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1. PLUS-IS-LESS project: Procalcitonin and Lung UltraSonography-based antibiotherapy in patients with Lower rESpiratory tract infection in Swiss Emergency Departments: study protocol for a pragmatic stepped-wedge cluster-randomized trial

Author

Bessat, Cécile, Bingisser, Roland, Schwendinger, Markus, Bulaty, Tim, Fournier, Yvan, Della Santa, Vincent, Pfeil, Magali, Schwab, Dominique, Leuppi, Jörg D., Geigy, Nicolas, Steuer, Stephan, Roos, Friedemann, Christ, Michael, Sirova, Adriana, Espejo, Tanguy, Riedel, Henk, Atzl, Alexandra, Napieralski, Fabian, Marti, Joachim, Cisco, Giulio, Foley, Rose-Anna, Schindler, Melinée, Hartley, Mary-Anne, Fayet, Aurélie, Garcia, Elena, Locatelli, Isabella, Albrich, Werner C., Hugli, Olivier, and Boillat-Blanco, Noémie

Published
2024
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3. Hyperacute T Wave in the Early Diagnosis of Acute Myocardial Infarction

Author

Meier, Mario, Troester, Valentina, Diebold, Matthias, Huber, Jeffrey, Baumgartner, Benjamin, Potlukova, Eliska, Hafner, Benjamin, Schoepfer, Hadrien, Buechi, Michael, Coscia, Tania, Geigy, Nicolas, Anwar, Mahnoor, Puelacher, Christian, du Fay de Lavallaz, Jeanne, Glarner, Noemi, Freese, Michael, Belkin, Maria, Lopez, Beatriz, Calderón, Sofia, Adrada, Esther Rodriguez, Morawiec, Beata, Munzyk, Piotr, von Eckardstein, Arnold, Campodarve, Isabel, Mitrovic, Sandra, Rentsch, Katharina, Buser, Andreas, Osswald, Stefan, Koechlin, Luca, Strebel, Ivo, Zimmermann, Tobias, Nestelberger, Thomas, Walter, Joan, Lopez-Ayala, Pedro, Boeddinghaus, Jasper, Shrestha, Samyut, Arslani, Ketina, Stefanelli, Sabrina, Reuthebuch, Benedikt, Wussler, Desiree, Ratmann, Paul David, Christ, Michael, Badertscher, Patrick, Wildi, Karin, Giménez, Maria Rubini, Gualandro, Danielle M., Miró, Òscar, Fuenzalida, Carolina, Martin-Sanchez, F. Javier, Kawecki, Damian, Bürgler, Franz, Keller, Dagmar I., Abächerli, Roger, Reuthebuch, Oliver, Eckstein, Friedrich S., Twerenbold, Raphael, Reichlin, Tobias, and Mueller, Christian

Published
2023
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4. Diagnostic discrimination of a novel high-sensitivity cardiac troponin I assay and derivation/validation of an assay-specific 0/1h-algorithm

Author

de Lavallaz, Jeanne du Fay, Walter, Joan Elias, Freese, Michael, Puelacher, Christian, Strebel, Ivo, Rentsch, Katharina, Mitrovic, Sandra, Gualandro, Danielle M., Schaerli, Nicolas, Sanchez, Ana Yufera, Okamura, Bernhard, Shrestha, Samyut, López, Beatriz, Martinez-Nadal, Gemma, Adrada, Esther Rodriguez, Parenica, Jiri, von Eckardstein, Arnold, Morawiec, Beata, Muzyk, Piotr, Koechlin, Luca, Boeddinghaus, Jasper, Lopez-Ayala, Pedro, Nestelberger, Thomas, Wussler, Desiree, Mais, Felix, Twerenbold, Raphael, Zimmermann, Tobias, Wildi, Karin, Köppen, Anne Marie, Miró, Òscar, Martin-Sanchez, F. Javier, Kawecki, Damian, Geigy, Nicolas, Keller, Dagmar I., Christ, Michael, Buser, Andreas, Giménez, Maria Rubini, Bernasconi, Luca, Hammerer-Lercher, Angelika, and Mueller, Christian

Published
2023
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5. Modification of the Emergency Severity Index Improves Mortality Prediction in Older Patients

Author

Malinovska, Alexandra, Pitasch, Laurentia, Geigy, Nicolas, Nickel, Christian H., and Bingisser, Roland

Subjects
Triage, Emergency Severity Index, Nonspecific Complaints, Geriatric
Abstract

Introduction: Older patients frequently present to the emergency department (ED) with nonspecific complaints (NSC), such as generalized weakness. They are at risk of adverse outcomes, and early risk stratification is crucial. Triage using Emergency Severity Index (ESI) is reliable and valid, but older patients are prone to undertriage, most often at decision point D. The aim of this study was to assess the predictive power of additional clinical parameters in NSC patients.Methods: Baseline demographics, vital signs, and deterioration of activity of daily living (ADL) in patients with NSC were prospectively assessed at four EDs. Physicians scored the coherence of history and their first impression. For prediction of 30-day mortality, we combined vital signs at decision point D (heart rate, respiratory rate, oxygen saturation) as “ESI vital,” and added “ADL deterioration,” “incoherence of history,” or “first impression,” using logistic regression models.Results: We included 948 patients with a median age of 81 years, 62% of whom were female. The baseline parameters at decision point D (ESI vital) showed an area under the curve (AUC) of 0.64 for predicting 30-day mortality in NSC patients. AUCs increased to 0.67 by adding ADL deterioration to 0.66 by adding incoherence of history, and to 0.71 by adding first impression. Maximal AUC was 0.73, combining all parameters.Conclusion: Adding the physicians’ first impressions to vital signs at decision point D increases predictive power of 30-day mortality significantly. Therefore, a modified ESI could improve predictive power of triage in older patients presenting with NSCs.

Published
2019

6. Performance of the American Heart Association/American College of Cardiology/Heart Rhythm Society versus European Society of Cardiology guideline criteria for hospital admission of patients with syncope

Author

Widmer, Velina, Leu, Kathrin, Reichlin, Tobias, Shrestha, Samyut, Freese, Michael, Krisai, Philipp, Belkin, Maria, Kawecki, Damian, Morawiec, Beata, Muzyk, Piotr, Nowalany-Kozielska, Ewa, Geigy, Nicolas, Martinez-Nadal, Gemma, Fuenzalida Inostroza, Carolina Isabel, Mandrión, José Bustamante, Poepping, Imke, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, Mitrovic, Sandra, von Eckardstein, Arnold, Buser, Andreas, Osswald, Stefan, Walter, Joan, Adler, David H., Bastani, Aveh, Baugh, Christopher W., Caterino, Jeffrey M., Diercks, Deborah B., Hollander, Judd E., Nicks, Bret A., Nishijima, Daniel K., Shah, Manish N., Stiffler, Kirk A., Wilber, Scott T., Storrow, Alan B., du Fay de Lavallaz, Jeanne, Zimmermann, Tobias, Badertscher, Patrick, Lopez-Ayala, Pedro, Nestelberger, Thomas, Miró, Òscar, Salgado, Emilio, Zaytseva, Xenia, Gafner, Michele Sara, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F. Javier, Di Somma, Salvatore, Peacock, W. Frank, Keller, Dagmar I., Costabel, Juan Pablo, Sigal, Alan, Puelacher, Christian, Wussler, Desiree, Koechlin, Luca, Strebel, Ivo, Schuler, Sereina, Manka, Robert, Bilici, Murat, Lohrmann, Jens, Kühne, Michael, Breidthardt, Tobias, Clark, Carol L., Probst, Marc, Gibson, Thomas A., Weiss, Robert E., Sun, Benjamin C., and Mueller, Christian

Published
2022
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7. Diagnostic and prognostic value of cardiac troponins in emergency department patients presenting after a fall: A prospective, multicenter study.

Author

Espejo, Tanguy, Terhalle, Lukas, Malinovska, Alexandra, Riedel, Henk B., Arntz, Laura, Hafner, Livia, Delport‐Lehnen, Karen, Zuppinger, Joanna, Geigy, Nicolas, Leuppi, Jörg, Somasundaram, Rajan, Bingisser, Roland, and Nickel, Christian H.

Subjects
MYOCARDIAL infarction diagnosis, MYOCARDIAL infarction, TROPONIN, HOSPITAL emergency services, DISEASE prevalence, DISCHARGE planning, DESCRIPTIVE statistics, LONGITUDINAL method, RESEARCH, MEDICAL care for older people, COMPARATIVE studies, ACCIDENTAL falls, BIOMARKERS, DISEASE incidence
Abstract

Background: Emergency department (ED) presentations after a ground‐level fall (GLF) are common. Falls were suggested to be another possible presenting feature of a myocardial infarction (MI), as unrecognized MIs are common in older adults. Elevated high‐sensitivity cardiac troponin (hs‐cTn) concentrations could help determine the etiology of a GLF in ED. We investigated the prevalence of both MI and elevated high‐sensitivity cardiac troponin T (hs‐cTnT) and I (hs‐cTnI), as well as the diagnostic accuracy of hs‐cTnT and hs‐cTnI regarding MI, and their prognostic value in older ED patients presenting after a GLF. Methods: This was a prospective, international, multicenter, cohort study with a follow‐up of up to 1 year. Patients aged 65 years or older presenting to the ED after a GLF were prospectively enrolled. Two outcome assessors independently reviewed all discharge records to ascertain final gold standard diagnoses. Hs‐cTnT and hs‐cTnI levels were determined from thawed samples for every patient. Results: In total, 558 patients were included. Median (IQR) age was 83 (77–89) years, and 67.7% were female. Elevated hs‐cTnT levels were found in 384 (68.8%) patients, and elevated hs‐cTnI levels in 86 (15.4%) patients. Three patients (0.5%) were ascertained the gold standard diagnosis MI. Within 30 days, 18 (3.2%) patients had died. Nonsurvivors had higher hs‐cTnT and hs‐cTnI levels compared with survivors (hs‐cTnT 40 [23–85] ng/L in nonsurvivors and 20 [13–33] ng/L in survivors; hs‐cTnI 25 [14–54] ng/L in nonsurvivors and 8 [4–16] ng/L in survivors; p < 0.001 for both). Conclusions: A majority of patients (n = 364, 68.8%) presenting to the ED after a fall had elevated hs‐cTnT levels and 86 (15.4%) elevated hs‐cTnI levels. However, the incidence of MI in these patients was low (n = 3, 0.5%). Our data do not support the opinion that falls may be a common presenting feature of MI. We discourage routine troponin testing in this population. However, hs‐cTnT and hs‐cTnI were both found to have prognostic properties for mortality prediction up to 1 year. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Predicting Major Adverse Events in Patients With Acute Myocardial Infarction

