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9. Poster Sessions

Author

Fredrik Y. Frejd, Stefan Ståhl, Ekerljung L, Wållberg H, Sohrabian A, Tarek Bass, Gedda L, Anderson K, and Friedman M

Subjects
0303 health sciences, 03 medical and health sciences, 0302 clinical medicine, Text mining, business.industry, 030220 oncology & carcinogenesis, Immunology, Immunology and Allergy, Medicine, Computational biology, business, 030304 developmental biology
Published
2012

11. Spontaneous Drawing and the Individuality of Twins

Author

Gedda L

Subjects
Male, media_common.quotation_subject, Perspective (graphical), Individuality, Twins, Subject (philosophy), Twins, Monozygotic, Creativity, Test (assessment), Twins, Dizygotic, Humans, Female, Child, First impression (psychology), Psychology, Art, Genetics (clinical), Cognitive psychology, media_common
Abstract

Only rarely have geneticists, neurobiologists and psychologists availed themselves of twins for the study of the human mind's individuality. I believe, on the contrary, that twin data represent an invaluable means of research also for phenomena connected with human individuality and the functioning of the nervous system.To this end I thought of having MZ and DZ twins take a creativity test by means of spontaneous drawings of a single subject applied to individual MZ and DZ twin pairs.The preselected twins totalled 31 MZ and 13 DZ pairs of an age span during which the twins live together and experience the same environmental influences.The creativity test I devised consists of asking the twins to make a drawing of the family mealtime scene at which they all participate. The drawings were to be made on identical pieces of white paper, selecting colors from the same box of colored pencils given to each of them. When the test was explained, each twin was placed in a different room with no possibility of communication, and was asked to make the drawing, supervised at a distance by an assistant.In order to analyze the drawings, I established ten parameters: 1) First impression at a glance; 2) Choice of colors; 3) Choice of perspective; 4) Choice of persons' positions; 5) Emphasis on twins; 6) Shape of table; 7) Table settings and food dishes; 8) Room furniture; 9) Drawing of building; 10) Landscape.

Published
1991

15. Generation and evaluation of bispecific affibody molecules for simultaneous targeting of EGFR and HER2

Author

Ekerljung, L., Wållberg, Helena, Sohrabian, A., Andersson, K., Friedman, M., Frejd, F. Y., Ståhl, Stefan, Gedda, L., Ekerljung, L., Wållberg, Helena, Sohrabian, A., Andersson, K., Friedman, M., Frejd, F. Y., Ståhl, Stefan, and Gedda, L.

Abstract

Coexpression of several ErbB receptors has been found in many cancers and has been linked with increased aggressiveness of tumors and a worse patient prognosis. This makes the simultaneous targeting of two surface receptors by using bispecific constructs an increasingly appreciated strategy. Here, we have generated six such bispecific targeting proteins, each comprising two monomeric affibody molecules with specific binding to either of the two human epidermal growth factor receptors, EGFR and HER2, respectively. The bispecific constructs were designed with (i) alternative positioning (N- or C-terminal) of the different affibody molecules, (ii) two alternative peptide linkers (Gly 4Ser) 3 or (Ser 4Gly) 3, and (iii) affibody molecules with different affinity (nanomolar or picomolar) for HER2. Using both Biacore technology and cell binding assays, it was demonstrated that all six constructs could bind simultaneously to both their target proteins. N-terminal positioning of the inherent monomeric affibody molecules was favorable to promote the binding to the respective target. Interestingly, bispecific constructs containing the novel (Ser 4Gly) 3 linker displayed a higher affinity in cell binding, as compared to constructs containing the more conventional linker, (Gly 4Ser) 3. It could further be concluded that bispecific constructs (but not the monomeric affibody molecules) induced dimer formation and phosphorylation of EGFR in SKBR3 cells, which express fairly high levels of both receptors. It was also investigated whether the bispecific binding would influence cell growth or sensitize cells for ionizing radiation, but no such effects were observed., QC 20121015

Published
2012
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16. Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin

Author

Wu, X., Wanders, A., Wardega, P., Tinge, B., Gedda, L., Bergstrom, S., Sooman, L., Gullbo, J., Bergqvist, M., Hesselius, P., Lennartsson, J., Ekman, S., Wu, X., Wanders, A., Wardega, P., Tinge, B., Gedda, L., Bergstrom, S., Sooman, L., Gullbo, J., Bergqvist, M., Hesselius, P., Lennartsson, J., and Ekman, S.

Abstract

Heat shock protein 90 (Hsp90) has been demonstrated to protect oncogenic variants of signalling molecules from degradation and may consequently serve as a therapeutic target for the treatment of oesophageal cancer for which adequate therapy is often lacking. We studied the expression of Hsp90 in tumour tissues of human oesophageal cancer and the impact of Hsp90 inhibition on oesophageal cancer cell lines using the drug 17-allylamino-17-demethoxygeldanamycin (17-AAG). Quantitative immunohistochemistry was performed on formalin-fixed paraffin-embedded tissues from patients with oesophageal cancer. In squamous cell carcinoma, a marked upregulation of Hsp90 could be noted in dysplastic epithelium and invasive cancer compared with normal epithelium. In adenocarcinoma, Hsp90 was expressed in neoplastic epithelium and also in normal non-neoplastic glands weakly. The inhibition of Hsp90 using 17-AAG led to a significant decrease in cell proliferation and viability in human oesophageal cancer cell lines. Using a clonogenic cell survival assay, Hsp90 inhibition significantly sensitised the cells for gamma-photon irradiation. Heat shock protein 90 was found to be critical for proper signalling induced by both epidermal growth factor and insulin-like growth factor-1, in which the inhibition of signalling by 17-AAG correlated with the observed reduction in cell proliferation and viability. These results showed that Hsp90 was selectively expressed in oesophageal cancer tissue compared with the corresponding normal tissue, and the inhibition of Hsp90 resulted in decreased proliferation and viability as well as radiosensitisation of oesophageal cancer cells. Heat shock protein 90 represents a potential therapeutic target in the treatment of patients with oesophageal cancer, alone or in combination with radiotherapy., Wu, X Wanders, A Wardega, P Tinge, B Gedda, L Bergstrom, S Sooman, L Gullbo, J Bergqvist, M Hesselius, P Lennartsson, J Ekman, S eng Research Support, Non-U.S. Gov't England 2009/01/15 09:00 Br J Cancer. 2009 Jan 27;100(2):334-43. doi: 10.1038/sj.bjc.6604855. Epub 2009 Jan 13.

Published
2009

20. Preclinical research on Auger therapy

Author

Lundqvist, H, Bohl, E, Carlsson, J, Gedda, L, Tolmachev, V, Orlova, A, Bruskin, A, Sjöberg, S, Lundqvist, H, Bohl, E, Carlsson, J, Gedda, L, Tolmachev, V, Orlova, A, Bruskin, A, and Sjöberg, S

Published
2003

39. Carboranyl phenantridinium analogues: Synthesis and biological evaluation.

Author

Tjarks, W, Gedda, L, Silvander, M, Mars, U, Ghaneolhosseini, H, Henssen, C, Olsson, P, Sjoberg, S, Carlsson, J, Larsson, B, Edwards, K, Tjarks, W, Gedda, L, Silvander, M, Mars, U, Ghaneolhosseini, H, Henssen, C, Olsson, P, Sjoberg, S, Carlsson, J, Larsson, B, and Edwards, K

Published
1997

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