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17 results on '"Gassull, Daniel"'

9. Are CAR-T therapies living up to their hype?: A study using real-world data in two cohorts to determine how well they are actually working in practice compared with bone marrow transplants

Author

MS Hematologie, Schulthess, Duane, Gassull, Daniel, Makady, Amr, Ludlow, Anna, Rothman, Brian, Have, Pieter Ten, Wu, Yiyang, Ekstrom, Leeland, Minnema, Monique, Jagasia, Madan, MS Hematologie, Schulthess, Duane, Gassull, Daniel, Makady, Amr, Ludlow, Anna, Rothman, Brian, Have, Pieter Ten, Wu, Yiyang, Ekstrom, Leeland, Minnema, Monique, and Jagasia, Madan

Published
2021

10. Are CAR-T therapies living up to their hype? A study using real-world data in two cohorts to determine how well they are actually working in practice compared with bone marrow transplants

Author

Schulthess, Duane, primary, Gassull, Daniel, additional, Makady, Amr, additional, Ludlow, Anna, additional, Rothman, Brian, additional, Have, Pieter ten, additional, Wu, Yiyang, additional, Ekstrom, Leeland, additional, Minnema, Monique, additional, and Jagasia, Madan, additional

Published
2019
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11. Electrochemical sensing of membrane potential and enzyme function using gallium arsenide electrodes functionalized with supported membranes

Author

Gassull, Daniel, Ulman, Abraham, Grunze, Michael, and Tanaka, Motomu

Subjects
Electrolytes -- Electric properties, Electrolytes -- Chemical properties, Gallium arsenide -- Electric properties, Membrane potentials -- Evaluation, Chemicals, plastics and rubber industries
Abstract

The gallium arsenide electrodes functionalized with the supported membranes in the form of a biofunctional electrolyte-insulator-semiconductor (EIS) setup are discussed. The analysis reveals that the discussed EIS setup can also be used for the electrochemical sensing of the membrane potential and enzyme functions.

Published
2008

12. Are CAR-T therapies living up to their hype? A study using real-world data in two cohorts to determine how well they are actually working in practice compared with bone marrow transplants

Author

Schulthess, Duane, Gassull, Daniel, Makady, Amr, Ludlow, Anna, Rothman, Brian, Have, Pieter ten, Wu, Yiyang, Ekstrom, Leeland, Minnema, Monique, and Jagasia, Madan

Abstract

With the increasing use of new regulatory tools, like the Food and Drug Administration’s breakthrough designation, there are increasing challenges for European health technology assessors (HTAs) to make an accurate assessment of the long-term value and performance of chimeric antigen receptor T-cell (CAR-T) therapies, particularly for orphan conditions, such as acute lymphoblastic leukaemia. The aim of this study was to demonstrate a novel methodology harnessing longitudinal real-world data, extracted from the electronic health records of a medical centre functioning as a clinical trial site, to develop an accurate analysis of the performance of CAR-T compared with the next-best treatment option, namely allogeneic haematopoietic cell transplant (HCT). The study population comprised 43 subjects in two cohorts: 29 who had undergone HCT treatment and 14 who had undergone CAR-T therapy. The 3-year relapse-free survival probability was 46% (95% CI: 08% to 79%) in the CAR-T cohort and 68% (95% CI: 46% to 83%) in the HCT cohort. To explain the lower RFS probability in the CAR-T cohort compared with the HCT cohort, the authors hypothesised that the CAR-T cohort had a far higher level of disease burden. This was validated by log-rank test analysis (p=0.0001) and confirmed in conversations with practitioners at the study site. The authors are aware that the small populations in this study will be seen as limiting the generalisability of the findings to some readers. However, in consultation with many European HTAs and regulators, there is broad agreement that this methodology warrants further investigation with a larger study.

Published
2021
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13. Elektrochemische Detektion von chemischen und biochemischen Reaktionen auf Gallium-Arsenid-basierten Halbleitern, funktionalisiert mit bio-organischen molekularen Systemen

Author

Gassull, Daniel, Tanaka, Motomu (Prof. Dr.), and Rief, Matthias (Prof. Dr.)