Author

Hafner, Benjamin, Flores, Dayana, Meissner, Kathrin, Kulangara, Caroline, Freese, Michael, Osswald, Stefan, Stelzig, Claudia, Bingisser, Roland, Fuenzalida Inostroza, Carolina Isabel, Rodríguez Adrada, Esther, Nowalany-Kozielska, Ewa, Kawecki, Damian, Parenica, Jiri, Ganovská, Eva, Lohrmann, Jens, Amrein, Melissa, Steude, Jana, Buser, Andreas, Grimm, Karin, Hartmann, Beate, Morawiec, Beata, Rentsch, Katharina, von Eckardstein, Arnold, Biskup, Ewalina, Campodarve, Isabel, Gea, Joachim, Nestelberger, Thomas, Boeddinghaus, Jasper, Wussler, Desiree, Twerenbold, Raphael, Badertscher, Patrick, Wildi, Karin, Miró, Òscar, López, Beatriz, Martin-Sanchez, F. Javier, Muzyk, Piotr, Koechlin, Luca, Baumgartner, Benjamin, Meier, Mario, Troester, Valentina, Rubini Giménez, Maria, Puelacher, Christian, du Fay de Lavallaz, Jeanne, Walter, Joan, Kozhuharov, Nikola, Zimmermann, Tobias, Gualandro, Danielle M., Michou, Eleni, Potlukova, Eliska, Geigy, Nicolas, Keller, Dagmar I., Reichlin, Tobias, and Mueller, Christian

Published
2019
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9. Prevalence of Pulmonary Embolism in Patients With Syncope

Author

Rubini Giménez, Maria, Kozhuharov, Nikola, Shrestha, Samyut, Sazgary, Lorraine, Morawiec, Beata, Muzyk, Piotr, Nowalany-Kozielska, Ewa, Bustamante Mandrión, José, Poepping, Imke, Freese, Michael, Meissner, Kathrin, Kulangara, Caroline, Fuenzalida Inostroza, Carolina Isabel, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, von Eckardstein, Arnold, Buser, Andreas, Kloos, Wanda, Steude, Jana, Osswald, Stefan, Badertscher, Patrick, du Fay de Lavallaz, Jeanne, Hammerer-Lercher, Angelika, Nestelberger, Thomas, Zimmermann, Tobias, Geiger, Marc, Imahorn, Orell, Miró, Òscar, Salgado, Emilio, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F. Javier, Di Somma, Salvatore, Peacock, W. Frank, Keller, Dagmar I., Costabel, Juan Pablo, Walter, Joan, Boeddinghaus, Jasper, Twerenbold, Raphael, Méndez, Adriana, Gospodinov, Boris, Puelacher, Christian, Wussler, Desiree, Koechlin, Luca, Kawecki, Damian, Geigy, Nicolas, Strebel, Ivo, Lohrmann, Jens, Kühne, Michael, Reichlin, Tobias, and Mueller, Christian

Published
2019
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10. External validation of the myocardial-ischaemic-injury-index machine learning algorithm for the early diagnosis of myocardial infarction: a multicentre cohort study

Author

Lopez-Ayala, Pedro, Boeddinghaus, Jasper, Nestelberger, Thomas, Koechlin, Luca, Zimmermann, Tobias, Bima, Paolo, Glaeser, Jonas, Spagnuolo, Carlos C, Champetier, Arnaud, Miro, Oscar, Martin-Sanchez, Francisco Javier, Keller, Dagmar I, Christ, Michael, Wildi, Karin, Breidthardt, Tobias, Strebel, Ivo, Mueller, Christian, Reichlin, Tobias, Kaeslin, Marina, Potlukova, Eliska, Kawecki, Damian, Geigy, Nicolas, Rentsch, Katharina, Shrestha, Samyut, Guzman-Tacla, Caroline A., Herraiz-Recuenco, Lourdes, Morawiec, Beata, Munzk, Piotr, Freese, Michael, Martinez-Nadal, Gemma, Fuenzalida, Carolina, Calderon, Sofia, Rodriguez Adrada, Esther, Ganovská, Eva, Parenica, Jiri, von Eckardstein, Arnold, Campodarve, Isabel, and Gea, Joachim

Abstract

The myocardial-ischaemic-injury-index (MI3) is a novel machine learning algorithm for the early diagnosis of type 1 non-ST-segment elevation myocardial infarction (NSTEMI). The performance of MI3, both when using early serial blood draws (eg, at 1 h or 2 h) and in direct comparison with guideline-recommended algorithms, remains unknown. Our aim was to externally validate MI3and compare its performance with that of the European Society of Cardiology (ESC) 0/1h-algorithm.

Published
2024
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11. Prospective validation of prognostic and diagnostic syncope scores in the emergency department

Author

du Fay de Lavallaz, Jeanne, Badertscher, Patrick, Nestelberger, Thomas, Isenrich, Rahel, Miró, Òscar, Salgado, Emilio, Geigy, Nicolas, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F. Javier, Bustamante Mandrión, José, Di Somma, Salvatore, Peacock, W. Frank, Kawecki, Damian, Boeddinghaus, Jasper, Twerenbold, Raphael, Puelacher, Christian, Wussler, Desiree, Strebel, Ivo, Keller, Dagmar I., Poepping, Imke, Kühne, Michael, Mueller, Christian, Reichlin, Tobias, Giménez, Maria Rubini, Walter, Joan, Kozhuharov, Nikola, Shrestha, Samyut, Mueller, Deborah, Sazgary, Lorraine, Morawiec, Beata, Muzyk, Piotr, Nowalany-Kozielska, Ewa, Freese, Michael, Stelzig, Claudia, Meissner, Kathrin, Kulangara, Caroline, Hartmann, Beate, Ferel, Ina, Sabti, Zaid, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, von Eckardstein, Arnold, Buser, Andreas, Kloos, Wanda, Lohrmann, Jens, and Osswald, Stefan

Published
2018
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12. Prospective Validation of the 0/1-h Algorithm for Early Diagnosis of Myocardial Infarction

Author

Twerenbold, Raphael, Neumann, Johannes Tobias, Sörensen, Nils Arne, Ojeda, Francisco, Karakas, Mahir, Boeddinghaus, Jasper, Nestelberger, Thomas, Badertscher, Patrick, Rubini Giménez, Maria, Puelacher, Christian, Wildi, Karin, Kozhuharov, Nikola, Breitenbuecher, Dominik, Biskup, Ewelina, du Fay de Lavallaz, Jeanne, Flores, Dayana, Wussler, Desiree, Miró, Òscar, Martín Sánchez, F. Javier, Morawiec, Beata, Parenica, Jiri, Geigy, Nicolas, Keller, Dagmar I., Zeller, Tanja, Reichlin, Tobias, Blankenberg, Stefan, Westermann, Dirk, and Mueller, Christian

Published
2018
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13. Hyperacute T Wave in the Early Diagnosis of Acute Myocardial Infarction

Author

Koechlin, Luca, primary, Strebel, Ivo, additional, Zimmermann, Tobias, additional, Nestelberger, Thomas, additional, Walter, Joan, additional, Lopez-Ayala, Pedro, additional, Boeddinghaus, Jasper, additional, Shrestha, Samyut, additional, Arslani, Ketina, additional, Stefanelli, Sabrina, additional, Reuthebuch, Benedikt, additional, Wussler, Desiree, additional, Ratmann, Paul David, additional, Christ, Michael, additional, Badertscher, Patrick, additional, Wildi, Karin, additional, Giménez, Maria Rubini, additional, Gualandro, Danielle M., additional, Miró, Òscar, additional, Fuenzalida, Carolina, additional, Martin-Sanchez, F. Javier, additional, Kawecki, Damian, additional, Bürgler, Franz, additional, Keller, Dagmar I., additional, Abächerli, Roger, additional, Reuthebuch, Oliver, additional, Eckstein, Friedrich S., additional, Twerenbold, Raphael, additional, Reichlin, Tobias, additional, Mueller, Christian, additional, Meier, Mario, additional, Troester, Valentina, additional, Diebold, Matthias, additional, Huber, Jeffrey, additional, Baumgartner, Benjamin, additional, Potlukova, Eliska, additional, Hafner, Benjamin, additional, Schoepfer, Hadrien, additional, Buechi, Michael, additional, Coscia, Tania, additional, Geigy, Nicolas, additional, Anwar, Mahnoor, additional, Puelacher, Christian, additional, du Fay de Lavallaz, Jeanne, additional, Glarner, Noemi, additional, Freese, Michael, additional, Belkin, Maria, additional, Lopez, Beatriz, additional, Calderón, Sofia, additional, Adrada, Esther Rodriguez, additional, Morawiec, Beata, additional, Munzyk, Piotr, additional, von Eckardstein, Arnold, additional, Campodarve, Isabel, additional, Mitrovic, Sandra, additional, Rentsch, Katharina, additional, Buser, Andreas, additional, and Osswald, Stefan, additional

Published
2023
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14. Diagnostic discrimination of a novel high-sensitivity cardiac troponin I assay and derivation/validation of an assay-specific 0/1h-algorithm

Author

Koechlin, Luca, Boeddinghaus, Jasper, Lopez-Ayala, Pedro, Nestelberger, Thomas, Wussler, Desiree, Mais, Felix, Twerenbold, Raphael, Zimmermann, Tobias, Wildi, Karin, Köppen, Anne Marie, Miró, Òscar, Martin-Sanchez, F Javier, Kawecki, Damian, Geigy, Nicolas, Keller, Dagmar I, Christ, Michael, Buser, Andreas, Giménez, Maria Rubini, Bernasconi, Luca, Hammerer-Lercher, Angelika, Mueller, Christian, APACE Investigators, Koechlin, Luca, Boeddinghaus, Jasper, Lopez-Ayala, Pedro, Nestelberger, Thomas, Wussler, Desiree, Mais, Felix, Twerenbold, Raphael, Zimmermann, Tobias, Wildi, Karin, Köppen, Anne Marie, Miró, Òscar, Martin-Sanchez, F Javier, Kawecki, Damian, Geigy, Nicolas, Keller, Dagmar I, Christ, Michael, Buser, Andreas, Giménez, Maria Rubini, Bernasconi, Luca, Hammerer-Lercher, Angelika, Mueller, Christian, and APACE Investigators

