Search

Your search keyword '"Geller, Daniel A"' showing total 896 results
Start Over Author "Geller, Daniel A"
896 results on '"Geller, Daniel A"'

5. Is Persistent Motor or Vocal Tic Disorder a Milder Form of Tourette Syndrome?

Author

Claudio‐Campos, Karla, Stevens, Daniel, Koo, Sang‐Wahn, Valko, Alexa, Bienvenu, Oscar Joseph, Budman, Cathy B, Cath, Danielle C, Darrow, Sabrina, Geller, Daniel, Goes, Fernando S, Grados, Marco A, Greenberg, Benjamin D, Greenberg, Erica, Hirschtritt, Matthew E, Illmann, Cornelia, Ivankovic, Franjo, King, Robert A, Knowles, James A, Krasnow, Janice, Lee, Paul C, Lyon, Gholson J, McCracken, James T, Robertson, Mary M, Osiecki, Lisa, Riddle, Mark A, Rouleau, Guy, Sandor, Paul, Nestadt, Gerald, Samuels, Jack, Scharf, Jeremiah M, Mathews, Carol A, and Study, for the Tourette Association of America International Consortium for Genetics and the OCD Collaborative Genetics Association

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Brain Disorders, Behavioral and Social Science, Anxiety Disorders, Tourette Syndrome, Neurodegenerative, Serious Mental Illness, Mental Health, 2.1 Biological and endogenous factors, Aetiology, Mental health, Attention Deficit Disorder with Hyperactivity, Comorbidity, Humans, Obsessive-Compulsive Disorder, Tic Disorders, Tics, chronic tics, meta&#8208, analysis, severity, Tourette, Tourette Association of America International Consortium for Genetics (TAAICG) and the OCD Collaborative Genetics Association Study, meta-analysis, Human Movement and Sports Sciences, Neurology & Neurosurgery, Clinical sciences
Abstract

BackgroundPersistent motor or vocal tic disorder (PMVT) has been hypothesized to be a forme fruste of Tourette syndrome (TS). Although the primary diagnostic criterion for PMVT (presence of motor or vocal tics, but not both) is clear, less is known about its clinical presentation.ObjectiveThe goals of this study were to compare the prevalence and number of comorbid psychiatric disorders, tic severity, age at tic onset, and family history for TS and PMVT.MethodsWe analyzed data from two independent cohorts using generalized linear equations and confirmed our findings using meta-analyses, incorporating data from previously published literature.ResultsRates of obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD) were lower in PMVT than in TS in all analyses. Other psychiatric comorbidities occurred with similar frequencies in PMVT and TS in both cohorts, although meta-analyses suggested lower rates of most psychiatric disorders in PMVT compared with TS. ADHD and OCD increased the odds of comorbid mood, anxiety, substance use, and disruptive behaviors, and accounted for observed differences between PMVT and TS. Age of tic onset was approximately 2 years later, and tic severity was lower in PMVT than in TS. First-degree relatives had elevated rates of TS, PMVT, OCD, and ADHD compared with population prevalences, with rates of TS equal to or greater than PMVT rates.ConclusionsOur findings support the hypothesis that PMVT and TS occur along a clinical spectrum in which TS is a more severe and PMVT a less severe manifestation of a continuous neurodevelopmental tic spectrum disorder. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Published
2021

6. User-Driven Functional Movement Training with a Wearable Hand Robot after Stroke

Author

Park, Sangwoo, Fraser, Michaela, Weber, Lynne M., Meeker, Cassie, Bishop, Lauri, Geller, Daniel, Stein, Joel, and Ciocarlie, Matei

Subjects
Computer Science - Robotics
Abstract

We studied the performance of a robotic orthosis designed to assist the paretic hand after stroke. It is wearable and fully user-controlled, serving two possible roles: as a therapeutic tool that facilitates device mediated hand exercises to recover neuromuscular function or as an assistive device for use in everyday activities to aid functional use of the hand. We present the clinical outcomes of a pilot study designed as a feasibility test for these hypotheses. 11 chronic stroke (> 2 years) patients with moderate muscle tone (Modified Ashworth Scale less than or equal to 2 in upper extremity) engaged in a month-long training protocol using the orthosis. Individuals were evaluated using standardized outcome measures, both with and without orthosis assistance. Fugl-Meyer post intervention scores without robotic assistance showed improvement focused specifically at the distal joints of the upper limb, suggesting the use of the orthosis as a rehabilitative device for the hand. Action Research Arm Test scores post intervention with robotic assistance showed that the device may serve an assistive role in grasping tasks. These results highlight the potential for wearable and user-driven robotic hand orthoses to extend the use and training of the affected upper limb after stroke., Comment: 10 pages, 15 figures, Camera ready version

