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3. Structural and molecular basis of choline uptake into the brain by FLVCR2

Author

Cater, Rosemary J., Mukherjee, Dibyanti, Gil-Iturbe, Eva, Erramilli, Satchal K., Chen, Ting, Koo, Katie, Santander, Nicolás, Reckers, Andrew, Kloss, Brian, Gawda, Tomasz, Choy, Brendon C., Zhang, Zhening, Katewa, Aditya, Larpthaveesarp, Amara, Huang, Eric J., Mooney, Scott W. J., Clarke, Oliver B., Yee, Sook Wah, Giacomini, Kathleen M., Kossiakoff, Anthony A., Quick, Matthias, Arnold, Thomas, and Mancia, Filippo

Published
2024
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9. The Structure of the Concepts Related to Love Spectrum: Emotional Verbal Fluency Technique Application, Initial Psychometrics, and Its Validation

Author

Gawda, Barbara

Abstract

Love has been thoroughly studied and a variety of definitions as well as types of love have been described in the literature. Given the data presenting natural language of love concept, the aim of the two present studies is to demonstrate a new technique which enables description of the structure of emotion concepts within love spectrum. This technique is based on emotional verbal fluency tasks. The procedure and the coding system used are reported in the article along with the data on reliability and standardization of the emotional verbal fluency technique. Construct validity is demonstrated by correlations of the emotional verbal fluency tasks with semantic and letter verbal fluency tasks, while discriminant validity is shown by correlations with other measures, such as the Triangular Love Scale, the Love Attitudes Scale, and the State-Trait Anxiety Inventory. The article also presents how the emotional verbal fluency technique can be used in exploring the structure of emotion concepts within love spectrum. This is based on a hierarchical cluster analysis. An examination of connections between semantic clusters identified in the emotional verbal fluency tasks allows describing a structure of the concepts within love spectrum, such as "liking," "infatuation," "love," and show of its differentiation. The presented technique taking into account natural language is of value in assessments of the structure of emotion concepts.

Published
2019
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11. Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype

Author

Kojic, Marija, Gawda, Tomasz, Gaik, Monika, Begg, Alexander, Salerno-Kochan, Anna, Kurniawan, Nyoman D., Jones, Alun, Drożdżyk, Katarzyna, Kościelniak, Anna, Chramiec-Głąbik, Andrzej, Hediyeh-Zadeh, Soroor, Kasherman, Maria, Shim, Woo Jun, Sinniah, Enakshi, Genovesi, Laura A., Abrahamsen, Rannvá K., Fenger, Christina D., Madsen, Camilla G., Cohen, Julie S., Fatemi, Ali, Stark, Zornitza, Lunke, Sebastian, Lee, Joy, Hansen, Jonas K., Boxill, Martin F., Keren, Boris, Marey, Isabelle, Saenz, Margarita S., Brown, Kathleen, Alexander, Suzanne A., Mureev, Sergey, Batzilla, Alina, Davis, Melissa J., Piper, Michael, Bodén, Mikael, Burne, Thomas H. J., Palpant, Nathan J., Møller, Rikke S., Glatt, Sebastian, and Wainwright, Brandon J.

Published
2021
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15. Valence of Affective Verbal Fluency: fMRI Studies on Neural Organization of Emotional Concepts 'Joy' and 'Fear'

Author

Gawda, Barbara, Szepietowska, Ewa, Soluch, Pawel, and Wolak, Tomasz

Abstract

The present study was designed to examine the underlying brain mechanisms of positive and negative emotional verbal fluency. Three verbal fluency tasks (one non-emotional phonemic task, two emotional tasks: "Joy" and "Fear") were used in this study. The results were analyzed for 35 healthy, Polish-speaking, right-handed adults aged 20-35. Functional magnetic resonance imaging (3T) was used to show brain activity during active participation in emotional verbal fluency tasks. The results reported for emotional fluency confirmed activation of different brain regions for the negative and positive emotional verbal fluency: in positive emotional verbal fluency "Joy" elicits greater activation in the frontal regions and the cingulate cortex, while in negative verbal fluency "Fear" is reflected in activation of parietal and temporal areas. The study provides an evidence for differentiation in neural mechanisms between positive and negative emotional verbal fluency and/or positive and negative retrieving processes, and differentiation in brain-related determinants of the emotional concepts organization.

Published
2017
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20. The Emotional Lexicon of Individuals Diagnosed with Antisocial Personality Disorder

Author

Gawda, Barbara

Abstract

This study investigated the specific emotional lexicons in narratives created by persons diagnosed with antisocial personality disorder (ASPD) to test the hypothesis that individuals with ASPD exhibit deficiencies in emotional language. Study participants consisted of 60 prison inmates with ASPD, 40 prison inmates without ASPD, and 60 men without antisocial tendencies who described situations involving love, hate and anxiety depicted by photographs. The lexical choices made in the narratives were analyzed, and a comparison of the three groups revealed differences between the emotional narratives of inmates with ASPD, inmates without ASPD, and the control group. Although the narratives of the individuals with ASPD included more words describing emotions and higher levels of emotional intensity, the valence of these words was inappropriate. The linguistic characteristics of these narratives were associated with high levels of psychopathy and low emotional reactivity.

Published
2013
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21. Extracorporeal Life Support Organization Registry International Report 2022: 100,000 Survivors

