165 results on '"Gelardi, Fabrizia"'
Search Results
2. Smaller is better? Compact vs. Conventional gamma camera for sentinel lymph node localization in patients with breast cancer
- Author
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Lazar, Alexandra, Gelardi, Fabrizia, Sagona, Andrea, Rodari, Marcello, Leonardi, Lorenzo, Massari, Roberto, D’Elia, Annunziata, Soluri, Andrea, Chiti, Arturo, and Antunovic, Lidija
- Published
- 2024
- Full Text
- View/download PDF
3. The wings of progress: technological and radiopharmaceutical innovations in nuclear medicine
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Ninatti, Gaia, Pini, Cristiano, Lazar, Alexandra, and Gelardi, Fabrizia
- Published
- 2024
- Full Text
- View/download PDF
4. Challenging the significance of SUV-based parameters in a large-scale retrospective study on lung lesions
- Author
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Pini, Cristiano, Kirienko, Margarita, Gelardi, Fabrizia, Bossi, Paola, Rahal, Daoud, Toschi, Luca, Ninatti, Gaia, Rodari, Marcello, Marulli, Giuseppe, Antunovic, Lidija, Chiti, Arturo, Voulaz, Emanuele, and Sollini, Martina
- Published
- 2024
- Full Text
- View/download PDF
5. Empowering PET: harnessing deep learning for improved clinical insight
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Artesani, Alessia, Bruno, Alessandro, Gelardi, Fabrizia, and Chiti, Arturo
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- 2024
- Full Text
- View/download PDF
6. From pixels to predictions: the scrying power of molecular imaging
- Author
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Ninatti, Gaia, Pini, Cristiano, Gelardi, Fabrizia, and Sollini, Martina
- Published
- 2024
- Full Text
- View/download PDF
7. Cutting back on overdiagnosis – Occam’s Razor and unspecific bone uptakes in PSMA PET
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Pini, Cristiano, Ninatti, Gaia, Gelardi, Fabrizia, Sollini, Martina, and Chiti, Arturo
- Published
- 2024
- Full Text
- View/download PDF
8. New actors in prostate cancer surgical theatre: are we sharpening the eye with optical imaging?
- Author
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Gelardi, Fabrizia and Antunovic, Lidija
- Published
- 2024
- Full Text
- View/download PDF
9. The potential role of osteoporosis in unspecific [18F]PSMA-1007 bone uptake
- Author
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Ninatti, Gaia, Pini, Cristiano, Gelardi, Fabrizia, Ghezzo, Samuele, Mapelli, Paola, Picchio, Maria, Antunovic, Lidija, Briganti, Alberto, Montorsi, Francesco, Landoni, Claudio, Sollini, Martina, and Chiti, Arturo
- Published
- 2023
- Full Text
- View/download PDF
10. Biological characterization of renal masses using immuno-PET
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Gelardi, Fabrizia, Larcher, Alessandro, Antunovic, Lidija, Capitanio, Umberto, Salonia, Andrea, and Chiti, Arturo
- Published
- 2024
- Full Text
- View/download PDF
11. The prognostic power of [11C]methionine PET in IDH-wildtype diffuse gliomas with lower-grade histological features: venturing beyond WHO classification
- Author
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Ninatti, Gaia, Pini, Cristiano, Bono, Beatrice Claudia, Gelardi, Fabrizia, Antunovic, Lidija, Fernandes, Bethania, Sollini, Martina, Landoni, Claudio, Chiti, Arturo, and Pessina, Federico
- Published
- 2023
- Full Text
- View/download PDF
12. European guidelines update on PSMA PET/CT for prostate cancer staging—snap back to reality
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Gelardi, Fabrizia, Briganti, Alberto, Pini, Cristiano, Ninatti, Gaia, Gandaglia, Giorgio, Montorsi, Francesco, and Chiti, Arturo
- Published
- 2023
- Full Text
- View/download PDF
13. Now you see me: lights on Merkel Cell Carcinoma
- Author
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Pini, Cristiano, Matassa, Giovanni, Gelardi, Fabrizia, and Antunovic, Lidija
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- 2023
- Full Text
- View/download PDF
14. Multimodality Imaging in the Study of the Urinary Tract
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Gennaro, Nicolò, Muglia, Riccardo, Gelardi, Fabrizia, Piccoli, Francesca, Chiti, Arturo, Neri, Emanuele, editor, and Erba, Paola Anna, editor
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- 2023
- Full Text
- View/download PDF
15. COVID-19 vaccination, implications for PET/CT image interpretation and future perspectives
- Author
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Kirienko, Margarita, Biroli, Matteo, Pini, Cristiano, Gelardi, Fabrizia, Sollini, Martina, and Chiti, Arturo
- Published
- 2022
- Full Text
- View/download PDF
16. Molecular Guidance for Planning External Beam Radiation Therapy in Oncology
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Fiz, Francesco, Iori, Mauro, Fioroni, Federica, Biroli, Matteo, D’Agostino, Giuseppe Roberto, Gelardi, Fabrizia, Erba, Paola A., Versari, Annibale, Chiti, Arturo, Sollini, Martina, Volterrani, Duccio, editor, Erba, Paola A., editor, Strauss, H. William, editor, Mariani, Giuliano, editor, and Larson, Steven M., editor
- Published
- 2022
- Full Text
- View/download PDF
17. Present and future of target therapies and theranostics: refining traditions and exploring new frontiers—highlights from annals of Nuclear Medicine 2021
- Author
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Pini, Cristiano, Gelardi, Fabrizia, and Sollini, Martina