Published
2019
Full Text
View/download PDF

9. Contributors

Author

Abdi, Yakoub Aw Aden, primary, Ahuja, Samridhi, additional, Barlaan, Devin R., additional, Branquinho, Mariana, additional, Buck, Tara R., additional, Burn, Michele, additional, Burton, E. Thomaseo, additional, Candelari, Abigail E., additional, Chakraborty, Sampurna, additional, Cromer, Lisa D., additional, Daud, Abdifatah Haji, additional, Davis, Joanne L., additional, Dzierzewski, Joseph M., additional, Erps, Kristen H., additional, Escher, J.C., additional, Ferezghi, Mahdi Razmara, additional, Fernández-Artamendi, Sergio, additional, Fitzpatrick, Madison, additional, Fonseca, Ana, additional, Fruchter, Yvette, additional, Gardini, Danielle H., additional, Geller, Daniel A., additional, Gemmill, Alan W., additional, Ghosh, Debasruti, additional, González-Roz, Alba, additional, Gorrell, Sasha, additional, Guzick, Andrew G., additional, Halder, Susmita, additional, Hamiel, Daniel, additional, Haugland, Bente Storm Mowatt, additional, Hirshler, Yafit, additional, Højgaard, Davíð R.M.A., additional, Huryk, Kathryn M., additional, Husabø, Elisabeth Bakke, additional, Hybel, Katja Anna, additional, Ishikawa, Shin-ichi, additional, Ivarsson, Tord, additional, Jacofsky, Matthew, additional, Jaff, Dilshad, additional, Jellinek, Emily R., additional, Jensen, Sanne, additional, Johnson, Amanda R., additional, Johnson, Madelyn, additional, Jomeen, Julie, additional, Jones, Catriona, additional, Kamody, Rebecca C., additional, Khan, Anowra, additional, Lah, Suncica, additional, Landry, Lindsey N., additional, Le Grange, Daniel, additional, Liu, Tai Wa, additional, Mahapatra, Ananya, additional, Mahato, Akash Kumar, additional, Mahmood, Zahid, additional, Malik, Tamkeen Ashraf, additional, Marshall, Claire, additional, Martin, Colin R., additional, Martínez-Borba, Verónica, additional, Martínez-Loredo, Víctor, additional, Miers, Anne C., additional, Milgrom, Jeannette, additional, Mittal, Shalini, additional, Muscatello, Virginia Sklar, additional, Neziroglu, Fugen, additional, Ng, Shamay S.M., additional, Pasipanodya, Thomas Enias, additional, Patel, Vinood B., additional, Perez, Elliottnell, additional, Pozza, Andrea, additional, Preedy, Victor R., additional, Pruiksma, Kristi, additional, Raj, Saurabh, additional, Rajendram, Rajkumar, additional, Ravyts, Scott G., additional, Rodrigues, Andre L., additional, Sardabi, Maryam Saeidi, additional, Schneider, Sophie C., additional, Secades-Villa, Roberto, additional, Seidi, Pegah AM, additional, Selvapandiyan, Jaiganesh, additional, Shaked, Omer, additional, Sharma, Pragya, additional, Sicouri, Gemma, additional, Singh, Tushar, additional, Skarphedinsson, Gudmundur, additional, Soto, Pablo, additional, Srivastava, Paakhi, additional, Stapersma, L., additional, Stewart, Elizabeth, additional, Storch, Eric A., additional, Subramaniam, Ponnusamy, additional, Tanaka, Katsutoshi, additional, Tanaka, Mika, additional, Tavallaei, Arezoo Moradi, additional, Tay, Kok-Wai, additional, Thomsen, Per Hove, additional, Tien, Ingrid S., additional, Urizar, Jr., Guido G., additional, Utens, E.M.W.J., additional, Van der Giessen, Daniëlle, additional, van Steensel, Francisca J.A., additional, Warner, Carrie Masia, additional, Wergeland, Gro Janne, additional, Wolpe, Samara, additional, and Wood, Jeffrey J., additional

Published
2023
Full Text
View/download PDF

11. Neuropsychopharmacotherapy in Children and Adolescents

Author

Walitza, Susanne, Berger, Gregor, Geller, Daniel, Smigielski, Lukasz, Riederer, Peter, Section editor, Nagatsu, Toshiharu, Section editor, Riederer, Peter, editor, Laux, Gerd, editor, Nagatsu, Toshiharu, editor, Le, Weidong, editor, and Riederer, Christian, editor

Published
2022
Full Text
View/download PDF

13. Immune-Related Comorbidities in Childhood-Onset Obsessive Compulsive Disorder: Lifetime Prevalence in the Obsessive Compulsive Disorder Collaborative Genetics Association Study

Author

Westwell-Roper, Clara, Williams, Kyle A, Samuels, Jack, Bienvenu, O Joseph, Cullen, Bernadette, Goes, Fernando S, Grados, Marco A, Geller, Daniel, Greenberg, Benjamin D, Knowles, James A, Krasnow, Janice, McLaughlin, Nicole C, Nestadt, Paul, Shugart, Yin-Yao, Nestadt, Gerald, and Stewart, S Evelyn

