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389 results on '"Geisel, Jürgen"'

3. Circulating pyridoxal 5′-phosphate in serum and whole blood: implications for assessment of vitamin B6 status

Author

Obeid Rima, Möller Christoph, and Geisel Jürgen

Subjects
cystathionine, deficiency, homocysteine, pyridoxal 5′-phosphate, thiamine pyrophosphate, vitamin b6, Medical technology, R855-855.5
Abstract

Concentrations of pyridoxal 5′-phosphate (PLP) in serum and whole blood are routinely measured. The suitability of these markers in capturing vitamin B6 insufficiency is not well studied.

Published
2023
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4. TNF-related apoptosis-inducing ligand, interferon gamma-induced protein 10, and C-reactive protein in predicting the progression of SARS-CoV-2 infection: a prospective cohort study

Author

Tegethoff, Sina A., Danziger, Guy, Kühn, Dennis, Kimmer, Charlotte, Adams, Thomas, Heintz, Lena, Metz, Carlos, Reifenrath, Katharina, Angresius, Rebecca, Mang, Sebastian, Rixecker, Torben, Becker, André, Geisel, Jürgen, Jentgen, Christophe, Seiler, Frederik, Reichert, Matthias C., Fröhlich, Franziska, Meyer, Sascha, Rissland, Jürgen, Ewen, Sebastian, Wagenpfeil, Gudrun, Last, Katharina, Smola, Sigrun, Bals, Robert, Lammert, Frank, Becker, Sören L., Krawczyk, Marcin, Lepper, Philipp M., and Papan, Cihan

Published
2022
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7. German federal-state-wide seroprevalence study of 1st SARS-CoV-2 pandemic wave shows importance of long-term antibody test performance

Author

Lohse, Stefan, Sternjakob-Marthaler, Anna, Lagemann, Paul, Schöpe, Jakob, Rissland, Jürgen, Seiwert, Nastasja, Pfuhl, Thorsten, Müllendorff, Alana, Kiefer, Laurent S., Vogelgesang, Markus, Vella, Luca, Denk, Katharina, Vicari, Julia, Zwick, Anabel, Lang, Isabelle, Weber, Gero, Geisel, Jürgen, Rech, Jörg, Schnabel, Bernd, Hauptmann, Gunter, Holleczek, Bernd, Scheiblauer, Heinrich, Wagenpfeil, Stefan, and Smola, Sigrun

Published
2022
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11. Neutrophil extracellular trap biomarkers in aneurysmal subarachnoid hemorrhage: early decline of DNase 1 activity associated with delayed cerebral ischemia.

Author

Hendrix, Philipp, Witsch, Jens, Spalart, Valérie, Schneider, Hauke, Oertel, Joachim, Geisel, Jürgen, Martinod, Kimberly, and Hemmer, Sina

Subjects
CEREBRAL ischemia, SUBARACHNOID hemorrhage, CEREBRAL infarction, NEUTROPHILS, CELL-free DNA
Abstract

Introduction: High-mobility group box 1 (HMGB1) protein is a critical mediator of neutrophil extracellular trap (NET) formation (NETosis). Myeloperoxidase (MPO)- DNA complexes, a biomarker of NETs, and HMGB1 have been associated with delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). Additional mechanistic NET-related biomarkers and their role in the neuroinflammatory cascade surrounding DCI remain to be explored. Methods: A post-hoc analysis of a prospective, blinded, single-center biomarker observational study was performed. De novo measurements of serum citrullinated histone H3-DNA complexes (H3Cit-DNA), peptidylarginine deiminase 4 (PAD4), cell-free DNA (cf-DNA), and DNase 1 activity were conducted on admission (D0) and day 4 (D4). Delayed cerebral infarction (DCI) was defined as new cerebral infarction on CT head not present on the post-treatment scan. Results: H3Cit-DNA, PAD4, cf-DNA, and DNase 1 activity were within quantifiable ranges in all serum samples analyzed at D0 and D4. Admission biomarker levels were not associated with DCI development. From D0 to D4, in both the DCI and the non-DCI groups, H3Cit-DNA levels significantly decreased, cf-DNA levels significantly increased, and PAD4 levels remained stable. In contrast, DNase 1 activity significantly decreased from D0 to D4 in the DCI group (p < 0.001) but not in the non-DCI group. Conclusion: This exploratory analysis demonstrated NET-related biomarkers such as H3Cit-DNA, PAD4, cf-DNA, and DNase 1 activity in all aSAH patients. A decline of systemic DNase 1 activity in the early phase might increase the risk of delayed cerebral ischemia. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Antibiotic therapeutic drug monitoring in intensive care patients treated with different modalities of extracorporeal membrane oxygenation (ECMO) and renal replacement therapy: a prospective, observational single-center study

Author

Kühn, Dennis, Metz, Carlos, Seiler, Frederik, Wehrfritz, Holger, Roth, Sophie, Alqudrah, Mohammad, Becker, André, Bracht, Hendrik, Wagenpfeil, Stefan, Hoffmann, Mathias, Bals, Robert, Hübner, Ulrich, Geisel, Jürgen, Lepper, Philipp M., and Becker, Sören L.

