34 results on '"Geccherle, Andrea"'
Search Results
2. Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies
- Author
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Abrahamovych, Orest, Abu-farsakh, Niazy, Afanasieva, Halyna, Akpinar, Hale, Al Kharrat, Houssam, Altintas, Engin, Altwegg, Romain, Andreev, Pavel, Aomatsu, Kazuki, Araki, Hiroshi, Argollo, Marjorie, Ariel, Federico, Armuzzi, Alessandro, Ashida, Toshifumi, Augustyn, Monika, Aumais, Guy, Azum, Martín, Baert, Filip, Balaz, Jozef, Balderramo, Domingo, Begun, Jakob, Berova, Temenuzhka, Billiauws, Lore, Blanco, Antonio, Bortlik, Martin, Bossa, Fabrizio, Bunkova, Elena, Cabello, Mercedes, Cao, Qian, Caprioli, Flavio, Cerqueira, Rute, Chachu, Karen, Chamouard, Patrick, Chen, Chunxiao, Chen, Yan, Chen, Baili, Chen, Dongfeng, Chen, Hong, Chen, Youxiang, Chen, Chou-chen, Cheon, Jaehee, Chen, Minhu, Chiu, Cheng-tang, Choi, Changhwan, Chow, Elizabeth, Cicala, Michele, Cintra, Aderson, Danilkiewicz, Wit, Datsenko, Olena, De Hertogh, Gert, De María, Julio, Del Valle Torrealba Medina, Leyanira, Deliang, Liu, Desreumaux, Pierre, Dewint, Pieter, Ding, Shigang, Doherty, Glen, Draganova, Raina, Dutré, Joris, Duvall, George, Egan, Laurence, Fahed, Julien, Fechner, Lars, Fedurco, Miroslav, Ferhat Celik, Aykut, Fernandez, Juan, Filip, Rafal, Fishman, Sigal, Flores, Cristina, Fogel, Ronald, Fowler, Sharyle, Francesconi, Carlos, Fujii, Toshimitsu, Fujiya, Mikihiro, Fukata, Masayuki, Fukuhara, Seiichiro, Furumoto, Yohei, G.Kiss, Gyula, Gachowski, Waldemar, Gao, Xiang, Gasbarrini, Antonio, Gawdis-wojnarska, Beata, Gaya, Daniel, Geccherle, Andrea, Gilletta De Saint Joseph, Cyrielle, Gimenez, Edgardo, Gionchetti, Paolo, Goldin, Eran, Golovchenko, Oleksandr, Gonciarz, Maciej, Gonen, Can, Gonzales, Chad, Gonzalez, Raquel, Gonzalez Segura, Gaston Julian, Gridnyev, Oleksiy, Gu, Fang, Gupta, Nitin, Gyokeres, Tibor, Haines, Melissa, Hebuterne, Xavier, Hedin, Charlotte, Hellstrom, Per, Hilmi, Ida Normiha, Hirai, Fumihito, Hisabe, Takashi, Hlavaty, Tibor, Hoentjen, Frank, Holtmann, Gerald, Horiki, Noriyuki, Horny, Ivo, Horvat, Gyula, Horvath, Frantisek, Hoshi, Namiko, Hosomi, Shuhei, Hospodarskyy, Ihor, Hou, Xiaohua, Hrdlicka, Ludek, Hu, Naizhong, Huang, Vivian, Huang, Caibin, Inaba, Tomoki, Ishiguro, Yoh, Ishihara, Shunji, Ishikawa, Takeshi, Iskandar, Heba, Israeli, Eran, Itaba, Soichi, Ivanishyn, Olha, Izbéki, Ferenc, Jain, Animesh, Jairath, Vipul, Jang, Byung Ik, Jiang, Chunmeng, Jones, Michael, Kagaya, Takashi, Kalimullina, Dilara, Karakina, Marina, Karatas, Ali, Kashimura, Hiroshi, Keret, Dan, Khovaeva, Yaroslava, Kierkus, Jaroslaw, Kim, Taeoh, Kim, Youngho, Kim, Hyo Jong, Klaus, Jochen, Kleczkowski, Dariusz, Klopocka, Maria, Kobayashi, Taku, Kobielusz-gembala, Iwona, Kojima, Yuichiro, Koo, Ja Seol, Kopon, Adam, Kopp, James, Koyama, Fumikazu, Koynarski, Vasil, Kravchenko, Tetiana, Kudo, Masatoshi, Kusunoki, Ryusaku, Kwon, Kwangan, Laclav, Martin, Lago, Paula, Laharie, David, Lasa, Juan, Lateef, Syed, Latinovic Radakovic, Tatjana, Lee, Kang Moon, Leszczyszyn, Jaroslaw, Li, Yan, Liu, Mei, Liu, Eashen, Lobaton Ortega, Triana, Lopatin, Denis, Lopes, Susana, Lovric Jovanovic, Mileva, Lubini, Marcio, Lukas, Milan, Maaser, Christian, Machytka, Evzen, Maemoto, Atsuo, Magro, Fernando, Marcet, Jorge, Marini, Eduardo, Marusawa, Hiroyuki, Matous, Jan, Matsumoto, Takayuki, Mendu, Shoba, Miao, Yinglei, Mihaly, Emese, Miheller, Pal, Ministro, Paula, Miyabayashi, Hideharu, Mohl, Wolfgang, Molnar, Martin, Moore, Gregory, Moran Faienzo, Gabriela, Morral, Eugeni Domenech, Motoya, Satoshi, Murali, Narayanachar, Mustaffa, Nazri Mohamad, Naem, Mohamed, Nakai, Katsuhiko, Nakajima, Koichi, Nakamoto, Yasunari, Nakamura, Masanao, Nancey, Stephane, Navaneethan, Udayakumar, Nawawi, Khairul Najmi Muhammad, Ninomiya, Tomoyuki, Novak, Janos, Oki, Motoji, Oliveira Santana, Genoile, Onizawa, Michio, Ono, Yohei, Osada, Taro, Osipenko, Marina, Owczarek, Danuta, Parente, Jose Miguel, Patel, Kamal, Patel, Bhaktasharan, Pedersen, Peder, Petroniene, Rima, Petrov, Asen, Petrova, Elina, Piquet, Marie-astrid, Pokrotnieks, Juris, Poroshina, Elena, Portela, Francisco, Pruthi, Jatinder S., Prystupa, Lyudmila, Pukitis, Aldis, Qiu, Yun, Rafalsky, Vladimir, Rainis, Tova, Ramos Junior, Odery, Rashid, Mohammed, Rayyan, Yasser, Reshetko, Olga, Ribeiro, Tarsila, Rivero, Montserrat, Roblin, Xavier, Romatowski, Jacek, Rowbotham, David, Ruffinengo, Orlando Enrique, Rydzewska-wyszkowska, Grazyna, Sablin, Oleg, Sai, Souken, Saibeni, Simone, Said, Rosaida Hj. Md., Sakuraba, Hirotake, Samaan, Mark, Sandborn, William, Saruta, Masayuki, Sauk, Jenny, Savarino, Edoardo Vincenzo, Schultz, Michael, Schulze, Joerg, Sedghi, Shahriar, Seidler, Ursula, Seksik, Philippe, Senturk, Omer, Shelton, Edward, Shimizu, Masahito, Shin, Sungjae, Shukla, Richa, Sigal, Michael, Silva Junior, Roberto, Simoes Neto, Joaquim, Siroky Jr., Milan, Smajstrla, Vit, Smid, Vaclav, Smiley, Sarah, Soledad Brunatto, Luciana, Stanislavchuk, Mykola, Stokesberry, David, Stone, Christian, Suiter, Daniel, Suzuki, Takayoshi, Svorcan, Petar, Takagi, Sho, Takagi, Tomohisa, Takamura, Masaaki, Takayama, Tetsuji, Takeuchi, Ken, Tanaka, Akihito, Tanaka, Hiroki, Tanash, Omar, Tang, Wen, Tankova, Ludmila, Teixeira Campos, Luciana, Thin, Lena, Tkachev, Alexander, Tolmanis, Ivars, Tsarynna, Nataliia, Tsonev, Nikolay, Tulassay, Zsolt, Ueo, Tetsuya, Unal, Nalan, Valuyskikh, Ekaterina, Van Dop, Willemijn, Vasilevskaya, Olga, Venugopal, Kannan, Verstockt, Bram, Viamonte, Manuel, Vyshyvanyuk, Vira, Wang, Bangmao, Wang, Xiaoyan, Wang, Jiangbin, Wang, Yufang, Wei, Shu-chen, Weisshof, Roni, Wisam, Sbeit, Wojcik, Katarzyna, Yakovlev, Alexey, Yasuda, Hiroshi, Ye, Byongduk, Yen, Hsu-heng, Yilmaz, Hasan, Yokoyama, Yoko, Yoon, Hyuk, Yoshida, Takeshi, Yurkiv, Andriy, Zaha, Osamu, Zaltman, Cyrla, Zhan, Qiang, Zhang, Hongjie, Zhang, Shutian, Zhu, Lanxiang, Zou, Duowu, Zou, Xiaoping, Zureikat, Firas, Rubin, David T, Allegretti, Jessica R, Panés, Julián, Shipitofsky, Nicole, Yarandi, Shadi S, Huang, Kuan-Hsiang Gary, Germinaro, Matthew, Wilson, Rebbecca, Zhang, Hongyan, Johanns, Jewel, Feagan, Brian G, Hisamatsu, Tadakazu, Lichtenstein, Gary R, Bressler, Brian, Peyrin-Biroulet, Laurent, Sands, Bruce E, and Dignass, Axel
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- 2025
- Full Text
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3. Long time consequences after STARR procedure: Report of 15 years experience and medico-legal perspective
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Andreoli, Remo, Zampieri, Nicola, Orlandi, Simone, Geccherle, Andrea, and Castellani, Roberto L.