Subjects
Biomedical and Clinical Sciences, Immunology, Arthritis, Infectious Diseases, Brain Disorders, Pediatric, Clinical Research, Autoimmune Disease, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Good Health and Well Being, Adult, Autoimmune Diseases, Child, Comorbidity, Female, Humans, Male, Obsessive-Compulsive Disorder, Prevalence, Prospective Studies, Psychiatric Status Rating Scales, Surveys and Questionnaires, autoimmune diseases, childhood-onset, communicable diseases, comorbidity, immune system diseases, inflammation, obsessive compulsive disorder, Pharmacology and Pharmaceutical Sciences, Developmental & Child Psychology, Pharmacology and pharmaceutical sciences
Abstract

Objective: To evaluate the lifetime prevalence of infectious, inflammatory, and autoimmune disorders in a multisite study of probands with childhood-onset obsessive compulsive disorder (OCD) and their first-degree relatives. Methods: Medical questionnaires were completed by 1401 probands and 1045 first-degree relatives in the OCD Collaborative Genetics Association Study. Lifetime prevalence of immune-related diseases was compared with the highest available population estimate and reported as a point estimate with 95% adjusted Wald interval. Worst-episode OCD severity and symptom dimensions were assessed with the Yale-Brown Obsessive Compulsive Scale (YBOCS) and Symptom Checklist (YBOCS-CL). Results: Probands reported higher-than-expected prevalence of scarlet fever (4.0 [3.1-5.2]% vs. 1.0%-2.0%, z = 1.491, p

Published
2019

17. Exome sequencing in obsessive–compulsive disorder reveals a burden of rare damaging coding variants

Author

Halvorsen, Mathew, Samuels, Jack, Wang, Ying, Greenberg, Benjamin D., Fyer, Abby J., McCracken, James T., Geller, Daniel A., Knowles, James A., Zoghbi, Anthony W., Pottinger, Tess D., Grados, Marco A., Riddle, Mark A., Bienvenu, O. Joseph, Nestadt, Paul S., Krasnow, Janice, Goes, Fernando S., Maher, Brion, Nestadt, Gerald, and Goldstein, David B.

Published
2021
Full Text
View/download PDF

19. Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD)

Author

Ritter, McKenzie L, Guo, Wei, Samuels, Jack F, Wang, Ying, Nestadt, Paul S, Krasnow, Janice, Greenberg, Benjamin D, Fyer, Abby J, McCracken, James T, Geller, Daniel A, Murphy, Dennis L, Knowles, James A, Grados, Marco A, Riddle, Mark A, Rasmussen, Steven A, McLaughlin, Nicole C, Nurmi, Erika L, Askland, Kathleen D, Cullen, Bernadette, Piacentini, John, Pauls, David L, Bienvenu, Joseph, Stewart, Evelyn, Goes, Fernando S, Maher, Brion, Pulver, Ann E, Mattheisen, Manuel, Qian, Ji, Nestadt, Gerald, and Shugart, Yin Yao

Subjects
Biological Sciences, Genetics, Attention Deficit Hyperactivity Disorder (ADHD), Behavioral and Social Science, Mental Health, Serious Mental Illness, Human Genome, Anxiety Disorders, Pediatric, Brain Disorders, Aetiology, 2.1 Biological and endogenous factors, Mental health, ADHD, OCD, GWAS, meta-analysis, polygenic score, protein-protein link analysis, eQTL, Clinical Sciences, Neurosciences, Biochemistry and cell biology, Biological psychology
Abstract

Objective: The aim of this study was to identify any potential genetic overlap between attention deficit hyperactivity disorder (ADHD) and obsessive compulsive disorder (OCD). We hypothesized that since these disorders share a sub-phenotype, they may share common risk alleles. In this manuscript, we report the overlap found between these two disorders. Methods: A meta-analysis was conducted between ADHD and OCD, and polygenic risk scores (PRS) were calculated for both disorders. In addition, a protein-protein analysis was completed in order to examine the interactions between proteins; p-values for the protein-protein interaction analysis was calculated using permutation. Conclusion: None of the single nucleotide polymorphisms (SNPs) reached genome wide significance and there was little evidence of genetic overlap between ADHD and OCD.

Published
2017

20. Systematic Review and Meta-Analysis: An Empirical Approach to Defining Treatment Response and Remission in Pediatric Obsessive-Compulsive Disorder

Author

Farhat, Luis C., Vattimo, Edoardo F.Q., Ramakrishnan, Divya, Levine, Jessica L.S., Johnson, Jessica A., Artukoglu, Bekir B., Landeros-Weisenberger, Angeli, Asbahr, Fernando R., Cepeda, Sandra L., Comer, Jonathan S., Fatori, Daniel, Franklin, Martin E., Freeman, Jennifer B., Geller, Daniel A., Grant, Paul J., Goodman, Wayne K., Heyman, Isobel, Ivarsson, Tord, Lenhard, Fabian, Lewin, Adam B., Li, Fenghua, Merlo, Lisa J., Mohsenabadi, Hamid, Peris, Tara S., Piacentini, John, Rosa-Alcázar, Ana I., Rosa-Alcázar, Àngel, Rozenman, Michelle, Sapyta, Jeffrey J., Serlachius, Eva, Shabani, Mohammad J., Shavitt, Roseli G., Small, Brent J., Skarphedinsson, Gudmundur, Swedo, Susan E., Thomsen, Per Hove, Turner, Cynthia, Weidle, Bernhard, Miguel, Euripedes C., Storch, Eric A., Mataix-Cols, David, and Bloch, Michael H.

