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2. Kamerasensorik

Author

Punke, Martin, Werthessen, Boris, Geisler, Peter, Mindescu, Christian, Wagner, Andreas, Winner, Hermann, editor, Dietmayer, Klaus C J, editor, Eckstein, Lutz, editor, Jipp, Meike, editor, Maurer, Markus, editor, and Stiller, Christoph, editor

Published
2024
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3. Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Author

Ollila, Hanna M, Sharon, Eilon, Lin, Ling, Sinnott-Armstrong, Nasa, Ambati, Aditya, Yogeshwar, Selina M, Hillary, Ryan P, Jolanki, Otto, Faraco, Juliette, Einen, Mali, Luo, Guo, Zhang, Jing, Han, Fang, Yan, Han, Dong, Xiao Song, Li, Jing, Zhang, Jun, Hong, Seung-Chul, Kim, Tae Won, Dauvilliers, Yves, Barateau, Lucie, Lammers, Gert Jan, Fronczek, Rolf, Mayer, Geert, Santamaria, Joan, Arnulf, Isabelle, Knudsen-Heier, Stine, Bredahl, May Kristin Lyamouri, Thorsby, Per Medbøe, Plazzi, Giuseppe, Pizza, Fabio, Moresco, Monica, Crowe, Catherine, Van den Eeden, Stephen K, Lecendreux, Michel, Bourgin, Patrice, Kanbayashi, Takashi, Martínez-Orozco, Francisco J, Peraita-Adrados, Rosa, Benetó, Antonio, Montplaisir, Jacques, Desautels, Alex, Huang, Yu-Shu, Jennum, Poul, Nevsimalova, Sona, Kemlink, David, Iranzo, Alex, Overeem, Sebastiaan, Wierzbicka, Aleksandra, Geisler, Peter, Sonka, Karel, Honda, Makoto, Högl, Birgit, Stefani, Ambra, Coelho, Fernando Morgadinho, Mantovani, Vilma, Feketeova, Eva, Wadelius, Mia, Eriksson, Niclas, Smedje, Hans, Hallberg, Pär, Hesla, Per Egil, Rye, David, Pelin, Zerrin, Ferini-Strambi, Luigi, Bassetti, Claudio L, Mathis, Johannes, Khatami, Ramin, Aran, Adi, Nampoothiri, Sheela, Olsson, Tomas, Kockum, Ingrid, Partinen, Markku, Perola, Markus, Kornum, Birgitte R, Rueger, Sina, Winkelmann, Juliane, Miyagawa, Taku, Toyoda, Hiromi, Khor, Seik-Soon, Shimada, Mihoko, Tokunaga, Katsushi, Rivas, Manuel, Pritchard, Jonathan K, Risch, Neil, Kutalik, Zoltan, O’Hara, Ruth, Hallmayer, Joachim, Ye, Chun Jimmie, and Mignot, Emmanuel J

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Biological Sciences, Prevention, Vaccine Related, Influenza, Autoimmune Disease, Immunization, Pneumonia & Influenza, Emerging Infectious Diseases, Infectious Diseases, 2.1 Biological and endogenous factors, Aetiology, Infection, Inflammatory and immune system, Good Health and Well Being, Humans, Autoimmunity, Influenza, Human, Influenza A Virus, H1N1 Subtype, Autoimmune Diseases, Influenza Vaccines, Narcolepsy, FinnGen
Abstract

Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix®. Here, we dissect disease mechanisms and interactions with environmental triggers in a multi-ethnic sample of 6,073 cases and 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB1*03:01 and DPB1*04:02) and discovered seven novel associations (CD207, NAB1, IKZF4-ERBB3, CTSC, DENND1B, SIRPG, PRF1). Significant signals at TRA and DQB1*06:02 loci were found in 245 vaccination-related cases, who also shared polygenic risk. T cell receptor associations in NT1 modulated TRAJ*24, TRAJ*28 and TRBV*4-2 chain-usage. Partitioned heritability and immune cell enrichment analyses found genetic signals to be driven by dendritic and helper T cells. Lastly comorbidity analysis using data from FinnGen, suggests shared effects between NT1 and other autoimmune diseases. NT1 genetic variants shape autoimmunity and response to environmental triggers, including influenza A infection and immunization with Pandemrix®.

