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731 results on '"Gastpar M"'

1. Levo-α-acetylmethadol (LAAM) induced QTc-prolongation - results from a controlled clinical trial

Author

Wieneke H, Conrads H, Wolstein J, Breuckmann F, Gastpar M, Erbel R, and Scherbaum N

Subjects
LAAM, methadone, opiate addiction, cardiac arrhythmia, QTc-interval, Medicine
Abstract

Abstract Background Due to potential proarrhythmic side-effects levo-α-Acetylmethadol (LAAM) is currently not available in EU countries as maintenance drug in the treatment of opiate addiction. However, recent studies and meta-analyses underline the clinical advantages of LAAM with respect to the reduction of heroin use. Thus a reappraisal of LAAM has been demanded. The aim of the present study was to evaluate the relative impact of LAAM on QTc-interval, as a measure of pro-arrhythmic risk, in comparison to methadone, the current standard in substitution therapy. Methods ECG recordings were analysed within a randomized, controlled clinical trial evaluating the efficacy and tolerability of maintenance treatment with LAAM compared with racemic methadone. Recordings were done at two points: 1) during a run-in period with all patients on methadone and 2) 24 weeks after randomisation into methadone or LAAM treatment group. These ECG recordings were analysed with respect to QTc-values and QTc-dispersion. Mean values as well as individual changes compared to baseline parameters were evaluated. QTc-intervals were classified according to CPMP-guidelines. Results Complete ECG data sets could be obtained in 53 patients (31 LAAM-group, 22 methadone-group). No clinical cardiac complications were observed in either group. After 24 weeks, patients receiving LAAM showed a significant increase in QTc-interval (0.409 s ± 0.022 s versus 0.418 s ± 0.028 s, p = 0.046), whereas no significant changes could be observed in patients remaining on methadone. There was no statistically significant change in QTc-dispersion in either group. More patients with borderline prolonged and prolonged QTc-intervals were observed in the LAAM than in the methadone treatment group (n = 7 vs. n = 1; p = 0.1). Conclusions In this controlled trial LAAM induced QTc-prolongation in a higher degree than methadone. Given reports of severe arrhythmic events, careful ECG-monitoring is recommended under LAAM medication.

Published
2009
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2. Rateless Codes for AVC Models

Author

Sarwate, A D and Gastpar, M

Subjects
Adversarial models, arbitrarily varying channels (AVCs), randomization, rateless coding
Abstract

The arbitrarily varying channel (AVC) is a channel model whose state is selected maliciously by an adversary. Fixed-blocklength coding assumes a worst-case bound on the adversary's capabilities, which leads to pessimistic results. This paper defines a variable-length perspective on this problem, for which achievable rates are shown that depend on the realized actions of the adversary. Specifically, rateless codes are constructed which require a limited amount of common randomness. These codes are constructed for two kinds of AVC models. In the first the channel state cannot depend on the channel input, and in the second it can. As a by-product, the randomized coding capacity of the AVC with state depending on the transmitted codeword is found and shown to be achievable with a small amount of common randomness. The results for this model are proved using a randomized strategy based on list decoding.

Published
2010

3. Zero-rate feedback can achieve the empirical capacity

Author

Eswaran, Krishnan, Sarwate, A D, Sahai, Anant, and Gastpar, M

Subjects
information theory, Arbitrarily varying channels, common randomness, feedback communication, hybrid ARQ, individual sequences, rateless codes, universal communication
Abstract

The utility of limited feedback for coding over an individual sequence of DMCs is investigated. This study complements recent results showing how limited or noisy feedback can boost the reliability of communication. A strategy with fixed input distribution $P$ is given that asymptotically achieves rates arbitrarily close to the mutual information induced by P and the state-averaged channel. When the capacity-achieving input distribution is the same over all channel states, this achieves rates at least as large as the capacity of the state-averaged channel, sometimes called the empirical capacity.

Published
2010

6. Antidementiva/Nootropika

Author

Möller, H.-J., Benkert, O., Gastpar, M., Laux, G., Rüther, E., Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde, Gaebel, W., editor, Falkai, P., editor, Möller, H.-J., editor, Benkert, O., editor, Gastpar, M., editor, Laux, G., editor, and Rüther, E., editor

Published
2003
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7. Hypnotika/Antiinsomnika

Author

Möller, H.-J., Benkert, O., Gastpar, M., Laux, G., Rüther, E., Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde, Gaebel, W., editor, Falkai, P., editor, Möller, H.-J., editor, Benkert, O., editor, Gastpar, M., editor, Laux, G., editor, and Rüther, E., editor

Published
2003
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8. Tranquilizer/Anxiolytika

Author

Möller, H.-J., Benkert, O., Gastpar, M., Laux, G., Rüther, E., Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde, Gaebel, W., editor, Falkai, P., editor, Möller, H.-J., editor, Benkert, O., editor, Gastpar, M., editor, Laux, G., editor, and Rüther, E., editor

Published
2003
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9. Neuroleptika (Antipsychotika)

Author

Möller, H.-J., Benkert, O., Gastpar, M., Laux, G., Rüther, E., Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde, Gaebel, W., editor, Falkai, P., editor, Möller, H.-J., editor, Benkert, O., editor, Gastpar, M., editor, Laux, G., editor, and Rüther, E., editor

