Search

Your search keyword '"Gault, Abigail"' showing total 15 results
Start Over Author "Gault, Abigail"
15 results on '"Gault, Abigail"'

1. Monitoring immunE DysregulAtion foLLowing Immune checkpOint-inhibitioN (MEDALLION): protocol for an observational cancer immunotherapy cohort study

Author

Gault, Abigail, Hogarth, Linda, Williams, Kristian C, Greystoke, Alastair, Rajan, Neil, Speight, Ally, Lamb, Christopher A, Bridgewood, Alison, Brown-Schofield, Lisa-Jayne, Rayner, Fiona, Isaacs, John D, Nsengimana, Jérémie, Stewart, Christopher J, Anderson, Amy E, Plummer, Ruth, and Pratt, Arthur G

Published
2024
Full Text
View/download PDF

2. COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study

Author

Gault, Abigail, Agnieszka, Michael, Bedair, Ahmed, Ghaus, Aisha, Akingboye, Akinfemi, Maynard, Alec, Pawsey, Alexander, Suwaidan, Ali Abdulnabi, Okines, Alicia, Massey, Alison, Kwan, Amy, Ferreira, Ana, Angelakas, Angelos, Wu, Anjui, Tivey, Ann, Armstrong, Anne, Madhan, Annet, Pillai, Annet, Poon-King, Ashley, Kurec, Bartlomiej, Usborne, Caroline, Dobeson, Caroline, Thirlwell, Christina, Mitchell, Christian, Sng, Christopher, Scrase, Christopher, Jingree, Christopher, Brunner, Clair, Fuller, Claire, Griffin, Clare, Barrington, Craig, Muller, Daniel, Ottaviani, Diego, Gilbert, Duncan, Tacconi, Eliana, Copson, Ellen, Renninson, Emily, Cattell, Emma, Burke, Emma, Smith, Fiona, Holt, Francesca, Soosaipillai, Gehan, Boyce, Hayley, Shaw, Heather, Hollis, Helen, Bowyer, Helen, Anil, Iris, Illingworth, Jack, Gibson, Jack, Bhosle, Jaishree, Best, James, Barrett, Jane, Noble, Jillian, Sacco, Joseph, Chacko, Joseph, Chackathayil, Julia, Banfill, Kathryn, Feeney, Laura, Horsley, Laura, Cammaert, Lauren, Mukherjee, Leena, Eastlake, Leonie, Devereaux, Louise, Melcher, Lucinda, Cook, Lucy, Teng, Mabel, Hewish, Madeleine, Bhattacharyya, Madhumita, Choudhury, Mahbuba, Baxter, Mark, Scott-Brown, Martin, Fittall, Matthew, Tilby, Michael, Rowe, Michael, Alihilali, Mohammed, Galazi, Myria, Yousaf, Nadia, Chopra, Neha, Cox, Nicola, Chan, Olivia, Sheikh, Omar, Ramage, Paul, Greaves, Paul, Leonard, Pauline, Hall, Peter S, Naksukpaiboon, Piangfan, Corrie, Pippa, Peck, Rahul, Sharkey, Rachel, Bolton, Rachel, Sargent, Rebecca, Jyothirmayi, Rema, Goldstein, Robert, Oakes, Roderick, Shotton, Rohan, Kanani, Ruhi, Board, Ruth, Pettengell, Ruth, Claydon, Ryan, Moody, Sam, Massalha, Samah, Kathirgamakarthigeyan, Sangary, Dolly, Saoirse, Derby, Sarah, Lowndes, Sarah, Benafif, Sarah, Eeckelaers, Sarah, Kingdon, Sarah, Ayers, Sarah, Brown, Sean, Ellis, Shawn, Parikh, Shefali, Pugh, Sian, Shamas, Simon, Wyatt, Simon, Grumett, Simon, Lau, Sin, Wong, Yien Ning Sophia, McGrath, Sophie, Cornthwaite, Stephanie, Hibbs, Stephen, Tillet, Tania, Rabbi, Taslima, Robinson, Tim, Roques, Tom, Angelis, Vasileios, Woodcock, Victoria, Brown, Victoria, Peng, YingYing, Drew, Yvette, Hudson, Zoe, Lee, Lennard Y W, Cazier, Jean-Baptiste, Starkey, Thomas, Briggs, Sarah E W, Arnold, Roland, Bisht, Vartika, Booth, Stephen, Campton, Naomi A, Cheng, Vinton W T, Collins, Graham, Curley, Helen M, Earwaker, Philip, Fittall, Matthew W, Gennatas, Spyridon, Goel, Anshita, Hartley, Simon, Hughes, Daniel J, Kerr, David, Lee, Alvin J X, Lee, Rebecca J, Lee, Siow Ming, Mckenzie, Hayley, Middleton, Chris P, Murugaesu, Nirupa, Newsom-Davis, Tom, Olsson-Brown, Anna C, Palles, Claire, Powles, Thomas, Protheroe, Emily A, Purshouse, Karin, Sharma-Oates, Archana, Sivakumar, Shivan, Smith, Ashley J, Topping, Oliver, Turnbull, Chris D, Várnai, Csilla, Briggs, Adam D M, Middleton, Gary, and Kerr, Rachel