Published
2021
Full Text
View/download PDF

22. Efficacy and acceptability of cognitive‐behavioral therapy and serotonin reuptake inhibitors for pediatric obsessive‐compulsive disorder: a network meta‐analysis.

Author

Cervin, Matti, McGuire, Joseph F., D'Souza, Johann M., De Nadai, Alessandro S., Aspvall, Kristina, Goodman, Wayne K., Andrén, Per, Schneider, Sophie C., Geller, Daniel A., Mataix‐Cols, David, and Storch, Eric A.

Subjects
PATIENT compliance, MEDICAL care, SEROTONIN uptake inhibitors, TERMINATION of treatment, INTERNET, TREATMENT effectiveness, META-analysis, TELEPSYCHIATRY, TELEPSYCHOLOGY, OBSESSIVE-compulsive disorder, SYSTEMATIC reviews, MEDLINE, COGNITIVE therapy, ONLINE information services, PSYCHOLOGY information storage & retrieval systems, CHILDREN
Abstract

Background: Cognitive‐behavioral therapy (CBT) and serotonin reuptake inhibitors (SRIs) are recommended treatments for pediatric obsessive‐compulsive disorder (OCD), but their relative efficacy and acceptability have not been comprehensively examined. Further, it remains unclear whether the efficacy of in‐person CBT is conserved when delivered in other formats, such as over telephone/webcam or as Internet‐delivered CBT (ICBT). Methods: PubMed, PsycINFO, trial registries, and previous systematic reviews were searched for randomized controlled trials (RCTs) comparing CBT (in‐person, webcam/telephone‐delivered, or ICBT) or SRIs with control conditions or each other. Network meta‐analyses were conducted to examine efficacy (post‐treatment Children's Yale‐Brown Obsessive Compulsive Scale) and acceptability (treatment discontinuation). Confidence in effect estimates was evaluated with CINeMA (Confidence in Network Meta‐Analysis). Results: Thirty eligible RCTs and 35 contrasts comprising 2,057 youth with OCD were identified. In‐person CBT was significantly more efficacious than ICBT, waitlist, relaxation training, and pill placebo (MD range: 3.95–11.10; CINeMA estimate of confidence: moderate) but did not differ significantly from CBT delivered via webcam/telephone (MD: 0.85 [−2.51, 4.21]; moderate), SRIs (MD: 3.07 [−0.07, 6.20]; low), or the combination of in‐person CBT and SRIs (MD: −1.20 [−5.29, 2.91]; low). SRIs were significantly more efficacious than pill placebo (MD: 4.59 [2.70, 6.48]; low) and waitlist (MD: 8.03 [4.24, 11.82]; moderate). No significant differences for acceptability emerged, but confidence in estimates was low. Conclusions: In‐person CBT and SRIs produce clear benefits compared to waitlist and pill placebo and should be integral parts of the clinical management of pediatric OCD, with in‐person CBT overall having a stronger evidence base. The combination of in‐person CBT and SRIs may be most efficacious, but few studies hinder firm conclusions. The efficacy of CBT appears conserved when delivered via webcam/telephone, while more trials evaluating ICBT are needed. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

25. The Centrality of Doubting and Checking in the Network Structure of Obsessive-Compulsive Symptom Dimensions in Youth

Author

Cervin, Matti, Perrin, Sean, Olsson, Elin, Aspvall, Kristina, Geller, Daniel A., Wilhelm, Sabine, McGuire, Joseph, Lázaro, Luisa, Martínez-González, Agustin E., Barcaccia, Barbara, Pozza, Andrea, Goodman, Wayne K., Murphy, Tanya K., Seçer, İsmail, Piqueras, José A., Rodríguez-Jiménez, Tiscar, Godoy, Antonio, Rosa-Alcázar, Ana I., Rosa-Alcázar, Ángel, Ruiz-García, Beatriz M., Storch, Eric A., and Mataix-Cols, David

Published
2020
Full Text
View/download PDF

29. Joseph Biederman, MD (1947-2023)

Author

Ceranoglu, Atilla, primary, Doyle, Robert, additional, Faraone, Stephen V., additional, Geller, Daniel, additional, Joshi, Gagan, additional, Rubin, David, additional, Spencer, Thomas, additional, Surman, Craig, additional, Uchida, Mai, additional, Wilens, Timothy, additional, and Wozniak, Janet, additional

Published
2023
Full Text
View/download PDF

30. Changes in Dosing and Dose Timing of D-Cycloserine Explain Its Apparent Declining Efficacy for Augmenting Exposure Therapy for Anxiety-related Disorders: An Individual Participant-data Meta-analysis

