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3,086 results on '"Gauthier, Serge"'

2. Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease

Author

Aguzzoli, Cristiano Schaffer, Ferreira, Pâmela CL, Povala, Guilherme, Ferrari-Souza, João Pedro, Bellaver, Bruna, Katz, Carolina Soares, Zalzale, Hussein, Lussier, Firoza Z, Rohden, Francieli, Abbas, Sarah, Leffa, Douglas T, Medeiros, Marina Scop, Therriault, Joseph, Benedet, Andréa L, Tissot, Cécile, Servaes, Stijn, Rahmouni, Nesrine, Macedo, Arthur Cassa, Bezgin, Gleb, Kang, Min Su, Stevenson, Jenna, Pallen, Vanessa, Cohen, Ann, Lopez, Oscar L, Tudorascu, Dana L, Klunk, William E, Villemagne, Victor L, Soucy, Jean Paul, Zimmer, Eduardo R, Schilling, Lucas P, Karikari, Thomas K, Ashton, Nicholas J, Zetterberg, Henrik, Blennow, Kaj, Gauthier, Serge, Valcour, Victor, Miller, Bruce L, Rosa-Neto, Pedro, and Pascoal, Tharick A

Subjects
Health Services and Systems, Health Sciences, Aging, Alzheimer's Disease, Brain Disorders, Acquired Cognitive Impairment, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurosciences, Biomedical Imaging, Neurodegenerative, Clinical Research, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Neurological, Male, Humans, Female, Aged, Alzheimer Disease, Microglia, tau Proteins, Cross-Sectional Studies, Amyloid beta-Peptides, Biomarkers, Biomedical and clinical sciences, Health sciences
Abstract

ImportanceNeuropsychiatric symptoms are commonly encountered and are highly debilitating in patients with Alzheimer disease. Understanding their underpinnings has implications for identifying biomarkers and treatment for these symptoms.ObjectiveTo evaluate whether glial markers are associated with neuropsychiatric symptoms in individuals across the Alzheimer disease continuum.Design, setting, and participantsThis cross-sectional study was conducted from January to June 2023, leveraging data from the Translational Biomarkers in Aging and Dementia cohort at McGill University, Canada. Recruitment was based on referrals of individuals from the community or from outpatient clinics. Exclusion criteria included active substance abuse, major surgery, recent head trauma, safety contraindications for positron emission tomography (PET) or magnetic resonance imaging, being currently enrolled in other studies, and having inadequately treated systemic conditions.Main outcomes and measuresAll individuals underwent assessment for neuropsychiatric symptoms (Neuropsychiatry Inventory Questionnaire [NPI-Q]), and imaging for microglial activation ([11C]PBR28 PET), amyloid-β ([18F]AZD4694 PET), and tau tangles ([18F]MK6240 PET).ResultsOf the 109 participants, 72 (66%) were women and 37 (34%) were men; the median age was 71.8 years (range, 38.0-86.5 years). Overall, 70 had no cognitive impairment and 39 had cognitive impairment (25 mild; 14 Alzheimer disease dementia). Amyloid-β PET positivity was present in 21 cognitively unimpaired individuals (30%) and in 31 cognitively impaired individuals (79%). The NPI-Q severity score was associated with microglial activation in the frontal, temporal, and parietal cortices (β = 7.37; 95% CI, 1.34-13.41; P = .01). A leave-one-out approach revealed that irritability was the NPI-Q domain most closely associated with the presence of brain microglial activation (β = 6.86; 95% CI, 1.77-11.95; P = .008). Furthermore, we found that microglia-associated irritability was associated with study partner burden measured by NPI-Q distress score (β = 5.72; 95% CI, 0.33-11.10; P = .03).Conclusions and relevanceIn this cross-sectional study of 109 individuals across the AD continuum, microglial activation was associated with and a potential biomarker of neuropsychiatric symptoms in Alzheimer disease. Moreover, our findings suggest that the combination of amyloid-β- and microglia-targeted therapies could have an impact on relieving these symptoms.

Published
2023

3. Hormone therapy is associated with lower Alzheimer’s disease tau biomarkers in post-menopausal females -evidence from two independent cohorts

Author

Wang, Yi-Ting, Therriault, Joseph, Tissot, Cécile, Servaes, Stijn, Rahmouni, Nesrine, Macedo, Arthur Cassa, Fernandez-Arias, Jaime, Mathotaarachchi, Sulantha S., Stevenson, Jenna, Lussier, Firoza Z., Benedet, Andréa L., Pascoal, Tharick A., Ashton, Nicholas J., Zetterberg, Henrik, Blennow, Kaj, Gauthier, Serge, and Rosa-Neto, Pedro

Published
2024
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4. Tau follows principal axes of functional and structural brain organization in Alzheimer’s disease

Author

Ottoy, Julie, Kang, Min Su, Tan, Jazlynn Xiu Min, Boone, Lyndon, Vos de Wael, Reinder, Park, Bo-yong, Bezgin, Gleb, Lussier, Firoza Z., Pascoal, Tharick A., Rahmouni, Nesrine, Stevenson, Jenna, Fernandez Arias, Jaime, Therriault, Joseph, Hong, Seok-Jun, Stefanovic, Bojana, McLaurin, JoAnne, Soucy, Jean-Paul, Gauthier, Serge, Bernhardt, Boris C., Black, Sandra E., Rosa-Neto, Pedro, and Goubran, Maged

Published
2024
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6. Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology

Author

Therriault, Joseph, Woo, Marcel S., Salvadó, Gemma, Gobom, Johan, Karikari, Thomas K., Janelidze, Shorena, Servaes, Stijn, Rahmouni, Nesrine, Tissot, Cécile, Ashton, Nicholas J., Benedet, Andréa Lessa, Montoliu-Gaya, Laia, Macedo, Arthur C., Lussier, Firoza Z., Stevenson, Jenna, Vitali, Paolo, Friese, Manuel A., Massarweh, Gassan, Soucy, Jean-Paul, Pascoal, Tharick A., Stomrud, Erik, Palmqvist, Sebastian, Mattsson-Carlgren, Niklas, Gauthier, Serge, Zetterberg, Henrik, Hansson, Oskar, Blennow, Kaj, and Rosa-Neto, Pedro

Published
2024
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7. Biomarker-based staging of Alzheimer disease: rationale and clinical applications

Author

Therriault, Joseph, Schindler, Suzanne E., Salvadó, Gemma, Pascoal, Tharick A., Benedet, Andréa Lessa, Ashton, Nicholas J., Karikari, Thomas K., Apostolova, Liana, Murray, Melissa E., Verberk, Inge, Vogel, Jacob W., La Joie, Renaud, Gauthier, Serge, Teunissen, Charlotte, Rabinovici, Gil D., Zetterberg, Henrik, Bateman, Randall J., Scheltens, Philip, Blennow, Kaj, Sperling, Reisa, Hansson, Oskar, Jack, Jr, Clifford R., and Rosa-Neto, Pedro

Published
2024
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8. APOEε4 potentiates amyloid β effects on longitudinal tau pathology

Author

Ferrari-Souza, João Pedro, Bellaver, Bruna, Ferreira, Pâmela C. L., Benedet, Andréa L., Povala, Guilherme, Lussier, Firoza Z., Leffa, Douglas T., Therriault, Joseph, Tissot, Cécile, Soares, Carolina, Wang, Yi-Ting, Chamoun, Mira, Servaes, Stijn, Macedo, Arthur C., Vermeiren, Marie, Bezgin, Gleb, Kang, Min Su, Stevenson, Jenna, Rahmouni, Nesrine, Pallen, Vanessa, Poltronetti, Nina Margherita, Cohen, Ann, Lopez, Oscar L., Klunk, William E., Soucy, Jean-Paul, Gauthier, Serge, Souza, Diogo O., Triana-Baltzer, Gallen, Saad, Ziad S., Kolb, Hartmuth C., Karikari, Thomas K., Villemagne, Victor L., Tudorascu, Dana L., Ashton, Nicholas J., Zetterberg, Henrik, Blennow, Kaj, Zimmer, Eduardo R., Rosa-Neto, Pedro, and Pascoal, Tharick A.

