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388 results on '"Gazzaniga, Paola"'

2. Serial Analysis of Circulating Tumor Cells in Metastatic Breast Cancer Receiving First-Line Chemotherapy

Author

Magbanua, Mark Jesus M, Hendrix, Laura H, Hyslop, Terry, Barry, William T, Winer, Eric P, Hudis, Clifford, Toppmeyer, Deborah, Carey, Lisa Anne, Partridge, Ann H, Pierga, Jean-Yves, Fehm, Tanja, Vidal-Martínez, José, Mavroudis, Dimitrios, Garcia-Saenz, Jose A, Stebbing, Justin, Gazzaniga, Paola, Manso, Luis, Zamarchi, Rita, Antelo, María Luisa, De Mattos-Arruda, Leticia, Generali, Daniele, Caldas, Carlos, Munzone, Elisabetta, Dirix, Luc, Delson, Amy L, Burstein, Harold J, Qadir, Misbah, Ma, Cynthia, Scott, Janet H, Bidard, François-Clément, Park, John W, and Rugo, Hope S

Subjects
Cancer, Prevention, Breast Cancer, Clinical Research, Breast Neoplasms, Female, Humans, Neoplastic Cells, Circulating, Prognosis, Progression-Free Survival, Proportional Hazards Models, Reproducibility of Results, Retrospective Studies, Treatment Outcome, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundWe examined the prognostic significance of circulating tumor cell (CTC) dynamics during treatment in metastatic breast cancer (MBC) patients receiving first-line chemotherapy.MethodsSerial CTC data from 469 patients (2202 samples) were used to build a novel latent mixture model to identify groups with similar CTC trajectory (tCTC) patterns during the course of treatment. Cox regression was used to estimate hazard ratios for progression-free survival (PFS) and overall survival (OS) in groups based on baseline CTCs, combined CTC status at baseline to the end of cycle 1, and tCTC. Akaike information criterion was used to select the model that best predicted PFS and OS.ResultsLatent mixture modeling revealed 4 distinct tCTC patterns: undetectable CTCs (56.9% ), low (23.7%), intermediate (14.5%), or high (4.9%). Patients with low, intermediate, and high tCTC patterns had statistically significant inferior PFS and OS compared with those with undetectable CTCs (P < .001). Akaike Information Criterion indicated that the tCTC model best predicted PFS and OS compared with baseline CTCs and combined CTC status at baseline to the end of cycle 1 models. Validation studies in an independent cohort of 1856 MBC patients confirmed these findings. Further validation using only a single pretreatment CTC measurement confirmed prognostic performance of the tCTC model.ConclusionsWe identified 4 novel prognostic groups in MBC based on similarities in tCTC patterns during chemotherapy. Prognostic groups included patients with very poor outcome (intermediate + high CTCs, 19.4%) who could benefit from more effective treatment. Our novel prognostic classification approach may be used for fine-tuning of CTC-based risk stratification strategies to guide future prospective clinical trials in MBC.

Published
2021

3. An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile

Author

De Angelis, Maria Laura, Francescangeli, Federica, Nicolazzo, Chiara, Signore, Michele, Giuliani, Alessandro, Colace, Lidia, Boe, Alessandra, Magri, Valentina, Baiocchi, Marta, Ciardi, Antonio, Scarola, Francesco, Spada, Massimo, La Torre, Filippo, Gazzaniga, Paola, Biffoni, Mauro, De Maria, Ruggero, and Zeuner, Ann

Published
2022
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4. Blood Extracellular Vesicles Beyond Circulating Tumour Cells: A Valuable Risk Stratification Biomarker in High-Risk Non-Muscle-Invasive Bladder Cancer Patients.

Author

Magri, Valentina, Marino, Luca, Del Giudice, Francesco, De Meo, Michela, Siringo, Marco, De Berardinis, Ettore, Gandini, Orietta, Santini, Daniele, Nicolazzo, Chiara, and Gazzaniga, Paola

Subjects
NON-muscle invasive bladder cancer, TRANSURETHRAL resection of bladder, EXTRACELLULAR vesicles, SURVIVAL rate, PROGNOSIS
Abstract