Abstract

BACKGROUND We aimed to assess the diagnostic utility of the Dimension EXL LOCI High-Sensitivity Troponin I (hs-cTnI-EXL) assay. METHODS This multicenter study included patients with chest discomfort presenting to the emergency department. Diagnoses were centrally and independently adjudicated by two cardiologists using all available clinical information. Adjudication was performed twice including serial measurements of high-sensitivity cardiac troponin (hs-cTn) I-Architect (primary analysis) and serial measurements of hs-cTnT-Elecsys (secondary analysis) in addition to the clinically used (hs)-cTn. The primary objective was to assess and compare the discriminatory performance of hs-cTnI-EXL, hs-cTnI-Architect and hs-cTnT-Elecsys for acute myocardial infarction (MI). Furthermore, we derived and validated a hs-cTnI-EXL-specific 0/1h-algorithm. RESULTS Adjudicated MI was the diagnosis in 204/1454 (14%) patients. The area under the receiver operating characteristics curve for hs-cTnI-EXL was 0.94 (95%CI, 0.93-0.96), and comparable to hs-cTnI-Architect (0.95; 95%CI, 0.93-0.96) and hs-cTnT-Elecsys (0.93; 95%CI, 0.91-0.95). In the derivation cohort (n = 813), optimal criteria for rule-out of MI were <9ng/L at presentation (if chest pain onset >3h) or <9ng/L and 0h-1h-change <5ng/L, and for rule-in ≥160ng/L at presentation or 0h-1h-change ≥100ng/L. In the validation cohort (n = 345), these cut-offs ruled-out 56% of patients (negative predictive value 99.5% (95%CI, 97.1-99.9), sensitivity 97.8% (95%CI, 88.7-99.6)), and ruled-in 9% (positive predictive value 83.3% (95%CI, 66.4-92.7), specificity 98.3% (95%CI, 96.1-99.3)). Secondary analyses using adjudication based on hs-cTnT measurements confirmed the findings. CONCLUSIONS The overall performance of the hs-cTnI-EXL was comparable to best-validated hs-cTnT/I assays and an assay-specific 0/1h-algorithm safely rules out and accurately rules in acute MI. CLINICAL TRIAL REGISTRATION ClinicalTrials.gov number, NCT00470587.

Published
2023

15. Diagnostic discrimination of a novel high-sensitivity cardiac troponin I assay and derivation/validation of an assay-specific 0/1h-algorithm

Author

Koechlin, Luca, primary, Boeddinghaus, Jasper, additional, Lopez-Ayala, Pedro, additional, Nestelberger, Thomas, additional, Wussler, Desiree, additional, Mais, Felix, additional, Twerenbold, Raphael, additional, Zimmermann, Tobias, additional, Wildi, Karin, additional, Köppen, Anne Marie, additional, Miró, Òscar, additional, Martin-Sanchez, F. Javier, additional, Kawecki, Damian, additional, Geigy, Nicolas, additional, Keller, Dagmar I., additional, Christ, Michael, additional, Buser, Andreas, additional, Giménez, Maria Rubini, additional, Bernasconi, Luca, additional, Hammerer-Lercher, Angelika, additional, Mueller, Christian, additional, de Lavallaz, Jeanne du Fay, additional, Walter, Joan Elias, additional, Freese, Michael, additional, Puelacher, Christian, additional, Strebel, Ivo, additional, Rentsch, Katharina, additional, Mitrovic, Sandra, additional, Gualandro, Danielle M., additional, Schaerli, Nicolas, additional, Sanchez, Ana Yufera, additional, Okamura, Bernhard, additional, Shrestha, Samyut, additional, López, Beatriz, additional, Martinez-Nadal, Gemma, additional, Adrada, Esther Rodriguez, additional, Parenica, Jiri, additional, von Eckardstein, Arnold, additional, Morawiec, Beata, additional, and Muzyk, Piotr, additional

Published
2023
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17. Direct Comparison of the 0/1h and 0/3h Algorithms for Early Rule-Out of Acute Myocardial Infarction

Author

Badertscher, Patrick, Boeddinghaus, Jasper, Twerenbold, Raphael, Nestelberger, Thomas, Wildi, Karin, Wussler, Desiree, Schwarz, Jonas, Puelacher, Christian, Rubini Giménez, Maria, Kozhuharov, Nikola, du Fay de Lavallaz, Jeanne, Cerminara, Sara Elisa, Potlukova, Eliska, Rentsch, Katharina, Miró, Òscar, López, Beatriz, Martin-Sanchez, F. Javier, Morawiec, Beata, Muzyk, Piotr, Keller, Dagmar I., Reichlin, Tobias, Mueller, Christian, Sabti, Zaid, Strebel, Ivo, Shrestha, Samyut, Flores, Dayana, Freese, Michael, Stelzig, Claudia, Kulangara, Caroline, Meissner, Kathrin, Schaerli, Nicolas, Mueller, Deborah, Yufera Sanchez, Ana, Sazgary, Lorraine, Marbot, Stella, Fuenzalida, Carolina, Calderón, Sofia, Rodriguez Adrada, Esther, Kawecki, Damian, Nowalany-Kozielska, Ewa, Parenica, Jiri, Ganovská, Eva, von Eckardstein, Arnold, Lohrmann, Jens, Kloos, Wanda, Osswald, Stefan, Buser, Andreas, Bingisser, Roland, and Geigy, Nicolas

Published
2018
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18. 0/1-Hour Triage Algorithm for Myocardial Infarction in Patients With Renal Dysfunction

Author

Twerenbold, Raphael, Badertscher, Patrick, Boeddinghaus, Jasper, Nestelberger, Thomas, Wildi, Karin, Puelacher, Christian, Sabti, Zaid, Rubini Gimenez, Maria, Tschirky, Sandra, du Fay de Lavallaz, Jeanne, Kozhuharov, Nikola, Sazgary, Lorraine, Mueller, Deborah, Breidthardt, Tobias, Strebel, Ivo, Flores Widmer, Dayana, Shrestha, Samyut, Miró, Òscar, Martín-Sánchez, F. Javier, Morawiec, Beata, Parenica, Jiri, Geigy, Nicolas, Keller, Dagmar I., Rentsch, Katharina, von Eckardstein, Arnold, Osswald, Stefan, Reichlin, Tobias, and Mueller, Christian

Published
2018
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19. Direct Comparison of 4 Very Early Rule-Out Strategies for Acute Myocardial Infarction Using High-Sensitivity Cardiac Troponin I

Author

Boeddinghaus, Jasper, Nestelberger, Thomas, Twerenbold, Raphael, Wildi, Karin, Badertscher, Patrick, Cupa, Janosch, Bürge, Tobias, Mächler, Patrick, Corbière, Sydney, Grimm, Karin, Giménez, Maria Rubini, Puelacher, Christian, Shrestha, Samyut, Flores Widmer, Dayana, Fuhrmann, Jakob, Hillinger, Petra, Sabti, Zaid, Honegger, Ursina, Schaerli, Nicolas, Kozhuharov, Nikola, Rentsch, Katharina, Miró, Òscar, López, Beatriz, Martin-Sanchez, F. Javier, Rodriguez-Adrada, Esther, Morawiec, Beata, Kawecki, Damian, Ganovská, Eva, Parenica, Jiri, Lohrmann, Jens, Kloos, Wanda, Buser, Andreas, Geigy, Nicolas, Keller, Dagmar I., Osswald, Stefan, Reichlin, Tobias, and Mueller, Christian

Published
2017
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20. Audit of Asthma Exacerbation Management in a Swiss General Hospital.

Author

Schnyder, Dominik, Lüthi-Corridori, Giorgia, Leuppi-Taegtmeyer, Anne Barbara, Boesing, Maria, Geigy, Nicolas, and Leuppi, Joerg Daniel

Subjects
THERAPEUTIC use of glucocorticoids, ASTHMA prevention, AUDITING, HOSPITALS, ADRENERGIC beta agonists, SCIENTIFIC observation, PARASYMPATHOMIMETIC agents, COMBINATION drug therapy, RETROSPECTIVE studies, OXYGEN saturation, MEDICAL protocols, BRONCHODILATOR agents, HEART beat, DESCRIPTIVE statistics, INHALATION administration, DISEASE exacerbation, LONGITUDINAL method
Abstract

Background: Adequate management is crucial to reduce symptoms, hospitalization, and relapses in patients with asthma. Hospitals often struggle to meet treatment guidelines, and no recent data for Switzerland are available. Objectives: The aim of the study was to audit the asthma exacerbation management in the Cantonal Hospital of Baselland in order to evaluate the level of compliance with guidelines in a narrative discussion. Method: The study design is a retrospective observational cohort study. We evaluated all adult patients presenting to the hospital with a physician-diagnosed asthma exacerbation in 2018 and 2019. The asthma management patients received was compared to the Swiss guidelines and the international GINA guidelines. Results: 160 patients were included (mean age: 50 years old, 57.5% female). SpO2 and heart rate were assessed at presentation in nearly all patients. Peak expiratory flow (PEF) was measured in only 14%. Adequate management of asthma exacerbation with inhaled bronchodilator medication in a combination of short-acting beta-agonists and short-acting anticholinergics was administered to 96% of the patients. Patients with severe symptoms received systemic glucocorticosteroids within 6 h in 55%. At discharge, a reliever medication was prescribed for 64% of the patients and 55% received a new or increased controller therapy with inhaled glucocorticosteroid (ICS). 49% of the patients had no follow-up organized. Conclusion: To increase the guideline conformity and quality of asthma exacerbation management, the severity should be better assessed, especially by routinely performing PEF measurements. Treatment needs to be intensified; in particular, the ICS dose should be increased significantly and systemic glucocorticosteroids should be given with a lower threshold. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Performance of the ESC 0/2h-algorithm using high-sensitivity cardiac troponin I in the early diagnosis of myocardial infarction

