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1. Corrigendum to “Dissecting the genetic heterogeneity of gastric cancer”

Author

Hess, Timo, primary, Maj, Carlo, additional, Gehlen, Jan, additional, Borisov, Oleg, additional, Haas, Stephan L., additional, Gockel, Ines, additional, Vieth, Michael, additional, Piessen, Guillaume, additional, Alakus, Hakan, additional, Vashist, Yogesh, additional, Pereira, Carina, additional, Knapp, Michael, additional, Schüller, Vitalia, additional, Quaas, Alexander, additional, Grabsch, Heike I., additional, Trautmann, Jessica, additional, Malecka-Wojciesko, Ewa, additional, Mokrowiecka, Anna, additional, Speller, Jan, additional, Mayr, Andreas, additional, Schröder, Julia, additional, Hillmer, Axel M., additional, Heider, Dominik, additional, Lordick, Florian, additional, Pérez-Aísa, Ángeles, additional, Campo, Rafael, additional, Espinel, Jesús, additional, Geijo, Fernando, additional, Thomson, Concha, additional, Bujanda, Luis, additional, Sopeña, Federico, additional, Lanas, Ángel, additional, Pellisé, María, additional, Pauligk, Claudia, additional, Goetze, Thorsten Oliver, additional, Zelck, Carolin, additional, Reingruber, Julian, additional, Hassanin, Emadeldin, additional, Elbe, Peter, additional, Alsabeah, Sandra, additional, Lindblad, Mats, additional, Nilsson, Magnus, additional, Kreuser, Nicole, additional, Thieme, René, additional, Tavano, Francesca, additional, Pastorino, Roberta, additional, Arzani, Dario, additional, Persiani, Roberto, additional, Jung, Jin-On, additional, Nienhüser, Henrik, additional, Ott, Katja, additional, Schumann, Ralf R., additional, Kumpf, Oliver, additional, Burock, Susen, additional, Arndt, Volker, additional, Jakubowska, Anna, additional, Ławniczak, Małgorzta, additional, Moreno, Victor, additional, Martín, Vicente, additional, Kogevinas, Manolis, additional, Pollán, Marina, additional, Dąbrowska, Justyna, additional, Salas, Antonio, additional, Cussenot, Olivier, additional, Boland-Auge, Anne, additional, Daian, Delphine, additional, Deleuze, Jean-Francois, additional, Salvi, Erika, additional, Teder-Laving, Maris, additional, Tomasello, Gianluca, additional, Ratti, Margherita, additional, Senti, Chiara, additional, De Re, Valli, additional, Steffan, Agostino, additional, Hölscher, Arnulf H., additional, Messerle, Katharina, additional, Bruns, Christiane Josephine, additional, Sīviņš, Armands, additional, Bogdanova, Inga, additional, Skieceviciene, Jurgita, additional, Arstikyte, Justina, additional, Moehler, Markus, additional, Lang, Hauke, additional, Grimminger, Peter P., additional, Kruschewski, Martin, additional, Vassos, Nikolaos, additional, Schildberg, Claus, additional, Lingohr, Philipp, additional, Ridwelski, Karsten, additional, Lippert, Hans, additional, Fricker, Nadine, additional, Krawitz, Peter, additional, Hoffmann, Per, additional, Nöthen, Markus M., additional, Veits, Lothar, additional, Izbicki, Jakob R., additional, Mostowska, Adrianna, additional, Martinón-Torres, Federico, additional, Cusi, Daniele, additional, Adolfsson, Rolf, additional, Cancel-Tassin, Geraldine, additional, Höblinger, Aksana, additional, Rodermann, Ernst, additional, Ludwig, Monika, additional, Keller, Gisela, additional, Metspalu, Andres, additional, Brenner, Hermann, additional, Heller, Joerg, additional, Neef, Markus, additional, Schepke, Michael, additional, Dumoulin, Franz Ludwig, additional, Hamann, Lutz, additional, Cannizzaro, Renato, additional, Ghidini, Michele, additional, Plaßmann, Dominik, additional, Geppert, Michael, additional, Malfertheiner, Peter, additional, Glehen, Olivier, additional, Skoczylas, Tomasz, additional, Majewski, Marek, additional, Lubiński, Jan, additional, Palmieri, Orazio, additional, Boccia, Stefania, additional, Latiano, Anna, additional, Aragones, Nuria, additional, Schmidt, Thomas, additional, Dinis-Ribeiro, Mário, additional, Medeiros, Rui, additional, Al-Batran, Salah-Eddin, additional, Leja, Mārcis, additional, Kupcinskas, Juozas, additional, García-González, María A., additional, Venerito, Marino, additional, and Schumacher, Johannes, additional

Published
2023
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4. RESCATE DE CUERPO EXTRAÑO BILIAR MEDIANTE COLANGIOSCOPIA

Author

Domínguez, Raquel, primary, Menéndez, Ana, additional, Segarra, José Xavier, additional, Tejerizo, Laura, additional, Gómez, Rocío, additional, Aranda, Gonzalo, additional, Andreo, Belén Encarnación, additional, Velasco, Antonio José, additional, Geijo, Fernando, additional, and Álvarez, Alberto, additional

Published
2023
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6. GASTROYEYUNOSTOMÍA GUIADA POR ECOENDOSCOPIA FRENTE A PRÓTESIS ENTERAL ENDOSCÓPICA EN LA OBSTRUCCIÓN MALIGNA AL VACIAMIENTO GÁSTRICO NO RESECABLE. ESTUDIO COMPARATIVO.

Author

Tejerizo, Laura, primary, Velasco, Antonio José, additional, Domínguez, Raquel, additional, Segarra, Jose Xavier, additional, Gómez, Rocío, additional, Menéndez, Ana, additional, Aranda, Gonzalo, additional, Andreo, Belén Encarnación, additional, Geijo, Fernando, additional, and Álvarez, Alberto, additional

Published
2023
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8. ENTEROSCOPIA EN EL DIAGNÓSTICO DE DIARREA CRÓNICA

Author

Segarra, José Xavier, primary, Velasco, Antonio José, additional, Tejerizo, Laura, additional, Gómez, Rocío, additional, Andreo, Belén Encarnación, additional, Aranda, Gonzalo, additional, Piñero, María Concepción, additional, García, María, additional, Geijo, Fernando, additional, and Álvarez, Alberto, additional

Published
2023
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10. MUCOSECTOMÍA ESOFÁGICA CON BANDAS EN PACIENTE CON VARICES ESOFÁGICAS. ÉXITO ENDOSCÓPICO Y RESOLUCIÓN DE LAS COMPLICACIONES.

