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22. Mehrlingsreduktion

Author

Geipel, Annegret, Gembruch, Ulrich, Berg, Christoph, Diedrich, Klaus, editor, Ludwig, Michael, editor, and Griesinger, Georg, editor

Published
2020
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29. Prenatal diagnosis and outcome of fetal urinomas in relation to the underlying etiology.

Author

Simonini, Corinna, Strizek, Brigitte, Strömer, Annika, Gembruch, Ulrich, and Geipel, Annegret

Abstract

Objective: Evaluation of course and outcome of pregnancies with prenatally diagnosed fetal urinoma in a single center over a 20‐year period. Methods: Retrospective study including all prenatally suspected or diagnosed fetal urinomas. Cases were analyzed by ultrasound findings during pregnancy, comparing urinomas caused by lower urinary tract obstruction (LUTO) and ureteropelvic or ureterovesical junction obstruction (UPJO/UVJO). Course of pregnancy and outcomes were compared according to the underlying etiology. Results: 87 cases of fetal urinomas were identified between 2002 and 2022. The underlying etiology was LUTO in 56.3% and UPJO/UVJO in 43.7%. Complications mainly included oligo‐ or anhydramnios, thoracic hypoplasia as well as associated renal abnormalities. Postnatally, loss of function (LOF) in kidneys affected by urinomas was seen in 78.6% of children overall, but significantly more often in cases of UPJO/UVJO than in LUTO (86.2% vs. 70.2%, p < 0.05). Conclusion: Association of prenatal urinoma and postnatal LOF of the affected kidney is high, especially in cases caused by UPJO/UVJO. In survivors with urinoma caused by UPJO/UVJO, the general prognosis is excellent if the contralateral kidney was normal. In survivors with urinomas caused by LUTO, long‐term prognosis depends on postnatal renal and pulmonary function. Key points: What's already known about this topic? Urinomas are encapsulated accumulations of extravasated urine within the perirenal fascia. Antenatally, the main cause is urinary tract obstruction. Whether the presence of urinoma antenatally is a sign of a rescue mechanism to preserve fetal renal function or whether it is indicative of irreversible kidney damage has been discussed controversially in the past. What does this study add? Fetal urinomas are often associated with loss of function (LOF) of the affected kidney postnatally, especially in cases caused by ureteropelvic junction obstruction (UPJO) or ureterovesical junction obstruction (UVJO). Long‐term outcome in children with unilateral urinoma caused by UPJO/UVJO is usually excellent, given that the contralateral kidney function is normal. In urinomas associated with lower urinary tract obstruction (LUTO), long‐term outcome remains dependent on postnatal pulmonary and renal function. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Deep Learning Denoising Reconstruction for Improved Image Quality in Fetal Cardiac Cine MRI

Author

Vollbrecht, Thomas M, primary, Hart, Christopher, additional, Zhang, Shuo, additional, Katemann, Christoph, additional, Sprinkart, Alois M, additional, Isaak, Alexander, additional, Attenberger, Ulrike, additional, Pieper, Claus C, additional, Kütting, Daniel, additional, Geipel, Annegret, additional, Strizek, Brigitte, additional, and Luetkens, Julian A, additional

Published
2023
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41. Survival in very preterm infants with congenital diaphragmatic hernia and association with prenatal imaging markers: A retrospective cohort study

Author

Horn‐Oudshoorn, Emily J. J., primary, Russo, Francesca M., additional, Deprest, Jan A., additional, Kipfmueller, Florian, additional, Geipel, Annegret, additional, Schaible, Thomas, additional, Rafat, Neysan, additional, Cordier, Anne‐Gael, additional, Benachi, Alexandra, additional, Abbasi, Nimrah, additional, Chiu, Priscilla P. L., additional, de Boode, Willem P., additional, Sikkel, Esther, additional, Peters, Nina C. J., additional, Hansen, Bettina E., additional, Reiss, Irwin K. M., additional, and DeKoninck, Philip L. J., additional

Published
2023
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46. Fetal Cardiac Cine MRI with Doppler US Gating in Complex Congenital Heart Disease

Author

Vollbrecht, Thomas M., primary, Hart, Christopher, additional, Zhang, Shuo, additional, Katemann, Christoph, additional, Isaak, Alexander, additional, Pieper, Claus C., additional, Kuetting, Daniel, additional, Faridi, Bettina, additional, Strizek, Brigitte, additional, Attenberger, Ulrike, additional, Kipfmueller, Florian, additional, Herberg, Ulrike, additional, Geipel, Annegret, additional, and Luetkens, Julian A., additional

Published
2023
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47. Multicenter clinical experience with non‐invasive cell‐free DNA screening for monosomy X and related X‐chromosome variants

Author

Bedei, Ivonne, primary, Gehrke, Tascha, additional, Gloning, Karl‐Philipp, additional, Meyer‐Wittkopf, Matthias, additional, Willner, Daria, additional, Krapp, Martin, additional, Scharf, Alexander, additional, Degenhardt, Jan, additional, Heling, Kai‐Sven, additional, Kozlowski, Peter, additional, Trautmann, Kathrin, additional, Jahns, Kai M., additional, Geipel, Annegret, additional, Baumüller, Jan‐Erik, additional, Wilhelm, Lucas, additional, Gottschalk, Ingo, additional, Schröer, Andreas, additional, Graf, Alexander, additional, Wolter, Aline, additional, Schenk, Johanna, additional, Weber, Axel, additional, Van den Veyver, Ignatia B., additional, and Axt‐Fliedner, Roland, additional