Author

Zimmermann, Tobias, Reichlin, Tobias, Christ, Michael, Puelacher, Christian, de Lavallaz, Jeanne du Fay, Potlukova, Eliska, Diebold, Matthias, Kawecki, Damian, Geigy, Nicolas, Rentsch, Katharina, Mitrovic, Sandra, Fuenzalida, Carolina, Glarner, Noemi, Morawiec, Beata, Munzk, Piotr, Breidthardt, Tobias, Freese, Michael, López, Beatriz, Calderón, Sofia, Adrada, Esther Rodriguez, Ganovská, Eva, Parenica, Jiri, von Eckardstein, Arnold, Campodarve, Isabel, Gea, Joaquim, Koechlin, Luca, Boeddinghaus, Jasper, Nestelberger, Thomas, Lopez-Ayala, Pedro, Wussler, Desiree, Shrestha, Samyut, Resa, Tobias, Wildi, Karin, Bakula, Adam, Frey, Simon, Miró, Òscar, Martin-Sanchez, F Javier, Strebel, Ivo, Gualandro, Danielle M, Eckstein, Friedrich S, Reuthebuch, Oliver, Keller, Dagmar I, Twerenbold, Raphael, Giménez, Maria Rubini, and Mueller, Christian

Published
2021
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22. Performance of the ESC 0/2h-algorithm using high-sensitivity cardiac troponin I in the early diagnosis of myocardial infarction

Author

Koechlin, Luca, primary, Boeddinghaus, Jasper, additional, Nestelberger, Thomas, additional, Lopez-Ayala, Pedro, additional, Wussler, Desiree, additional, Shrestha, Samyut, additional, Resa, Tobias, additional, Wildi, Karin, additional, Bakula, Adam, additional, Frey, Simon, additional, Miró, Òscar, additional, Martin-Sanchez, F Javier, additional, Strebel, Ivo, additional, Gualandro, Danielle M, additional, Eckstein, Friedrich S, additional, Reuthebuch, Oliver, additional, Keller, Dagmar I, additional, Twerenbold, Raphael, additional, Giménez, Maria Rubini, additional, Mueller, Christian, additional, Zimmermann, Tobias, additional, Reichlin, Tobias, additional, Christ, Michael, additional, Puelacher, Christian, additional, de Lavallaz, Jeanne du Fay, additional, Potlukova, Eliska, additional, Diebold, Matthias, additional, Kawecki, Damian, additional, Geigy, Nicolas, additional, Rentsch, Katharina, additional, Mitrovic, Sandra, additional, Fuenzalida, Carolina, additional, Glarner, Noemi, additional, Morawiec, Beata, additional, Munzk, Piotr, additional, Breidthardt, Tobias, additional, Freese, Michael, additional, López, Beatriz, additional, Calderón, Sofia, additional, Adrada, Esther Rodriguez, additional, Ganovská, Eva, additional, Parenica, Jiri, additional, von Eckardstein, Arnold, additional, Campodarve, Isabel, additional, and Gea, Joaquim, additional

Published
2021
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23. Utility of Echocardiography in Patients With Suspected Acute Myocardial Infarction and Left Bundle‐Branch Block

Author

Nestelberger, Thomas, primary, Boeddinghaus, Jasper, additional, Lopez Ayala, Pedro, additional, Gehrke, Juliane, additional, Twerenbold, Raphael, additional, Cullen, Louise, additional, Mueller, Christian, additional, Strebel, Ivo, additional, Prepoudis, Alexandra, additional, Gualandro, Danielle M., additional, Puelacher, Christian, additional, du Fay Lavallaz, Jeanne, additional, Frey, Simon Martin, additional, Ratmann, Paul David, additional, Arslani, Ketina, additional, Walter, Joan Elias, additional, Freese, Michael, additional, Shrestha, Samyut, additional, Belkin, Maria, additional, Koechlin, Luca, additional, Hillinger, Petra, additional, Potlukova, Eliska, additional, Rentsch, Katharina, additional, Mitrovic, Sandra, additional, Kawecki, Damian, additional, Morawiec, Beata, additional, Munzk, Piotr, additional, Geigy, Nicolas, additional, Reichlin, Tobias, additional, Martinez‐Nadal, Gemma, additional, Fuenzalida Inostroza, Carolina Isabel, additional, Miró, Òscar, additional, Mandrión, José Bustamante, additional, Martín‐Sánchez, Javier, additional, von Eckardstein, Arnold, additional, Buser, Andreas, additional, Greenslade, Jaimi, additional, Christ, Michael, additional, Giannitsis, Evangelos, additional, and Lindahl, Bertil, additional

Published
2021
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24. Novel Criteria for the Observe-Zone of the ESC 0/1h-hs-cTnT Algorithm

Author

Lopez-Ayala, Pedro, primary, Nestelberger, Thomas, additional, Boeddinghaus, Jasper, additional, Koechlin, Luca, additional, Ratmann, Paul David, additional, Strebel, Ivo, additional, Gehrke, Juliane, additional, Meier, Severin, additional, Walter, Joan, additional, Rubini Gimenez, Maria, additional, Mutschler, Eugenio, additional, Miró, Òscar, additional, López-Barbeito, Beatriz, additional, Martín-Sánchez, Francisco Javier, additional, Rodríguez-Adrada, Esther, additional, Keller, Dagmar I., additional, Newby, L. Kristin, additional, Twerenbold, Raphael, additional, Giannitsis, Evangelos, additional, Lindahl, Bertil, additional, Mueller, Christian, additional, Zimmermann, Tobias, additional, Schoepfer, Hadrien, additional, Coscia, Tania, additional, Troester, Valentina, additional, Reichlin, Tobias, additional, Kaeslin, Marina, additional, Christ, Michael, additional, Meier, Mario, additional, Badertscher, Patrick, additional, Puelacher, Christian, additional, du Fay de Lavallaz, Jeanne, additional, Potlukova, Eliska, additional, Kawecki, Damian, additional, Geigy, Nicolas, additional, Rentsch, Katharina, additional, Shrestha, Samyut, additional, Morawiec, Beata, additional, Munzk, Piotr, additional, Breidthardt, Tobias, additional, Freese, Michael, additional, Martinez-Nadal, Gemma, additional, Fuenzalida, Carolina, additional, Calderón, Sofia, additional, Rodriguez Adrada, Esther, additional, Ganovská, Eva, additional, Parenica, Jiri, additional, von Eckardstein, Arnold, additional, Campodarve, Isabel, additional, Gea, Joachim, additional, Mccord, James, additional, Nowak, Richard, additional, Body, Richard, additional, deFilippi, Christopher R., additional, Christenson, Robert H., additional, Panteghini, Mauro, additional, Plebani, Mario, additional, Verschuren, Franck, additional, French, John, additional, Weiser, Silvia, additional, and Jernberg, Tomas, additional

Published
2021
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25. Sex-Specific Chest Pain Characteristics in the Early Diagnosis of Acute Myocardial Infarction

Author

Gimenez, Maria Rubini, Reiter, Miriam, Twerenbold, Raphael, Reichlin, Tobias, Wildi, Karin, Haaf, Philip, Wicki, Katharina, Zellweger, Christa, Hoeller, Rebeca, Moehring, Berit, Sou, Seoung Mann, Mueller, Mira, Denhaerynck, Kris, Meller, Bernadette, Stallone, Fabio, Henseler, Sarah, Bassetti, Stefano, Geigy, Nicolas, Osswald, Stefan, and Mueller, Christian

Published
2014
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26. External Validation of the No Objective Testing Rules in Acute Chest Pain

Author

Ratmann, Paul David, primary, Boeddinghaus, Jasper, additional, Nestelberger, Thomas, additional, Lopez‐Ayala, Pedro, additional, Koechlin, Luca, additional, Wildi, Karin, additional, Miro, Oscar, additional, Martín‐Sánchez, F. Javier, additional, Christ, Michael, additional, Twerenbold, Raphael, additional, Rubini Gimenez, Maria, additional, Keller, Dagmar I., additional, Mueller, Christian, additional, Troester, Valentina, additional, Meier, Mario, additional, Puelacher, Christian, additional, du Fay de Lavallaz, Jeanne, additional, Potlukova, Eliska, additional, Badertscher, Patrick, additional, Arslani, Ketina, additional, Freese, Michael, additional, Michou, Eleni, additional, Flores, Dayana, additional, Lohrmann, Jens, additional, Rentsch, Katharina, additional, Reichlin, Tobias, additional, López, Beatriz, additional, Fuenzalida, Carolina, additional, Rodriguez Adrada, Esther, additional, Ganovská, Eva, additional, Parenica, Jiri, additional, von Eckardstein, Arnold, additional, Morawiec, Beata, additional, Kawecki, Damian, additional, Muzyk, Piotr, additional, Bürgler, Franz, additional, and Geigy, Nicolas, additional

Published
2021
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27. Clinical Utility of D-Dimer for Rule-Out or Rule-In of Venous Thromboembolism in Syncope.

