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438 results on '"Gasser, C."'

1. Primäre intrakranielle und spinale Tumoren

Author

Diener, H C, Gerloff-Gasser, C, Dieterich, Marianne, Endres, Matthias; https://orcid.org/0000-0001-6520-3720, Diener, H C ( H C ), Gerloff-Gasser, C ( C ), Dieterich, M ( Marianne ), Endres, M ( Matthias ), Wick, W, Vajkoczy, P, Weller, Michael; https://orcid.org/0000-0002-1748-174X, Diener, H C, Gerloff-Gasser, C, Dieterich, Marianne, Endres, Matthias; https://orcid.org/0000-0001-6520-3720, Diener, H C ( H C ), Gerloff-Gasser, C ( C ), Dieterich, M ( Marianne ), Endres, M ( Matthias ), Wick, W, Vajkoczy, P, and Weller, Michael; https://orcid.org/0000-0002-1748-174X

Published
2023

2. Hirnmetastasen

Author

Diener, Hans-Christoph, Gerloff-Gasser, C, Dieterich, Marianne, Endres, Matthias; https://orcid.org/0000-0001-6520-3720, Diener, H ( Hans-Christoph ), Gerloff-Gasser, C ( C ), Dieterich, M ( Marianne ), Endres, M ( Matthias ), Winkler, F, Westphal, Laura P; https://orcid.org/0000-0002-8373-3132, Weller, Michael; https://orcid.org/0000-0002-1748-174X, Diener, Hans-Christoph, Gerloff-Gasser, C, Dieterich, Marianne, Endres, Matthias; https://orcid.org/0000-0001-6520-3720, Diener, H ( Hans-Christoph ), Gerloff-Gasser, C ( C ), Dieterich, M ( Marianne ), Endres, M ( Matthias ), Winkler, F, Westphal, Laura P; https://orcid.org/0000-0002-8373-3132, and Weller, Michael; https://orcid.org/0000-0002-1748-174X

Published
2023

3. Towards virtual histology with X-ray grating interferometry

Author

Polikarpov, M., primary, Vila-Comamala, J., additional, Wang, Z., additional, Pereira, A., additional, van Gogh, S., additional, Gasser, C., additional, Jefimovs, K., additional, Romano, L., additional, Varga, Z., additional, Lång, K., additional, Schmeltz, M., additional, Tessarini, S., additional, Rawlik, M., additional, Jermann, E., additional, Lewis, S., additional, Yun, W., additional, and Stampanoni, M., additional

Published
2023
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15. Regulation of lactose, glucose and sucrose metabolisms in S. thermophilus.

Author

Gasser, C., Faurie, J.M., and Rul, F.

Subjects
*YOGURT, *SUCROSE, *GLUCOSE metabolism, *CARBOHYDRATE metabolism, *LACTOSE, *FERMENTED foods, *SACCHARIDES
Abstract

Streptococcus thermophilus is a bacterium widely used in the production of yogurts and cheeses, where it efficiently ferments lactose, the saccharide naturally present in milk. It is also employed as a starter in dairy- or plant-based fermented foods that contain saccharides other than lactose (e.g., sucrose, glucose). However, little is known about how saccharide use is regulated, in particular when saccharides are mixed. Here, we determine the effect of the 5 sugars that S. thermophilus is able to use, at different concentration and when they are mixed on the promoter activities of the C-metabolism genes. Using a transcriptional fusion approach, we discovered that lactose and glucose modulated the activity of the lacS and scrA promoters in a concentration-dependent manner. When mixed with lactose, glucose also repressed the two promoter activities; when mixed with sucrose, lactose still repressed scrA promoter activity. We determined that catabolite control protein A (CcpA) played a key role in these dynamics. We also showed that promoter activity was linked with glycolytic flux, which varied depending on saccharide type and concentration. Overall, this study identified key mechanisms in carbohydrate metabolism - autoregulation and partial hierarchical control - and demonstrated that they are partly mediated by CcpA. •Glucose repressed promoter activity for transporter-encoding genes lacS and scrA. • Sucrose concentration did not affect promoter activity for carbon metabolism genes. • Catabolite control protein A (CcpA) repressed lacS promoter activity. • Promoter activity of lacS and scrA genes was linked to the glycolytic flux. • Carbohydrate use was partially hierarchical controlled in mixed-saccharide media. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Agranulocytosen und Granulocytopenien (Neutropenien)

