333 results on '"Gearhart, Patricia J."'
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2. Different Mutation Signatures in DNA Polymerase η- and MSH6-Deficient Mice Suggest Separate Roles in Antibody Diversification
3. Unmasking Arterial-resident Autoreactive B cells involved in Atherosclerosis and Peripheral Artery Disease Progression
4. Pre-activation of follicular B cells in old mice generates a hyper-response during germinal center reaction.
5. Sex and age differences in B cell frequencies and antibody responses following influenza vaccination in highly vaccinated adult populations
6. Establishing novel and unique technology to uncover how Activation-Induced Deaminase specifically targets immunoglobulin regions
7. B cell dysfunction during aging is not dependent on stem cell aging
8. Altered Spectra of Hypermutation in DNA Repair-Deficient Mice
9. Altered Spectra of Hypermutation in Antibodies from Mice Deficient for the DNA Mismatch Repair Protein PMS2
10. The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation
11. ATM deficiency promotes development of murine B-cell lymphomas that resemble diffuse large B-cell lymphoma in humans
12. Greater Breadth of Vaccine-Induced Immunity in Females than Males Is Mediated by Increased Antibody Diversity in Germinal Center B Cells
13. The IgHEμ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation
14. Promoter Proximity Defines Mutation Window for VH and VΚ Genes Rearranged to Different J Genes
15. Sex differences in B cell frequencies and antibody responses following influenza vaccination in healthcare workers during the 2019–2020 season
16. Follicular B cells from old mice are hyper-responsive and produce non-specific antibodies.
17. Arterial antibodies promote atherosclerotic plaque development in mice
18. Hijacked DNA Repair Proteins and Unchained DNA Polymerases
19. Preface
20. Production of Antibodies of Identical Idiotype but Diverse Immunoglobulin Classes by Cells Derived from a Single Stimulated B Cell
21. Early Rearrangements of Genes Encoding Murine Immunoglobulin κ Chains, Unlike Genes Encoding Heavy Chains, Use Variable Gene Segments Dispersed throughout the Locus
22. Mutation in a Reporter Gene Depends on Proximity to and Transcription of Immunoglobulin Variable Transgenes
23. Adult B-Cell Repertoire is Biased toward Two Heavy-Chain Variable-Region Genes that Rearrange Frequently in Fetal Pre-B Cells
24. Successive Switching of Antibody Isotypes Expressed within the Lines of a B-Cell Clone
25. Clusters of Point Mutations are Found Exclusively around Rearranged Antibody Variable Genes
26. Auto-Antibody Production During Experimental Atherosclerosis in ApoE-/- Mice
27. Small Molecule Inhibitors of Activation-Induced Deaminase Decrease Class Switch Recombination in B Cells
28. Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashion
29. Controlling somatic hypermutation in immunoglobulin variable and switch regions
30. Transcriptome and IgH Repertoire Analyses Show That CD11chi B Cells Are a Distinct Population With Similarity to B Cells Arising in Autoimmunity and Infection
31. Nucleotide excision repair in an immunoglobulin variable gene is less efficient than in a housekeeping gene
32. Different mutation signatures in DNA polymerase [eta]- and MSH6-deficient mice suggest separate roles in antibody diversification
33. Switch Regions, Chromatin Accessibility and AID Targeting
34. Impact of Age on Hypermutation of Immunoglobulin Variable Genes in Humans
35. AID and Somatic Hypermutation
36. Somatic hypermutation: subverted DNA repair
37. Esophagogastric adenocarcinoma in an E1A/E1B transgenic model involves p53 disruption
38. Different B Cell Populations Mediate Early and Late Memory During an Endogenous Immune Response
39. From Influenza Virus Infections to Lupus: Synchronous Estrogen Receptorαand RNA Polymerase II Binding Within the Immunoglobulin Heavy Chain Locus
40. Sex differences in immune responses to influenza vaccine in healthcare workers during the 2019–2020 influenza season
41. What Targets Somatic Hypermutation to the Immunoglobulin Loci?
42. Commentary for the Special Issue on ‘Aging and Sex in Immunity’
43. Matters of life and death: How estrogen and estrogen receptor binding to the immunoglobulin heavy chain locus may influence outcomes of infection, allergy, and autoimmune disease
44. B cells from young and old mice switch isotypes with equal frequencies after ex vivo stimulation
45. Preface
46. B cells pay a price
47. Immunology: The roots of antibody diversity
48. Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes
49. Auto-Antibody Production During Experimental Atherosclerosis in ApoE-/- Mice.
50. 45 CD11c-hi T-bet+ B cells contribute to the pathogenesis of SLE through generation of autoreactive plasma cells
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