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- 2022
- Full Text
- View/download PDF
18. Immuno-PET/CT Imaging of Trop2 with [18F]AlF-RESCA-T4 Differentiates Lung Cancer from Inflammation.
- Author
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Huang, Wei, Cao, Min, Wu, Yanfei, Zhang, You, An, Shuxian, Pan, Xinbing, Zhou, Xinyuan, Shao, Hongda, Guan, Yihui, Huang, Gang, Gelardi, Fabrizia, Chiti, Arturo, Xie, Fang, Liu, Jianjun, and Wei, Weijun
- Published
- 2024
- Full Text
- View/download PDF
19. Patients’ findings after COVID-19 infection and vaccinations: what to expect from [18F]FDG PET/CT
- Author
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Sollini, Martina, Gelardi, Fabrizia, Biroli, Matteo, and Chiti, Arturo
- Published
- 2022
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20. PD19-12 THE ROLE OF PSMA PET/CT IN PREDICTING PATHOLOGICAL LOCAL STAGING AND GRADING FOR PROSTATE CANCER
- Author
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Piccolini, Andrea, primary, Chiarelli, Giuseppe, additional, Arena, Paola, additional, Fasulo, Vittorio, additional, Dagnino, Filippo, additional, Frego, Nicola, additional, Casale, Paolo, additional, Saita, Alberto, additional, Lazzeri, Massimo, additional, Hurle, Rodolfo, additional, Buffi, Nicolò, additional, Gelardi, Fabrizia, additional, Jandric, Jelena, additional, Muraglia, Lorenzo, additional, Rodari, Marcello, additional, Evangelista, Laura, additional, and Lughezzani, Giovanni, additional
- Published
- 2024
- Full Text
- View/download PDF
21. State-of-the-art of FAPI-PET imaging: a systematic review and meta-analysis
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Sollini, Martina, Kirienko, Margarita, Gelardi, Fabrizia, Fiz, Francesco, Gozzi, Noemi, and Chiti, Arturo
- Published
- 2021
- Full Text
- View/download PDF
22. Long COVID hallmarks on [18F]FDG-PET/CT: a case-control study
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Sollini, Martina, Morbelli, Silvia, Ciccarelli, Michele, Cecconi, Maurizio, Aghemo, Alessio, Morelli, Paola, Chiola, Silvia, Gelardi, Fabrizia, and Chiti, Arturo
- Published
- 2021
- Full Text
- View/download PDF
23. Women on board: mind the (gender) gap
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Gelardi, Fabrizia and Gozzi, Noemi
- Published
- 2021
- Full Text
- View/download PDF
24. Climbing the steps of the evidence-based medicine pyramid: highlights from Annals of Nuclear Medicine 2019
- Author
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Gelardi, Fabrizia, Kirienko, Margarita, and Sollini, Martina
- Published
- 2021
- Full Text
- View/download PDF
25. Vasculitis changes in COVID-19 survivors with persistent symptoms: an [18F]FDG-PET/CT study
- Author
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Sollini, Martina, Ciccarelli, Michele, Cecconi, Maurizio, Aghemo, Alessio, Morelli, Paola, Gelardi, Fabrizia, and Chiti, Arturo
- Published
- 2021
- Full Text
- View/download PDF
26. The Predictive Role of Radiomics in Breast Cancer Patients Imaged by [ 18 F]FDG PET: Preliminary Results from a Prospective Cohort.
- Author
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Gelardi, Fabrizia, Cavinato, Lara, De Sanctis, Rita, Ninatti, Gaia, Tiberio, Paola, Rodari, Marcello, Zambelli, Alberto, Santoro, Armando, Fernandes, Bethania, Chiti, Arturo, Antunovic, Lidija, and Sollini, Martina
- Subjects
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PATHOLOGIC complete response , *CANCER chemotherapy , *RADIOMICS , *PRINCIPAL components analysis , *NEOADJUVANT chemotherapy - Abstract
Background: Recently, radiomics has emerged as a possible image-derived biomarker, predominantly stemming from retrospective analyses. We aimed to prospectively assess the predictive role of [18F]FDG-PET radiomics in breast cancer (BC). Methods: Patients affected by stage I–III BC eligible for neoadjuvant chemotherapy (NAC) staged with [18F]FDG-PET/CT were prospectively enrolled. The pathological response to NAC was assessed on surgical specimens. From each primary breast lesion, we extracted radiomic PET features and their predictive role with respect to pCR was assessed. Uni- and multivariate statistics were used for inference; principal component analysis (PCA) was used for dimensionality reduction. Results: We analysed 93 patients (53 HER2+ and 40 triple-negative (TNBC)). pCR was achieved in 44/93 cases (24/53 HER2+ and 20/40 TNBC). Age, molecular subtype, Ki67 percent, and stage could not predict pCR in multivariate analysis. In univariate analysis, 10 radiomic indices resulted in p < 0.1. We found that 3/22 radiomic principal components were discriminative for pCR. Using a cross-validation approach, radiomic principal components failed to discriminate pCR groups but predicted the stage (mean accuracy = 0.79 ± 0.08). Conclusions: This study shows the potential of PET radiomics for staging purposes in BC; the possible role of radiomics in predicting the pCR response to NAC in BC needs to be further investigated. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
27. Match Point: Nuclear Medicine Imaging for Recurrent Thyroid Cancer in TENIS Syndrome—Systematic Review and Meta-Analysis.
