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1. Cerebellar and subcortical atrophy contribute to psychiatric symptoms in frontotemporal dementia

Author: Bussy, A., Levy, J., Best, T., Patel, R., Cupo, L., Van Langenhove, T., Nielsen, J., Pijnenburg, Y., Waldö, M., Remes, A., Schroeter, M., Santana, I., Pasquier, F., Otto, M., Danek, A., Levin, J., Le Ber, I., Vandenberghe, R., Synofzik, M., Moreno, F., de Mendonça, A., Sanchez‐Valle, R., Laforce, R., Langheinrich, T., Gerhard, A., Graff, C., Butler, C., Sorbi, S., Jiskoot, L., Seelaar, H., van Swieten, J., Finger, E., Tartaglia, M., Masellis, M., Tiraboschi, P., Galimberti, D., Borroni, B., Rowe, J., Bocchetta, M., Rohrer, J., Devenyi, G., Chakravarty, M., Ducharme, S., Esteve, A., Nelson, A., Bouzigues, A., Heller, C., Greaves, C., Cash, D., Thomas, D., Todd, E., Benotmane, H., Zetterberg, H., Swift, I., Nicholas, J., Samra, K., Russell, L., Shafei, R., Convery, R., Timberlake, C., Cope, T., Rittman, T., Benussi, A., Premi, E., Gasparotti, R., Archetti, S., Gazzina, S., Cantoni, V., Arighi, A., Fenoglio, C., Scarpini, E., Fumagalli, G., Borracci, V., Rossi, G., Giaccone, G., Di Fede, G., Caroppo, P., Prioni, S., Redaelli, V., Tang‐Wai, D., Rogaeva, E., Castelo‐Branco, M., Freedman, M., Keren, R., Black, S., Mitchell, S., Shoesmith, C., Bartha, R., Rademakers, R., Poos, J., Papma, J., Giannini, L., van Minkelen, R., Nacmias, B., Ferrari, C., Polito, C., Lombardi, G., Bessi, V., Veldsman, M., Andersson, C., Thonberg, H., Öijerstedt, L., Jelic, V., Thompson, P., Lladó, A., Antonell, A., Olives, J., Balasa, M., Bargalló, N., Borrego‐Ecija, S., Verdelho, A., Maruta, C., Ferreira, C., Miltenberger, G., do Couto, F., Gabilondo, A., Gorostidi, A., Villanua, J., Cañada, M., Tainta, M., Zulaica, M., Barandiaran, M., Alves, P., Bender, B., Wilke, C., Graf, L., Vogels, A., Vandenbulcke, M., Van Damme, P., Bruffaerts, R., Poesen, K., Rosa‐Neto, P., Gauthier, S., Camuzat, A., Brice, A., Bertrand, A., Funkiewiez, A., Rinaldi, D., Saracino, D., Colliot, O., Sayah, S., Prix, C., Wlasich, E., Wagemann, O., Loosli, S., Schönecker, S., Hoegen, T., Lombardi, J., Anderl‐Straub, S., Rollin, A., Kuchcinski, G., Bertoux, M., Lebouvier, T., Deramecourt, V., Santiago, B., Duro, D., Leitão, M., Almeida, M., Tábuas‐Pereira, M., Afonso, S., Engel, A., Polyakova, M., Erasmus MC other, Neurology, Radiology & Nuclear Medicine, Clinical Genetics, GENetic Frontotemporal dementia Initiative (GENFI), Lombardi, Gemma, Bessi, Valentina, Veldsman, Michele, Andersson, Christin, Thonberg, Hakan, Öijerstedt, Linn, Jelic, Vesna, Thompson, Paul, Langheinrich, Tobias, Lladó, Albert, Antonell, Anna, Olives, Jaume, Balasa, Mircea, Bargalló, Nuria, Borrego-Ecija, Sergi, Verdelho, Ana, Maruta, Carolina, Ferreira, Catarina B, Miltenberger, Gabriel, do Couto, Frederico Simões, Gabilondo, Alazne, Gorostidi, Ana, Villanua, Jorge, Cañada, Marta, Tainta, Mikel, Zulaica, Miren, Barandiaran, Myriam, Alves, Patricia, Bender, Benjamin, Wilke, Carlo, Graf, Lisa, Vogels, Annick, Vandenbulcke, Mathieu, Van Damme, Philip, Bruffaerts, Rose, Poesen, Koen, Rosa-Neto, Pedro, Gauthier, Serge, Camuzat, Agnès, Brice, Alexis, Bertrand, Anne, Funkiewiez, Aurélie, Rinaldi, Daisy, Saracino, Dario, Colliot, Olivier, Sayah, Sabrina, Prix, Catharina, Wlasich, Elisabeth, Wagemann, Olivia, Loosli, Sandra, Schönecker, Sonja, Hoegen, Tobias, Lombardi, Jolina, Anderl-Straub, Sarah, Rollin, Adeline, Kuchcinski, Gregory, Bertoux, Maxime, Lebouvier, Thibaud, Deramecourt, Vincent, Santiago, Beatriz, Duro, Diana, Leitão, Maria João, Almeida, Maria Rosario, Tábuas-Pereira, Miguel, Afonso, Sónia, Engel, Annerose, Polyakova, Maryna, Esteve, Aitana Sogorb, Nelson, Annabel, Bouzigues, Arabella, Heller, Carolin, Greaves, Caroline V, Cash, David, Thomas, David L, Todd, Emily, Benotmane, Hanya, Zetterberg, Henrik, Swift, Imogen J, Nicholas, Jennifer, Samra, Kiran, Russell, Lucy L, Bocchetta, Martina, Shafei, Rachelle, Convery, Rhian S, Timberlake, Carolyn, Cope, Thomas, Rittman, Timothy, Benussi, Alberto, Premi, Enrico, Gasparotti, Roberto, Archetti, Silvana, Gazzina, Stefano, Cantoni, Valentina, Arighi, Andrea, Fenoglio, Chiara, Scarpini, Elio, Fumagalli, Giorgio, Borracci, Vittoria, Rossi, Giacomina, Giaccone, Giorgio, Di