Author

Tonna, Joseph E., Boonstra, Philip S., MacLaren, Graeme, Paden, Matthew, Brodie, Daniel, Anders, Marc, Hoskote, Aparna, Ramanathan, Kollengode, Hyslop, Rob, Fanning, Jeffrey J., Rycus, Peter, Stead, Christine, Barrett, Nicholas A., Mueller, Thomas, Gómez, Rene D., Malhotra Kapoor, Poonam, Fraser, John F., Bartlett, Robert H., Alexander, Peta M.A., Barbaro, Ryan P., Abbasi, Adeel, Said Abdalmohsen, Ahmad, Abdelbary, Akram M., Abecasis, Francisco, Abel, Peter, Abu-Omar, Yasir, Adams, Douglas R, Manuel Africano, Juan, Aganga, Devon, Agati, Salvatore, Agerstrand, Cara, Aguillon, Mario V., Akers, Crystal S., Akhtarekhavari, Julia, Alazzam, Mohammad Izzat Salah, Albert, Martin, Alberti, Angela, Al-Fares, Abdulrahman A., Alfoudri, Huda, Allaert, Silvie, Allbert, Keesha N., Allen, Christopher T., Lescano Alva, Miguel Ángel, Alwardt, Cory M., Amigoni, Angela, Anandamurthy, Balaram, Anastasiadis, Kyriakos, Anders, Nicholas R., Anderson, Scott A., Anderson, Patricia L., Andrijević, Ana, Annoni, Alice, Anselmi, Michael, Anstey, James R., Antonini, Marta V., Antonitsis, Polychronis, Stein Araujo, Tays, Arcalas, Rhodney, Areinamo, Igor, Martin Arias, Anibal, Armijo-Garcia, Veronica, Aronsky, Vladimir, Arora, Lovkesh, Arora, Madhur, Leigh Aspenleiter, Marit, Atik, Fernando A., AugustGeorg Auzinger, Erin Colleen, Azzam, Ismail, Bacchetta, Matthew, Bak, Erica I., Balcells, Joan, Sánchez Ballesteros, Jesús, Banjac, Igor S., Barbaria, Jacqueline M., Barrigoto, Cleide L., Bass, Stephanie D., Batranović, Uroš, Bauer, Matthew H., Fernando Bautista, Diego, Beck, Robert M., Giraldo Bejarano, Estefania, Belohlavek, Jan, Bembea, Melania M., Benes, Jan, Benharash, Peyman, Benish, Lynne A., Bennett, Suzanne, Bento, Luís F.N., Bermudez, Christian A., Bertini, Pietro, Best, Derek, Bharat, Ankit, Bhutta, Omar J., Bizzell, Samantha J., Blakeman, Stephanie A., Blanco-Schweizer, Pablo, Blanton, Jessica K., Blood, Peggy S., Bohlmann, Allison S., Kyle Bohman, John, Bombino, Michela, Kathleen Bonadonna, Desiree, Bond, Ashley, Borgmann, Kristina M., Bourgoin, Pierre, Boville, Brian M., Boza, Raquel, Brady, Heather L., Brady, Alison, Braunlich, Jessica M., Bridges, Brian C., Brinkley, Karen K., Brookshire, Robert S., Brozzi Nicole Brueggemann, Nicolas A., Buckley, Dwight P., Buckley, Klayton, Budhani, Irfan B., Bukamal, Nazar, Burgos, Lucrecia M, Burša, Filip, Busby, Landon K., Buscher, Hergen, Butler, Menoly, Butt, Warwick W., Byrnes, Jonathan W., Calaritis, Christos, Caldwell, Lisa R., Calligaro, Gregory L., Campbell, Patrick T., Camporota, Luigi, Fernando Caneo, Luiz, Jovo Carapic, Vladimir, Carrasco-Carrasco, Cristina, Ivan Carrizo, Nestor, Carrow, Heidi, Carton, Edmund G., Casabella, Christian, Gomez Casal, Vanesa, Casey, Francis L., Castillo, Andres, Castleberry, Anthony W., Alexandros Cavayas, Yiorgos, Cerqua, Karey, Ming Chan, Kai Man ChanWai, Brian Chapman, Jason, Brahma Chari, Hari, Cheifetz, Omair ChaudharyIra M., Chen, Robin H.S, Chen, Weiting, Cheung, Eva W., Cheung, Anson, Chico, Juan I., Chiletti, Roberto, Jin Cho, Hwa, Cholette, Jill M., Christensen, Steffen, Chui, Betty S., Circelli, Alessandro, Clement, Katherine C., Cleuziou, Julie, Clouse, Brian, Cole, Gwendolen, Coles, Garrett M., Collins, Monika F., Collins, Monika F., Connelly, James, Conrad, Steven A., Cook, Marlene, Copeland, Hannah, Copus, Scott C., Cox, Charles S., Craig, Lynne K., Crain, Natasha, Cremonese, Ricardo V., Criswell, Emily A., Cross, Lisa M., Crowley, Moira A., Crowley, Jerome C., Cruz, Leonora, Cypel, Marcelo, Czarnik, Tomasz, Czuczwa, Miroslaw E., Sica da Rocha, Taís, Daddow, Samuel, Dali, Dante C., Dalton, Heidi J., Daly, Kathleen J.R., Damuth, Emily, Daniel, Dennis A., Daniel IV, John M., Daniel, Josiane M., Danis, Max D., Danko, Melissa E., Rodrigues Dantas, Joao Alberto, Daoust, Isabelle, Dauwe, Dieter F., Davidson, Mark, Davis, Joel C., Davis, Mitchell, D’Cunha, Jonathan, de Arruda Bravim, Bruno, de BoodeKim T. De La Cruz, Willem P., Gray DeAngelis, Kathryn, Debeuckelaere, Gerdy, Deitemyer, Matthew A., DellaVolpe, Jeffrey, Deneau, Jamie L., DeNino, Walter F., Denmark, Christopher G., Denney, Derek, DeValeria, Patrick A., Dewulf, Petra, Di Nardo, Matteo, DiBardino, Daniel J., DiMartino, Joseph, Dimopoulos, Stavros, Domico, Michele B., Dominy, Meaghan E., Donker, Dirk W., Dresbach, Till, Droogh, Joep M., Dunlap, Tiffany W., Dupon, Allsion, Durham, Lucian A., Durward, Andrew, Dvorak, Anna, Dyett, John F., Dziedzina, Carol L., Eaken, Carmen L., Eaton, Jonathan S., Eberle, Christopher J., Edwards, Linda, Efseviou, Christakis, Eigner, Juliann M., Ahmed Elhamrawi, Hazem, Elhazmi, Alyaa M., Elizondo, Tammy, Ellersick, Beverly L., Emling, Jonathan A., Ernst, Andreas, Pablo Escalante, Juan, Espinoza, Otoniel, Evey, Lee W., Fan, Eddy, Fang, Gary, Faulkner, Gail M., Fauman, Karen R, Ferguson, Niall, Ferreira, Benigno, Fiane, Arnt E., Andrade Fierro, Dario, Martha Filippi, María, Findeisen, Michael C., Finlay, Katie, Finlayson, Gordon, Fischer, Gwenyth A., Fischer, Courtney D., Fischer, William J., Fisher, Caleb M., Fitriasari, Reni, Fitzgerald, Jillian, Fix, Melissa K., Fleming, Sarah B., Flynn, Brigid C., Forst, Beth A., Fortuna, Philip P., Foti, Giuseppe, Fox, Matthew