Author

Rosenfield, David, Smits, Jasper A.J., Hofmann, Stefan G., Mataix-Cols, David, de la Cruz, Lorena Fernández, Andersson, Erik, Rück, Christian, Monzani, Benedetta, Pérez-Vigil, Ana, Frumento, Paolo, Davis, Michael, de Kleine, Rianne A., Difede, JoAnn, Dunlop, Boadie W., Farrell, Lara J., Geller, Daniel, Gerardi, Maryrose, Guastella, Adam J., Hendriks, Gert-Jan, Kushner, Matt G., Lee, Francis S., Lenze, Eric J., Levinson, Cheri A., McConnell, Harry, Plag, Jens, Pollack, Mark H., Ressler, Kerry J., Rodebaugh, Thomas L., Rothbaum, Barbara O., Storch, Eric A., Ströhle, Andreas, Tart, Candyce D., Tolin, David F., van Minnen, Agnes, Waters, Allison M., Weems, Carl F., Wilhelm, Sabine, Wyka, Katarzyna, Altemus, Margaret, Anderson, Page, Cukor, Judith, Finck, Claudia, Geffken, Gary R., Golfels, Fabian, Goodman, Wayne K., Gutner, Cassidy A., Heyman, Isobel, Jovanovic, Tanja, Lewin, Adam B., McNamara, Joseph P., Murphy, Tanya K., Norrholm, Seth, Thuras, Paul, Turner, Cynthia, and Otto, Michael W.

Published
2019
Full Text
View/download PDF

31. Contemporary models of pediatric obsessive–compulsive disorder: An evaluation with a large clinical sample

Author

De Nadai, Alessandro, Nagpal, Prianka S, Piacentini, John, Peris, Tara S, Geffken, Gary R, Geller, Daniel A, Murphy, Tanya K, Storch, Eric A, and Lewin, Adam B

Subjects
Psychology, Clinical and Health Psychology, Applied and Developmental Psychology, Pediatric, Mental Health, Brain Disorders, Mental health, Adolescent, Child, Child, Preschool, Factor Analysis, Statistical, Female, Humans, Male, Models, Psychological, Obsessive Behavior, Obsessive-Compulsive Disorder, Pediatrics, Obsessive-compulsive disorder, Assessment, Obsessive–compulsive disorder, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Clinical and health psychology
Abstract

We evaluated the construct validity of the Child Yale-Brofwn Obsessive-Compulsive Scale (CYBOCS) in a large clinical sample (N=730) using confirmatory factor analysis. Results found inadequate fit for a priori models, though a model accounting for overlapping item content displayed good fit. Parallel obsessions/compulsions items may provide largely redundant information on the CYBOCS. Findings suggest modifying the CYBOCS to reduce burden on researchers, patients, and clinicians, and to more accurately measure pediatric obsessive-compulsive disorder (OCD).

Published
2015

32. Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.

Author

Yu, Dongmei, Mathews, Carol A, Scharf, Jeremiah M, Neale, Benjamin M, Davis, Lea K, Gamazon, Eric R, Derks, Eske M, Evans, Patrick, Edlund, Christopher K, Crane, Jacquelyn, Fagerness, Jesen A, Osiecki, Lisa, Gallagher, Patience, Gerber, Gloria, Haddad, Stephen, Illmann, Cornelia, McGrath, Lauren M, Mayerfeld, Catherine, Arepalli, Sampath, Barlassina, Cristina, Barr, Cathy L, Bellodi, Laura, Benarroch, Fortu, Berrió, Gabriel Bedoya, Bienvenu, O Joseph, Black, Donald W, Bloch, Michael H, Brentani, Helena, Bruun, Ruth D, Budman, Cathy L, Camarena, Beatriz, Campbell, Desmond D, Cappi, Carolina, Silgado, Julio C Cardona, Cavallini, Maria C, Chavira, Denise A, Chouinard, Sylvain, Cook, Edwin H, Cookson, MR, Coric, Vladimir, Cullen, Bernadette, Cusi, Daniele, Delorme, Richard, Denys, Damiaan, Dion, Yves, Eapen, Valsama, Egberts, Karin, Falkai, Peter, Fernandez, Thomas, Fournier, Eduardo, Garrido, Helena, Geller, Daniel, Gilbert, Donald L, Girard, Simon L, Grabe, Hans J, Grados, Marco A, Greenberg, Benjamin D, Gross-Tsur, Varda, Grünblatt, Edna, Hardy, John, Heiman, Gary A, Hemmings, Sian MJ, Herrera, Luis D, Hezel, Dianne M, Hoekstra, Pieter J, Jankovic, Joseph, Kennedy, James L, King, Robert A, Konkashbaev, Anuar I, Kremeyer, Barbara, Kurlan, Roger, Lanzagorta, Nuria, Leboyer, Marion, Leckman, James F, Lennertz, Leonhard, Liu, Chunyu, Lochner, Christine, Lowe, Thomas L, Lupoli, Sara, Macciardi, Fabio, Maier, Wolfgang, Manunta, Paolo, Marconi, Maurizio, McCracken, James T, Mesa Restrepo, Sandra C, Moessner, Rainald, Moorjani, Priya, Morgan, Jubel, Muller, Heike, Murphy, Dennis L, Naarden, Allan L, Nurmi, Erika, Ochoa, William Cornejo, Ophoff, Roel A, Pakstis, Andrew J, Pato, Michele T, Pato, Carlos N, Piacentini, John, Pittenger, Christopher, and Pollak, Yehuda

