daiana, Bilia, Silvia, Masini, Francesco, Pellegrino, Greta, Pigatto, Erika, Generali, Elena, Mariano, Giuseppa Pagano, Pettiti, Giorgio, Zanframundo, Giovanni, Brittelli, Raffaele, Aiello, Vincenzo, Caminiti, Rodolfo, Scorpiniti, Daniela, Ferrari, Tommaso, Campochiaro, Corrado, Brusi, Veronica, Fredi, Micaela, Moschetti, Liala, Cacciapaglia, Fabio, Gragnani, Laura, Monti, Monica, Lorini, Serena, Paparo, Sabrina Rosaria, Ragusa, Francesca, Mazzi, Valeria, Elia, Giusy, Ferrari, Silvia Martina, Di Cola, Ilenia, Vadacca, Marta, Lorusso, Sebastiano, Barsotti, Simone, Aprile, Maria Letizia, Marco, Tasso, Miccoli, Mario, Bosello, Silvia Laura, Matucci-Cerinic, Marco, D'Angelo, Salvatore, Doria, Andrea, Franceschini, Franco, Meliconi, Riccardo, Iannone, Florenzo, Giacomelli, Roberto, Zignego, Anna Linda, Fallahi, Poupak, Antonelli, Alessandro, Bosello, Silvia (ORCID:0000-0002-4837-447X), Ferri, Clodoveo, Giuggioli, Dilia, Raimondo, Vincenzo, L'Andolina, Massimo, Dagna, Lorenzo, Tavoni, Antonio, Caso, Francesco, Ursini, Francesco, Ruscitti, Piero, Caminiti, Maurizio, Foti, Rosario, Riccieri, Valeria, Guiducci, Serena, Pellegrini, Roberta, Zanatta, Elisabetta, Varcasia, Giuseppe, Olivo, Domenico, Gigliotti, Pietro, Cuomo, Giovanna, Murdaca, Giuseppe, Cecchetti, Riccardo, De Angelis, Rossella, Romeo, Nicoletta, Ingegnoli, Francesca, Cozzi, Franco, Codullo, Veronica, Cavazzana, Ilaria, Colaci, Michele, Abignano, Giuseppina, De Santis, Maria, Lubrano, Ennio, Fusaro, Enrico, Rossa, Alessandra Della, Spinella, Amelia, Lumetti, Federica, De Luca, Giacomo, Bellando-Randone, Silvia, Visalli, Elisa, Dal Bosco, Ylenia, Amato, Giorgio, Giannini, Daiana, Bilia, Silvia, Masini, Francesco, Pellegrino, Greta, Pigatto, Erika, Generali, Elena, Mariano, Giuseppa Pagano, Pettiti, Giorgio, Zanframundo, Giovanni, Brittelli, Raffaele, Aiello, Vincenzo, Caminiti, Rodolfo, Scorpiniti, Daniela, Ferrari, Tommaso, Campochiaro, Corrado, Brusi, Veronica, Fredi, Micaela, Moschetti, Liala, Cacciapaglia, Fabio, Gragnani, Laura, Monti, Monica, Lorini, Serena, Paparo, Sabrina Rosaria, Ragusa, Francesca, Mazzi, Valeria, Elia, Giusy, Ferrari, Silvia Martina, Di Cola, Ilenia, Vadacca, Marta, Lorusso, Sebastiano, Barsotti, Simone, Aprile, Maria Letizia, Marco, Tasso, Miccoli, Mario, Bosello, Silvia Laura, Matucci-Cerinic, Marco, D'Angelo, Salvatore, Doria, Andrea, Franceschini, Franco, Meliconi, Riccardo, Iannone, Florenzo, Giacomelli, Roberto, Zignego, Anna Linda, Fallahi, Poupak, Antonelli, Alessandro, and Bosello, Silvia (ORCID:0000-0002-4837-447X)

Abstract

Background: The Covid-19 pandemic may have a deleterious impact on patients with autoimmune systemic diseases (ASD) due to their deep immune-system alterations. Objective: This study aims to investigate the prevalence of symptomatic Covid-19 and its correlations with both organ involvement and ongoing treatments in a large series of Italian ASD patients during the first wave of pandemic. Methods: Our multicenter telephone 6-week survey included 3,029 unselected ASD patients enrolled at 36 tertiary referral centers of northern, central, and southern Italian macro-areas with different diffusion of the pandemic. Symptomatic SARS-CoV-2 infection was classified as definite Covid-19 (presence of symptoms plus positive oral/nasopharyngeal swabs) or highly suspected Covid-19 (highly suggestive symptoms, in the absence of a swab testing). Results: A significantly higher prevalence of definite plus highly suspected Covid-19 compared to the Italian general population was detected in the whole ASD series (p=.000), as well as in patients from the three macro-areas (p=.000 in all). Statistically higher prevalence of Covid-19 was also found in connective tissue diseases compared to chronic arthritis subgroup (p=.000) and in ASD patients with pre-existing interstitial lung involvement (p=.000). Patients treated with either conventional disease-modifying anti-rheumatic drugs (DMARDs) and/or biological DMARDs showed a significantly lower prevalence of Covid-19 (p=.000 in both). Finally, scleroderma patients undergoing low-dose aspirin showed a significantly lower rate of Covid-19 compared to those without (p=0.003). Conclusion: The higher prevalence of Covid-19 in ASD patients, along with the significant correlations with important clinical features and therapeutic regimens, suggests the need to develop targeted prevention/management strategies during the current pandemic wave.