P., Franco, Thais O., David Freeland, C., Fried, Justin A., Friedman, Matthew L., Furlanetto, Beatriz, Fux, Thomas, Gaião, Sérgio, Gale, Michael J., Garcia, Joann Kathleen G., Garcia-Montilla, Romel, Gardner, Eric R., Garg, Meena, Garrison, Lawrence L., Gavrilovic, Srdjan M., Gawda, Ryszard, Geer, Laura W., Gelandt, Elton A., Gelvin, Michael G., Genovese, Bradley M., George, Jeffrey A., George, Timothy J, George, Sangley, Ghimire, Anup, Giani, Marco, Gill, Baljit S., Glikes, Erin, Golecki, Michael, Gongora, Enrique, Govener, Sara, Graf, Amanda, Grasselli, Giacomo, Gray, Brian W., Greenlee, Joseph A., Gregoric, Igor D., Gregory, Melinda, Grins, Edgars, Volker Groesdonk, Heinrich, Group, Kimberly F., Guarracino, Fabio, Joy Guidi-Solloway, Alexandra, Gunn, Tyler M., Guru, Pramod K, Haddle, John C., Haft, Jonathan W., Haisz, Emma, Hall, Julie L., Hall, Cameron, Hamaguchi, Jun, Hammond, Terese C., Han, Peggy K., Hardison, Daphne C., Harischandra, Dickwelle T., Hart, Shaun M., Harting, Matthew T., Hartley, Louise, Harvey, Chris J., Hasan, Zubair, Fawzy Hassan, Ibrahim, Hastings, Jennifer R., Hatcher, Renee’, Hatton, Kevin W., Haught, Christopher K., Awori Hayanga, Jeremiah, Peter Haydon, Timothy, Healy, Aaron H., Heard, Micheal L., Heather, Beth M., Hendrix, Rik H.J., Hennig, Felix, Hermens, Greet HermansJeannine A.J., Hernandez, Deborah A., Hernandez-Montfort, Jaime, Herrera, Guillermo, Hickman, Keri, Hittel, Ashley, Hobbs, Crystal, Hoffman, Jordan R.H., Hollinger, Laura E., Homishak, Michael, Horigoshi, Nelson K., Hoshino, Kota, Huang, Shu-Chien, Huenges, Katharina, Hussey, Alexander D., Hyslop, Robert W., Ihle, Rayan E., Ingemansson, Ola, Ivulich, Daniel, Jackson, Amanda L., Garcia Jacques, Rogelio, Jain, Harsh, Jakobs, Sharon M., Jan, Robert, Janowiak, Lisa M., Jara, Claire B., Jarden, Angela M., Jarzembowski, Jamie L., Jaudon, Andrew, Kishore Jayanthi, Venkata Krishna, Jennings, Joseph A., Jeong, Inseok, Meza Jiménez, Rafael, Jimenez-Rodriguez, Gian M., Joachim, Sabrina, Joelsons, Daniel, Johnson, Caroline A., Johnson, Andrea L., Jones, Jeffry H., Joseph, Mark, Joseph, Sunimol, Joshi, Raja, Joyce, Christopher J., Seung Jung, Jae, Carone Junior, José, Kallas, Harry J., KamerkarPilje Kang, Asavari, Kar, Biswajit, Karapanagiotidis, Georgios T., Kattan, Javier, Kaufman, David A., Kawauchi, Akira, Keene, Sarah D., Keller, Norma M., Keller, Roberta, Kelley, Emily W., Kelley, Kellie, Kelly-Geyer, Janet F., Kenderessy, Peter, Kenny, Laura E., Keshavjee, Shaf, Kessel, D., Kessler, Heather, Keuler, Suzanne, Khicha, Sanjay, Wan Kim, Do, Kim, Richard Y., Maxwell Kime, Aaron, Kincade, Robert C., Kipfmueller, Florian, Kirk, Douglas A., Klein, Liviu, Knapp, Randall S., Knapp, Randall S., Kneyber, Martin C.J., Knowles, Andrea L., Koch, Jillian M., Koepke, Stephanie, Kogelmann, Klaus M., Elzo Kraemer, Carlos, Krauklis, Amanda, Krumroy, Samantha L., Kumar, Madhan, Kumar, Arun, Kumpf, Matthias E, Kyle, Kimberly, Laffin, Anna, Kees Lagrand, Wim, Lahiji, Parshawn A., Keung Lai, Peter Chi, Ka Lai, Cally Ho, Danielle Laird, Amanda, Landsberg, Michelle LaMarreDavid M., Lanmueller, Pia, Oude Lansink-Hartgring, Annemieke, Beth Larson, Sharon, Laufenberg, De’Ann M., Lavana, Jayshree, Layne, Tracie L., John Lazar, Michael, Ledoux, Matthew R., Lee, Raymond C., Leek, Thomas M., Lequier, Laurance, Lesbekov, Timur, Leslie, Robert, Anne Leung, Kit Hung, Lillie, Jon, Phang Lim, Yeong, Lim, Sang-Hyun, Lin, Ling, Lindsey, Thomas, Ho Ling, Steven Kin, Lingle, Kaitlyn J., Lipes, Jed, Liu, Songqiao, Llevadias, Judit, Lomas, Erin A., Longenecker, Robert D., Lorusso, Roberto, Ann Low, Tracy, Steven Lubinsky, Anthony, Lucas, Matthias LubnowMark T., Lucchini, Alberto, Luze, Lisa E., Lynch, William R., Manoj, M.C., Maas, Jacinta J., MacNamara, Vanessa, Madden, Jesse L., Maimone, Justin, Malhotra, Rajiv, Malone, Matthew P., Mangukia, Chirantan, Manzur-Sandoval, Daniel, Maráczi, Veronika, Marinaro, Jonathan L., Marinucci, Christina R., Marshall, Tammy, Martin, Mark, Marwali, Eva M., Maslach-Hubbard, Anna, Matijašević, Jovan, Mattke, Adrian, Mattucci, Joseph, Maul, Timothy M., Maybauer, Marc O., Mayette, Michael, Mayville, Joni R., McAllister, Catherine, McBride, Martha W., Scott McCaul, David, McClelland, Samantha L.S., Gregory McCloskey, Colin, McGregor, Randy, McKamie, Wesley A., McKee, Andrew D., McMahon, Chelsea M., McMullin, Kaye, McNicol, Jane, McNulty, John P., McRae, Thomas, Meade, Maureen E., Meersseman, Philippe, Mekeirele, Michael, Ito Mendes, Elisa, Menon, Anuradha P., Meyer, Jason P., Meyers, Jourdan E., Meyns, Bart, Mignone, John L., Miller, Brittany D., Miller, Malcolm G.A., Miller, Deborah, Mintak, Renee, Minter, Sarah M., Reis Miranda, Dinis, Mirza, Farrukh, Mishkin, Joseph D., Modelewski, Paul, Mohan, Rajeev C., Hui Mok, Yee, Money, Dustin, Monteagudo, Julie, Moores, Russell R., Moran, Patrick, Morelock, Shawn, Moreno, Marsha R., Blanco Morillo, Juan, Morrison, Tracy, Morton, John M., Morton, Brenda, Moscatelli, Andrea, Mosier, Jarrod M., Muellenbach, Ralf M., Mueller, Andreas, Mueller, Dale, Musca, Steven C., Nagpal, Dave, Najaf, Tasnim, Narasimhan, Mangala, Nater, Melissa, Natividad, Zynthia, Nedeljkov, Djordje, Nelson, Bryan D., Newman, Sally