Subjects
Humans, Tourette Syndrome, Severity of Illness Index, Obsessive-Compulsive Disorder, Psychiatric Status Rating Scales, Comorbidity, Polymorphism, Single Nucleotide, Adult, Female, Male, Genome-Wide Association Study, Human Genome, Genetics, Brain Disorders, Serious Mental Illness, Neurodegenerative, Prevention, Anxiety Disorders, Mental Health, Neurosciences, 2.1 Biological and endogenous factors, Aetiology, Mental health, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

ObjectiveObsessive-compulsive disorder (OCD) and Tourette's syndrome are highly heritable neurodevelopmental disorders that are thought to share genetic risk factors. However, the identification of definitive susceptibility genes for these etiologically complex disorders remains elusive. The authors report a combined genome-wide association study (GWAS) of Tourette's syndrome and OCD.MethodThe authors conducted a GWAS in 2,723 cases (1,310 with OCD, 834 with Tourette's syndrome, 579 with OCD plus Tourette's syndrome/chronic tics), 5,667 ancestry-matched controls, and 290 OCD parent-child trios. GWAS summary statistics were examined for enrichment of functional variants associated with gene expression levels in brain regions. Polygenic score analyses were conducted to investigate the genetic architecture within and across the two disorders.ResultsAlthough no individual single-nucleotide polymorphisms (SNPs) achieved genome-wide significance, the GWAS signals were enriched for SNPs strongly associated with variations in brain gene expression levels (expression quantitative loci, or eQTLs), suggesting the presence of true functional variants that contribute to risk of these disorders. Polygenic score analyses identified a significant polygenic component for OCD (p=2×10(-4)), predicting 3.2% of the phenotypic variance in an independent data set. In contrast, Tourette's syndrome had a smaller, nonsignificant polygenic component, predicting only 0.6% of the phenotypic variance (p=0.06). No significant polygenic signal was detected across the two disorders, although the sample is likely underpowered to detect a modest shared signal. Furthermore, the OCD polygenic signal was significantly attenuated when cases with both OCD and co-occurring Tourette's syndrome/chronic tics were included in the analysis (p=0.01).ConclusionsPrevious work has shown that Tourette's syndrome and OCD have some degree of shared genetic variation. However, the data from this study suggest that there are also distinct components to the genetic architectures of these two disorders. Furthermore, OCD with co-occurring Tourette's syndrome/chronic tics may have different underlying genetic susceptibility compared with OCD alone.

Published
2015

36. Early intervention for obsessive compulsive disorder: An expert consensus statement

Author

Fineberg, Naomi A., Dell'Osso, Bernardo, Albert, Umberto, Maina, Giuseppe, Geller, Daniel, Carmi, Lior, Sireau, Nick, Walitza, Susanne, Grassi, Giacomo, Pallanti, Stefano, Hollander, Eric, Brakoulias, Vlasios, Menchon, Jose M., Marazziti, Donatella, Ioannidis, Konstantinos, Apergis-Schoute, Annemieke, Stein, Dan J., Cath, Danielle C., Veltman, Dick J., Van Ameringen, Michael, Fontenelle, Leonardo F., Shavitt, Roseli G., Costa, Daniel, Diniz, Juliana B., and Zohar, Joseph

Published
2019
Full Text
View/download PDF

40. Copy Number Variation in Obsessive-Compulsive Disorder and Tourette Syndrome: A Cross-Disorder Study

Author

McGrath, Lauren M, Yu, Dongmei, Marshall, Christian, Davis, Lea K, Thiruvahindrapuram, Bhooma, Li, Bingbin, Cappi, Carolina, Gerber, Gloria, Wolf, Aaron, Schroeder, Frederick A, Osiecki, Lisa, O'Dushlaine, Colm, Kirby, Andrew, Illmann, Cornelia, Haddad, Stephen, Gallagher, Patience, Fagerness, Jesen A, Barr, Cathy L, Bellodi, Laura, Benarroch, Fortu, Bienvenu, O Joseph, Black, Donald W, Bloch, Michael H, Bruun, Ruth D, Budman, Cathy L, Camarena, Beatriz, Cath, Danielle C, Cavallini, Maria C, Chouinard, Sylvain, Coric, Vladimir, Cullen, Bernadette, Delorme, Richard, Denys, Damiaan, Derks, Eske M, Dion, Yves, Rosário, Maria C, Eapen, Valsama, Evans, Patrick, Falkai, Peter, Fernandez, Thomas V, Garrido, Helena, Geller, Daniel, Grabe, Hans J, Grados, Marco A, Greenberg, Benjamin D, Gross-Tsur, Varda, Grünblatt, Edna, Heiman, Gary A, Hemmings, Sian MJ, Herrera, Luis D, Hounie, Ana G, Jankovic, Joseph, Kennedy, James L, King, Robert A, Kurlan, Roger, Lanzagorta, Nuria, Leboyer, Marion, Leckman, James F, Lennertz, Leonhard, Lochner, Christine, Lowe, Thomas L, Lyon, Gholson J, Macciardi, Fabio, Maier, Wolfgang, McCracken, James T, McMahon, William, Murphy, Dennis L, Naarden, Allan L, Neale, Benjamin M, Nurmi, Erika, Pakstis, Andrew J, Pato, Michele T, Pato, Carlos N, Piacentini, John, Pittenger, Christopher, Pollak, Yehuda, Reus, Victor I, Richter, Margaret A, Riddle, Mark, Robertson, Mary M, Rosenberg, David, Rouleau, Guy A, Ruhrmann, Stephan, Sampaio, Aline S, Samuels, Jack, Sandor, Paul, Sheppard, Brooke, Singer, Harvey S, Smit, Jan H, Stein, Dan J, Tischfield, Jay A, Vallada, Homero, Veenstra-VanderWeele, Jeremy, Walitza, Susanne, Wang, Ying, Wendland, Jens R, Shugart, Yin Yao, Miguel, Euripedes C, Nicolini, Humberto, and Oostra, Ben A