Published
2023

6. Transmission of plasmons through a nanowire

Author

Geisler, Peter, Krauss, Enno, Razinskas, Gary, and Hecht, Bert

Subjects
Physics - Optics
Abstract

Exact quantitative understanding of plasmon propagation along nanowires is mandatory for designing and creating functional devices. Here we investigate plasmon transmission through top-down fabricated monocrystalline gold nanowires on a glass substrate. We show that the transmission through finite-length nanowires can be described by Fabry-P\'{e}rot oscillations that beat with free-space propagating light launched at the incoupling end. Using an extended Fabry-P\'{e}rot model, experimental and simulated length dependent transmission signals agree quantitatively with a fully analytical model., Comment: 5 pages, 4 figures

Published
2017
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12. Multimode plasmon excitation and in-situ analysis in top-down fabricated plasmonic nanocircuits

Author

Geisler, Peter, Razinskas, Gary, Krauss, Enno, Wu, Xiao-Fei, Rewitz, Christian, Tuchscherer, Philip, Goetz, Sebastian, Huang, Chen-Bin, Brixner, Tobias, and Hecht, Bert

Subjects
Physics - Optics
Abstract

We experimentally demonstrate synthesis and in-situ analysis of multimode plasmonic excitations in two-wire transmission lines supporting a symmetric and an antisymmetric eigenmode. To this end we irradiate an incoupling antenna with a diffraction-limited excitation spot exploiting a polarization- and position-dependent excitation efficiency. Modal analysis is performed by recording the far-field emission of two mode-specific spatially separated emission spots at the far end of the transmission line. To illustrate the power of the approach we selectively determine the group velocities of symmetric and antisymmetric contributions of a multimode ultrafast plasmon pulse.

Published
2013
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14. Atomically flat single-crystalline gold nanostructures for plasmonic nanocircuitry

Author

Huang, Jer-Shing, Callegari, Victor, Geisler, Peter, Brüning, Christoph, Kern, Johannes, Prangsma, Jord C., Wu, Xiaofei, Feichtner, Thorsten, Ziegler, Johannes, Weinmann, Pia, Kamp, Martin, Forchel, Alfred, Biagioni, Paolo, Sennhauser, Urs, and Hecht, Bert

Subjects
Physics - Optics, Condensed Matter - Materials Science, Quantum Physics
Abstract

Deep subwavelength integration of high-definition plasmonic nanostructures is of key importance for the development of future optical nanocircuitry for high-speed communication, quantum computation and lab-on-a-chip applications. So far the experimental realization of proposed extended plasmonic networks consisting of multiple functional elements remains challenging, mainly due to the multi-crystallinity of commonly used thermally evaporated gold layers. Resulting structural imperfections in individual circuit elements will drastically reduce the yield of functional integrated nanocircuits. Here we demonstrate the use of very large (>100 micron^2) but thin (<80 nm) chemically grown single-crystalline gold flakes, which, after immobilization, serve as an ideal basis for focused-ion beam milling and other top-down nanofabrication techniques on any desired substrate. Using this methodology we obtain high-definition ultrasmooth gold nanostructures with superior optical properties and reproducible nano-sized features over micrometer length scales. Our approach provides a possible solution to overcome the current fabrication bottleneck and to realize high-definition plasmonic nanocircuitry., Comment: 28 pages, 14 figures, including Supporting Information (11 pages, 10 figures)

Published
2010
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15. Mode imaging and selection in strongly coupled nanoantennas

Author

Huang, Jer-Shing, Kern, Johannes, Geisler, Peter, Weinmann, Pia, Kamp, Martin, Forchel, Alfred, Biagioni, Paolo, and Hecht, Bert

