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2. Performance evaluation of a PCR panel (FilmArray® Pneumonia Plus) for detection of respiratory bacterial pathogens in respiratory specimens: A systematic review and meta-analysis

Author

Gastli, Nabil, Cattoir, Vincent, Maataoui, Naouale, Armand-Lefèvre, Laurence, Mitton, Barend, Hoover, Jonathan, Greenland, John R., Posteraro, Brunella, Sanguinetti, Maurizio, Kyriazopoulou, Evdoxia, Giamarellos-Bourboulis, Evangelos J., Menchinelli, Giulia, Joannard, Brune, Moy, Anne-Clotilde, Kimmoun, Antoine, Merkling, Thomas, Berçot, Béatrice, Caméléna, François, Poncin, Thibaut, Deniau, Benjamin, Mebazaa, Alexandre, Dudoignon, Emmanuel, and Dépret, François

Published
2023
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4. Prevention of SARS-CoV-2 transmission during a large, live, indoor gathering (SPRING): a non-inferiority, randomised, controlled trial

Author

Delaugerre, Constance, Foissac, Frantz, Abdoul, Hendy, Masson, Guillaume, Choupeaux, Laure, Dufour, Eric, Gastli, Nabil, Delarue, Severine Mercier, Néré, Marie Laure, Minier, Marine, Gabassi, Audrey, Salmona, Maud, Seguineau, Malika, Schmitt, Sarah, Tonglet, Sébastien, Olivier, Alexis, Poyart, Claire, Le Goff, Jerôme, Lescure, Xavier, Kernéis, Solen, and Tréluyer, Jean-Marc

Published
2022
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5. Multicentric evaluation of BioFire FilmArray Pneumonia Panel for rapid bacteriological documentation of pneumonia

Author

Alviset, Sophie, Armand-Lefèvre, Laurence, Baldeyrou, Marion, Becker, Agathe, Boibieux, André, Bonacorsi, Stéphane, Burucoa, Christophe, Cambau, Emmanuelle, Casalegno, Jean-Sébastien, Cointe, Aurélie, Cremniter, Julie, Destras, Grégory, Duquaire, Paul, Geslain, Guillaume, Gustave, Claude-Alexandre, Jacquier, Hervé, Kouatchet, Achille, Lecorche, Emmanuel, Lejeune, Manon, Lina, Bruno, Mahieu, Rafaël, Maamar, Adel, Michaud, Anthony, Monnard, Céline, Montravers, Philippe, Neuwirth, Catherine, Péan de Ponfilly, Gauthier, Pichon, Maxime, Plouzeau, Chloé, Poyart, Claire, Quenot, Jean-Pierre, Rzepecki, Vincent, Stéphan, Robin, Timsit, Jean-François, Tran-Dinh, Alexy, Vandenesch, François, Vigier, Emmanuelle, Gastli, Nabil, Loubinoux, Julien, Daragon, Matthieu, Lavigne, Jean-Philippe, Saint-Sardos, Pierre, Pailhoriès, Hélène, Lemarié, Carole, Benmansour, Hanaa, d’Humières, Camille, Broutin, Lauranne, Dauwalder, Olivier, Levy, Michael, Auger, Gabriel, Kernéis, Solen, and Cattoir, Vincent

Published
2021
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6. Performance evaluation of a PCR panel (FilmArray® Pneumonia Plus) for detection of respiratory bacterial pathogens in respiratory specimens: A systematic review and meta-analysis

Author

Moy, Anne-Clotilde, primary, Kimmoun, Antoine, additional, Merkling, Thomas, additional, Berçot, Béatrice, additional, Caméléna, François, additional, Poncin, Thibaut, additional, Deniau, Benjamin, additional, Mebazaa, Alexandre, additional, Dudoignon, Emmanuel, additional, Dépret, François, additional, Gastli, Nabil, additional, Cattoir, Vincent, additional, Maataoui, Naouale, additional, Armand-Lefèvre, Laurence, additional, Mitton, Barend, additional, Hoover, Jonathan, additional, Greenland, John R., additional, Posteraro, Brunella, additional, Sanguinetti, Maurizio, additional, Kyriazopoulou, Evdoxia, additional, Giamarellos-Bourboulis, Evangelos J., additional, Menchinelli, Giulia, additional, and Joannard, Brune, additional

Published
2023
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10. Hypervirulent Klebsiella Pneumoniae, an Emerging Cause of Endogenous Endophthalmitis in A French Center: A Comparative Cohort Study.

