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8 results on '"Gassner, Joseph Maria George Vernon"'

2. Quality assessment by bile composition in normothermic machine perfusion of rat livers

Author

Muth, Vanessa, primary, Strobl, Felix, additional, Michelotto, Julian, additional, Gilles, LInda, additional, Kirwan, Jennifer, additional, Eisenberger, Alina, additional, Marchand, Jeremy, additional, Roschke, Nathalie, additional, Moosburner, Simon, additional, Pratschke, Johann, additional, Sauer, Igor M., additional, Raschzok, Nathanael, additional, and Gassner, Joseph Maria George Vernon, additional

Published
2024
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4. Early Allograft Dysfunction Increases Hospital Associated Costs After Liver Transplantation—A Propensity Score–Matched Analysis

Author

Moosburner, Simon, Sauer, Igor M., F��rster, Frank, Winklmann, Thomas, Gassner, Joseph Maria George Vernon, Ritschl, Paul V., ��llinger, Robert, Pratschke, Johann, and Raschzok, Nathanael

Subjects
surgical procedures, operative, Cold Ischemia, lcsh:Diseases of the digestive system. Gastroenterology, Hospital Costs, lcsh:RC799-869, Allografts, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, Donor Selection, Liver Transplantation
Abstract

Concepts to ameliorate the continued mismatch between demand for liver allografts and supply include the acceptance of allografts that meet extended donor criteria (ECD). ECD grafts are generally associated with an increased rate of complications such as early allograft dysfunction (EAD). The costs of liver transplantation for the health care system with respect to specific risk factors remain unclear and are subject to change. We analyzed 317 liver transplant recipients from 2013 to 2018 for outcome after liver transplantation and hospital costs in a German transplant center. In our study period, 1-year survival after transplantation was 80.1% (95% confidence interval: 75.8%-84.6%) and median hospital stay was 33 days (interquartile rage: 24), with mean hospital costs of euro115,924 (SD euro113,347). There was a positive correlation between costs and laboratory Model for End-Stage Liver Disease score (r(s) = 0.48, P < 0.001), and the development of EAD increased hospital costs by euro26,229. ECD grafts were not associated with a higher risk of EAD in our cohort. When adjusting for recipient-associated risk factors such as laboratory Model for End-Stage Liver Disease score, recipient age, and split liver transplantation with propensity score matching, only EAD and cold ischemia increased total costs. Conclusion: Our data show that EAD leads to significantly higher hospital costs for liver transplantation, which are primarily attributed to recipient health status. Strategies to reduce the incidence of EAD are needed to control costs in liver transplantation.

Published
2021

5. Advancing small-animal perfusion models: Normothermic dual-vessel ex vivo rat liver machine perfusion based on a clinical setup

Author

Strobl, Felix, primary, Michelotto, Julian, additional, Muth, Vanessa, additional, Moosburner, Simon, additional, Knaub, Kristina, additional, Zimmer, Maximilian, additional, Pratschke, Johann, additional, Sauer, Igor Maximilian, additional, Raschzok, Nathanael, additional, and Gassner, Joseph Maria George Vernon, additional

Published
2022
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7. Development of a Rat Liver Machine Perfusion System for Normothermic and Subnormothermic Conditions

Author

Nösser, Maximilian, primary, Gassner, Joseph Maria George Vernon, additional, Moosburner, Simon, additional, Wyrwal, David, additional, Claussen, Felix, additional, Hillebrandt, Karl Herbert, additional, Horner, Rosa, additional, Tang, Peter, additional, Reutzel-Selke, Anja, additional, Polenz, Dietrich, additional, Arsenic, Ruza, additional, Pratschke, Johann, additional, Sauer, Igor Maximilian, additional, and Raschzok, Nathanael, additional

Published
2020
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8. Ex vivo liver machine perfusion: comprehensive review of common animal models

Author

Muth, Vanessa, Gassner, Joseph Maria George Vernon, Moosburner, Simon, Lurje, Georg, Michelotto, Julian, Strobl, Felix, Knaub, Kristina, Engelmann, Cornelius, Tacke, Frank, Selzner, Markus, Pratschke, Johann, Sauer, Igor M., and Raschzok, Nathanael

Abstract

The most common preservation technique for liver grafts is static cold storage. Due to the organ shortage for liver transplantation, extended criteria donation (ECD) allografts are increasingly used – despite the higher risk of inferior outcome after transplantation. Ex vivo liver machine perfusion has been developed to improve the outcome of liver transplantation, especially with ECD grafts, and is currently under evaluation in clinical trials. We performed a literature search on PubMed and ISI Web of Science to assemble an overview of rodent and porcine animal models of ex vivo liver machine perfusion for transplantation, which are essential for the present and future development of clinical liver machine perfusion. Hypothermic, subnormothermic and normothermic MP systems have been successfully used for rat and pig liver transplantation. In comparison to hypothermic systems, normothermic perfusion often incorporates a dialysis unit. Moreover, it enables metabolic assessment of liver grafts. Allografts experiencing warm ischemic time have a superior survival rate after machine perfusion compared to cold storage alone, irrespective of the temperature used for perfusion. Furthermore, ex vivo machine perfusion improves the outcome of regular and ECD liver grafts in animal models. Small and large animal models of ex vivo liver machine perfusion are available to further foster the development of this new technology.

Published
2022
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