F., Newton, Debra E., Neyman, Jonathan L., George Ng, Wing Yiu, Nicholson, Meghan C., Nicolaas, Christine, Nix, Charlie, Nkwantabisa, Raymond, Nolan, Shirley, Norese, Mariano, Norton, Bridget M., Norton, Bridget M., O’Brien, Serena G., O’Callaghan, Maura, Oishi, Peter, O’Leary, Tony D., Olia, Salim E., O’Meara, Carlisle, Oppel, Emily E., Arias Ortiz, Julian, Oza, Pranay L., Ozment, Caroline P., Pacific, Marjorie, Pálizas, Fernando, Palmer, David, Paoletti, Luca, Pardo, Diego H., Paredes, Pablo, Patel, Thomas PasgaardMrunal G., Patel, Sandeep M., Patel, Vijay S., Patel, Brijesh V., PatelDrisya Paul, Sameer, Pawale, Amit A., Pearson, Nicole M., Renee Pearson, Crystal, Peek, Giles J., Pellecchia, Crescens M., Pellegrino, Vincent, Peperstraete, Harlinde, Perkins, Rebecca L., Perkins, Brandon, Peterec, Steven, Peterman, Claire, Phillips, Cooper W., Piekutowski, Richard R., Pilan, María L., Luisa Pilan, Maria, Mark Pincus, Jason, Pino, Melissa, Plambeck, Robert W., Plisco, Michael S., Plumley, Donald A., Plunkett, Mark D., Poffo, Robinson, Poh, Pei-Fen, Polito, Angelo, Pollema, Travis L, Pozzi, Matteo, Pozzi, Matteo, Pranikoff, Thomas, Prekker, Matthew E., Prossen, Erik F., Puligandla, Pramod S., Puslecki, Mateusz, Raheel Qureshi, Muhammad, Emilia Rabanal, Lily, Abdulhamid Rabie, Ahmed, Rackley, Craig R., Radovancevic, Rajko, Raes, Matthias, Allen Raff, Lauren Desiree, Rahban, Youssef, Raimer, Patricia L., Rajbanshi, Bijoy G., Ramanan, Raj, Rambaud, Jerome, Ramírez-Arce, Jorge A., Simões Ramos, Ana Carolina, Rao, Suresh G., Rector, Raymond, Redfors, Bengt, Regmi, Ashim, Alejandro Rey, Jose, Miguel Ribeiro, Joao, Richards, Chelsea E, Joan Richardson, C., Riddle, Christy C., Riera, Jordi, Ripardo, Marina, Rivas, Fernando M., Roan, Ronald M., Robertson, Elizabeth, Robinson, Megan, Röder, Daniel, Rodrigus, Inez E.R., Paul Roeleveld, Peter, Romano, Jennifer C., Rona, Roberto, Ann Rosenberg, Carol, Rosenow, Felix, Rowe, Robert J., Rower, Katy E., Rudolph, Kristina L., Fernando Rueda, Luis, Ruf, Bettina, Russell, Hyde M., Russell, Nichole, Ryan, Kathleen, Saberi, Asif A., Said, Ahmed S., Sailor, Caitlin, Sakal, Angela, Lujan Salas, Gisela, Salazar, Leonardo, Saleem, Kashif, Samoukovic, Gordan, Sanchez, Pablo G., Marie Santiago, Lian, Sargin, Murat, Miguel Sassine, Assad, Satou, Nancy L., Saunders, Paul C., Schachinger, Scott, Schaible, Thomas, Schellongowski, Peter, Schlager, Gerald W., Schmid, Christof, Schmitt, Joachim, Schnell, LeeAndra, Schnur, Janos, Schroeder, Lukas, Schubach, Scott, Schuetz, Michael T., Schwartz, Gary S., Schwarz, Patricia, Scriven, Nicole M., Seabrook, Ruth B., Seefeldt, Cassandra, Seelhammer, Troy G., Segura-Matute, Susana, Sen, Ayan, Adrian Seoane, Leonardo, Shaffer, Jamie, Shafi, Bilal M., Shambley, Shannon, Shankar, Shyam, Shapland, Amanda, Sharng, Yih, Shavelle, David, Sheldrake, Jayne, Mohan Shetty, Rajesh, Shiber, Joseph R., Shimzu, Naoki, Lou Short, Billie, Sichting, Kay A., Sidehamer, Keith E., Siebenaler, Teka, Silvestry, Scott C., Sinclair, Jennifer T, Sinclair, Andrew, Singh, Aalok R., Singh, Gurmeet, Skinner, Sean C., Smart, Alexandra, Smith, Reanna M., Smith, Adam, Smith, Karen, Sommer-Candelario, Sherri, Song, Seunghwan, Sorensen, Gro, Sousa, Eduardo, Sower, Christopher T., Spadea, Nicholas V, Spangle, April, Speicher, David G., Spieth, Peter M., Srivastava, Ankur, Srivastava, Neeraj, Stahl, Mark, Stallkamp, Eric D., Stanley, Vanessa J., Starr, Joanne P., Staudinger, Thomas, Stevens, Berkeley E., Stevens, Kimberly, Stocker, Christian, Strickland, Richard, Suarez, Erik E., Kumar Subramanian, Rakesh, Sudakevych, Serhii, Summerall, Charlene, Sundararajan, Santosh, Susupaus, Attapoom, Suzuki, Hiroyuki, Sweberg, Todd, Sydzyik, Troy, Anh Ta, Tuan, Tagliari, Luciana, Tanaka, Hiroyuki, Tanski, Christopher T., Tasset, Mark, Taylor, Donna M., Teman, Nicholas R., Ramesh Thangaraj, Paul, Thiagarajan, Ravi R., Thiruchelvam, Timothy, Thomas, James A., Thomas, Owain D., Thompson, Shaun L., Thomson, David A., Thukaram, Roopa, Todd, Mark L., Toeg, Hadi, Torres, Silvio F., Trautner, Simon, Trombino, Terry, Tuazon, Divina M., Tuel, Julie, Tukacs, Monika, Turner, April N., Tyree, Melissa M., Uchiyama, Makoto, Vaijyanath, Prashant, van den Brule, Judith M.D., van Dyck, Marlice A., van Gijlswijk, Mascha, Van Meurs, Krisa P., VanDyck, Tyler J., Vardi, Amir, Vega, Alejandra, Ventetuolo, Corey E., Vera, Magdalena, Vercaemst, Leen, Vets, Philippe, Viamonte, Heather, Vidlund, Mårten, Vitali, Sally H., Vlaa, Alexander P.J., Vuylsteke, Alain, Loon Wan, Kah, Watkins, Reuben, Watson, Pia, Weast, Travis A., Weaver, Karen E., Welkovics, Norbert, Wellner, Heidi L., Wells, Jason C., Welter, Karen, Westpheling, Amber G., Whalen, Lesta D.S., Whebell, Stephen, Wiersema, Ubbo, Wiisanen, Matthew E., Eugene Wilcox, Bradley, Wille, Keith, Jan Will, Ellyne, Wilson, Brock J., Win, April M., Winearls, James R., Wise, Linda J., Witter, Tobias, Ruby Wong, Hoi Mei, Worku, Berhane, Wright, Tina M, Wu, James K., Yalon, Larissa A., Yantosh, Garrett, Yaranov, Dmitry M., Yee, Pat, Yi, Cassia, Yost, Christian C., Young, John, Younger, Katrina, Zaborowski, Steven, Zachmann, Brenda, Zainab, Asma, Zanai, Rosanna, Zhao, Ju, Zhou, Chengbin, and Zinger, Marcia