Author

Martellosio, Jean-Philippe, Gastli, Nabil, Farhat, Rebecca, Tazi, Asmaa, Duraffour, Pierre, Rossi, Benjamin, Canouï, Etienne, Morbieu, Caroline, Billoët, Annick, Mouthon, Luc, Poyart, Claire, Brézin, Antoine, and Legendre, Paul

Subjects
*KLEBSIELLA pneumoniae, *ENDOPHTHALMITIS, *COHORT analysis, *COMPARATIVE studies
Abstract

Klebsiella pneumoniae (KP) is the most common cause of endogenous endophthalmitis (EE) in Asia, but data in Europe are scarce. We describe eight cases of KP EE compared to a cohort of EE in a French center. EE cases were retrospectively studied between January 2014 and January 2021. KP EE cases were analyzed to assess clinical, microbiological features, and outcome. Among the 33 EE cases identified, the first causative agent (24%, n = 8) was KP, mainly (7/8) with hypervirulent phenotype (hvKP). All but one of these cases occurred from December 2019 to January 2021. Contrary to non-KP patients, KP patients had multiple extraocular infective foci (p =.006), all presented with liver abscesses (p <.001), 50% had cerebral involvement (p =.13). Visual outcome was poor in both groups. KP is an emerging cause of EE in a French center, consistently associated with liver abscesses, frequent cerebral involvement, and predominance of hvKP strains. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Hypervirulent Klebsiella Pneumoniae, an Emerging Cause of Endogenous Endophthalmitis in A French Center: A Comparative Cohort Study

Author

Martellosio, Jean-Philippe, primary, Gastli, Nabil, additional, Farhat, Rebecca, additional, Tazi, Asmaa, additional, Duraffour, Pierre, additional, Rossi, Benjamin, additional, Canouï, Etienne, additional, Morbieu, Caroline, additional, Billoët, Annick, additional, Mouthon, Luc, additional, Poyart, Claire, additional, Brézin, Antoine, additional, and Legendre, Paul, additional

Published
2022
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13. Additional file 1 of Antimicrobial stewardship in high-risk febrile neutropenia patients

Author

Contejean, Adrien, Abbara, Salam, Chentouh, Ryme, Alviset, Sophie, Grignano, Eric, Gastli, Nabil, Casetta, Anne, Willems, Lise, Canouï, Etienne, Charlier, Caroline, Pène, Frédéric, Charpentier, Julien, Reboul-Marty, Jeanne, Batista, Rui, Bouscary, Didier, and Kernéis, Solen

Subjects
hemic and lymphatic diseases
Abstract

Additional file 1: Local high-risk febrile neutropenia guidelines.

Published
2022
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14. Multicentric evaluation of BioFire FilmArray Pneumonia Panel for rapid bacteriological documentation of pneumonia

Author

Gastli, Nabil, primary, Loubinoux, Julien, additional, Daragon, Matthieu, additional, Lavigne, Jean-Philippe, additional, Saint-Sardos, Pierre, additional, Pailhoriès, Hélène, additional, Lemarié, Carole, additional, Benmansour, Hanaa, additional, d’Humières, Camille, additional, Broutin, Lauranne, additional, Dauwalder, Olivier, additional, Levy, Michael, additional, Auger, Gabriel, additional, Kernéis, Solen, additional, Cattoir, Vincent, additional, Alviset, Sophie, additional, Armand-Lefèvre, Laurence, additional, Baldeyrou, Marion, additional, Becker, Agathe, additional, Boibieux, André, additional, Bonacorsi, Stéphane, additional, Burucoa, Christophe, additional, Cambau, Emmanuelle, additional, Casalegno, Jean-Sébastien, additional, Cointe, Aurélie, additional, Cremniter, Julie, additional, Destras, Grégory, additional, Duquaire, Paul, additional, Geslain, Guillaume, additional, Gustave, Claude-Alexandre, additional, Jacquier, Hervé, additional, Kouatchet, Achille, additional, Lecorche, Emmanuel, additional, Lejeune, Manon, additional, Lina, Bruno, additional, Mahieu, Rafaël, additional, Maamar, Adel, additional, Michaud, Anthony, additional, Monnard, Céline, additional, Montravers, Philippe, additional, Neuwirth, Catherine, additional, Péan de Ponfilly, Gauthier, additional, Pichon, Maxime, additional, Plouzeau, Chloé, additional, Poyart, Claire, additional, Quenot, Jean-Pierre, additional, Rzepecki, Vincent, additional, Stéphan, Robin, additional, Timsit, Jean-François, additional, Tran-Dinh, Alexy, additional, Vandenesch, François, additional, and Vigier, Emmanuelle, additional

Published
2021
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15. Evaluation of saliva molecular point of care for detection of SARS-CoV-2 in ambulatory care

Author

LeGoff, Jérôme, primary, Kernéis, Solen, additional, Elie, Caroline, additional, Delarue, Séverine Mercier, additional, Gastli, Nabil, additional, Choupeaux, Laure, additional, Fourgeaud, Jacques, additional, Alby, Marie-Laure, additional, Quentin, Pierre, additional, Pavie, Juliette, additional, Brazille, Patricia, additional, Néré, Marie Laure, additional, Minier, Marine, additional, Gabassi, Audrey, additional, Leroy, Chrystel, additional, Parfait, Béatrice, additional, Tréluyer, Jean-Marc, additional, and Delaugerre, Constance, additional

Published
2021
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17. Prevention of Sars-Cov-2 Transmission During a Large, Live, Indoor Gathering: The Noninferiority Randomised-Controlled Spring Trial