Published
2023
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9. Prediction of cognitive decline for enrichment of Alzheimer's disease clinical trials

Author

Tam, Angela, Laurent, César, Gauthier, Serge, and Dansereau, Christian

Subjects
Quantitative Biology - Quantitative Methods
Abstract

A key issue to Alzheimer's disease clinical trial failures is poor participant selection. Participants have heterogeneous cognitive trajectories and many do not decline during trials, which reduces a study's power to detect treatment effects. Trials need enrichment strategies to enroll individuals who will decline. We developed machine learning models to predict cognitive trajectories in participants with early Alzheimer's disease (n=1342) and presymptomatic individuals (n=756) over 24 and 48 months respectively. Baseline magnetic resonance imaging, cognitive tests, demographics, and APOE genotype were used to classify decliners, measured by an increase in CDR-Sum of Boxes, and non-decliners with up to 79% area under the curve (cross-validated and out-of-sample). Using these prognostic models to recruit enriched cohorts of decliners can reduce required sample sizes by as much as 51%, while maintaining the same detection power, and thus may improve trial quality, derisk endpoint failures, and accelerate therapeutic development in Alzheimer's disease., Comment: 11 pages, 3 main figures, 3 main tables, supplementary material (3 tables, 2 figures), incorporated feedback from reviewers in the introduction and discussion

Published
2021
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10. Modeling the progression of neuropsychiatric symptoms in Alzheimer’s disease with PET-based Braak staging

Author

Macedo, Arthur C., Therriault, Joseph, Tissot, Cécile, Aumont, Étienne, Servaes, Stijn, Rahmouni, Nesrine, Fernandez-Arias, Jaime, Lussier, Firoza Z., Wang, Yi-Ting, Ng, Kok Pin, Vermeiren, Marie, Bezgin, Gleb, Socualaya, Kely Quispialaya, Stevenson, Jenna, Hosseini, Seyyed Ali, Chamoun, Mira, Ferrari-Souza, João Pedro, Ferreira, Pâmela C.L., Bellaver, Bruna, Leffa, Douglas Teixeira, Vitali, Paolo, Zimmer, Eduardo R., Ismail, Zahinoor, Pascoal, Tharick A., Gauthier, Serge, and Rosa-Neto, Pedro

Published
2024
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11. The neurophysiological brain-fingerprint of Parkinson’s disease

Author

Breitner, John, Poirier, Judes, Baillet, Sylvain, Bellec, Pierre, Bohbot, Véronique, Chakravarty, Mallar, Collins, Louis, Etienne, Pierre, Evans, Alan, Gauthier, Serge, Hoge, Rick, Ituria-Medina, Yasser, Multhaup, Gerhard, Münter, Lisa-Marie, Rajah, Natasha, Rosa-Neto, Pedro, Soucy, Jean-Paul, Vachon-Presseau, Etienne, Villeneuve, Sylvia, Amouyel, Philippe, Appleby, Melissa, Ashton, Nicholas, Auld, Daniel, Ayranci, Gülebru, Bedetti, Christophe, Beland, Marie-Lise, Blennow, Kaj, Westman, Ann Brinkmalm, Cuello, Claudio, Dadar, Mahsa, Daoust, Leslie-Ann, Das, Samir, Dauar-Tedeschi, Marina, De Beaumont, Louis, Dea, Doris, Descoteaux, Maxime, Dufour, Marianne, Farzin, Sarah, Ferdinand, Fabiola, Fonov, Vladimir, Gonneaud, Julie, Kat, Justin, Kazazian, Christina, Labonté, Anne, Lafaille-Magnan, Marie-Elyse, Lalancette, Marc, Lambert, Jean-Charles, Leoutsakos, Jeannie-Marie, Mahar, Laura, Mathieu, Axel, McSweeney, Melissa, Meyer, Pierre-François, Miron, Justin, Near, Jamie, NewboldFox, Holly, Nilsson, Nathalie, Orban, Pierre, Picard, Cynthia, Binette, Alexa Pichet, Poline, Jean-Baptiste, Rabipour, Sheida, Salaciak, Alyssa, Settimi, Matthew, Subramaniapillai, Sivaniya, Tam, Angela, Tardif, Christine, Théroux, Louise, Tremblay-Mercier, Jennifer, Tullo, Stephanie, Ulku, Irem, Vallée, Isabelle, Zetterberg, Henrik, Nair, Vasavan, Pruessner, Jens, Aisen, Paul, Anthal, Elena, Barkun, Alan, Beaudry, Thomas, Benbouhoud, Fatiha, Brandt, Jason, Carmo, Leopoldina, Carrier, Charles Edouard, Cheewakriengkrai, Laksanun, Courcot, Blandine, Couture, Doris, Craft, Suzanne, Dansereau, Christian, Debacker, Clément, Desautels, René, Dubuc, Sylvie, Duclair, Guerda, Eisenberg, Mark, El-Khoury, Rana, Faubert, Anne-Marie, Fontaine, David, Frappier, Josée, Frenette, Joanne, Gagné, Guylaine, Gervais, Valérie, Giles, Renuka, Gordon, Renee, Jack, Clifford, Jutras, Benoit, Khachaturian, Zaven, Knopman, David, Kostopoulos, Penelope, Lapalme, Félix, Lee, Tanya, Lepage, Claude, Leppert, Illana, Madjar, Cécile, Maillet, David, Maltais, Jean-Robert, Mathotaarachchi, Sulantha, Mayrand, Ginette, Michaud, Diane, Montine, Thomas, Morris, John, Pagé, Véronique, Pascoal, Tharick, Peillieux, Sandra, Petkova, Mirela, Pogossova, Galina, Rioux, Pierre, Sager, Mark, Saint-Fort, Eunice Farah, Savard, Mélissa, Sperling, Reisa, Tabrizi, Shirin, Tariot, Pierre, Teigner, Eduard, Thomas, Ronald, Toussaint, Paule-Joanne, Tuwaig, Miranda, Venugopalan, Vinod, Verfaillie, Sander, Vogel, Jacob, Wan, Karen, Wang, Seqian, Yu, Elsa, Beaulieu-Boire, Isabelle, Blanchet, Pierre, Bogard, Sarah, Bouchard, Manon, Chouinard, Sylvain, Cicchetti, Francesca, Cloutier, Martin, Dagher, Alain, Degroot, Clotilde, Desautels, Alex, Dion, Marie Hélène, Drouin-Ouellet, Janelle, Dufresne, Anne-Marie, Dupré, Nicolas, Duquette, Antoine, Durcan, Thomas, Fellows, Lesley K., Fon, Edward, Gagnon, Jean-François, Gan-Or, Ziv, Genge, Angela, Jodoin, Nicolas, Karamchandani, Jason, Lafontaine, Anne-Louise, Langlois, Mélanie, Leveille, Etienne, Lévesque, Martin, Melmed, Calvin, Monchi, Oury, Montplaisir, Jacques, Panisset, Michel, Parent, Martin, Pham-An, Minh-Thy, Postuma, Ronald, Pourcher, Emmanuelle, Rao, Trisha, Rivest, Jean, Rouleau, Guy, Sharp, Madeleine, Soland, Valérie, Sidel, Michael, Wing Sun, Sonia Lai, Thiel, Alexander, Vitali, Paolo, da Silva Castanheira, Jason, Wiesman, Alex I., Hansen, Justine Y., and Misic, Bratislav

Published
2024
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12. 14-3-3 ζ/δ-reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2