Author

Domínguez, Raquel, primary, Velasco, Antonio José, additional, Marcos, Ángel Francisco, additional, Menéndez, Ana, additional, Tejerizo, Laura, additional, Segarra, José Xavier, additional, Gómez, Rocío, additional, Andreo, Belén Encarnación, additional, Geijo, Fernando, additional, and Álvarez, Alberto, additional

Published
2023
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12. Dissecting the genetic heterogeneity of gastric cancer

Author

Hess, Timo, primary, Maj, Carlo, additional, Gehlen, Jan, additional, Borisov, Oleg, additional, Haas, Stephan L., additional, Gockel, Ines, additional, Vieth, Michael, additional, Piessen, Guillaume, additional, Alakus, Hakan, additional, Vashist, Yogesh, additional, Pereira, Carina, additional, Knapp, Michael, additional, Schüller, Vitalia, additional, Quaas, Alexander, additional, Grabsch, Heike I., additional, Trautmann, Jessica, additional, Malecka-Wojciesko, Ewa, additional, Mokrowiecka, Anna, additional, Speller, Jan, additional, Mayr, Andreas, additional, Schröder, Julia, additional, Hillmer, Axel M., additional, Heider, Dominik, additional, Lordick, Florian, additional, Pérez-Aísa, Ángeles, additional, Campo, Rafael, additional, Espinel, Jesús, additional, Geijo, Fernando, additional, Thomson, Concha, additional, Bujanda, Luis, additional, Sopeña, Federico, additional, Lanas, Ángel, additional, Pellisé, María, additional, Pauligk, Claudia, additional, Goetze, Thorsten Oliver, additional, Zelck, Carolin, additional, Reingruber, Julian, additional, Hassanin, Emadeldin, additional, Elbe, Peter, additional, Alsabeah, Sandra, additional, Lindblad, Mats, additional, Nilsson, Magnus, additional, Kreuser, Nicole, additional, Thieme, René, additional, Tavano, Francesca, additional, Pastorino, Roberta, additional, Arzani, Dario, additional, Persiani, Roberto, additional, Jung, Jin-On, additional, Nienhüser, Henrik, additional, Ott, Katja, additional, Schumann, Ralf R., additional, Kumpf, Oliver, additional, Burock, Susen, additional, Arndt, Volker, additional, Jakubowska, Anna, additional, Ławniczak, Małgorzta, additional, Moreno, Victor, additional, Martín, Vicente, additional, Kogevinas, Manolis, additional, Pollán, Marina, additional, Dąbrowska, Justyna, additional, Salas, Antonio, additional, Cussenot, Olivier, additional, Boland-Auge, Anne, additional, Daian, Delphine, additional, Deleuze, Jean-Francois, additional, Salvi, Erika, additional, Teder-Laving, Maris, additional, Tomasello, Gianluca, additional, Ratti, Margherita, additional, Senti, Chiara, additional, De Re, Valli, additional, Steffan, Agostino, additional, Hölscher, Arnulf H., additional, Messerle, Katharina, additional, Bruns, Christiane Josephine, additional, Sīviņš, Armands, additional, Bogdanova, Inga, additional, Skieceviciene, Jurgita, additional, Arstikyte, Justina, additional, Moehler, Markus, additional, Lang, Hauke, additional, Grimminger, Peter P., additional, Kruschewski, Martin, additional, Vassos, Nikolaos, additional, Schildberg, Claus, additional, Lingohr, Philipp, additional, Ridwelski, Karsten, additional, Lippert, Hans, additional, Fricker, Nadine, additional, Krawitz, Peter, additional, Hoffmann, Per, additional, Nöthen, Markus M., additional, Veits, Lothar, additional, Izbicki, Jakob R., additional, Mostowska, Adrianna, additional, Martinón-Torres, Federico, additional, Cusi, Daniele, additional, Adolfsson, Rolf, additional, Cancel-Tassin, Geraldine, additional, Höblinger, Aksana, additional, Rodermann, Ernst, additional, Ludwig, Monika, additional, Keller, Gisela, additional, Metspalu, Andres, additional, Brenner, Hermann, additional, Heller, Joerg, additional, Neef, Markus, additional, Schepke, Michael, additional, Dumoulin, Franz Ludwig, additional, Hamann, Lutz, additional, Cannizzaro, Renato, additional, Ghidini, Michele, additional, Plaßmann, Dominik, additional, Geppert, Michael, additional, Malfertheiner, Peter, additional, Gehlen, Olivier, additional, Skoczylas, Tomasz, additional, Majewski, Marek, additional, Lubiński, Jan, additional, Palmieri, Orazio, additional, Boccia, Stefania, additional, Latiano, Anna, additional, Aragones, Nuria, additional, Schmidt, Thomas, additional, Dinis-Ribeiro, Mário, additional, Medeiros, Rui, additional, Al-Batran, Salah-Eddin, additional, Leja, Mārcis, additional, Kupcinskas, Juozas, additional, García-González, María A., additional, Venerito, Marino, additional, and Schumacher, Johannes, additional

Published
2023
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13. Dissecting the genetic heterogeneity of gastric cancer