Abstract

The Extracorporeal Life Support Organization (ELSO) maintains the world’s largest extracorporeal membrane oxygenation (ECMO) registry by volume, center participation, and international scope. This 2022 ELSO Registry Report describes the program characteristics of ECMO centers, processes of ECMO care, and reported outcomes. Neonates (0–28 days), children (29 days–17 years), and adults (≥18 years) supported with ECMO from 2009 through 2022 and reported to the ELSO Registry were included. This report describes adjunctive therapies, support modes, treatments, complications, and survival outcomes. Data are presented descriptively as counts and percent or median and interquartile range (IQR) by year, group, or level. Missing values were excluded before calculating descriptive statistics. Complications are reported per 1,000 ECMO hours. From 2009 to 2022, 154,568 ECMO runs were entered into the ELSO Registry. Seven hundred and eighty centers submitted data during this time (557 in 2022). Since 2009, the median annual number of adult ECMO runs per center per year increased from 4 to 15, whereas for pediatric and neonatal runs, the rate decreased from 12 to 7. Over 50% of patients were transferred to the reporting ECMO center; 20% of these patients were transported with ECMO. The use of prone positioning before respiratory ECMO increased from 15% (2019) to 44% (2021) for adults during the coronavirus disease-2019 (COVID-19) pandemic. Survival to hospital discharge was greatest at 68.5% for neonatal respiratory support and lowest at 29.5% for ECPR delivered to adults. By 2022, the Registry had enrolled its 200,000th ECMO patient and 100,000th patient discharged alive. Since its inception, the ELSO Registry has helped centers measure and compare outcomes across its member centers and strategies of care. Continued growth and development of the Registry will aim to bolster its utility to patients and centers.

Published
2024
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22. Structural insights into translocation and tailored synthesis of hyaluronan

Author

Górniak, Ireneusz, Stephens, Zachery, Erramilli, Satchal K., Gawda, Tomasz, Kossiakoff, Anthony A., and Zimmer, Jochen

Abstract

Hyaluronan (HA) is an essential component of the vertebrate extracellular matrix. It is a heteropolysaccharide of N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcA) reaching several megadaltons in healthy tissues. HA is synthesized and translocated in a coupled reaction by HA synthase (HAS). Here, structural snapshots of HAS provide insights into HA biosynthesis, from substrate recognition to HA elongation and translocation. We monitor the extension of a GlcNAc primer with GlcA, reveal the coordination of the uridine diphosphate product by a conserved gating loop and capture the opening of a translocation channel to coordinate a translocating HA polymer. Furthermore, we identify channel-lining residues that modulate HA product lengths. Integrating structural and biochemical analyses suggests an avenue for polysaccharide engineering based on finely tuned enzymatic activity and HA coordination.

Published
2024
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23. Syntax of Emotional Narratives of Persons Diagnosed with Antisocial Personality

Author

Gawda, Barbara

Abstract

The aim of this study was to show some specificity of syntax of narratives created by persons diagnosed with antisocial personality. The author attempted to verify and supplement information that persons with antisocial personality have an incapacity for emotional language. Scores of 60 prisoners with high antisocial tendencies, 40 prisoners with low antisocial tendencies, and 100 men without the antisocial tendencies, were analyzed. The participants had to describe the situations of love, hate and anxiety inspired by the photographs. The narrative discourse was analyzed. The research was concentrated on syntactic elements. Comparisons between the three groups were conducted. The results show the differences between the antisocial inmates, non-antisocial inmates, and controls. In their emotional narratives, the antisocial individuals used more repetitions, pauses and negations. These linguistic characteristics are attributed to high activity, psychopathy and emotionality of persons diagnosed with antisocial personality.

Published
2010
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28. Health Consciousness vs. Disease. Polish Adaptation of the Health Consciousness Scale by Ch.S.Hu

Author

Księska-Koszałka, Joanna Małgorzata and Gawda, Barbara

Abstract

Introduction:Health consciousness is a theoretical construct that, depending on the concept, constitutes a psychological structure expressed primarily in the cognitive and behavioural sphere. It determines how individuals respond to health issues and the extent to which they are ready to take action to improve them. The level of health consciousness in the patient and his/her family has an impact on the achieved therapeutic effects. Due to the lack of an analogous tool for testing health consciousness in the Polish literature on this subject, the research objective was to create a Polish adaptation of the Ch.S.Hu Health Consciousness Scaleand determine its psychometric properties.

Published
2022
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29. Analysis of changes in electromyographic masticatory muscle activity in relation to the selected correction of refractive error.

Author

Zieliński, Grzegorz, Baszczowski, Michał, Ginszt, Michał, Rapa, Maria, Matysik-Woźniak, Anna, Szkutnik, Jacek, Rejdak, Robert, and Gawda, Piotr

Abstract

Wearing glasses is safe, effective, and the most popular method in correcting myopia. The study aimed to analyze the changes in electromyographic activity of the masticatory muscles about the selected correction of refractive error. Two muscle pairs were analyzed: the anterior part of the temporalis muszle and the superficial part of the masseter muscle. The patient was fitted with 20/200, 20/40 20/20, 20/10 corrections of refractive terror, and during each correction of refractive error, the changes in the recording of bioelectrical activity during rest, during maximal voluntary clenching, during maximal voluntary clenching on dental rollers were analyzed. With greater correction of refractive error, resting temporal muscle activity increases. Appropriate correction of refractive error may be an option in the treatment of masticatory muscle pathology. This phenomenon requires further research. [ABSTRACT FROM AUTHOR]

Published
2022
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30. Changes of the body posture in the sagittal plane of young adults during Matthiass test

Author

Kochman M, Zawadka M, Gawda P, and Jablonski M

Subjects
Orthodontics, medicine.anatomical_structure, Body posture, medicine, Young adult, Psychology, Sagittal plane, Test (assessment)
Abstract

Background Postural assessment is an important part of the physical examination in the physical therapy practice. One of the most commonly used clinical tests is an arm-raising Matthiass test. The aim of this study was to investigate posture changes in sagittal plane observed during Matthiass test in young adults using a rasterstereography method. Methods Fourteen young and healthy volunteers, nine female and four male aged between 21 and 25 took part in this study. Examination s performed with the rasterstereographic measuring device. Results Trunk inclination significantly decreased during Matthiass test and the pelvis inclination increased. Distance between kyphosis apex and cervical lordosis apex was significantly shorter during the test than in standing position. Distance between kyphosis apex and lumbar lordosis apex significantly increased during Matthiass test. Kyphosis angle was significantly decreased and the lumbar lordosis angle was increased during the test. Conclusion The results of this study suggest that Matthias test can cause significant deviations in posture in young participants. Changes in the sagittal plane are observed mainly right after the elevation of the arms.

