1. Efficient discrimination of transplutonium actinides by in vivo models.
- Author
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Pallares RM, An DD, Deblonde GJ, Kullgren B, Gauny SS, Jarvis EE, and Abergel RJ
- Abstract
Transplutonium actinides are among the heaviest elements whose macroscale chemical properties can be experimentally tested. Being scarce and hazardous, their chemistry is rather unexplored, and they have traditionally been considered a rather homogeneous group, with most of their characteristics extrapolated from lanthanide surrogates. Newly emerged applications for these elements, combined with their persistent presence in nuclear waste, however, call for a better understanding of their behavior in complex living systems. In this work, we explored the biodistribution and excretion profiles of four transplutonium actinides (
248 Cm,249 Bk,249 Cf and253 Es) in a small animal model, and evaluated their in vivo sequestration and decorporation by two therapeutic chelators, diethylenetriamine pentaacetic acid and 3,4,3-LI(1,2-HOPO) . Notably, the organ deposition patterns of those transplutonium actinides were element-dependent, particularly in the liver and skeleton, where lower atomic number radionuclides showed up to 7-fold larger liver/skeleton accumulation ratios. Nevertheless, the metal content in multiple organs was significantly decreased for all tested actinides, particularly in the liver, after administering the therapeutic agent 3,4,3-LI(1,2-HOPO) post-contamination. Lastly, the systematic comparison of the radionuclide biodistributions showed discernibly element-dependent organ depositions, which may provide insights into design rules for new bio-inspired chelating systems with high sequestration and separation performance., Competing Interests: R. J. A. and G. J.-P. D. are listed as inventors on patent applications filed by the Lawrence Berkeley National Laboratory (LBNL) and describing inventions related to the research results presented here. The authors declare no competing financial interest., (This journal is © The Royal Society of Chemistry.)- Published
- 2021
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