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166 results on '"Gazzini, Luca"'

14. Prognostic Significance of Tumor–Stroma Ratio (TSR) in Head and Neck Squamous Cell Carcinoma: Systematic Review and Meta-Analysis.

Author

Girolami, Ilaria, Damiani, Domenico, Negro, Rosa, Abousiam, Monir, Gazzini, Luca, Calabrese, Luca, and Hanspeter, Esther

Subjects
OVERALL survival, SURVIVAL rate, PROGNOSIS, SQUAMOUS cell carcinoma, ORAL cancer
Abstract

The management of head and neck squamous cell carcinoma (HNSCC) relies heavily on TNM staging and WHO histologic grading; however, in recent years, the analysis of prognostic markers expressed in the tumor stroma has gained attention. The tumor–stroma ratio (TSR) quantifies the proportion of tumor tissue relative to the surrounding stromal tissue; it is assessed with the percentage of stromal tissue within the tumor area, with a cutoff point of 50% being widely used to discriminate high-stroma cancer. In this systematic review and meta-analysis, we investigated the potential prognostic role of the TSR in HNSCC. After a literature screening, 24 studies dealing with the TSR and survival outcomes were included. The TSR showed a significant association with overall survival (OS) in both unadjusted and adjusted measures (RR 2.04, CI 1.57–2.65, p < 0.01; HR 2.36 CI 1.89–2.94, p < 0.00001), with an even stronger prognostic potential in oral cavity/oral tongue cancers (RR 2.44 CI 1.84–3.22, p < 0.00001). The TSR also showed prognostic value when dealing with cancer-specific survival and was associated with a reduction in disease-free survival (DFS). In particular, the TSR also retained its prognostic role in terms of DFS when specifically considering early-stage cancers in both unadjusted and adjusted analyses (RR 1.81 CI 1.57–2.10, p < 0.00001; HR 2.09 CI 1.58–2.76, p < 0.00001). Therefore, we conclude that the TSR is a reliable prognostic marker that is easy to assess in routine histological slides and can be effectively implemented in the routine evaluation of HNSCC. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Endovascular coils extrusion after internal carotid artery occlusion: From management to follow‐up

Author

Vinciguerra, Alessandro, primary, Turri‐Zanoni, Mario, additional, Ferrari, Marco, additional, Mattavelli, Davide, additional, Giorgianni, Andrea, additional, Fazio, Enrico, additional, Pierro, Francesco Di, additional, Rampinelli, Vittorio, additional, Gazzini, Luca, additional, Verillaud, Benjamin, additional, Schreiber, Alberto, additional, Calabrese, Luca, additional, Bignami, Maurizio, additional, Battaglia, Paolo, additional, Nicolai, Piero, additional, Castelnuovo, Paolo, additional, and Herman, Philippe, additional

Published
2024
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25. Oral Reconstruction with Locoregional Flaps after Cancer Ablation: A Systematic Review of the Literature.

Author

Accorona, Remo, Di Furia, Domenico, Cremasco, Alice, Gazzini, Luca, Mevio, Niccolò, Pilolli, Francesco, Achena, Andrea, Iftikhar, Haissan, Awny, Shadi, Ormellese, Giorgio Luigi, Dragonetti, Alberto Giulio, and De Virgilio, Armando

Subjects
LITERATURE reviews, ALVEOLAR process, HARD palate, ORAL cancer, ELECTRONIC information resource searching
Abstract