Subjects
Physics - Optics, Physics - Plasma Physics
Abstract

The number of eigenmodes in plasmonic nanostructures increases with complexity due to mode hybridization, raising the need for efficient mode characterization and selection. Here we experimentally demonstrate direct imaging and selective excitation of the bonding and antibonding plasmon mode in symmetric dipole nanoantennas using confocal two-photon photoluminescence mapping. Excitation of a high-quality-factor antibonding resonance manifests itself as a two-lobed pattern instead of the single spot observed for the broad bonding resonance, in accordance with numerical simulations. The two-lobed pattern is observed due to the fact that excitation of the antibonding mode is forbidden for symmetric excitation at the feedgap, while concomitantly the mode energy splitting is large enough to suppress excitation of the bonding mode. The controlled excitation of modes in strongly coupled plasmonic nanostructures is mandatory for efficient sensors, in coherent control as well as for implementing well-defined functionalities in complex plasmonic devices., Comment: 11 pages, 5 figures, 1 supplementary information

Published
2010
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20. Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Author

Ollila, Hanna M., Sharon, Eilon, Lin, Ling, Sinnott-Armstrong, Nasa, Ambati, Aditya, Yogeshwar, Selina M., Hillary, Ryan P., Jolanki, Otto, Faraco, Juliette, Einen, Mali, Luo, Guo, Zhang, Jing, Han, Fang, Yan, Han, Dong, Xiao Song, Li, Jing, Zhang, Jun, Hong, Seung-Chul, Kim, Tae Won, Dauvilliers, Yves, Barateau, Lucie, Lammers, Gert Jan, Fronczek, Rolf, Mayer, Geert, Santamaria, Joan, Arnulf, Isabelle, Knudsen-Heier, Stine, Bredahl, May Kristin Lyamouri, Thorsby, Per Medboe, Plazzi, Giuseppe, Pizza, Fabio, Moresco, Monica, Crowe, Catherine, Van den Eeden, Stephen K., Lecendreux, Michel, Bourgin, Patrice, Kanbayashi, Takashi, Martinez-Orozco, Francisco J., Peraita-Adrados, Rosa, Beneto, Antonio, Montplaisir, Jacques, Desautels, Alex, Huang, Yu-Shu, FinnGen, Poul Jennum, Jennum, Poul, Nevsimalova, Sona, Kemlink, David, Iranzo, Alex, Overeem, Sebastiaan, Wierzbicka, Aleksandra, Geisler, Peter, Sonka, Karel, Honda, Makoto, Högl, Birgit, Stefani, Ambra, Coelho, Fernando Morgadinho, Mantovani, Vilma, Feketeova, Eva, Wadelius, Mia, Eriksson, Niclas, Smedje, Hans, Hallberg, Pär, Hesla, Per Egil, Rye, David, Pelin, Zerrin, Ferini-Strambi, Luigi, Bassetti, Claudio L., Mathis, Johannes, Khatami, Ramin, Aran, Adi, Nampoothiri, Sheela, Olsson, Tomas, Kockum, Ingrid, Partinen, Markku, Perola, Markus, Kornum, Birgitte R., Rueger, Sina, Winkelmann, Juliane, Miyagawa, Taku, Toyoda, Hiromi, Khor, Seik-Soon, Shimada, Mihoko, Tokunaga, Katsushi, Rivas, Manuel, Pritchard, Jonathan K., Risch, Neil, Kutalik, Zoltan, O'Hara, Ruth, Hallmayer, Joachim, Ye, Chun Jimmie, Mignot, Emmanuel J., Ollila, Hanna M., Sharon, Eilon, Lin, Ling, Sinnott-Armstrong, Nasa, Ambati, Aditya, Yogeshwar, Selina M., Hillary, Ryan P., Jolanki, Otto, Faraco, Juliette, Einen, Mali, Luo, Guo, Zhang, Jing, Han, Fang, Yan, Han, Dong, Xiao Song, Li, Jing, Zhang, Jun, Hong, Seung-Chul, Kim, Tae Won, Dauvilliers, Yves, Barateau, Lucie, Lammers, Gert Jan, Fronczek, Rolf, Mayer, Geert, Santamaria, Joan, Arnulf, Isabelle, Knudsen-Heier, Stine, Bredahl, May Kristin Lyamouri, Thorsby, Per Medboe, Plazzi, Giuseppe, Pizza, Fabio, Moresco, Monica, Crowe, Catherine, Van den Eeden, Stephen K., Lecendreux, Michel, Bourgin, Patrice, Kanbayashi, Takashi, Martinez-Orozco, Francisco J., Peraita-Adrados, Rosa, Beneto, Antonio, Montplaisir, Jacques, Desautels, Alex, Huang, Yu-Shu, FinnGen, Poul Jennum, Jennum, Poul, Nevsimalova, Sona, Kemlink, David, Iranzo, Alex, Overeem, Sebastiaan, Wierzbicka, Aleksandra, Geisler, Peter, Sonka, Karel, Honda, Makoto, Högl, Birgit, Stefani, Ambra, Coelho, Fernando Morgadinho, Mantovani, Vilma, Feketeova, Eva, Wadelius, Mia, Eriksson, Niclas, Smedje, Hans, Hallberg, Pär, Hesla, Per Egil, Rye, David, Pelin, Zerrin, Ferini-Strambi, Luigi, Bassetti, Claudio L., Mathis, Johannes, Khatami, Ramin, Aran, Adi, Nampoothiri, Sheela, Olsson, Tomas, Kockum, Ingrid, Partinen, Markku, Perola, Markus, Kornum, Birgitte R., Rueger, Sina, Winkelmann, Juliane, Miyagawa, Taku, Toyoda, Hiromi, Khor, Seik-Soon, Shimada, Mihoko, Tokunaga, Katsushi, Rivas, Manuel, Pritchard, Jonathan K., Risch, Neil, Kutalik, Zoltan, O'Hara, Ruth, Hallmayer, Joachim, Ye, Chun Jimmie, and Mignot, Emmanuel J.

