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Background: The clinical management of ependymoma in childhood and adolescence is complex and the clinicobiopathological correlates of outcome remain poorly understood. This international SIOP Ependymoma II (SIOP EPII) trial aims to improve the outcome of patients with ependymoma. Methods: SIOP EPII includes any patient

Since the 1960s, Alvin Plantinga has focused on the problem of guaranteeing religious belief, de-fending the idea that a person does not transgress any epistemic rule by affirming that God exists and that no argument is necessary to be able to assert rationally that God exists.To support his thinking, he proposes a model. This model associates the Geneva reformer, John Calvin, to the Catholic theologian and philosopher, Thomas of Aquinas. Plantinga highlights their common reflections on the natural knowledge of God, an intuitive knowledge which, while not based on reasoning, is not considered contrary to reason. The following study seeks to test the re-levance of this Aquinas/Calvin model. Can the argument defended inWarranted Christian Belief indeed claim to be a development of ideas that sprouts from these two thinkers ?Plantinga's work is not the work of a Philosophy historian. The examination of his work requires first of all a good understanding of his model: understanding what problem it intends to solved and how this problem presented itself to the author. To the question: "Can or cannot the believer rationally affirm that God exists?" , theReformed Epistemology of which Plantinga is one of the initiators answer by developping an original way that intends to escape the traditional alternative between natural theology and natural atheology.Plantinga asserting that this way finds a rough outline in the religious epistemology of Aquinas and Calvin, the examination continues with a presentation of the conceptions that these two au-thors make of the natural knowledge of God. A philosophical model, if it is not an identical re-production of the original, must however resemble it. The study of Aquinas and Calvin aims to give a comprehensive idea of their apprehension of the question in order to be able to judge this resemblance.The study ends by confronting of the sources with the model. It begins by highlighting the com-mon features, showing that the author's intuition is not unfounded. But it then develops three themes: the link between original sin and the natural knowledge of God, thesensus divinitatis and the analogy with the sensitive, the confused knowledge and the distinct knowledge of God. And, these themes bear witness to a very different originality from that which the name of the model suggested., Depuis les années 1960, Alvin Plantinga s’est attaché au problème de la garantie de la croyance religieuse, défendant l’idée qu’une personne ne transgresse aucune règle épistémique en affirmant que Dieu existe et qu’aucune argumentation n’est nécessaire pour pouvoir affirmer rationnelle-ment que Dieu existe.Pour appuyer sa thèse, Plantinga propose un modèle. Ce modèle associe au réformateur de Ge-nève, Jean Calvin, le théologien et philosophe catholique, Thomas d’Aquin. Plantinga met en avant leurs réflexions communes sur la connaissance naturelle de Dieu, connaissance intuitive qui, bien que ne s’appuyant pas sur le raisonnement, n’est pas jugée contraire à la raison. L’étude qui suit cherche à éprouver la pertinence de ce modèle Aquinas/Calvin. La thèse défendue dansWarranted Christian Belief est-elle effectivement un développement d’idées déjà en germe chez ces deux penseurs ?L’œuvre de Plantinga n’étant pas une œuvre d’historien de la philosophie, l’examen de son travail requiert d’abord une bonne compréhension de son modèle : comprendre quel problème il entend résoudre et de quelle façon ce problème s’est présenté à l’auteur. À la question : « le croyant peut-il ou non affirmer rationnellement que Dieu existe ? », laReformed Epistemology dont Plan-tinga est l’un des initiateurs répond en développant une voie originale qui entend échapper à l’alternative traditionnelle entre théologie naturelle et athéologie.Plantinga affirmant que cette voie trouve un fondement dans l’épistémologie religieuse de Tho-mas et de Calvin, l’examen se poursuit par une présentation des conceptions que ces deux auteurs se font de la connaissance naturelle de Dieu. Un modèle philosophique, s’il n’est pas une repro-duction à l’identique de l’original, doit cependant lui ressembler. L’étude de Thomas et de Calvin vise à donner une idée exhaustive de leur appréhension de la question afin de pouvoir juger de cette ressemblance.L’étude se termine par une confrontation des sources au modèle. En en dégageant d’abord les traits communs, elle manifeste que l’intuition de l’auteur n’est pas sans fondement. Mais elle dé-veloppe ensuite trois thèmes : le lien entre le péché originel et la connaissance naturelle de Dieu, lesensus divinitatis et l’analogie avec le sensible, la connaissance confuse et la connaissance dis-tincte de Dieu, qui témoignent d’une originalité bien différente de celle que le nom du modèle laissait présager.

We reported two cases of Staphylococcus aureus Infective Endocarditis associated with vasculitides and glomerulonephritis respectively, before conducting an online search of previously published similar cases reports. Twenty five references were selected: 15 cases of glomerulonephritis; 2 cases of vasculitis and 8 cases involving both glomerulonephritis and vasculitis. Vasculitides and glomerulonephritis associated with Staphylococcus aureus definite Infective Endocarditis have been reported since 1976. All cases except one described clinical symptoms occurring before or during initial antibiotics treatment. Except kidney, organs that were more frequently affected by vasculitis process were skin, gastrointestinal tract and peripheral nerve and the vessels involved were small to medium size vessels. When antineutrophil cytoplasmic antibodies were evidenced (6 out of the 25 cases (24%)), kidney was the most frequently affected organ. The most commonly observed pattern in Kidney biopsy was membranoproliferative glomerulonephritis with endocapillary proliferation sometimes associated with extra capillary crescents, whether or not antineutrophil cytoplasmic antibodies were evidenced. Right-sided Infective Endocarditis (especially in intravenous drug users) were overrepresented (14 of the 25 cases (56.0%)) in this review. Besides antibiotics, corticosteroids were the most frequently prescribed immunosuppressive treatment both for vasculitides or glomerulonephritis. KEY MESSAGES Vasculitides and glomerulonephritis associated with Staphylococcus aureus definite Infective Endocarditis have been reported since 1976. Except kidney, organs that were more frequently affected (by small to medium size vessel vasculitis) were skin, gastrointestinal tract and peripheral nerve. The most commonly observed pattern in Kidney biopsy was membranoproliferative glomerulonephritis with endocapillary proliferation and right-sided Infective Endocarditis (especially in intravenous drug users) were overrepresented in this review.

