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Resumo: A consciência de que a prática médica deve estar fundamentada na postura ética dos profissionais leva à crescente importância de um ensino de ética continuado e aprofundado, que ressalte os valores morais e humanos e o comprometimento social dos estudantes. Buscando adequar-se a esse novo paradigma, estudantes de Medicina da Universidade Federal da Bahia aceitaram a sugestão da criação, em novembro de 2000, de um grupo denominado Academética - Associação de Acadêmicos para o Estudo da Ética Médica e Bioética. Os objetivos traçados pela equipe são: continuar o contato com o conteúdo da disciplina Ética Médica, aprofundando e atualizando as discussões acerca de Ética Médica e Bioética, e desenvolver trabalhos ligados a este assunto. As discussões de temas são realizadas através do estudo de artigos, vídeos e estímulo à partidpação dos estudantes em congressos, palestras e afins. Desta forma, a Academética se constitui em mais uma ferramenta para que os alunos durante a graduação na faculdade de Medicina possam desenvolver o senso crítico e conhecimento acerca de assuntos que englobem a Ética Médica e Bioétia.

Context Hot flashes (HFs) and sexual dysfunction often affect breast cancer (BC) survivors and compromise their quality of life. Bupropion is an antidepressive medication used for smoking cessation and also has been previously studied for the treatment of sexual dysfunction. Objectives We aimed to evaluate bupropion's efficacy in controlling HFs in BC survivors. Methods This was a randomized, double-blind, crossover, placebo-controlled pilot study that enrolled 55 BC survivors who reported more than seven HFs per week. Subjects were randomized to receive either bupropion 150mg twice daily for four weeks followed by one week of washout and four more weeks of placebo twice daily or vice versa. The primary end point was average daily HF activity (number of HFs and a score combining number and severity) reported while on bupropion or on placebo. Secondary end points were sexual dysfunction, depression, and quality of life evaluated with the Arizona Sexual Experience Scale, Beck Depression Inventory, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30, respectively. Results Bupropion reduced HFs by 1.26 per day and the HF score by 6.31%, whereas placebo reduced HFs by 2.11 per day ( P >0.05) and the HF score by 30.47% ( P >0.05). There were no statistically significant differences between bupropion and placebo in the Arizona Sexual Experience Scale, Beck Depression Inventory, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30. At the end of the study, 47% of the patients preferred bupropion, whereas 53% preferred placebo. There were no statistically significant differences in side effects between the study groups. Conclusion Compared with placebo, bupropion did not control HFs in this group of BC survivors.

OBJETIVOS: Avaliar o interesse e o conhecimento sobre ética médica e bioética na graduação médica. MÉTODOS: Estudo transversal e descritivo. Foram utilizados dois questionários auto-aplicáveis, um para docentes e outro para discentes, com questões sobre o interesse em ética médica e bioética e conhecimento sobre o Código de Ética Médica (CEM). RESULTADOS: Foram avaliados 101 professores e 331 estudantes. O CEM brasileiro foi lido por 86,2% dos professores e 100% dos alunos. A importância dada à disciplina de ética médica, numa escala de 1 a 5, foi semelhante entre professores e estudantes (4,7 ± 0,7 vs. 4,5 ± 0,8; p = 0,086), enquanto o autoconhecimento sobre o tema foi maior no primeiro grupo (3,4 ± 0,9 vs. 3,2 ± 0,7; p = 0,017). De um total de nove questões avaliadas sobre o conhecimento do CEM, a média de acertos foi de 5,0 ± 1,9 questões para os professores e de 5,9 ± 1,5 para os acadêmicos (p < 0,001), sendo os acertos correlacionados positivamente com a leitura do código. CONCLUSÕES: Este estudo fornece um panorama inédito sobre a percepção de professores e estudantes de Medicina sobre a ética médica e bioética, podendo servir para fundamentar a melhora do ensino dessa disciplina em nossas faculdades. OBJECTIVES: To evaluate the interest and knowledge about Medical Ethics and Bioethics in medical graduation. METHODS: Transversal and descriptive study. Two different questionnaires were applied with questions about the interest in Medical Ethics and Bioethics and the knowledge about the Brazilian Code of Medical Ethics (CME), one to professors and the other to students. RESULTS: One hundred and one professors and 331 students answered the questionnaires. The Brazilian CME had been read by 86.2% of the teachers and by 100% of the students. The importance given to the discipline Medical Ethics, on a scale from 1 to 5, was similar among teachers and students (4.7 ± 0.7 vs. 4.5 ± 0.8; p = 0.086); however the self-evaluation on knowledge about this subject was higher in the first group (3.4 ± 0.9 vs. 3.2 ± 0.7; p = 0.017). In a block with 9 questions, the right answer was given by 5,0 ± 1.9 of teachers and 5.9 ± 1.5 of students (p < 0,001); the mean of correct answers were related to the reading of the CME. CONCLUSIONS: The present study presents unpublished data about the perception of medical teachers and students about medical ethics and bioethics and can be useful for improving the teaching of these disciplines in our medical schools. Universidade Federal da Bahia Escola Bahiana de Medicina e Saúde Pública Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Hospital São Paulo Instituto do coração da Bahia Hospital Ana Nery Universidade Federal da Bahia Hospital Universitário Professor Edgar Santos UNIFESP, EPM, Hospital São Paulo SciELO