Author

Woo, Marcel S., Nilsson, Johanna, Therriault, Joseph, Rahmouni, Nesrine, Brinkmalm, Ann, Benedet, Andrea L., Ashton, Nicholas J., Macedo, Arthur C., Servaes, Stijn, Wang, Yi-Ting, Tissot, Cécile, Arias, Jaime Fernandez, Hosseini, Seyyed Ali, Chamoun, Mira, Lussier, Firoza Z., Karikari, Thomas K., Stevenson, Jenna, Mayer, Christina, Ferrari-Souza, João Pedro, Kobayashi, Eliane, Massarweh, Gassan, Friese, Manuel A., Pascoal, Tharick A., Gauthier, Serge, Zetterberg, Henrik, Blennow, Kaj, and Rosa-Neto, Pedro

Published
2023
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14. Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease

Author

Bellaver, Bruna, Povala, Guilherme, Ferreira, Pamela C. L., Ferrari-Souza, João Pedro, Leffa, Douglas T., Lussier, Firoza Z., Benedet, Andréa L., Ashton, Nicholas J., Triana-Baltzer, Gallen, Kolb, Hartmuth C., Tissot, Cécile, Therriault, Joseph, Servaes, Stijn, Stevenson, Jenna, Rahmouni, Nesrine, Lopez, Oscar L., Tudorascu, Dana L., Villemagne, Victor L., Ikonomovic, Milos D., Gauthier, Serge, Zimmer, Eduardo R., Zetterberg, Henrik, Blennow, Kaj, Aizenstein, Howard J., Klunk, William E., Snitz, Beth E., Maki, Pauline, Thurston, Rebecca C., Cohen, Ann D., Ganguli, Mary, Karikari, Thomas K., Rosa-Neto, Pedro, and Pascoal, Tharick A.

Published
2023
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15. Longitudinal head-to-head comparison of 11C-PiB and 18F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly inherited Alzheimer’s disease

Author

Chen, Charles D., McCullough, Austin, Gordon, Brian, Joseph-Mathurin, Nelly, Flores, Shaney, McKay, Nicole S., Hobbs, Diana A., Hornbeck, Russ, Fagan, Anne M., Cruchaga, Carlos, Goate, Alison M., Perrin, Richard J., Wang, Guoqiao, Li, Yan, Shi, Xinyu, Xiong, Chengjie, Pontecorvo, Michael J., Klein, Gregory, Su, Yi, Klunk, William E., Jack, Clifford, Koeppe, Robert, Snider, B. Joy, Berman, Sarah B., Roberson, Erik D., Brosch, Jared, Surti, Ghulam, Jiménez-Velázquez, Ivonne Z., Galasko, Douglas, Honig, Lawrence S., Brooks, William S., Clarnette, Roger, Wallon, David, Dubois, Bruno, Pariente, Jérémie, Pasquier, Florence, Sanchez-Valle, Raquel, Shcherbinin, Sergey, Higgins, Ixavier, Tunali, Ilke, Masters, Colin L., van Dyck, Christopher H., Masellis, Mario, Hsiung, Robin, Gauthier, Serge, Salloway, Steve, Clifford, David B., Mills, Susan, Supnet-Bell, Charlene, McDade, Eric, Bateman, Randall J., and Benzinger, Tammie L. S.

Published
2023
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17. Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Author

Gonneaud, Julie, Baria, Alex T, Pichet Binette, Alexa, Gordon, Brian A, Chhatwal, Jasmeer P, Cruchaga, Carlos, Jucker, Mathias, Levin, Johannes, Salloway, Stephen, Farlow, Martin, Gauthier, Serge, Benzinger, Tammie LS, Morris, John C, Bateman, Randall J, Breitner, John CS, Poirier, Judes, Vachon-Presseau, Etienne, and Villeneuve, Sylvia

Subjects
Biological Psychology, Psychology, Clinical Research, Neurodegenerative, Aging, Brain Disorders, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Acquired Cognitive Impairment, Alzheimer's Disease, Dementia, Neurological, Adult, Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Brain, Brain Mapping, Cognitive Dysfunction, Female, Genetic Predisposition to Disease, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Mutation, Positron-Emission Tomography, Young Adult, Alzheimer’s Disease Neuroimaging Initiative, Dominantly Inherited Alzheimer Network (DIAN) Study Group, Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group
Abstract

Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer's disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (Aβ) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18-94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the context of pre-clinical AD revealed that the pre-symptomatic phase of autosomal dominant AD includes acceleration of functional brain aging. This association was stronger in individuals having significant Aβ pathology.

Published
2021

18. Prodromal language impairment in genetic frontotemporal dementia within the GENFI cohort

Author

Nelson, Annabel, Thomas, David L., Todd, Emily, Benotmane, Hanya, Nicholas, Jennifer, Shafei, Rachelle, Timberlake, Carolyn, Cope, Thomas, Rittman, Timothy, Benussi, Alberto, Premi, Enrico, Gasparotti, Roberto, Archetti, Silvana, Gazzina, Stefano, Cantoni, Valentina, Arighi, Andrea, Fenoglio, Chiara, Scarpini, Elio, Fumagalli, Giorgio, Borracci, Vittoria, Rossi, Giacomina, Giaccone, Giorgio, Di Fede, Giuseppe, Caroppo, Paola, Prioni, Sara, Redaelli, Veronica, Tang-Wai, David, Rogaeva, Ekaterina, Castelo-Branco, Miguel, Freedman, Morris, Keren, Ron, Black, Sandra, Mitchell, Sara, Shoesmith, Christen, Bartha, Robart, Rademakers, Rosa, Poos, Jackie, Papma, Janne M., Giannini, Lucia, van Minkelen, Rick, Pijnenburg, Yolande, Nacmias, Benedetta, Ferrari, Camilla, Polito, Cristina, Lombardi, Gemma, Bessi, Valentina, Veldsman, Michele, Andersson, Christin, Thonberg, Hakan, Öijerstedt, Linn, Jelic, Vesna, Thompson, Paul, Langheinrich, Tobias, Lladó, Albert, Antonell, Anna, Olives, Jaume, Balasa, Mircea, Bargalló, Nuria, Borrego-Ecija, Sergi, Verdelho, Ana, Maruta, Carolina, Ferreira, Catarina B., Miltenberger, Gabriel, do Couto, Frederico Simões, Gabilondo, Alazne, Gorostidi, Ana, Villanua, Jorge, Cañada, Marta, Tainta, Mikel, Zulaica, Miren, Barandiaran, Myriam, Alves, Patricia, Bender, Benjamin, Wilke, Carlo, Graf, Lisa, Vogels, Annick, Vandenbulcke, Mathieu, Van Damme, Philip, Bruffaerts, Rose, Poesen, Koen, Rosa-Neto, Pedro, Gauthier, Serge, Camuzat, Agnès, Brice, Alexis, Bertrand, Anne, Funkiewiez, Aurélie, Rinaldi, Daisy, Saracino, Dario, Colliot, Olivier, Sayah, Sabrina, Prix, Catharina, Wlasich, Elisabeth, Wagemann, Olivia, Loosli, Sandra, Schönecker, Sonja, Hoegen, Tobias, Lombardi, Jolina, Anderl-Straub, Sarah, Rollin, Adeline, Kuchcinski, Gregory, Bertoux, Maxime, Lebouvier, Thibaud, Deramecourt, Vincent, Santiago, Beatriz, Duro, Diana, Leitão, Maria João, Almeida, Maria Rosario, Tábuas-Pereira, Miguel, Afonso, Sónia, Samra, Kiran, MacDougall, Amy M., Bouzigues, Arabella, Bocchetta, Martina, Cash, David M., Greaves, Caroline V., Convery, Rhian S., van Swieten, John C., Jiskoot, Lize, Seelaar, Harro, Moreno, Fermin, Sanchez-Valle, Raquel, Laforce, Robert, Graff, Caroline, Masellis, Mario, Tartaglia, Maria Carmela, Rowe, James B., Borroni, Barbara, Finger, Elizabeth, Synofzik, Matthis, Galimberti, Daniela, Vandenberghe, Rik, de Mendonça, Alexandre, Butler, Chris R., Gerhard, Alex, Ducharme, Simon, Le Ber, Isabelle, Tiraboschi, Pietro, Santana, Isabel, Pasquier, Florence, Levin, Johannes, Otto, Markus, Sorbi, Sandro, Rohrer, Jonathan D., and Russell, Lucy L.

