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4. Economic income and survival in patients affected by glioblastoma: A systematic review and meta-analysis.

Author

Nunno, Vincenzo Di, Gatto, Lidia, Aprile, Marta, Bartolini, Stefania, Tosoni, Alicia, and Franceschi, Enrico

Subjects
*RANDOM effects model, *OVERALL survival, *HEALTH equity, *SOCIOECONOMIC factors, *GLIOBLASTOMA multiforme
Abstract

Background Within socioeconomic variables, economic income has been associated with the prognosis of patients with glioblastoma. However, studies investigating this issue provided conflicting results. Methods We carried out a systematic review and meta-analysis of studies investigating the correlation between economic income and survival in patients with glioblastoma. The inverse variance technique for hazard ratio (HR) assessment has been employed in reporting the random effect model. Results We included 12 studies for a total of 143 303 GBM patients (67 463 with high economic income, and 25 679 with low economic income). In the overall analysis, lower economic income resulted in poorer survival (pooled HR 1.09, 95% CI: 1.02–1.17, I2 = 64%). Variables like the type of Health Care System (public, private, or mixed) and the time in which patients have been treated (pre or post-EORTC-NCIC trial 22981/26981, CE.3 protocol advent) did not modify survival on pooled analysis. Conclusions Economic conditions and income influence the prognosis of patients with glioblastoma. A better understanding of the modifiable barriers leading to treatment disparities in more disadvantaged patients is warranted to make equal oncological care. [ABSTRACT FROM AUTHOR]

Published
2024
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23. The Biological and Clinical Role of the Telomerase Reverse Transcriptase Gene in Glioblastoma: A Potential Therapeutic Target?

Author

Di Nunno, Vincenzo, Aprile, Marta, Bartolini, Stefania, Gatto, Lidia, Tosoni, Alicia, Ranieri, Lucia, De Biase, Dario, Asioli, Sofia, and Franceschi, Enrico

Subjects
TELOMERASE reverse transcriptase, TELOMERASE, CENTRAL nervous system tumors, REVERSE transcriptase, GLIOBLASTOMA multiforme, BRAIN tumors
Abstract

Glioblastoma IDH-wildtype represents the most lethal and frequent primary tumor of the central nervous system. Thanks to important scientific efforts, we can now investigate its deep genomic assessment, elucidating mutated genes and altered biological mechanisms in addition to its clinical aggressiveness. The telomerase reverse transcriptase gene (TERT) is the most frequently altered gene in solid tumors, including brain tumors and GBM IDH-wildtype. In particular, it can be observed in approximately 80–90% of GBM IDH-wildtype cases. Its clonal distribution on almost all cancer cells makes this gene an optimal target. However, the research of effective TERT inhibitors is complicated by several biological and clinical obstacles which can be only partially surmounted. Very recently, novel immunological approaches leading to TERT inhibition have been investigated, offering the potential to develop an effective target for this altered protein. Here, we perform a narrative review investigating the biological role of TERT alterations on glioblastoma and the principal obstacles associated with TERT inhibitions in this population. Moreover, we discuss possible combination treatment strategies to overcome these limitations. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Data from Genome-Wide Analysis Identifies MEN1 and MAX Mutations and a Neuroendocrine-Like Molecular Heterogeneity in Quadruple WT GIST

Author

Pantaleo, Maria A., primary, Urbini, Milena, primary, Indio, Valentina, primary, Ravegnini, Gloria, primary, Nannini, Margherita, primary, De Luca, Matilde, primary, Tarantino, Giuseppe, primary, Angelini, Sabrina, primary, Gronchi, Alessandro, primary, Vincenzi, Bruno, primary, Grignani, Giovanni, primary, Colombo, Chiara, primary, Fumagalli, Elena, primary, Gatto, Lidia, primary, Saponara, Maristella, primary, Ianni, Manuela, primary, Paterini, Paola, primary, Santini, Donatella, primary, Pirini, M. Giulia, primary, Ceccarelli, Claudio, primary, Altimari, Annalisa, primary, Gruppioni, Elisa, primary, Renne, Salvatore L., primary, Collini, Paola, primary, Stacchiotti, Silvia, primary, Brandi, Giovanni, primary, Casali, Paolo G., primary, Pinna, Antonio D., primary, Astolfi, Annalisa, primary, and Biasco, Guido, primary

