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Stable open- and closed-shell Pd(II) and Cu(II) complexes of hexaethyl tripyrrin-1,14-dione (TD1) produce triplet, doublet or singlet states depending on the metal center and the redox state of the ligand. Pd(II) and Cu(II) form neutral TD1 complexes featuring ligand-based radicals, thus resulting in doublet and triplet states, respectively. The reversible one-electron oxidation of the complexes removes an unpaired electron from the ligand, generating singlet and doublet states. The optical properties and time-resolved dynamics of these systems are studied here using steady-state and ultrafast transient absorption (pump-probe) measurements. Fast relaxation with recovery of the ground state in tens of picoseconds is observed for the copper neutral radical and oxidized complexes as well as for the palladium neutral radical complex. Significantly longer timescales are observed for the oxidized palladium complex. The ability to tune the overall spin state of the complexes through their stable open-shell configurations as well as the reversible redox activity of the tripyrrolic systems makes them particularly interesting for catalytic applications as well as exploring magnetism and conductivity properties. [ABSTRACT FROM AUTHOR]

The combination of reversible redox chemistry and bright redox‐responsive emission properties is key to the development of electrofluorochromic switches for applications in bioimaging and optoelectronics. Herein, the redox‐active dipyrrin‐1,9‐dione fragment, which is characteristic of the propentdyopent family of heme metabolites and urinary pigments, is employed for the synthesis of a BODIPY analog. This boron difluoride complex exhibits bright fluorescence in organic solvents and a significant ipsochromic shift to the cyan region when compared to typical green BODIPY dyes. Electrochemical and spectroscopic measurements show that the dipyrrindione ligand acts as an electron reservoir by hosting an unpaired spin upon one‐electron reduction. This ligand‐based redox event reversibly abolishes the fluorescence emission, thus switching off the novel electrofluorochromic system. The redox‐active dipyrrindione scaffold of the propentdyopent family of heme metabolites is incorporated into an electrofluorochromic BODIPY analog. Its bright cyan fluorescence is switched off by reversible one‐electron reduction. [ABSTRACT FROM AUTHOR]

This study aims to present a Citation analysis of Ph.D. theses in Education submitted to Ch. Charan Singh University, Meerut. The paper analyzes a citation study of 312 theses which are submitted to CCS University during the period 1971-2015. The paper covers the citation analyses of year-wise submission of Ph.D. theses, the rate of collaborative authorship of cited documents, use pattern, year-wise distribution of citations and the number of guide in each thesis. Also deals with the credibility of guide, authorship pattern of journals cited and study the ranked journals cited in each thesis of Education submitted to the university. [ABSTRACT FROM AUTHOR]

Sirtinol, a Schiff base derived from 2-hydroxy-1-naphthaldehyde, is an inhibitor of sirtuin proteins, a family of deacetylases active in gene regulation and relevant to the study of cancer growth. The formation of copper(II) and zinc(II) complexes of sirtinol is investigated by spectroscopic and structural methods. The molecular structure of this protein inhibitor allows for coordination of first-row transition metals in both tridentate and bidentate fashion. In addition, assays in cultured breast cancer cells reveal that CuII(sirtinol−H)2and previously reported FeIII(sirtinol−H)(NO3)2present enhanced cytotoxicity when compared to the free ligand, and that the ferric complex causes an increase in intracellular oxidative stress. Transition metal coordination in the biological milieu could therefore contribute additional effects to the biological profile of sirtinol. [ABSTRACT FROM AUTHOR]

Introduction: Intraoperative record form is one of the cardinal parts of anesthesia practices. Ideally, it should contain complete information about patients under anesthesia and intraoperative events. It serves as valuable information for subsequent patient management, research, or during medicolegal conditions. The objective of this study was to assess the practice and completeness of manual intraoperative anesthesia record keeping., Methods: A descriptive cross-sectional study was conducted from May 1 to July 31, 2021, in the postoperative ward of Kathmandu Medical College, which is a multispecialty tertiary care center. Approval from the ethical committee of Kathmandu Medical College Teaching Hospital was obtained (Reference: 2603202105) before conducting the study. Convenience sampling was used. The data were entered in Microsoft Excel and statistical analysis was done using Statistical Package for the Social Sciences version 20. Point estimate was done at 95% Confidence Interval and data present in numbers and percentages. We devised forty-two variables, which included demographics, personal identifiers, intraoperative events, anesthesia and airway management, intraoperative parameters, monitoring and medication., Results: The overall completion rate was 202 (52.59%) (47.6-57.57 at 95% Confidence Interval). Out of 42 variables, the completion rate of 14 variables was less than 50%. Among those were important parameters such as known allergies 94 (24.4%), Body mass index 50 (13%), intraoperative saturation of oxygen 104 (27%), intraoperative electrocardiogram recording 107 (27.8%), total fluid volume administered 45 (11.7%), patient status on transfer 84 (21.8%) had poor completion rate., Conclusions: Our intraoperative record form shows poor completion rate, which was similar to other studies. many important variables were missing and had incomplete data.