Author

Gasser, C., Opitz, H., editor, Schmid, F., editor, Weicker, H., editor, Althoff, H., editor, Baumgartner, G., editor, Beckmann, R., editor, Betke, K., editor, Bettex, M., editor, Burgio, G. R., editor, Cottier, H., editor, Damerow, R., editor, Degenhardt, K.-H., editor, Diemer, K., editor, Emrich, R., editor, Fey, F., editor, Fichsel, H., editor, Flatz, G., editor, Garby, L., editor, Gasser, C., editor, Gugler, E., editor, Hansen, H. G., editor, Hauke, H., editor, Haupt, H., editor, Hitzig, W. H., editor, Hövels, O., editor, Jacobi, H., editor, Jéquier, S., editor, Jonxis, J. H. P., editor, Kaufmann, H. J., editor, Kleihauer, E. F., editor, Künzer, W., editor, Kuhnke, E., editor, Laissue, J., editor, Leiber, B., editor, Lüscher, E. F., editor, Maier, W. A., editor, Marti, H. R., editor, Merker, H., editor, Murken, J.-D., editor, Oehme, J., editor, Ofteringer, K., editor, Plenert, W., editor, Rind, H. J., editor, Rogner, G., editor, Roos, B., editor, Ruhrmann, G., editor, Schönenberg, H., editor, Schröder, G., editor, Spranger, J., editor, Stobbe, H., editor, Theiler, K., editor, Thomas, G., editor, Tönz, O., editor, Versé, H., editor, Vest, M., editor, Weippl, G., editor, Weyers, H., editor, Wiedemann, H.-R., editor, and Wilhelm, G., editor

Published
1967
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17. Pathogenetisch uneinheitliche Anämien : Anaemia pseudoleucaemica infantum (Jaksch-Hayem-Luzet-Syndrom)

Author

Gasser, C., Plenert, W., Opitz, H., editor, Schmid, F., editor, Weicker, H., editor, Althoff, H., editor, Baumgartner, G., editor, Beckmann, R., editor, Betke, K., editor, Bettex, M., editor, Burgio, G. R., editor, Cottier, H., editor, Damerow, R., editor, Degenhardt, K.-H., editor, Diemer, K., editor, Emrich, R., editor, Fey, F., editor, Fichsel, H., editor, Flatz, G., editor, Garby, L., editor, Gasser, C., editor, Gugler, E., editor, Hansen, H. G., editor, Hauke, H., editor, Haupt, H., editor, Hitzig, W. H., editor, Hövels, O., editor, Jacobi, H., editor, Jéquier, S., editor, Jonxis, J. H. P., editor, Kaufmann, H. J., editor, Kleihauer, E. F., editor, Künzer, W., editor, Kuhnke, E., editor, Laissue, J., editor, Leiber, B., editor, Lüscher, E. F., editor, Maier, W. A., editor, Marti, H. R., editor, Merker, H., editor, Murken, J.-D., editor, Oehme, J., editor, Ofteringer, K., editor, Plenert, W., editor, Rind, H. J., editor, Rogner, G., editor, Roos, B., editor, Ruhrmann, G., editor, Schönenberg, H., editor, Schröder, G., editor, Spranger, J., editor, Stobbe, H., editor, Theiler, K., editor, Thomas, G., editor, Tönz, O., editor, Versé, H., editor, Vest, M., editor, Weippl, G., editor, Weyers, H., editor, Wiedemann, H.-R., editor, and Wilhelm, G., editor

Published
1967
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18. Verkürzung der Erythrocytenlebensdauer: Hämolytische Anämien : Hereditäre, corpusculäre, hämolytische Anämien