- Author
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Gelardi, Fabrizia, Lazar, Alexandra, Ninatti, Gaia, Pini, Cristiano, Chiti, Arturo, Luster, Markus, Eilsberger, Friederike, and Sollini, Martina
- Subjects
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WHOLE body imaging , *THERAPEUTICS , *DISEASE relapse , *NUCLEAR medicine , *DRUG target , *THYROID cancer - Abstract
Background/Objectives: Disease recurrence and resistance to radioiodine (RAI) therapy are major challenges in the management of differentiated thyroid cancer (DTC). In particular, the TENIS (Thyroglobulin Elevated Negative Iodine Scintigraphy) syndrome, characterised by elevated thyroglobulin (Tg) serum levels in addition to a negative radioiodine whole body scan (WBS), complicates disease monitoring and treatment decisions. Conventional imaging techniques often fail to detect disease in WBS-negative patients with rising Tg levels, leading to limitations in therapeutic intervention. This systematic review and meta-analysis aims to evaluate the diagnostic accuracy of nuclear imaging modalities in detecting disease recurrence in patients with the TENIS syndrome and to provide insights to guide therapeutic approaches in this complex clinical scenario. Methods: A comprehensive search of PubMed/MEDLINE and EMBASE databases up to March 2024 was performed according to PRISMA guidelines. Eligible studies were selected, and quality assessment was performed with the QUADAS-2 tool. For each study, relevant data were extracted and synthesised. A meta-analysis of the diagnostic accuracy of [18F]FDG PET/CT was performed, and patient-based pooled sensitivity and specificity were calculated using a random-effects model. Statistical heterogeneity between studies was assessed using the I2 statistic. Results: Of the 538 studies initially identified, 22 were included in the systematic review, of which 18 were eligible for meta-analysis. The eligible studies, mainly focused on [18F]FDG PET/CT, showed variable sensitivity and specificity for the detection of RAI-refractory thyroid cancer lesions. For [18F]FDG PET/CT, pooled estimates displayed a sensitivity of 0.87 (95% CI: 0.82–0.90) and a specificity of 0.76 (95% CI: 0.61–0.86), with moderate heterogeneity between studies. Conclusions: [18F]FDG PET/CT remains central in the detection of disease recurrence in patients with the TENIS syndrome. The emergence of novel radiopharmaceuticals with specific molecular targets is a promising way to overcome the limitations of [18F]FDG in these patients and to open new theranostics perspectives. This review highlights the great potential of nuclear medicine in guiding therapeutic strategies for RAI-refractory thyroid cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
28. Interdisciplinarity: an essential requirement for translation of radiomics research into clinical practice – a systematic review focused on thoracic oncology
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Sollini, Martina, Gelardi, Fabrizia, Matassa, Giovanni, Delgado Bolton, Roberto C., Chiti, Arturo, and Kirienko, Margarita
- Published
- 2020
- Full Text
- View/download PDF
29. Deep learning in Nuclear Medicine—focus on CNN-based approaches for PET/CT and PET/MR: where do we stand?
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Kirienko, Margarita, Biroli, Matteo, Gelardi, Fabrizia, Seregni, Ettore, Chiti, Arturo, and Sollini, Martina
- Published
- 2021
- Full Text
- View/download PDF
30. Morphometric vertebral fractures in patients with castration-resistant prostate cancer undergoing treatment with radium-223: a longitudinal study in the real-life clinical practice
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Mazziotti, Gherardo, Rodari, Marcello, Gelardi, Fabrizia, Tosi, Giovanni, Zucali, Paolo A., Pepe, Giovanna, and Chiti, Arturo
- Published
- 2020
- Full Text
- View/download PDF
31. Role of Metabolic Imaging in Mesothelioma
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Gelardi, Fabrizia, Marciano, Andrea, Erba, Paola Anna, Chiti, Arturo, Ceresoli, Giovanni Luca, editor, Bombardieri, Emilio, editor, and D'Incalci, Maurizio, editor
- Published
- 2019
- Full Text
- View/download PDF
32. From pixels to predictions: the scrying power of molecular imaging
- Author
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Ninatti, Gaia, primary, Pini, Cristiano, additional, Gelardi, Fabrizia, additional, and Sollini, Martina, additional
- Published
- 2023
- Full Text
- View/download PDF
33. New actors in prostate cancer surgical theatre: are we sharpening the eye with optical imaging?
- Author
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Gelardi, Fabrizia, primary and Antunovic, Lidija, additional
- Published
- 2023
- Full Text
- View/download PDF
34. Carcinoma differenziato della tiroide metastatico con riduzione di Tg e incremento della captazione 18F-FDG-PET: evoluzione verso la radioiodio refrattarietà?
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Cellini, Miriam, Pepe, Giovanna, Cozzaglio, Luca, Gelardi, Fabrizia, and Colombo, Paolo
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- 2020
- Full Text
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35. Early Experiences on using Triplet Networks for Histological Subtype Classification in Non-Small Cell Lung Cancer
- Author
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Aksu, Fatih, Gelardi, Fabrizia, Chiti, Arturo, Soda, Paolo, Aksu, Fatih, Gelardi, Fabrizia, Chiti, Arturo, and Soda, Paolo
- Abstract
Lung cancer has the highest mortality rate among tumours and an accurate pathological assessment is crucial to deliver personalized treatments to patients. The gold standard for pathological assessment requires invasive procedures, which are not always possible and might cause clinical complications. Therefore, in the last years, efforts have been directed towards the development of machine and deep learning approaches for virtual biopsy, which leverage routinely collected CT scans. However, in many cases, the available datasets are limited in size, an issue that limits the training of any model. In this paper, we investigate if triplet networks can cope with this limitation: they are a class of neural networks that uses the same weights while working in tandem on three different input vectors to minimize the loss function. In particular, on a dataset including 87 CT scans collected from patients suffering from non-small cell lung cancer, we experimentally compare triplet networks against plain deep networks when performing histological subtype classification. The results show that the former outperforms the latter in almost all experiments.