Patients with hepatitis C virus (HCV) infection present higher risk of developing type-2 diabetes mellitus (DM). However, the mechanism of this association and the role of antiviral treatment are still unclear. The objective of this study was to investigate the relationship between the use of peguilated interferon and the development of insulin resistance (IR) in these patients. Methods: HOMA index was evaluated in 30 HCV-infected patients just before and during the first 6 months of treatment with peguilated interferon plus ribavirin. Anthropometrical parameters and glucose/cholesterol profile were also monitored. Results: No changes in HOMA after 6 months of treatment were observed. Glucose levels decreased but not significantly (P = 0.059). Patients with higher HOMA index after 6 months of treatment also presented higher aminotransferase levels (P = 0.03), higher fat index on computed tomography (P = 0.011), longer time of exposure to the virus (P = 0.021), and a positive smoking history when compared to non-insulin resistant patients (P = 0.045). There was no influence of fibrosis stage on liver biopsy in the insulin-resistance development. Conclusions: No changes in the IR were observed after 6 months of treatment. Insulin resistance is related to the abdominal fat and anthropometrical parameters rather than to the antiviral treatment. J. Med. Virol. 78:1406–1410, 2006. © 2006 Wiley-Liss, Inc.

Background Sexual morbidity after chemotherapy and hormonal therapy for breast cancer can seriously affect patients' quality of life. Bupropion is an antidepressant that has been reported to increase libido. Objective To investigate the improvement of sexual function in female breast cancer patients using bupropion. Patients and methods We performed an 8-week open trial using bupropion in women diagnosed with breast cancer who had received chemotherapy and were currently receiving adjunctive hormonal therapy. The Arizona Sexual Experience Scale (ASEX) was used. The ASEX scale includes five questions that evaluate sexual function in the following areas: libido, excitability and ability to reach orgasm. Women received oral Bupropion 150 mg/daily for 8 weeks and were evaluated prior to the initiation of the study and again during Weeks 4 and 8. Results Twenty patients were included in the study. At the beginning of the study, the mean ASEX score was 23.45 [21.67–25.24] 95% CI. After 4 weeks of treatment, we observed a reduction in the mean ASEX score that persisted until the end of the study, at eight weeks: 18.45 [16.59–20.31] 95% CI (P = 0.0003) and 18.95 [16.60–21.30] 95% CI (P = 0.0024), respectively. Conclusion In this non-controlled open trial bupropion 150 mg/daily was associated with improved sexual function in women receiving adjuvant systemic treatment for breast cancer.

