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21 results on '"Gauna, Carlotta"'

1. Offloading systems for the treatment of neuropathic foot ulcers in patients with diabetes mellitus: a meta-analysis of randomized controlled trials for the development of the Italian guidelines for the treatment of diabetic foot syndrome

Author

Gauna, Carlotta, Romeo, Francesco, Scatena, Alessia, Miranda, Cesare, Uccioli, Luigi, Vermigli, Cristiana, Volpe, Antonio, Bordieri, Corrado, Tramonta, Rodolfo, Ragghianti, Benedetta, Bandini, Giulia, Monami, Matteo, and Monge, Luca

Published
2024
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2. Effect of a multidisciplinary team approach in patients with diabetic foot ulcers on major adverse limb events (MALEs): systematic review and meta-analysis for the development of the Italian guidelines for the treatment of diabetic foot syndrome

Author

Meloni, Marco, Giurato, Laura, Monge, Luca, Miranda, Cesare, Scatena, Alessia, Ragghianti, Benedetta, Silverii, Giovanni Antonio, Vermigli, Cristiana, De Cassai, Alessandro, Volpe, Antonio, Tramonta, Rodolfo, Medea, Gerardo, Bordieri, Corrado, Falcone, Marco, Stefanon, Laura, Bernetti, Andrea, Cappella, Cristina, Gargiulo, Mauro, Lorenzoni, Valentina, Scevola, Germano, Stabile, Eugenio, Da Ros, Roberto, Murdolo, Giuseppe, Bianchini, Eleonora, Gaggia, Francesco, Gauna, Carlotta, Romeo, Francesco, Apicella, Matteo, Mantuano, Michele, Monami, Matteo, and Uccioli, Luigi

Published
2024
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3. Correction to: Development of the Italian clinical practice guidelines for the treatment of diabetic foot syndrome: design and methodological aspects

Author

Monami, Matteo, Scatena, Alessia, Miranda, Cesare, Monge, Luca, De Cassai, Alessandro, Volpe, Antonio, Tramonta, Rodolfo, Medea, Gerardo, Bordieri, Corrado, Falcone, Marco, Stefanon, Laura, Bernetti, Andrea, Cappella, Cristina, Gargiulo, Mauro, Lorenzoni, Valentina, Scevola, Germano, Stabile, Eugenio, Ragghianti, Benedetta, Silverii, Giovanni Antonio, da Ros, Roberto, Meloni, Marco, Giurato, Laura, Murdolo, Giuseppe, Bianchini, Eleonora, Gaggia, Francesco, Gauna, Carlotta, Romeo, Francesco, Apicella, Matteo, Mantuano, Michele, Uccioli, Luigi, and Vermigli, Cristiana

Published
2024
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4. Development of the Italian clinical practice guidelines for the treatment of diabetic foot syndrome: design and methodological aspects

Author

Monami, Matteo, Scatena, Alessia, Miranda, Cesare, Monge, Luca, De Cassai, Alessandro, Volpe, Antonio, Tramonta, Rodolfo, Medea, Gerardo, Bordieri, Corrado, Falcone, Marco, Stefanon, Laura, Bernetti, Andrea, Cappella, Cristina, Gargiulo, Mauro, Lorenzoni, Valentina, Scevola, Germano, Stabile, Eugenio, Ragghianti, Benedetta, Silverii, Giovanni Antonio, da Ros, Roberto, Meloni, Marco, Giurato, Laura, Murdolo, Giuseppe, Bianchini, Eleonora, Gaggia, Francesco, Gauna, Carlotta, Romeo, Francesco, Apicella, Matteo, Mantuano, Michele, Uccioli, Luigi, and Vermigli, Cristiana

Published
2023
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6. Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization

Author

Delhanty, Patric J.D., van Kerkwijk, Anke, Huisman, Martin, van de Zande, Bedette, Verhoef-Post, Miriam, Gauna, Carlotta, Hofland, Leo, Themmen, Axel P.N., and van der Lely, A.J.

Subjects
Unsaturated fatty acids -- Health aspects, Cell physiology -- Research, Somatotropin -- Receptors, Somatotropin -- Properties, Biological sciences
Abstract

The composition of the plasma membrane affects the responsiveness of ceils to metabolically important hormones such as insulin and vasoactive intestinal peptide. Ghrelin is a metabolically regulated hormone that activates the G protein-coupled receptor GH secretagogue receptor type la (GHSR) not only in the pituitary gland but also in peripheral tissues such as the pancreas, stomach, and T ceils in the circulation. We have investigated the effects of lipids and altered plasma membrane composition on GHSR activation. Oligounsaturated fatty acids (OFAs) disrupt the structure of membranes and make them more fluid. Prolonged (96 h), but not acute, treatment of the GHSR cells with the 18C OFAs oleic and linoleic acid caused a significant increase in sensitivity of the receptor to ghrelin ([EC.sub.50] reduced by a factor of 2.4 and 2.9 at 60 and 120 [micro]M OFAs, respectively). OFAs were found to block the inhibitory effects of ghrelin pretreatment on subsequent ghrelin responsiveness, suggesting that OFAs suppress desensitization of GHSR. Radioligand displacement studies did not show a significant shift in receptor binding after incubation with OFAs. However, it was found that OFA treatment suppressed GHSR internalization, likely explaining OFA-induced refractoriness to ligand-induced desensitization. The involvement of lipid rafts in this process was indicated by the altered responsiveness of GHSR under conditions that alter membrane cholesterol. In conclusion, our findings demonstrate the importance of membrane composition for GHSR activation and desensitization and indicate at least part of the mechanism through which OFAs and cholesterol could affect ghrelin's activity in vivo. ghrelin receptor fatty acids doi: 10.1152/ajpendo.00414.2009.