Subjects
Human Genome, Genetics, Brain Disorders, Serious Mental Illness, Neurodegenerative, Mental Health, Tourette Syndrome, Neurosciences, Intellectual and Developmental Disabilities (IDD), Aetiology, 2.1 Biological and endogenous factors, Mental health, Adolescent, DNA Copy Number Variations, Diagnostic and Statistical Manual of Mental Disorders, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Obsessive-Compulsive Disorder, Polymorphism, Single Nucleotide, Tourette syndrome, obsessive-compulsive disorder, copy number variation, genetics, 16p13.11, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental & Child Psychology
Abstract

ObjectiveObsessive-compulsive disorder (OCD) and Tourette syndrome (TS) are heritable neurodevelopmental disorders with a partially shared genetic etiology. This study represents the first genome-wide investigation of large (>500 kb), rare (

Published
2014

41. A Family Genetic Study of Obsessive Compulsive Disorder in Youth.

Author

Geller, Daniel A. and Grossman, Mia

Subjects
OBSESSIVE-compulsive disorder, TOURETTE syndrome, TIC disorders, COMORBIDITY, PATHOLOGICAL psychology
Abstract

Objective: To use a family genetic study to evaluate familial risk of obsessive compulsive disorder (OCD) and common comorbid illnesses in first-degree relatives of pediatric-onset probands with primary OCD. Method: One hundred and thirty youth with OCD and their 133 siblings and 241 parents and 49 pediatric controls were directly evaluated along multiple domains including psychopathology using structured diagnostic interviews and clinical corroboration. Results: Rates of anxiety, mood, disruptive behavior, and tic disorders were markedly elevated in the probands while rates in siblings were elevated at rates between the probands and controls. Twenty six percent of first-degree relatives had clinical OCD, 9% had chronic tics or Tourette's disorder, and 21% met criteria for ADHD. Conclusion: Rates of familial transmission of OCD and common comorbid illnesses were significantly higher in our pediatric-onset probands than rates reported in the literature in relatives of those with adult-onset OCD. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

45. Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture

Author

Davis, Lea K, Yu, Dongmei, Keenan, Clare L, Gamazon, Eric R, Konkashbaev, Anuar I, Derks, Eske M, Neale, Benjamin M, Yang, Jian, Lee, S. Hong, Evans, Patrick, Barr, Cathy L, Bellodi, Laura, Benarroch, Fortu, Berrio, Gabriel Bedoya, Bienvenu, Oscar J, Bloch, Michael H, Blom, Rianne M, Bruun, Ruth D, Budman, Cathy L, Camarena, Beatriz, Campbell, Desmond, Cappi, Carolina, Cardona Silgado, Julio C, Cath, Danielle C, Cavallini, Maria C, Chavira, Denise A, Chouinard, Sylvain, Conti, David V, Cook, Edwin H, Coric, Vladimir, Cullen, Bernadette A, Deforce, Dieter, Delorme, Richard, Dion, Yves, Edlund, Christopher K, Egberts, Karin, Falkai, Peter, Fernandez, Thomas V, Gallagher, Patience J, Garrido, Helena, Geller, Daniel, Girard, Simon L, Grabe, Hans J, Grados, Marco A, Greenberg, Benjamin D, Gross-Tsur, Varda, Haddad, Stephen, Heiman, Gary A, Hemmings, Sian M. J, Hounie, Ana G, Illmann, Cornelia, Jankovic, Joseph, Jenike, Michael A, Kennedy, James L, King, Robert A, Kremeyer, Barbara, Kurlan, Roger, Lanzagorta, Nuria, Leboyer, Marion, Leckman, James F, Lennertz, Leonhard, Liu, Chunyu, Lochner, Christine, Lowe, Thomas L, Macciardi, Fabio, McCracken, James T, McGrath, Lauren M, Mesa Restrepo, Sandra C, Moessner, Rainald, Morgan, Jubel, Muller, Heike, Murphy, Dennis L, Naarden, Allan L, Ochoa, William Cornejo, Ophoff, Roel A, Osiecki, Lisa, Pakstis, Andrew J, Pato, Michele T, Pato, Carlos N, Piacentini, John, Pittenger, Christopher, Pollak, Yehuda, Rauch, Scott L, Renner, Tobias J, Reus, Victor I, Richter, Margaret A, Riddle, Mark A, Robertson, Mary M, Romero, Roxana, Rosàrio, Maria C, Rosenberg, David, Rouleau, Guy A, Ruhrmann, Stephan, Ruiz-Linares, Andres, Sampaio, Aline S, Samuels, Jack, Sandor, Paul, Sheppard, Brooke, Singer, Harvey S, and Smit, Jan H