Art.original (p.7-14) Submitted by ROBERTO PAULO CORREIA DE ARAÚJO (ppgorgsistem@ufba.br) on 2016-09-14T12:57:16Z No. of bitstreams: 1 R. Ci. méd. biol., v.4, n. 1-2005.pdf: 219270 bytes, checksum: 935b672d1890f2cb098e4db3e6bd5e7e (MD5) Made available in DSpace on 2016-09-14T12:57:16Z (GMT). No. of bitstreams: 1 R. Ci. méd. biol., v.4, n. 1-2005.pdf: 219270 bytes, checksum: 935b672d1890f2cb098e4db3e6bd5e7e (MD5) Previous issue date: 2005-01 A Estratégia de Atenção Integrada às Doenças Prevalentes na Infância (AIDPI) foi adotada pelo Ministério da Saúde do Brasil em 1996, sendo adaptada de acordo com as características epidemiológicas às normas nacionais de atenção à criança. Desde 1997, a AIDPI vem progressivamente sendo implantada em diversos estados brasileiros. Algumas Universidades já incluem a AIDPI no curso médico. Em dezembro de 2002, foi iniciado treinamento na estratégia AIDPI para alunos de graduação em Medicina da UFBA. O presente estudo teve como objetivo avaliar o grau de mudança no conhecimento e nas atitudes de estudantes de Medicina após treinamento na estratégia AIDPI. Foi realizado um estudo longitudinal prospectivo no período de dezembro de 2002 a junho de 2003. Catorze alunos constituíram 2 coortes que receberam treinamento na estratégia AIDPI entre dezembro de 2002 e junho de 2003. No ponto zero do acompanhamento de cada coorte, foi realizado um teste com questões referentes a temas de conhecimentos básicos em pediatria, que também fazem parte do programa do curso de treinamento m AIDPI. O teste foi repetido nos desfechos das coortes. Foram utilizados a Prova dos Sinais e o teste de Mcnemar para análise estatística das variáveis estudadas, utilizando-se o software SPSS. Após o treinamento, houve mudanças estatisticamente significativas no conhecimento dos estudantes sobre os principais sinais de doença grave, de pneumonia, de pneumonia grave, de desnutrição grave, de desidratação e do uso apropriado de vacinas. O conhecimento dos estudantes sobre a taxa de mortalidade infantil e causas de óbitos em crianças também se modificou de forma estatisticamente significativa. Houve significativa melhoria nas habilidades de orientação das técnicas adequadas para amamentação exclusiva e para introdução de outros alimentos no desmame. Os resultados demonstraram que o treinamento na estratégia AIDPI gerou modificações estatisticamente significativas nos conhecimentos e atitudes dos alunos avaliados. Salvador

Cancer antigen (CA)-125 is a useful tumor marker for the follow up of ovarian and lung cancer. It is a sensitive, but not specific, tumor marker. Increased serum CA-125 levels have already been described in a number of benign and malignant diseases. We report two cases of increased serum CA-125 levels status post thoracotomy for resection of an early stage lung tumor that regressed spontaneously 3 and 8 months following surgery. Serum CA-125 levels may increase after thoracotomy, unrelated to tumor recurrence. Therefore, CA-125 levels obtained postoperatively should be interpreted with caution.

9102 Background: Hot flashes and sexual dysfunction often affect breast cancer's survivors compromising their quality of life. Approximately 65% of women after treatment for breast cancer complain ...

6072 Background: Sexual morbidity after chemotherapy and hormonal therapy for breast cancer can seriously affect patients’ quality of life. Bupropion is an antidepressant that has been reported to increase libido. Objective: To investigate the improvement of sexual function in female breast cancer patients using bupropion. Methods: We performed an eight week open trial using bupropion in women diagnosed with breast cancer who had received chemotherapy and were currently receiving adjunctive hormonal therapy. The Arizona Sexual Experience Scale (ASEX) was used. The ASEX scale includes five questions that evaluate sexual function in the following areas: libido, excitability and ability to reach orgasm. Women received oral Bupropion 150mg/ daily for eight weeks and were evaluated prior to the initiation of the study and again during Weeks 4 and 8. Results: Twenty patients were included in the study. At the beginning of the study, the mean ASEX score was 23.45 [21.67–25.24] 95% CI. After four weeks of treatment, we observed a reduction in the mean ASEX score that persisted until the end of the study, at eight weeks: 18.45 [16.59–20.31] 95% CI, p = 0.0003) and 18.95 (SD ± 5.02 [16.60–21.30] 95% CI, p = 0.0024), respectively. Conclusions: In this non-controlled open trial bupropion 150 mg/daily was associated with improved sexual function in women receiving adjuvant systemic treatment for breast cancer. No significant financial relationships to disclose.

8058 Background: Sexual morbidity after chemotherapy and hormonal therapy for breast cancer is an important problem that can negatively affect women’s quality of life. Bupropion is an antidepressant that appears to increase libido. Methods: We performed a pilot study using Bupropion in breast cancer patients that received adjuvant chemotherapy and were currently in use of hormonal therapy diagnosed with sexual dysfunction using the Arizona Sexual Experience Scale (ASEX), validated in Portuguese. This scale contains five questions that evaluate sexual function in the following areas: libido, excitability and hability to reach orgasm. The scale is coded, for each item as 1 (normal) to 6 (totally absent). Women received oral Bupropion 150mg/ daily for eight weeks and the ASEX, Beck’s Depression and the EORTC Q30 scales were applied prior to initiation of the study and on weeks 4 and 8. Results: Eight pacients were included in the study. The mean age was 49,75 +/- 3,95. Seventy five percent were married and 2...