Published
2020
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32. Abnormal High-Density Lipoprotein Induces Endothelial Dysfunction via Activation of Toll-like Receptor-2

Author

Speer, Thimoteus, Rohrer, Lucia, Blyszczuk, Przemyslaw, Shroff, Rukshana, Kuschnerus, Kira, Kränkel, Nicolle, Kania, Gabriela, Zewinger, Stephen, Akhmedov, Alexander, Shi, Yi, Martin, Tina, Perisa, Damir, Winnik, Stephan, Müller, Maja F., Sester, Urban, Wernicke, Gabriel, Jung, Andreas, Gutteck, Ursula, Eriksson, Urs, Geisel, Jürgen, Deanfield, John, von Eckardstein, Arnold, Lüscher, Thomas F., Fliser, Danilo, Bahlmann, Ferdinand H., and Landmesser, Ulf

Published
2013
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33. Die Assoziation von Myeloperoxidase-DNA-Komplexen und High Mobility Group Box 1 Protein mit verzögerter zerebraler Ischämie nach aneurysmatischer Subarachnoidalblutung

Author

Hendrix, Philipp, Witsch, Jens, Spalart, Valerie, Martinod, Kimberly, Schneider, Hauke, Oertel, Joachim, Geisel, Jürgen, and Hemmer, Sina

Subjects
ddc: 610, Medicine and health, chemical and pharmacologic phenomena, cardiovascular diseases
Abstract

Objective: High mobility group box 1 protein (HMGB1) acts as a key player in aseptic inflammation. Admission serum HMGB1 serves as an independent biomarker predictive of delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage (aSAH). Released by leucocytes and platelets, HMGB1 has been [for full text, please go to the a.m. URL]

Published
2022

36. Transient receptor potential channel vanilloid type 2 in red cells of cannabis consumer

Author

Flormann, Daniel, primary, Qiao, Min, additional, Murciano, Nicoletta, additional, Iacono, Giulia, additional, Darras, Alexis, additional, Hof, Sebastian, additional, Recktenwald, Steffen M., additional, Rotordam, Maria Giustina, additional, Becker, Nadine, additional, Geisel, Jürgen, additional, Wagner, Christian, additional, von Lindern, Marieke, additional, Akker, Emile, additional, and Kaestner, Lars, additional

Published
2022
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41. The Erythrocyte Sedimentation Rate and Its Relation to Cell Shape and Rigidity of Red Blood Cells from Chorea-Acanthocytosis Patients in an Off-Label Treatment with Dasatinib

Author

Rabe, Antonia, Kihm, Alexander, Darras, Alexis, Peikert, Kevin, Simionato, Greta, Dasanna, Anil Kumar, Glaß, Hannes, Geisel, Jürgen, Quint, Stephan, Danek, Adrian, Wagner, Christian, Fedosov, Dmitry A., Hermann, Andreas, and Kaestner, Lars

Subjects
Adult, Male, Erythrocytes, microfluidics, therapeutic use [Dasatinib], 3D shapes, Blood Sedimentation, drug effects [Acanthocytes], cell rigidity, Microbiology, Article, ddc:570, therapeutic use [Protein Kinase Inhibitors], Humans, dasatinib, acanthocytes, Cell Shape, Protein Kinase Inhibitors, drug effects [Cell Shape], blood [Biomarkers], drug therapy [Neuroacanthocytosis], Off-Label Use, QR1-502, pathology [Acanthocytes], phase diagram, mesoscopic modeling, drug effects [Blood Sedimentation], drug effects [Erythrocytes], erythrocyte sedimentation rate, blood [Neuroacanthocytosis], Biomarkers, Neuroacanthocytosis, pathology [Neuroacanthocytosis]
Abstract

Background: Chorea-acanthocytosis (ChAc) is a rare hereditary neurodegenerative disease with deformed red blood cells (RBCs), so-called acanthocytes, as a typical marker of the disease. Erythrocyte sedimentation rate (ESR) was recently proposed as a diagnostic biomarker. To date, there is no treatment option for affected patients, but promising therapy candidates, such as dasatinib, a Lyn-kinase inhibitor, have been identified. Methods: RBCs of two ChAc patients during and after dasatinib treatment were characterized by the ESR, clinical hematology parameters and the 3D shape classification in stasis based on an artificial neural network. Furthermore, mathematical modeling was performed to understand the contribution of cell morphology and cell rigidity to the ESR. Microfluidic measurements were used to compare the RBC rigidity between ChAc patients and healthy controls. Results: The mechano-morphological characterization of RBCs from two ChAc patients in an off-label treatment with dasatinib revealed differences in the ESR and the acanthocyte count during and after the treatment period, which could not directly be related to each other. Clinical hematology parameters were in the normal range. Mathematical modeling indicated that RBC rigidity is more important for delayed ESR than cell shape. Microfluidic experiments confirmed a higher rigidity in the normocytes of ChAc patients compared to healthy controls. Conclusions: The results increase our understanding of the role of acanthocytes and their associated properties in the ESR, but the data are too sparse to answer the question of whether the ESR is a suitable biomarker for treatment success, whereas a correlation between hematological and neuronal phenotype is still subject to verification.