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- 2024
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4. Switching from VEDOlizumab intravenous to subcutaneous formulation in ulcerative colitis patients in clinical remission: The SVEDO Study, an IG-IBD study
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Ribaldone, Davide Giuseppe, Parisio, Laura, Variola, Angela, Bossa, Fabrizio, Castiglione, Fabiana, Marzo, Manuela, Piazza, Nicole, Aratari, Annalisa, Savarino, Edoardo Vincenzo, Bodini, Giorgia, Mastronardi, Mauro, Micheli, Federica, Mazzuoli, Silvia, Ascolani, Marta, Viganò, Chiara, Cappello, Maria, Bezzio, Cristina, Ciccocioppo, Rachele, Scardino, Giulia, Sarli, Ennio, Pugliese, Daniela, Scaldaferri, Franco, Napolitano, Daniele, Todeschini, Alessia, Geccherle, Andrea, Colaci, Nicoletta, Guerra, Maria, Annese, Monica, Testa, Anna, Caiazzo, Anna, Conforti, Francesco Simone, Festa, Stefano, Lorenzon, Greta, Marra, Antonella, Magiotta, Ambra, Baccini, Flavia, Amato, Arnaldo, Poshnjari, Anxhela, Vernero, Marta, Caprioli, Flavio, and Caviglia, Gian Paolo
- Published
- 2024
- Full Text
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5. Correction to: Surgical treatment of colonic Crohn’s disease: a national snapshot study
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Celentano, Valerio, Pellino, Gianluca, Rottoli, Matteo, Poggioli, Gilberto, Sica, Giuseppe, Giglio, Mariano Cesare, Campanelli, Michela, Coco, Claudio, Rizzo, Gianluca, Sionne, Francesco, Colombo, Francesco, Sampietro, Gianluca, Lamperti, Giulia, Foschi, Diego, Ficari, Ferdinando, Vacca, Ludovica, Cricchio, Marta, Giudici, Francesco, Selvaggi, Lucio, Sciaudone, Guido, Peltrini, Roberto, Manfreda, Andrea, Bucci, Luigi, Galleano, Raffaele, Ghazouani, Omar, Zorcolo, Luigi, Deidda, Simona, Restivo, Angelo, Braini, Andrea, Di Candido, Francesca, Sacchi, Matteo, Carvello, Michele, Martorana, Stefania, Bordignon, Giovanni, Angriman, Imerio, Variola, Angela, Barugola, Giuliano, Di Ruscio, Mirko, Tanzanu, Marta, Geccherle, Andrea, Tropeano, Francesca Paola, Luglio, Gaetano, Sasia, Diego, Migliore, Marco, Giuffrida, Maria Carmela, Marrano, Enrico, Moretto, Gianluigi, Impellizzeri, Harmony, Gallo, Gaetano, Vescio, Giuseppina, Sammarco, Giuseppe, Terrosu, Giovanni, Calini, Giacomo, Bondurri, Andrea, Maffioli, Anna, Zaffaroni, Gloria, Resegotti, Andrea, Mistrangelo, Massimiliano, Allaix, Marco Ettore, Botti, Fiorenzo, Prati, Matteo, Boni, Luigi, Perotti, Serena, Mineccia, Michela, Giuliani, Antonio, Romano, Lucia, Graziano, Giorgio Maria Paolo, Pugliese, Luigi, Pietrabissa, Andrea, Delaini, GianGaetano, Spinelli, Antonino, and Selvaggi, Francesco
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- 2022
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6. Treat to target versus standard of care for patients with Crohn's disease treated with ustekinumab (STARDUST): an open-label, multicentre, randomised phase 3b trial
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Rocca, Rodolfo, Lopes, Susana, Caprioli, Flavio, Ardizzone, Sandro, Echarri Piudo, Ana, Gionchetti, Paolo, Roblin, Xavier, Seidler, Ursula, Andersson, David, Patel, Kamal, Desreumaux, Pierre, Saibeni, Simone, From, Gustav, Fedurco, Miroslav, Gregus, Milos, Bouhnik, Yoram, Luegering, Andreas, Cosintino, Rocco, Bunganic, Ivan, Ramos, Jaime, Aguas Peris, Mariam, Dewit, Olivier, Principi, Mariabeatrice, Wesley, Emma, Lago, Paula, Nancey, Stephane, Martín Arranz, María Dolores, Hindryckx, Pieter, Orlando, Ambrogio, Geccherle, Andrea, Annunziata, Maria Laura, Hayee, Bu'hussain, Balaz, Jozef, Portela, Francisco, Gilletta, Cyrielle, Kucharzik, Torsten, Mínguez, Miguel, Gisbert, Javier Pérez, Casbas, Ana Gutiérrez, Louis, Edouard, Marino, Marco, Parkes, Gareth, Cummings, Fraser, Jharap, Bindia, Kjeldsen, Jens, Correia, Luís, Ministro, Paula, Ebert, Matthias, Hertervig, Erik, Staessen, Dirk, Dutré, Joris, Colard, Arnaud, Morrison, Graham, Glerup, Henning, Dahlerup, Jens Frederik, Wolfhagen, Frank, Batovsky, Marian, Molnar, Martin, Kadleckova, Barbora, Caldeira, Paulo, Laharie, David, Hebuterne, Xavier, Bonaz, Bruno, Allez, Matthieu, Fischer, Andreas, Hinojosa Del Val, Joaquín Ernesto, Ciria, Miriam Mañosa, Herrera Justiniano, Jose Manuel, Soderman, Charlotte, Chandy, Rajiv, Mowat, Craig, Irving, Peter, Fallingborg, Jan, Matous, Jan, Douda, Tomas, Altwegg, Romain, Benitez, Jose Manuel, Arroyo Villarino, María Teresa, Capón, Jordi Guardiola, Vicenc, Daniel Ginard, Dewint, Pieter, Almer, Sven, Kindt, Sebastien, Danese, Silvio, Vermeire, Severine, D'Haens, Geert, Panés, Julian, Dignass, Axel, Magro, Fernando, Nazar, Maciej, Le Bars, Manuela, Lahaye, Marjolein, Ni, Lioudmila, Bravata, Ivana, Lavie, Frederic, Daperno, Marco, Lukáš, Milan, Armuzzi, Alessandro, Löwenberg, Mark, Gaya, Daniel R, and Peyrin-Biroulet, Laurent
- Published
- 2022
- Full Text
- View/download PDF
7. Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies
- Author
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Rubin, David T, Allegretti, Jessica R, Panés, Julián, Shipitofsky, Nicole, Yarandi, Shadi S, Huang, Kuan-Hsiang Gary, Germinaro, Matthew, Wilson, Rebbecca, Zhang, Hongyan, Johanns, Jewel, Feagan, Brian G, Hisamatsu, Tadakazu, Lichtenstein, Gary R, Bressler, Brian, Peyrin-Biroulet, Laurent, Sands, Bruce E, Dignass, Axel, Abrahamovych, Orest, Abu-farsakh, Niazy, Afanasieva, Halyna, Akpinar, Hale, Al Kharrat, Houssam, Altintas, Engin, Altwegg, Romain, Andreev, Pavel, Aomatsu, Kazuki, Araki, Hiroshi, Argollo, Marjorie, Ariel, Federico, Armuzzi, Alessandro, Ashida, Toshifumi, Augustyn, Monika, Aumais, Guy, Azum, Martín, Baert, Filip, Balaz, Jozef, Balderramo, Domingo, Begun, Jakob, Berova, Temenuzhka, Billiauws, Lore, Blanco, Antonio, Bortlik, Martin, Bossa, Fabrizio, Bunkova, Elena, Cabello, Mercedes, Cao, Qian, Caprioli, Flavio, Cerqueira, Rute, Chachu, Karen, Chamouard, Patrick, Chen, Chunxiao, Chen, Yan, Chen, Baili, Chen, Dongfeng, Chen, Hong, Chen, Youxiang, Chen, Chou-chen, Cheon, Jaehee, Chen, Minhu, Chiu, Cheng-tang, Choi, Changhwan, Chow, Elizabeth, Cicala, Michele, Cintra, Aderson, Danilkiewicz, Wit, Datsenko, Olena, De Hertogh, Gert, De María, Julio, Del Valle Torrealba Medina, Leyanira, Deliang, Liu, Desreumaux, Pierre, Dewint, Pieter, Ding, Shigang, Doherty, Glen, Draganova, Raina, Dutré, Joris, Duvall, George, Egan, Laurence, Fahed, Julien, Fechner, Lars, Fedurco, Miroslav, Ferhat Celik, Aykut, Fernandez, Juan, Filip, Rafal, Fishman, Sigal, Flores, Cristina, Fogel, Ronald, Fowler, Sharyle, Francesconi, Carlos, Fujii, Toshimitsu, Fujiya, Mikihiro, Fukata, Masayuki, Fukuhara, Seiichiro, Furumoto, Yohei, G.Kiss, Gyula, Gachowski, Waldemar, Gao, Xiang, Gasbarrini, Antonio, Gawdis-wojnarska, Beata, Gaya, Daniel, Geccherle, Andrea, Gilletta De Saint Joseph, Cyrielle, Gimenez, Edgardo, Gionchetti, Paolo, Goldin, Eran, Golovchenko, Oleksandr, Gonciarz, Maciej, Gonen, Can, Gonzales, Chad, Gonzalez, Raquel, Gonzalez Segura, Gaston Julian, Gridnyev, Oleksiy, Gu, Fang, Gupta, Nitin, Gyokeres, Tibor, Haines, Melissa, Hebuterne, Xavier, Hedin, Charlotte, Hellstrom, Per, Hilmi, Ida Normiha, Hirai, Fumihito, Hisabe, Takashi, Hlavaty, Tibor, Hoentjen, Frank, Holtmann, Gerald, Horiki, Noriyuki, Horny, Ivo, Horvat, Gyula, Horvath, Frantisek, Hoshi, Namiko, Hosomi, Shuhei, Hospodarskyy, Ihor, Hou, Xiaohua, Hrdlicka, Ludek, Hu, Naizhong, Huang, Vivian, Huang, Caibin, Inaba, Tomoki, Ishiguro, Yoh, Ishihara, Shunji, Ishikawa, Takeshi, Iskandar, Heba, Israeli, Eran, Itaba, Soichi, Ivanishyn, Olha, Izbéki, Ferenc, Jain, Animesh, Jairath, Vipul, Jang, Byung Ik, Jiang, Chunmeng, Jones, Michael, Kagaya, Takashi, Kalimullina, Dilara, Karakina, Marina, Karatas, Ali, Kashimura, Hiroshi, Keret, Dan, Khovaeva, Yaroslava, Kierkus, Jaroslaw, Kim, Taeoh, Kim, Youngho, Kim, Hyo Jong, Klaus, Jochen, Kleczkowski, Dariusz, Klopocka, Maria, Kobayashi, Taku, Kobielusz-gembala, Iwona, Kojima, Yuichiro, Koo, Ja Seol, Kopon, Adam, Kopp, James, Koyama, Fumikazu, Koynarski, Vasil, Kravchenko, Tetiana, Kudo, Masatoshi, Kusunoki, Ryusaku, Kwon, Kwangan, Laclav, Martin, Lago, Paula, Laharie, David, Lasa, Juan, Lateef, Syed, Latinovic Radakovic, Tatjana, Lee, Kang Moon, Leszczyszyn, Jaroslaw, Li, Yan, Liu, Mei, Liu, Eashen, Lobaton Ortega, Triana, Lopatin, Denis, Lopes, Susana, Lovric Jovanovic, Mileva, Lubini, Marcio, Lukas, Milan, Maaser, Christian, Machytka, Evzen, Maemoto, Atsuo, Magro, Fernando, Marcet, Jorge, Marini, Eduardo, Marusawa, Hiroyuki, Matous, Jan, Matsumoto, Takayuki, Mendu, Shoba, Miao, Yinglei, Mihaly, Emese, Miheller, Pal, Ministro, Paula, Miyabayashi, Hideharu, Mohl, Wolfgang, Molnar, Martin, Moore, Gregory, Moran