Abstract

Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix (R). Here, we dissect disease mechanisms and interactions with environmental triggers in a multi-ethnic sample of 6,073 cases and 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB1*03:01 and DPB1*04:02) and discovered seven novel associations (CD207, NAB1, IKZF4-ERBB3, CTSC, DENND1B, SIRPG, PRF1). Significant signals at TRA and DQB1*06:02 loci were found in 245 vaccination-related cases, who also shared polygenic risk. T cell receptor associations in NT1 modulated TRAJ*24, TRAJ*28 and TRBV*4-2 chain-usage. Partitioned heritability and immune cell enrichment analyses found genetic signals to be driven by dendritic and helper T cells. Lastly comorbidity analysis using data from FinnGen, suggests shared effects between NT1 and other autoimmune diseases. NT1 genetic variants shape autoimmunity and response to environmental triggers, including influenza A infection and immunization with Pandemrix (R).

Published
2023
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22. Tinnitus and Sleep

Author

Crönlein, Tatjana, Geisler, Peter, Hajak, Göran, Møller, Aage R., editor, Langguth, Berthold, editor, De Ridder, Dirk, editor, and Kleinjung, Tobias, editor

Published
2011
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24. Durchführung und Interpretation des multiplen Schlaflatenztests (MSLT) bei Erwachsenen

Author

Veauthier, Christian, Kallweit, Ulf, Schulz, Hartmut, Mathis, Johannes, Geisler, Peter, Zaremba, Sebastian, de Almeida Schreck, Renata N. B., Hillberg, Andrea, Todorova-Rudolph, Anelia, Brandt, Moritz, Heidbreder, Anna, and Mayer, Geert