Published
2021

39. Long-term Outcome of Children Born to Women with Autoimmune Rheumatic Diseases: A Multicentre, Nationwide Study on 299 Randomly Selected Individuals

Author

Andreoli, Laura, primary, Nalli, Cecilia, additional, Lazzaroni, Maria Grazia, additional, Carini, Chiara, additional, Dall’Ara, Francesca, additional, Reggia, Rossella, additional, Rodrigues, Marília, additional, Benigno, Carolina, additional, Baldissera, Elena, additional, Bartoloni, Elena, additional, Basta, Fabio, additional, Bellisai, Francesca, additional, Bortoluzzi, Alessandra, additional, Campochiaro, Corrado, additional, Cantatore, Francesco Paolo, additional, Caporali, Roberto, additional, Ceribelli, Angela, additional, Chighizola, Cecilia B., additional, Conigliaro, Paola, additional, Corrado, Addolorata, additional, Cutolo, Maurizio, additional, D’Angelo, Salvatore, additional, De Stefani, Elena, additional, Doria, Andrea, additional, Favaro, Maria, additional, Fischetti, Colomba, additional, Foti, Rosario, additional, Gabrielli, Armando, additional, Generali, Elena, additional, Gerli, Roberto, additional, Gerosa, Maria, additional, Larosa, Maddalena, additional, Maier, Armin, additional, Malavolta, Nazzarena, additional, Meroni, Marianna, additional, Meroni, Pier Luigi, additional, Montecucco, Carlomaurizio, additional, Mosca, Marta, additional, Padovan, Melissa, additional, Paolazzi, Giuseppe, additional, Pazzola, Giulia, additional, Peccatori, Susanna, additional, Perricone, Roberto, additional, Pettiti, Giorgio, additional, Picerno, Valentina, additional, Prevete, Immacolata, additional, Ramoni, Véronique, additional, Romeo, Nicoletta, additional, Ruffatti, Amelia, additional, Salvarani, Carlo, additional, Sebastiani, Gian Domenico, additional, Selmi, Carlo, additional, Serale, Francesca, additional, Sinigaglia, Luigi, additional, Tani, Chiara, additional, Trevisani, Marica, additional, Vadacca, Marta, additional, Valentini, Eleonora, additional, Valesini, Guido, additional, Visalli, Elisa, additional, Vivaldelli, Ester, additional, Zuliani, Lucia, additional, and Tincani, Angela, additional

Published
2021
Full Text
View/download PDF

40. Rheumatoid factor and anti-citrullinated peptide antibodies in the general population: hepatitis B and C virus association and 15-year-risk of rheumatoid arthritis

Author

Generali, Elena, primary, De Santis, Maria, additional, Isailovic, Natasa, additional, Palermo, Bianca, additional, Guidelli, Giacomo Maria, additional, Ceribelli, Angela, additional, Alborghetti, Fausto, additional, Colloredo, Guido, additional, Porrati, Luisa, additional, Matthias, Torsten, additional, Zucchi, Alberto, additional, and Selmi, Carlo, additional

Published
2021
Full Text
View/download PDF

42. Anti-phospholipid antibody prevalence and association with subclinical atherosclerosis and atherothrombosis in the general population

Author

Selmi, Carlo, primary, De Santis, Maria, additional, Battezzati, Pier Maria, additional, Generali, Elena, additional, Lari, Simone Aldo, additional, Ceribelli, Angela, additional, Isailovic, Natasa, additional, Zermiani, Paola, additional, Neidhöfer, Sandra, additional, Matthias, Torsten, additional, Scirè, Carlo A., additional, Baldassarre, Damiano, additional, and Zuin, Massimo, additional

Published
2020
Full Text
View/download PDF

47. SAT0267 SERUM ANTI-HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN ANTIBODY CHARACTERIZES SYSTEMIC SCLEROSIS WITH ANTI CENTROMERE ANTIBODY AND SEVERE RAYNAUD’S PHENOMENON WITH DIGITAL ULCERS

Author

Isailovic, Natasa, primary, Ceribelli, Angela, additional, Gorlino, Carolina, additional, Generali, Elena, additional, Santis, Maria De, additional, Caprioli, Marta, additional, Guidelli, Giacomo Maria, additional, Sarzi-Puttini, Piercarlo, additional, Satoh, Minoru, additional, and Selmi, Carlo, additional