Published
2010

7. Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions

Author

Gauna, Carlotta, Kiewiet, Rosalie M., Janssen, Joop A.M.J.L., van de Zande, Bedette, Delhanty, Patric J.D., Ghigo, Ezio, Hofland, Leo J., Themmen, Axel P.N., and van der Lely, Aart Jan

Subjects
Glucose metabolism -- Research, Ghrelin -- Reorganization and restructuring, Diabetes -- Research, Insulin -- Structure-activity relationships, Insulin -- Research, Company restructuring/company reorganization, Company organization, Biological sciences
Abstract

Acylated and unacylated ghrelin (AG and UAG) are gut hormones that exert pleiotropic actions, including regulation of insulin secretion and glucose metabolism. In this study, we investigated whether AG and UAG differentially regulate portal and systemic insulin levels after a glucose load. We studied the effects of the administration of AG (30 nmol/kg), UAG (3 and 30 nmol/kg), the ghrelin receptor antagonist [D-[Lys.sup.3]]GHRP-6 (1 [micro]mol/kg), or various combinations of these compounds on portal and systemic levels of glucose and insulin after an intravenous glucose tolerance test (IVGTT, o-glucose 1 g/kg) in anesthetized fasted Wistar rats. UAG administration potently and dose-dependently enhanced the rise of insulin concentration induced by IVGTT in the portal and, to a lesser extent, the systemic circulation. This UAG-induced effect was completely blocked by the coadministration of exogenous AG at equimolar concentrations. Similarly to UAG, [o-[Lys.sup.3]]GHRP-6, alone or in combination with AG and UAG, strongly enhanced the portal insulin response to IVGTT, whereas exogenous AG alone did not exert any further effect. Our data demonstrate that, in glucose-stimulated conditions, exogenous UAG acts as a potent insulin secretagogue, whereas endogenous AG exerts a maximal tonic inhibition on glucose-induced insulin release. acylated ghrelin; insulin secretion; portal vein; rat

Published
2007

8. Ghrelin and the endocrine pancreas

Author

Broglio, Fabio, Gottero, Cristina, Benso, Andrea, Prodam, Flavia, Volante, Marco, Destefanis, Silvia, Gauna, Carlotta, Muccioli, Giampiero, Papotti, Mauro, van der Lely, Aart Jan, and Ghigo, Ezio

Published
2003
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14. Acetylcholine Regulates Ghrelin Secretion in Humans

Author

Broglio, Fabio, Gottero, Cristina, Van Koetsveld, Peter, Prodam, Flavia, Destefanis, Silvia, Benso, Andrea, Gauna, Carlotta, Hofland, Leo, Arvat, Emanuela, van der Lely, Aart Jan, and Ghigo, Ezio

Published
2004

18. Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats

Author

Granata, Riccarda, primary, Volante, Marco, additional, Settanni, Fabio, additional, Gauna, Carlotta, additional, Ghé, Corrado, additional, Annunziata, Marta, additional, Deidda, Barbara, additional, Gesmundo, Iacopo, additional, Abribat, Thierry, additional, van der Lely, Aart-Jan, additional, Muccioli, Giampiero, additional, Ghigo, Ezio, additional, and Papotti, Mauro, additional

Published
2010
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20. Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor

Author

Gauna, Carlotta, primary, Delhanty, Patric J.D., additional, van Aken, Maarten O., additional, Janssen, Joop A.M.J.L., additional, Themmen, Axel P.N., additional, Hofland, Leo J., additional, Culler, Michael, additional, Broglio, Fabio, additional, Ghigo, Ezio, additional, and van der Lely, Aart Jan, additional

Published
2006
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21. Ghrelin Secretion Is Inhibited by Either Somatostatin or Cortistatin in Humans

Author

Broglio, Fabio, primary, Koetsveld, Peter van, additional, Benso, Andrea, additional, Gottero, Cristina, additional, Prodam, Flavia, additional, Papotti, Mauro, additional, Muccioli, Giampiero, additional, Gauna, Carlotta, additional, Hofland, Leo, additional, Deghenghi, Romano, additional, Arvat, Emanuela, additional, van der Lely, Aart Jan, additional, and Ghigo, Ezio, additional

Published
2002
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