Author

Badertscher, Patrick, du Fay de Lavallaz, Jeanne, Hammerer-Lercher, Angelika, Mueller, Christian, Zimmermann, Tobias, Lopez-Ayala, Pedro, Nestelberger, Thomas, Gualandro, Danielle M., Miró, Òscar, Keller, Dagmar I., Martin-Sanchez, F. Javier, Bürgler, Franz, Than, Martin, Widmer, Velina, Christ, Michael, Cullen, Louise, Di Somma, Salvatore, Peacock, W. Frank, Geigy, Nicolas, and Kühne, Michael

Abstract

Fig. 1 Diagnostic performance of D-dimer using two different assays in patients presenting with syncope. A Left: Receiver-operating characteristic curves quantifying the diagnostic performance of Innovance® D-dimer (blue) and hs-Loci-Innovance® D-dimer (red) for the diagnosis of venous thromboembolism (VTE). Right: Clinical application of D-dimer using the 2-level Wells-score with age-adjusted1 or fixed cutoffs versus the YEARS-algorithm with probability-adjusted cut offs2. B Left: Specificity for different cufoffs of Innovance® D-dimer (blue) and hs-Loci-Innovance® D-dimer (red) for the diagnosis of venous thromboembolism (VTE). Right: Percentage of patients ruled-in and correctly identified VTE patients for different cutoffs of Innovance® D-dimer (blue) and hs-Loci-Innovance® D-dimer (red). 1In patients 50 years or younger, D-dimer concentration < 0.5 mg/l was considered negative. For patients older than 50 years, we used the formula: age in years divided by 100. 2YEARS-algorithm: assessment of only three items from the Wells-score (clinical signs of deep vein thrombosis, hemoptysis, pulmonary embolism the most likely diagnosis) and using a D-dimer test threshold of 0.5 mg/l in presence, and 1.0 mg/l in absence of one of the YEARS-items [ABSTRACT FROM AUTHOR]

Published
2023
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28. Development of an electrocardiogram-based risk calculator for a cardiac cause of syncope

Author

Zimmermann, Tobias, primary, du Fay de Lavallaz, Jeanne, additional, Walter, Joan Elias, additional, Strebel, Ivo, additional, Nestelberger, Thomas, additional, Joray, Lydia, additional, Badertscher, Patrick, additional, Flores, Dayana, additional, Widmer, Velina, additional, Geigy, Nicolas, additional, Miro, Oscar, additional, Salgado, Emilio, additional, Christ, Michael, additional, Cullen, Louise, additional, Than, Martin, additional, Martín-Sánchez, Francisco Javier, additional, Di Somma, Salvatore, additional, Peacock, W Frank, additional, Keller, Dagmar, additional, Costabel, Juan Pablo, additional, Wussler, Desiree Nadine, additional, Kawecki, Damian, additional, Lohrmann, Jens, additional, Gualandro, Danielle Menosi, additional, Kuehne, Michael, additional, Reichlin, Tobias, additional, Sun, Benjamin, additional, and Mueller, Christian, additional

Published
2021
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29. Association of Previous Myocardial Infarction and Time to Presentation With Suspected Acute Myocardial Infarction

Author

Troester, Valentina, primary, Strebel, Ivo, additional, Nestelberger, Thomas, additional, Boeddinghaus, Jasper, additional, Rubini Gimenez, Maria, additional, Lopez‐Ayala, Pedro, additional, Koechlin, Luca, additional, Glarner, Noemi, additional, Prepoudis, Alexandra, additional, Miró, Òscar, additional, Martin‐Sanchez, F. Javier, additional, Kawecki, Damian, additional, Keller, Dagmar I., additional, Twerenbold, Raphael, additional, Mueller, Christian, additional, Walter, Joan, additional, Yufera Sanchez, Ana, additional, Puelacher, Christian, additional, du Fay de Lavallaz, Jeanne, additional, Shrestha, Samyut, additional, López, Beatriz, additional, Rodriguez Adrada, Esther, additional, Muzyk, Piotr, additional, Morawiec, Beata, additional, Lohrmann, Jens, additional, Christ, Michael, additional, Ratmann, Paul David, additional, Badertscher, Patrick, additional, Arslani, Ketina, additional, Zimmermann, Tobias, additional, Freese, Michael, additional, Wildi, Karin, additional, Wussler, Desiree, additional, Gualandro, Danielle M, additional, Frey, Simon, additional, and Geigy, Nicolas, additional

Published
2021
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31. Early Diagnosis of Myocardial Infarction in Patients With a History of Coronary Artery Bypass Grafting

Author

Reichlin, Tobias, Zimmermann, Tobias, Meier, Mario, Troester, Valentina, Huber, Jeffrey, Christ, Michael, Badertscher, Patrick, Wildi, Karin, Puelacher, Christian, du Fay de Lavallaz, Jeanne, Giménez, Maria Rubini, Strebel, Ivo, Kozhuharov, Nikola, Gualandro, Danielle M., Potlukova, Eliska, Rentsch, Katharina, Miró, Òscar, Fuenzalida, Carolina, Shrestha, Samyut, Kawecki, Damian, Morawiec, Beata, Munzk, Piotr, Breidthardt, Tobias, Flores, Dayana, Freese, Michael, Stelzig, Claudia, Kulangara, Caroline, Meissner, Kathrin, Fahrni, Gregor, Michou, Eleni, Osswald, Stefan, Jeger, Raban, Kaiser, Christoph, López, Beatriz, Calderón, Sofia, Adrada, Esther Rodriguez, Ganovská, Eva, Parenica, Jiri, von Eckardstein, Arnold, Campodarve, Isabel, Gea, Joachim, Reuthebuch, Oliver, Grapow, Martin, Eckstein, Friedrich, Koechlin, Luca, Boeddinghaus, Jasper, Nestelberger, Thomas, Wussler, Desiree, Walter, Joan, Martin-Sanchez, F. Javier, Geigy, Nicolas, Keller, Dagmar I., Twerenbold, Raphael, and Mueller, Christian

Published
2019
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32. Diagnostic and prognostic value of ST-segment deviation scores in suspected acute myocardial infarction

Author

Grimm, Karin, primary, Twerenbold, Raphael, additional, Abaecherli, Roger, additional, Boeddinghaus, Jasper, additional, Nestelberger, Thomas, additional, Koechlin, Luca, additional, Troester, Valentina, additional, Bourtzou, Anna, additional, Keller, Dagmar I, additional, Geigy, Nicolas, additional, Kozhuharov, Nikola, additional, Wussler, Desiree, additional, Wildi, Karin, additional, Hillinger, Petra, additional, Rubini Giménez, Maria, additional, Strebel, Ivo, additional, Badertscher, Patrick, additional, Puelacher, Christian, additional, du Fay de Lavallaz, Jeanne, additional, Osswald, Luca, additional, Morawiec, Beata, additional, Kawecki, Damian, additional, Miró, Òscar, additional, Kühne, Michael, additional, Reichlin, Tobias, additional, and Mueller, Christian, additional

Published
2020
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33. Effect of a Proposed Modification of the Type 1 and Type 2 Myocardial Infarction Definition on Incidence and Prognosis

Author

Schoepfer, Hadrien, primary, Nestelberger, Thomas, additional, Boeddinghaus, Jasper, additional, Twerenbold, Raphael, additional, Lopez-Ayala, Pedro, additional, Koechlin, Luca, additional, Wussler, Desiree, additional, Zimmermann, Tobias, additional, Miro, Oscar, additional, Martín-Sánchez, Javier F., additional, Christ, Michael, additional, Keller, Dagmar I., additional, Rubini Gimenez, Maria, additional, Mueller, Christian, additional, Gualandro, Danielle M., additional, Arslani, Ketina, additional, Ratmann, Paul David, additional, Hillinger, Petra, additional, Meier, Mario, additional, Coscia, Tania, additional, Freese, Michael, additional, Walter, Joan Elias, additional, Troester, Valentina, additional, Glarner, Noemi, additional, Puelacher, Christian, additional, Badertscher, Patrick, additional, Wildi, Karin, additional, Potlukova, Eliska, additional, Kawecki, Damian, additional, Morawiec, Beata, additional, Buergler, Franz, additional, Geigy, Nicolas, additional, and Reichlin, Tobias, additional

Published
2020
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34. Incidence, characteristics, determinants, and prognostic impact of recurrent syncope

Author

Zimmermann, Tobias, primary, du Fay de Lavallaz, Jeanne, additional, Nestelberger, Thomas, additional, Gualandro, Danielle M, additional, Strebel, Ivo, additional, Badertscher, Patrick, additional, Lopez-Ayala, Pedro, additional, Widmer, Velina, additional, Freese, Michael, additional, Miró, Òscar, additional, Christ, Michael, additional, Cullen, Louise, additional, Than, Martin, additional, Martin-Sanchez, F Javier, additional, Di Somma, Salvatore, additional, Peacock, W Frank, additional, Keller, Dagmar I, additional, Boeddinghaus, Jasper, additional, Twerenbold, Raphael, additional, Wussler, Desiree, additional, Koechlin, Luca, additional, Walter, Joan E, additional, Bürgler, Franz, additional, Geigy, Nicolas, additional, Kühne, Michael, additional, Reichlin, Tobias, additional, Lohrmann, Jens, additional, and Mueller, Christian, additional

Published
2020
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35. Early Diagnosis of Myocardial Infarction With Point-of-Care High-Sensitivity Cardiac Troponin I

Author

Boeddinghaus, Jasper, primary, Nestelberger, Thomas, additional, Koechlin, Luca, additional, Wussler, Desiree, additional, Lopez-Ayala, Pedro, additional, Walter, Joan Elias, additional, Troester, Valentina, additional, Ratmann, Paul David, additional, Seidel, Funda, additional, Zimmermann, Tobias, additional, Badertscher, Patrick, additional, Wildi, Karin, additional, Rubini Giménez, Maria, additional, Potlukova, Eliska, additional, Strebel, Ivo, additional, Freese, Michael, additional, Miró, Òscar, additional, Martin-Sanchez, F. Javier, additional, Kawecki, Damian, additional, Keller, Dagmar I., additional, Gualandro, Danielle M., additional, Christ, Michael, additional, Twerenbold, Raphael, additional, Mueller, Christian, additional, Meier, Mario, additional, Puelacher, Christian, additional, du Fay de Lavallaz, Jeanne, additional, Kozhuharov, Nikola, additional, Rentsch, Katharina, additional, Stelzig, Claudia, additional, Meissner, Kathrin, additional, Kulangara, Caroline, additional, Hillinger, Petra, additional, Michou, Eleni, additional, Flores, Dayana, additional, Reichlin, Tobias, additional, López, Beatriz, additional, Fuenzalida, Carolina, additional, Adrada, Esther Rodriguez, additional, Ganovská, Eva, additional, Lohrmann, Jens, additional, Huber, Jeffrey, additional, Steude, Jana, additional, Buser, Andreas, additional, von Eckardstein, Arnold, additional, Morawiec, Beata, additional, Nowalany-Kozielska, Ewa, additional, Muzyk, Piotr, additional, Bürgler, Franz, additional, and Geigy, Nicolas, additional

Published
2020
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36. Direct comparison of high-sensitivity cardiac troponin Tand I in the early differentiation of type 1 vs. type 2myocardial infarction.