Published
2023
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19. Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease

Author

Ferrari-Souza, João Pedro, Ferreira, Pâmela C. L., Bellaver, Bruna, Tissot, Cécile, Wang, Yi-Ting, Leffa, Douglas T., Brum, Wagner S., Benedet, Andréa L., Ashton, Nicholas J., De Bastiani, Marco Antônio, Rocha, Andréia, Therriault, Joseph, Lussier, Firoza Z., Chamoun, Mira, Servaes, Stijn, Bezgin, Gleb, Kang, Min Su, Stevenson, Jenna, Rahmouni, Nesrine, Pallen, Vanessa, Poltronetti, Nina Margherita, Klunk, William E., Tudorascu, Dana L., Cohen, Ann D., Villemagne, Victor L., Gauthier, Serge, Blennow, Kaj, Zetterberg, Henrik, Souza, Diogo O., Karikari, Thomas K., Zimmer, Eduardo R., Rosa-Neto, Pedro, and Pascoal, Tharick A.

Published
2022
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21. Agitation and impulsivity in mid and late life as possible risk markers for incident dementia.

Author

Bateman, Daniel, Gill, Sascha, Hu, Sophie, Foster, Erin, Ruthirakuhan, Myuri, Sellek, Allis, Mortby, Moyra, Matušková, Veronika, Ng, Kok, Tarawneh, Rawan, Freund-Levi, Yvonne, Kumar, Sanjeev, Gauthier, Serge, Rosenberg, Paul, Ferreira de Oliveira, Fabricio, Devanand, D, Ballard, Clive, and Ismail, Zahinoor

Subjects
MBI, agitation, disinhibition, impulse dyscontrol, impulsivity, mild behavioral impairment, pre‐dementia
Abstract

To identify knowledge gaps regarding new-onset agitation and impulsivity prior to onset of cognitive impairment or dementia the International Society to Advance Alzheimers Research and Treatment Neuropsychiatric Syndromes (NPS) Professional Interest Area conducted a scoping review. Extending a series of reviews exploring the pre-dementia risk syndrome Mild Behavioral Impairment (MBI), we focused on late-onset agitation and impulsivity (the MBI impulse dyscontrol domain) and risk of incident cognitive decline and dementia. This scoping review of agitation and impulsivity pre-dementia syndromes summarizes the current biomedical literature in terms of epidemiology, diagnosis and measurement, neurobiology, neuroimaging, biomarkers, course and prognosis, treatment, and ongoing clinical trials. Validations for pre-dementia scales such as the MBI Checklist, and incorporation into longitudinal and intervention trials, are needed to better understand impulse dyscontrol as a risk factor for mild cognitive impairment and dementia.

Published
2020

22. Non-Amyloid Approaches to Disease Modification for Alzheimer’s Disease: An EU/US CTAD Task Force Report

Author

Gauthier, Serge, Aisen, PS, Cummings, J, Detke, MJ, Longo, FM, Raman, R, Sabbagh, M, Schneider, L, Tanzi, R, Tariot, P, Weiner, M, Touchon, J, and Vellas, B

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Cognitive and Computational Psychology, Neurosciences, Psychology, Brain Disorders, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, Aging, Alzheimer's Disease, Acquired Cognitive Impairment, Neurodegenerative, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Neurological, Alzheimer's disease, dementia, tau, tauopathy, neurotrophins, neuroinflammation, lifestyle intervention, photobiomodulation, neurostimulation, geroscience, EU/US CTAD Task Force, Alzheimer’s disease, Biological psychology, Cognitive and computational psychology
Abstract

While amyloid-targeting therapies continue to predominate in the Alzheimer's disease (AD) drug development pipeline, there is increasing recognition that to effectively treat the disease it may be necessary to target other mechanisms and pathways as well. In December 2019, The EU/US CTAD Task Force discussed these alternative approaches to disease modification in AD, focusing on tau-targeting therapies, neurotrophin receptor modulation, anti-microbial strategies, and the innate immune response; as well as vascular approaches, aging, and non-pharmacological approaches such as lifestyle intervention strategies, photobiomodulation and neurostimulation. The Task Force proposed a general strategy to accelerate the development of alternative treatment approaches, which would include increased partnerships and collaborations, improved trial designs, and further exploration of combination therapy strategies.

Published
2020

23. Frontotemporal dementia and COVID‐19: Hypothesis generation and roadmap for future research

Author

Ng, Kok Pin, Chiew, Hui Jin, Hameed, Shahul, Ting, Simon Kang Seng, Ng, Adeline, Soo, See Ann, Wong, Benjamin YX, Lim, Levinia, Yong, Alisa CW, Mok, Vincent CT, Rosa‐Neto, Pedro, Dominguez, Jacqueline, Kim, SangYun, Hsiung, GY Robin, Ikeda, Manabu, Miller, Bruce L, Gauthier, Serge, and Kandiah, Nagaendran

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Clinical Research, Neurodegenerative, Rare Diseases, Frontotemporal Dementia (FTD), Acquired Cognitive Impairment, Behavioral and Social Science, Aging, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Dementia, Alzheimer's Disease, Neurological, COVID-19, frontotemporal dementia, research roadmap, COVID‐19, Clinical sciences, Biological psychology
Abstract

The COVID-19 pandemic has caused tremendous suffering for patients with dementia and their caregivers. We conducted a survey to study the impact of the pandemic on patients with mild frontotemporal dementia (FTD). Our preliminary findings demonstrate that patients with FTD have significant worsening in behavior and social cognition, as well as suffer greater negative consequences from disruption to health-care services compared to patients with AD. The reduced ability to cope with sudden changes to social environments places patients with FTD at increased vulnerability to COVID-19 infection as well as to poorer clinical and social outcomes. Caregivers of FTD patients also demonstrate high burden during crisis situations. A proportion of patients with FTD benefitted from use of web-based interactive platforms. In this article, we outline the priority areas for research as well as a roadmap for future collaborative research to ensure greatest benefit for patients with FTD and their caregivers.

Published
2020

24. Comparison of Pittsburgh compound B and florbetapir in cross‐sectional and longitudinal studies

Author

Su, Yi, Flores, Shaney, Wang, Guoqiao, Hornbeck, Russ C, Speidel, Benjamin, Joseph‐Mathurin, Nelly, Vlassenko, Andrei G, Gordon, Brian A, Koeppe, Robert A, Klunk, William E, Jack, Clifford R, Farlow, Martin R, Salloway, Stephen, Snider, Barbara J, Berman, Sarah B, Roberson, Erik D, Brosch, Jared, Jimenez‐Velazques, Ivonne, Dyck, Christopher H, Galasko, Douglas, Yuan, Shauna H, Jayadev, Suman, Honig, Lawrence S, Gauthier, Serge, Hsiung, Ging‐Yuek R, Masellis, Mario, Brooks, William S, Fulham, Michael, Clarnette, Roger, Masters, Colin L, Wallon, David, Hannequin, Didier, Dubois, Bruno, Pariente, Jeremie, Sanchez‐Valle, Raquel, Mummery, Catherine, Ringman, John M, Bottlaender, Michel, Klein, Gregory, Milosavljevic‐Ristic, Smiljana, McDade, Eric, Xiong, Chengjie, Morris, John C, Bateman, Randall J, and Benzinger, Tammie LS

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Bioengineering, Aging, Alzheimer's Disease, Clinical Research, Brain Disorders, Neurodegenerative, Dementia, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Biomedical Imaging, Neurosciences, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, PiB, Florbetapir, Amyloid imaging, Centiloid, Positron emission tomography, Genetics, Biological psychology
Abstract