Faienzo, Gabriela, Morral, Eugeni Domenech, Motoya, Satoshi, Murali, Narayanachar, Mustaffa, Nazri Mohamad, Naem, Mohamed, Nakai, Katsuhiko, Nakajima, Koichi, Nakamoto, Yasunari, Nakamura, Masanao, Nancey, Stephane, Navaneethan, Udayakumar, Nawawi, Khairul Najmi Muhammad, Ninomiya, Tomoyuki, Novak, Janos, Oki, Motoji, Oliveira Santana, Genoile, Onizawa, Michio, Ono, Yohei, Osada, Taro, Osipenko, Marina, Owczarek, Danuta, Parente, Jose Miguel, Patel, Kamal, Patel, Bhaktasharan, Pedersen, Peder, Petroniene, Rima, Petrov, Asen, Petrova, Elina, Piquet, Marie-astrid, Pokrotnieks, Juris, Poroshina, Elena, Portela, Francisco, Pruthi, Jatinder S., Prystupa, Lyudmila, Pukitis, Aldis, Qiu, Yun, Rafalsky, Vladimir, Rainis, Tova, Ramos Junior, Odery, Rashid, Mohammed, Rayyan, Yasser, Reshetko, Olga, Ribeiro, Tarsila, Rivero, Montserrat, Roblin, Xavier, Romatowski, Jacek, Rowbotham, David, Ruffinengo, Orlando Enrique, Rydzewska-wyszkowska, Grazyna, Sablin, Oleg, Sai, Souken, Saibeni, Simone, Said, Rosaida Hj. Md., Sakuraba, Hirotake, Samaan, Mark, Sandborn, William, Saruta, Masayuki, Sauk, Jenny, Savarino, Edoardo Vincenzo, Schultz, Michael, Schulze, Joerg, Sedghi, Shahriar, Seidler, Ursula, Seksik, Philippe, Senturk, Omer, Shelton, Edward, Shimizu, Masahito, Shin, Sungjae, Shukla, Richa, Sigal, Michael, Silva Junior, Roberto, Simoes Neto, Joaquim, Siroky Jr., Milan, Smajstrla, Vit, Smid, Vaclav, Smiley, Sarah, Soledad Brunatto, Luciana, Stanislavchuk, Mykola, Stokesberry, David, Stone, Christian, Suiter, Daniel, Suzuki, Takayoshi, Svorcan, Petar, Takagi, Sho, Takagi, Tomohisa, Takamura, Masaaki, Takayama, Tetsuji, Takeuchi, Ken, Tanaka, Akihito, Tanaka, Hiroki, Tanash, Omar, Tang, Wen, Tankova, Ludmila, Teixeira Campos, Luciana, Thin, Lena, Tkachev, Alexander, Tolmanis, Ivars, Tsarynna, Nataliia, Tsonev, Nikolay, Tulassay, Zsolt, Ueo, Tetsuya, Unal, Nalan, Valuyskikh, Ekaterina, Van Dop, Willemijn, Vasilevskaya, Olga, Venugopal, Kannan, Verstockt, Bram, Viamonte, Manuel, Vyshyvanyuk, Vira, Wang, Bangmao, Wang, Xiaoyan, Wang, Jiangbin, Wang, Yufang, Wei, Shu-chen, Weisshof, Roni, Wisam, Sbeit, Wojcik, Katarzyna, Yakovlev, Alexey, Yasuda, Hiroshi, Ye, Byongduk, Yen, Hsu-heng, Yilmaz, Hasan, Yokoyama, Yoko, Yoon, Hyuk, Yoshida, Takeshi, Yurkiv, Andriy, Zaha, Osamu, Zaltman, Cyrla, Zhan, Qiang, Zhang, Hongjie, Zhang, Shutian, Zhu, Lanxiang, Zou, Duowu, Zou, Xiaoping, and Zureikat, Firas
- Abstract
Interleukin-23 inhibition is effective in treating ulcerative colitis. Guselkumab is a dual-acting, human IgG1, interleukin-23p19 subunit inhibitor that potently neutralises interleukin-23 and can bind to CD64. We aimed to evaluate the efficacy and safety of guselkumab as induction and maintenance therapy in patients with ulcerative colitis.
- Published
- 2025
- Full Text
- View/download PDF
8. Anastomosis configuration and technique following ileocaecal resection for Crohn’s disease: a multicentre study
- Author
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Celentano, Valerio, Pellino, Gianluca, Spinelli, Antonino, Selvaggi, Francesco, Celentano, Valerio, Pellino, Gianluca, Rottoli, Matteo, Poggioli, Gilberto, Sica, Giuseppe, Giglio, Mariano Cesare, Campanelli, Michela, Coco, Claudio, Rizzo, Gianluca, Sionne, Francesco, Colombo, Francesco, Sampietro, Gianluca, Lamperti, Giulia, Foschi, Diego, Ficari, Ferdinando, Vacca, Ludovica, Cricchio, Marta, Giudici, Francesco, Selvaggi, Lucio, Sciaudone, Guido, Peltrini, Roberto, Manfreda, Andrea, Bucci, Luigi, Galleano, Raffaele, Ghazouani, Omar, Zorcolo, Luigi, Deidda, Simona, Restivo, Angelo, Braini, Andrea, Di Candido, Francesca, Sacchi, Matteo, Carvello, Michele, Martorana, Stefania, Bordignon, Giovanni, Angriman, Imerio, Variola, Angela, Di Ruscio, Mirko, Barugola, Giuliano, Geccherle, Andrea, Tropeano, Francesca Paola, Luglio, Gaetano, Tanzanu, Marta, Sasia, Diego, Migliore, Marco, Giuffrida, Maria Carmela, Marrano, Enrico, Moretto, Gianluigi, Impellizzeri, Harmony, Gallo, Gaetano, Vescio, Giuseppina, Sammarco, Giuseppe, Terrosu, Giovanni, Calini, Giacomo, Bondurri, Andrea, Maffioli, Anna, Zaffaroni, Gloria, Resegotti, Andrea, Mistrangelo, Massimiliano, Allaix, Marco Ettore, Botti, Fiorenzo, Prati, Matteo, Boni, Luigi, Perotti, Serena, Mineccia, Michela, Giuliani, Antonio, Romano, Lucia, Graziano, Giorgio Maria Paolo, Pugliese, Luigi, Pietrabissa, Andrea, Delaini, GianGaetano, Spinelli, Antonino, and Selvaggi, Francesco
- Published
- 2021
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- View/download PDF
9. Use of biosimilars in inflammatory bowel disease: a position update of the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD)
- Author
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Leone, Salvatore, Previtali, Enrica, Aloi, Marina, Alvisi, Patrizia, Antonelli, Elisabetta, Ardizzone, Sandro, Astegiano, Marco, Baldoni, Monia, Beltrami, Marina, Biancone, Livia, Bodini, Giorgia, Buda, Andrea, Bossa, Fabrizio, Bracci, Fiammetta, Calabrese, Emma, Cappello, Maria, Castiglione, Fabiana, Ciacci, Carolina, Cicala, Michele, Ciccocioppo, Rachele, Comberlato, Michele, Cortelezzi, Claudio Camillo, Cosintino, Rocco, Costa, Francesco, Costantino, Giuseppe, Cucchiara, Salvatore, Cuomo, Antonio, D’Incà, Renata, Di Paolo, Maria Carla, Di Sabatino, Antonio, Di Sario, Antonio, Frieri, Giuseppe, Fries, Walter, Gasbarrini, Antonio, Geccherle, Andrea, Gionchetti, Paolo, Graziani, Maria Giovanna, Grossi, Laurino, Guidi, Luisa, Imperiali, Gianni, Latella, Giovanni, Lionetti, Paolo, Inserra, Gaetano, Maconi, Giovanni, Manguso, Francesco, Marino, Marco, Mastronardi, Mauro, Mazzuoli, Silvia, Meucci, Gianmichele, Mendolaro, Marco, Milla, Monica, Mocci, Giammarco, Monteleone, Giovanni, Bortoluzzi, Francesco Neri, Pagnini, Cristiano, Pastorelli, Luca, Pica, Roberta, Piergallini, Simona, Privitera, Antonello, Renna, Sara, Ribaldone, Davide Giuseppe, Ricci, Chiara, Rispo, Antonio, Rocca, Rodolfo, Romano, Claudio, Romano, Marco, Russo, Giovanni, Sablich, Renato, Saibeni, Simone, Savarino, Edoardo, Scribano, Maria Lia, Spagnuolo, Rocco, Stasi, Elisa, Terpin, Maria Maddalena, Testa, Anna, Valpiani, Daniela, Variola, Angela, Vernia, Piero, Vitale, Giovanna, Zoli, Giorgio, Fiorino, Gionata, Caprioli, Flavio, Daperno, Marco, Mocciaro, Filippo, Principi, Mariabeatrice, Viscido, Angelo, Fantini, Massimo Claudio, Orlando, Ambrogio, Papi, Claudio, Annese, Vito, Danese, Silvio, Vecchi, Maurizio, Rizzello, Fernando, and Armuzzi, Alessandro
- Published
- 2019
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10. Long time consequences after STARR procedure: Report of 15 years experience and medico-legal perspective
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Andreoli, Remo, primary, Zampieri, Nicola, additional, Orlandi, Simone, additional, Geccherle, Andrea, additional, and Castellani, Roberto L., additional
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- 2023
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11. A Challenging Colectomy for Acute Severe Ulcerative Colitis Complicated by COVID-19
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Di Ruscio, Mirko, Variola, Angela, Angheben, Andrea, Resimini, Silvia, Geccherle, Andrea, Ruffo, Giacomo, and Barugola, Giuliano
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- 2020
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12. Switching from VEDOlizumab intravenous to subcutaneous formulation in ulcerative colitis patients in clinical remission: The SVEDO Study, an IG-IBD study
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Ribaldone, Davide Giuseppe, primary, Parisio, Laura, additional, Variola, Angela, additional, Bossa, Fabrizio, additional, Castiglione, Fabiana, additional, Marzo, Manuela, additional, Piazza, Nicole, additional, Aratari, Annalisa, additional, Savarino, Edoardo Vincenzo, additional, Bodini, Giorgia, additional, Mastronardi, Mauro, additional, Micheli, Federica, additional, Mazzuoli, Silvia, additional, Ascolani, Marta, additional, Viganò, Chiara, additional, Cappello, Maria, additional, Bezzio, Cristina, additional, Ciccocioppo, Rachele, additional, Scardino, Giulia, additional, Sarli, Ennio, additional, Pugliese, Daniela, additional, Scaldaferri, Franco, additional, Napolitano, Daniele, additional, Todeschini, Alessia, additional, Geccherle, Andrea, additional, Colaci, Nicoletta, additional, Guerra, Maria, additional, Annese, Monica, additional, Testa, Anna, additional, Caiazzo, Anna, additional, Conforti, Francesco Simone, additional, Festa, Stefano, additional, Lorenzon, Greta, additional, Marra, Antonella, additional, Magiotta, Ambra, additional, Baccini, Flavia, additional, Amato, Arnaldo, additional, Poshnjari, Anxhela, additional, Vernero, Marta, additional, Caprioli, Flavio, additional, and Caviglia, Gian Paolo, additional