Author

Tönz, O., Damerow, R., Betke, K., Gasser, C., Opitz, H., editor, Schmid, F., editor, Weicker, H., editor, Althoff, H., editor, Baumgartner, G., editor, Beckmann, R., editor, Betke, K., editor, Bettex, M., editor, Burgio, G. R., editor, Cottier, H., editor, Damerow, R., editor, Degenhardt, K.-H., editor, Diemer, K., editor, Emrich, R., editor, Fey, F., editor, Fichsel, H., editor, Flatz, G., editor, Garby, L., editor, Gasser, C., editor, Gugler, E., editor, Hansen, H. G., editor, Hauke, H., editor, Haupt, H., editor, Hitzig, W. H., editor, Hövels, O., editor, Jacobi, H., editor, Jéquier, S., editor, Jonxis, J. H. P., editor, Kaufmann, H. J., editor, Kleihauer, E. F., editor, Künzer, W., editor, Kuhnke, E., editor, Laissue, J., editor, Leiber, B., editor, Lüscher, E. F., editor, Maier, W. A., editor, Marti, H. R., editor, Merker, H., editor, Murken, J.-D., editor, Oehme, J., editor, Ofteringer, K., editor, Plenert, W., editor, Rind, H. J., editor, Rogner, G., editor, Roos, B., editor, Ruhrmann, G., editor, Schönenberg, H., editor, Schröder, G., editor, Spranger, J., editor, Stobbe, H., editor, Theiler, K., editor, Thomas, G., editor, Tönz, O., editor, Versé, H., editor, Vest, M., editor, Weippl, G., editor, Weyers, H., editor, Wiedemann, H.-R., editor, and Wilhelm, G., editor

Published
1967
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21. Genetic Analysis of Ovule Morphogenesis

Author

Gasser, C. S., Hill, T. A., Kuzoff, R. K., McAbee, J. M., Meister, R. J., and Skinner, D. J.

Subjects
Developmental genetics -- Research, Ovum -- Growth, Morphogenesis -- Genetic aspects, Biological sciences
Abstract

Development of ovules (the precursors to seeds) serves as an attractive model to study mechanisms regulating plant morphogenesis. Formation of Arabidopsis ovules requires establishment of a developmental pattern along the proximal-distal and abaxial-adaxial axes. Following this pattern, regions of an ovule primordium take on specific developmental fates and undergo morphogenetic changes through differential cell expansion and division. We, and others, have identified mutants in at least 17 different genetic loci regulating morphogenetic processes in ovule development. INNER NO OUTER (INO) encodes a putative transcription factor which has an essential role in abaxial-adaxial patterning and subsequent asymmetric development of the outer integument of the ovule. Analysis of mutants and specifically designed transgenic plants shows that INO positively regulates its own expression and that a second gene, SUPERMAN (SUP), is necessary for proper spatial confinement of INO gene expression. HUELLENLOS (HLL), AINTEGUMENTA (ANT), and SHORT INTEGUMENTS 2 (SIN2) have both independent and redundant roles in several early aspects of ovule development. The varied nature of the products of these genes highlights how an interplay between gene regulation and modulation of basic metabolic processes can lead to specific morphological alterations. Some ovule mutants mimic known evolutionary changes in ovule form, and our results may thus help elucidate the natural history of the ovule. (Supported by grants from NSF and USDA/NRICGP.)

Published
2001

22. Phimosis et corticostéroïdes topiques : une alternative au traitement chirurgical? : revue Cochrane pour le praticien

Author

Flatz, A., Rey-Bellet Gasser, C., and Peytremann-Bridevaux, I.

Abstract

Question clinique: Une mère vous consulte avec son fils âgé de 6 ans, en bonne santé habituelle mais connu pour un phimosis. Il ne présente pas de troubles mictionnels, ni d'antécédents de balanite ou de paraphimosis. Sa mère est inquiète de voir le phimosis persister et vous demande s'il existe une alternative au traitement chirurgical. Contexte: Présent dès la naissance, le phimosis physiologique se résout spontanément dans la majorité des cas. Alors que 10% des garçons présentent un phimosis à l'âge de 3 ans, cette prévalence diminue à 6-8% à l'âge de 7 ans, pour atteindre 1% à l'âge de 16 ans. On parle de phimosis pathologique lorsque le prépuce présente des cicatrices fibreuses suite à des inflammations répétées ou des décalottages forcés. Cependant, la distinction clinique entre un phimosis pathologique et physiologique est difficile et le traitement chirurgical reste fréquent. Un traitement par corticostéroïdes topiques est utilisé depuis de nombreuses années pour son action anti-inflammatoire et immunosuppressive (diminution de la production de collagène). Pourtant, il n'existe pas de preuve quant à l'efficacité et la sécurité de ce traitement.