Author

Hess, Timo, Maj, Carlo, Gehlen, Jan, Borisov, Oleg, Haas, Stephan L., Gockel, Ines, Vieth, Michael, Piessen, Guillaume, Alakus, Hakan, Vashist, Yogesh, Pereira, Carina, Knapp, Michael, Schüller, Vitalia, Quaas, Alexander, Grabsch, Heike I., Trautmann, Jessica, Malecka-Wojciesko, Ewa, Mokrowiecka, Anna, Speller, Jan, Mayr, Andreas, Schröder, Julia, Hillmer, Axel M., Heider, Dominik, Lordick, Florian, Pérez-Aísa, Ángeles, Campo, Rafael, Espinel, Jesús, Geijo, Fernando, Thomson, Concha, Bujanda, Luis, Sopeña, Federico, Lanas, Ángel, Pellisé, María, Pauligk, Claudia, Goetze, Thorsten Oliver, Zelck, Carolin, Reingruber, Julian, Hassanin, Emadeldin, Elbe, Peter, Alsabeah, Sandra, Lindblad, Mats, Nilsson, Magnus, Kreuser, Nicole, Thieme, René, Tavano, Francesca, Pastorino, Roberta, Arzani, Dario, Persiani, Roberto, Jung, Jin-On, Nienhüser, Henrik, Ott, Katja, Schumann, Ralf R., Kumpf, Oliver, Burock, Susen, Arndt, Volker, Jakubowska, Anna, Ławniczak, Małgorzta, Moreno, Victor, Martín, Vicente, Kogevinas, Manolis, Pollán, Marina, Dąbrowska, Justyna, Salas, Antonio, Cussenot, Olivier, Boland-Auge, Anne, Daian, Delphine, Deleuze, Jean-Francois, Salvi, Erika, Teder-Laving, Maris, Tomasello, Gianluca, Ratti, Margherita, Senti, Chiara, De Re, Valli, Steffan, Agostino, Hölscher, Arnulf H., Messerle, Katharina, Bruns, Christiane Josephine, Sīviņš, Armands, Bogdanova, Inga, Skieceviciene, Jurgita, Arstikyte, Justina, Moehler, Markus, Lang, Hauke, Grimminger, Peter P., Kruschewski, Martin, Vassos, Nikolaos, Schildberg, Claus, Lingohr, Philipp, Ridwelski, Karsten, Lippert, Hans, Fricker, Nadine, Krawitz, Peter, Hoffmann, Per, Nöthen, Markus M., Veits, Lothar, Izbicki, Jakob R., Mostowska, Adrianna, Martinón-Torres, Federico, Cusi, Daniele, Adolfsson, Rolf, Cancel-Tassin, Geraldine, Höblinger, Aksana, Rodermann, Ernst, Ludwig, Monika, Keller, Gisela, Metspalu, Andres, Brenner, Hermann, Heller, Joerg, Neef, Markus, Schepke, Michael, Dumoulin, Franz Ludwig, Hamann, Lutz, Cannizzaro, Renato, Ghidini, Michele, Plaßmann, Dominik, Geppert, Michael, Malfertheiner, Peter, Gehlen, Olivier, Skoczylas, Tomasz, Majewski, Marek, Lubiński, Jan, Palmieri, Orazio, Boccia, Stefania, Latiano, Anna, Aragones, Nuria, Schmidt, Thomas, Dinis-Ribeiro, Mário, Medeiros, Rui, Al-Batran, Salah-Eddin, Leja, Mārcis, Kupcinskas, Juozas, García-González, María A., Venerito, Marino, Schumacher, Johannes, Hess, Timo, Maj, Carlo, Gehlen, Jan, Borisov, Oleg, Haas, Stephan L., Gockel, Ines, Vieth, Michael, Piessen, Guillaume, Alakus, Hakan, Vashist, Yogesh, Pereira, Carina, Knapp, Michael, Schüller, Vitalia, Quaas, Alexander, Grabsch, Heike I., Trautmann, Jessica, Malecka-Wojciesko, Ewa, Mokrowiecka, Anna, Speller, Jan, Mayr, Andreas, Schröder, Julia, Hillmer, Axel M., Heider, Dominik, Lordick, Florian, Pérez-Aísa, Ángeles, Campo, Rafael, Espinel, Jesús, Geijo, Fernando, Thomson, Concha, Bujanda, Luis, Sopeña, Federico, Lanas, Ángel, Pellisé, María, Pauligk, Claudia, Goetze, Thorsten Oliver, Zelck, Carolin, Reingruber, Julian, Hassanin, Emadeldin, Elbe, Peter, Alsabeah, Sandra, Lindblad, Mats, Nilsson, Magnus, Kreuser, Nicole, Thieme, René, Tavano, Francesca, Pastorino, Roberta, Arzani, Dario, Persiani, Roberto, Jung, Jin-On, Nienhüser, Henrik, Ott, Katja, Schumann, Ralf R., Kumpf, Oliver, Burock, Susen, Arndt, Volker, Jakubowska, Anna, Ławniczak, Małgorzta, Moreno, Victor, Martín, Vicente, Kogevinas, Manolis, Pollán, Marina, Dąbrowska, Justyna, Salas, Antonio, Cussenot, Olivier, Boland-Auge, Anne, Daian, Delphine, Deleuze, Jean-Francois, Salvi, Erika, Teder-Laving, Maris, Tomasello, Gianluca, Ratti, Margherita, Senti, Chiara, De Re, Valli, Steffan, Agostino, Hölscher, Arnulf H., Messerle, Katharina, Bruns, Christiane Josephine, Sīviņš, Armands, Bogdanova, Inga, Skieceviciene, Jurgita, Arstikyte, Justina, Moehler, Markus, Lang, Hauke, Grimminger, Peter P., Kruschewski, Martin, Vassos, Nikolaos, Schildberg, Claus, Lingohr, Philipp, Ridwelski, Karsten, Lippert, Hans, Fricker, Nadine, Krawitz, Peter, Hoffmann, Per, Nöthen, Markus M., Veits, Lothar, Izbicki, Jakob R., Mostowska, Adrianna, Martinón-Torres, Federico, Cusi, Daniele, Adolfsson, Rolf, Cancel-Tassin, Geraldine, Höblinger, Aksana, Rodermann, Ernst, Ludwig, Monika, Keller, Gisela, Metspalu, Andres, Brenner, Hermann, Heller, Joerg, Neef, Markus, Schepke, Michael, Dumoulin, Franz Ludwig, Hamann, Lutz, Cannizzaro, Renato, Ghidini, Michele, Plaßmann, Dominik, Geppert, Michael, Malfertheiner, Peter, Gehlen, Olivier, Skoczylas, Tomasz, Majewski, Marek, Lubiński, Jan, Palmieri, Orazio, Boccia, Stefania, Latiano, Anna, Aragones, Nuria, Schmidt, Thomas, Dinis-Ribeiro, Mário, Medeiros, Rui, Al-Batran, Salah-Eddin, Leja, Mārcis, Kupcinskas, Juozas, García-González, María A., Venerito, Marino, and Schumacher, Johannes