Abstract

Der multiple Schlaflatenztest (MSLT) ist ein diagnostisches Instrument zur objektiven Bestimmung der Einschlafneigung am Tage. Er dient der Differentialdiagnostik der Narkolepsie, Hypersomnie und anderen Erkrankungen mit gesteigerter Tagesschläfrigkeit. Mittels Elektroenzephalographie, Elektromyographie des Kinns und Elektrookulographie werden in diesem Einschlaftest die durchschnittliche Einschlaflatenz sowie das Auftreten von REM-Schlaf, unter idealen Schlafbedingungen in einem abgedunkelten Raum mit der Aufforderung einzuschlafen, gemessen. Er wird tagsüber nach einer Polysomnographie in der vorausgehenden Nacht durchgeführt und besteht aus fünf standardisierten Testdurchgängen im Abstand von jeweils zwei Stunden. Medikamente, Schlafentzug sowie stimulierende Substanzen oder Aktivitäten können die Ergebnisse des Tests beeinflussen. Im Jahr 2021 wurde die MSLT-Leitlinie seitens der American Academy of Sleep Medicine (AASM) aktualisiert. Der vorliegende Artikel stellt die aktualisierte Richtlinie vor und kommentiert diese.

Published
2024
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31. The European Narcolepsy Network (EU-NN) database

Author

Khatami, Ramin, Luca, Gianina, Baumann, Christian R., Bassetti, Claudio L., Bruni, Oliviero, Canellas, Francesca, Dauvilliers, Yves, Del Rio-Villegas, Rafael, Feketeova, Eva, Ferri, Raffaele, Geisler, Peter, Högl, Birgit, Jennum, Poul, Kornum, Birgitte R., Lecendreux, Michel, Martins-da-Silva, Antonio, Mathis, Johannes, Mayer, Geert, Paiva, Teresa, Partinen, Markku, Peraita-Adrados, Rosa, Plazzi, Guiseppe, Santamaria, Joan, Sonka, Karel, Riha, Renata, Tafti, Mehdi, Wierzbicka, Aleksandra, Young, Peter, Lammers, Gert Jan, and Overeem, Sebastiaan

Published
2016
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38. Narcolepsy-Associated HLA Class I Alleles Implicate Cell-Mediated Cytotoxicity

Author

Tafti, Mehdi, Lammers, Gert J., Dauvilliers, Yves, Overeem, Sebastiaan, Mayer, Geert, Nowak, Jacek, Pfister, Corinne, Dubois, Valérie, Eliaou, Jean-François, Eberhard, Hans-Peter, Liblau, Roland, Wierzbicka, Aleksandra, Geisler, Peter, Bassetti, Claudio L., Mathis, Johannes, Lecendreux, Michel, Khatami, Ramin, Heinzer, Raphaël, Haba-Rubio, José, Feketeova, Eva, Baumann, Christian R., Kutalik, Zoltán, Tiercy, Jean-Marie, Tafti, Mehdi, Lammers, Gert J., Dauvilliers, Yves, Overeem, Sebastiaan, Mayer, Geert, Nowak, Jacek, Pfister, Corinne, Dubois, Valérie, Eliaou, Jean-François, Eberhard, Hans-Peter, Liblau, Roland, Wierzbicka, Aleksandra, Geisler, Peter, Bassetti, Claudio L., Mathis, Johannes, Lecendreux, Michel, Khatami, Ramin, Heinzer, Raphaël, Haba-Rubio, José, Feketeova, Eva, Baumann, Christian R., Kutalik, Zoltán, and Tiercy, Jean-Marie

Abstract

Study Objectives: Narcolepsy with cataplexy is tightly associated with the HLA class II allele DQB1*06:02. Evidence indicates a complex contribution of HLA class II genes to narcolepsy susceptibility with a recent independent association with HLA-DPB1. The cause of narcolepsy is supposed be an autoimmune attack against hypocretin-producing neurons. Despite the strong association with HLA class II, there is no evidence for CD4+ T-cell-mediated mechanism in narcolepsy. Since neurons express class I and not class II molecules, the final effector immune cells involved might include class I-restricted CD8+ T-cells. Methods: HLA class I (A, B, and C) and II (DQB1) genotypes were analyzed in 944 European narcolepsy with cataplexy patients and in 4,043 control subjects matched by country of origin. All patients and controls were DQB1*06:02 positive and class I associations were conditioned on DQB1 alleles. Results: HLA-A*11:01 (OR = 1.49 [1.18-1.87] P = 7.0*10−4), C*04:01 (OR = 1.34 [1.10-1.63] P = 3.23*10−3), and B*35:01 (OR = 1.46 [1.13-1.89] P = 3.64*10−3) were associated with susceptibility to narcolepsy. Analysis of polymorphic class I amino-acids revealed even stronger associations with key antigen-binding residues HLA-A-Tyr9 (OR = 1.32 [1.15-1.52] P = 6.95*10−5) and HLA-C-Ser11 (OR = 1.34 [1.15-1.57] P = 2.43*10−4). Conclusions: Our findings provide a genetic basis for increased susceptibility to infectious factors or an immune cytotoxic mechanism in narcolepsy, potentially targeting hypocretin neurons. Significance Although evidence strongly indicates that immune-related mechanisms are involved in the pathogenesis of narcolepsy with hypocretin deficiency, functional data are missing. The strong association with HLA class II genes is not corroborated by any CD4+ T Cell implication and inflammation. Additionally, these genes are not normally expressed in the brain. Here, we show that several HLA class I variants are associated with narcolepsy. Since these mol