Subjects
Missing Heritability, Tic Disorders, Neuropsychiatric Disorders, Complex Diseases, Common Snps, Gilles, Family, Brain, Expression, Autism
Published
2013

46. Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.

Author

Chouinard, Sylvain, Conti, David, Cook, Edwin, Coric, Vladimir, Cullen, Bernadette, Deforce, Dieter, Delorme, Richard, Dion, Yves, Edlund, Christopher, Egberts, Karin, Falkai, Peter, Fernandez, Thomas, Gallagher, Patience, Garrido, Helena, Geller, Daniel, Girard, Simon, Grabe, Hans, Grados, Marco, Greenberg, Benjamin, Gross-Tsur, Varda, Haddad, Stephen, Heiman, Gary, Hemmings, Sian, Hounie, Ana, Illmann, Cornelia, Jankovic, Joseph, Jenike, Michael, Kennedy, James, King, Robert, Kremeyer, Barbara, Kurlan, Roger, Lanzagorta, Nuria, Leboyer, Marion, Leckman, James, Lennertz, Leonhard, Liu, Chunyu, Lochner, Christine, Davis, Lea, Yu, Dongmei, Keenan, Clare, Gamazon, Eric, Konkashbaev, Anuar, Derks, Eske, Neale, Benjamin, Yang, Jian, Lee, S, Evans, Patrick, Barr, Cathy, Bellodi, Laura, Benarroch, Fortu, Berrio, Gabriel, Bienvenu, Oscar, Bloch, Michael, Blom, Rianne, Bruun, Ruth, Budman, Cathy, Camarena, Beatriz, Campbell, Desmond, Cappi, Carolina, Cardona Silgado, Julio, Cath, Danielle, Cavallini, Maria, McCracken, James, McGrath, Lauren, Mesa Restrepo, Sandra, Moessner, Rainald, Morgan, Jubel, Muller, Heike, Murphy, Dennis, Naarden, Allan, Ochoa, William, Osiecki, Lisa, Pakstis, Andrew, Pato, Michele, Pato, Carlos, Pittenger, Christopher, Pollak, Yehuda, Rauch, Scott, Renner, Tobias, Richter, Margaret, Riddle, Mark, Robertson, Mary, Romero, Roxana, Rosàrio, Maria, Rosenberg, David, Rouleau, Guy, Ruhrmann, Stephan, Ruiz-Linares, Andres, Sampaio, Aline, Samuels, Jack, Sandor, Paul, Sheppard, Brooke, Singer, Harvey, Smit, Jan, Stein, Dan, Strengman, E, Tischfield, Jay, Valencia Duarte, Ana, Vallada, Homero, and Van Nieuwerburgh, Filip

Subjects
Gene Frequency, Genome-Wide Association Study, Humans, Obsessive-Compulsive Disorder, Phenotype, Polymorphism, Single Nucleotide, Quantitative Trait, Heritable, Tourette Syndrome
Abstract

The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify heritability attributable to all interrogated variants. We have quantified the variance in liability to disease explained by all SNPs for two phenotypically-related neurobehavioral disorders, obsessive-compulsive disorder (OCD) and Tourette Syndrome (TS), using GCTA. Our analysis yielded a heritability point estimate of 0.58 (se = 0.09, p = 5.64e-12) for TS, and 0.37 (se = 0.07, p = 1.5e-07) for OCD. In addition, we conducted multiple genomic partitioning analyses to identify genomic elements that concentrate this heritability. We examined genomic architectures of TS and OCD by chromosome, MAF bin, and functional annotations. In addition, we assessed heritability for early onset and adult onset OCD. Among other notable results, we found that SNPs with a minor allele frequency of less than 5% accounted for 21% of the TS heritability and 0% of the OCD heritability. Additionally, we identified a significant contribution to TS and OCD heritability by variants significantly associated with gene expression in two regions of the brain (parietal cortex and cerebellum) for which we had available expression quantitative trait loci (eQTLs). Finally we analyzed the genetic correlation between TS and OCD, revealing a genetic correlation of 0.41 (se = 0.15, p = 0.002). These results are very close to previous heritability estimates for TS and OCD based on twin and family studies, suggesting that very little, if any, heritability is truly missing (i.e., unassayed) from TS and OCD GWAS studies of common variation. The results also indicate that there is some genetic overlap between these two phenotypically-related neuropsychiatric disorders, but suggest that the two disorders have distinct genetic architectures.

Published
2013

Catalog

Books, media, physical & digital resources
See catalog results