Introduction: The planning of oral reconstruction after tumor resection is a pivotal point for head and neck surgeons. It is mandatory to consider two aspects: the size of the surgical defect and the complexity of the oral cavity as an anatomical region. We offer a review of the literature that focuses on four types of locoregional flaps that can be profitably used for such reconstruction: infrahyoid (IF), nasolabial (NF), platysma (PF), and submental (SF). Methods: The study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. This systematic review was carried out according to the PICOS acronym through a comprehensive electronic search on PubMed/MEDLINE, Cochrane Library, and Google Scholar databases. For each selected article, we extrapolated eight main parameters, of which all mean values were compared through an ANOVA test. The dimensions of the oral defects were referred to as "small" (<7 cm2), "medium" (7–50 cm2), or "large" (>50 cm2). Results: A total of 139 articles were selected with a total of 5898 patients. The mean ages for each type of flap were not statistically significant (p = 0.30, p > 0.05). Seven sublocations of oral defects were reported: The most common was the tongue (2003 [34.0%] patients), followed by the floor of the mouth (1786 [30.4%]), buccal mucosa (981 [16.6%]), cheek (422 [7.2%]), hard palate (302 [5.1%]), alveolar ridge (217 [3.7%]), and retromolar trigone (187 [3.2%]). The defects were mainly medium-sized (4507 [76.4%] patients), and fewer were small-sized (1056 [17.9%]) or large-sized (335 [5.7%]). Complications were noted, the most frequent of which was flap necrosis, seen in 0.57% of cases. The functional and esthetical results were mainly positive. Conclusions: Locoregional flaps represent a good alternative in medium-sized defects as well as a fairly good alternative in small- and large-sized defects when other options are ruled out. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Compartmental tongue surgery for intermediate‐advanced squamous cell carcinoma: A multicentric study

Author

Calabrese, Luca, primary, Tagliabue, Marta, additional, Grammatica, Alberto, additional, De Berardinis, Rita, additional, Corso, Federica, additional, Gazzini, Luca, additional, Abousiam, Monir, additional, Fazio, Enrico, additional, Mattavelli, Davide, additional, Fontanella, Walter, additional, Giannini, Lorenzo, additional, Bresciani, Lorenzo, additional, Bruschini, Roberto, additional, Gandini, Sara, additional, Piazza, Cesare, additional, and Ansarin, Mohssen, additional

Published
2023
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36. Impact of the COVID-19 pandemic on head and neck cancer diagnosis: data from a single referral center, South Tyrol, northern Italy

Author

Gazzini, Luca, primary, Fazio, Enrico, additional, Dallari, Virginia, additional, Accorona, Remo, additional, Abousiam, Monir, additional, Nebiaj, Aurel, additional, Giorgetti, Giovanni, additional, Girolami, Ilaria, additional, Vittadello, Fabio, additional, Magnato, Roberto, additional, Patscheider, Martin, additional, Mazzoleni, Guido, additional, and Calabrese, Luca, additional

Published
2021
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41. Step-by-Step Cadaver Dissection and Surgical Technique for Compartmental Tongue and Floor of Mouth Resection

Author

Grammatica, Alberto, primary, Piazza, Cesare, additional, Ferrari, Marco, additional, Verzeletti, Vincenzo, additional, Paderno, Alberto, additional, Mattavelli, Davide, additional, Schreiber, Alberto, additional, Lombardi, Davide, additional, Fazio, Enrico, additional, Gazzini, Luca, additional, Giorgetti, Giovanni, additional, Buffoli, Barbara, additional, Rodella, Luigi Fabrizio, additional, Nicolai, Piero, additional, and Calabrese, Luca, additional

Published
2021
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50. Leiomyosarcoma of the Larynx: A Complex Diagnosis.

Author

Molteni, Gabriele, Soloperto, Davide, Fabbris, Cristoforo, Gazzini, Luca, De Rossi, Stefano, Valotto, Giovanni, and Marchioni, Daniele

Subjects
CANCER chemotherapy, CANCER relapse, CARTILAGE, COMPUTED tomography, LARYNGOSCOPY, LARYNX, LARYNGEAL tumors, PALLIATIVE treatment, TRACHEAL cartilage, LEIOMYOSARCOMA
Abstract

The article presents a case report of an 84-year-old man with dysphonia and a polypoid lesion of the right true vocal fold with normal motility. Following 2 surgeries, he had thickening of the right laryngeal wall with wide fluid collection and underwent debridement of the necrotic tissue and purulent collection drainage, and a laryngectomy which showed transglottic extenstion of the ulcerated material consistent with leiomyosarcoma. The patient's condition improved, and oral feeding started.

Published
2020
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