Author

Nestelberger, Thomas, Boeddinghaus, Jasper, Rubini Giménez, Maria, Lopez-Ayala, Pedro, Ratmann, Paul David, Badertscher, Patrick, Wildi, Karin, Wussler, Desiree, Koechlin, Luca, Arslani, Ketina, Zimmermann, Tobias, Freese, Michael, Rinderknecht, Therese, Miró, Òscar, Martin-Sanchez, F. Javier, Kawecki, Damian, Geigy, Nicolas, Keller, Dagmar, Twerenbold, Raphael, and Müller, Christian

Published
2022
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37. Prevalence of pulmonary embolism in patients with syncope

Author

Badertscher, Patrick, du Fay de Lavallaz, Jeanne, Hammerer-Lercher, Angelika, Nestelberger, Thomas, Zimmermann, Tobias, Geiger, Marc, Imahorn, Orell, Miró, Òscar, Salgado, Emilio, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F Javier, Di Somma, Salvatore, Peacock, W Frank, Keller, Dagmar I, Costabel, Juan Pablo, Walter, Joan, Boeddinghaus, Jasper, Twerenbold, Raphael, Méndez, Adriana, Gospodinov, Boris, Puelacher, Christian, Wussler, Desiree, Koechlin, Luca, Kawecki, Damian, Geigy, Nicolas, Strebel, Ivo, Lohrmann, Jens, Kühne, Michael, et al, and University of Zurich

Subjects
540 Chemistry, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine, 10038 Institute of Clinical Chemistry
Published
2019

39. Comparison of fourteen rule-out strategies for acute myocardial infarction

Author

Wildi, Karin, Boeddinghaus, Jasper, Nestelberger, Thomas, Twerenbold, Raphael, Badertscher, Patrick, Wussler, Desiree, Giménez, Maria Rubini, Puelacher, Christian, Du Fay De Lavallaz, Jeanne, Dietsche, Sebastian, Walter, Joan, Kozhuharov, Nikola, Morawiec, Beata, Miró, Òscar, Javier Martin-Sanchez, F, Subramaniam, Sinthuri, Geigy, Nicolas, Keller, Dagmar I, Reichlin, Tobias Roman, Mueller, Christian, University of Zurich, and Mueller, Christian

Subjects
540 Chemistry, 610 Medicine & health, health care economics and organizations, 2705 Cardiology and Cardiovascular Medicine, 10038 Institute of Clinical Chemistry
Abstract

BACKGROUND The clinical availability of high-sensitivity cardiac troponin (hs-cTn) has enabled the development of several innovative strategies for the rapid rule-out of acute myocardial infarction (AMI). Due to the lack of direct comparisons, selection of the best strategy for clinical practice is challenging. METHODS In a prospective international multicenter diagnostic study enrolling 3696 patients presenting with suspected AMI to the emergency department, we compared the safety and efficacy of 14 different hs-cTn-based strategies: hs-cTn concentrations below the limit of detection (LoD), dual-marker combining hs-cTn with copeptin, ESC 0 h/1 h-algorithm, 0 h/2 h-algorithm, 2 h-ADP-algorithm, NICE-algorithm, and ESC 0 h/3 h-algorithm, each using either hs-cTnT or hs-cTnI. The final diagnosis of AMI was adjudicated by two independent cardiologists using all available clinical information including cardiac imaging and serial hs-cTn concentrations. RESULTS AMI was the final diagnosis in 16% of patients. Using hs-cTnT, safety quantified by the negative predictive value (NPV) and sensitivity was very high (99.8-100% and 99.5-100%) and comparable for all strategies, except the dual-marker approach (NPV 98.7%, sensitivity 96.7%). Similarly, using hs-cTnI, safety quantified by the NPV and sensitivity was very high (99.7-100% and 98.9-100%) and comparable for all strategies, except the dual-marker approach (NPV 96.9%, sensitivity 90.4%) and the NICE-algorithm (NPV 99.1%, sensitivity 94.7%). Efficacy, quantified by the percentage of patients eligible for rule-out, differed markedly, and was lowest for LoD-algorithm (15.7-26.8%). CONCLUSION All rapid rule-out algorithms, except the dual-marker strategy and the NICE-algorithm using hs-cTnI, favorably combine safety and efficacy, and can be considered for routine clinical practice. CLINICAL TRIAL REGISTRATION NCT00470587, http://clinicaltrials.gov/show/NCT00470587.

Published
2019
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40. Circadian, weekly, seasonal, and temperature-dependent patterns of syncope aetiology in patients at increased risk of cardiac syncope

Author

du Fay de Lavallaz, Jeanne, Badertscher, Patrick, Nestelberger, Thomas, Flores, Dayana, Miró, Òscar, Salgado, Emilio, Geigy, Nicolas, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F Javier, Rodriguez-Adrada, Esther, Di Somma, Salvatore, Peacock, W Frank, Kawecki, Damian, Boeddinghaus, Jasper, Twerenbold, Raphael, Puelacher, Christian, Wussler, Desiree, Strebel, Ivo, Keller, Dagmar I, Poepping, Imke, Kühne, Michael, Reichlin, Tobias, Mueller, Christian, BASEL IX Investigators, University of Zurich, and Mueller, Christian

Subjects
2737 Physiology (medical), 540 Chemistry, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine, 10038 Institute of Clinical Chemistry
Published
2019

41. Inflammatory Biomarkers and Clinical Judgment in the Emergency Diagnosis of Urgent Abdominal Pain

Author

Breidthardt, Tobias, Brunner-Schaub, Nora, Balmelli, Catharina, Insenser, Juan Jose Sancho, Burri-Winkler, Katrin, Geigy, Nicolas, Mundorff, Lukas, Exadaktylos, Aristomenis, Scholz, Julia, Haaf, Philip, Hamel, Christian, Frey, Daniel, Delport, Karen, Peacock, W. Frank, Freese, Michael, DiSomma, Salvatore, Todd, John, Rentsch, Katharina, Bingisser, Roland, and Mueller, Christian

Subjects
610 Medicine & health
Abstract

BACKGROUND: The early diagnosis of urgent abdominal pain (UAP) is challenging. Most causes of UAP are associated with extensive inflammation. Therefore, we hypothesized that quantifying inflammation using interleukin-6 and/or procalcitonin would provide incremental value in the emergency diagnosis of UAP. METHODS: This was an investigator-initiated prospective, multicenter diagnostic study enrolling patients presenting to the emergency department (ED) with acute abdominal pain. Clinical judgment of the treating physician regarding the presence of UAP was quantified using a visual analog scale after initial clinical and physician-directed laboratory assessment, and again after imaging. Two independent specialists adjudicated the final diagnosis and the classification as UAP (life-threatening, needing urgent surgery and/or hospitalization for acute medical reasons) using all information including histology and follow-up. Interleukin-6 and procalcitonin were measured blinded in a central laboratory. RESULTS: UAP was adjudicated in 376 of 1038 (36%) patients. Diagnostic accuracy for UAP was higher for interleukin-6 [area under the ROC curve (AUC), 0.80; 95% CI, 0.77-0.82] vs procalcitonin (AUC, 0.65; 95% CI, 0.62-0.68) and clinical judgment (AUC, 0.69; 95% CI, 0.65-0.72; both P < 0.001). Combined assessment of interleukin-6 and clinical judgment increased the AUC at presentation to 0.83 (95% CI, 0.80-0.85) and after imaging to 0.87 (95% CI, 0.84-0.89) and improved the correct identification of patients with and without UAP (net improvement in mean predicted probability: presentation, +19%; after imaging, +15%; P < 0.001). Decision curve analysis documented incremental value across the full range of pretest probabilities. A clinical judgment/interleukin-6 algorithm ruled out UAP with a sensitivity of 97% and ruled in UAP with a specificity of 93%. CONCLUSIONS: Interleukin-6 significantly improves the early diagnosis of UAP in the ED.

Published
2019
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42. Clinical Use of a New High-Sensitivity Cardiac Troponin I Assay in Patients with Suspected Myocardial Infarction

Author

Boeddinghaus, Jasper, Twerenbold, Raphael, Nestelberger, Thomas, Koechlin, Luca, Wussler, Desiree, Meier, Mario, Troester, Valentina, Zimmermann, Tobias, Badertscher, Patrick, Wildi, Karin, Rubini Giménez, Maria, Lopez-Ayala, Pedro, Potlukova, Eliska, Miró, Òscar, Martin-Sanchez, F Javier, Kawecki, Damian, Geigy, Nicolas, Keller, Dagmar I, Reichlin, Tobias, and Mueller, Christian

Subjects
cardiovascular system, cardiovascular diseases, macromolecular substances, musculoskeletal system, 610 Medicine & health
Abstract

BACKGROUND We aimed to validate the clinical performance of the high-sensitivity cardiac troponin I [VITROS® Immunodiagnostic Products hs Troponin I (hs-cTnI-VITROS)] assay. METHODS We enrolled patients presenting to the emergency department with symptoms suggestive of acute myocardial infarction (AMI). Final diagnoses were centrally adjudicated by 2 independent cardiologists considering all clinical information, including cardiac imaging: first, using serial hs-cTnT-Elecsys (primary analysis) and, second, using hs-cTnI-Architect (secondary analysis) measurements in addition to the clinically used (hs)-cTn. hs-cTnI-VITROS was measured at presentation and at 1 h in a blinded fashion. The primary objective was direct comparison of diagnostic accuracy as quantified by the area under the ROC curve (AUC) of hs-cTnI-VITROS vs hs-cTnT-Elecsys and hs-cTnI-Architect, and in a subgroup also hs-cTnI-Centaur and hs-cTnI-Access. Secondary objectives included the derivation and validation of an hs-cTnI-VITROS-0/1-h algorithm. RESULTS AMI was the adjudicated final diagnosis in 158 of 1231 (13%) patients. At presentation, the AUC for hs-cTnI-VITROS was 0.95 (95% CI, 0.93-0.96); for hs-cTnT-Elecsys, 0.94 (95% CI, 0.92-0.95); and for hs-cTnI-Architect, 0.92 (95% CI, 0.90-0.94). AUCs for hs-cTnI-Centaur and hs-cTnI-Access were 0.95 (95% CI, 0.94-0.97). Applying the derived hs-cTnI-VITROS-0/1-h algorithm (derivation cohort n = 519) to the validation cohort (n = 520), 53% of patients were ruled out [sensitivity, 100% (95% CI, 94.1-100)] and 14% of patients were ruled in [specificity, 95.6% (95% CI, 93.4-97.2)]. Patients ruled out by the 0/1-h algorithm had a survival rate of 99.8% at 30 days. Findings were confirmed in the secondary analyses using the adjudication including serial measurements of hs-cTnI-Architect. CONCLUSIONS The hs-cTnI-VITROS assay has at least comparable diagnostic accuracy with the currently best validated hs-cTnT and hs-cTnI assays. CLINICALTRIALSGOV IDENTIFIER NCT00470587.