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- 2023
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13. The PROSIT Cohort of Infliximab Biosimilar in IBD: A Prolonged Follow-up on the Effectiveness and Safety Across Italy
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Armuzzi, Alessandro, Fiorino, Gionata, Variola, Angela, Manetti, Natalia, Fries, Walter, Orlando, Ambrogio, Maconi, Giovanni, Bossa, Fabrizio, Cappello, Maria, Biancone, Livia, Cantoro, Laura, Costa, Francesco, D’Incà, Renata, Lionetti, Paolo, Principi, Mariabeatrice, Castiglione, Fabiana, Annunziata, Maria L, Di Sabatino, Antonio, Di Girolamo, Maria, Terpin, Maria M, Cortelezzi, Claudio C, Saibeni, Simone, Amato, Arnaldo, Ardizzone, Sandro, Guidi, Luisa, Danese, Silvio, Massella, Arianna, Ventra, Agostino, Rizzuto, Giulia, Massari, Alessandro, Perri, Francesco, Annese, Vito, Saettone, Silvia, Tari, Roberto, Petruzzellis, Carlo, Meucci, Gianmichele, Imperiali, Gianni, Guglielmi, Francesco W, Mazzuoli, Silvia, Caserta, Luigi, Caterina Parodi, Maria, Colli, Agostino, Ronchetti, Anna, Pugliese, Daniela, Geccherle, Andrea, Rogai, Francesca, Milani, Stefano, Renna, Sara, Cassinotti, Andrea, Andriulli, Angelo, Martino, Giuseppina, Scrivo, Barbara, Troncone, Edoardo, Kohn, Anna, Bertani, Lorenzo, Lorenzon, Greta, Ghione, Silvia, Nardone, Olga, Vecchi, Maurizio, Bertani, Angela, Bosani, Matteo A, Bezzio, Cristina, and Salerno, Raffaele
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- 2019
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14. Long-term results and quality of life in patients treated with hemorrhoidectomy using two different techniques: Ligasure versus transanal hemorrhoidal dearterialization
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Zampieri, Nicola, Castellani, Roberto, Andreoli, Remo, and Geccherle, Andrea
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- 2012
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15. Treat to target versus standard of care for patients with Crohn's disease treated with ustekinumab (STARDUST):an open-label, multicentre, randomised phase 3b trial
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Danese, Silvio, Vermeire, Severine, D'Haens, Geert, Panés, Julian, Dignass, Axel, Magro, Fernando, Nazar, Maciej, Le Bars, Manuela, Lahaye, Marjolein, Ni, Lioudmila, Bravata, Ivana, Lavie, Frederic, Daperno, Marco, Lukáš, Milan, Armuzzi, Alessandro, Löwenberg, Mark, Gaya, Daniel R., Peyrin-Biroulet, Laurent, Rocca, Rodolfo, Lopes, Susana, Caprioli, Flavio, Ardizzone, Sandro, Echarri Piudo, Ana, Gionchetti, Paolo, Roblin, Xavier, Seidler, Ursula, Andersson, David, Patel, Kamal, Desreumaux, Pierre, Saibeni, Simone, From, Gustav, Fedurco, Miroslav, Gregus, Milos, Bouhnik, Yoram, Luegering, Andreas, Cosintino, Rocco, Bunganic, Ivan, Ramos, Jaime, Aguas Peris, Mariam, Dewit, Olivier, Principi, Mariabeatrice, Wesley, Emma, Lago, Paula, Nancey, Stephane, Martín Arranz, María Dolores, Hindryckx, Pieter, Orlando, Ambrogio, Geccherle, Andrea, Annunziata, Maria Laura, Danese, Silvio, Vermeire, Severine, D'Haens, Geert, Panés, Julian, Dignass, Axel, Magro, Fernando, Nazar, Maciej, Le Bars, Manuela, Lahaye, Marjolein, Ni, Lioudmila, Bravata, Ivana, Lavie, Frederic, Daperno, Marco, Lukáš, Milan, Armuzzi, Alessandro, Löwenberg, Mark, Gaya, Daniel R., Peyrin-Biroulet, Laurent, Rocca, Rodolfo, Lopes, Susana, Caprioli, Flavio, Ardizzone, Sandro, Echarri Piudo, Ana, Gionchetti, Paolo, Roblin, Xavier, Seidler, Ursula, Andersson, David, Patel, Kamal, Desreumaux, Pierre, Saibeni, Simone, From, Gustav, Fedurco, Miroslav, Gregus, Milos, Bouhnik, Yoram, Luegering, Andreas, Cosintino, Rocco, Bunganic, Ivan, Ramos, Jaime, Aguas Peris, Mariam, Dewit, Olivier, Principi, Mariabeatrice, Wesley, Emma, Lago, Paula, Nancey, Stephane, Martín Arranz, María Dolores, Hindryckx, Pieter, Orlando, Ambrogio, Geccherle, Andrea, and Annunziata, Maria Laura
- Abstract
Background: A treat-to-target strategy, in which strictly defined treatment targets facilitate decision making in clinical practice, is advocated as an optimised management approach for some chronic disorders. The aim of the STARDUST trial was to assess whether a treat-to-target strategy with early endoscopy, regular biomarker and clinical symptom monitoring, and dose intensification for persistent inflammatory activity, was more successful in achieving endoscopic improvement at week 48 than a clinically driven maintenance strategy in patients with moderate-to-severe active Crohn's disease receiving ustekinumab. Methods: This open-label, multicentre, randomised phase 3b trial included adults with active, moderate-to-severe Crohn's disease (Crohn's Disease Activity Index [CDAI] 220–450 and Simple Endoscopic Score in Crohn's Disease [SES-CD] ≥3) for whom conventional therapy or one biologic therapy, or both, had failed. Patients received intravenous ustekinumab approximating 6 mg/kg at baseline and subcutaneous ustekinumab 90 mg at week 8. At week 16, patients with a CDAI improvement of 70 or more points from baseline were randomly assigned (1:1) to receive standard-of-care or treat-to-target maintenance treatment through week 48. Randomisation was balanced by using randomly permuted blocks and was stratified by biologic history status and baseline SES-CD score. All patients who signed informed consent, who were not screening failures, and who received at least one dose of study treatment were included in week 16 analyses. All patients included in week 16 analyses and randomly assigned to one of the maintenance treatment regimens were included in the week 48 efficacy and safety analyses (ie, on an intention-to-treat basis). Patients assigned to the treat-to-target arm received ustekinumab every 12 weeks or every 8 weeks based on SES-CD improvement from baseline and could escalate to every 4 weeks through week 48 if prespecified targets were missed. Patients assigne
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- 2022
16. Treat to target versus standard of care for patients with Crohn's disease treated with ustekinumab (STARDUST): an open-label, multicentre, randomised phase 3b trial
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Danese, Silvio, primary, Vermeire, Severine, additional, D'Haens, Geert, additional, Panés, Julian, additional, Dignass, Axel, additional, Magro, Fernando, additional, Nazar, Maciej, additional, Le Bars, Manuela, additional, Lahaye, Marjolein, additional, Ni, Lioudmila, additional, Bravata, Ivana, additional, Lavie, Frederic, additional, Daperno, Marco, additional, Lukáš, Milan, additional, Armuzzi, Alessandro, additional, Löwenberg, Mark, additional, Gaya, Daniel R, additional, Peyrin-Biroulet, Laurent, additional, Rocca, Rodolfo, additional, Lopes, Susana, additional, Caprioli, Flavio, additional, Ardizzone, Sandro, additional, Echarri Piudo, Ana, additional, Gionchetti, Paolo, additional, Roblin, Xavier, additional, Seidler, Ursula, additional, Andersson, David, additional, Patel, Kamal, additional, Desreumaux, Pierre, additional, Saibeni, Simone, additional, From, Gustav, additional, Fedurco, Miroslav, additional, Gregus, Milos, additional, Bouhnik, Yoram, additional, Luegering, Andreas, additional, Cosintino, Rocco, additional, Bunganic, Ivan, additional, Ramos, Jaime, additional, Aguas Peris, Mariam, additional, Dewit, Olivier, additional, Principi, Mariabeatrice, additional, Wesley, Emma, additional, Lago, Paula, additional, Nancey, Stephane, additional, Martín Arranz, María Dolores, additional, Hindryckx, Pieter, additional, Orlando, Ambrogio, additional, Geccherle, Andrea, additional, Annunziata, Maria Laura, additional, Hayee, Bu'hussain, additional, Balaz, Jozef, additional, Portela, Francisco, additional, Gilletta, Cyrielle, additional, Kucharzik, Torsten, additional, Mínguez, Miguel, additional, Gisbert, Javier Pérez, additional, Casbas, Ana Gutiérrez, additional, Louis, Edouard, additional, Marino, Marco, additional, Parkes, Gareth, additional, Cummings, Fraser, additional, Jharap, Bindia, additional, Kjeldsen, Jens, additional, Correia, Luís, additional, Ministro, Paula, additional, Ebert, Matthias, additional, Hertervig, Erik, additional, Staessen, Dirk, additional, Dutré, Joris, additional, Colard, Arnaud, additional, Morrison, Graham, additional, Glerup, Henning, additional, Dahlerup, Jens Frederik, additional, Wolfhagen, Frank, additional, Batovsky, Marian, additional, Molnar, Martin, additional, Kadleckova, Barbora, additional, Caldeira, Paulo, additional, Laharie, David, additional, Hebuterne, Xavier, additional, Bonaz, Bruno, additional, Allez, Matthieu, additional, Fischer, Andreas, additional, Hinojosa Del Val, Joaquín Ernesto, additional, Ciria, Miriam Mañosa, additional, Herrera Justiniano, Jose Manuel, additional, Soderman, Charlotte, additional, Chandy, Rajiv, additional, Mowat, Craig, additional, Irving, Peter, additional, Fallingborg, Jan, additional, Matous, Jan, additional, Douda, Tomas, additional, Altwegg, Romain, additional, Benitez, Jose Manuel, additional, Arroyo Villarino, María Teresa, additional, Capón, Jordi Guardiola, additional, Vicenc, Daniel Ginard, additional, Dewint, Pieter, additional, Almer, Sven, additional, and Kindt, Sebastien, additional