Published
2015

25. Brewer's spent grain:Future biorefinery raw material

Author

Kemppainen, Katariina, Rommi, Katariina, Gasser, C., Mucha, M., and Corvini, P.

Subjects
brewer's spent grain, lignin depolymerization, technology, industry, and agriculture, food and beverages, fractionation, pretreatment
Abstract

Brewer's spent grain (BSG), an abundantly available side-stream from the brewing industry, was treated to extract lipids, hydrolyse carbohydrates to monosaccharides, isolate protein and depolymerize lignin to produce fractions valuable to the food, feed, fuel, and chemical industries. Steam explosion and organosolv cooking were found to improve the enzymatic digestibility of BSG carbohydrates from 30% to over 80% hydrolysis yield. The solids loading during the hydrolysis was shown to affect the hydrolysis yield, but promising results were reached even at 20% dry matter content. The treatment of the lignin-rich fraction with oxidative enzymes was found to lead into polymerization reactions suggesting that it would beneficiary to use radical scavengers and continuously separate low molecular weight compounds from the reaction medium.

Published
2014

35. Literaturübersicht zum selbst organisierten Lernen (SOL)

Author

Kyburz-Graber, R, Canella, C, Gerloff-Gasser, C, Pangrazzi, R, University of Zurich, and Bildungsdirektion Kanton Zürich, Mittelschul- und Berufsbildungs, (MBA)

Subjects
10091 Institute of Education, 370 Education
Published
2009

39. 5—Enolpyruvylshikimate 3—Phosphate Synthase

Author

Kishore, G., primary, Shah, D., additional, Padgette, S., additional, della-Cioppa, G., additional, Gasser, C., additional, Re, D., additional, Hironaka, C., additional, Taylor, M., additional, Wibbenmeyer, J., additional, Eichholtz, D., additional, Hayford, M., additional, Hoffmann, N., additional, Delannay, X., additional, Horsch, R., additional, Klee, H., additional, Rogers, S., additional, Rochester, D., additional, Brundage, L., additional, Sanders, P., additional, and Fraley, R. T., additional

Published
1988
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42. Störung der Normoblastenentkernung: Pseudoaplastische Anämie

Author

Weicker, H., primary, Althoff, H., additional, Baumgartner, G., additional, Beckmann, R., additional, Betke, K., additional, Bettex, M., additional, Burgio, G. R., additional, Cottier, H., additional, Damerow, R., additional, Degenhardt, K.-H., additional, Diemer, K., additional, Emrich, R., additional, Fey, F., additional, Fichsel, H., additional, Flatz, G., additional, Garby, L., additional, Gasser, C., additional, Gugler, E., additional, Hansen, H. G., additional, Hauke, H., additional, Haupt, H., additional, Hitzig, W. H., additional, Hövels, O., additional, Jacobi, H., additional, Jéquier, S., additional, Jonxis, J. H. P., additional, Kaufmann, H. J., additional, Kleihauer, E. F., additional, Künzer, W., additional, Kuhnke, E., additional, Laissue, J., additional, Leiber, B., additional, Lüscher, E. F., additional, Maier, W. A., additional, Marti, H. R., additional, Merker, H., additional, Murken, J.-D., additional, Oehme, J., additional, Ofteringer, K., additional, Plenert, W., additional, Rind, H. J., additional, Rogner, G., additional, Roos, B., additional, Ruhrmann, G., additional, Schmid, F., additional, Schönenberg, H., additional, Schröder, G., additional, Spranger, J., additional, Stobbe, H., additional, Theiler, K., additional, Thomas, G., additional, Tönz, O., additional, Versé, H., additional, Vest, M., additional, Weippl, G., additional, Weyers, H., additional, Wiedemann, H.-R., additional, and Wilhelm, G., additional

Published
1967
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46. Selbsteinschätzungsbogen 'Selbst organisiertes Lernen' (SOL)