Non-muscle-invasive bladder cancer (NMIBC) prognosis varies significantly due to the biological and clinical heterogeneity. High-risk stage T1-G3, comprising 15–20% of NMIBCs, involves the lamina propria and is associated with higher rates of recurrence, progression, and cancer-specific mortality. In the present study, we have evaluated the enumeration of tumour-derived extracellular vesicles (tdEVs) and circulating tumour cells (CTCs) in high-risk NMIBC patients and their correlation with survival outcomes such as time to progression (TTP), and cancer-specific survival (CSS). Eighty-three high-risk T1-G3 NMIBC patients treated between September 2010 and January 2013 were included. Blood samples were collected before a transurethral resection of the bladder (TURB) and analysed using the CellSearch® system. The presence of at least one CTC was associated with a shorter TTP and CSS. Extending follow-up to 120 months and incorporating automated tdEV evaluation using ACCEPT software demonstrated that tdEV count may additionally stratify patient risk. Combining tdEVs and CTCs improves risk stratification for NMIBC progression, suggesting that tdEVs could be valuable biomarkers for prognosis and disease monitoring. Further research is needed to confirm these findings and establish the clinical significance of tdEVs in early-stage cancers. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Circulating Cancer-Associated Macrophage-like Cells as a Blood-Based Biomarker of Response to Immune Checkpoint Inhibitors

Author

Magri, Valentina, primary, De Renzi, Gianluigi, additional, Marino, Luca, additional, De Meo, Michela, additional, Siringo, Marco, additional, Gelibter, Alain, additional, Gareri, Roberta, additional, Cataldi, Chiara, additional, Giannini, Giuseppe, additional, Santini, Daniele, additional, Nicolazzo, Chiara, additional, and Gazzaniga, Paola, additional

Published
2024
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8. The clinical use of circulating tumor cells (CTCs) enumeration for staging of metastatic breast cancer (MBC): International expert consensus paper

Author

Cristofanilli, Massimo, Pierga, Jean-Yves, Reuben, James, Rademaker, Alfred, Davis, Andrew A., Peeters, Dieter J., Fehm, Tanja, Nolé, Franco, Gisbert-Criado, Rafael, Mavroudis, Dimitrios, Grisanti, Salvatore, Giuliano, Mario, Garcia-Saenz, Jose A., Stebbing, Justin, Caldas, Carlos, Gazzaniga, Paola, Manso, Luis, Zamarchi, Rita, de Lascoiti, Angela Fernandez, De Mattos-Arruda, Leticia, Ignatiadis, Michail, Cabel, Luc, van Laere, Steven J., Meier-Stiegen, Franziska, Sandri, Maria-Teresa, Vidal-Martinez, Jose, Politaki, Eleni, Consoli, Francesca, Generali, Daniele, Cappelletti, Maria Rosa, Diaz-Rubio, Eduardo, Krell, Jonathan, Dawson, Sarah-Jane, Raimondi, Cristina, Rutten, Annemie, Janni, Wolfgang, Munzone, Elisabetta, Carañana, Vicente, Agelaki, Sofia, Almici, Camillo, Dirix, Luc, Solomayer, Erich-Franz, Zorzino, Laura, Darrigues, Lauren, Reis-Filho, Jorge S., Gerratana, Lorenzo, Michiels, Stefan, Bidard, François-Clément, and Pantel, Klaus

Published
2019
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11. Genomic landscape and survival analysis of ctDNA “neo-RAS wild-type” patients with originally RAS mutant metastatic colorectal cancer

Author

Nicolazzo, Chiara, primary, Magri, Valentina, additional, Marino, Luca, additional, Belardinilli, Francesca, additional, Di Nicolantonio, Federica, additional, De Renzi, Gianluigi, additional, Caponnetto, Salvatore, additional, De Meo, Michela, additional, Giannini, Giuseppe, additional, Santini, Daniele, additional, Cortesi, Enrico, additional, and Gazzaniga, Paola, additional

Published
2023
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14. Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data

Author

Bidard, François-Clément, Peeters, Dieter J, Fehm, Tanja, Nolé, Franco, Gisbert-Criado, Rafael, Mavroudis, Dimitrios, Grisanti, Salvatore, Generali, Daniele, Garcia-Saenz, Jose A, Stebbing, Justin, Caldas, Carlos, Gazzaniga, Paola, Manso, Luis, Zamarchi, Rita, de Lascoiti, Angela Fernandez, De Mattos-Arruda, Leticia, Ignatiadis, Michail, Lebofsky, Ronald, van Laere, Steven J, Meier-Stiegen, Franziska, Sandri, Maria-Teresa, Vidal-Martinez, Jose, Politaki, Eleni, Consoli, Francesca, Bottini, Alberto, Diaz-Rubio, Eduardo, Krell, Jonathan, Dawson, Sarah-Jane, Raimondi, Cristina, Rutten, Annemie, Janni, Wolfgang, Munzone, Elisabetta, Carañana, Vicente, Agelaki, Sofia, Almici, Camillo, Dirix, Luc, Solomayer, Erich-Franz, Zorzino, Laura, Johannes, Helene, Reis-Filho, Jorge S, Pantel, Klaus, Pierga, Jean-Yves, and Michiels, Stefan