IntroductionQuantitative in vivo measurement of brain amyloid burden is important for both research and clinical purposes. However, the existence of multiple imaging tracers presents challenges to the interpretation of such measurements. This study presents a direct comparison of Pittsburgh compound B-based and florbetapir-based amyloid imaging in the same participants from two independent cohorts using a crossover design.MethodsPittsburgh compound B and florbetapir amyloid PET imaging data from three different cohorts were analyzed using previously established pipelines to obtain global amyloid burden measurements. These measurements were converted to the Centiloid scale to allow fair comparison between the two tracers. The mean and inter-individual variability of the two tracers were compared using multivariate linear models both cross-sectionally and longitudinally.ResultsGlobal amyloid burden measured using the two tracers were strongly correlated in both cohorts. However, higher variability was observed when florbetapir was used as the imaging tracer. The variability may be partially caused by white matter signal as partial volume correction reduces the variability and improves the correlations between the two tracers. Amyloid burden measured using both tracers was found to be in association with clinical and psychometric measurements. Longitudinal comparison of the two tracers was also performed in similar but separate cohorts whose baseline amyloid load was considered elevated (i.e., amyloid positive). No significant difference was detected in the average annualized rate of change measurements made with these two tracers.DiscussionAlthough the amyloid burden measurements were quite similar using these two tracers as expected, difference was observable even after conversion into the Centiloid scale. Further investigation is warranted to identify optimal strategies to harmonize amyloid imaging data acquired using different tracers.

Published
2019

25. Early neurotransmitters changes in prodromal frontotemporal dementia: A GENFI study

Author

Esteve, Aitana Sogorb, Heller, Carolin, Greaves, Caroline V., Zetterberg, Henrik, Swift, Imogen J., Samra, Kiran, Shafei, Rachelle, Timberlake, Carolyn, Cope, Thomas, Rittman, Timothy, Arighi, Andrea, Fenoglio, Chiara, Scarpini, Elio, Fumagalli, Giorgio, Borracci, Vittoria, Rossi, Giacomina, Giaccone, Giorgio, Di Fede, Giuseppe, Caroppo, Paola, Tiraboschi, Pietro, Prioni, Sara, Redaelli, Veronica, Tang-Wai, David, Rogaeva, Ekaterina, Castelo-Branco, Miguel, Freedman, Morris, Keren, Ron, Black, Sandra, Mitchell, Sara, Shoesmith, Christen, Bartha, Robart, Rademakers, Rosa, Poos, Jackie, Papma, Janne M., Giannini, Lucia, van Minkelen, Rick, Pijnenburg, Yolande, Nacmias, Benedetta, Ferrari, Camilla, Polito, Cristina, Lombardi, Gemma, Bessi, Valentina, Veldsman, Michele, Andersson, Christin, Thonberg, Hakan, Öijerstedt, Linn, Jelic, Vesna, Thompson, Paul, Langheinrich, Tobias, Lladó, Albert, Antonell, Anna, Olives, Jaume, Balasa, Mircea, Bargalló, Nuria, Borrego-Ecija, Sergi, Verdelho, Ana, Maruta, Carolina, Ferreira, Catarina B., Miltenberger, Gabriel, do Couto, Frederico Simões, Gabilondo, Alazne, Gorostidi, Ana, Villanua, Jorge, Cañada, Marta, Tainta, Mikel, Zulaica, Miren, Barandiaran, Myriam, Alves, Patricia, Bender, Benjamin, Wilke, Carlo, Graf, Lisa, Vogels, Annick, Vandenbulcke, Mathieu, Van Damme, Philip, Bruffaerts, Rose, Poesen, Koen, Rosa-Neto, Pedro, Gauthier, Serge, Camuzat, Agnès, Brice, Alexis, Bertrand, Anne, Funkiewiez, Aurélie, Rinaldi, Daisy, Saracino, Dario, Colliot, Olivier, Sayah, Sabrina, Prix, Catharina, Wlasich, Elisabeth, Wagemann, Olivia, Loosli, Sandra, Schönecker, Sonja, Hoegen, Tobias, Lombardi, Jolina, Anderl-Straub, Sarah, Rollin, Adeline, Kuchcinski, Gregory, Bertoux, Maxime, Lebouvier, Thibaud, Deramecourt, Vincent, Santiago, Beatriz, Duro, Diana, Leitão, Maria João, Almeida, Maria Rosario, Tábuas-Pereira, Miguel, Afonso, Sónia, Premi, Enrico, Pengo, Marta, Mattioli, Irene, Cantoni, Valentina, Dukart, Juergen, Gasparotti, Roberto, Buratti, Emanuele, Padovani, Alessandro, Bocchetta, Martina, Todd, Emily G., Bouzigues, Arabella, Cash, David M., Convery, Rhian S., Russell, Lucy L., Foster, Phoebe, Thomas, David L., van Swieten, John C., Jiskoot, Lize C., Seelaar, Harro, Galimberti, Daniela, Sanchez-Valle, Raquel, Laforce, Robert, Jr, Moreno, Fermin, Synofzik, Matthis, Graff, Caroline, Masellis, Mario, Tartaglia, Maria Carmela, Rowe, James B., Tsvetanov, Kamen A., Vandenberghe, Rik, Finger, Elizabeth, de Mendonça, Alexandre, Santana, Isabel, Butler, Chris R., Ducharme, Simon, Gerhard, Alexander, Levin, Johannes, Otto, Markus, Sorbi, Sandro, Le Ber, Isabelle, Pasquier, Florence, Rohrer, Jonathan D., and Borroni, Barbara

Published
2023
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26. Proposal of new diagnostic criteria for fatal familial insomnia

Author

Chu, Min, Xie, Kexin, Zhang, Jing, Chen, Zhongyun, Ghorayeb, Imad, Rupprecht, Sven, Reder, Anthony T., Garay, Arturo, Honda, Hiroyuki, Nagayama, Masao, Shi, Qi, Zhan, Shuqin, Nan, Haitian, Zhang, Jiatang, Guan, Hongzhi, Cui, Li, Guo, Yanjun, Rosa-Neto, Pedro, Gauthier, Serge, Wang, Jiawei, Dong, Xiaoping, and Wu, Liyong

Published
2022
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28. Contributors

Author

Asconapé, Jorge J., primary, Bruinvels, Jacques, additional, Hill, Raymond G., additional, Johnston, Graham A.R., additional, Jost, Wolfgang, additional, López-Muñoz, Francisco, additional, Parnham, Michael J., additional, Remington, Gary, additional, Riederer, Peter, additional, Rujescu, Dan, additional, Seeman, Mary V., additional, Bacq, Zénon M., additional, Binnie, C.D., additional, Carlsson, Arvid, additional, Deniker, Pierre, additional, Gauthier, Serge, additional, Haefely, Willy, additional, Holzer, Peter, additional, Janssen, P.A.J., additional, Kline, Nathan S., additional, Lehmann, Heinz E., additional, Lembeck, Fred, additional, Meijer, J.W.A., additional, Meinardi, H., additional, Mishra, R., additional, Sourkes, Theodore L., additional, Sulser, F., additional, Tollenaere, J.P., additional, and Zeller,, E. Albert, additional

Published
2023
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30. Bibliography and Supplemental Bibliography

Author

Caplan, Ronald, primary, Morais, José A., additional, Fuks, Abraham, additional, Gauthier, Serge, additional, Gold, Phil, additional, Beauchet, Olivier, additional, and Bergman, Howard, additional

Published
2022
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33. Biomarker modeling of Alzheimer’s disease using PET-based Braak staging