Published
2019
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43. Diagnosis of acute myocardial infarction in the presence of left bundle branch block

Author

Nestelberger, Thomas, Cullen, Louise, Lindahl, Bertil, Reichlin, Tobias, Greenslade, Jaimi H., Giannitsis, Evangelos, Christ, Michael, Morawiec, Beata, Miro, Oscar, Martín-Sánchez, Francisco Javier, Wussler, Desiree Nadine, Koechlin, Luca, Twerenbold, Raphael, Parsonage, William, Boeddinghaus, Jasper, Rubini Gimenez, Maria, Puelacher, Christian, Wildi, Karin, Buerge, Tobias, Badertscher, Patrick, DuFaydeLavallaz, Jeanne, Strebel, Ivo, Croton, Lukas, Bendig, Garnet, Osswald, Stefan, Pickering, John William, Than, Martin, Mueller, Christian, Hillinger, Petra, Grimm, Karin, Honegger, Ursina, Schaerli, Nicolas, Kozhuharov, Nikola, Stelzig, Claudia, Freese, Michael, Sabti, Zaid, Walter, Joan, Sazgary, Lorraine, Kulangara, Caroline, Meissner, Kathrin, Mueller, Deborah, Lopez, Beatriz, Salgado, Emilio, Adrada, Esther Rodríguez, Kawecki, Damian, Parenica, Jiri, Ganovska, Eva, Rentsch, Katharina, Buser, Andreas, Lohrmann, Jens, Bingisser, Roland, Shrestha, Samyut, Stallone, Fabio, Abaecherli, Roger, McCord, James, Nowak, Richard, Body, Richard, DeFilippi, Christopher R., Christenson, Robert H., Panteghini, Mauro, Plebani, Mario, Verschuren, Franck, French, John, Weiser, Silvia, Dinkel, Carina, Keller, Dagmar I., Geigy, Nicolas, Nestelberger, Thomas, Cullen, Louise, Lindahl, Bertil, Reichlin, Tobias, Greenslade, Jaimi H., Giannitsis, Evangelos, Christ, Michael, Morawiec, Beata, Miro, Oscar, Martín-Sánchez, Francisco Javier, Wussler, Desiree Nadine, Koechlin, Luca, Twerenbold, Raphael, Parsonage, William, Boeddinghaus, Jasper, Rubini Gimenez, Maria, Puelacher, Christian, Wildi, Karin, Buerge, Tobias, Badertscher, Patrick, DuFaydeLavallaz, Jeanne, Strebel, Ivo, Croton, Lukas, Bendig, Garnet, Osswald, Stefan, Pickering, John William, Than, Martin, Mueller, Christian, Hillinger, Petra, Grimm, Karin, Honegger, Ursina, Schaerli, Nicolas, Kozhuharov, Nikola, Stelzig, Claudia, Freese, Michael, Sabti, Zaid, Walter, Joan, Sazgary, Lorraine, Kulangara, Caroline, Meissner, Kathrin, Mueller, Deborah, Lopez, Beatriz, Salgado, Emilio, Adrada, Esther Rodríguez, Kawecki, Damian, Parenica, Jiri, Ganovska, Eva, Rentsch, Katharina, Buser, Andreas, Lohrmann, Jens, Bingisser, Roland, Shrestha, Samyut, Stallone, Fabio, Abaecherli, Roger, McCord, James, Nowak, Richard, Body, Richard, DeFilippi, Christopher R., Christenson, Robert H., Panteghini, Mauro, Plebani, Mario, Verschuren, Franck, French, John, Weiser, Silvia, Dinkel, Carina, Keller, Dagmar I., and Geigy, Nicolas

Abstract

Objective Patients with suspected acute myocardial infarction (AMI) in the setting of left bundle branch block (LBBB) present an important diagnostic and therapeutic challenge to the clinician. Methods We prospectively evaluated the incidence of AMI and diagnostic performance of specific ECG and high-sensitivity cardiac troponin (hs-cTn) criteria in patients presenting with chest discomfort to 26 emergency departments in three international, prospective, diagnostic studies. The final diagnosis of AMI was centrally adjudicated by two independent cardiologists according to the universal definition of myocardial infarction. Results Among 8830 patients, LBBB was present in 247 (2.8%). AMI was the final diagnosis in 30% of patients with LBBB, with similar incidence in those with known LBBB versus those with presumably new LBBB (29% vs 35%, p=0.42). ECG criteria had low sensitivity (1%-12%) but high specificity (95%-100%) for AMI. The diagnostic accuracy as quantified by the receiver operating characteristics (ROC) curve of hs-cTnT and hs-cTnI concentrations at presentation (area under the ROC curve (AUC) 0.91, 95% CI 0.85 to 0.96 and AUC 0.89, 95% CI 0.83 to 0.95), as well as that of their 0/1-hour and 0/2-hour changes, was very high. A diagnostic algorithm combining ECG criteria with hs-cTnT/I concentrations and their absolute changes at 1 hour or 2 hours derived in cohort 1 (45 of 45(100%) patients with AMI correctly identified) showed high efficacy and accuracy when externally validated in cohorts 2 and 3 (28 of 29 patients, 97%). Conclusion Most patients presenting with suspected AMI and LBBB will be found to have diagnoses other than AMI. Combining ECG criteria with hs-cTnT/I testing at 0/1 hour or 0/2 hours allows early and accurate diagnosis of AMI in LBBB. Trial registration number APACE: NCT00470587; ADAPT: ACTRN12611001069943; TRAPID-AMI: RD001107;Results.

Published
2019

44. Two-hour algorithm for rapid triage of suspected acute myocardial infarction using a high-sensitivity cardiac troponin I assay

Author

Nestelberger, Thomas, Boeddinghaus, Jasper, Greenslade, Jaimi, Parsonage, William A., Than, Martin, Wussler, Desiree, Lopez-Ayala, Pedro, Zimmermann, Tobias, Meier, Mario, Troester, Valentina, Badertscher, Patrick, Koechlin, Luca, Wildi, Karin, Anwar, Mahnoor, Freese, Michael, Keller, Dagmar I., Reichlin, Tobias, Twerenbold, Raphael, Cullen, Louise, Mueller, Christian, Puelacher, Christian, Du Fay De Lavallaz, Jeanne, Giménez, Maria Rubini, Strebel, Ivo, Walter, Joan, Huber, Jeffrey, Christ, Michael, Kozhuharov, Nikola, Gualandro, Danielle M., Potlukova, Eliska, Baumgartner, Benjamin, Hafner, Benjamin, Rent-Sch, Katharina, Miró, Òscar, Fuenzalida, Carolina, Gil, Beatriz, Javier Martin-Sanchez, F., Kawecki, Damian, Geigy, Nicolas, Meissner, Kathrin, Kulangara, Caroline, López, Beatriz, Adrada, Esther Rodriguez, Ganovská, Eva, Lohrmann, Jens, Kloos, Wanda, Steude, Jana, Buser, Andreas, Von Eckardstein, Arnold, Nowalany-Kozielska, Ewa, Muzyk, Piotr, Nestelberger, Thomas, Boeddinghaus, Jasper, Greenslade, Jaimi, Parsonage, William A., Than, Martin, Wussler, Desiree, Lopez-Ayala, Pedro, Zimmermann, Tobias, Meier, Mario, Troester, Valentina, Badertscher, Patrick, Koechlin, Luca, Wildi, Karin, Anwar, Mahnoor, Freese, Michael, Keller, Dagmar I., Reichlin, Tobias, Twerenbold, Raphael, Cullen, Louise, Mueller, Christian, Puelacher, Christian, Du Fay De Lavallaz, Jeanne, Giménez, Maria Rubini, Strebel, Ivo, Walter, Joan, Huber, Jeffrey, Christ, Michael, Kozhuharov, Nikola, Gualandro, Danielle M., Potlukova, Eliska, Baumgartner, Benjamin, Hafner, Benjamin, Rent-Sch, Katharina, Miró, Òscar, Fuenzalida, Carolina, Gil, Beatriz, Javier Martin-Sanchez, F., Kawecki, Damian, Geigy, Nicolas, Meissner, Kathrin, Kulangara, Caroline, López, Beatriz, Adrada, Esther Rodriguez, Ganovská, Eva, Lohrmann, Jens, Kloos, Wanda, Steude, Jana, Buser, Andreas, Von Eckardstein, Arnold, Nowalany-Kozielska, Ewa, and Muzyk, Piotr

Abstract

BACKGROUND We aimed to derive and externally validate a 0/2-h algorithm using the high-sensitivity cardiac troponin I (hs-cTnI)-Access assay. METHODS We enrolled patients presenting to the emergency department with symptoms suggestive of acute myocardial infarction (AMI) in 2 prospective diagnostic studies using central adjudication. Two independent cardiologists adjudicated the final diagnosis, including all available medical information including cardiac imaging. hs-cTnI-Access concentrations were measured at presentation and after 2 h in a blinded fashion. RESULTS AMI was the adjudicated final diagnosis in 164 of 1131 (14.5%) patients in the derivation cohort. Rule-out by the hs-cTnI-Access 0/2-h algorithm was defined as 0-h hs-cTnI-Access concentration <4 ng/L in patients with an onset of chest pain >3 h (direct rule-out) or a 0-h hs-cTnI-Access concentration <5 ng/L and an absolute change within 2 h <5 ng/L in all other patients. Derived thresholds for rule-in were a 0-h hs-cTnI-Access concentration ≥50 ng/L (direct rule-in) or an absolute change within 2 h ≥20 ng/L. In the derivation cohort, these cutoffs ruled out 55% of patients with a negative predictive value (NPV) of 99.8% (95% CI, 99.3–100) and sensitivity of 99.4% (95% CI, 96.5–99.9), and ruled in 30% of patients with a positive predictive value (PPV) of 73% (95% CI, 66.1–79). In the validation cohort, AMI was the adjudicated final diagnosis in 88 of 1280 (6.9%) patients. These cutoffs ruled out 77.9% of patients with an NPV of 99.8% (95% CI, 99.3–100) and sensitivity of 97.7% (95% CI, 92.0–99.7), and ruled in 5.8% of patients with a PPV of 77% (95% CI, 65.8–86) in the validation cohort. CONCLUSIONS Safety and efficacy of the l hs-cTnI-Access 0/2-h algorithm for triage toward rule-out or rule-in of AMI are very high.