Abstract

Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes. Another aim was to examine whether cardia GC and oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO), which are all located at the gastro-oesophageal junction (GOJ), share polygenic risk architecture. Methods: We did a meta-analysis of ten European genome-wide association studies (GWAS) of GC and its subtypes. All patients had a histopathologically confirmed diagnosis of gastric adenocarcinoma. For the identification of risk genes among GWAS loci we did a transcriptome-wide association study (TWAS) and expression quantitative trait locus (eQTL) study from gastric corpus and antrum mucosa. To test whether cardia GC and OAC/BO share genetic aetiology we also used a European GWAS sample with OAC/BO. Findings: Our GWAS consisting of 5816 patients and 10,999 controls highlights the genetic heterogeneity of GC according to its subtypes. We newly identified two and replicated five GC risk loci, all of them with subtype-specific association. The gastric transcriptome data consisting of 361 corpus and 342 antrum mucosa samples revealed that an upregulated expression of MUC1, ANKRD50, PTGER4, and PSCA are plausible GC-pathomechanisms at four GWAS loci. At another risk locus, we found that the blood-group 0 exerts protective effects for non-cardia and diffuse GC, while blood-group A increases risk for both GC subtypes. Furthermore, our GWAS on cardia GC and OAC/BO (10,279 patients, 16,527 controls) showed that both cancer entities share genetic aetiology at the polygenic level and identified two new risk loci on the single-marker level. Interpretation: Our findings show that the pathophysiology of GC is genetically heterogenous according to location and histopathology. Moreover, our findings point to common molecular me, Errata: Hess, T., Maj, C., Gehlen, J. et. al. Corrigendum to “Dissecting the genetic heterogeneity of gastric cancer”. eBioMedicine. 2023:94:104709. DOI: 10.1016/j.ebiom.2023.104709

Published
2023
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14. DISECCIÓN ENDOSCÓPICA SUBMUCOSA EN BLOQUE SOBRE LESIÓN ESOFÁGICA ESCAMOSA SUPERFICIAL DE GRAN TAMAÑO Y AFECTACIÓN CIRCUNFERENCIAL EN PACIENTE CON VARICES ESOFÁGICAS. DESAFIO ENDOSCÓPICO.

Author

Domínguez, Raquel, primary, Rodríguez, Enrique, additional, Velasco, Antonio José, additional, Menéndez, Ana, additional, Tejerizo, Laura, additional, Segarra, José Xavier, additional, Gómez, Rocío, additional, Joao, Diana, additional, Geijo, Fernando, additional, and Álvarez, Alberto, additional

Published
2022
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18. LITOTRICIA ELECTROHIDRÁULICA EN EL MANEJO DE COLEDOCOLITIASIS DIFÍCILES MEDIANTE COLANGIOSCOPIA TIPO SPYGLASS. EFICACIA Y SEGURIDAD

Author

SEGARRA, JOSE XAVIER, primary, TEJERIZO, LAURA, additional, DOMÍNGUEZ, RAQUEL, additional, MENÉNDEZ, ANA, additional, GÓMEZ, ROCIO, additional, ANDREO, BELÉN ENCARNACIÓN, additional, ARANDA, GONZALO, additional, GEIJO, FERNANDO, additional, VELASCO, ANTONIO JOSÉ, additional, and ALVAREZ, ALBERTO, additional

Published
2022
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24. Causa infrecuente de rectorragia: Fístula colecisto-colónica.

Author

Parras, Ernesto, primary, Antona, Marta, additional, Domínguez, Raquel, additional, Menéndez, Ana, additional, Tejerizo, Laura, additional, Segarra, Jose Xavier, additional, Gómez, Rocío, additional, García, María, additional, Geijo, Fernando, additional, and Álvarez, Alberto, additional

Published
2021
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25. ECOENDOSCOPIA EN EL DIAGNÓSTICO DE PATOLOGÍA TUMORAL AÓRTICA

Author

Domínguez, Raquel, primary, Menéndez, Ana, additional, Parras, Ernesto, additional, Antona, Marta, additional, Tejerizo, Laura, additional, Segarra, José Xavier, additional, Gómez, Rocío, additional, Roldán, Marta, additional, Geijo, Fernando, additional, and Álvarez, Alberto, additional

Published
2021
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29. Association of PSCA rs2294008 gene variants with poor prognosis and increased susceptibility to gastric cancer and decreased risk of duodenal ulcer disease

Author

García-González, María Asunción, Bujanda, Luis, Quintero, Enrique, Santolaria, Santos, Benito, Rafael, Strunk, Mark, Sopeña, Federico, Thomson, Concha, Pérez-Aisa, Angeles, Nicolás-Pérez, David, Hijona, Elizabeth, Carrera-Lasfuentes, Patricia, Piazuelo, Elena, Jiménez, Pilar, Espinel, Jesús, Campo, Rafael, Manzano, Marisa, Geijo, Fernando, Pellise, María, Zaballa, Manuel, González-Huix, Ferrán, Espinós, Jorge, Titó, Llúcia, Barranco, Luis, Pazo-Cid, Roberto, and Lanas, Angel

Published
2015
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30. Long-term safety and efficacy study of a medical device containing xyloglucan, pea protein reticulated with tannins and xylo-oligosaccharides, in patients with diarrhoea-predominant irritable bowel syndrome

Author

Universidad de Sevilla. Departamento de Medicina, Ciriza de los Ríos, Constanza, Serrano Falcón, Blanca, Argüelles Arias, Federico, Pérez, Esperanza, Teruel, Carlos, Geijo, Fernando, Rey, Enrique, Universidad de Sevilla. Departamento de Medicina, Ciriza de los Ríos, Constanza, Serrano Falcón, Blanca, Argüelles Arias, Federico, Pérez, Esperanza, Teruel, Carlos, Geijo, Fernando, and Rey, Enrique

Abstract

Background: Irritable bowel syndrome with diarrhoea (IBS-D) is a frequent problem associated with a significant socioeconomic implication. Increased gut permeability is an important pathophysiological mechanism. A medical device containing xyloglucan (XG), pea protein and tannins (PPT) from grape-seed extract, and xylo-oligosaccharides (XOS) has proven restoration of intestinal barrier function. Our objective was to evaluate the efficacy and safety of treatment with the medical device XG + PPT + XOS (XG-PPT-XOS) in adult patients with IBS-D in a clinical setting for 6 months. Material and methods: This was a multicentre, open-label, prospective, observational study conducted to evaluate long-term safety and efficacy of XG-PPT-XOS. IBS-D adult patients (Rome IV criteria) were included and received two tablets twice daily for 6 months. IBS Symptom Severity Score (IBS-SSS) and bowel habit were registered at baseline and monthly, until the end of follow up. Efficacy was evaluated by comparison of mean scores at each time point. Results: 50 patients were included, of which 19 completed the 6 months. IBS-SSS score decreased from 312.2 ± 82.2 to 213.6 ± 109.9 (p < 0.0001) at 1 month and 192.0 ± 108.9 at the last visit completed; diarrhoea score decreased from 45.6 ± 17.9 to 25.7 ± 17.7 and 25.3 ± 17.2 at 1 month and at the last visit completed, respectively. Pain score decreased from 107.8 ± 49.9 at baseline to 73.2 ± 57.3 (p < 0.0001) at 1 month and bloating score from 56.4 ± 28.8 at baseline to 42.8 ± 32.6 (p < 0.001) at 1 month, reaching 62.4 ± 56.0 and 40.4 ± 34.3, respectively, at the last visit completed. Adverse effects were mild and mostly not related to treatment. Conclusion: Treating IBS-D patients with XG-PPT-XOS is effective and safe in the long term within a clinical setting, improving all IBS-D symptoms from the first month of treatment and showing a sustained response over the term of therapy.

