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Your search keyword '"Gaudiano, Maria Cristina"' showing total 37 results
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37 results on '"Gaudiano, Maria Cristina"'

7. A screening method for the quantitative determination of selective androgen receptor modulators (SARMs) in capsules by high resolution 19F- and 1H-NMR spectroscopyElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d4ay00188e

Author

Maccelli, Alessandro, Borioni, Anna, Aureli, Federica, Gaudiano, Maria Cristina, Manna, Livia, and Raimondo, Mariangela

Abstract

A new method for rapid determination of the content of selective androgenic receptor modulators (SARMs) andarine, cardarine, ligandrol, ostarine and S-23 in capsules by 1H- and 19F-high resolution nuclear magnetic resonance spectroscopy was described and validated. Specificity, linearity, accuracy, precision, detection and quantification limits were considered as validation parameters. Full 1H-, 13C- and 19F-NMR structural assignment of the SARMs is provided as a tool for self-standing identification without a reference standard. Amounts of 7–15 mg of SARMs/capsule were detected in different products with an intermediate precision of 0.8–1.7% in 4 to 20 minutes of analysis time. The validation results and rapidity of analysis confirm the applicability of the method for large-scale screening. The statistical analysis of the results from 19F- and 1H-quantitative NMR showed that both approaches were equally effective, thus expanding the potential use of the methodology to non-fluorinated SARMs. At present, no SARM has been approved for human consumption; however, SARMs are actually used by bodybuilders and recreational athletes, who purchase them even though the risk–benefit ratio of these molecules has not been definitively established.

Published
2024
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36. A screening method for the quantitative determination of selective androgen receptor modulators (SARMs) in capsules by high resolution 19 F- and 1 H-NMR spectroscopy.

Author

Maccelli A, Borioni A, Aureli F, Gaudiano MC, Manna L, and Raimondo M

Subjects
Humans, Androgens chemistry, Androgen Antagonists, Magnetic Resonance Spectroscopy, Receptors, Androgen, Anabolic Agents chemistry
Abstract

A new method for rapid determination of the content of selective androgenic receptor modulators (SARMs) andarine, cardarine, ligandrol, ostarine and S-23 in capsules by 1 H- and 19 F-high resolution nuclear magnetic resonance spectroscopy was described and validated. Specificity, linearity, accuracy, precision, detection and quantification limits were considered as validation parameters. Full 1 H-, 13 C- and 19 F-NMR structural assignment of the SARMs is provided as a tool for self-standing identification without a reference standard. Amounts of 7-15 mg of SARMs/capsule were detected in different products with an intermediate precision of 0.8-1.7% in 4 to 20 minutes of analysis time. The validation results and rapidity of analysis confirm the applicability of the method for large-scale screening. The statistical analysis of the results from 19 F- and 1 H-quantitative NMR showed that both approaches were equally effective, thus expanding the potential use of the methodology to non-fluorinated SARMs. At present, no SARM has been approved for human consumption; however, SARMs are actually used by bodybuilders and recreational athletes, who purchase them even though the risk-benefit ratio of these molecules has not been definitively established.

Published
2024
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37. A NIR, 1 H-NMR, LC-MS and chemometrics pilot study on the origin of carvedilol drug substances: a tool for discovering falsified active pharmaceutical ingredients.

Author

Raimondo M, Borioni A, Prestinaci F, Sestili I, and Gaudiano MC

Subjects
Carvedilol, Chromatography, Liquid, Magnetic Resonance Spectroscopy methods, Pharmaceutical Preparations, Pilot Projects, Proton Magnetic Resonance Spectroscopy, Chemometrics, Tandem Mass Spectrometry
Abstract

Falsification of drugs, entailing the use of drug substances from unknown unapproved suppliers, is one of the main concerns for the quality of medicines. Therefore, traceability of active ingredients represents an effective tool to fight the illegal trade of medicinal products. In this view, the present pilot study explores the profile of carvedilol active ingredients and possible differences related to the origin. Sixteen samples were examined by near-infrared spectroscopy (NIR), proton nuclear magnetic resonance ( 1 H-NMR spectrometry) and liquid chromatography mass spectrometry (LC-MS) Q-TOF and the data were analysed by principal component analysis (PCA), cluster analysis and PLSDA discriminant analysis. The results evidenced that the combined information from the three techniques gave good classification of the samples neatly distinguishing the APIs from European countries from the APIs manufactured out of Europe. In particular, NIR spectroscopy provided effective separation between European and non-European manufacturers and 1 H-NMR or LC-MS added specific information related to the separation. Concerning LC-MS Q-TOF, the analysis of multiple isobaric peaks proved to be highly predictive of the drug substance origin and emerged as a promising tool in the field of medicine traceability.

Published
2022
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