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- 2022
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17. A Seroprevalence Study of Anti-SARS-CoV-2 Antibodies in Patients with Inflammatory Bowel Disease during the Second Wave of the COVID-19 Pandemic in Italy
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Di Ruscio, Mirko, primary, Lunardi, Gianluigi, additional, Buonfrate, Dora, additional, Gobbi, Federico, additional, Bertoli, Giulia, additional, Piccoli, Donatella, additional, Conti, Antonio, additional, Geccherle, Andrea, additional, and Variola, Angela, additional
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- 2021
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18. Prevalence and real-world management of vedolizumab-associated enthesitis in successfully treated IBD patients
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Ruscio, Mirko Di, primary, Tinazzi, Ilaria, additional, Variola, Angela, additional, Geccherle, Andrea, additional, Marchetta, Antonio, additional, and McGonagle, Dennis, additional
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- 2021
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19. Role of Ulcerative Colitis Endoscopic Index of Severity (UCEIS) versus Mayo Endoscopic Subscore (MES) in Predicting Patients′ Response to Biological Therapy and the Need for Colectomy
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Di Ruscio, Mirko, primary, Variola, Angela, additional, Vernia, Filippo, additional, Lunardi, Gianluigi, additional, Castelli, Paola, additional, Bocus, Paolo, additional, and Geccherle, Andrea, additional
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- 2020
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20. The IBIS-Q [IBd Identification of Spondyloarthritis Questionnaire]: A Novel Tool to Detect Both Axial and Peripheral Arthritis in Inflammatory Bowel Disease Patients
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Variola, Angela, primary, Zanolin, Maria Elisabetta, additional, Cipriano, Giovanni, additional, Macchioni, Pierluigi, additional, Martinis, Federica, additional, Pasetti, Annalisa, additional, Grassi, Mario, additional, Geccherle, Andrea, additional, Marchetta, Antonio, additional, McGonagle, Dennis, additional, and Tinazzi, Ilaria, additional
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- 2020
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21. Clinical and sonographic discrimination between fibromyalgia and spondyloarthopathy in inflammatory bowel disease with musculoskeletal pain
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Martinis, Federica, primary, Tinazzi, Ilaria, additional, Bertolini, Elena, additional, Citriniti, Giorgia, additional, Variola, Angela, additional, Geccherle, Andrea, additional, Marchetta, Antonio, additional, McGonagle, Dennis, additional, and Macchioni, Pierluigi, additional
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- 2020
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22. SAT0351 IBIS-Q (IBD IDENTIFICATION OF SPONDYLOARTHRYTIS QUESTIONNAIRE): A NEW TOOL TO DETECT SPONDYLOARTHRITIS IN INFLAMMATORY BOWEL DISEASE PATIENTS
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Tinazzi, Ilaria, primary, Variol, Angela, additional, Marchetta, Antonio, additional, Geccherle, Andrea, additional, Macchioni, Pierluigi, additional, and Mcgonagle, Dennis, additional
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- 2019
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23. THU0405 PREVALENCE OF FIBROMYALGIA IN INFLAMMATORY BOWEL DISEASE (IBD) PATIENTS: A SINGLE CENTRE OBSERVATIONAL PROSPECTIVE STUDY
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Tinazzi, Ilaria, primary, Variola, Angela, additional, Geccherle, Andrea, additional, Marchetta, Antonio, additional, and Mcgonagle, Dennis, additional
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- 2019
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24. Use of biosimilars in inflammatory bowel disease: a position update of the Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD)
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Fiorino, Gionata, primary, Caprioli, Flavio, additional, Daperno, Marco, additional, Mocciaro, Filippo, additional, Principi, Mariabeatrice, additional, Viscido, Angelo, additional, Fantini, Massimo Claudio, additional, Orlando, Ambrogio, additional, Papi, Claudio, additional, Annese, Vito, additional, Danese, Silvio, additional, Vecchi, Maurizio, additional, Rizzello, Fernando, additional, Armuzzi, Alessandro, additional, Leone, Salvatore, additional, Previtali, Enrica, additional, Aloi, Marina, additional, Alvisi, Patrizia, additional, Antonelli, Elisabetta, additional, Ardizzone, Sandro, additional, Astegiano, Marco, additional, Baldoni, Monia, additional, Beltrami, Marina, additional, Biancone, Livia, additional, Bodini, Giorgia, additional, Buda, Andrea, additional, Bossa, Fabrizio, additional, Bracci, Fiammetta, additional, Calabrese, Emma, additional, Cappello, Maria, additional, Castiglione, Fabiana, additional, Ciacci, Carolina, additional, Cicala, Michele, additional, Ciccocioppo, Rachele, additional, Comberlato, Michele, additional, Cortelezzi, Claudio Camillo, additional, Cosintino, Rocco, additional, Costa, Francesco, additional, Costantino, Giuseppe, additional, Cucchiara, Salvatore, additional, Cuomo, Antonio, additional, D’Incà, Renata, additional, Di Paolo, Maria Carla, additional, Di Sabatino, Antonio, additional, Di Sario, Antonio, additional, Frieri, Giuseppe, additional, Fries, Walter, additional, Gasbarrini, Antonio, additional, Geccherle, Andrea, additional, Gionchetti, Paolo, additional, Graziani, Maria Giovanna, additional, Grossi, Laurino, additional, Guidi, Luisa, additional, Imperiali, Gianni, additional, Latella, Giovanni, additional, Lionetti, Paolo, additional, Inserra, Gaetano, additional, Maconi, Giovanni, additional, Manguso, Francesco, additional, Marino, Marco, additional, Mastronardi, Mauro, additional, Mazzuoli, Silvia, additional, Meucci, Gianmichele, additional, Mendolaro, Marco, additional, Milla, Monica, additional, Mocci, Giammarco, additional, Monteleone, Giovanni, additional, Bortoluzzi, Francesco Neri, additional, Pagnini, Cristiano, additional, Pastorelli, Luca, additional, Pica, Roberta, additional, Piergallini, Simona, additional, Privitera, Antonello, additional, Renna, Sara, additional, Ribaldone, Davide Giuseppe, additional, Ricci, Chiara, additional, Rispo, Antonio, additional, Rocca, Rodolfo, additional, Romano, Claudio, additional, Romano, Marco, additional, Russo, Giovanni, additional, Sablich, Renato, additional, Saibeni, Simone, additional, Savarino, Edoardo, additional, Scribano, Maria Lia, additional, Spagnuolo, Rocco, additional, Stasi, Elisa, additional, Terpin, Maria Maddalena, additional, Testa, Anna, additional, Valpiani, Daniela, additional, Variola, Angela, additional, Vernia, Piero, additional, Vitale, Giovanna, additional, and Zoli, Giorgio, additional
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- 2019
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25. Role of Ulcerative Colitis Endoscopic Index of Severity (UCEIS) versus Mayo Endoscopic Subscore (MES) in Predicting Patients′ Response to Biological Therapy and the Need for Colectomy.