Author

Delaugerre, Constance, primary, Foissac, Frantz, additional, Abdoul, Hendy, additional, Masson, Guillaume, additional, Choupeaux, Laure, additional, Dufour, Eric, additional, Gourmelon, Fabrice, additional, Gastli, Nabil, additional, Mercier-Delarue, Severine, additional, Néré, Marie-Laure, additional, Minier, Marine, additional, Gabassi, Audrey, additional, Leroy, Chrystel, additional, Salmona, Maud, additional, Seguineau, Malika, additional, Schmitt, Sarah, additional, Tonglet, Sébastien, additional, Olivier, Alexis, additional, Fischer, Xavier, additional, Taille, Catherine, additional, POYART, Claire, additional, Le Goff, Jérôme, additional, Lescure, Fraçois-Xavier, additional, Kernéis, Solen, additional, and Treluyer, Jean-Marc, additional

Published
2021
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18. Additional file 1 of Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia

Author

Monard, Céline, Pehlivan, Jonathan, Auger, Gabriel, Alviset, Sophie, Dinh, Alexy Tran, Duquaire, Paul, Gastli, Nabil, D’Humières, Camille, Maamar, Adel, Boibieux, André, Baldeyrou, Marion, Loubinoux, Julien, Dauwalder, Olivier, Cattoir, Vincent, Armand-Lefèvre, Laurence, and Kernéis, Solen

Abstract

Additional file 1: Supplementary table 1. Microbiological documentation depending on the sample type (n=159). Supplementary table 2. Impact of the rm-PCR results on antibiotic prescription, according to the multidisciplinary committee and regarding sample type (n=159). Supplementary Table 3. Description of inadequate antibiotic regimen.

Published
2020
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19. Characteristics of Helicobacter pylori strains isolated from Mauritanian patients

Author

Khiddi, Fatimetou, primary, Abdellahi, Mohamed val Mohamed, additional, Horma, Mohamed Abdallah, additional, Billoet, Annick, additional, Collobert, Ghislaine, additional, Amar, Ahmed Mohamed, additional, Nech, Hachem Demine Moctar, additional, Vadel, El Heiba Mohamed, additional, Houmeida, Ahmed, additional, Raymond, Josette, additional, Dauga, Catherine, additional, and Gastli, Nabil, additional

Published
2020
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20. Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia.

Author

Monard, Céline, Pehlivan, Jonathan, Auger, Gabriel, Alviset, Sophie, Tran Dinh, Alexy, Duquaire, Paul, Gastli, Nabil, d'Humières, Camille, Maamar, Adel, Boibieux, André, Baldeyrou, Marion, Loubinoux, Julien, Dauwalder, Olivier, Cattoir, Vincent, Armand-Lefèvre, Laurence, Kernéis, Solen, the ADAPT study group, Becker, Agathe, Charpentier, Julien, and Textoris, Julien

Subjects
PNEUMONIA, RESEARCH, TIME, RESEARCH methodology, ANTI-infective agents, RETROSPECTIVE studies, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, COMMUNITY-acquired infections, POLYMERASE chain reaction
Abstract

Background: Improving timeliness of pathogen identification is crucial to allow early adaptation of antibiotic therapy and improve prognosis in patients with pneumonia. We evaluated the relevance of a new syndromic rapid multiplex PCR test (rm-PCR) on respiratory samples to guide empirical antimicrobial therapy in adult patients with community-acquired pneumonia (CAP), hospital-acquired pneumonia (HAP), and ventilator-acquired pneumonia (VAP).Methods: This retrospective multicenter study was conducted in four French university hospitals. Respiratory samples were obtained from patients with clinical and radiological signs of pneumonia and simultaneously tested using conventional microbiological methods and the rm-PCR. A committee composed of an intensivist, a microbiologist, and an infectious diseases specialist retrospectively assessed all medical files and agreed on the most appropriate antimicrobial therapy for each pneumonia episode, according to the results of rm-PCR and blinded to the culture results. The rm-PCR-guided antimicrobial regimen was compared to the empirical treatment routinely administered to the patient in standard care.Results: We included 159 pneumonia episodes. Most patients were hospitalized in intensive care units (n = 129, 81%), and episodes were HAP (n = 68, 43%), CAP (n = 54, 34%), and VAP (n = 37, 23%). Conventional culture isolated ≥ 1 microorganism(s) at significant level in 95 (60%) patients. The syndromic rm-PCR detected at least one bacteria in 132 (83%) episodes. Based on the results of the rm-PCR, the multidisciplinary committee proposed a modification of the empirical therapy in 123 (77%) pneumonia episodes. The modification was a de-escalation in 63 (40%), an escalation in 35 (22%), and undetermined in 25 (16%) patients. In microbiologically documented episodes (n = 95), the rm-PCR increased appropriateness of the empirical therapy to 83 (87%), as compared to 73 (77%) in routine care.Conclusions: Use of a syndromic rm-PCR test has the potential to reduce unnecessary antimicrobial exposure and increase the appropriateness of empirical antibiotic therapy in adult patients with pneumonia. [ABSTRACT FROM AUTHOR]

Published
2020
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