Published
2021
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46. Additional file 1 of Combined antibiotic stewardship and infection control measures to contain the spread of linezolid-resistant Staphylococcus epidermidis in an intensive care unit

Author

Papan, Cihan, Schröder, Matthias, Hoffmann, Mathias, Knoll, Heike, Last, Katharina, Albrecht, Frederic, Geisel, Jürgen, Fink, Tobias, Gärtner, Barbara C., Mellmann, Alexander, Volk, Thomas, Berger, Fabian K., and Becker, Sören L.

Abstract

Additional file 1: Figure S1. Pocket card on the use of antibiotics with Gram-positive coverage, provided during the antimicrobial stewardship intervention on an intensive care unit in southwest Germany, 2018–2020.

Published
2021
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47. Additional file 3 of Combined antibiotic stewardship and infection control measures to contain the spread of linezolid-resistant Staphylococcus epidermidis in an intensive care unit

Author

Papan, Cihan, Schröder, Matthias, Hoffmann, Mathias, Knoll, Heike, Last, Katharina, Albrecht, Frederic, Geisel, Jürgen, Fink, Tobias, Gärtner, Barbara C., Mellmann, Alexander, Volk, Thomas, Berger, Fabian K., and Becker, Sören L.

Abstract

Additional file 3: Table S2. Expenses for the three antibiotics studied during the investigation of an outbreak by linezolid-resistant Staphylococcus epidermidis on an intensive care unit in Germany, for 2018 and 2019 each, and the calculated differences.

Published
2021
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49. Acanthocyte Sedimentation Rate as a Diagnostic Biomarker for Neuroacanthocytosis Syndromes: Experimental Evidence and Physical Justification.

Author

DFG [sponsor], Darras, Alexis, Peikert, Kevin, Rabe, Antonia, Yaya, François, Simionato, Greta, John, Thomas, Dasanna, Anil Kumar, Buvalyy, Semen, Geisel, Jürgen, Hermann, Andreas, Fedosov, Dmitry A., Danek, Adrian, Wagner, Christian, Kaestner, Lars, DFG [sponsor], Darras, Alexis, Peikert, Kevin, Rabe, Antonia, Yaya, François, Simionato, Greta, John, Thomas, Dasanna, Anil Kumar, Buvalyy, Semen, Geisel, Jürgen, Hermann, Andreas, Fedosov, Dmitry A., Danek, Adrian, Wagner, Christian, and Kaestner, Lars

Abstract

(1) Background: Chorea-acanthocytosis and McLeod syndrome are the core diseases among the group of rare neurodegenerative disorders called neuroacanthocytosis syndromes (NASs). NAS patients have a variable number of irregularly spiky erythrocytes, so-called acanthocytes. Their detection is a crucial but error-prone parameter in the diagnosis of NASs, often leading to misdiagnoses. (2) Methods: We measured the standard Westergren erythrocyte sedimentation rate (ESR) of various blood samples from NAS patients and healthy controls. Furthermore, we manipulated the ESR by swapping the erythrocytes and plasma of different individuals, as well as replacing plasma with dextran. These measurements were complemented by clinical laboratory data and single-cell adhesion force measurements. Additionally, we followed theoretical modeling approaches. (3) Results: We show that the acanthocyte sedimentation rate (ASR) with a two-hour read-out is significantly prolonged in chorea-acanthocytosis and McLeod syndrome without overlap compared to the ESR of the controls. Mechanistically, through modern colloidal physics, we show that acanthocyte aggregation and plasma fibrinogen levels slow down the sedimentation. Moreover, the inverse of ASR correlates with the number of acanthocytes (R2=0.61, p=0.004). (4) Conclusions: The ASR/ESR is a clear, robust and easily obtainable diagnostic marker. Independently of NASs, we also regard this study as a hallmark of the physical view of erythrocyte sedimentation by describing anticoagulated blood in stasis as a percolating gel, allowing the application of colloidal physics theory.

Published
2021
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50. Acanthocyte Sedimentation Rate as a Diagnostic Biomarker for Neuroacanthocytosis Syndromes: Experimental Evidence and Physical Justification

Author

Darras, Alexis, primary, Peikert, Kevin, additional, Rabe, Antonia, additional, Yaya, François, additional, Simionato, Greta, additional, John, Thomas, additional, Dasanna, Anil Kumar, additional, Buvalyy, Semen, additional, Geisel, Jürgen, additional, Hermann, Andreas, additional, Fedosov, Dmitry A., additional, Danek, Adrian, additional, Wagner, Christian, additional, and Kaestner, Lars, additional

Published
2021
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