- Published
- 2023
- Full Text
- View/download PDF
36. The potential role of osteoporosis in unspecific [18F]PSMA-1007 bone uptake
- Author
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Ninatti, G, Pini, C, Gelardi, F, Ghezzo, S, Mapelli, P, Picchio, M, Antunovic, L, Briganti, A, Montorsi, F, Landoni, C, Sollini, M, Chiti, A, Ninatti, Gaia, Pini, Cristiano, Gelardi, Fabrizia, Ghezzo, Samuele, Mapelli, Paola, Picchio, Maria, Antunovic, Lidija, Briganti, Alberto, Montorsi, Francesco, Landoni, Claudio, Sollini, Martina, Chiti, Arturo, Ninatti, G, Pini, C, Gelardi, F, Ghezzo, S, Mapelli, P, Picchio, M, Antunovic, L, Briganti, A, Montorsi, F, Landoni, C, Sollini, M, Chiti, A, Ninatti, Gaia, Pini, Cristiano, Gelardi, Fabrizia, Ghezzo, Samuele, Mapelli, Paola, Picchio, Maria, Antunovic, Lidija, Briganti, Alberto, Montorsi, Francesco, Landoni, Claudio, Sollini, Martina, and Chiti, Arturo
- Abstract
Aim: Unspecific bone uptake is one of the main limitations of PET imaging with some PSMA-targeting radiopharmaceuticals, especially with [18F]PSMA-1007. We explored the potential association between osteoporosis and the occurrence of unspecific [18F]PSMA-1007 bone uptake investigating markers which might correlate with bone mineral density. Materials and methods: We retrospectively analyzed treatment-naïve patients with a confirmed diagnosis of prostate adenocarcinoma who underwent staging [18F]PSMA-1007 positron emission tomography (PET). Qualitative image analysis was performed independently by three experienced nuclear medicine physicians. Patients were divided in two groups according to the presence/absence of unspecific bone uptake. Clinical information, blood count parameters (assessed within 3 months to the PET scan), body mass index (BMI), and bone density as estimated by computed tomography were collected. The Kruskal–Wallis and t-test were used to compare parameters. Results: We analyzed 77 patients: 29 of them (38%) had unspecific bone uptake at [18F]PSMA-1007 PET, most commonly in the pelvic bones (69%) and ribs (62%). We did not find any significant difference in clinical parameters in the two groups. In patients with unspecific bone uptake, white blood cell, and neutrophil counts were significantly higher; in the same group, we observed lower values of BMI and bone density, although not statistically different. Conclusions: We observed unspecific bone uptake on [18F]PSMA-1007 PET in more than 1/3 of patients. In this exploratory analysis, we found a significant correlation between blood count parameters and unspecific [18F]PSMA-1007 bone uptake. We may speculate that [18F]PSMA-1007 unspecific bone uptake could be associated with osteoporosis. This hypothesis needs to be further investigated in larger populations and exploring more specific markers of osteoporosis.
- Published
- 2023
37. The prognostic power of [11C]methionine PET in IDH-wildtype diffuse gliomas with lower-grade histological features: venturing beyond WHO classification
- Author
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Ninatti, G, Pini, C, Bono, B, Gelardi, F, Antunovic, L, Fernandes, B, Sollini, M, Landoni, C, Chiti, A, Pessina, F, Ninatti, Gaia, Pini, Cristiano, Bono, Beatrice Claudia, Gelardi, Fabrizia, Antunovic, Lidija, Fernandes, Bethania, Sollini, Martina, Landoni, Claudio, Chiti, Arturo, Pessina, Federico, Ninatti, G, Pini, C, Bono, B, Gelardi, F, Antunovic, L, Fernandes, B, Sollini, M, Landoni, C, Chiti, A, Pessina, F, Ninatti, Gaia, Pini, Cristiano, Bono, Beatrice Claudia, Gelardi, Fabrizia, Antunovic, Lidija, Fernandes, Bethania, Sollini, Martina, Landoni, Claudio, Chiti, Arturo, and Pessina, Federico
- Abstract
Purpose: IDH-wildtype (IDH-wt) diffuse gliomas with histological features of lower-grade gliomas (LGGs) are rare and heterogeneous primary brain tumours. [11C]Methionine (MET) positron emission tomography (PET) is commonly used to evaluate glial neoplasms at diagnosis. The present study aimed to assess the prognostic value of MET PET in newly diagnosed, treatment naïve IDH-wt gliomas with histological features of LGGs. Methods: Patients with a histological diagnosis of IDH-wt LGG who underwent preoperative (< 100 days) MET PET/CT and surgery were retrospectively included. Qualitative and semi-quantitative analyses of MET PET images were performed. Progression-free survival (PFS) and overall survival (OS) were analysed by Kaplan–Meier curves. Cox proportional-hazards regression was used to test the association of imaging and clinical data to PFS and OS. Results: We included 48 patients (M:F = 25:23; median age 55). 39 lesions were positive and 9 negative at MET PET. Positive MET PET was significantly associated with shorter median PFS (15.7 months vs. not reached, p = 0.0146) and OS time (32.6 months vs. not reached, p = 0.0253). Incomplete surgical resection and higher TBRmean values were independent predictors of shorter PFS on multivariate analysis (p < 0.001 for both). Higher tumour grade and incomplete surgical resection were independent predictors of OS at multivariate analysis (p = 0.027 and p = 0.01, respectively). Conclusion: MET PET is useful for the prognostic stratification of patients with IDH-wt glial neoplasms with histological LGGs features. Considering their huge biological heterogeneity, the combination of MET PET and molecular analyses may help to improve the prognostic accuracy in these diffuse gliomas subset and influence therapeutic choices accordingly.