Author

Bildungsdirektion Kanton Zürich, Mittelschul- und Berufsbildungs, (MBA), Bildungsdirektion Kanton Zürich, Mittelschul- und Berufsbildungs, ( ( (MBA) ), Kyburz-Graber, R, Canella, C, Gerloff-Gasser, C, Pangrazzi, R, Bildungsdirektion Kanton Zürich, Mittelschul- und Berufsbildungs, (MBA), Bildungsdirektion Kanton Zürich, Mittelschul- und Berufsbildungs, ( ( (MBA) ), Kyburz-Graber, R, Canella, C, Gerloff-Gasser, C, and Pangrazzi, R

Published
2009

47. Überfachliche Kompetenzen durch selbst organisiertes Lernen erwerben

Author

Bildungsdirektion Kanton Zürich, Mittelschul- und Berufsbildungs, (MBA), Bildungsdirektion Kanton Zürich, Mittelschul- und Berufsbildungs, ( ( (MBA) ), Kyburz-Graber, R, Canella, C, Gerloff-Gasser, C, Pangrazzi, R, Bildungsdirektion Kanton Zürich, Mittelschul- und Berufsbildungs, (MBA), Bildungsdirektion Kanton Zürich, Mittelschul- und Berufsbildungs, ( ( (MBA) ), Kyburz-Graber, R, Canella, C, Gerloff-Gasser, C, and Pangrazzi, R

Published
2009

48. Literaturübersicht zum selbst organisierten Lernen (SOL)

Author

Bildungsdirektion Kanton Zürich, Mittelschul- und Berufsbildungs, (MBA), Bildungsdirektion Kanton Zürich, Mittelschul- und Berufsbildungs, ( ( (MBA) ), Kyburz-Graber, R, Canella, C, Gerloff-Gasser, C, Pangrazzi, R, Bildungsdirektion Kanton Zürich, Mittelschul- und Berufsbildungs, (MBA), Bildungsdirektion Kanton Zürich, Mittelschul- und Berufsbildungs, ( ( (MBA) ), Kyburz-Graber, R, Canella, C, Gerloff-Gasser, C, and Pangrazzi, R

Published
2009

49. Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration

Author

Grundler, R, Brault, L, Gasser, C, Bullock, A, Dechow, T, Woetzel, S, Pogacic, V, Villa, A, Ehret, S, Berridge, G, Spoo, A, Dierks, C, Biondi, A, Knapp, S, Duyster, J, Schwaller, J, Bullock, AN, Schwaller, J., VILLA, ANTONELLO, BIONDI, ANDREA, Grundler, R, Brault, L, Gasser, C, Bullock, A, Dechow, T, Woetzel, S, Pogacic, V, Villa, A, Ehret, S, Berridge, G, Spoo, A, Dierks, C, Biondi, A, Knapp, S, Duyster, J, Schwaller, J, Bullock, AN, Schwaller, J., VILLA, ANTONELLO, and BIONDI, ANDREA

Abstract

FLT3-ITD-mediated leukemogenesis is associated with increased expression of oncogenic PIM serine/threonine kinases. To dissect their role in FLT3-ITD-mediated transformation, we performed bone marrow reconstitution assays. Unexpectedly, FLT3-ITD cells deficient for PIM1 failed to reconstitute lethally irradiated recipients, whereas lack of PIM2 induction did not interfere with FLT3-ITD-induced disease. PIM1-deficient bone marrow showed defects in homing and migration and displayed decreased surface CXCR4 expression and impaired CXCL12-CXCR4 signaling. Through small interfering RNA-mediated knockdown, chemical inhibition, expression of a dominant-negative mutant, and/or reexpression in knockout cells, we found PIM1 activity to be essential for proper CXCR4 surface expression and migration of cells toward a CXCL12 gradient. Purified PIM1 led to the phosphorylation of serine 339 in the CXCR4 intracellular domain in vitro, a site known to be essential for normal receptor recycling. In primary leukemic blasts, high levels of surface CXCR4 were associated with increased PIM1 expression, and this could be significantly reduced by a small molecule PIM inhibitor in some patients. Our data suggest that PIM1 activity is important for homing and migration of hematopoietic cells through modification of CXCR4. Because CXCR4 also regulates homing and maintenance of cancer stem cells, PIM1 inhibitors may exert their antitumor effects in part by interfering with interactions with the microenvironment.

Published
2009

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