Published
2021

43. Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study

Author

Luca, Gianina, Haba-Rubio, José, Dauvilliers, Yves, Lammers, Gert-Jan, Overeem, Sebastiaan, Donjacour, Claire E., Mayer, Geert, Javidi, Sirous, Iranzo, Alex, Santamaria, Joan, Peraita-Adrados, Rosa, Hor, Hyun, Kutalik, Zoltan, Plazzi, Giuseppe, Poli, Francesca, Pizza, Fabio, Arnulf, Isabelle, Lecendreux, Michel, Bassetti, Claudio, Mathis, Johannes, Heinzer, Raphael, Jennum, Poul, Knudsen, Stine, Geisler, Peter, Wierzbicka, Aleksandra, Feketeova, Eva, Pfister, Corinne, Khatami, Ramin, Baumann, Christian, and Tafti, Mehdi

Published
2013
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44. Narcolepsy and pregnancy: a retrospective European evaluation of 249 pregnancies

Author

Maurovich-Horvat, Eszter, Kemlink, David, Högl, Birgit, Frauscher, Birgit, Ehrmann, Laura, Geisler, Peter, Ettenhuber, Katharina, Mayer, Geert, Peraita-Adrados, Rosa, Calvo, Elena, Lammers, Gert Jan, Van der Heide, Astrid, Ferini-Strambi, Luigi, Plazzi, Giuseppe, Poli, Francesca, Dauvilliers, Yves, Jennum, Poul, Leonthin, Helle, Mathis, Johannes, Wierzbicka, Aleksandra, Puertas, Francisco J., Beitinger, Pierre A., Arnulf, Isabelle, Riha, Renata L., Tormášiová, Maria, Slonková, Jana, Nevšímalová, Sona, and Šonka, Karel

Published
2013
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47. Treatment of moderate to severe restless legs syndrome: 2-year safety and efficacy of rotigotine transdermal patch

Author

Trenkwalder Claudia, García-Borreguero Diego, Beneš Heike, Geisler Peter, Stiasny-Kolster Karin, Oertel Wolfgang H, Högl Birgit, Poewe Werner, Schollmayer Erwin, and Kohnen Ralf

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Rotigotine is a unique dopamine agonist with activity across D1 through D5 receptors as well as select adrenergic and serotonergic sites. This study reports the 2-year follow-up safety and efficacy data of an ongoing open-label multicenter extension study (NCT00498186) of transdermal rotigotine in patients with moderate to severe restless legs syndrome (RLS). Methods Patients received a once-daily patch application of an individually optimized dose of rotigotine between 0.5 mg/24 h to 4 mg/24 h. Safety assessments included adverse events (AEs) and efficacy was measured by the International RLS Study Group Severity Rating Scale (IRLS), RLS-6 scales and Clinical Global Impression (CGI). Quality of life (QoL) was measured by QoL-RLS. Results Of 310 patients who completed a 6-week placebo-controlled trial (SP709), 295 (mean age 58 ± 10 years, 66% females) were included in the open-label trial SP710. 64.7% (190/295 patients) completed the 2-year follow-up; 29 patients discontinued during the second year. Mean daily rotigotine dose after 2 years was 2.93 ± 1.14 mg/24 h with a 2.9% dose increase from year 1. Rotigotine was generally well tolerated. The rate of typical dopaminergic side effects, nausea and fatigue, was low (0.9% and 2.3%, respectively) during the second year; application site reactions were frequent but lower than in year 1 (16.4% vs. 34.5%). The IRLS total score improved from baseline of SP709 (27.8 ± 5.9) by 17.2 ± 9.2 in year 2 completers. Similar improvements were observed in RLS-6 scales, CGI scores and QoL-RLS. The responder rate in the CGI change item 2 ("much" and "very much" improved) was 95% after year 2. Conclusions Transdermal rotigotine is an efficacious and well-tolerated long-term treatment option for patients with moderate to severe RLS with a high retention rate during 2 years of therapy. Trial registration NCT00498186