Published
2019

45. Impact of age on the performance of the ESC 0/1h-algorithms for early diagnosis of myocardial infarction

Author

Boeddinghaus, Jasper, Nestelberger, Thomas, Twerenbold, Raphael, et al, Badertscher, Patrick, Jann, Janina E, Wussler, Desiree, Puelacher, Christian, Rubini Giménez, Maria, Wildi, Karin, Strebel, Ivo, Du Fay de Lavallaz, Jeanne, Selman, Farah, Sabti, Zaid, Kozhuharov, Nikola, Potlukova, Eliska, Rentsch, Katharina, Lohrmann, Jens, Kloos, Wanda, Buser, Andreas, Geigy, Nicolas, Keller, Dagmar I, Osswald, Stefan, Reichlin, T, Mueller, Christian, University of Zurich, and Mueller, Christian

Subjects
540 Chemistry, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine, 10038 Institute of Clinical Chemistry
Published
2018

46. Clinical Validation of a Novel High-Sensitivity Cardiac Troponin I Assay for Early Diagnosis of Acute Myocardial Infarction

Author

Boeddinghaus, Jasper, Twerenbold, Raphael, Nestelberger, Thomas, Badertscher, Patrick, Wildi, Karin, Puelacher, Christian, Du Fay De Lavallaz, Jeanne, Keser, Elif, Rubini Giménez, Maria, Wussler, Desiree, Kozhuharov, Nikola, Rentsch, Katharina, Miró, Òscar, Martin-Sanchez, F Javier, Morawiec, Beata, Stefanelli, Sabrina, Geigy, Nicolas, Keller, Dagmar I, Reichlin, Tobias Roman, and Mueller, Christian

Subjects
610 Medicine & health
Abstract

BACKGROUND Clinical performance of the novel high-sensitivity cardiac troponin I (Siemens-hs-cTnI-Centaur) assay is unknown. We aimed to clinically validate the Siemens-hs-cTnI-Centaur assay and develop 0/1-h and 0/2-h algorithms. METHODS We enrolled patients presenting to the emergency department with symptoms suggestive of acute myocardial infarction (AMI). Final diagnoses were centrally adjudicated by 2 independent cardiologists including all clinical information twice: first, using serial hs-cTnT (Roche-Elecsys, primary analysis); second, using hs-cTnI (Abbott-Architect, secondary analysis) measurements in addition to the clinically applied (hs)-cTn. Siemens-hs-cTnI-Centaur was measured at presentation, 1 h, and 2 h. The primary objective was a direct comparison of diagnostic accuracy, quantified by the area under the ROC curve (AUC), of Siemens-hs-cTnI-Centaur vs the 2 established hs-cTn assays (Roche-hs-cTnT-Elecsys, Abbott-hs-cTnI-Architect). Secondary objectives included the development of Siemens-hs-cTnI-Centaur-specific 0/1-h and 0/2-h algorithms. RESULTS AMI was the final diagnosis in 318 of 1755 (18%) patients (using Roche-hs-cTnT-Elecsys for adjudication). The AUC at presentation for Siemens-hs-cTnI-Centaur was 0.94 (95% CI, 0.92-0.96) and comparable with 0.95 (95% CI, 0.93-0.97) for Roche-hs-cTnT-Elecsys and 0.93 (95% CI, 0.90-0.96) for Abbott-hs-cTnI-Architect. Applying the derived Siemens-hs-cTnI-Centaur 0/1-h algorithm to the validation cohort, 46% of patients were ruled out (sensitivity, 99.1%; 95% CI, 95.3-100), and 18% of patients were ruled in (specificity, 94.1%; 95% CI, 91.8-95.9). The Siemens-hs-cTnI-Centaur 0/2-h algorithm ruled out 55% of patients (sensitivity, 100%; 95% CI, 94.1-100), and ruled in 18% of patients (specificity, 96.0%; 95% CI, 93.1-97.9). Findings were confirmed in the secondary analyses using serial measurements of Abbott-hs-cTnI-Architect for adjudication. CONCLUSIONS Diagnostic accuracy and clinical utility of the novel Siemens-hs-cTnI-Centaur assay are high and comparable with the established hs-cTn assays. ClinicalTrials.gov Identifier: NCT00470587.

Published
2018
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47. Two-Hour Algorithm for Rapid Triage of Suspected Acute Myocardial Infarction Using a High-Sensitivity Cardiac Troponin I Assay

Author

Nestelberger, Thomas, primary, Boeddinghaus, Jasper, additional, Greenslade, Jaimi, additional, Parsonage, William A, additional, Than, Martin, additional, Wussler, Desiree, additional, Lopez-Ayala, Pedro, additional, Zimmermann, Tobias, additional, Meier, Mario, additional, Troester, Valentina, additional, Badertscher, Patrick, additional, Koechlin, Luca, additional, Wildi, Karin, additional, Anwar, Mahnoor, additional, Freese, Michael, additional, Keller, Dagmar I, additional, Reichlin, Tobias, additional, Twerenbold, Raphael, additional, Cullen, Louise, additional, Mueller, Christian, additional, Puelacher, Christian, additional, du Fay de Lavallaz, Jeanne, additional, Rubini Giménez, Maria, additional, Strebel, Ivo, additional, Walter, Joan, additional, Huber, Jeffrey, additional, Christ, Michael, additional, Kozhuharov, Nikola, additional, Gualandro, Danielle M, additional, Potlukova, Eliska, additional, Baumgartner, Benjamin, additional, Hafner, Benjamin, additional, Rentsch, Katharina, additional, Miró, Òscar, additional, Fuenzalida, Carolina, additional, Gil, Beatriz, additional, Martin-Sanchez, F Javier, additional, Kawecki, Damian, additional, Geigy, Nicolas, additional, Meissner, Kathrin, additional, Kulangara, Caroline, additional, López, Beatriz, additional, Rodriguez Adrada, Esther, additional, Ganovská, Eva, additional, Lohrmann, Jens, additional, Kloos, Wanda, additional, Steude, Jana, additional, Buser, Andreas, additional, von Eckardstein, Arnold, additional, Nowalany-Kozielska, Ewa, additional, and Muzyk, Piotr, additional

Published
2019
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48. Clinical Use of a New High-Sensitivity Cardiac Troponin I Assay in Patients with Suspected Myocardial Infarction

Author

Boeddinghaus, Jasper, primary, Twerenbold, Raphael, additional, Nestelberger, Thomas, additional, Koechlin, Luca, additional, Wussler, Desiree, additional, Meier, Mario, additional, Troester, Valentina, additional, Zimmermann, Tobias, additional, Badertscher, Patrick, additional, Wildi, Karin, additional, Rubini Giménez, Maria, additional, Lopez-Ayala, Pedro, additional, Potlukova, Eliska, additional, Miró, Òscar, additional, Martin-Sanchez, F Javier, additional, Kawecki, Damian, additional, Geigy, Nicolas, additional, Keller, Dagmar I, additional, Reichlin, Tobias, additional, Mueller, Christian, additional, du Fay de Lavallaz, Jeanne, additional, Walter, Joan Elias, additional, Freese, Michael, additional, Puelacher, Christian, additional, Hafner, Benjamin, additional, Strebel, Ivo, additional, Kozhuharov, Nikola, additional, Rentsch, Katharina, additional, Gualandro, Danielle M, additional, Schaerli, Nicolas, additional, Stelzig, Claudia, additional, Meissner, Kathrin, additional, Kulangara, Caroline, additional, Hillinger, Petra, additional, Grimm, Karin, additional, Michou, Eleni, additional, Flores, Dayana, additional, Czmok, Rafael, additional, Osswald, Stefan, additional, López, Beatriz, additional, Fuenzalida, Carolina, additional, Rodriguez Adrada, Esther, additional, Ganovská, Eva, additional, Lohrmann, Jens, additional, Kloos, Wanda, additional, Christ, Michael, additional, Steude, Jana, additional, Fahrni, Gregor, additional, Buser, Andreas, additional, von Eckardstein, Arnold, additional, Morawiec, Beata, additional, Nowalany-Kozielska, Ewa, additional, and Muzyk, Piotr, additional

Published
2019
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49. Growth differentiation factor-15 and all-cause mortality in patients with suspected myocardial infarction

Author

Walter, Joan, primary, Nestelberger, Thomas, additional, Boeddinghaus, Jasper, additional, Twerenbold, Raphael, additional, Croton, Lukas, additional, Badertscher, Patrick, additional, Wildi, Karin, additional, Wussler, Desiree, additional, du Fay de Lavallaz, Jeanne, additional, Mueller, Christian, additional, Giménez, Maria Rubini, additional, Puelacher, Christian, additional, Kozhuharov, Nikola, additional, Morawiec, Beata, additional, Rentsch, Katharina, additional, Miró, Òscar, additional, Martin-Sanchez, F. Javier, additional, Muzyk, Piotr, additional, Geigy, Nicolas, additional, Keller, Dagmar I., additional, Reichlin, Tobias, additional, Lohrmann, Jens, additional, Biskup, Ewalina, additional, Kloos, Wanda, additional, López, Beatriz, additional, Inostroza, Carolina Fuenzalida, additional, Adrada, Esther Rodriguez, additional, Kawecki, Damian, additional, Nowalany-Kozielska, Ewa, additional, Parenica, Jiri, additional, Meissner, Kathrin, additional, Kulangara, Caroline, additional, Mahfouz, Riham, additional, and von Eckardstein, Arnold, additional

Published
2019
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50. Prospective validation of current quantitative electrocardiographic criteria for ST-elevation myocardial infarction

Author

Hillinger, Petra, primary, Strebel, Ivo, additional, Abächerli, Roger, additional, Twerenbold, Raphael, additional, Wildi, Karin, additional, Bernhard, Denise, additional, Nestelberger, Thomas, additional, Boeddinghaus, Jasper, additional, Badertscher, Patrick, additional, Wussler, Desiree, additional, Koechlin, Luca, additional, Zimmermann, Tobias, additional, Puelacher, Christian, additional, Rubini Gimenez, Maria, additional, du Fay de Lavallaz, Jeanne, additional, Walter, Joan, additional, Geigy, Nicolas, additional, Keller, Dagmar I., additional, Reichlin, Tobias, additional, and Mueller, Christian, additional

Published
2019
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