1. Prevalence and Factors Associated With Statin Use Among Patients With Nonalcoholic Fatty Liver Disease in the TARGET-NASH Study
- Author
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Thomson, Mary J, Serper, Marina, Khungar, Vandana, Weiss, L Michael, Trinh, Huy, Firpi-Morell, Roberto, Roden, Michael, Loomba, Rohit, Barritt, A Sidney, Gazis, Derek, Mospan, Andrea R, Fried, Michael W, Reddy, K Rajender, and Lok, Anna S
- Subjects
Cardiovascular ,Chronic Liver Disease and Cirrhosis ,Liver Disease ,Prevention ,Clinical Research ,Rare Diseases ,Hepatitis ,Digestive Diseases ,Oral and gastrointestinal ,Good Health and Well Being ,Humans ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Liver Cirrhosis ,Liver Neoplasms ,Non-alcoholic Fatty Liver Disease ,Prevalence ,Clinical Sciences ,Gastroenterology & Hepatology - Abstract
Patients with nonalcoholic fatty liver disease (NAFLD) are at an increased risk of cardiovascular disease. Hydoxy-3-methyglutaryl-coenzyme reductase inhibitors, statins, reduce the risk of cardiovascular events.1 Studies have shown that statins are safe among patients with liver disease, including those with compensated cirrhosis,2 and their use is associated with lower mortality, hepatic decompensation, and possibly hepatocellular carcinoma.3,4 Despite these data, statins are under prescribed among patients with liver disease due to concerns about hepatotoxicity.5 This study aimed to assess prevalence and patient factors associated with indicated statin use in patients with NAFLD in a real-world cohort.
- Published
- 2022