- Published
- 2023
38. The potential role of osteoporosis in unspecific [18F]PSMA-1007 bone uptake.
- Author
-
Ninatti, Gaia, Pini, Cristiano, Gelardi, Fabrizia, Ghezzo, Samuele, Mapelli, Paola, Picchio, Maria, Antunovic, Lidija, Briganti, Alberto, Montorsi, Francesco, Landoni, Claudio, Sollini, Martina, and Chiti, Arturo
- Subjects
POSITRON emission tomography ,LEUCOCYTES ,OSTEOPOROSIS ,BONE density ,IMAGE analysis ,BODY mass index ,ANIMAL population density ,PLATELET count - Abstract
Aim: Unspecific bone uptake is one of the main limitations of PET imaging with some PSMA-targeting radiopharmaceuticals, especially with [
18 F]PSMA-1007. We explored the potential association between osteoporosis and the occurrence of unspecific [18 F]PSMA-1007 bone uptake investigating markers which might correlate with bone mineral density. Materials and methods: We retrospectively analyzed treatment-naïve patients with a confirmed diagnosis of prostate adenocarcinoma who underwent staging [18 F]PSMA-1007 positron emission tomography (PET). Qualitative image analysis was performed independently by three experienced nuclear medicine physicians. Patients were divided in two groups according to the presence/absence of unspecific bone uptake. Clinical information, blood count parameters (assessed within 3 months to the PET scan), body mass index (BMI), and bone density as estimated by computed tomography were collected. The Kruskal–Wallis and t-test were used to compare parameters. Results: We analyzed 77 patients: 29 of them (38%) had unspecific bone uptake at [18 F]PSMA-1007 PET, most commonly in the pelvic bones (69%) and ribs (62%). We did not find any significant difference in clinical parameters in the two groups. In patients with unspecific bone uptake, white blood cell, and neutrophil counts were significantly higher; in the same group, we observed lower values of BMI and bone density, although not statistically different. Conclusions: We observed unspecific bone uptake on [18 F]PSMA-1007 PET in more than 1/3 of patients. In this exploratory analysis, we found a significant correlation between blood count parameters and unspecific [18 F]PSMA-1007 bone uptake. We may speculate that [18 F]PSMA-1007 unspecific bone uptake could be associated with osteoporosis. This hypothesis needs to be further investigated in larger populations and exploring more specific markers of osteoporosis. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
39. MP55-03 CORRELATION BETWEEN PSMA PET/CT DATA AND PATHOLOGICAL TUMOUR STAGING AND GRADING OF PROSTATE CANCER
- Author
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Chiarelli, Giuseppe, primary, Arena, Paola, additional, Fasulo, Vittorio, additional, Frego, Nicola, additional, De Carne, Fabio, additional, Maffei, Davide, additional, Jandric, Jelena, additional, Gelardi, Fabrizia, additional, Garofano, Giuseppe, additional, Mancon, Stefano, additional, Saitta, Cesare, additional, Sordelli, Federica, additional, Beatrici, Edoardo, additional, Guazzoni, Giorgio, additional, Emanuele, Pieve, additional, Hurle, Rodolfo, additional, Saita, Alberto, additional, Lazzeri, Massimo, additional, Buffi, Nicolò Maria, additional, Lughezzani, Giovanni, additional, and Casale, Paolo, additional
- Published
- 2023
- Full Text
- View/download PDF
40. The Role of PET Imaging in the Differential Diagnosis between Radiation Necrosis and Recurrent Disease in Irradiated Adult-Type Diffuse Gliomas: A Systematic Review
- Author
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Ninatti, Gaia, primary, Pini, Cristiano, additional, Gelardi, Fabrizia, additional, Sollini, Martina, additional, and Chiti, Arturo, additional
- Published
- 2023
- Full Text
- View/download PDF
41. The prognostic power of [11C]methionine PET in IDH-wildtype diffuse gliomas with lower-grade histological features: venturing beyond WHO classification.
- Author
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Ninatti, Gaia, Pini, Cristiano, Bono, Beatrice Claudia, Gelardi, Fabrizia, Antunovic, Lidija, Fernandes, Bethania, Sollini, Martina, Landoni, Claudio, Chiti, Arturo, and Pessina, Federico
- Abstract
Purpose: IDH-wildtype (IDH-wt) diffuse gliomas with histological features of lower-grade gliomas (LGGs) are rare and heterogeneous primary brain tumours. [
11 C]Methionine (MET) positron emission tomography (PET) is commonly used to evaluate glial neoplasms at diagnosis. The present study aimed to assess the prognostic value of MET PET in newly diagnosed, treatment naïve IDH-wt gliomas with histological features of LGGs. Methods: Patients with a histological diagnosis of IDH-wt LGG who underwent preoperative (< 100 days) MET PET/CT and surgery were retrospectively included. Qualitative and semi-quantitative analyses of MET PET images were performed. Progression-free survival (PFS) and overall survival (OS) were analysed by Kaplan–Meier curves. Cox proportional-hazards regression was used to test the association of imaging and clinical data to PFS and OS. Results: We included 48 patients (M:F = 25:23; median age 55). 39 lesions were positive and 9 negative at MET PET. Positive MET PET was significantly associated with shorter median PFS (15.7 months vs. not reached, p = 0.0146) and OS time (32.6 months vs. not reached, p = 0.0253). Incomplete surgical resection and higher TBRmean values were independent predictors of shorter PFS on multivariate analysis (p < 0.001 for both). Higher tumour grade and incomplete surgical resection were independent predictors of OS at multivariate analysis (p = 0.027 and p = 0.01, respectively). Conclusion: MET PET is useful for the prognostic stratification of patients with IDH-wt glial neoplasms with histological LGGs features. Considering their huge biological heterogeneity, the combination of MET PET and molecular analyses may help to improve the prognostic accuracy in these diffuse gliomas subset and influence therapeutic choices accordingly. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
42. Contrast-Enhanced Mammography versus Breast Magnetic Resonance Imaging: A Systematic Review and Meta-Analysis
- Author
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Gelardi, Fabrizia, primary, Ragaini, Elisa Maria, additional, Sollini, Martina, additional, Bernardi, Daniela, additional, and Chiti, Arturo, additional
- Published
- 2022
- Full Text
- View/download PDF
43. The complementary role of PSMA expression and [18F]FDG PET/CT in predicting thyroid cancer outcome: from black and white to shades of gray, in the era of precision oncology.