Published
2019
Full Text
View/download PDF

48. AB0446 REAL-LIFE USE OF BARICITINIB IN RHEUMATOID ARTHRITIS: A MULTICENTER OBSERVATIONAL STUDY OF 150 PATIENTS

Author

Guidelli, Giacomo Maria, primary, Generali, Elena, additional, Bazzani, Chiara, additional, Gorla, Roberto, additional, Sakellariou, Garifallia, additional, Limonta, Massimiliano, additional, Chimenti, Maria Sole, additional, Perricone, Roberto, additional, Conticini, Edoardo, additional, Frediani, Bruno, additional, Boffini, Nicola, additional, Dagna, Lorenzo, additional, Riva, Marta, additional, Pozzi, Maria Rosa, additional, Grembiale, Rosa Daniela, additional, Serban, Teodora, additional, Bianchi, Gerolamo, additional, and Selmi, Carlo, additional

Published
2019
Full Text
View/download PDF

49. Comparison of the risks of hospitalisation for cardiovascular events in patients with rheumatoid arthritis treated with tocilizumab and etanercept

Author

Generali, E, Carrara, G, Selmi, C, Verstappen, S, Zambon, A, Bortoluzzi, A, Silvagni, E, Scirè, C, Generali, Elena, Carrara, Greta, Selmi, Carlo, Verstappen, Suzanne M M, Zambon, Antonella, Bortoluzzi, Alessandra, Silvagni, Ettore, Scirè, Carlo Alberto, Generali, E, Carrara, G, Selmi, C, Verstappen, S, Zambon, A, Bortoluzzi, A, Silvagni, E, Scirè, C, Generali, Elena, Carrara, Greta, Selmi, Carlo, Verstappen, Suzanne M M, Zambon, Antonella, Bortoluzzi, Alessandra, Silvagni, Ettore, and Scirè, Carlo Alberto

Abstract

Objective. To verify if tocilizumab (TCZ) is associated with an increased risk of cardiovascular (CV) events compared with etanercept (ETN) in rheumatoid arthritis (RA). Methods. This is a retrospective cohort study on administrative healthcare databases (AHD) in Italy. Patients were identified using a validated algorithm based on AHD. Exposure to specific drugs was estimated by the drug prescription recorded in the AHD. The occurrence of acute CV events (myocardial infarction, stroke, other CV events) was derived from the hospital discharge forms. The association between TCZ or ETN and CV events was estimated using competing risk models, adjusting for pre-specified confounders. Results. We identified 1,752 subjects with RA, 1,086 treated with ETN and 666 with TCZ. TCZ did not increase the overall risk of acute CV events, even when adjusted for pre-specified confounders (hazard ratio HR 0.95, 95% confidence interval 95%CI 0.54-1.66), specifically of acute myocardial infarction (HR 0.39, 95%CI 0.15-1.06), stroke (HR 1.44, 95%CI 0.24-8.68) or other CV event (1.07, 95%CI 0.59-1.92). Conclusion. RA patients with TCZ do not have a medium-term excess of CV risk in patients compared with ETN.

Published
2018

50. High mortality in COVID‐19 patients with mild respiratory disease.

Author

Masetti, Chiara, Generali, Elena, Colapietro, Francesca, Voza, Antonio, Cecconi, Maurizio, Messina, Antonio, Omodei, Paolo, Angelini, Claudio, Ciccarelli, Michele, Badalamenti, Salvatore, Canonica, G. Walter, Lleo, Ana, and Aghemo, Alessio

Subjects
*COVID-19, *RESPIRATORY diseases, *PULMONARY fibrosis, *HOSPITAL mortality, *SYMPTOMS
Abstract

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has infected 189 000 people in Italy, with more than 25 000 deaths. Several predictive factors of mortality have been identified; however, none has been validated in patients presenting with mild disease. Methods: Patients with a diagnosis of interstitial pneumonia caused by SARS‐CoV‐2, presenting with mild symptoms, and requiring hospitalization in a non‐intensive care unit with known discharge status were prospectively collected and retrospectively analysed. Demographical, clinical and biochemical parameters were recorded, as need for non‐invasive mechanical ventilation and admission in intensive care unit. Univariate and multivariate logistic regression analyses were used to identify independent predictors of death. Results: Between 28 February and 10 April 2020, 229 consecutive patients were included in the study cohort; the majority were males with a mean age of 60 years. 54% of patients had at least one comorbidity, with hypertension being the most commonly represented, followed by diabetes mellitus. 196 patients were discharged after a mean of 9 days, while 14.4% died during hospitalization because of respiratory failure. Age higher than 75 years, low platelet count (<150 × 103/mm3) and higher ferritin levels (>750 ng/mL) were independent predictors of death. Comorbidities were not independently associated with in‐hospital mortality. Conclusions: In‐hospital mortality of patients with COVID‐19 presenting with mild symptoms is high and is associated with older age, platelet count and ferritin levels. Identifying early predictors of outcome can be useful in the clinical practice to better stratify and manage patients with COVID‐19. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results