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38 results on '"Gati, Irith"'

5. Sustained release varnish containing chlorhexidine for prevention of Streptococcus mutansbiofilm formation on voice prosthesis surface: an in vitro study

Author

Gross, Menachem, Ashqar, Fadi, Sionov, Ronit Vogt, Friedman, Michael, Eliashar, Ron, Zaks, Batya, Gati, Irith, Duanis-Assaf, Danielle, Feldman, Mark, and Steinberg, Doron

Abstract

Objectives: In this study, we aimed to develop a novel, sustained release varnish (SRV) for voice prostheses (VP) releasing chlorhexidine (CHX), for the prevention of biofilm formation caused by the common oral bacteria Streptococcus mutanson VP surfaces. Methods: This study was performed in an in vitro model as a step towards future in vivo trials. VPs were coated with a SRV containing CHX (SRV-CHX) or SRV alone (placebo-SRV) that were daily exposed to S. mutans. The polymeric materials of SRV were composed of ethylcellulose and PEG-400. Biofilm formation was assessed by DNA quantification (qPCR), crystal violet staining, confocal laser scanning microscopy (CLSM), scanning electron microscopy (SEM), and kinetics experiments. Results: The amount of DNA in the biofilms formed by S. mutanson VP surfaces coated once with SRV-CHX (1.024 ± 0.218 ng DNA/piece) was 58.5 ± 8.8% lower than that of placebo-SRV-coated VPs (2.465 ± 0.198 ng DNA/piece) after a 48-h exposure to S. mutans(p= 0.038). Reduced biofilm mass on SRV-CHX-coated VPs was visually confirmed by CLSM and SEM. CV staining of SRV-CHX single-coated VPs that have been exposed to S. mutansnine times showed a 98.1 ± 0.2% reduction in biofilm mass compared to placebo-SRV-coated VPs (p= 0.003). Kinetic experiments revealed that SRV-CHX triple-coated VPs could delay bacterial growth for 23 days. Conclusions: Coating VPs with SRV-CHX has an inhibitory effect on biofilm formation and prevents bacterial growth in their vicinities. This study is a proof-of-principle that paves the way for developing new clinical means for reducing both VPs’ bacterial biofilm formation and device failure.

Published
2024
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18. Additional file 1: of Efficacy and potential use of novel sustained release fillers as intracanal medicaments against Enterococcus faecalis biofilm in vitro

Author

Funk, Bernhard, Kirmayer, David, Sharonit Sahar-Heft, Gati, Irith, Friedman, Michael, and Steinberg, Doron

Subjects
genetic structures, embryonic structures, cardiovascular system, technology, industry, and agriculture, macromolecular substances
Abstract

Preparation and drug release of SRF-CPC. The file contains a detailed preparation procedure of the SRF, and the release of CPC measurements. (DOCX 13 kb)

Published
2019
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30. A Peptide Prodrug Approach for Improving Bisphosphonate Oral Absorption

Author

Ezra, Aviva, primary, Hoffman, Amnon, additional, Breuer, Eli, additional, Alferiev, Ivan S., additional, Mönkkönen, Jukka, additional, El Hanany-Rozen, Naama, additional, Weiss, Gal, additional, Stepensky, David, additional, Gati, Irith, additional, Cohen, Hagit, additional, Törmälehto, Soili, additional, Amidon, Gordon L., additional, and Golomb, Gershon, additional

Published
2000
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34. Development and in vitro characterization of floating sustained-release drug delivery systems of polyphenols.

Author

Rosenzweig, Ohad, Lavy, Eran, Gati, Irith, Kohen, Ron, and Friedman, Michael

Subjects
CONTROLLED release preparations, DRUG delivery systems, POLYPHENOLS, ALBUMINS, POLYMER research, PATIENT compliance
Abstract

The aim of this study was to develop and characterize floating stomach-retentive matrix tablets that will deliver polyphenols in a controlled release manner. The tablets were prepared by direct compression. A number of polymers were examined and egg albumin was chosen in light of a better performance in terms of floating behavior and decomposition time. Dissolution studies for three representative polyphenols loaded into a number of formulations were performed using the 'f2' factor in order to compare release profiles of different polyphenols and formulations. The release data showed a good fit into the power law equation and zero-order kinetics has been determined for some of the systems. Erosion and textural analysis studies revealed that higher concentration of egg albumin results in a higher gel strength that is less susceptible to erosion, potentially leading to a prolonged delivery time of drug. The ability of egg albumin-based tablets to resist high mechanical forces was also determined, while comparison to cellulose-derived polymers revealed that the latter have a much lower ability to resist the same forces. The developed delivery system has the potential to increase the efficacy of the therapy for various pathological stomach conditions and to improve patient compliance. [ABSTRACT FROM AUTHOR]

Published
2013
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