Published
2023
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25. Revised supplementary Figure 1 from Genome-Wide Analysis Identifies MEN1 and MAX Mutations and a Neuroendocrine-Like Molecular Heterogeneity in Quadruple WT GIST

Author

Pantaleo, Maria A., primary, Urbini, Milena, primary, Indio, Valentina, primary, Ravegnini, Gloria, primary, Nannini, Margherita, primary, De Luca, Matilde, primary, Tarantino, Giuseppe, primary, Angelini, Sabrina, primary, Gronchi, Alessandro, primary, Vincenzi, Bruno, primary, Grignani, Giovanni, primary, Colombo, Chiara, primary, Fumagalli, Elena, primary, Gatto, Lidia, primary, Saponara, Maristella, primary, Ianni, Manuela, primary, Paterini, Paola, primary, Santini, Donatella, primary, Pirini, M. Giulia, primary, Ceccarelli, Claudio, primary, Altimari, Annalisa, primary, Gruppioni, Elisa, primary, Renne, Salvatore L., primary, Collini, Paola, primary, Stacchiotti, Silvia, primary, Brandi, Giovanni, primary, Casali, Paolo G., primary, Pinna, Antonio D., primary, Astolfi, Annalisa, primary, and Biasco, Guido, primary

Published
2023
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26. Revised supplementary Figure 2 from Genome-Wide Analysis Identifies MEN1 and MAX Mutations and a Neuroendocrine-Like Molecular Heterogeneity in Quadruple WT GIST

Author

Pantaleo, Maria A., primary, Urbini, Milena, primary, Indio, Valentina, primary, Ravegnini, Gloria, primary, Nannini, Margherita, primary, De Luca, Matilde, primary, Tarantino, Giuseppe, primary, Angelini, Sabrina, primary, Gronchi, Alessandro, primary, Vincenzi, Bruno, primary, Grignani, Giovanni, primary, Colombo, Chiara, primary, Fumagalli, Elena, primary, Gatto, Lidia, primary, Saponara, Maristella, primary, Ianni, Manuela, primary, Paterini, Paola, primary, Santini, Donatella, primary, Pirini, M. Giulia, primary, Ceccarelli, Claudio, primary, Altimari, Annalisa, primary, Gruppioni, Elisa, primary, Renne, Salvatore L., primary, Collini, Paola, primary, Stacchiotti, Silvia, primary, Brandi, Giovanni, primary, Casali, Paolo G., primary, Pinna, Antonio D., primary, Astolfi, Annalisa, primary, and Biasco, Guido, primary

Published
2023
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27. Revised supplementary Table 1 from Genome-Wide Analysis Identifies MEN1 and MAX Mutations and a Neuroendocrine-Like Molecular Heterogeneity in Quadruple WT GIST

Author

Pantaleo, Maria A., primary, Urbini, Milena, primary, Indio, Valentina, primary, Ravegnini, Gloria, primary, Nannini, Margherita, primary, De Luca, Matilde, primary, Tarantino, Giuseppe, primary, Angelini, Sabrina, primary, Gronchi, Alessandro, primary, Vincenzi, Bruno, primary, Grignani, Giovanni, primary, Colombo, Chiara, primary, Fumagalli, Elena, primary, Gatto, Lidia, primary, Saponara, Maristella, primary, Ianni, Manuela, primary, Paterini, Paola, primary, Santini, Donatella, primary, Pirini, M. Giulia, primary, Ceccarelli, Claudio, primary, Altimari, Annalisa, primary, Gruppioni, Elisa, primary, Renne, Salvatore L., primary, Collini, Paola, primary, Stacchiotti, Silvia, primary, Brandi, Giovanni, primary, Casali, Paolo G., primary, Pinna, Antonio D., primary, Astolfi, Annalisa, primary, and Biasco, Guido, primary