Author

Therriault, Joseph, Pascoal, Tharick A., Lussier, Firoza Z., Tissot, Cécile, Chamoun, Mira, Bezgin, Gleb, Servaes, Stijn, Benedet, Andrea L., Ashton, Nicholas J., Karikari, Thomas K., Lantero-Rodriguez, Juan, Kunach, Peter, Wang, Yi-Ting, Fernandez-Arias, Jaime, Massarweh, Gassan, Vitali, Paolo, Soucy, Jean-Paul, Saha-Chaudhuri, Paramita, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, and Rosa-Neto, Pedro

Published
2022
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34. The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study

Author

Chertkow, Howard, Borrie, Michael, Whitehead, Victor, Black, Sandra E, Feldman, Howard H, Gauthier, Serge, Hogan, David B, Masellis, Mario, McGilton, Katherine, Rockwood, Kenneth, Tierney, Mary C, Andrew, Melissa, Hsiung, Ging-Yuek R, Camicioli, Richard, Smith, Eric E, Fogarty, Jennifer, Lindsay, Joseph, Best, Sarah, Evans, Alan, Das, Samir, Mohaddes, Zia, Pilon, Randi, Poirier, Judes, Phillips, Natalie A, MacNamara, Elizabeth, Dixon, Roger A, Duchesne, Simon, MacKenzie, Ian, and Rylett, R Jane

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Clinical Research, Prevention, Behavioral and Social Science, Aging, Neurodegenerative, Brain Disorders, Dementia, Basic Behavioral and Social Science, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Acquired Cognitive Impairment, Alzheimer's Disease, Neurological, Good Health and Well Being, Canada, Cohort Studies, Female, Humans, Longitudinal Studies, Male, Neurodegenerative Diseases, Research Design, Cohort study, Frontotemporal dementia, Biomarkers, Diagnosis, Alzheimers, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences
Abstract

BackgroundThe Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) cohort study of the Canadian Consortium on Neurodegeneration in Aging (CCNA) is a national initiative to catalyze research on dementia, set up to support the research agendas of CCNA teams. This cross-country longitudinal cohort of 2310 deeply phenotyped subjects with various forms of dementia and mild memory loss or concerns, along with cognitively intact elderly subjects, will test hypotheses generated by these teams.MethodsThe COMPASS-ND protocol, initial grant proposal for funding, fifth semi-annual CCNA Progress Report submitted to the Canadian Institutes of Health Research December 2017, and other documents supplemented by modifications made and lessons learned after implementation were used by the authors to create the description of the study provided here.ResultsThe CCNA COMPASS-ND cohort includes participants from across Canada with various cognitive conditions associated with or at risk of neurodegenerative diseases. They will undergo a wide range of experimental, clinical, imaging, and genetic investigation to specifically address the causes, diagnosis, treatment, and prevention of these conditions in the aging population. Data derived from clinical and cognitive assessments, biospecimens, brain imaging, genetics, and brain donations will be used to test hypotheses generated by CCNA research teams and other Canadian researchers. The study is the most comprehensive and ambitious Canadian study of dementia. Initial data posting occurred in 2018, with the full cohort to be accrued by 2020.ConclusionAvailability of data from the COMPASS-ND study will provide a major stimulus for dementia research in Canada in the coming years.

Published
2019

36. Structural brain splitting is a hallmark of Granulin-related frontotemporal dementia

Author

Afonso, Sónia, Almeida, Maria Rosario, Andersson, Christin, Antonell, Anna, Arighi, Andrea, Balasa, Mircea, Barandiaran, Myriam, Bargalló, Nuria, Bartha, Robart, Bender, Benjamin, Bertoux, Maxime, Bertrand, Anne, Bessi, Valentina, Black, Sandra, Borrego-Ecija, Sergi, Bouzigues, Arabella, Bras, Jose, Brice, Alexis, Bruffaerts, Rose, Camuzat, Agnès, Cañada, Marta, Cantoni, Valentina, Caroppo, Paola, Castelo-Branco, Miguel, Colliot, Olivier, Cope, Thomas, Deramecourt, Vincent, Fede, Giuseppe Di, Díez, Alina, Duro, Diana, Fenoglio, Chiara, Ferrari, Camilla, Ferreira, Catarina B., Fox, Nick, Freedman, Morris, Fumagalli, Giorgio, Funkiewiez, Aurélie, Gabilondo, Alazne, Gauthier, Serge, Giaccone, Giorgio, Gorostidi, Ana, Greaves, Caroline, Guerreiro, Rita, Heller, Carolin, Hoegen, Tobias, Indakoetxea, Begoña, Jelic, Vesna, Karnath, Hans-Otto, Keren, Ron, Kuchcinski, Gregory, Langheinrich, Tobias, Lebouvier, Thibaud, Leitão, Maria João, Lladó, Albert, Lombardi, Gemma, Lombardi, Jolina, Loosli, Sandra, Maruta, Carolina, Mead, Simon, Meeter, Lieke, Miltenberger, Gabriel, van Minkelen, Rick, Mitchell, Sara, Moore, Katrina, Nacmias, Benedetta, Nelson, Annabel, Nicholas, Jennifer, Öijerstedt, Linn, Olives, Jaume, Ourselin, Sebastien, Panman, Jessica, Papma, Janne M., Pijnenburg, Yolande, Polito, Cristina, Prioni, Sara, Prix, Catharina, Rademakers, Rosa, Redaelli, Veronica, Rinaldi, Daisy, Rittman, Tim, Rogaeva, Ekaterina, Rollin, Adeline, Rosa-Neto, Pedro, Rossi, Giacomina, Rossor, Martin, Santiago, Beatriz, Saracino, Dario, Sayah, Sabrina, Scarpini, Elio, Schönecker, Sonja, Shafei, Rachelle, Shoesmith, Christen, Swift, Imogen, Tábuas-Pereira, Miguel, Tainta, Mikel, Taipa, Ricardo, Tang-Wai, David, Thomas, David L, Thompson, Paul, Thonberg, Hakan, Timberlake, Carolyn, Tiraboschi, Pietro, Van Damme, Philip, Vandenbulcke, Mathieu, Veldsman, Michele, Verdelho, Ana, Villanua, Jorge, Warren, Jason, Wilke, Carlo, Woollacott, Ione, Wlasich, Elisabeth, Zetterberg, Henrik, Zulaica, Miren, Gazzina, Stefano, Grassi, Mario, Premi, Enrico, Alberici, Antonella, Benussi, Alberto, Archetti, Silvana, Gasparotti, Roberto, Bocchetta, Martina, Cash, David M., Todd, Emily G., Peakman, Georgia, Convery, Rhian S., van Swieten, John C., Jiskoot, Lize C., Seelaar, Harro, Sanchez-Valle, Raquel, Moreno, Fermin, Laforce, Robert, Jr, Graff, Caroline, Synofzik, Matthis, Galimberti, Daniela, Rowe, James B., Masellis, Mario, Tartaglia, Maria Carmela, Finger, Elizabeth, Vandenberghe, Rik, de Mendonça, Alexandre, Tagliavini, Fabrizio, Butler, Chris R., Santana, Isabel, Gerhard, Alexander, Ber, Isabelle Le, Pasquier, Florence, Ducharme, Simon, Levin, Johannes, Danek, Adrian, Sorbi, Sandro, Otto, Markus, Rohrer, Jonathan D., and Borroni, Barbara

Published
2022
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37. Examining empathy deficits across familial forms of frontotemporal dementia within the GENFI cohort