- Author
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Sollini, Martina, Kirienko, Margarita, di Tommaso, Luca, Pini, Cristiano, Gelardi, Fabrizia, Ariano, Salvatore, Lania, Andrea Gerardo, Mazziotti, Gherardo, Mercante, Giuseppe, and Chiti, Arturo
- Subjects
POSITRON emission tomography ,THYROID cancer ,CANCER prognosis ,PROGRESSION-free survival ,DISEASE relapse - Abstract
Background: The value of Prostate Specific Membrane Antigen (PSMA) in thyroid carcinoma (TC) is still unknown. We aimed to test the potential complementary role of PSMA expression and 2-[
18 F]fluoro-2-deoxy-D-glucose ([18 F]FDG) uptake on PET/CT as biomarkers for TC outcome prediction. Materials and methods: From a retrospective cohort of TC patients we selected those fulfilling the following inclusion/exclusion criteria: thyroidectomy in our Institution, available primary tumor tissue PSMA immunostaining, [18 F]FDG PET/CT and follow-up data. PSMA staining was visually assessed. PET/CT was considered positive in case of [18 F]FDG uptake higher than the background at the site of TC confirmed by cyto-/histology, and/or follow-up. Disease recurrence, radioiodine refractoriness (RAI-R) and status at last follow-up (LFU) were used as outcome endpoints. Results: We included 23 subjects. Disease recurrence occurred in 18 patients (median time 11 months, range 1–40); among these 12/18 developed RAI-R (median time 28 months, range 2–221), and 13/18 had evidence of disease at LFU. PSMA expression was negative in 6/23 cases. PET/CT was negative in 11/23 patients (7/11 experienced recurrence). PET/CT was positive in 9/12 patients showing RAI-R and 10/13 cases with evidence of disease at LFU. All patients with positive PET/CT had a positive PSMA immunostaining. Six out of 11 patients with negative PET/CT were positive at immunostaining, showing lower PSMA expression (median score of 30%, range 0–80%) than patients with positive PET/CT. The TC samples without PSMA expression belonged to patients who resulted negative also at PET/CT (3 experienced recurrence, 2 were RAI-R, and 1 had disease at LFU). Four out of 11 patients who resulted negative at PET/CT exhibited very high PSMA expression (≥ 70%) and although 3 of them experienced recurrence, none resulted RAI-R, and only 1 had persistent disease at LFU. Conclusions: Primary tumor PSMA expression and [18 F]FDG uptake seem to play a complementary prognostic role in TC. The majority of patients who expressed PSMA recurred. In the intermediate ATA risk class, patients with negative PSMA immunostaining recurred less than patients expressing PSMA. Additionally, although patients with a negative [18 F]FDG PET/CT had a favourable long-term outcome, PSMA assessment might be useful to timely identify subjects at higher risk of recurrence. [ABSTRACT FROM AUTHOR]- Published
- 2023
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44. ALBI grade for outcome prediction in patients affected by hepatocellular carcinoma treated with transarterial radioembolization
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Gelardi, Fabrizia, primary, Rodari, Marcello, additional, Pini, Cristiano, additional, Zanca, Roberta, additional, Artesani, Alessia, additional, Tosi, Giovanni, additional, Chiti, Arturo, additional, and Sollini, Martina, additional
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- 2022
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45. MP59-20 [18F]-FDG PET/CT FOR BLADDER CANCER STAGING AND DECISION-MAKING IN PATIENTS WITH HIGH-RISK NON-MUSCLE INVASIVE BLADDER CANCER (HR-NMIBC)
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Hurle, Rodolfo, primary, Casale, Paolo, additional, Saita, Alberto, additional, Buffi, NicolòMaria, additional, Lughezzani, Giovanni, additional, Contieri, Roberto, additional, Fasulo, Vittorio, additional, Frego, Nicola, additional, Benetti, Alessio, additional, Chiti, Arturo, additional, Rodari, Marcello, additional, Sollini, Martini, additional, Pini, Cristiano, additional, Gelardi, Fabrizia, additional, Guazzoni, Giorgio, additional, and Lazzeri, Massimo, additional
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- 2022
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46. Worldwide Disparities in Recovery of Cardiac Testing 1 Year Into COVID-19
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Einstein, Andrew J., primary, Hirschfeld, Cole, additional, Williams, Michelle C., additional, Vitola, Joao V., additional, Better, Nathan, additional, Villines, Todd C., additional, Cerci, Rodrigo, additional, Shaw, Leslee J., additional, Choi, Andrew D., additional, Dorbala, Sharmila, additional, Karthikeyan, Ganesan, additional, Lu, Bin, additional, Sinitsyn, Valentin, additional, Ansheles, Alexey A., additional, Kudo, Takashi, additional, Bucciarelli-Ducci, Chiara, additional, Nørgaard, Bjarne Linde, additional, Maurovich-Horvat, Pál, additional, Campisi, Roxana, additional, Milan, Elisa, additional, Louw, Lizette, additional, Allam, Adel H., additional, Bhatia, Mona, additional, Sewanan, Lorenzo, additional, Malkovskiy, Eli, additional, Cohen, Yosef, additional, Randazzo, Michael, additional, Narula, Jagat, additional, Morozova, Olga, additional, Pascual, Thomas N.B., additional, Pynda, Yaroslav, additional, Dondi, Maurizio, additional, Paez, Diana, additional, Einstein, Andrew J., additional, Hinterleitner, Gerd, additional, Lu, Yao, additional, Xu, Zhuoran, additional, Hirschfeld, Cole