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Di Ruscio, Mirko, Variola, Angela, Vernia, Filippo, Lunardi, Gianluigi, Castelli, Paola, Bocus, Paolo, and Geccherle, Andrea
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ULCERATIVE colitis ,BIOTHERAPY ,PROGNOSIS ,COLECTOMY ,COMORBIDITY - Abstract
Background: The main goal in the treatment of ulcerative colitis (UC) is to achieve mucosal healing. Despite being unvalidated, the most widely used scoring system is the Mayo endoscopic subscore (MES). However, the recently established and validated Ulcerative Colitis Endoscopic Index of Severity (UCEIS) represents an interesting alternative method in assessing endoscopic disease activity. Objective: Due to a lack of reliable prognostic factors, the aim of this study was to investigate the diagnostic accuracy of the UCEIS and the MES, in predicting response to biological therapy and the need for colectomy. Methods: We conducted a retrospective, uncontrolled, single-center study on UC patients with endoscopically active disease even with concomitant conventional and/or biological therapy, who had already started or had been changed a biological treatment. Results: Sixty-one UC patients were enrolled. At baseline, 71% were naive to biological therapies and 41% had an extensive colitis. At control time (median time of 11.5 months), MES and UCEIS scores significantly decreased from those at baseline (from 2.6 to 1.8 and 5 to 3.2, respectively, p < 0.001). UCEIS, but not MES, was found to be significantly associated with unresponsiveness to therapy (p = 0.040). Moreover, when UCEIS was ≥7, all patients underwent colectomy after a median time of 5 months (p < 0.001). Conclusion: UCEIS may be superior to MES because of its accuracy and predictive role. Therefore, UCEIS should be considered for use in daily clinical practice. [ABSTRACT FROM AUTHOR]
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- 2021
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26. Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation-predominant irritable bowel syndrome and functional constipation
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Neri, L., Iovino, P., Altomare, Donato Francesco, Annese, Vito, Badiali, Danilo, Basilisco, Guido, Bassotti, Gabrio, Battaglia, Edda, Bazzocchi, Gabriele, Bellini, Massimo, Bendia, Emanuele, Benini, Luigi, Biscaglia, Giuseppe, Biviano, Ivano, Bocchini, Renato, Bonventre, Sebastiano, Bossa, Fabrizio, Brandimarte, Giovanni, Cannizzaro, Renato, Cicala, Michele, Cipolletta, Livio, Clara, Virgilio, Cogliandro, Rosanna, Comandini, Giulia, Corazziari, Enrico, Crotta, Sergio, Cuomo, Rosario, D'Alba, Lucia, De Giorgi, Francesco, Del Piano, Mario, Di Fonzo, Michela, Di Mario, Francesco, Di Stefano, Michele, D'Onofrio, Vittorio, Efthymakis, Kostantinos, Fiore, Pierluigi, Fortuna, Manuela, Fries, Walter, Gaetani, Eleonora, Galeazzi, Francesca, Gasbarrini, Antonio, Geccherle, Andrea, Giangregorio, Francesco, Girardi, Lisa, Grassini, Mario, Groppo, Marzia, Guarnieri, Giovanni, Lo Cascio, Massimiliano, Lolli, Roberto, Luzza, Francesco, Macarri, Giampiero, Marino, Maria, Miraglia, Stefania, Monastra, Santo, Neri, Maria Cristina, Neri, Matteo, Noris, Roberto Antonio, Orselli, Silvia, Passaretti, Sandro, Paviotti, Alberto, Pazzi, Paolo, Pilotto, Alberto, Portincasa, Piero, Ranaldo, Nunzio, Ravelli, Paolo, Rogai, Francesca, Sablich, Renato, Savarino, Vincenzo, Spinzi, Giancarlo, Stanghellini, Vincenzo, Tammaro, Leonardo, Torresan, Francesco, Usai Satta, Paolo, Valle, C. Claudio, Neri, L., Iovino, P., Altomare, Donato Francesco, Annese, Vito, Badiali, Danilo, Basilisco, Guido, Bassotti, Gabrio, Battaglia, Edda, Bazzocchi, Gabriele, Bellini, Massimo, Bendia, Emanuele, Benini, Luigi, Biscaglia, Giuseppe, Biviano, Ivano, Bocchini, Renato, Bonventre, Sebastiano, Bossa, Fabrizio, Brandimarte, Giovanni, Cannizzaro, Renato, Cicala, Michele, Cipolletta, Livio, Clara, Virgilio, Cogliandro, Rosanna, Comandini, Giulia, Corazziari, Enrico, Crotta, Sergio, Cuomo, Rosario, D'Alba, Lucia, De Giorgi, Francesco, Del Piano, Mario, Di Fonzo, Michela, Di Mario, Francesco, Di Stefano, Michele, D'Onofrio, Vittorio, Efthymakis, Kostantino, Fiore, Pierluigi, Fortuna, Manuela, Fries, Walter, Gaetani, Eleonora, Galeazzi, Francesca, Gasbarrini, Antonio, Geccherle, Andrea, Giangregorio, Francesco, Girardi, Lisa, Grassini, Mario, Groppo, Marzia, Guarnieri, Giovanni, Lo Cascio, Massimiliano, Lolli, Roberto, Luzza, Francesco, Macarri, Giampiero, Marino, Maria, Miraglia, Stefania, Monastra, Santo, Neri, Maria Cristina, Neri, Matteo, Noris, Roberto Antonio, Orselli, Silvia, Passaretti, Sandro, Paviotti, Alberto, Pazzi, Paolo, Pilotto, Alberto, Portincasa, Piero, Ranaldo, Nunzio, Ravelli, Paolo, Rogai, Francesca, Sablich, Renato, Savarino, Vincenzo, Spinzi, Giancarlo, Stanghellini, Vincenzo, Tammaro, Leonardo, Torresan, Francesco, Usai Satta, Paolo, Valle, C. Claudio, Altomare, D., Annese, V., Badiali, D., Basilisco, G., Bassotti, G., Battaglia, E., Bazzocchi, G., Bellini, M., Bendia, E., Benini, L., Biscaglia, G., Biviano, I., Bocchini, R., Bonventre, S., Bossa, F., Brandimarte, G., Cannizzaro, R., Cicala, M., Cipolletta, L., Clara, V., Cogliandro, R., Comandini, G., Corazziari, E., Crotta, S., Cuomo, R., D'Alba, L., De Giorgi, F., Del Piano, M., Di Fonzo, M., Di Mario, F., Di Stefano, M., D'Onofrio, V., Efthymakis, K., Fiore, P., Fortuna, M., Fries, W., Gaetani, E., Galeazzi, F., Gasbarrini, A., Geccherle, A., Giangregorio, F., Girardi, L., Grassini, M., Groppo, M., Guarnieri, G., Lo Cascio, M., Lolli, R., Luzza, F., Macarri, G., Marino, M., Miraglia, S., Monastra, S., Neri, M., Noris, R., Orselli, S., Passaretti, S., Paviotti, A., Pazzi, P., Pilotto, A., Portincasa, P., Ranaldo, N., Ravelli, P., Rogai, F., Sablich, R., Savarino, V., Spinzi, G., Stanghellini, V., Tammaro, L., Torresan, F., Usai Satta, P., and Valle, C.
- Subjects
Adult ,Male ,Quality of life ,medicine.medical_specialty ,Constipation ,Cross-sectional study ,Physiology ,Bloating ,Chronic constipation ,Functional constipation ,Irritable bowel syndrome ,Patient-reported outcomes ,Treatment satisfaction ,Endocrine and Autonomic Systems ,Gastroenterology ,Cross-Sectional Studies ,Female ,Flatulence ,Humans ,Irritable Bowel Syndrome ,Middle Aged ,Prevalence ,Quality of Life ,Surveys and Questionnaires ,Endocrine and Autonomic System ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Patient-reported outcome ,Settore MED/12 - Gastroenterologia ,business.industry ,Settore MED/09 - MEDICINA INTERNA ,medicine.disease ,Settore MED/18 - Chirurgia Generale ,Tolerability ,030220 oncology & carcinogenesis ,Physical therapy ,030211 gastroenterology & hepatology ,medicine.symptom ,business - Abstract
Background The management of bloating is unclear and its relationship with patients' well-being and treatment satisfaction independent of other abdominal symptoms is uncharacterized. We evaluated the association of bloating with patient-reported outcomes. Methods Thirty-nine centers for functional gastrointestinal disorders joined the laxative inadequate relief survey. We enrolled 2203 consecutive outpatients with functional constipation (FC) or constipation-predominant irritable bowel syndrome (IBS-C) in two cross-sectional waves. Both wave 1 and 2 included the SF-12, the patient assessment of constipation-symptoms (PAC-SYM), and the treatment satisfaction questionnaire for medication (TSQM-2). Wave 2 only included a global rating of change (GRC) scale to assess patients' assessment of efficacy concerning treatment switches occurred in the 3 months prior to the interview. Bloating in the abdomen was defined on the basis of PAC-SYM item 3. Key Results The average age was 50.1 years (SD, 16.7) and 82.1% of patients were women. The prevalence of bloating was 91.6% (n = 1970). Bloating was associated with SF-12 Physical Composite Score (p < 0.01), SF-12 Mental Composite Score (p < 0.01), GRC (p < 0.01), Satisfaction with treatment effectiveness (p < 0.01), convenience of administration (p < 0.01), and side effects (p < 0.01) after adjustment for possible confounders. Conclusions & Inferences Our data suggest that patients regard bloating as a key element in assessing clinical changes and treatments' efficacy as this symptom exerts a strong influence on patient-reported outcomes independent of possible confounders and other symptoms of constipation. Our data provide the rationale to investigate the efficacy and tolerability of new treatments specifically addressing this important, yet disregarded, patients' complain.