Published
2014
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15. An Orthotopic Patient-Derived Xenograft (PDX) Model Allows the Analysis of Metastasis-Associated Features in Colorectal Cancer

Author

De Angelis, Maria Laura, primary, Francescangeli, Federica, additional, Nicolazzo, Chiara, additional, Xhelili, Eljona, additional, La Torre, Filippo, additional, Colace, Lidia, additional, Bruselles, Alessandro, additional, Macchia, Daniele, additional, Vitale, Sara, additional, Gazzaniga, Paola, additional, Baiocchi, Marta, additional, and Zeuner, Ann, additional

Published
2022
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16. Modeling the Prognostic Impact of Circulating Tumor Cells Enumeration in Metastatic Breast Cancer for Clinical Trial Design Simulation

Author

Gerratana, Lorenzo, Pierga, Jean Yves Ves J.Y., Reuben, James, Davis, Andrew Adam, Wehbe, Firas F.H., Dirix, Luc Y, Fehm, Tanja Natascha T., Nolé, Franco, Gisbert-Criado, Rafael, Mavroudis, Dimitrios, Grisanti, Salvatore, García Sáenz, José Ángel J.A., Stebbing, Justin, Caldas, Carlos, Gazzaniga, Paola, Manso, Luis, Zamarchi, Rita, Bonotto, Marta, Fernandez de Lascoiti, Angela, de Mattos-Arruda, Letícia, Ignatiadis, Michail, Sandri, Maria Teresa, Generali, Daniele, De Angelis, Carmine, Dawson, Sarah Jane, Janni, Wolfgang, Carañana, Vicente, Riethdorf, Sabine, Solomayer, Erich-Franz, Puglisi, Fabio, Giuliano, Mario, Pantel, Klaus, Bidard, François-Clément, Cristofanilli, Massimo, Gerratana, Lorenzo, Pierga, Jean Yves Ves J.Y., Reuben, James, Davis, Andrew Adam, Wehbe, Firas F.H., Dirix, Luc Y, Fehm, Tanja Natascha T., Nolé, Franco, Gisbert-Criado, Rafael, Mavroudis, Dimitrios, Grisanti, Salvatore, García Sáenz, José Ángel J.A., Stebbing, Justin, Caldas, Carlos, Gazzaniga, Paola, Manso, Luis, Zamarchi, Rita, Bonotto, Marta, Fernandez de Lascoiti, Angela, de Mattos-Arruda, Letícia, Ignatiadis, Michail, Sandri, Maria Teresa, Generali, Daniele, De Angelis, Carmine, Dawson, Sarah Jane, Janni, Wolfgang, Carañana, Vicente, Riethdorf, Sabine, Solomayer, Erich-Franz, Puglisi, Fabio, Giuliano, Mario, Pantel, Klaus, Bidard, François-Clément, and Cristofanilli, Massimo

Abstract

Despite the strong prognostic stratification of circulating tumor cells (CTCs) enumeration in metastatic breast cancer (MBC), current clinical trials usually do not include a baseline CTCs in their design. This study aimed to generate a classifier for CTCs prognostic simulation in existing datasets for hypothesis generation in patients with MBC. A K-nearest neighbor machine learning algorithm was trained on a pooled dataset comprising 2436 individual MBC patients from the European Pooled Analysis Consortium and the MD Anderson Cancer Center to identify patients likely to have CTCs ≥ 5/7 mL blood (StageIVaggressive vs StageIVindolent). The model had a 65.1% accuracy and its prognostic impact resulted in a hazard ratio (HR) of 1.89 (Simulatedaggressive vs SimulatedindolentP < .001), similar to patients with actual CTCs enumeration (HR 2.76; P < .001). The classifier's performance was then tested on an independent retrospective database comprising 446 consecutive hormone receptor (HR)-positive HER2-negative MBC patients. The model further stratified clinical subgroups usually considered prognostically homogeneous such as patients with bone-only or liver metastases. Bone-only disease classified as Simulatedaggressive had a significantly worse overall survival (OS; P < .0001), while patients with liver metastases classified as Simulatedindolent had a significantly better prognosis (P < .0001). Consistent results were observed for patients who had undergone CTCs enumeration in the pooled population. The differential prognostic impact of endocrine- (ET) and chemotherapy (CT) was explored across the simulated subgroups. No significant differences were observed between ET and CT in the overall population, both in terms of progression-free survival (PFS) and OS. In contrast, a statistically significant difference, favoring CT over ET was observed among Simulatedaggressive patients (HR: 0.62; P = .030 and HR: 0.60; P = .037, respectively, for PFS and OS)., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