Published
2020
Full Text
View/download PDF

10. Mortality Among Adults With Cancer Undergoing Chemotherapy or Immunotherapy and Infected With COVID-19

Author

Várnai, Csilla, Palles, Claire, Arnold, Roland, Curley, Helen M., Purshouse, Karin, Cheng, Vinton W. T., Booth, Stephen, Campton, Naomi A., Collins, Graham P., Hughes, Daniel J., Kulasekararaj, Austin G., Lee, Alvin J. X., Olsson-brown, Anna C., Sharma-oates, Archana, Van Hemelrijck, Mieke, Lee, Lennard Y. W., Kerr, Rachel, Middleton, Gary, Cazier, Jean-baptiste, Pugh, Sian, Corrie, Pippa, Bedair, Ahmed, Hewish, Madeleine, Leonard, Pauline, Illingworth, Jack, Hibbs, Stephen, Diamantis, Nicolaos, Massalha, Samah, Fuller, Claire, Usbourne, Caroline, Gilbert, Duncan, Davies, Jennifer, Newsom-davis, Tom, Sharkey, Rachel, Lee, Rebecca, Tivey, Ann, Shotton, Rohan, Griffin, Clare, Horsley, Laura, Shamas, Simon, Sacco, Joseph J, Choudhury, Madbuba, Noble, Jillian, Shaw, Heather, Bolton, Rachel, Ferreira, Ana, Hall, Peter, Ramage, Paul, Bhosle, Jaishree, Massey, Alison, Hill, Michaela, Mukherjee, Leena, Ghaus, Aisha, Derby, Sarah, Brown, Sean, Lowndes, Sarah, Dolly, Saorise, Russell, Beth, Moss, Charlotte, Muller, Daniel, Pillai, Annet, Lowe, Shakeel, Cook, Lucy, Scrase, Christopher, Jyothirmayi, Rema, Board, Ruth, Cornthwaite, Stephanie, Parikh, Shefail, Cattell, Emma, Cox, Nicola, Gault, Abigail, Moody, Sam, Dobeson, Caroline, Baxter, Mark, Roques, Tom, Pawsey, Alexander, Oakes, Roderick, Melcher, Lucinda, Chan, Olivia, Ayers, Sarah, Bowyer, Helen, Althohami, Mohammed, Mittal, Sajjan, Feeney, Laura, Aujayeb, Avinash, Sheikh, Omar, Kathirgamakarthigeyan, Sangary, Woodcock, Victoria, Holt, Francesca, Wyatt, Simon, Topping, Oliver, Tilby, Michael, Bhattacharyya, Madhumita, Burke, Emma, Ellis, Shawn, Chacko, Joseph, Rabbi, Taslima, Rowe, Michael, Sargent, Rebecca, Thirlwell, Christina, Gibson, Jack, Goldstein, Robert, Fittall, Mathew, Gennatas, Spyridon, Okines, Alicia, Best, James, Tillett, Tania, Renninson, Emily, Grumett, Simon, Barrington, Craig, Pettengell, Ruth, Peng, Yingyying, Chackathayil, Julia, Akingboye, Akinfemi, Hollis, Helen, Shin Chin, Ik, Bisht, Vartika, Hartley, Simon, Middleton, Christopher P, Goel, Anshita, Protheroe, Emily, Naksukpaiboon, Paingfan, Anil, Iris, Michell, Joel, D'costa, Jamie, Wu, Anjui, Ottaviani, Diego, Soosaipillai, Gehan, Galazi, Myria, Chopra, Neha, Benafif, Sarah, Sng, Christopher Ct, Wong, Sophia Yn, Scott-brown, Martin, Copson, Ellen, Robinson, Timothy, Hudson, Zoe, Smith, Fiona, Abdulnabi Mohamed, Ali-abdulnabi, Angelakas, Angelos, Eastlake, Leoni, Poon-king, Ashley, Brunner, Clair, Kwan, Amy, Maynard, Alec, Boyce, Hayley, Spurrell, Emma, Peck, Rahul, and Kurec, Bartlomiej