Published
2003
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11. Suchttherapeutika zur Sucht

Author

Böning, J., Kienast, T., Heinz, A., Lesch, O. -M., Soyka, M., Wiesbeck, G. A., Wodarz, N., Platz, W. E., Scherbaum, N., Davids, E., Gastpar, M., Batra, A., Riederer, Peter, editor, and Laux, Gerd, editor

Published
2006
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12. Psychostimulanzien

Author

Möller, H.-J., Benkert, O., Gastpar, M., Laux, G., Rüther, E., Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde, Gaebel, W., editor, Falkai, P., editor, Möller, H.-J., editor, Benkert, O., editor, Gastpar, M., editor, Laux, G., editor, and Rüther, E., editor

Published
2003
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18. A Unified Discretization Approach to Compute–Forward: From Discrete to Continuous Inputs

Author

Pastore A., Lim S.H., Feng C., Nazer B., and Gastpar M.

Subjects
Linear codes, multiple-access channel, Decoding, Entropy, compute–forward, Lattices, Source coding, physical-layer network coding, Receivers, Codes, information dimension
Abstract

Compute–forward is a coding technique that enables receiver(s) in a network to directly decode one or more linear combinations of the transmitted codewords. Initial efforts focused on Gaussian channels and derived achievable rate regions via nested lattice codes and single-user (lattice) decoding as well as sequential (lattice) decoding. Recently, these results have been generalized to discrete memoryless channels via nested linear codes and joint typicality coding, culminating in a simultaneous-decoding rate region for recovering one or more linear combinations from K users. Using a discretization approach, this paper translates this result into a simultaneous-decoding rate region for a wide class of continuous memoryless channels, including the important special case of Gaussian channels. Additionally, this paper derives a single, unified expression for both discrete and continuous rate regions via an algebraic generalization of Rényi’s information dimension. IEEE

Published
2022

36. Dokumentation der Psychopharmakotherapie

Author

Möller, H.-J., Benkert, O., Gastpar, M., Laux, G., Rüther, E., Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde, Gaebel, W., editor, Falkai, P., editor, Möller, H.-J., editor, Benkert, O., editor, Gastpar, M., editor, Laux, G., editor, and Rüther, E., editor

Published
2003
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40. Recursive implementation of the distributed karhunen-loeve transform

Author

Amar, A., Leshem, A., and Gastpar, M.

Subjects
Image coding -- Innovations, Linear systems -- Usage, Distribution (Probability theory) -- Usage, Real-time control -- Usage, Real-time systems -- Usage, Sensors -- Innovations, Simulation methods -- Usage, Real-time system, Business, Computers, Electronics, Electronics and electrical industries
Published
2010

42. Compute-Forward for DMCs: Simultaneous Decoding of Multiple Combinations

Author

Lim S.H., Feng C., Pastore A., Nazer B., and Gastpar M.

Subjects
Achievable rate region, Algebra, Technical challenges, Linear combinations, Decoding, Algebraic structures, Statistical dependencies, Data_CODINGANDINFORMATIONTHEORY, Multiple access channels, Network information theory, Computer Science::Information Theory, Simultaneous decoding
Abstract

Algebraic network information theory is an emerging facet of network information theory, studying the achievable rates of random code ensembles that have algebraic structure, such as random linear codes. A distinguishing feature is that linear combinations of codewords can sometimes be decoded more efficiently than codewords themselves. The present work further develops this framework by studying the simultaneous decoding of multiple messages. Specifically, consider a receiver in a multi-user network that wishes to decode several messages. Simultaneous joint typicality decoding is one of the most powerful techniques for determining the fundamental limits at which reliable decoding is possible. This technique has historically been used in conjunction with random i.i.d. codebooks to establish achievable rate regions for networks. Recently, it has been shown that, in certain scenarios, nested linear codebooks in conjunction with 'single-user' or sequential decoding can yield better achievable rates. For instance, the compute-forward problem examines the scenario of recovering L = K linear combinations of transmitted codewords over a K-user multiple-access channel (MAC), and it is well established that linear codebooks can yield higher rates. This paper develops bounds for simultaneous joint typicality decoding used in conjunction with nested linear codebooks, and applies them to obtain a larger achievable region for compute-forward over a K-user discrete memoryless MAC. The key technical challenge is that competing codeword tuples that are linearly dependent on the true codeword tuple introduce statistical dependencies, which requires careful partitioning of the associated error events. © 1963-2012 IEEE.

Published
2020

48. Treatment of anxiety, tension and restlessness states with Kava special extract WS® 1490 in general practice: a randomized placebo-controlled double-blind multicenter trial

Author

Gastpar, M. and Klimm, H.D.

Subjects
Medicinal plants -- Usage, Kava plant -- Usage -- Reports, Anxiety -- Care and treatment -- Reports, Biological sciences, Health, Science and technology, Care and treatment, Usage, Reports
Abstract

Summary The efficacy and tolerability of 150 mg/d Kava special extract WS® 1490 were investigated in a randomized, placebo-controlled, double-blind multicenter study in patients suffering from neurotic anxiety (DSM-III-R diagnoses [...]

Published
2003

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