Subjects
Physik, ddc:530, GaAs, Biosensor, Impedanzspektroskopie, pH-Empfindlichkeit, Hydrophobie, GaAs, Biosensor, Impedance Spectroscopy, pH sensitivity, Hydrophobicity, Supported Membranes, Surface Potential, Membrane Potential
Abstract

The aim of the work is the electrochemical characterization of GaAs surfaces functionalized with bioorganic molecules towards chemical/biochemical sensor applications. Due to an excellent electrochemical stability achieved by deposition of biphenylthiol monolayers, GaAs electrodes can be subjected to electrochemical impedance spectroscopy to identify different electrochemical layers quantitatively. The interface resistance of functionalized bulk GaAs shows distinct pH sensitivity, influenced by the type of electrolyte counter anion, which is comparable to that obtained by two-dimensional electron gas devices. As the first step of biofunctionalization, lipid monolayers are deposited on GaAs pre-coated with thiol monolayers. GaAs coated with a highly insulating lipid membrane is electrochemical stable for more than several days, exhibiting a high sensitivity to membrane surface potentials and enzymatic reaction. Die Arbeit umfasst die elektrochemische Charakterisierung von GaAs Oberflächen, funktionalisiert mit bioorganischen Molekülen, mit Hinblick auf die (bio)chemische Sensoranwendung. GaAs Elektroden können durch das Aufbringen von Biphenylthiol Monolagen auf Grund ihrer elektrochemischen Stabilität zur quantitativen Identifizierung unterschiedlicher Schichten in der Impedanzspektroskopie verwendet werden. Dabei weist der Grenzflächenwiderstand eine pH-Empfindlichkeit auf, die durch verschiedene Gegenionen beeinflußt ist, welche vergleichbar ist mit der von zwei-dimensionalen Elektronengas-Anwendungen. Die Biofunktionalisierung wird durch den Übertrag einer stark isolierenden Lipid Monolage auf den Biphenyl-GaAs Hybrid erreicht, welcher in Elektrolyten elektrochemisch stabil ist. Dieser weist eine hohe Empfindlichkeit gegenüber Membranoberflächen-Potentiale und enzymatischer Reaktionen auf.

Published
2007

14. Electrochemical Sensing of Surface Reactions on Gallium Arsenide-Based Semiconductor Devices Functionalized with Bio-organic Molecular Systems

Author

Rief, Matthias (Prof. Dr.), Tanaka, Motomu (Prof. Dr.), Gassull, Daniel, Rief, Matthias (Prof. Dr.), Tanaka, Motomu (Prof. Dr.), and Gassull, Daniel

Abstract

The aim of the work is the electrochemical characterization of GaAs surfaces functionalized with bioorganic molecules towards chemical/biochemical sensor applications. Due to an excellent electrochemical stability achieved by deposition of biphenylthiol monolayers, GaAs electrodes can be subjected to electrochemical impedance spectroscopy to identify different electrochemical layers quantitatively. The interface resistance of functionalized bulk GaAs shows distinct pH sensitivity, influenced by the type of electrolyte counter anion, which is comparable to that obtained by two-dimensional electron gas devices. As the first step of biofunctionalization, lipid monolayers are deposited on GaAs pre-coated with thiol monolayers. GaAs coated with a highly insulating lipid membrane is electrochemical stable for more than several days, exhibiting a high sensitivity to membrane surface potentials and enzymatic reaction., Die Arbeit umfasst die elektrochemische Charakterisierung von GaAs Oberflächen, funktionalisiert mit bioorganischen Molekülen, mit Hinblick auf die (bio)chemische Sensoranwendung. GaAs Elektroden können durch das Aufbringen von Biphenylthiol Monolagen auf Grund ihrer elektrochemischen Stabilität zur quantitativen Identifizierung unterschiedlicher Schichten in der Impedanzspektroskopie verwendet werden. Dabei weist der Grenzflächenwiderstand eine pH-Empfindlichkeit auf, die durch verschiedene Gegenionen beeinflußt ist, welche vergleichbar ist mit der von zwei-dimensionalen Elektronengas-Anwendungen. Die Biofunktionalisierung wird durch den Übertrag einer stark isolierenden Lipid Monolage auf den Biphenyl-GaAs Hybrid erreicht, welcher in Elektrolyten elektrochemisch stabil ist. Dieser weist eine hohe Empfindlichkeit gegenüber Membranoberflächen-Potentiale und enzymatischer Reaktionen auf.