Subjects
Aged, 80 and over, Male, Lung Neoplasms, SARS-CoV-2, COVID-19, General Medicine, Middle Aged, United Kingdom, Cohort Studies, Drug Therapy, Hematologic Neoplasms, Humans, Female, Immunotherapy, Prospective Studies, Registries, Aged
Abstract

Importance Large cohorts of patients with active cancers and COVID-19 infection are needed to provide evidence of the association of recent cancer treatment and cancer type with COVID-19 mortality.Objective To evaluate whether systemic anticancer treatments (SACTs), tumor subtypes, patient demographic characteristics (age and sex), and comorbidities are associated with COVID-19 mortality.Design, Setting, and Participants The UK Coronavirus Cancer Monitoring Project (UKCCMP) is a prospective cohort study conducted at 69 UK cancer hospitals among adult patients (≥18 years) with an active cancer and a clinical diagnosis of COVID-19. Patients registered from March 18 to August 1, 2020, were included in this analysis.Exposures SACT, tumor subtype, patient demographic characteristics (eg, age, sex, body mass index, race and ethnicity, smoking history), and comorbidities were investigated.Main Outcomes and Measures The primary end point was all-cause mortality within the primary hospitalization.Results Overall, 2515 of 2786 patients registered during the study period were included; 1464 (58%) were men; and the median (IQR) age was 72 (62-80) years. The mortality rate was 38% (966 patients). The data suggest an association between higher mortality in patients with hematological malignant neoplasms irrespective of recent SACT, particularly in those with acute leukemias or myelodysplastic syndrome (OR, 2.16; 95% CI, 1.30-3.60) and myeloma or plasmacytoma (OR, 1.53; 95% CI, 1.04-2.26). Lung cancer was also significantly associated with higher COVID-19–related mortality (OR, 1.58; 95% CI, 1.11-2.25). No association between higher mortality and receiving chemotherapy in the 4 weeks before COVID-19 diagnosis was observed after correcting for the crucial confounders of age, sex, and comorbidities. An association between lower mortality and receiving immunotherapy in the 4 weeks before COVID-19 diagnosis was observed (immunotherapy vs no cancer therapy: OR, 0.52; 95% CI, 0.31-0.86).Conclusions and Relevance The findings of this study of patients with active cancer suggest that recent SACT is not associated with inferior outcomes from COVID-19 infection. This has relevance for the care of patients with cancer requiring treatment, particularly in countries experiencing an increase in COVID-19 case numbers. Important differences in outcomes among patients with hematological and lung cancers were observed