Published
2021

32. Relevance of GSTM1, GSTT1, and GSTP1 gene polymorphisms to gastric cancer susceptibility and phenotype

Author

García-González, M Asunción, Quintero, Enrique, Bujanda, Luis, Nicolás, David, Benito, Rafael, Strunk, Mark, Santolaria, Santos, Sopeña, Federico, Badía, María, Hijona, Elizabeth, Pérez-Aísa, M Angeles, Méndez-Sánchez, Isabel M, Thomson, Concha, Carrera, Patricia, Piazuelo, Elena, Jiménez, Pilar, Espinel, Jesús, Campo, Rafael, Manzano, Marisa, Geijo, Fernando, Pellisé, Maria, González-Huix, Ferrán, Espinós, Jorge, Titó, LLusia, Zaballa, Manuel, Pazo, Roberto, and Lanas, Angel

Published
2012
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33. Refractory Benign Esophageal Stricture

Author

Velasco, Antonio, Álvarez, Alberto, Prieto, Vanesa, Geijo, Fernando, Pordomingo, Alejandra, Fradejas, Paola, Rodriguez, Antonio, and Rodriguez, Manuel T.

Published
2007

34. Gastric Cancer Susceptibility Is Not Linked to Pro-and Anti-Inflammatory Cytokine Gene Polymorphisms in Whites: A Nationwide Multicenter Study in Spain

Author

García-González, María Asunción, Lanas, Angel, Quintero, Enrique, Nicolás, David, Parra-Blanco, Adolfo, Strunk, Mark, Benito, Rafael, Simón, Miguel Angel, Santolaria, Santos, Sopeña, Federico, Piazuelo, Elena, Jiménez, Pilar, Pascual, Cristina, Mas, Eva, Irún, Pilar, Espinel, Jesús, Campo, Rafael, Manzano, Marisa, Geijo, Fernando, Pellisé, Maria, González-Huix, Ferrán, Nieto, Miguel, Espinós, Jorge, Titó, LLúcia, Bujanda, Luis, and Zaballa, Manuel

Published
2007

35. Evidence for PTGER4, PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level

Author

Heinrichs, Sophie K. M., Hess, Timo, Becker, Jessica, Hamann, Lutz, Vashist, Yogesh K., Butterbach, Katja, Schmidt, Thomas, Alakus, Hakan, Krasniuk, Iurii, Hoeblinger, Aksana, Lingohr, Philipp, Ludwig, Monika, Hagel, Alexander F., Schildberg, Claus W., Veits, Lothar, Gyvyte, Ugne, Weise, Katharina, Schueller, Vitalia, Boehmer, Anne C., Schroeder, Julia, Gehlen, Jan, Kreuser, Nicole, Hofer, Sebastian, Lang, Hauke, Lordick, Florian, Malfertheiner, Peter, Moehler, Markus, Pech, Oliver, Vassos, Nikolaos, Rodermann, Ernst, Izbicki, Jakob R., Kruschewski, Martin, Ott, Katja, Schumann, Ralf R., Vieth, Michael, Mangold, Elisabeth, Gasenko, Evita, Kupcinskas, Limas, Brenner, Hermann, Grimminger, Peter, Bujanda, Luis, Sopena, Federico, Espinel, Jesus, Thomson, Concha, Perez-Aisa, Angeles, Campo, Rafael, Geijo, Fernando, Collette, Daniela, Bruns, Christiane, Messerle, Katharina, Gockel, Ines, Noethen, Markus M., Lippert, Hans, Ridwelski, Karsten, Lanas, Angel, Keller, Gisela, Knapp, Michael, Leja, Marcis, Kupcinskas, Juozas, Garcia-Gonzalez, Maria A., Venerito, Marino, Schumacher, Johannes, Heinrichs, Sophie K. M., Hess, Timo, Becker, Jessica, Hamann, Lutz, Vashist, Yogesh K., Butterbach, Katja, Schmidt, Thomas, Alakus, Hakan, Krasniuk, Iurii, Hoeblinger, Aksana, Lingohr, Philipp, Ludwig, Monika, Hagel, Alexander F., Schildberg, Claus W., Veits, Lothar, Gyvyte, Ugne, Weise, Katharina, Schueller, Vitalia, Boehmer, Anne C., Schroeder, Julia, Gehlen, Jan, Kreuser, Nicole, Hofer, Sebastian, Lang, Hauke, Lordick, Florian, Malfertheiner, Peter, Moehler, Markus, Pech, Oliver, Vassos, Nikolaos, Rodermann, Ernst, Izbicki, Jakob R., Kruschewski, Martin, Ott, Katja, Schumann, Ralf R., Vieth, Michael, Mangold, Elisabeth, Gasenko, Evita, Kupcinskas, Limas, Brenner, Hermann, Grimminger, Peter, Bujanda, Luis, Sopena, Federico, Espinel, Jesus, Thomson, Concha, Perez-Aisa, Angeles, Campo, Rafael, Geijo, Fernando, Collette, Daniela, Bruns, Christiane, Messerle, Katharina, Gockel, Ines, Noethen, Markus M., Lippert, Hans, Ridwelski, Karsten, Lanas, Angel, Keller, Gisela, Knapp, Michael, Leja, Marcis, Kupcinskas, Juozas, Garcia-Gonzalez, Maria A., Venerito, Marino, and Schumacher, Johannes

Abstract

Genetic associations between variants on chromosome 5p13 and 8q24 and gastric cancer (GC) have been previously reported in the Asian population. We aimed to replicate these findings and to characterize the associations at the genome and transcriptome level. We performed a fine-mapping association study in 1926 GC patients and 2012 controls of European descent using high dense SNP marker sets on both chromosomal regions. Next, we performed expression quantitative trait locus (eQTL) analyses using gastric transcriptome data from 143 individuals focusing on the GC associated variants. On chromosome 5p13 the strongest association was observed at rs6872282 (P = 2.53 x 10(-04)) and on chromosome 8q24 at rs2585176 (P = 1.09 x 10(-09)). On chromosome 5p13 we found cis-eQTL effects with an up-regulation of PTGER4 expression in GC risk allele carrier (P = 9.27 x 10(-11)). On chromosome 8q24 we observed cis-eQTL effects with an upregulation of PSCA expression in GC risk allele carrier (P = 2.17 x 10(-47)). In addition, we found trans-eQTL effects for the same variants on 8q24 with a downregulation of MBOAT7 expression in GC risk allele carrier (P = 3.11 x 10(-09)). In summary, we confirmed and refined the previously reported GC associations at both chromosomal regions. Our data point to shared etiological factors between Asians and Europeans. Furthermore, our data imply an upregulated expression of PTGER4 and PSCA as well as a downregulated expression of MBOAT7 in gastric tissue as risk-conferring GC pathomechanisms.