Published
2019
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31. Allergic and non-allergic asthma in children hospitalized in the University Children’s Hospital in Lublin in 2016-2020

Author

Szuba, Joanna, Wawryk-Gawda, Ewelina, Brzuszkiewicz, Kinga, and Urbanska, Katarzyna

Abstract

Introduction.Bronchial asthma is a common disease characterized by chronic inflammation of the airways. Paediatric asthma is still a current problem and children with exacerbation frequently are hospitalized. The aim of the study was to determine the prevalence of allergic and non-allergic asthma in children hospitalized at the Department of Paediatric Pulmonology and Rheumatology of the University Children’s Hospital in Lublin in 2016-2020, and to analyze the most common allergens associated with allergic asthma.

Published
2022
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32. Diagnostic methods used in children with malocclusion

Author

Pałka, Justyna, Zieliński, Grzegorz, Gawda, Joanna, and Gawda, Piotr

Abstract

Introduction.With advances in technology, there has been a need for more precise imaging methods which have become an integral part of the orthodontic treatment plan.

Published
2021
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34. Influence of regular climbing on depression, generalized anxiety and lower back pain.

Author

Zieliński, Grzegorz, Zięba, Estera, Wilkowicz, Wiktor, Byś, Aleksandra, Ginszt, Michał, Libera, Oliwia, Zawadka, Magdalena, Saran, Tomasz, and Gawda, Piotr

Abstract

Introduction and objective. Anxiety and depression disorders are increasingly affecting society. Anxiety disorders are the most prevalent psychiatric disorders, and depressive disorders are increasing in society worldwide. Lower back pain is one of the common health problems experienced by 50–80% of adults at some point in their lives. The aim of the study was to assess the climbing environment in terms of depression, generalized anxiety and pain in the lumbar spine. Materials and method. 139 people training on climbing walls Lublin in December 2019 were invited to participate in the study. After applying exclusion criteria, 113 people with an average age of 30±8 years, 88 men (average age: 30 years) and 35 women (average age: 30 years) were qualified for the study. They were examined by the author’s own questionnaire and the PHQ-9, GAD-7 and ODI questionnaires. Statistical analyses were applied and the significance threshold was set at 0.05. Results. Overall percentage results suggest mild depression at 27%, moderate anxiety at 27%, and mild back pain at 26% in the group of climbers tested. Climbing level and climbing sub-discipline did not affect the average results of PHQ-9, GAD-7 (p>0.05). Back pain was more common in boulder climbers (p<0.05). Conclusions. The level of sport climbing did not affect the level of depression, generalized anxiety, and back pain. The sport climbing level did not affect the incidence of injuries. The association in climbing clubs is connected with overcoming more difficult climbing routes and a higher level of generalized anxiety. Bouldering was associated with a greater level of pain in the lumbar spine and more injuries. [ABSTRACT FROM AUTHOR]

Published
2021
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35. Sex differences in masticatory muscle activity in healthy young adults

Author

Ginszt, Michał, Zieliński, Grzegorz, Szkutnik, Jacek, Bakalczuk, Magdalena, Zawadka, Magdalena, Ginszt, Apolinary, Gawda, Piotr, and Majcher, Piotr

Abstract

Introduction.Several studies analyzed the gender differences in masticatory muscle activity. Previous scientific reports indicate the predominance of the masseter muscle activity in male subjects and the predominance of the temporalis anterior in women. However, there is a lack of studies analyzing the differences in the activity of the mandibular abduction muscles between men and women.

Published
2022
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36. Altered squat movement pattern in patients with chronic low back pain.

Author

Zawadka, Magdalena, Smołka, Jakub, Skublewska-Paszkowska, Maria, Łukasik, Edyta, Zieliński, Grzegorz, Byś, Aleksandra, and Gawda, Piotr

Abstract

Introduction and objective: Low back pain (LBP) is a problem which causes human suffering and entails costs for treatment. Chronic LBP is considered a civilization diseases in developed countries and one of the major public health problem worldwide. Squatting is a part of such daily activities as sitting down, standing up or lifting objects. In this study, hip, knee, and ankle joint motions during squatting are analyzed in the sagittal plane. The aim of the study was to find a relationship between the function of the lower limb during squatting and LBP incidence. Material and methods: Eleven healthy subjects and eight subjects suffering from low back pain were enrolled in tes study. Participants performed squat while maintaining heel contact with the ground throughout the movement. The participants attempted to make a squat as deep as possible. Kinematic data were captured using a Vicon optical motion capture system. Results: The low back pain group had a greater range of motion of the hip and knee with reference to the ankle joint motion, compared to the control group. There was no statistically significant difference in ankle dorsiflexion between groups. Control group reached maximal ankle dorsiflexion at higher point of descent than LBP group. Conclusions: The findings support the hypothesis that the strategy of movement is different in subjects with and without back pain. They may suggest that subjects with low back pain in maximal squat use the hip joint and knee joint to a greater extent than subjects without back pain, with comparable ankle dorsiflexion. Clinicians should take into consideration the influence of ankle motion and timing on exercise biomechanics in persons suffering from low back pain. [ABSTRACT FROM AUTHOR]

Published
2021
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37. Differences in myoelectric manifestations of fatigue during isometric muscle actions.

Author

Gawda, Piotr, Ginszt, Michał, Ginszt, Apolinary, Pawlak, Halina, and Majcher, Piotr

Abstract

Introduction. Muscle fatigue has been studied for a long time with the use of a wide variety of exercise models, protocols and assessment methods, among which surface electromyography (sEMG) is most commonly used. The main sEMG parameters (amplitude and frequency) are prevalently used to evaluate the level of muscle fatigue in static and dynamic contractions. Objective. The purpose of this study is to determine and compare 2 separate indices: IF1 basis of the sEMG signal amplitude analysis and IF2 basis of the sEMG median frequency analysis, related to muscles fatigue during an isometric contraction. Materials and method. The study was performed on 60 professional runners divided into 2 equal groups. The first group comprised sprinters, competing in short distance track and field events (100 and 200 meters). The second group consisted of middle-distance runners, competing in middle-distance track and field events (800 and 1,500 meters). The electrical activity of the VMO muscles of the right and left lower limbs was recorded simultaneously during isometric activity in a squatting position. The sEMG data was used to determine and compare IF1 and IF2 indices. Results. During isometric measurement, sprinters presented a much more significant increase in the mean amplitude of sEMG signal in comparison to middle-distance runners (mean IF1 difference: 0.228; p=0.007). Analysis of the median frequency did not show significant differences between the 2 groups (mean IF2 difference: 0.037; p=0.12). Conclusions. Change in sEMG amplitude during isometric exercise may be related to muscles fatigue. The use of fatigue indices, based on sEMG amplitude, as an objective indicator of the efficacy of an endurance training programme for sportsmen requires further research. [ABSTRACT FROM AUTHOR]