18. Modeling the Prognostic Impact of Circulating Tumor Cells Enumeration in Metastatic Breast Cancer for Clinical Trial Design Simulation

Author

Gerratana, Lorenzo, primary, Pierga, Jean-Yves, additional, Reuben, James M, additional, Davis, Andrew A, additional, Wehbe, Firas H, additional, Dirix, Luc, additional, Fehm, Tanja, additional, Nolé, Franco, additional, Gisbert-Criado, Rafael, additional, Mavroudis, Dimitrios, additional, Grisanti, Salvatore, additional, Garcia-Saenz, Jose A, additional, Stebbing, Justin, additional, Caldas, Carlos, additional, Gazzaniga, Paola, additional, Manso, Luis, additional, Zamarchi, Rita, additional, Bonotto, Marta, additional, Fernandez de Lascoiti, Angela, additional, De Mattos-Arruda, Leticia, additional, Ignatiadis, Michail, additional, Sandri, Maria-Teresa, additional, Generali, Daniele, additional, De Angelis, Carmine, additional, Dawson, Sarah-Jane, additional, Janni, Wolfgang, additional, Carañana, Vicente, additional, Riethdorf, Sabine, additional, Solomayer, Erich-Franz, additional, Puglisi, Fabio, additional, Giuliano, Mario, additional, Pantel, Klaus, additional, Bidard, François-Clément, additional, and Cristofanilli, Massimo, additional

Published
2022
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19. Additional file 1 of An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile

Author

De Angelis, Maria Laura, Francescangeli, Federica, Nicolazzo, Chiara, Signore, Michele, Giuliani, Alessandro, Colace, Lidia, Boe, Alessandra, Magri, Valentina, Baiocchi, Marta, Ciardi, Antonio, Scarola, Francesco, Spada, Massimo, La Torre, Filippo, Gazzaniga, Paola, Biffoni, Mauro, De Maria, Ruggero, and Zeuner, Ann

Abstract

Additional file 1:. Supplementary Methods.

Published
2022
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22. RAS Mutation Conversion in Bevacizumab-Treated Metastatic Colorectal Cancer Patients: A Liquid Biopsy Based Study

Author

Nicolazzo, Chiara, primary, Belardinilli, Francesca, additional, Vestri, Annarita, additional, Magri, Valentina, additional, De Renzi, Gianluigi, additional, De Meo, Michela, additional, Caponnetto, Salvatore, additional, Di Nicolantonio, Federica, additional, Cortesi, Enrico, additional, Giannini, Giuseppe, additional, and Gazzaniga, Paola, additional

Published
2022
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26. Comparison of Two Blood-Based Genotyping Tests to Investigate the KRAS G12C Mutation in Patients with Non-Small-Cell Lung Cancer at Failure of First-Line Treatments

Author

Nicolazzo, Chiara, primary, Gelibter, Alain, additional, Bottillo, Irene, additional, Belardinilli, Francesca, additional, Pisegna, Simona, additional, De Renzi, Gianluigi, additional, Marinelli, Daniele, additional, Grammatico, Paola, additional, Cortesi, Enrico, additional, Giannini, Giuseppe, additional, and Gazzaniga, Paola, additional

Published
2021
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28. True conversions from RAS mutant to RAS wild-type in circulating tumor DNA from metastatic colorectal cancer patients as assessed by methylation and mutational signature

Author

Nicolazzo, Chiara, primary, Barault, Ludovic, additional, Caponnetto, Salvatore, additional, De Renzi, Gianluigi, additional, Belardinilli, Francesca, additional, Bottillo, Irene, additional, Bargiacchi, Simone, additional, Macagno, Marco, additional, Grammatico, Paola, additional, Giannini, Giuseppe, additional, Cortesi, Enrico, additional, Di Nicolantonio, Federica, additional, and Gazzaniga, Paola, additional

Published
2021
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29. Clinical utility of repeated circulating tumor cell (CTC) enumeration as early treatment monitoring tool in metastatic breast cancer (MBC) - a global pooled analysis with individual patient data

Author

Janni, Wolfgang J., Yab, Tracy C., Hayes, Daniel F., Cristofanilli, Massimo, Bidard, Francois-Clement, Ignatiadis, Michail, Regan, Meredith M., Alix-Panabieres, Catherine, Barlow, William E., Carlos Caldas, Carey, Lisa A., Dirix, Luc, Fehm, Tanja, Garcia-Saenz, Jose A., Gazzaniga, Paola, Generali, Daniele, Gerratana, Lorenzo, Gisbert-Criado, Rafael, Jacot, William, Jiang, Zefei, Lianidou, Evi, Magbanua, Mark J. M., Manso, Luis, Mavroudis, Dimitrios, Muller, Volkmar, Munzone, Elisabetta, Pantel, Klaus, Pierga, Jean-Yves, Rack, Brigitte, Riethdorf, Sabine, Rugo, Hope S., Sideras, Kostandinos, Sleijfer, Stefan, Smerage, Jeffrey, Stebbing, Justin, Terstappen, Leon W. M. M., Vidal-Martinez, Jose, Zamarchi, Rita, Giridhar, Karthik, Friedl, Thomas W. P., and Liu, Minetta C.