B., additional, Erinne, Ikenna, additional, Shetty, Mrinali, additional, Choi, Andrew, additional, Lopez-Mattei, Juan, additional, Parwani, Purvi, additional, Goda, Artan, additional, Shirka, Ervina, additional, Bouyoucef, Salah, additional, Chelghoum, Lydia, additional, Mansouri, Farouk, additional, Medjahedi, Abdelkader, additional, Naili, Qais, additional, Ridouh, Mokhtar, additional, Alasia, Diego, additional, Alberghina, Lucia, additional, Aramayo, Natalia, additional, Buchara, Diego, additional, Busso, Franco Gabriel, additional, Bustos Rivadero, Jose Javier, additional, Camilletti, Jorge, additional, Campanelli, Hugo, additional, Castro, Ricardo Belisario, additional, Daicz, Mariana, additional, del Riego, Horacio, additional, Dragonetti, Laura, additional, Echazarreta, Diego, additional, Erriest, Juan, additional, Faccio, Fernando, additional, Facello, Adolfo, additional, Gallegos, Hugo, additional, Geronazzo, Ricardo, additional, Glait, Horacio, additional, Hasbani, Victor, additional, Jäger, Victor, additional, Lewkowicz, Julio Manuel, additional, Lotti, Jose, additional, Maciel, Neiva, additional, Masoli, Osvaldo, additional, Mastrovito, Edgardo, additional, Medus, Maria, additional, Merani, Maria Fernanda, additional, Molteni, Susana, additional, Montecinos, Marcos, additional, Parisi, Gustavo, additional, Sueldo, Claudio Pereyra, additional, Perez de Arenaza, Diego, additional, Quintana, Luis, additional, Radzinschi, Alejandro, additional, Redruello, Marcela, additional, Rodríguez, Marina, additional, Rojas, Horacio, additional, Acuña, Arturo Romero, additional, Schere, Daniel, additional, Traverso, Sonia, additional, Vazquez, Gustavo, additional, Zeffiro, Susana, additional, Sakanyan, Mari, additional, Beuzeville, Scott, additional, Boktor, Raef, additional, Crowley, Michael, additional, Downie, D'Arne, additional, Dwivedi, Girish, 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additional, Øvrehus, Kristian, additional, Rasmussen, Jan, additional, Rønnow Sand, Niels Peter, additional, Sondergaard, Hanne, additional, Zaremba, Tomas, additional, Speckter, Herwin, additional, Amores, Nelson, additional, Velez, Mayra Sanchez, additional, Alrahman, Taghreed Abd, additional, Elsamad, Sherif Abd, additional, Abdelfattah, Alia, additional, Allam, Adel, additional, Elkaffas, Sameh, additional, Hassan, Mona, additional, Hussein, Elshaymaa, additional, Ibrahim, Ahmed, additional, Kandeel, Ahmed, additional, Ali, Mohamed Mandour, additional, Shaaban, Mahmoud, additional, Flores, Camila, additional, Gómez Leiva, Verónica Vanesa, additional, Liiver, Anita, additional, Larikka, Martti, additional, Uusitalo, Valtteri, additional, Agostini, Denis, additional, Berger, Clothilde, additional, Dietz, Matthieu, additional, Hyafil, Fabien, additional, Ohana, Mickaël, additional, Prigent, Kevin, additional, Regaieg, Hamza, additional, Sarda-Mantel, Laure, additional, H-Ici, Darach 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Animesh, additional, Mishra, Vivaswan Dutt, additional, Mohan, Parul, additional, Ozair, Ahmad, additional, Pandey, Shivani, additional, Parameswaran, Ramanathapuram, additional, Patel, Chetan, additional, Patel, Tapan, additional, Patel, Shivani, additional, Vimala, Leena Robinson, additional, Kumar Sarangi, Dr Pradosh, additional, Sengupta, Shantanu, additional, Sethi, Arvind, additional, Sharma, Amit, additional, Sharma, Awadhesh Kumar, additional, Sharma, Punit, additional, Shrigiriwar, Apurva, additional, Singh, Santosh, additional, Singh, Harpreet, additional, Sood, Ashwani, additional, Verma, Atul, additional, Vyas, Ajay, additional, Soeriadi, Erwin Affandi, additional, Bun, Edison, additional, Hutomo, Febby, additional, Syawaluddin, Hilman, additional, Yudistiro, Ryan, additional, Albadr, Amjed, additional, Assadi, Majid, additional, Emami, Farshad, additional, Emami-Ardekani, Alireza, additional, Farzanehfar, Saeed, additional, Jafari, Ramezan, additional, Manafi-Farid, 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Diaz, Javier Lopez, additional, Vega, Luis Lumbreras, additional, Manovel-Sánchez, Ana, additional, Monzonis, Amparo Martinez, additional, Patrut, Bianca, additional, Pubul, Virginia, additional, Perez, Ricardo Ruano, additional, Zeidan, Nahla, additional, Nanayakkara, Damayanthi, additional, Suliman, Ahmed, additional, Engblom, Henrik, additional, Murtadha, Mustafa, additional, Ostenfeld, Ellen, additional, Simonsson, Magnus, additional, Alkadhi, Hatem, additional, Buechel, Ronny Ralf, additional, Burger, Peter, additional, Gräni, Christoph, additional, Kamani, Christel, additional, Kawel-Böhm, Nadine, additional, Klaeser, Bernd, additional, Manka, Robert, additional, Prior, John, additional, Kaewchur, Tawika, additional, Khiewvan, Benjapa, additional, Kositwattanarerk, Arpakorn, additional, Namwongprom, Sirianong, additional, Thientunyakit, Tanyaluck, additional, Sayman, Haluk Burcak, additional, Yüksel, Mahmut, additional, Sebikali, Mugisha Julius, additional, Okello, Emmy, additional, Korol, Pavlo, additional, Noverko, Iryna, additional, Satyr, Maryna, additional, Ahmad, Tahir, additional, Alfakih, Khaled, additional, Andrade, Ivo, additional, Buckingham, Susan, additional, Bularga, Anda, additional, Carpenter, John-Paul, additional, Cole, Graham, additional, Cusack, David, additional, David, Sarojini, additional, Davis, Patrick, additional, Fairbairn, Timothy, additional, Ghosh, Arjun, additional, Ramkumar, Prasad Guntur, additional, Hamilton, Mark, additional, Haque, Faisal, additional, Hudson, Benjamin, additional, Johnstone, Annette, additional, Karthikeyan, V.J., additional, Kay, Mike, additional, Khan, Mohammad Ali, additional, Kitt, Jamie, additional, Low, Chen