Published
2007

15. Electrochemical Sensing of Surface Reactions on Gallium Arsenide-Based Semiconductor Devices Functionalized with Bio-organic Molecular Systems

Author

Tanaka, Motomu (Prof. Dr.), Rief, Matthias (Prof. Dr.), Gassull, Daniel, Tanaka, Motomu (Prof. Dr.), Rief, Matthias (Prof. Dr.), and Gassull, Daniel

Abstract

The aim of the work is the electrochemical characterization of GaAs surfaces functionalized with bioorganic molecules towards chemical/biochemical sensor applications. Due to an excellent electrochemical stability achieved by deposition of biphenylthiol monolayers, GaAs electrodes can be subjected to electrochemical impedance spectroscopy to identify different electrochemical layers quantitatively. The interface resistance of functionalized bulk GaAs shows distinct pH sensitivity, influenced by the type of electrolyte counter anion, which is comparable to that obtained by two-dimensional electron gas devices. As the first step of biofunctionalization, lipid monolayers are deposited on GaAs pre-coated with thiol monolayers. GaAs coated with a highly insulating lipid membrane is electrochemical stable for more than several days, exhibiting a high sensitivity to membrane surface potentials and enzymatic reaction., Die Arbeit umfasst die elektrochemische Charakterisierung von GaAs Oberflächen, funktionalisiert mit bioorganischen Molekülen, mit Hinblick auf die (bio)chemische Sensoranwendung. GaAs Elektroden können durch das Aufbringen von Biphenylthiol Monolagen auf Grund ihrer elektrochemischen Stabilität zur quantitativen Identifizierung unterschiedlicher Schichten in der Impedanzspektroskopie verwendet werden. Dabei weist der Grenzflächenwiderstand eine pH-Empfindlichkeit auf, die durch verschiedene Gegenionen beeinflußt ist, welche vergleichbar ist mit der von zwei-dimensionalen Elektronengas-Anwendungen. Die Biofunktionalisierung wird durch den Übertrag einer stark isolierenden Lipid Monolage auf den Biphenyl-GaAs Hybrid erreicht, welcher in Elektrolyten elektrochemisch stabil ist. Dieser weist eine hohe Empfindlichkeit gegenüber Membranoberflächen-Potentiale und enzymatischer Reaktionen auf.

Published
2007

17. Are CAR-T therapies living up to their hype? A study using real-world data in two cohorts to determine how well they are actually working in practice compared with bone marrow transplants.

Author

Schulthess D, Gassull D, Makady A, Ludlow A, Rothman B, Have PT, Wu Y, Ekstrom L, Minnema M, and Jagasia M

Subjects
Bone Marrow Transplantation, Humans, Receptors, Chimeric Antigen, T-Lymphocytes, Hematopoietic Stem Cell Transplantation, Immunotherapy, Adoptive
Abstract

With the increasing use of new regulatory tools, like the Food and Drug Administration's breakthrough designation, there are increasing challenges for European health technology assessors (HTAs) to make an accurate assessment of the long-term value and performance of chimeric antigen receptor T-cell (CAR-T) therapies, particularly for orphan conditions, such as acute lymphoblastic leukaemia. The aim of this study was to demonstrate a novel methodology harnessing longitudinal real-world data, extracted from the electronic health records of a medical centre functioning as a clinical trial site, to develop an accurate analysis of the performance of CAR-T compared with the next-best treatment option, namely allogeneic haematopoietic cell transplant (HCT). The study population comprised 43 subjects in two cohorts: 29 who had undergone HCT treatment and 14 who had undergone CAR-T therapy. The 3-year relapse-free survival probability was 46% (95% CI: 08% to 79%) in the CAR-T cohort and 68% (95% CI: 46% to 83%) in the HCT cohort. To explain the lower RFS probability in the CAR-T cohort compared with the HCT cohort, the authors hypothesised that the CAR-T cohort had a far higher level of disease burden. This was validated by log-rank test analysis (p=0.0001) and confirmed in conversations with practitioners at the study site. The authors are aware that the small populations in this study will be seen as limiting the generalisability of the findings to some readers. However, in consultation with many European HTAs and regulators, there is broad agreement that this methodology warrants further investigation with a larger study., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2021
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