Idelalisib is a potent and selective inhibitor of the PI3Kδ approved since September 2014 for the treatment of several types of B cell malignancies. Pulmonary adverse events related to idelalisib are an emerging serious adverse event. We report here a single centre cohort of 16 patients who initiated idelalisib as routine treatment. Five of them experienced severe pulmonary adverse events related to idelalisib therapy. Comparison of the 5 patients with severe pulmonary events versus the 11 patients without identified no predisposing factors. Severe pulmonary adverse events were related to infectious pneumonia and/or to a drug-induced pneumonitis. The mechanisms of idelalisib-associated pneumonitis are unknown but consistent with the drug-induced pneumonitis described with mTOR inhibitors. Indeed, by inhibiting PI3Kδ, idelalisib also inhibits the mTOR pathway. Clinicians should be aware that any idelalisib-treated patient who presents with pulmonary symptoms should be evaluated for pneumonitis. Corticosteroids should be considered in addition to anti-infective therapy in case of severe pneumonitis or persistent pulmonary symptoms despite adequate antibiotic therapy.

Laser plasma acceleration (LPA) with up to several GeV beam in very short distance appears very promising. The Free Electron Laser (FEL), though very challenging, can be viewed as a qualifying application of these new emerging LPAs. The energy spread and divergence, larger than from conventional accelerators used for FEL, have to be manipulated to fulfil the FEL requirements. On the test experiment COXINEL (ERC340015), the beam is controlled in a manipulation [1,2] line, using permanent magnet quadrupoles of variable strength [3] for emittance handing and a decompression chicane equipped with a slit for the energy selection, enabling FEL amplification for baseline reference parameters [2]. The electron position and dispersion are independently adjusted [4]. The measured spontaneous emission radiated by a 2 m long 18 mm period cryo-ready undulator exhibits the typical undulator spatio-spectral pattern, in agreement with the modelling of the electron beam travelling along the line and of the afferent photon generation. The wavelength is easily tuned with undulator gap variation. A wavelength stability of 2.6% is achieved. The undulator linewidth can be controlled., Proceedings of the 39th Free Electron Laser Conference, FEL2019, Hamburg, Germany

The recent spectacular development of laser plasma ac- celerators that now can deliver GeV electron beams in an extremelyshortdistancemakesthemverypromising. Ap- plications for light sources based on undulator radiation and free electron laser appear as an intermediate step to move from an acceleration concept to an accelerator qual- ification. However, the presently achieved divergence and energy spread require some electron beam manipulations. The COXINEL test line was designed for enabling Free Elec- tron Laser operation with baseline reference parameters. It comprises variable permanent magnet quadrupoles for di- vergence handling, a magnetic chicane for electron energy sorting, a second set of quadrupole for chromatic focusing and an undulator for synchrotron radiation emission and/or free electron laser gain medium. The transport along the line is controlled [1]. The synchrotron radiation emitted by the undulator radiation is studied under different conditions of detection (CCD camera, spectrometer), electron beam manipulation and undulator parameters. These observations pave the way towards Laser Plasma Acceleration based Free Electron Laser., Proceedings of the 10th Int. Particle Accelerator Conf., IPAC2019, Melbourne, Australia

The ERC Advanced Grant COXINEL aims at demonstrating free electron laser amplification, at a resonant wavelength of 200 nm, based on a laser plasma acceleration source. To achieve the amplification, a 10 m long dedicated transport line was designed to manipulate the beam qualities. It starts with a triplet of permanent magnet with tunable gradient quadrupoles (QUAPEVA) that handles the highly divergent electron beam, a demixing chicane with a slit to reduce the energy spread per slice, and a set of electromagnetic quadrupoles to provide a chromatic focusing in a 2 m long cryogenic undulator. Electrons of energy 176 MeV were successfully transported throughout the line, where the beam positioning and dispersion were controlled efficiently thanks to a specific beam based alignment method, as well as the energy range by varying the slit width. Observations of undulator radiation for different undulator gaps are reported., Proceedings of the 60th ICFA Advanced Beam Dynamics Workshop on Future Light Sources, FLS2018, Shanghai, China

Since the laser invention, the advent of X-ray Free Electron Lasers (FEL) half a century later, opens new areas for matter investigation. In parallel, the spectacular development of laser plasma acceleration (LPA) with several GeV beam acceleration in an extremely short distance appears very promising. As a first step, the qualification of the LPA with a FEL application sets a first challenge. Still, energy spread and beam divergence do not meet the state-of-the-art performance of the conventional accelerators and have to be manipulated to fulfill the FEL requirement. We report here on the undulator spontaneous emission measured after a transport manipulation electron beam line, using variable permanent magnet quadrupoles of variable strength for emittance handing and a demixing chicane equipped with a slit for the energy spread. Strategies of control electron beam position and dispersion have been elaborated. The measured undulator radiation provides an insight on the electron beam properties., Proceedings of the 9th Int. Particle Accelerator Conf., IPAC2018, Vancouver, BC, Canada