Published
2021

34. Abstract GS4-08: Clinical utility of repeated circulating tumor cell (CTC) enumeration as early treatment monitoring tool in metastatic breast cancer (MBC) - a global pooled analysis with individual patient data

Author

Janni, Wolfgang J, primary, Yab, Tracy C., additional, Hayes, Daniel F., additional, Cristofanilli, Massimo, additional, Bidard, Francois-Clement, additional, Ignatiadis, Michail, additional, Regan, Meredith M., additional, Alix-Panabières, Catherine, additional, Barlow, William E., additional, Caldas, Carlos, additional, Carey, Lisa A., additional, Dirix, Luc, additional, Fehm, Tanja, additional, Garcia-Saenz, Jose A., additional, Gazzaniga, Paola, additional, Generali, Daniele, additional, Gerratana, Lorenzo, additional, Gisbert-Criado, Rafael, additional, Jacot, William, additional, Jiang, Zefei, additional, Lianidou, Evi, additional, Magbanua, Mark J.M., additional, Manso, Luis, additional, Mavroudis, Dimitrios, additional, Müller, Volkmar, additional, Munzone, Elisabetta, additional, Pantel, Klaus, additional, Pierga, Jean-Yves, additional, Rack, Brigitte, additional, Riethdorf, Sabine, additional, Rugo, Hope S., additional, Sideras, Kostandinos, additional, Sleijfer, Stefan, additional, Smerage, Jeffrey, additional, Stebbing, Justin, additional, Terstappen, Leon W.M.M., additional, Vidal-Martínez, José, additional, Zamarchi, Rita, additional, Giridhar, Karthik, additional, Friedl, Thomas W.P., additional, and Liu, Minetta C., additional

Published
2021
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37. Circulating Methylated DNA to Monitor the Dynamics of RAS Mutation Clearance in Plasma from Metastatic Colorectal Cancer Patients

Author

Nicolazzo, Chiara, primary, Barault, Ludovic, additional, Caponnetto, Salvatore, additional, Macagno, Marco, additional, De Renzi, Gianluigi, additional, Gradilone, Angela, additional, Belardinilli, Francesca, additional, Cortesi, Enrico, additional, Di Nicolantonio, Federica, additional, and Gazzaniga, Paola, additional

Published
2020
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41. Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer

Author

Nicolazzo, Chiara, primary, Loreni, Flavia, additional, Caponnetto, Salvatore, additional, Magri, Valentina, additional, Vestri, Anna Rita, additional, Zamarchi, Rita, additional, Gradilone, Angela, additional, Facchinetti, Antonella, additional, Rossi, Elisabetta, additional, Cortesi, Enrico, additional, and Gazzaniga, Paola, additional

Published
2020
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43. Serial Analysis of Circulating Tumor Cells in Metastatic Breast Cancer Receiving First-Line Chemotherapy

Author

Magbanua, Mark Jesus M, primary, Hendrix, Laura H, additional, Hyslop, Terry, additional, Barry, William T, additional, Winer, Eric P, additional, Hudis, Clifford, additional, Toppmeyer, Deborah, additional, Carey, Lisa Anne, additional, Partridge, Ann H, additional, Pierga, Jean-Yves, additional, Fehm, Tanja, additional, Vidal-Martínez, José, additional, Mavroudis, Dimitrios, additional, Garcia-Saenz, Jose A, additional, Stebbing, Justin, additional, Gazzaniga, Paola, additional, Manso, Luis, additional, Zamarchi, Rita, additional, Antelo, María Luisa, additional, Mattos-Arruda, Leticia De, additional, Generali, Daniele, additional, Caldas, Carlos, additional, Munzone, Elisabetta, additional, Dirix, Luc, additional, Delson, Amy L, additional, Burstein, Harold J, additional, Qadir, Misbah, additional, Ma, Cynthia, additional, Scott, Janet H, additional, Bidard, François-Clément, additional, Park, John W, additional, and Rugo, Hope S, additional

Published
2020
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