Sheng, additional, Mcalindon, Elisa, additional, Mccreavy, David, additional, Morrissey, Brian, additional, Motwani, Manish, additional, Na, Dilip, additional, Nicol, Edward, additional, Patel, Dilip, additional, Rodrigues, Jonathan, additional, Rofe, Chris, additional, Schofield, Rebecca, additional, Semple, Thomas, additional, Sheikh, Azeem, additional, Sinha, Apurva, additional, Subedi, Deepak, additional, Topping, William, additional, Tweed, Katherine, additional, Underwood, Stephen Richard, additional, Weir-Mccall, Jonathan, additional, Zuhairy, Hamed, additional, Abbasi, Taimur, additional, Abohashem, Shady, additional, Abramson, Sandra, additional, Al-Mallah, Mouaz, additional, Kumar, Mohan Ashok, additional, Balmer-Swain, Mallory, additional, Berman, Daniel, additional, Bernheim, Adam, additional, Bhatti, Sabha, additional, Biederman, Robert, additional, Bieging, Erik, additional, Bingham, Scott, additional, Bloom, Stephen, additional, Blue, Sean, additional, Borges, Andressa, additional, Branch, Kelley, additional, Bravo, Paco, additional, Buddhe, Sujatha, additional, Budoff, Matthew, additional, Bullock-Palmer, Renée, additional, Cahill, Michael, additional, Candela, Candace, additional, Cao, Jane, additional, Chatterjee, Saurav, additional, Chatzizisis, Yiannis, additional, Chaudhuri, Nita Ray, additional, Cheezum, Michael, additional, Chelliah, Anjali, additional, Chen, Tiffany, additional, Chen, Marcus, additional, Chen, Lu, additional, Chokshi, Aalap, additional, Chung, Jina, additional, Danciu, Sorin, additional, DeSisto, William, additional, Dilorenzo, Michael, additional, Doukky, Rami, additional, Duvall, William, additional, Ferencik, Maros, additional, Foster, Cameron, additional, Fuisz, Anthon, additional, Gannon, Michael, additional, German, David, additional, Gerson, Myron, additional, Geske, Jeffrey, additional, Hage, Fadi, additional, Haider, Agha, additional, Haider, Sofia, additional, Hamirani, Yasmin, additional, Hassen, Karen, additional, Hendel, Robert, additional, Henkel, Jacqueline, additional, Horgan, Stephen, additional, Hyun, Mark, additional, Janardhanan, Rajesh, additional, Jerome, Scott, additional, Kalra, Dinesh, additional, Kassop, David, additional, Kinkhabwala, Mona, additional, Kinzfogl, George, additional, Koch, Bernard, additional, Koweek, Lynne, additional, Krepp, Joseph, additional, Kwon, Younghoon, additional, Layer, Jay, additional, Lesser, John, additional, Leung, Steve, additional, Lisske, Bernadette, additional, Magurany, Kathleen, additional, Markowitz, Jeremy, additional, Mccullough, Brenda, additional, Moalemi, Azita, additional, Moffitt, Chanan, additional, Montanez, Juan, additional, Moore, Warren, additional, Morayati, Shamil, additional, Mossa-Basha, Mahmud, additional, Mrsic, Zorana, additional, Murthy, Venkatesh, additional, Nagpal, Prashant, additional, Nelson, Katarina, additional, Nijjar, Prabhjot, additional, O’Quinn, Rupal, additional, Passen, Edward, additional, Patel, Toral, additional, Patil, Pravin, additional, Pursnani, Amit, additional, Quachang, Nancy, additional, Rabbat, Mark, additional, Ranjan, Pragya, additional, Lozano, Patricia Rodriguez, additional, Schemmer, Mary, additional, Seifried, Rebecca, additional, Shah, Nishant, additional, Shah, Amee, additional, Shanbhag, Sujata, additional, Sharma, Gaurav, additional, Skotnicki, Robert, additional, Sobczak, Michael, additional, Soman, Prem, additional, Sorrell, Vincent, additional, Srichai, Monvadi, additional, Streeter, Jim, additional, Strickland, Leah, additional, Suliman, Suliman, additional, Tebyanian, Naghmeh, additional, Thomas, Dustin, additional, Thompson, Randall, additional, Uretsky, Seth, additional, Vallurupalli, Srikanth, additional, Vandyck-Acquah, Marian, additional, Verma, Vikas, additional, Villines, Todd, additional, Weinstein, Joseph, additional, Wolinsky, David, additional, Zareba, Karolina, additional, Zgaljardic, Michael, additional, Beretta, Mario, additional, Ferrando, Rodolfo, additional, Kapitan, Miguel, additional, Mut, Fernando, additional, Djuraev, Omoa, additional, Rozikhodjaeva, Gulnora, additional, Vera, Luisa, additional, Duc, Binh Duong, additional, Nguyen, Xuan Canh, additional, and Hiep Nguyen, Phuoc Minh, additional
- Published
- 2022
- Full Text
- View/download PDF
47. Preoperative [11C]methionine PET to personalize treatment decisions in patients with lower-grade gliomas
- Author
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Ninatti, Gaia, primary, Sollini, Martina, additional, Bono, Beatrice, additional, Gozzi, Noemi, additional, Fedorov, Daniil, additional, Antunovic, Lidija, additional, Gelardi, Fabrizia, additional, Navarria, Pierina, additional, Politi, Letterio S, additional, Pessina, Federico, additional, and Chiti, Arturo, additional
- Published
- 2022
- Full Text
- View/download PDF
48. Molecular imaging targeting carbonic anhydrase 9 in clear-cell renal cell carcinoma: more than meets the eye.
- Author
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Larcher, Alessandro, Gelardi, Fabrizia, Montorsi, Francesco, Capitanio, Umberto, and Chiti, Arturo
- Subjects
- *
RENAL cell carcinoma , *CARBONIC anhydrase - Published
- 2025
- Full Text
- View/download PDF
49. Patients’ findings after COVID-19 infection and vaccinations: what to expect from [18F]FDG PET/CT
- Author
-
Sollini, Martina, primary, Gelardi, Fabrizia, additional, Biroli, Matteo, additional, and Chiti, Arturo, additional
- Published
- 2021
- Full Text
- View/download PDF
50. State-of-the-art of FAPI-PET Imaging: A Systematic Review and Meta-Analysis
- Author
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Sollini, Martina, primary, Kirienko, Margarita, additional, Gelardi, Fabrizia, additional, Fiz, Francesco, additional, Gozzi, Noemi, additional, and Chiti, Arturo, additional
- Published
- 2021
- Full Text
- View/download PDF
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