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- 2016
27. The PROSIT-BIO Cohort: A Prospective Observational Study of Patients with Inflammatory Bowel Disease Treated with Infliximab Biosimilar
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Fiorino, Gionata, Manetti, Natalia, Armuzzi, Alessandro, Orlando, Ambrogio, Variola, Angela, Bonovas, Stefanos, Bossa, Fabrizio, Maconi, Giovanni, D'Incà, Renata, Lionetti, Paolo, Cantoro, Laura, Fries, Walter, Annunziata, Maria L., Costa, Francesco, Terpin, Maria M., Biancone, Livia, Cortelezzi, Claudio C., Amato, Arnaldo, Ardizzone, Sandro, Danese, Silvio, Guidi, Luisa, Rizzuto, Giulia, Massella, Arianna, Andriulli, Angelo, Massari, Alessandro, Lorenzon, Greta, Ghione, Silvia, Kohn, Anna, Ventra, Agostino, Annese, Vito, Principi, Mariabeatrice, Di Girolamo, Maria, Bertani, Angela, Saettone, Silvia, Tari, Roberto, Petruzzellis, Carlo, Guglielmi, Francesco W., Mazzuoli, Silvia, Cappello, Maria, Viola, Anna, Castiglione, Fabiana, Nardone, Olga, Di Sabatino, Antonio, Saibeni, Simone, Bezzio, Cristina, Caserta, Luigi, Parodi, Maria Caterina, Meucci, Gianmichele, Colli, Agostino, Ronchetti, Anna, Vecchi, Maurizio, Bertani, Lorenzo, Bosani, Matteo A., Tronconi, Edoardo, Imperiali, Gianni, Salerno, Raffaele, Rogai, Francesca, Milani, Stefano, Pugliese, Daniela, Renna, Sara, Geccherle, Andrea, Martino, Giuseppina, Cassinotti, Andrea, Fiorino, G, Manetti, N, Armuzzi, A, Orlando, A, Variola, A, Bonovas, S, Bossa, F, Maconi, G, D'Inca, R, Lionetti, P, Cantoro, L, Fries, W, Annunziata, Ml, Costa, F, Terpin, Mm, Biancone, L, Cortelezzi, Cc, Amato, A, Ardizzone, S, Danese, S, Guidi, L, Rizzuto, G, Massella, A, Andriulli, A, Massari, A, Lorenzon, G, Ghione, S, Kohn, A, Ventra, A, and Annese, V
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Male ,Databases, Factual ,Ulcerative ,Rate ratio ,Inflammatory bowel disease ,0302 clinical medicine ,Crohn Disease ,Monoclonal ,Immunology and Allergy ,Prospective Studies ,Remsima ,Prospective cohort study ,Infusions, Intravenous ,biosimilar ,Crohn's disease ,CT-P13 ,inflammatory bowel disease ,Inflectra ,Infliximab ,ulcerative colitis ,Gastroenterology ,Adolescent ,Adult ,Antibodies, Monoclonal ,Biosimilar Pharmaceuticals ,Colitis, Ulcerative ,Female ,Gastrointestinal Agents ,Humans ,Treatment Outcome ,Young Adult ,Colitis ,Ulcerative colitis ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Intravenous ,Cohort study ,medicine.drug ,medicine.medical_specialty ,Infusions ,Crohn's disease, ulcerative colitis, inflammatory bowel disease, Infliximab, Remsima, Inflectra, biosimilar, CT-P13 ,Antibodies ,03 medical and health sciences ,Databases ,Internal medicine ,medicine ,Adverse effect ,Factual ,business.industry ,Settore MED/09 - MEDICINA INTERNA ,medicine.disease ,business - Abstract
Background: Few data are available on the safety and efficacy of infliximab biosimilar CT-P13 in patients with ulcerative colitis and Crohn's disease. Methods: A prospective, multicenter, cohort study using a structured database. Results: Consecutive patients (313 Crohn's disease and 234 ulcerative colitis) were enrolled from 31 referral centers 311 patients were naive to anti-tumor necrosis factor alpha, 139 had a previous exposure to biologics, and the remaining 97 were switched to CT-P13 after a mean of 18 6 14 infusions of infliximab. The mean follow-up was 4.3 6 +/- 2.8 months, and the total follow-up time was 195 patient-years. After 2061 infusions, 66 serious adverse events were reported (12.1%), 38 (6.9%) of them were infusion-related reactions. The biosimilar had to be stopped in 29 (5.3%) cases for severe infusion reactions (8 naive, 19 previous exposed, and 2 switch), and in further 16 patients (2.9%) for other serious adverse events. Infusion reactions were significantly more frequent in patients pre-exposed to infliximab than to other anti-tumor necrosis factor alpha (incidence rate ratio = 2.82, 95% CI: 1.05-7.9). The efficacy of the biosimilar was evaluated in 434 patients who received treatment for at least 8 weeks, using time-to-event methods for censored observations: 35 patients were primary failures (8.1%). After further 8, 16, and 24 weeks, the efficacy estimations were 95.7%, 86.4%, and 73.7% for naive, 97.2%, 85.2%, and 62.2% for pre-exposed, and 94.5%, 90.8%, and 78.9% for switch, respectively (log-rank P = 0.64). Conclusions: Although no direct comparison was performed, preliminary data on efficacy and safety of CT-P13 were in line with those of infliximab.
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- 2017
28. Economic implications in inflammatory bowel disease: results from a retrospective analysis in an Italian Centre
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Variola, Angela, primary, Massella, Arianna, additional, Geccherle, Andrea, additional, Bocus, Paolo, additional, Tessari, Roberto, additional, Zuppini, Teresa, additional, and Ravasio, Roberto, additional
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- 2017
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29. A Prolonged Follow-Up on the Efficacy and Safety of Infliximab Biosimilar CT-P13 in IBD Across Italy: The Prosit Cohort
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Armuzzi, Alessandro, primary, Fiorino, Gionata, additional, Variola, Angela, additional, Manetti, Natalia, additional, Fries, Walter, additional, Rizzuto, Giulia, additional, Bossa, Fabrizio, additional, Cappello, Maria, additional, Biancone, Livia, additional, D'Inca, Renata, additional, Cantoro, Laura, additional, Castiglione, Fabiana, additional, Principi, Mariabeatrice, additional, Annunziata, Maria Laura, additional, Di Girolamo, Maria, additional, Terpin, Maria M., additional, Cortelezzi, Claudio C., additional, Costa, Francesco, additional, Amato, Arnaldo, additional, Di Sabatino, Antonio, additional, Saibeni, Simone, additional, Meucci, Giammichele, additional, Petruzzellis, Carlo, additional, Tari, Roberto, additional, Guglielmi, Francesco W., additional, Guidi, Luisa, additional, Danese, Silvio, additional, Rogai, Francesca, additional, Geccherle, Andrea, additional, Ventra, Agostino, additional, Orlando, Ambrogio, additional, Andriulli, Angelo, additional, Scrivo, Barbara, additional, Troncone, Edoardo, additional, Caccaro, Roberta, additional, Kohn, Anna, additional, Nardone, Olga Maria, additional, Pugliese, Daniela, additional, and Annese, Vito, additional
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- 2017
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30. Fiberoptic bronchoscopy for the detection of the gastric pepsin (Pep-test)
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Pomari, Carlo, primary, Mauroner, Luisa, additional, Paiano, Simona, additional, Assante, Luca Rosario, additional, Bertolaccini, Luca, additional, Ruffo, Giacomo, additional, Mainardi, Paride, additional, Bocus, Paolo, additional, Geccherle, Andrea, additional, Albanese, Sergio Ivan, additional, and Ciaffoni, Stefano, additional
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- 2016
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31. Bronchial reacutization and gastroesophageal reflux: is there a potential clinical correlation?
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Pomari, Carlo, primary, Mauroner, Luisa, additional, Paiano, Simona, additional, Assante, Luca Rosario, additional, Bertolaccini, Luca, additional, Ruffo, Giacomo, additional, Mainardi, Paride, additional, Bocus, Paolo, additional, Geccherle, Andrea, additional, Albanese, Sergio Ivan, additional, and Ciaffoni, Stefano, additional
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- 2016
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32. 453 - A Prolonged Follow-Up on the Efficacy and Safety of Infliximab Biosimilar CT-P13 in IBD Across Italy: The Prosit Cohort
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Armuzzi, Alessandro, Fiorino, Gionata, Variola, Angela, Manetti, Natalia, Fries, Walter, Rizzuto, Giulia, Bossa, Fabrizio, Cappello, Maria, Biancone, Livia, D'Inca, Renata, Cantoro, Laura, Castiglione, Fabiana, Principi, Mariabeatrice, Annunziata, Maria Laura, Di Girolamo, Maria, Terpin, Maria M., Cortelezzi, Claudio C., Costa, Francesco, Amato, Arnaldo, Di Sabatino, Antonio, Saibeni, Simone, Meucci, Giammichele, Petruzzellis, Carlo, Tari, Roberto, Guglielmi, Francesco W., Guidi, Luisa, Danese, Silvio, Rogai, Francesca, Geccherle, Andrea, Ventra, Agostino, Orlando, Ambrogio, Andriulli, Angelo, Scrivo, Barbara, Troncone, Edoardo, Caccaro, Roberta, Kohn, Anna, Nardone, Olga Maria, Pugliese, Daniela, and Annese, Vito
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- 2017
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33. Anastomosis configuration and technique following ileocaecal resection for Crohn’s disease: a multicentre study
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Celentano, V, Pellino, G, Spinelli, A, Selvaggi, F, SICCR Current status of Crohn’s disease surgery collaborative, Rottoli, M, Poggioli, G, Sica, G, Giglio, Mc, Campanelli, M, Coco, C, Rizzo, G, Sionne, F, Colombo, F, Sampietro, G, Lamperti, G, Foschi, D, Ficari, F, Vacca, L, Cricchio, M, Giudici, F, Selvaggi, L, Sciaudone, G, Peltrini, R, Manfreda, A, Bucci, L, Galleano, R, Ghazouani, O, Zorcolo, L, Deidda, S, Restivo, A, Braini, A, Di Candido, F, Sacchi, M, Carvello, M, Martorana, S, Bordignon, G, Angriman, I, Variola, A, Di Ruscio, M, Barugola, G, Geccherle, A, Tropeano, Fp, Luglio, G, Tanzanu, M, Sasia, D, Migliore, M, Giuffrida, Mc, Marrano, E, Moretto, G, Impellizzeri, H, Gallo, G, Vescio, G, Sammarco, G, Terrosu, G, Calini, G, Bondurri, A, Maffioli, A, Zaffaroni, G, Resegotti, A, Mistrangelo, M, Allaix, Me, Botti, F, Prati, M, Boni, L, Perotti, S, Mineccia, M, Giuliani, A, Romano, L, Graziano, Gmp, Pugliese, L, Pietrabissa, A, Delaini, G, on behalf of the Italian Society of Colorectal Surgery SICCR., Celentano, Valerio, Pellino, Gianluca, Spinelli, Antonino, Selvaggi, Francesco, Rottoli, Matteo, Poggioli, Gilberto, Sica, Giuseppe, Giglio, Mariano Cesare, Campanelli, Michela, Coco, Claudio, Rizzo, Gianluca, Sionne, Francesco, Colombo, Francesco, Sampietro, Gianluca, Lamperti, Giulia, Foschi, Diego, Ficari, Ferdinando, Vacca, Ludovica, Cricchio, Marta, Giudici, Francesco, Selvaggi, Lucio, Sciaudone, Guido, Peltrini, Roberto, Manfreda, Andrea, Bucci, Luigi, Galleano, Raffaele, Ghazouani, Omar, Zorcolo, Luigi, Deidda, Simona, Restivo, Angelo, Braini, Andrea, Di Candido, Francesca, Sacchi, Matteo, Carvello, Michele, Martorana, Stefania, Bordignon, Giovanni, Angriman, Imerio, Variola, Angela, Di Ruscio, Mirko, Barugola, Giuliano, Geccherle, Andrea, Tropeano, Francesca Paola, Luglio, Gaetano, Tanzanu, Marta, Sasia, Diego, Migliore, Marco, Giuffrida, Maria Carmela, Marrano, Enrico, Moretto, Gianluigi, Impellizzeri, Harmony, Gallo, Gaetano, Vescio, Giuseppina, Sammarco, Giuseppe, Terrosu, Giovanni, Calini, Giacomo, Bondurri, Andrea, Maffioli, Anna, Zaffaroni, Gloria, Resegotti, Andrea, Mistrangelo, Massimiliano, Allaix, Marco Ettore, Botti, Fiorenzo, Prati, Matteo, Boni, Luigi, Perotti, Serena, Mineccia, Michela, Giuliani, Antonio, Romano, Lucia, Graziano, Giorgio Maria Paolo, Pugliese, Luigi, Pietrabissa, Andrea, Delaini, GianGaetano, Celentano, V., Pellino, G., Spinelli, A., Selvaggi, F., Rottoli, M., Poggioli, G., Sica, G., Giglio, M. C., Campanelli, M., Coco, C., Rizzo, G., Sionne, F., Colombo, F., Sampietro, G., Lamperti, G., Foschi, D., Ficari, F., Vacca, L., Cricchio, M., Giudici, F., Selvaggi, L., Sciaudone, G., Peltrini, R., Manfreda, A., Bucci, L., Galleano, R., Ghazouani, O., Zorcolo, L., Deidda, S., Restivo, A., Braini, A., Di Candido, F., Sacchi, M., Carvello, M., Martorana, S., Bordignon, G., Angriman, I., Variola, A., Di Ruscio, M., Barugola, G., Geccherle, A., Tropeano, F. P., Luglio, G., Tanzanu, M., Sasia, D., Migliore, M., Giuffrida, M. C., Marrano, E., Moretto, G., Impellizzeri, H., Gallo, G., Vescio, G., Sammarco, G., Terrosu, G., Calini, G., Bondurri, A., Maffioli, A., Zaffaroni, G., Resegotti, A., Mistrangelo, M., Allaix, M. E., Botti, F., Prati, M., Boni, L., Perotti, S., Mineccia, M., Giuliani, A., Romano, L., Graziano, G. M. P., Pugliese, L., Pietrabissa, A., Delaini, G. G., Delaini, Giangaetano, Jinodg, G., Candido, F. D., and Ruscio, M. D.
