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249 results on '"Gaudry, M."'

2. Resonant Raman Scattering by quadrupolar vibrations of Ni-Ag Core-shell Nanoparticles

Author

Portales, H., Saviot, L., Duval, E., Gaudry, M., Cottancin, E., Pellarin, M., Lerme, J., and Broyer, M.

Subjects
Condensed Matter
Abstract

Low-frequency Raman scattering experiments have been performed on thin films consisting of nickel-silver composite nanoparticles embedded in alumina matrix. It is observed that the Raman scattering by the quadrupolar modes, strongly enhanced when the light excitation is resonant with the surface dipolar excitation, is mainly governed by the silver electron contribution to the plasmon excitation. The Raman results are in agreement with a core-shell structure of the nanoparticles, the silver shell being loosely bonded to the nickel core., Comment: 3 figures. To be published in Phys. Rev. B

Published
2002
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11. Constitutive Activation of RAS/MAPK Pathway Cooperates with Trisomy 21 and Is Therapeutically Exploitable in Down Syndrome B-cell Leukemia

Author

Laurent, A.P., Siret, A., Ignacimouttou, C., Panchal, K., Diop, M., Jenni, S., Tsai, Y.C., Roos-Weil, D., Aid, Z., Prade, N., Lagarde, S., Plassard, D., Pierron, G., Daudigeos, E., Lecluse, Y., Droin, N., Bornhauser, B.C., Cheung, Laurence, Crispino, J.D., Gaudry, M., Bernard, O.A., Macintyre, E., Barin Bonnigal, C., Kotecha, Rishi, Geoerger, B., Ballerini, P., Bourquin, J.P., Delabesse, E., Mercher, T., Malinge, S., Laurent, A.P., Siret, A., Ignacimouttou, C., Panchal, K., Diop, M., Jenni, S., Tsai, Y.C., Roos-Weil, D., Aid, Z., Prade, N., Lagarde, S., Plassard, D., Pierron, G., Daudigeos, E., Lecluse, Y., Droin, N., Bornhauser, B.C., Cheung, Laurence, Crispino, J.D., Gaudry, M., Bernard, O.A., Macintyre, E., Barin Bonnigal, C., Kotecha, Rishi, Geoerger, B., Ballerini, P., Bourquin, J.P., Delabesse, E., Mercher, T., and Malinge, S.

Abstract

©2020 American Association for Cancer Research. PURPOSE: Children with Down syndrome (constitutive trisomy 21) that develop acute lymphoblastic leukemia (DS-ALL) have a 3-fold increased likelihood of treatment-related mortality coupled with a higher cumulative incidence of relapse, compared with other children with B-cell acute lymphoblastic leukemia (B-ALL). This highlights the lack of suitable treatment for Down syndrome children with B-ALL. EXPERIMENTAL DESIGN: To facilitate the translation of new therapeutic agents into clinical trials, we built the first preclinical cohort of patient-derived xenograft (PDX) models of DS-ALL, comprehensively characterized at the genetic and transcriptomic levels, and have proven its suitability for preclinical studies by assessing the efficacy of drug combination between the MEK inhibitor trametinib and conventional chemotherapy agents. RESULTS: Whole-exome and RNA-sequencing experiments revealed a high incidence of somatic alterations leading to RAS/MAPK pathway activation in our cohort of DS-ALL, as well as in other pediatric B-ALL presenting somatic gain of the chromosome 21 (B-ALL+21). In murine and human B-cell precursors, activated KRASG12D functionally cooperates with trisomy 21 to deregulate transcriptional networks that promote increased proliferation and self renewal, as well as B-cell differentiation blockade. Moreover, we revealed that inhibition of RAS/MAPK pathway activation using the MEK1/2 inhibitor trametinib decreased leukemia burden in several PDX models of B-ALL+21, and enhanced survival of DS-ALL PDX in combination with conventional chemotherapy agents such as vincristine. CONCLUSIONS: Altogether, using novel and suitable PDX models, this study indicates that RAS/MAPK pathway inhibition represents a promising strategy to improve the outcome of Down syndrome children with B-cell precursor leukemia.

Published
2020

16. Ontogenic changes in hematopoietic hierarchy determine pediatric specificity and disease phenotype in fusion oncogene– driven myeloid leukemia

Author

Lopez, C. K., Noguera, E., Stavropoulou, V., Robert, E., Aid, Z., Ballerini, P., Bilhou-Nabera, C., Lapillonne, H., Boudia, F., Thirant, C., Fagnan, A., Arcangeli, M. -L., Kinston, S. J., Diop, M., Job, B., Lecluse, Y., Brunet, E., Babin, L., Villeval, J. L., Delabesse, E., Peters, A. H. F. M., Vainchenker, W., Gaudry, M., Masetti, R., Locatelli, Franco, Malinge, S., Nerlov, C., Droin, N., Lobry, C., Godin, I., Bernard, O. A., Gottgens, B., Petit, A., Pflumio, F., Schwaller, J., Mercher, T., Locatelli F. (ORCID:0000-0002-7976-3654), Lopez, C. K., Noguera, E., Stavropoulou, V., Robert, E., Aid, Z., Ballerini, P., Bilhou-Nabera, C., Lapillonne, H., Boudia, F., Thirant, C., Fagnan, A., Arcangeli, M. -L., Kinston, S. J., Diop, M., Job, B., Lecluse, Y., Brunet, E., Babin, L., Villeval, J. L., Delabesse, E., Peters, A. H. F. M., Vainchenker, W., Gaudry, M., Masetti, R., Locatelli, Franco, Malinge, S., Nerlov, C., Droin, N., Lobry, C., Godin, I., Bernard, O. A., Gottgens, B., Petit, A., Pflumio, F., Schwaller, J., Mercher, T., and Locatelli F. (ORCID:0000-0002-7976-3654)