Published
2022
Full Text
View/download PDF

14. COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study

Author

Lee, Lennard Y W, primary, Cazier, Jean-Baptiste, additional, Starkey, Thomas, additional, Briggs, Sarah E W, additional, Arnold, Roland, additional, Bisht, Vartika, additional, Booth, Stephen, additional, Campton, Naomi A, additional, Cheng, Vinton W T, additional, Collins, Graham, additional, Curley, Helen M, additional, Earwaker, Philip, additional, Fittall, Matthew W, additional, Gennatas, Spyridon, additional, Goel, Anshita, additional, Hartley, Simon, additional, Hughes, Daniel J, additional, Kerr, David, additional, Lee, Alvin J X, additional, Lee, Rebecca J, additional, Lee, Siow Ming, additional, Mckenzie, Hayley, additional, Middleton, Chris P, additional, Murugaesu, Nirupa, additional, Newsom-Davis, Tom, additional, Olsson-Brown, Anna C, additional, Palles, Claire, additional, Powles, Thomas, additional, Protheroe, Emily A, additional, Purshouse, Karin, additional, Sharma-Oates, Archana, additional, Sivakumar, Shivan, additional, Smith, Ashley J, additional, Topping, Oliver, additional, Turnbull, Chris D, additional, Várnai, Csilla, additional, Briggs, Adam D M, additional, Middleton, Gary, additional, Kerr, Rachel, additional, Gault, Abigail, additional, Agnieszka, Michael, additional, Bedair, Ahmed, additional, Ghaus, Aisha, additional, Akingboye, Akinfemi, additional, Maynard, Alec, additional, Pawsey, Alexander, additional, Suwaidan, Ali Abdulnabi, additional, Okines, Alicia, additional, Massey, Alison, additional, Kwan, Amy, additional, Ferreira, Ana, additional, Angelakas, Angelos, additional, Wu, Anjui, additional, Tivey, Ann, additional, Armstrong, Anne, additional, Madhan, Annet, additional, Pillai, Annet, additional, Poon-King, Ashley, additional, Kurec, Bartlomiej, additional, Usborne, Caroline, additional, Dobeson, Caroline, additional, Thirlwell, Christina, additional, Mitchell, Christian, additional, Sng, Christopher, additional, Scrase, Christopher, additional, Jingree, Christopher, additional, Brunner, Clair, additional, Fuller, Claire, additional, Griffin, Clare, additional, Barrington, Craig, additional, Muller, Daniel, additional, Ottaviani, Diego, additional, Gilbert, Duncan, additional, Tacconi, Eliana, additional, Copson, Ellen, additional, Renninson, Emily, additional, Cattell, Emma, additional, Burke, Emma, additional, Smith, Fiona, additional, Holt, Francesca, additional, Soosaipillai, Gehan, additional, Boyce, Hayley, additional, Shaw, Heather, additional, Hollis, Helen, additional, Bowyer, Helen, additional, Anil, Iris, additional, Illingworth, Jack, additional, Gibson, Jack, additional, Bhosle, Jaishree, additional, Best, James, additional, Barrett, Jane, additional, Noble, Jillian, additional, Sacco, Joseph, additional, Chacko, Joseph, additional, Chackathayil, Julia, additional, Banfill, Kathryn, additional, Feeney, Laura, additional, Horsley, Laura, additional, Cammaert, Lauren, additional, Mukherjee, Leena, additional, Eastlake, Leonie, additional, Devereaux, Louise, additional, Melcher, Lucinda, additional, Cook, Lucy, additional, Teng, Mabel, additional, Hewish, Madeleine, additional, Bhattacharyya, Madhumita, additional, Choudhury, Mahbuba, additional, Baxter, Mark, additional, Scott-Brown, Martin, additional, Fittall, Matthew, additional, Tilby, Michael, additional, Rowe, Michael, additional, Alihilali, Mohammed, additional, Galazi, Myria, additional, Yousaf, Nadia, additional, Chopra, Neha, additional, Cox, Nicola, additional, Chan, Olivia, additional, Sheikh, Omar, additional, Ramage, Paul, additional, Greaves, Paul, additional, Leonard, Pauline, additional, Hall, Peter S, additional, Naksukpaiboon, Piangfan, additional, Corrie, Pippa, additional, Peck, Rahul, additional, Sharkey, Rachel, additional, Bolton, Rachel, additional, Sargent, Rebecca, additional, Jyothirmayi, Rema, additional, Goldstein, Robert, additional, Oakes, Roderick, additional, Shotton, Rohan, additional, Kanani, Ruhi, additional, Board, Ruth, additional, Pettengell, Ruth, additional, Claydon, Ryan, additional, Moody, Sam, additional, Massalha, Samah, additional, Kathirgamakarthigeyan, Sangary, additional, Dolly, Saoirse, additional, Derby, Sarah, additional, Lowndes, Sarah, additional, Benafif, Sarah, additional, Eeckelaers, Sarah, additional, Kingdon, Sarah, additional, Ayers, Sarah, additional, Brown, Sean, additional, Ellis, Shawn, additional, Parikh, Shefali, additional, Pugh, Sian, additional, Shamas, Simon, additional, Wyatt, Simon, additional, Grumett, Simon, additional, Lau, Sin, additional, Wong, Yien Ning Sophia, additional, McGrath, Sophie, additional, Cornthwaite, Stephanie, additional, Hibbs, Stephen, additional, Tillet, Tania, additional, Rabbi, Taslima, additional, Robinson, Tim, additional, Roques, Tom, additional, Angelis, Vasileios, additional, Woodcock, Victoria, additional, Brown, Victoria, additional, Peng, YingYing, additional, Drew, Yvette, additional, and Hudson, Zoe, additional