Published
2018

36. Evidence for PTGER4 ,PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level

Author

Heinrichs, Sophie K. M., primary, Hess, Timo, additional, Becker, Jessica, additional, Hamann, Lutz, additional, Vashist, Yogesh K., additional, Butterbach, Katja, additional, Schmidt, Thomas, additional, Alakus, Hakan, additional, Krasniuk, Iurii, additional, Höblinger, Aksana, additional, Lingohr, Philipp, additional, Ludwig, Monika, additional, Hagel, Alexander F., additional, Schildberg, Claus W., additional, Veits, Lothar, additional, Gyvyte, Ugne, additional, Weise, Katharina, additional, Schüller, Vitalia, additional, Böhmer, Anne C., additional, Schröder, Julia, additional, Gehlen, Jan, additional, Kreuser, Nicole, additional, Hofer, Sebastian, additional, Lang, Hauke, additional, Lordick, Florian, additional, Malfertheiner, Peter, additional, Moehler, Markus, additional, Pech, Oliver, additional, Vassos, Nikolaos, additional, Rodermann, Ernst, additional, Izbicki, Jakob R., additional, Kruschewski, Martin, additional, Ott, Katja, additional, Schumann, Ralf R., additional, Vieth, Michael, additional, Mangold, Elisabeth, additional, Gasenko, Evita, additional, Kupcinskas, Limas, additional, Brenner, Hermann, additional, Grimminger, Peter, additional, Bujanda, Luis, additional, Sopeña, Federico, additional, Espinel, Jesús, additional, Thomson, Concha, additional, Pérez-Aísa, Ángeles, additional, Campo, Rafael, additional, Geijo, Fernando, additional, Collette, Daniela, additional, Bruns, Christiane, additional, Messerle, Katharina, additional, Gockel, Ines, additional, Nöthen, Markus M., additional, Lippert, Hans, additional, Ridwelski, Karsten, additional, Lanas, Angel, additional, Keller, Gisela, additional, Knapp, Michael, additional, Leja, Marcis, additional, Kupcinskas, Juozas, additional, García-González, Maria A., additional, Venerito, Marino, additional, and Schumacher, Johannes, additional

Published
2018
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37. Relevance of DNA repair gene polymorphisms to gastric cancer risk and phenotype

Author

Carrera-Lasfuentes, Patricia, primary, Lanas, Angel, additional, Bujanda, Luis, additional, Strunk, Mark, additional, Quintero, Enrique, additional, Santolaria, Santos, additional, Benito, Rafael, additional, Sopeña, Federico, additional, Piazuelo, Elena, additional, Thomson, Concha, additional, Pérez-Aisa, Angeles, additional, Nicolás-Pérez, David, additional, Hijona, Elizabeth, additional, Espinel, Jesús, additional, Campo, Rafael, additional, Manzano, Marisa, additional, Geijo, Fernando, additional, Pellise, María, additional, Zaballa, Manuel, additional, González-Huix, Ferrán, additional, Espinós, Jorge, additional, Titó, Llúcia, additional, Barranco, Luis, additional, D'Amato, Mauro, additional, and García-González, María Asunción, additional

Published
2017
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38. 290 Relevance of DNA Repair Polymorphisms As Genetic Markers of Gastric Cancer Susceptibility and Prognosis in Caucasians

Author

García-González, Maria Asuncion, primary, Bujanda, Luis, additional, Quintero, Enrique, additional, Santolaria, Santos, additional, Benito, Rafael, additional, Strunk, Mark, additional, Sopena, Federico, additional, Thomson, Concepción, additional, Aisa, Angeles Perez, additional, Nicolás-Pérez, David, additional, Hijona, Elizabeth, additional, Carrera, Patricia, additional, Piazuelo, Elena, additional, Jimenez, Pilar, additional, Espinel, Jesus, additional, Campo, Rafael, additional, Manzano, Maria Luisa, additional, Geijo, Fernando, additional, Pellise, Maria, additional, Zaballa, Manuel, additional, González-Huix, Ferran, additional, Espinos, Jorge C., additional, Titó, LLúcia, additional, Barranco, Luis E., additional, Pazo-Cid, Roberto A., additional, and Lanas, Angel, additional

Published
2015
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39. Association ofPSCArs2294008 gene variants with poor prognosis and increased susceptibility to gastric cancer and decreased risk of duodenal ulcer disease

Author

García-González, María Asunción, primary, Bujanda, Luis, additional, Quintero, Enrique, additional, Santolaria, Santos, additional, Benito, Rafael, additional, Strunk, Mark, additional, Sopeña, Federico, additional, Thomson, Concha, additional, Pérez-Aisa, Angeles, additional, Nicolás-Pérez, David, additional, Hijona, Elizabeth, additional, Carrera-Lasfuentes, Patricia, additional, Piazuelo, Elena, additional, Jiménez, Pilar, additional, Espinel, Jesús, additional, Campo, Rafael, additional, Manzano, Marisa, additional, Geijo, Fernando, additional, Pellise, María, additional, Zaballa, Manuel, additional, González-Huix, Ferrán, additional, Espinós, Jorge, additional, Titó, Llúcia, additional, Barranco, Luis, additional, Pazo-Cid, Roberto, additional, and Lanas, Angel, additional

Published
2015
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40. Prognostic Role of Host Cyclooxygenase and Cytokine Genotypes in a Caucasian Cohort of Patients with Gastric Adenocarcinoma