Author

Afonso, Sónia, Almeida, Maria Rosario, Anderl-Straub, Sarah, Andersson, Christin, Antonell, Anna, Archetti, Silvana, Arighi, Andrea, Balasa, Mircea, Barandiaran, Myriam, Bargalló, Nuria, Bartha, Robart, Bender, Benjamin, Benussi, Alberto, Bertoux, Maxime, Bertrand, Anne, Bessi, Valentina, Black, Sandra, Borrego-Ecija, Sergi, Bras, Jose, Brice, Alexis, Bruffaerts, Rose, Camuzat, Agnès, Cañada, Marta, Cantoni, Valentina, Caroppo, Paola, Cash, David, Castelo-Branco, Miguel, Colliot, Olivier, Cope, Thomas, Deramecourt, Vincent, de Arriba, María, Di Fede, Giuseppe, Díez, Alina, Duro, Diana, Fenoglio, Chiara, Ferrari, Camilla, Ferreira, Catarina B., Fox, Nick, Freedman, Morris, Fumagalli, Giorgio, Funkiewiez, Aurélie, Gabilondo, Alazne, Gasparotti, Roberto, Gauthier, Serge, Gazzina, Stefano, Giaccone, Giorgio, Gorostidi, Ana, Greaves, Caroline, Guerreiro, Rita, Heller, Carolin, Hoegen, Tobias, Indakoetxea, Begoña, Jelic, Vesna, Karnath, Hans-Otto, Keren, Ron, Kuchcinski, Gregory, Langheinrich, Tobias, Lebouvier, Thibaud, Leitão, Maria João, Lladó, Albert, Lombardi, Gemma, Loosli, Sandra, Maruta, Carolina, Mead, Simon, Meeter, Lieke, Miltenberger, Gabriel, van Minkelen, Rick, Mitchell, Sara, Moore, Katrina, Nacmias, Benedetta, Nelson, Annabel, Öijerstedt, Linn, Olives, Jaume, Ourselin, Sebastien, Padovani, Alessandro, Panman, Jessica, Papma, Janne M., Pijnenburg, Yolande, Polito, Cristina, Premi, Enrico, Prioni, Sara, Prix, Catharina, Rademakers, Rosa, Redaelli, Veronica, Rinaldi, Daisy, Rittman, Tim, Rogaeva, Ekaterina, Rollin, Adeline, Rosa-Neto, Pedro, Rossi, Giacomina, Rossor, Martin, Santiago, Beatriz, Saracino, Dario, Sayah, Sabrina, Scarpini, Elio, Schönecker, Sonja, Seelaar, Harro, Semler, Elisa, Shafei, Rachelle, Shoesmith, Christen, Swift, Imogen, Tábuas-Pereira, Miguel, Tainta, Mikel, Taipa, Ricardo, Tang-Wai, David, Thomas, David L., Thompson, Paul, Thonberg, Hakan, Timberlake, Carolyn, Tiraboschi, Pietro, Todd, Emily, Van Damme, Philip, Vandenbulcke, Mathieu, Veldsman, Michele, Verdelho, Ana, Villanua, Jorge, Warren, Jason, Wilke, Carlo, Woollacott, Ione, Wlasich, Elisabeth, Zetterberg, Henrik, Zulaica, Miren, Foster, Phoebe H., Russell, Lucy L., Peakman, Georgia, Convery, Rhian S., Bouzigues, Arabella, Greaves, Caroline V., Bocchetta, Martina, Cash, David M., van Swieten, John C., Jiskoot, Lize C., Moreno, Fermin, Sanchez-Valle, Raquel, Laforce, Robert, Graff, Caroline, Masellis, Mario, Tartaglia, Carmela, Rowe, James B., Borroni, Barbara, Finger, Elizabeth, Synofzik, Matthis, Galimberti, Daniela, Vandenberghe, Rik, de Mendonça, Alexandre, Butler, Chris R., Gerhard, Alex, Ducharme, Simon, Le Ber, Isabelle, Tagliavini, Fabrizio, Santana, Isabel, Pasquier, Florence, Levin, Johannes, Danek, Adrian, Otto, Markus, Sorbi, Sandro, and Rohrer, Jonathan D.

Published
2022
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40. Author Correction: [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease

Author

Pascoal, Tharick A., Chamoun, Mira, Lax, Elad, Wey, Hsiao-Ying, Shin, Monica, Ng, Kok Pin, Kang, Min Su, Mathotaarachchi, Sulantha, Benedet, Andrea L., Therriault, Joseph, Lussier, Firoza Z., Schroeder, Frederick A., DuBois, Jonathan M., Hightower, Baileigh G., Gilbert, Tonya M., Zürcher, Nicole R., Wang, Changning, Hopewell, Robert, Chakravarty, Mallar, Savard, Melissa, Thomas, Emilie, Mohaddes, Sara, Farzin, Sarah, Salaciak, Alyssa, Tullo, Stephanie, Cuello, A. Claudio, Soucy, Jean-Paul, Massarweh, Gassan, Hwang, Heungsun, Kobayashi, Eliane, Hyman, Bradley T., Dickerson, Bradford C., Guiot, Marie-Christine, Szyf, Moshe, Gauthier, Serge, Hooker, Jacob M., and Rosa-Neto, Pedro

Published
2022
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41. [11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease

Author

Pascoal, Tharick A., Chamoun, Mira, Lax, Elad, Wey, Hsiao-Ying, Shin, Monica, Ng, Kok Pin, Kang, Min Su, Mathotaarachchi, Sulantha, Benedet, Andrea L., Therriault, Joseph, Lussier, Firoza Z., Schroeder, Frederick A., DuBois, Jonathan M., Hightower, Baileigh G., Gilbert, Tonya M., Zürcher, Nicole R., Wang, Changning, Hopewell, Robert, Chakravarty, Mallar, Savard, Melissa, Thomas, Emilie, Mohaddes, Sara, Farzin, Sarah, Salaciak, Alyssa, Tullo, Stephanie, Cuello, A. Claudio, Soucy, Jean-Paul, Massarweh, Gassan, Hwang, Heungsun, Kobayashi, Eliane, Hyman, Bradley T., Dickerson, Bradford C., Guiot, Marie-Christine, Szyf, Moshe, Gauthier, Serge, Hooker, Jacob M., and Rosa-Neto, Pedro

Published
2022
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42. Corrigendum to “Hippocampus and amygdala volumes from magnetic resonance images in children: Assessing accuracy of FreeSurfer and FSL against manual segmentation”[NeuroImage 129 (2016) 1–14]

Author

Schoemaker, Dorothee, Buss, Claudia, Head, Kevin, Sandman, Curt A, Davis, Elysia P, Chakravarty, M Mallar, Gauthier, Serge, and Pruessner, Jens C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences, Health sciences
Abstract

The authors discovered an error in Fig. 4 of the published manuscript. The graphs displayed in Fig. 4-B correspond to a replication of those presented in Fig. 4-A. While the graphs in Fig. 4-A are accurate, the graphs in Fig. 4-B should instead be showing correlations between manual segmentation and FSL-FIRST volumes (not FreeSurfer as in the previously published version). Please find here the rectified Fig. 4. The correlation coefficients presented in the results section of the manuscript are accurate and thus, the manuscript itself remains unaffected by this error. LEGEND (unchanged) [Figure presented] The authors would like to apologise for any inconvenience caused.