Published
2010
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50. Narcolepsy risk loci are enriched in immune cells and suggest autoimmune modulation of the T cell receptor repertoire

Author

Ollila, Hanna M, primary, Sharon, Eilon, additional, Lin, Ling, additional, Sinnott-Armstrong, Nasa, additional, Ambati, Aditya, additional, Hillary, Ryan P, additional, Jolanki, Otto, additional, Faraco, Juliette, additional, Einen, Mali, additional, Luo, Guo, additional, Zhang, Jing, additional, Han, Fang, additional, Yan, Han, additional, Dong, Xiao Song, additional, Li, Jing, additional, Zhang, Jun, additional, Hong, Seung-Chul, additional, Kim, Tae Won, additional, Dauvilliers, Yves, additional, Barateau, Lucie, additional, Lammers, Gert Jan, additional, Fronczek, Rolf, additional, Mayer, Geert, additional, Santamaria, Joan, additional, Arnulf, Isabelle, additional, Knudsen, Stine, additional, Bredahl, May Kristin Lyamouri, additional, Thorsby, Per Medbøe, additional, Plazzi, Giuseppe, additional, Pizza, Fabio, additional, Moresco, Monica, additional, Crowe, Catherine, additional, Van den Eeden, Stephen K, additional, Lecendreux, Michel, additional, Bourgin, Patrice, additional, Kanbayashi, Takashi, additional, Peraita-Adrados, Rosa, additional, Martínez-Orozco, Francisco J, additional, Benetó, Antonio, additional, Montplaisir, Jacques, additional, Desautels, Alex, additional, Huang, Yu-Shu, additional, Jennum, Poul, additional, Nevsimalova, Sona, additional, Kemlink, David, additional, Iranzo, Alex, additional, Overeem, Sebastian, additional, Wierzbicka, Aleksandra, additional, Geisler, Peter, additional, Sonka, Karel, additional, Honda, Makoto, additional, Högl, Birgit, additional, Stefani, Ambra, additional, Coelho, Fernando Morgadinho, additional, Mantovani, Vilma, additional, Feketeova, Eva, additional, Wadelius, Mia, additional, Eriksson, Niclas, additional, Smedje, Hans, additional, Hallberg, Pär, additional, Hesla, Per Egil, additional, Rye, David, additional, Pelin, Zerrin, additional, Ferini-Strambi, Luigi, additional, Bassetti, Claudio L, additional, Mathis, Johannes, additional, Khatami, Ramin, additional, Aran, Adi, additional, Nampoothiri, Sheela, additional, Olsson, Tomas, additional, Kockum, Ingrid, additional, Partinen, Markku, additional, Perola, Markus, additional, Kornum, Birgitte R, additional, Rueger, Sina, additional, Winkelmann, Juliane, additional, Miyagawa, Taku, additional, Toyoda, Hiromi, additional, Khor, Seik Soon, additional, Shimada, Mihoko, additional, Tokunaga, Katsushi, additional, Rivas, Manuel, additional, Pritchard, Jonathan K, additional, Risch, Neil, additional, Kutalik, Zoltan, additional, O’Hara, Ruth, additional, Hallmayer, Joachim, additional, Ye, Chun Jimmie, additional, and Mignot, Emmanuel, additional

Published
2018
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