Author

Medicina, Medikuntza, García-González, María Asunción, Nicolás-Pérez, David, Lanas, Ángel, Bujanda Fernández de Pierola, Luis, Carrera, Patricia, Benito, Rafael, Strunk, Mark, Sopeña, Federico, Santolaria, Santos, Piazuelo, Elena, Jiménez, Pilar, Campo, Rafael, Espinel, Jesús, Manzano, Marisa, Geijo, Fernando, Pellisé, María, González-Huix, Ferrán, Espinós, Jorge, Zaballa, Manuel, Titó, Llúcia, Barranco, Luis, Pazo, Roberto, Quintero, Enrique, Medicina, Medikuntza, García-González, María Asunción, Nicolás-Pérez, David, Lanas, Ángel, Bujanda Fernández de Pierola, Luis, Carrera, Patricia, Benito, Rafael, Strunk, Mark, Sopeña, Federico, Santolaria, Santos, Piazuelo, Elena, Jiménez, Pilar, Campo, Rafael, Espinel, Jesús, Manzano, Marisa, Geijo, Fernando, Pellisé, María, González-Huix, Ferrán, Espinós, Jorge, Zaballa, Manuel, Titó, Llúcia, Barranco, Luis, Pazo, Roberto, and Quintero, Enrique

Abstract

11 p., Background: Genetic factors influencing the prognosis of gastric adenocarcinoma (GAC) are not well known. Given the relevance of cytokines and other pro-inflammatory mediators in cancer progression and invasiveness, we aimed to assess the prognostic role of several functional cytokine and cyclooxygenase gene polymorphisms in patients with GAC. -- Methodology: Genomic DNA from 380 Spanish Caucasian patients with primary GAC was genotyped for 23 polymorphisms in pro-inflammatory (IL1B, TNFA, LTA, IL6, IL12p40), anti-inflammatory (IL4, IL1RN, IL10, TGFB1) cytokine, and cyclooxygenase (PTGS1 and PTGS2) genes by PCR, RFLP and TaqMan assays. Clinical and histological information was collected prospectively. Survival curves were estimated by the Kaplan-Meier method and compared using the log rank test. Outcome was determined by analysis of Cox proportional hazards, adjusting for confounding factors. -- Results: The median follow-up period and median overall survival (OS) time were 9.9 months (range 0.4-120.3) and 10.9 months (95% CI: 8.9-14.1), respectively. Multivariate analysis identified tumor stages III (HR, 3.23; 95% CI: 2-5.22) and IV (HR, 5.5; 95% CI: 3.51-8.63) as independent factors associated with a significantly reduced OS, whereas surgical treatment (HR: 0.44; 95% CI: 0.3-0.6) was related to a better prognosis of the disease. Concerning genetic factors, none of the 23 polymorphisms evaluated in the current study did influence survival. Moreover, no gene-environment interactions on GAC prognosis were observed. -- Conclusions: Our results show that, in our population, the panel of selected pro-and anti-inflammatory cytokine, and cyclooxygenase gene polymorphisms are not relevant in determining the prognosis of gastric adenocarcinoma.

Published
2012

41. Prognostic role of host cyclooxygenase and cytokine genotypes in a caucasian cohort of patients with gastric adenocarcinoma

Author

García-González, M. Asunción, Nicolás-Pérez, David, Lanas, Ángel, Bujanda, Luis, Carrera, Patricia, Benito, Rafael, Strunk, Mark, Sopeña, Federico, Santolaria, Santos, Piazuelo, Elena, Jiménez, Pilar, Campo, Rafael, Espinel, Jesús, Manzano, Marisa, Geijo, Fernando, Pellisé, María, González-Huix, Ferran, Espinós, Jorge, Zaballa, Manuel, Tito, Llucia, Barranco, Luis, Pazo, Roberto, Quintero, Enrique, García-González, M. Asunción, Nicolás-Pérez, David, Lanas, Ángel, Bujanda, Luis, Carrera, Patricia, Benito, Rafael, Strunk, Mark, Sopeña, Federico, Santolaria, Santos, Piazuelo, Elena, Jiménez, Pilar, Campo, Rafael, Espinel, Jesús, Manzano, Marisa, Geijo, Fernando, Pellisé, María, González-Huix, Ferran, Espinós, Jorge, Zaballa, Manuel, Tito, Llucia, Barranco, Luis, Pazo, Roberto, and Quintero, Enrique

Abstract

Background: Genetic factors influencing the prognosis of gastric adenocarcinoma (GAC) are not well known. Given the relevance of cytokines and other pro-inflammatory mediators in cancer progression and invasiveness, we aimed to assess the prognostic role of several functional cytokine and cyclooxygenase gene polymorphisms in patients with GAC. Methodology: Genomic DNA from 380 Spanish Caucasian patients with primary GAC was genotyped for 23 polymorphisms in pro-inflammatory (IL1B, TNFA, LTA, IL6, IL12p40), anti-inflammatory (IL4, IL1RN, IL10, TGFB1) cytokine, and cyclooxygenase (PTGS1 and PTGS2) genes by PCR, RFLP and TaqMan assays. Clinical and histological information was collected prospectively. Survival curves were estimated by the Kaplan-Meier method and compared using the log rank test. Outcome was determined by analysis of Cox proportional hazards, adjusting for confounding factors. Results: The median follow-up period and median overall survival (OS) time were 9.9 months (range 0.4-120.3) and 10.9 months (95% CI: 8.9-14.1), respectively. Multivariate analysis identified tumor stages III (HR, 3.23; 95% CI:2-5.22) and IV (HR, 5.5; 95% CI: 3.51-8.63) as independent factors associated with a significantly reduced OS, whereas surgical treatment (HR: 0.44; 95%CI: 0.3-0.6) was related to a better prognosis of the disease. Concerning genetic factors, none of the 23 polymorphisms evaluated in the current study did influence survival. Moreover, no gene-environment interactions on GAC prognosis were observed. Conclusions: Our results show that, in our population, the panel of selected pro- and anti-inflammatory cytokine, and cyclooxygenase gene polymorphisms are not relevant in determining the prognosis of gastric adenocarcinoma. © 2012 García-González et al.