Published
2018

43. Anosognosia predicts default mode network hypometabolism and clinical progression to dementia

Author

Therriault, Joseph, Ng, Kok Pin, Pascoal, Tharick A, Mathotaarachchi, Sulantha, Kang, Min Su, Struyfs, Hanne, Shin, Monica, Benedet, Andrea L, Walpola, Ishan C, Nair, Vasavan, Gauthier, Serge, Rosa-Neto, Pedro, Initiative, For the Alzheimer's Disease Neuroimaging, Initiative, Alzheimer's Disease Neuroimaging, Weiner, Michael W, Aisen, Paul, Petersen, Ronald, Jack, Clifford, Jagust, William, Morris, John C, Saykin, Andrew J, Trojanowski, John Q, Toga, Arthur W, and Beckett, Laurel

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Neurodegenerative, Dementia, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Aging, Clinical Research, Brain Disorders, Mental Health, Alzheimer's Disease, Neurological, Aged, Agnosia, Amyloid, Aniline Compounds, Apolipoprotein E4, Biomarkers, Brain, Cognitive Dysfunction, Disease Progression, Ethylene Glycols, Female, Fluorodeoxyglucose F18, Follow-Up Studies, Humans, Male, Prognosis, Radiopharmaceuticals, Alzheimer's Disease Neuroimaging Initiative, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences
Abstract

ObjectiveTo identify the pathophysiologic mechanisms and clinical significance of anosognosia for cognitive decline in mild cognitive impairment.MethodsWe stratified 468 patients with amnestic mild cognitive impairment into intact and impaired awareness groups, determined by the discrepancy between the patient and the informant score on the Everyday Cognition questionnaire. Voxel-based linear regression models evaluated the associations between self-awareness status and baseline β-amyloid load, measured by [18F]florbetapir, and the relationships between awareness status and regional brain glucose metabolism measured by [18F]fluorodeoxyglucose at baseline and at 24-month follow-up. Multivariate logistic regression tested the association of awareness status with conversion from amnestic mild cognitive impairment to dementia.ResultsWe found that participants with impaired awareness had lower [18F]fluorodeoxyglucose uptake and increased [18F]florbetapir uptake in the posterior cingulate cortex at baseline. In addition, impaired awareness in mild cognitive impairment predicted [18F]fluorodeoxyglucose hypometabolism in the posterior cingulate cortex, left basal forebrain, bilateral medial temporal lobes, and right lateral temporal lobe over 24 months. Furthermore, participants with impaired awareness had a nearly 3-fold increase in likelihood of conversion to dementia within a 2-year time frame.ConclusionsOur results suggest that anosognosia is linked to Alzheimer disease pathophysiology in vulnerable structures, and predicts subsequent hypometabolism in the default mode network, accompanied by an increased risk of progression to dementia. This highlights the importance of assessing awareness of cognitive decline in the clinical evaluation and management of individuals with amnestic mild cognitive impairment.

Published
2018

44. CYP2C19 variant mitigates Alzheimer disease pathophysiology in vivo and postmortem

Author

Benedet, Andréa L, Yu, Lei, Labbe, Aurélie, Mathotaarachchi, Sulantha, Pascoal, Tharick A, Shin, Monica, Kang, Min-Su, Gauthier, Serge, Rouleau, Guy A, Poirier, Judes, Bennett, David A, Rosa-Neto, Pedro, Weiner, Michael W, Aisen, Paul, Petersen, Ronald, Jack, Clifford, Jagust, William, Morris, John C, Saykin, Andrew J, Trojanowski, John Q, Toga, Arthur W, and Beckett, Laurel

Subjects
Pharmacology and Pharmaceutical Sciences, Biological Sciences, Biomedical and Clinical Sciences, Neurodegenerative, Dementia, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Aging, Neurosciences, Brain Disorders, Genetics, Alzheimer's Disease, 2.1 Biological and endogenous factors, Aetiology, Neurological, Alzheimer's Disease Neuroimaging Initiative, Clinical sciences
Abstract

ObjectiveTo verify whether CYP polymorphisms are associated with amyloid-β (Aβ) pathology across the spectrum of clinical Alzheimer disease using in vivo and postmortem data from 2 independent cohorts.MethodsA candidate-gene approach tested the association between 5 genes (28 single nucleotide polymorphisms) and Aβ load measured in vivo by the global [18F]florbetapir PET standardized uptake value ratio (SUVR) in 338 Alzheimer's Disease Neuroimaging Initiative participants. Significant results were then tested using plasma Aβ and CSF Aβ and Aβ/phosphorylated tau (Aβ/p-tau) ratio in the same cohort. The significant association was also generalized to postmortem Aβ load measurement in the Rush Religious Orders Study/Memory and Aging Project cohorts. In addition, global cognition was used as a phenotype in the analysis in both cohorts.ResultsAnalysis of Aβ PET identified a variant in the CYP2C19 gene (rs4388808; p = 0.0006), in which carriers of the minor allele (MA) had a lower global SUVR. A voxel-wise analysis revealed that the variant is associated with a lower Aβ load in the frontal, inferior temporal, and posterior cingulate cortices. MA carriers also had higher CSF Aβ (p = 0.003) and Aβ/p-tau ratio (p = 0.02) but had no association with Aβ plasma levels. In postmortem brains, MA carriers had a lower Aβ load (p = 0.03). Global cognition was higher in MA carriers, which was found to be mediated by Aβ.ConclusionsTogether, these findings point to an association between CYP2C19 polymorphism and Aβ pathology, suggesting a protective effect of the MA of rs4388808. Despite the several possibilities in which CYP2C19 affects brain Aβ, the biological mechanism by which this genetic variation may act as a protective factor merits further investigation.

Published
2018

47. Focusing on earlier diagnosis of Alzheimer's disease

Author

Frederiksen, Kristian Steen, primary, Arus, Xavier Morato, additional, Zetterberg, Henrik, additional, Gauthier, Serge, additional, Boada, Mercè, additional, Pytel, Vanesa, additional, Hahn-Pedersen, Julie, additional, Solís Tarazona, Luis Rafael, additional, and Mattke, Soeren, additional

Published
2024
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48. Predicting functional decline in aging and Alzheimer’s disease with PET-based Braak staging

Author

Macedo, Arthur C, primary, Therriault, Joseph, additional, Tissot, Cécile, additional, Fernandez Arias, Jaime, additional, Ferreira, Pamela C L, additional, Vitali, Paolo, additional, Servaes, Stijn, additional, Rahmouni, Nesrine, additional, Vermeiren, Marie, additional, Bezgin, Gleb, additional, Lussier, Firoza Z, additional, Stevenson, Jenna, additional, Wang, Yi-Ting, additional, Socualaya, Kely Quispialaya, additional, Kunach, Peter, additional, Nazneen, Tahnia, additional, Hosseini, Seyyed Ali, additional, Pallen, Vanessa, additional, Stevenson, Alyssa, additional, Ferrari-Souza, João Pedro, additional, Bellaver, Bruna, additional, Leffa, Douglas Teixeira, additional, Ng, Kok Pin, additional, Zimmer, Eduardo R, additional, Pascoal, Tharick A, additional, Gauthier, Serge, additional, and Rosa-Neto, Pedro, additional

Published
2024
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49. Real-Time Detection of Eating Activity in Elderly People with Dementia Using Face Alignment and Facial Landmarks

Author

Nour, Mhamed, Gardoni, Mickaël, Renaud, Jean, Gauthier, Serge, Rannenberg, Kai, Editor-in-Chief, Soares Barbosa, Luís, Editorial Board Member, Goedicke, Michael, Editorial Board Member, Tatnall, Arthur, Editorial Board Member, Neuhold, Erich J., Editorial Board Member, Stiller, Burkhard, Editorial Board Member, Tröltzsch, Fredi, Editorial Board Member, Pries-Heje, Jan, Editorial Board Member, Kreps, David, Editorial Board Member, Reis, Ricardo, Editorial Board Member, Furnell, Steven, Editorial Board Member, Mercier-Laurent, Eunika, Editorial Board Member, Winckler, Marco, Editorial Board Member, Malaka, Rainer, Editorial Board Member, Nyffenegger, Felix, editor, Ríos, José, editor, Rivest, Louis, editor, and Bouras, Abdelaziz, editor

Published
2020
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50. Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer’s disease

Author

Kang, Min Su, Aliaga, Arturo Aliaga, Shin, Monica, Mathotaarachchi, Sulantha, Benedet, Andrea L., Pascoal, Tharick A., Therriault, Joseph, Chamoun, Mira, Savard, Melissa, Devenyi, Gabriel A., Mathieu, Axel, Chakravarty, M. Mallar, Sandelius, Åsa, Blennow, Kaj, Zetterberg, Henrik, Soucy, Jean-Paul, Cuello, A. Claudio, Massarweh, Gassan, Gauthier, Serge, and Rosa-Neto, Pedro

Published
2021
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