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Ileocaecal resection ,Male ,Crohn’s disease ,Leak ,Settore MED/18 - CHIRURGIA GENERALE ,Anastomotic Leak ,Inflammatory bowel disease ,Postoperative Complications ,0302 clinical medicine ,Crohn Disease ,Retrospective Studie ,Surgical ,80 and over ,Clinical endpoint ,Colorectal surgery ,National audit ,Adolescent ,Adult ,Aged ,Aged, 80 and over ,Anastomosis, Surgical ,Cecum ,Digestive System Surgical Procedures ,Elective Surgical Procedures ,Female ,Humans ,Ileum ,Laparoscopy ,Length of Stay ,Middle Aged ,Reconstructive Surgical Procedures ,Retrospective Studies ,Treatment Outcome ,Young Adult ,Crohn's disease ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Human ,medicine.medical_specialty ,Anastomosis ,03 medical and health sciences ,medicine ,Performed Procedure ,Reconstructive Surgical Procedure ,colorectal surgery ,national audit ,Elective Surgical Procedure ,business.industry ,Digestive System Surgical Procedure ,Plastic Surgery Procedures ,medicine.disease ,Settore MED/18 ,Surgery ,Crohn’s disease · Inflammatory bowel disease · Ileocaecal resection · Colorectal surgery · National audit ,Postoperative Complication ,business - Abstract
A limited ileocaecal resection is the most frequently performed procedure for ileocaecal CD and different anastomotic configurations and techniques have been described. This manuscript audited the different anastomotic techniques used in a national study and evaluated their influence on postoperative outcomes following ileocaecal resection for primary CD. This is a retrospective, multicentre, observational study promoted by the Italian Society of Colorectal Surgery (SICCR), including all adults undergoing elective ileocaecal resection for primary CD from June 2018 May 2019. Postoperative morbidity within 30days of surgery was the primary endpoint. Postoperative length of hospital stay (LOS) and anastomotic leak rate were the secondary outcomes. 427 patients were included. The side to side anastomosis was the chosen configuration in 380 patients (89%). The stapled anastomotic (n = 286; 67%), techniques were preferred to hand-sewn (n = 141; 33%). Postoperative morbidity was 20.3% and anastomotic leak 3.7%. Anastomotic leak was independent of the type of anastomosis performed, while was associated with an ASA grade ≥ 3, presence of perianal disease and ileocolonic localization of disease. Four predictors of LOS were identified after multivariate analysis. The laparoscopic approach was the only associated with a reduced LOS (p = 0.017), while age, ASA grade ≥ 3 or administration of preoperative TPN were associated with increased LOS. The side to side was the most commonly used anastomotic configuration for ileocolic reconstruction following primary CD resection. There was no difference in postoperative morbidity according to anastomotic technique and configuration. Anastomotic leak was associated with ASA grade ≥ 3, a penetrating phenotype of disease and ileo-colonic distribution of CD. A limited ileocaecal resection is the most frequently performed procedure for ileocaecal CD and different anastomotic configurations and techniques have been described. This manuscript audited the different anastomotic techniques used in a national study and evaluated their influence on postoperative outcomes following ileocaecal resection for primary CD. This is a retrospective, multicentre, observational study promoted by the Italian Society of Colorectal Surgery (SICCR), including all adults undergoing elective ileocaecal resection for primary CD from June 2018 May 2019. Postoperative morbidity within 30days of surgery was the primary endpoint. Postoperative length of hospital stay (LOS) and anastomotic leak rate were the secondary outcomes. 427 patients were included. The side to side anastomosis was the chosen configuration in 380 patients (89%). The stapled anastomotic (n = 286; 67%), techniques were preferred to hand-sewn (n = 141; 33%). Postoperative morbidity was 20.3% and anastomotic leak 3.7%. Anastomotic leak was independent of the type of anastomosis performed, while was associated with an ASA grade ≥ 3, presence of perianal disease and ileocolonic localization of disease. Four predictors of LOS were identified after multivariate analysis. The laparoscopic approach was the only associated with a reduced LOS (p = 0.017), while age, ASA grade ≥ 3 or administration of preoperative TPN were associated with increased LOS. The side to side was the most commonly used anastomotic configuration for ileocolic reconstruction following primary CD resection. There was no difference in postoperative morbidity according to anastomotic technique and configuration. Anastomotic leak was associated with ASA grade ≥ 3, a penetrating phenotype of disease and ileo-colonic distribution of CD.
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- 2021
34. Correction to: Surgical treatment of colonic Crohn's disease: a national snapshot study
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Gianluca M. Sampietro, Serena Perotti, A Geccherle, Andrea Braini, Mariano Cesare Giglio, Anna Maffioli, Antonino Spinelli, Valerio Celentano, Diego Sasia, Andrea Resegotti, Omar Ghazouani, Enrico Marrano, Angela Variola, Lucio Selvaggi, Marta Cricchio, G. Delaini, Marta Tanzanu, G Vescio, F. Sionne, Luigi Boni, Fiorenzo Botti, G. Rizzo, Andrea Pietrabissa, Claudio Coco, Gloria Zaffaroni, Roberto Peltrini, Ferdinando Ficari, Marco E. Allaix, Harmony Impellizzeri, Lucia Romano, A. Bondurri, Gaetano Gallo, Matteo Rottoli, Gaetano Luglio, Giacomo Calini, Giuseppe S. Sica, Giovanni Terrosu, M. Prati, Andrea Manfreda, Gilberto Poggioli, Luigi Pugliese, Giulia Lamperti, Ludovica Vacca, Michele Carvello, Francesca Paola Tropeano, Luigi Bucci, Francesco Colombo, Michela Mineccia, Diego Foschi, Matteo Sacchi, Imerio Angriman, Giovanni Bordignon, Luigi Zorcolo, Francesco Selvaggi, Angelo Restivo, Raffaele Galleano, Stefania Martorana, Gianluigi Moretto, Giorgio Maria Paolo Graziano, Marco Migliore, Maria Carmela Giuffrida, Giuseppe Sammarco, Massimiliano Mistrangelo, Guido Sciaudone, Gianluca Pellino, S. Deidda, Francesca Di Candido, Antonio Giuliani, Mirko Di Ruscio, Michela Campanelli, Giuliano Barugola, Francesco Giudici, Celentano, Valerio, Pellino, Gianluca, Rottoli, Matteo, Poggioli, Gilberto, Sica, Giuseppe, Giglio, Mariano Cesare, Campanelli, Michela, Coco, Claudio, Rizzo, Gianluca, Sionne, Francesco, Colombo, Francesco, Sampietro, Gianluca, Lamperti, Giulia, Foschi, Diego, Ficari, Ferdinando, Vacca, Ludovica, Cricchio, Marta, Giudici, Francesco, Selvaggi, Lucio, Sciaudone, Guido, Peltrini, Roberto, Manfreda, Andrea, Bucci, Luigi, Galleano, Raffaele, Ghazouani, Omar, Zorcolo, Luigi, Deidda, Simona, Restivo, Angelo, Braini, Andrea, Di Candido, Francesca, Sacchi, Matteo, Carvello, Michele, Martorana, Stefania, Bordignon, Giovanni, Angriman, Imerio, Variola, Angela, Barugola, Giuliano, Di Ruscio, Mirko, Tanzanu, Marta, Geccherle, Andrea, Tropeano, Francesca Paola, Luglio, Gaetano, Sasia, Diego, Migliore, Marco, Giuffrida, Maria Carmela, Marrano, Enrico, Moretto, Gianluigi, Impellizzeri, Harmony, Gallo, Gaetano, Vescio, Giuseppina, Sammarco, Giuseppe, Terrosu, Giovanni, Calini, Giacomo, Bondurri, Andrea, Maffioli, Anna, Zaffaroni, Gloria, Resegotti, Andrea, Mistrangelo, Massimiliano, Allaix, Marco Ettore, Botti, Fiorenzo, Prati, Matteo, Boni, Luigi, Perotti, Serena, Mineccia, Michela, Giuliani, Antonio, Romano, Lucia, Graziano, Giorgio Maria Paolo, Pugliese, Luigi, Pietrabissa, Andrea, Delaini, Giangaetano, Spinelli, Antonino, and Selvaggi, Francesco
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medicine.medical_specialty ,Colonic Crohn's disease ,business.industry ,Crohn’s disease . Crohn’s colitis . Inflammatory bowel disease . Segmental colectomy . Proctocolectomy . National audit ,General surgery ,Vascular surgery ,Cardiac surgery ,Snapshot (photography) ,Cardiothoracic surgery ,medicine ,Surgery ,business ,Surgical treatment ,Abdominal surgery - Published
- 2021
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