Published
2023
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28. Revised supplementary Table 4 from Genome-Wide Analysis Identifies MEN1 and MAX Mutations and a Neuroendocrine-Like Molecular Heterogeneity in Quadruple WT GIST

Author

Pantaleo, Maria A., primary, Urbini, Milena, primary, Indio, Valentina, primary, Ravegnini, Gloria, primary, Nannini, Margherita, primary, De Luca, Matilde, primary, Tarantino, Giuseppe, primary, Angelini, Sabrina, primary, Gronchi, Alessandro, primary, Vincenzi, Bruno, primary, Grignani, Giovanni, primary, Colombo, Chiara, primary, Fumagalli, Elena, primary, Gatto, Lidia, primary, Saponara, Maristella, primary, Ianni, Manuela, primary, Paterini, Paola, primary, Santini, Donatella, primary, Pirini, M. Giulia, primary, Ceccarelli, Claudio, primary, Altimari, Annalisa, primary, Gruppioni, Elisa, primary, Renne, Salvatore L., primary, Collini, Paola, primary, Stacchiotti, Silvia, primary, Brandi, Giovanni, primary, Casali, Paolo G., primary, Pinna, Antonio D., primary, Astolfi, Annalisa, primary, and Biasco, Guido, primary

Published
2023
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29. Revised supplementary Table 2 from Genome-Wide Analysis Identifies MEN1 and MAX Mutations and a Neuroendocrine-Like Molecular Heterogeneity in Quadruple WT GIST

Author

Pantaleo, Maria A., primary, Urbini, Milena, primary, Indio, Valentina, primary, Ravegnini, Gloria, primary, Nannini, Margherita, primary, De Luca, Matilde, primary, Tarantino, Giuseppe, primary, Angelini, Sabrina, primary, Gronchi, Alessandro, primary, Vincenzi, Bruno, primary, Grignani, Giovanni, primary, Colombo, Chiara, primary, Fumagalli, Elena, primary, Gatto, Lidia, primary, Saponara, Maristella, primary, Ianni, Manuela, primary, Paterini, Paola, primary, Santini, Donatella, primary, Pirini, M. Giulia, primary, Ceccarelli, Claudio, primary, Altimari, Annalisa, primary, Gruppioni, Elisa, primary, Renne, Salvatore L., primary, Collini, Paola, primary, Stacchiotti, Silvia, primary, Brandi, Giovanni, primary, Casali, Paolo G., primary, Pinna, Antonio D., primary, Astolfi, Annalisa, primary, and Biasco, Guido, primary

Published
2023
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30. Revised supplementary Table 3 from Genome-Wide Analysis Identifies MEN1 and MAX Mutations and a Neuroendocrine-Like Molecular Heterogeneity in Quadruple WT GIST

Author

Pantaleo, Maria A., primary, Urbini, Milena, primary, Indio, Valentina, primary, Ravegnini, Gloria, primary, Nannini, Margherita, primary, De Luca, Matilde, primary, Tarantino, Giuseppe, primary, Angelini, Sabrina, primary, Gronchi, Alessandro, primary, Vincenzi, Bruno, primary, Grignani, Giovanni, primary, Colombo, Chiara, primary, Fumagalli, Elena, primary, Gatto, Lidia, primary, Saponara, Maristella, primary, Ianni, Manuela, primary, Paterini, Paola, primary, Santini, Donatella, primary, Pirini, M. Giulia, primary, Ceccarelli, Claudio, primary, Altimari, Annalisa, primary, Gruppioni, Elisa, primary, Renne, Salvatore L., primary, Collini, Paola, primary, Stacchiotti, Silvia, primary, Brandi, Giovanni, primary, Casali, Paolo G., primary, Pinna, Antonio D., primary, Astolfi, Annalisa, primary, and Biasco, Guido, primary

Published
2023
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32. Molecular modelling evaluation of exon 18 His845_Asn848delinsPro PDGFRα mutation in a metastatic GIST patient responding to imatinib