Published
2020
Full Text
View/download PDF

15. Key findings from the UKCCMP cohort of 877 patients with haematological malignancy and COVID‐19: disease control as an important factor relative to recent chemotherapy or anti‐CD20 therapy.

Author

Booth, Stephen, Curley, Helen M., Varnai, Csilla, Arnold, Roland, Lee, Lennard Y. W., Campton, Naomi A., Cook, Gordon, Purshouse, Karin, Aries, James, Innes, Andrew, Cook, Lucy B., Tomkins, Oliver, Oram, Helen S., Tilby, Michael, Kulasekararaj, Austin, Wrench, David, Dolly, Saoirse, Newsom‐Davies, Tom, Pettengell, Ruth, and Gault, Abigail

Subjects
COVID-19, PREVENTIVE medicine, CANCER chemotherapy, ACUTE leukemia, MULTIVARIATE analysis, INFECTION
Abstract

Summary: Patients with haematological malignancies have a high risk of severe infection and death from SARS‐CoV‐2. In this prospective observational study, we investigated the impact of cancer type, disease activity, and treatment in 877 unvaccinated UK patients with SARS‐CoV‐2 infection and active haematological cancer. The primary end‐point was all‐cause mortality. In a multivariate analysis adjusted for age, sex and comorbidities, the highest mortality was in patients with acute leukaemia [odds ratio (OR) = 1·73, 95% confidence interval (CI) 1·1–2·72, P = 0·017] and myeloma (OR 1·3, 95% CI 0·96–1·76, P = 0·08). Having uncontrolled cancer (newly diagnosed awaiting treatment as well as relapsed or progressive disease) was associated with increased mortality risk (OR = 2·45, 95% CI 1·09–5·5, P = 0·03), as was receiving second or beyond line of treatment (OR = 1·7, 95% CI 1·08–2·67, P = 0·023). We found no association between recent cytotoxic chemotherapy or anti‐CD19/anti‐CD20 treatment and increased risk of death within the limitations of the cohort size. Therefore, disease control is an important factor predicting mortality in the context of SARS‐CoV‐2 infection alongside the possible risks of therapies such as cytotoxic treatment or anti‐CD19/anti‐CD20 treatments. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results