Published
2018
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38. Health training – preparing an organism for coping with COVID-19

Author

Gawda, Piotr, Zieliński, Grzegorz, Zawadka, Magdalena, and Byś, Aleksandra

Abstract

Coexistence of organisms in the world is a dynamic state, requiring complying with certain rules in order to sustain biological balance. Huge human expansion into the Earth ecosystem results in numerous crises. One of them is a problem of pandemic concerning COVID-19. The dynamics of epidemic development is changing. More and more statistical analyses regarding clinical course of this disease are appearing. Prophylactic actions, specific for each country, are taken aimed at reduction of quantity and intensity of infections in the society in such a way as to make health care systems efficient at the time of pandemic. Great hopes are put in natural defence mechanisms of human body, the effectiveness of which, to a large extent, depends on ourselves. As part of prophylactic actions, heath trainings, that is regular physical exercises together with proper management of rest, nutrition and sleep, can improve physical performance of an organism, strengthen its immuno-logical defence, adapting it to greater burdens. Such a relative load, that impairs functioning of respiratory system and as a consequence limits the ability to obtain energy necessary for independent maintenance of vital functions, may be a clinic course of COVID-19. Development of the Internet and social media considerably facilitates search for those kinds of physical activities that can be performed in the home. That is why, despite the isolation and movement restrictions, everyone can find own way to actively spend free time, which will positively influence his/her organism, and consequently, increase chances in potential encounter with the virus.

Published
2019
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39. Evaluation of interleukin-6 concentration in the liver of Albino Swiss mice after intoxication with various doses of patulin

Author

Borzecki, Pawel, Borzecka, Agnieszka, Chylinska-Wrzos, Patrycja, Lis-Sochocka, Marta, Wawryk-Gawda, Ewelina, and Jodlowska-Jedrych, Barbara

Abstract

Patulin is a mycotoxin produced by many species of the fungi. The toxic action of patulin mainly affects the gastrointestinal tract and the immune system. The aim of our work was to assess the toxic effect of patulin, based on the analysis of interleukin IL-6 concentrations in the liver of test animals loaded with different doses of this mycotoxin. The research was conducted on mice which were assigned to 6 groups receiving different doses of active substances. After decapitation, their livers were taken for laboratory testing.

Published
2019
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40. Severity of work in opinions of rural women living in the Bieszczady region of south-eastern Poland.

Author

Pawlak, Halina, Petkowicz, Beata, Maniak, Barbara, Kuna-Broniowska, Izabela, Petkowicz, Jacek, Buczaj, Agnieszka, Maksym, Piotr, Nowakowicz-Dębek, Bożena, and Gawda, Piotr

Abstract

Objective. The objective of the study was recognition of the opinions of rural women living in the Bieszczady region of south-eastern Poland, concerning their perception of the degree of severity of work. The study was conducted among the inhabitants of the Cisna commune. Materials and method. The basic research instrument was a questionnaire form containing 15 items. The study covered 101 women living in the Cisna commune in the Bieszczady. The self-reported degree of work load on a farm was analyzed among women who were occupationally active, and those who were not occupationally active. The effect of assistance from family members on the severity of work perceived by women was considered. Results. The women in the study focused on agro-tourism, a few of them were engaged in agricultural work and the majority worked in household gardens. The study showed that occupationally active women work considerably longer, on average, and are the most loaded, compared to those not engaged in occupational activity. The mean daily time devoted to duties on a farm did not significantly differ between occupationally active and non-active women, and amounted to 380 and 320 minutes, respectively. The majority of women who were non-active occupationally evaluated their household chores as the highest work load. In turn, the women who undertook occupational activity assessed them as most burdensome, despite great help from their family. The body positions assumed while performing field work were: standing, standing-bent-over, and walking. The mean evaluations of work load while standing and standing-bent-over did not significantly differ, but affected the work load among women who, however, could not assess the severity of their work resulting from the body position assumed. [ABSTRACT FROM AUTHOR]

Published
2018
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42. Apoptosis of rats’ cardiomyocytes after chronic energy drinks consumption

Author

Slawinski, Miroslaw Aleksander, Wawryk-Gawda, Ewelina, Zarobkiewicz, Michal Konrad, Halczuk, Pawel, and Jodlowska-Jedrych, Barbara

Abstract

Energy drinks (ED) are beverages containing caffeine, taurine, vitamins, herbal extracts, and sugar or sweeteners. They are marketed as capable of improving stamina, athletic performance and concentration, moreover, as serving as a source of energy. Still, there are very few papers describing the impact of ED on cell biology – including cell apoptosis within tissues. Therefore, in our study, we assessed the symptoms of rat cardiomyocytes apoptosis after 8 weeks consumption of ED.

Published
2018
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44. Vitamin D kinetics in the acute phase of critical illness: A prospective observational study

Author

Czarnik, Tomasz, Czarnik, Aneta, Gawda, Ryszard, Gawor, Maciej, Piwoda, Maciej, Marszalski, Maciej, Maj, Magdalena, Chrzan, Olimpia, Said, Rahim, Rusek-Skora, Maja, Ornat, Marta, Filipiak, Kamil, Stachowicz, Jakub, Kaplon, Robert, and Czuczwar, Miroslaw

Abstract

The objective of this study was to assess the vitamin D kinetics in critically ill patients by performing periodic serum vitamin D measurements in short time intervals in the initial phase of a critical illness.

Published
2018
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45. Burnout among students of medical universities in Poland

Author

Zarobkiewicz, Michał K., Sławiński, Mirosław A., Woźniakowski, Mateusz M., Wawryk-Gawda, Ewelina, Kulak-Janczy, Emilia, Korzeniowska, Sylwia, and Jodłowska-Jędrych, Barbara

Abstract

Introduction. Burnout among medical students have been thoroughly studied in a number of countries worldwide. Little is known about medical students burnout in the Central European countries. Material and methods. The study is based on the Copenhagen Burnout Inventory, adapted for measurement of burnout among medical students. The questionnaire contained 6 numerical scale questions about respondents’ satisfaction with studies, university and educational achievements. Students of Polish medical universities were recruited via closed Facebook groups of their faculties. As a result, 778 questionnaires were gathered and analysed. A cluster analysis was performed with the special cluster analysis tool of the Statistica 12 - six questions with numerical scale were used as cluster analysis variables. Results. Almost 19% of the subjects reported a high or very high total burnout rate - it was almost 40% for both personal and work-related burnout, but less than 5% for patient-related burnout. The cluster analysis revealed three distinctive groups - dissatisfied, middling and satisfied with their studies and university. For both the total and partial scores, the highest burnout was observed among the dissatisfied, the lowest among the satisfied, while the middling group had the average score. Discussion. A significant level of burnout among Polish medical students, reported in the current study, is consistent with results of numerous investigations performed worldwide. As only 5% of the respondents scored high in patient-related burnout, a question emerges as to whether burnout is more related to clinical subjects or to high learning load. Conclusions. The current study reveals a significant level of burnout among Polish medical students. Both improved education quality and interesting and innovative teaching methods may possibly prevent high burnout among medical students.