Author

Nannini, Margherita, Tarantino, Giuseppe, Indio, Valentina, Ravegnini, Gloria, Astolfi, Annalisa, Urbini, Milena, De Leo, Antonio, Santini, Donatella, Ceccarelli, Claudio, Gruppioni, Elisa, Altimari, Annalisa, Castellucci, Paolo, Fanti, Stefano, Di Scioscio, Valerio, Saponara, Maristella, Gatto, Lidia, Pession, Andrea, Martelli, Pier Luigi, Casadio, Rita, and Pantaleo, Maria Abbondanza

Published
2019
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37. An exploratory association of polymorphisms in angiogenesis-related genes with susceptibility, clinical response and toxicity in gastrointestinal stromal tumors receiving sunitinib after imatinib failure

Author

Ravegnini, Gloria, Nannini, Margherita, Zenesini, Corrado, Simeon, Vittorio, Sammarini, Giulia, Urbini, Milena, Gatto, Lidia, Saponara, Maristella, Biasco, Guido, Pantaleo, Maria A., Venturoli, Nicola, Hrelia, Patrizia, and Angelini, Sabrina

Published
2017
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41. Adult Medulloblastoma: Updates on Current Management and Future Perspectives

Author

Franceschi, Enrico, Giannini, Caterina, Furtner, Julia, Pajtler, Kristian W., Asioli, Sofia, Guzman, Raphael, Seidel, Clemens, Gatto, Lidia, Hau, Peter, Franceschi, Enrico, Giannini, Caterina, Furtner, Julia, Pajtler, Kristian W., Asioli, Sofia, Guzman, Raphael, Seidel, Clemens, Gatto, Lidia, and Hau, Peter

Abstract

Medulloblastoma (MB) is a malignant embryonal tumor of the posterior fossa belonging to the family of primitive neuro-ectodermic tumors (PNET). MB generally occurs in pediatric age, but in 14–30% of cases, it affects the adults, mostly below the age of 40, with an incidence of 0.6 per million per year, representing about 0.4–1% of tumors of the nervous system in adults. Unlike pediatric MB, robust prospective trials are scarce for the post-puberal population, due to the low incidence of MB in adolescent and young adults. Thus, current MB treatments for older patients are largely extrapolated from the pediatric experience, but the transferability and applicability of these paradigms to adults remain an open question. Adult MB is distinct from MB in children from a molecular and clinical perspective. Here, we review the management of adult MB, reporting the recent published literature focusing on the effectiveness of upfront chemotherapy, the development of targeted therapies, and the potential role of a reduced dose of radiotherapy in treating this disease.

Published
2022

48. How to treat histone 3 altered gliomas: molecular landscape and therapeutic developments.

Author

Di Nunno, Vincenzo, Franceschi, Enrico, Gatto, Lidia, Tosoni, Alicia, Bartolini, Stefania, and Brandes, Alba Ariela

Subjects
GLIOMAS, THERAPEUTICS, TUMOR treatment, MOLECULAR pathology, DRUG target
Abstract

Diffuse midline gliomas (DMG) and diffuse hemispheric glioma (DHG) are both rare tumors characterized and recognized for specific alterations of histone 3 including H3K27 (DMG) and H3G34 (DHG). Despite these tumors arising from alterations of the same gene their clinical, radiological, and molecular behaviors strongly diverge, requiring a personalized therapeutic approach. We performed a review on Medline/PudMed aiming to search papers relative to prospective trials, retrospective studies, case series, and case reports of interest in order to investigate current knowledge toward the main clinical and molecular characteristics, radiology, and diagnosis, loco-regional and systemic treatments of these tumors. Moreover, we also evaluated the novel treatments under investigation. Thanks to an increased knowledge of the genomic landscape of these rare tumors, there are novels promising therapeutic targets for these malignancies. However, the majority of available trials allowed enrollment only in DMG, while few studies are focused on or allow the inclusion of DHG patients. [ABSTRACT FROM AUTHOR]

Published
2023
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