Published
2012

42. Mo1122 Relevance of Psca Rs2294008 Gene Polymorphism on Gastric Cancer Risk and Prognosis

Author

Garcia-Gonzalez, Maria Asuncion, primary, Bujanda, Luis, additional, Quintero, Enrique, additional, Nicolás-Pérez, David, additional, Strunk, Mark, additional, Sopena, Federico, additional, Santolaria, Santos, additional, Thomson, Concepción, additional, Aisa, Angeles Perez, additional, Méndez-Sánchez, Isabel María, additional, Badia, Maria, additional, Hijona, Elizabeth, additional, Piazuelo, Elena, additional, Jimenez, Pilar, additional, Campo, Rafael, additional, Espinel, Jesus, additional, Manzano, Maria Luisa, additional, Geijo, Fernando, additional, Pellise, Maria, additional, Zaballa, Manuel, additional, González-Huix, Ferrán, additional, Espinos, Jorge C., additional, Barranco, Luis E., additional, Titó, LLúcia, additional, Pazo-Cid, Roberto A., additional, and Lanas, Angel, additional

Published
2013
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43. Prognostic Role of Host Cyclooxygenase and Cytokine Genotypes in a Caucasian Cohort of Patients with Gastric Adenocarcinoma

Author

García-González, María Asunción, primary, Nicolás-Pérez, David, additional, Lanas, Angel, additional, Bujanda, Luis, additional, Carrera, Patricia, additional, Benito, Rafael, additional, Strunk, Mark, additional, Sopeña, Federico, additional, Santolaria, Santos, additional, Piazuelo, Elena, additional, Jiménez, Pilar, additional, Campo, Rafael, additional, Espinel, Jesús, additional, Manzano, Marisa, additional, Geijo, Fernando, additional, Pellisé, María, additional, González-Huix, Ferrán, additional, Espinós, Jorge, additional, Zaballa, Manuel, additional, Titó, Llúcia, additional, Barranco, Luis, additional, Pazo, Roberto, additional, and Quintero, Enrique, additional

Published
2012
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44. Su1854 Association of TP53 Arg72pro Variants With Gastric Cancer Risk in Helicobacter pylori Infected Subjects: A Nation-Wide Case-Control Study in Spain

Author

Garcia-Gonzalez, Maria Asuncion, primary, Quintero, Enrique, additional, Bujanda, Luis, additional, Nicolás-Pérez, David, additional, Benito, Rafael, additional, Strunk, Mark, additional, Santolaria, Santos, additional, Sopena, Federico, additional, Badia, Maria, additional, Hijona, Elizabeth, additional, Thomson, Concepción, additional, Aisa, Angeles Perez, additional, Méndez-Sánchez, Isabel María, additional, Piazuelo, Elena, additional, Jimenez, Pilar, additional, Zaballa, Manuel, additional, Espinel, Jesus, additional, Geijo, Fernando, additional, Pellise, Maria, additional, Campo, Rafael, additional, Manzano, Marisa, additional, González-Huix, Ferrán, additional, Espinos, Jorge C., additional, Titó, LLúcia, additional, Cid, Roberto A. Pazo, additional, Barranco, Luis, additional, and Lanas, Angel, additional

Published
2012
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45. Relevance of DNA Repair Gene Polymorphisms on Gastric Cancer Susceptibility and Phenotype

Author

Garcia-Gonzalez, Maria Asuncion, primary, Quintero, Enrique, additional, Bujanda, Luis, additional, Nicolás-Pérez, David, additional, Benito, Rafael, additional, Strunk, Mark, additional, Santolaria, Santos, additional, Sopena, Federico, additional, Badia, Maria, additional, Piazuelo, Elena, additional, Jimenez, Pilar, additional, Espinel, Jesus, additional, Campo, Rafael, additional, Manzano, Marisa, additional, Geijo, Fernando, additional, Pellise, Maria, additional, González-Huix, Ferrán, additional, Espinós, Jorge C., additional, Titó, LLúcia, additional, Zaballa, Manuel, additional, Méndez-Sánchez, Isabel María, additional, Perez Aisa, Angeles, additional, Thomson, Concepción, additional, Pazo, Roberto, additional, and Lanas, Angel, additional

Published
2011
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46. Nones

Author

Geijo, Fernando. and Savater, Fernando 1947

Subjects
Savater, Fernando Entrevistas Artículos periodísticos
Published
1994

47. T2018 Innate Immunity and Gastric Cancer Susceptibility. Relevance of Helicobacter pylori Recognition-Related Genes on Gastric Cancer Risk

Author

Garcia-Gonzalez, Maria Asuncion, primary, Quintero, Enrique, additional, Nicolás-Pérez, David, additional, Benito, Rafael, additional, Strunk, Mark, additional, Santolaria, Santos, additional, Sopena, Federico, additional, Badia, Maria, additional, Piazuelo, Elena, additional, Jimenez, Pilar, additional, Espinel, Jesus, additional, Campo, Rafael, additional, Manzano, Marisa, additional, Geijo, Fernando, additional, Simón, Miguel A., additional, Pellise, Maria, additional, González-Huix, Ferrán, additional, Espinós, Jorge C., additional, Titó, LLúcia, additional, Bujanda, Luis, additional, Zaballa, Manuel, additional, Méndez-Sánchez, Isabel María, additional, Pérez-Aisa, María Angeles, additional, Thomson, Concepción, additional, and Lanas, Angel, additional

Published
2010
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48. W1884 Polymorphisms in Cytokine and Cyclooxygenase Genes Influence Long-Term Survival in Patients with Gastric Adenocarcinoma

Author

Nicolás-Pérez, David, primary, Quintero, Enrique, additional, Garcia-Gonzalez, Maria Asuncion, additional, Lanas, Angel, additional, Strunk, Mark, additional, Benito, Rafael, additional, Sopena, Federico, additional, Espinel, Jesús, additional, Campo, Rafael, additional, Santolaria, Santos, additional, Manzano, Marisa, additional, Bujanda, Luis, additional, Geijo, Fernando, additional, Pellise, Maria, additional, Simón, Miguel Angel, additional, González-Huix, Ferrán, additional, Espinós, Jorge C., additional, Priego, Luis Barranco, additional, Titó, LLúcia, additional, and Zaballa, Manuel, additional

Published
2009
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49. S1946 Relevance of GSTM1, GSTT1, and GSTP1 Gene Polymorphisms On Gastric Cancer Susceptibility

Author

Garcia-Gonzalez, Maria Asuncion, primary, Quintero, Enrique, additional, Benito, Rafael, additional, Strunk, Mark, additional, Nicolás-Pérez, David, additional, Parra-Blanco, Adolfo, additional, Santolaria, Santos, additional, Sopena, Federico, additional, Piazuelo, Elena, additional, Jimenez, Pilar, additional, Badia, Maria, additional, Espinel, Jesús, additional, Campo, Rafael, additional, Manzano, Marisa, additional, Geijo, Fernando, additional, Pellise, Maria, additional, González-Huix, Ferrán, additional, Nieto, Miguel, additional, Espinós, Jorge C., additional, Titó, LLúcia, additional, Bujanda, Luis, additional, Zaballa, Manuel, additional, Pérez-Aisa, María Angeles, additional, Méndez-Sánchez, Isabel María, additional, and Lanas, Angel, additional

Published
2009
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