Published
2018
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46. Difference in vertical jumping abilities, endurance and quickness of regeneration lower extremity muscle groups after physical effort between CrossFit and climbing athletes

Author

Gawda, Piotr, Ginszt, Michał, Smołka, Jakub, Paćko, Michał, Skublewska-Paszkowska, Maria, Łukasik, Edyta, and Majcher, Piotr

Abstract

Introduction.Productive sporting performance in various sports disciplines often heavily depends on jumping abilities as well as on lower limb muscles power and endurance of the athletes involved. Both CrossFit, a popular high-intensity training program and sport climbing require lower extremity muscular power and endurance.

Published
2017
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47. Application of mesenchymal stem cells in paediatrics

Author

Wawryk-Gawda, Ewelina and Wojcik, Beata

Abstract

Mesenchymal stem cells (MSC) were described by Friedenstein in the 1970s as being a group of bone marrow non-hematopoietic cells that are the source of fibroblasts. Since then, knowledge about the therapeutic potential of MSCs has significantly increased. MSCs are currently used for the treatment of many diseases, both in adults and children. MSCs are used successfully in the case of autoimmune diseases, including rheumatic diseases, diabetes mellitus type 1, gastroenterological and neurological diseases. Moreover, treatment of such organ disorders as damage or hypoxia through application of MSC therapy has shown to be satisfactory. In addition, there are some types of congenital disorders, including osteogenesis imperfecta and Spinal Muscular Atrophy, that may be treated with cellular therapy. Most studies showed no other adverse effects than fever. Our study is an analysis that particularly focuses on the registered trials and results of MSCs application to under 18 patients with acute, chronic, recurrent, resistance and corticosteroids types of Graft-versus-Host Disease (GvHD). Stem cells currently play an important role in the treatment of many diseases. Long-term studies conducted on animals have shown that cell therapy is both effective and safe. The number of indications for use of these cells in the course of treatment of people is constantly increasing. The results of subsequent studies provide important data justifying the application of MSCs in the course of treatment of many diseases whose treatment is ineffective when utilizing other approaches.

Published
2017
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48. Autophagy in the pancreatic islets after the administration of cladribine in accordance to two different modes of therapy

Author

Jasinski, Ludwik, Lis-Sochocka, Marta, Chylinska-Wrzos, Patrycja, Wawryk-Gawda, Ewelina, and Jodlowska-Jedrych, Barbara

Abstract

The treatment of neoplastic and neurodegenerative diseases is still difficult. This because the cytostatic drugs have adverse effects on healthy organs. Among the drugs that have been investigated in the therapy of cancers and multiple sclerosis are the purine analogues. The aim of our study was the evaluation of the effect of cladribine on the process of autophagy in the healthy pancreas via two dosage models. The experiment was conducted on female Wistar rats which were placed within the experimental and control groups of two dosage models: model (A) - cladribine being administered in a daily dose of 0.1 mg/kg by weight for 7 days, and model (B) - cladribine being administered in a daily dose of 0.07 mg/kg by weight in 3 cycles of 6 days with 5 weeks break. A-bis and B-bis groups were included within, respectively, groups A and B. Here, decapitation occurred after 4 weeks break in drug administration. In our work, autophagy was investigated via the expression of the LC3B protein (Light Chain 3B protein). The comparison of the results of many independent trials was built upon the use of the Kruskal-Wallis non-parametric test. Significance was set at p < 0.005. In our results, average LC3B expression was observed in 100% of all cells in the group A, 70% in group B and 60% in group B-bis. We not observed average LC3B expression in the other groups. Moreover, a poor reaction was observed in 55% of all cells in group A-bis. We noted significant relationships between control group and group A, between the control group and group B, and between group A-bis and groups B and B-bis. These results demonstrate that cladribine has led to the induction of autophagy in the pancreatic islet cells.

Published
2017
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49. Prevalence of Personality Disorders in a General Population Among Men and Women

Author

Gawda, Barbara and Czubak, Katarzyna

Abstract

The aim of the present study is to establish the prevalence of personality disorders (PDs) in a healthy (nonclinical) Polish population, to examine sex difference in PDs, and to show the structure of clusters which PDs form with regard to men and women. A large sample of 1460 individuals of age between 18 and 65 years was examined. The Structured Clinical Interview for Axis II was used to obtain information on PDs, the Mini International Neuropsychiatric Interview to obtain information on other disorders, and an interview to record demographic data. Results show that approximately 9% of the sample had at least one PD (the overall rate is 8.9%) and rates on sex differences in PDs are similar to other European and North American countries. The most prevalent PDs are obsessive-compulsive (9.6%), narcissistic (7%), and borderline (7%). Results show the considerable comorbidity of PDs which means that about 9% of the adult population have at least one PD and in fact they display features of many specific PDs. A factor analysis revealed that 12 PDs form different clusters in men and women.

Published
2017
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50. A comparison of caspase 3 expression in the endocrine and exocrine parts of the pancreas after cladribine application according to the "leukemic" schema

Author

Jasinski, Ludwik, Chylinska-Wrzos, Patrycja, Lis-Sochocka, Marta, Wawryk-Gawda, Ewelina, and Jodlowska-Jedrych, Barbara

Abstract

The therapeutic effects of the immunosuppressive agent, cladribine, have been demonstrated by its toxicity to cells. However, its effects on healthy cells of the body is poorly understood. The aim of study was, hence, to, firstly, evaluate the morphology of the endocrine and exocrine pancreas after the administration of cladribine according to the "leukemic" schema, and, secondly, to assess its impact on the intensity of apoptosis. The experiment was carried out on female Wistar rats which were placed within the control group KA, and the experimental groups: A and A-bis. In the experimental groups, Cladribine was administered according to the cycle used to treat human hairy cell leukemia. In group A, the material was taken 24 hours after administration of the last dose of the drug, while in group A-bis, this was done after a 4 weeks break. The reaction was assessed to be average in 80% of all cells in group A, and in 64% of all acinar cells in group KA, while in group A-bis, the majority of the exocrine cells demonstrated a lack of immunohistochemical response (72%). Moreover, most endocrine cells (60%) in group A-bis revealed a strong reaction, while in Group A, the corresponding figure is a little over 34%. A comparison of the severity of the caspase 3 expression in both the exocrine and endocrine pancreas showed significant differentiation results between the group KA and group A-bis, and between group A and A-bis (p < 0.0001). In can be concluded that endocrine cells are more sensitive to cladribine than are exocrine cells.

Published
2017
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