Abstract

Fusion oncogenes are prevalent in several pediatric cancers, yet little is known about the specific associations between age and phenotype. We observed that fusion oncogenes, such as ETO2–GLIS2, are associated with acute megakaryoblastic or other myeloid leukemia subtypes in an age-dependent manner. Analysis of a novel inducible transgenic mouse model showed that ETO2–GLIS2 expression in fetal hematopoietic stem cells induced rapid megakaryoblastic leukemia whereas expression in adult bone marrow hematopoietic stem cells resulted in a shift toward myeloid transformation with a strikingly delayed in vivo leukemogenic potential. Chromatin accessibility and single-cell transcriptome analyses indicate ontogeny-dependent intrinsic and ETO2–GLIS2-induced differences in the activities of key transcription factors, including ERG, SPI1, GATA1, and CEBPA. Importantly, switching off the fusion oncogene restored terminal differentiation of the leukemic blasts. Together, these data show that aggressiveness and phenotypes in pediatric acute myeloid leukemia result from an ontogeny-related differential susceptibility to transformation by fusion oncogenes. SIGNIFICANCE: This work demonstrates that the clinical phenotype of pediatric acute myeloid leukemia is determined by ontogeny-dependent susceptibility for transformation by oncogenic fusion genes. The phenotype is maintained by potentially reversible alteration of key transcription factors, indicating that targeting of the fusions may overcome the differentiation blockage and revert the leukemic state.

Published
2019

21. Dot

Author

Laoust-Chantreaux, G., Laoust, E., Berque, J., Gaudry, M., E.B., and Claudot-Hawad, H.

Subjects
Famille, Ethnologie
Abstract

En Kabylie (d'après G. Laoust-Chantreaux) Le calcul qui permet de fixer le montant de la dot, en Kabylie, obéit à un véritable rituel bien décrit par G. Laoust-Chantereaux pour la période qui précéda la deuxième Guerre mondiale. Bien qu’il ait été déjà arrêté entre les deux familles, le montant doit être débattu devant témoins après un repas offert chez le père de la jeune fille mais aux frais des parents du jeune homme. Le déroulement de la cérémonie est invariable : le père de la jeune fill...

Published
2012

28. Electron-Phonon Scattering in Metal Clusters

Author

Arbouet, A., primary, Voisin, C., additional, Christofilos, D., additional, Langot, P., additional, Fatti, N. Del, additional, Vallée, F., additional, Lermé, J., additional, Celep, G., additional, Cottancin, E., additional, Gaudry, M., additional, Pellarin, M., additional, Broyer, M., additional, Maillard, M., additional, Pileni, M. P., additional, and Treguer, M., additional

Published
2003
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49. Size and concentration effects in the optical properties of alloyed ( Au x Ag 1 - x ) n and core-shell ( Ni x Ag 1 - x ) n embedded clusters.

Author

Gaudry, M., Lermé, J., Cottancin, E., Pellarin, M., Prével, B., Treilleux, M., Mélinon, P., Rousset, J.-L., and Broyer, M.

Abstract

Optical properties of mixed clusters (AuxAg 1 - x ) n and (NixAg 1 - x ) n, produced by laser vaporization and embedded in an alumina matrix, are reported. The size effects are investigated for different concentrations ( x = 0.25, 0.5 and 0.75) in the diameter range 2-4 nm. For alloyed clusters (AuxAg 1 - x ) n of a given size an almost linear evolution of the surface plasmon frequency ω s with the concentration is observed (between those of pure gold and pure silver clusters). Moreover the blue-shift and the damping of the resonance with decreasing size is all the more important as the gold concentration in the particles increases. Such results are in agreement with theoretical calculations carried out in the frame of the time-dependent local-density-approximation (TDLDA) including an inner skin of ineffective screening and the porosity of the matrix. The optical response of (NixAg 1 - x ) n clusters exhibits a surface plasmon resonance in the same spectral range as the one observed for pure silver clusters, but considerably damped and broadened. For a given mean cluster size 3.0 nm, a blue-shift of the resonance is observed when increasing the nickel concentration (between x = 0.25 and x = 0.75). The results are in good qualitative agreement with classical predictions in the dipolar approximation, assuming a core-shell geometry. [ABSTRACT FROM AUTHOR]

Published
2001
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