157 results on '"Gaul, Christoph"'
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2. Supplementary Table S2 from Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode Dependent
3. Data from Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode Dependent
4. Supplementary Figures, Methods, and References from Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode Dependent
5. Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia
6. CHZ868, a Type II JAK2 Inhibitor, Reverses Type I JAK Inhibitor Persistence and Demonstrates Efficacy in Myeloproliferative Neoplasms
7. Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts
8. Design, synthesis, and evaluation of matrix metalloprotease inhibitors bearing cyclopropane-derived peptidomimetics as P1' and P2' replacements
9. 4-isopropyl-3-(methylthiomethyl)-5,5-diphenyloxazolidin-2-one: a chiral formyl anion equivalent for enantioselective preparations of 1,2-diols, 2-amino alcohols,2-hydroxy esters, and 4-hydroxy-2-alkenoates
10. Evolution of Novartis’ Small Molecule Screening Deck Design
11. Abstract 1770: A new DOT1L inhibitor with in vivo activity in mouse models of MLL-translocated leukemia
12. DOT1L inhibition is lethal for multiple myeloma due to perturbation of the endoplasmic reticulum stress pathway
13. New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse
14. Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach
15. Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region
16. The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis
17. Discovery of potent cell migration inhibitors through total synthesis: lessons from structure-activity studies of (+)-migrastatin
18. Identification of Orally Available Naphthyridine Protein Kinase D Inhibitors
19. Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket
20. Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach
21. 2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes
22. The total synthesis of (+)-migrastatin
23. Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors
24. 2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors
25. Confirmation of the structures of synthetic derivatives of migrastatin in the light of recently disclosed crystallographically based claims
26. Type II Inhibition of JAK2 with NVP-CHZ868 Reverses Type I JAK Inhibitor Persistence and Demonstrates Increased Efficacy in MPN Models
27. Type II JAK2 Inhibitor NVP-CHZ868 Is Active in Vivo Against JAK2-Dependent B-Cell Acute Lymphoblastic Leukemias (B-ALLs)
28. Modulation of Activation-Loop Phosphorylation by JAK Inhibitors Is Binding Mode Dependent
29. Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition
30. Genetic Resistance to JAK2 Enzymatic Inhibitors Is Overcome by HSP90 Inhibition
31. Identification of Orally Available Naphthyridine Protein Kinase D Inhibitors
32. ChemInform Abstract: Metallations and Reactions with Electrophiles of 4-Isopropyl-5,5-diphenyloxazolidin-2-one (DIOZ) with N-Allyl and N-Propargyl Substituents: Chiral Homoenolate Reagents.
33. Applications of the Chiral Auxiliaries DIOZ and TRIOZ for Conjugate Additions and Comparison with Other Auxiliaries
34. En Route to the Total Synthesis of Tashironin: The Exercise of Stereochemical Control by a Methyl Group in Mediating Remote Cyclization Reactions.
35. En route to the total synthesis of tashironin: on the exercise of stereochemical control by a methyl group in mediating remote cyclization reactions
36. Discovery of Potent Cell Migration Inhibitors through Total Synthesis: Lessons from Structure−Activity Studies of (+)-Migrastatin
37. The Total Synthesis of (+)-Migrastatin.
38. Effects of Temperature and Concentration in Some Ring Closing Metathesis Reactions.
39. Synthesis of the Macrolide Core (I) of Migrastatin (II).
40. Synthesis of the macrolide core of migrastatin
41. ChemInform Abstract: Conjugate Addition of Lithiated (S)‐4‐Isopropyl‐3‐[(methylthio)methyl]‐5,5‐diphenyloxazolidin‐2‐one to Cinnamoyl Derivatives: Preparation of Enantiomerically Pure 1,4‐Diols.
42. Crystal Structures– AManifesto for the Superiority of the Valine-Derived 5,5-Diphenyloxazolidinone as an Auxiliary in Enantioselective Organic Synthesis
43. Metallations and Reactions with Electrophiles of 4-Isopropyl-5,5-diphenyloxazolidin-2-one (DIOZ) with N-Allyl and N-Propargyl Substituents: Chiral Homoenolate Reagents
44. Conjugate Addition of Lithiated (S)-4-Isopropyl-3- [(methylthio)methyl]-5,5-diphenyloxazolidin-2-one to Cinnamoyl Derivatives: Preparation of Enantiomerically Pure 1,4-Diols
45. From Synthetic Methods to γ-Peptides – From Chemistry to Biology
46. Computational, ReactIR-, and NMR-Spectroscopic Investigations on the Chiral Formyl Anion EquivalentN-(α-Lithiomethylthiomethyl)-4-isopropyl-5,5-diphenyloxazolidin-2-one and Related Compounds
47. ChemInform Abstract: Lithiated 4‐Isopropyl‐3‐(methylthiomethyl)‐5,5‐diphenyloxazolidin‐2‐one: A Chiral Formyl Anion Equivalent for Enantioselective Preparations of 1,2‐Diols, 2‐Amino Alcohols, 2‐Hydroxy Esters, and 4‐Hydroxy‐2‐alkenoates.
48. Lithiated 4-Isopropyl-3-(methylthiomethyl)-5,5-diphenyloxazolidin-2-one: A Chiral Formyl Anion Equivalent for Enantioselective Preparations of 1,2-Diols, 2-Amino Alcohols, 2-Hydroxy Esters, and 4-Hydroxy-2-alkenoates
49. ChemInform Abstract: A Valine‐Derived Lithiated 3‐Methylthiomethyl‐1,3‐oxazolidin‐2‐one for Enantioselective Nucleophilic Hydroxymethylation, Formylation, and Alkoxycarbonylation of Aldehydes.
50. A Valine-Derived Lithiated 3-Methylthiomethyl-1,3-oxazolidin-2-one for Enantioselective Nucleophilic Hydroxymethylation, Formylation, and Alkoxycarbonylation of Aldehydes
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