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Objective: To evaluate the potential side effects and efficacy also to find the risk factors that contributed to the side effects of both vaccines in Indonesia. Methods: This is a prospective cross-sectional study was conducted in October-December 2021; informations collection was carried out by using a standardized questionnaire and disseminated through social media. All full-dosed AstraZeneca and Moderna vaccine participants above 18 y old were included. Results: Among 406 participants, 73.4% were female, 87.2% were in the group of 18-30 y, 80 % were Java race, and 52.6% of them had asthma. In this study, the number of participants between AstraZeneca and Moderna was almost the same (50.5% and 49.5%). The most common side effects experienced after first of AstraZeneca and Moderna vaccine were fever (65.8% and 45.3%) respectively, sore arm (77.5% and 63.6%) respectively, headache (52.7% and 40.8%) respectively, and drowsiness (64.4% and 53.7%) respectively. After the second dose were fever (26.8% and 55.2) respectively, nausea (4.8% and 18%) respectively, diarrhea (0.5% and 5%) respectively, headache (27.3 and 44.8%) respectively and allergic reaction or skin rash (1% and 6%) respectively. After the first and second dose, participants with the AstraZeneca vaccine were most likely to get infected by COVID-19 (6.3% and 4.3%), respectively. Conclusion: Both AstraZeneca and Moderna vaccines' most common side effects were mild-moderate such as fever, sore arm, headache, drowsiness, and nausea. Several risk factors contributed to the side effects, such as younger age (median: 22), and female participants, and non-overweight BMI (median: 21.8).