Published
2023
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48. Survival in very preterm infants with congenital diaphragmatic hernia and association with prenatal imaging markers:A retrospective cohort study

Author

Horn-Oudshoorn, Emily J J, Russo, Francesca M, Deprest, Jan A, Kipfmueller, Florian, Geipel, Annegret, Schaible, Thomas, Rafat, Neysan, Cordier, Anne-Gael, Benachi, Alexandra, Abbasi, Nimrah, Chiu, Priscilla P L, de Boode, Willem P, Sikkel, Esther, Peters, Nina C J, Hansen, Bettina E, Reiss, Irwin K M, DeKoninck, Philip L J, Horn-Oudshoorn, Emily J J, Russo, Francesca M, Deprest, Jan A, Kipfmueller, Florian, Geipel, Annegret, Schaible, Thomas, Rafat, Neysan, Cordier, Anne-Gael, Benachi, Alexandra, Abbasi, Nimrah, Chiu, Priscilla P L, de Boode, Willem P, Sikkel, Esther, Peters, Nina C J, Hansen, Bettina E, Reiss, Irwin K M, and DeKoninck, Philip L J

Abstract

Objectives: To describe the outcomes of preterm born infants with congenital diaphragmatic hernia (CDH; ≤32.0 weeks of gestation) and the associations between prenatal imaging markers and survival. Design: Retrospective cohort study. Setting: Multicentre study in large referral centres. Population: Infants with an isolated unilateral CDH, live born at 32.0 weeks or less of gestation, between January 2009 and January 2020. Methods: Neonatal outcomes were evaluated for infants that were expectantly managed during pregnancy and infants that underwent fetoscopic endoluminal tracheal occlusion (FETO) therapy, separately. We evaluated the association between prenatal imaging markers and survival to discharge. Prenatal imaging markers included observed to expected lung-to-head ratio (o/e LHR), side of the defect, liver position, stomach position grade, and observed to expected total fetal lung volume (o/e TFLV). Main Outcome Measure: Survival to discharge. Results: We included 53 infants born at 30 +4 (interquartile range 29 +1–31 +2) weeks. Survival in fetuses expectantly managed during pregnancy was 48% (13/27) in left-sided CDH and 33% (2/6) in right-sided CDH. Survival in fetuses that underwent FETO therapy was 50% (6/12) in left-sided CDH and 25% (2/8) in right-sided CDH. The o/e LHR at baseline was positively associated with survival in cases expectantly managed during pregnancy (odds ratio [OR] 1.20, 95% CI 1.07–1.42, p < 0.01), but not in cases that received FETO therapy (OR 1.01, 95% CI 0.88–1.15, p = 0.87). Stomach position grade (p = 0.03) and o/e TFLV were associated with survival (p = 0.02); liver position was not (p = 0.13). Conclusions: In infants with CDH born at or before 32 weeks of gestation, prenatal imaging markers of disease severity were associated with postnatal survival.

Published
2023

50. Prenatal ultrasound in fetuses with polycystic kidney appearance — expanding the diagnostic algorithm.

Author

Simonini, Corinna, Fröschen, Eva-Maria, Nadal, Jennifer, Strizek, Brigitte, Berg, Christoph, Geipel, Annegret, and Gembruch, Ulrich

Subjects
AUTOSOMAL recessive polycystic kidney, POLYCYSTIC kidney disease, GONADAL dysgenesis, KIDNEY diseases, AMNIOTIC liquid, LAURENCE-Moon-Biedl syndrome
Abstract

Purpose: Report on the diagnosis of prenatally detected fetal kidneys with bilateral polycystic appearance in a single center between 1999 and 2020 with special focus on renal morphology and biometry, amniotic fluid and extrarenal findings and proposal for an diagnostic algorithm. Methods: Retrospective observational study including pregnancies with prenatally detected kidneys with bilateral polycystic appearance (n = 98). Cases and outcomes were compared according to prenatal findings with special focus on renal morphology, amount of amniotic fluid, and presence of extrarenal abnormalities. Results: Most frequent diagnoses were autosomal recessive polycystic kidney disease (ARPKD, 53.1%), Meckel–Gruber syndrome (MKS, 17.3%) and autosomal dominant polycystic kidney disease (ADPKD, 8.2%). Other diagnoses included: Joubert-, Jeune-, McKusick–Kaufman- and Bardet–Biedl syndrome, overgrowth syndromes, Mainzer–Saldino syndrome and renal tubular dysgenesis. Renal abnormalities most frequently observed were hyperechogenic parenchyma, kidney enlargement, changes of corticomedullary differentiation and cystic changes of various degree. Oligo- and anhydramnios were mainly seen in ARPKD, RTD and second-trimester MKS. Extrarenal findings included skeletal (35.7%) and cardiac (34.7%) abnormalities as well as abnormalities of the central nervous system (27.6%). Conclusion: Gestational age at manifestation, kidney size, visibility of cysts, echogenicity, amniotic fluid volume, and the presence of associated extrarenal malformations allow to differentiate between the most frequent underlying diseases presenting with bilateral polycystic kidneys on prenatal ultrasound by following a diagnostic algorithm. [ABSTRACT FROM AUTHOR]

Published
2023
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