Fede, Giuseppe, Caroppo, Paola, Tiraboschi, Pietro, Prioni, Sara, Redaelli, Veronica, Tang-Wai, David, Rogaeva, Ekaterina, Castelo-Branco, Miguel, Freedman, Morris, Keren, Ron, Black, Sandra, Mitchell, Sara, Shoesmith, Christen, Bartha, Robart, Rademakers, Rosa, Poos, Jackie, Papma, Janne M, Giannini, Lucia, van Minkelen, Rick, Pijnenburg, Yolande, Nacmias, Benedetta, Ferrari, Camilla, Polito, Cristina, Bussy, Aurélie [0000-0001-6695-9941], Nielsen, Jørgen E [0000-0003-0453-5582], Borroni, Barbara [0000-0001-9340-9814], Bocchetta, Martina [0000-0003-1814-5024], Devenyi, Gabriel A [0000-0002-7766-1187], Apollo - University of Cambridge Repository, and Amsterdam Neuroscience - Neurodegeneration
Subjects: C9orf72 Protein, Radiological and Ultrasound Technology, Medizin, frontotemporal dementia, Neurology, Frontotemporal Dementia, Cerebellum, Humans, magnetic resonance imaging, genetics, neuropsychiatry, Radiology, Nuclear Medicine and imaging, Human medicine, ddc:610, Neurology (clinical), Atrophy, Anatomy, genetics [Frontotemporal Dementia], genetics [C9orf72 Protein]
Abstract: Funder: Alzheimer Society of Canada; Id: http://dx.doi.org/10.13039/501100000143, Funder: Weston Brain Institute; Id: http://dx.doi.org/10.13039/100012479, Funder: Fonds de Recherche du Québec ‐ Santé, Funder: Canadian Institutes of Health Research; Id: http://dx.doi.org/10.13039/501100000024, Funder: NIHR Rare Diseases Translational Research Collaboration, Funder: Deutsche Forschungsgemeinschaft; Id: http://dx.doi.org/10.13039/501100001659, Recent studies have reported early cerebellar and subcortical impact in the disease progression of genetic frontotemporal dementia (FTD) due to microtubule-associated protein tau (MAPT), progranulin (GRN) and chromosome 9 open reading frame 72 (C9orf72). However, the cerebello-subcortical circuitry in FTD has been understudied despite its essential role in cognition and behaviors related to FTD symptomatology. The present study aims to investigate the association between cerebellar and subcortical atrophy, and neuropsychiatric symptoms across genetic mutations. Our study included 983 participants from the Genetic Frontotemporal dementia Initiative including mutation carriers and noncarrier first-degree relatives of known symptomatic carriers. Voxel-wise analysis of the thalamus, striatum, globus pallidus, amygdala, and the cerebellum was performed, and partial least squares analyses (PLS) were used to link morphometry and behavior. In presymptomatic C9orf72 expansion carriers, thalamic atrophy was found compared to noncarriers, suggesting the importance of this structure in FTD prodromes. PLS analyses demonstrated that the cerebello-subcortical circuitry is related to neuropsychiatric symptoms, with significant overlap in brain/behavior patterns, but also specificity for each genetic mutation group. The largest differences were in the cerebellar atrophy (larger extent in C9orf72 expansion group) and more prominent amygdalar volume reduction in the MAPT group. Brain scores in the C9orf72 expansion carriers and MAPT carriers demonstrated covariation patterns concordant with atrophy patterns detectable up to 20 years before expected symptom onset. Overall, these results demonstrated the important role of the subcortical structures in genetic FTD symptom expression, particularly the cerebellum in C9orf72 and the amygdala in MAPT carriers.
Published: 2023

2. Motor symptoms in genetic frontotemporal dementia: developing a new module for clinical rating scales

Author: Samra, K, MacDougall, AM, Peakman, G, Bouzigues, A, Bocchetta, M, Cash, DM, Greaves, CV, Convery, RS, van Swieten, JC, Jiskoot, L, Seelaar, H, Butler, CR, Fenoglio, C, Rohrer, JD, Gerhard, A, Ducharme, S, Le Ber, I, Tiraboschi, P, Santana, I, Pasquier, F, Levin, J, Shoesmith, C, Otto, M, Russell, LL, Nelson, A, Cash, D, Thomas, DL, Todd, E, Ferrari, C, Benotmane, H, Timberlake, C, Gabilondo, A, Cope, T, Rittman, T, Benussi, A, Premi, E, Gasparotti, R, Thompson, P, Archetti, S, Fumagalli, G, do Couto, FS, Borracci, V, Polito, C, Rossi, G, Giaccone, G, Di Fede, G, Caroppo, P, Ferreira, CB, Prioni, S, Langheinrich, T, Redaelli, V, Lladó, A, Bartha, R, Tang-Wai, D, Rogaeva, E, Castelo-Branco, M, Freedman, M, Keren, R, Black, S, Mitchell, S, Miltenberger, G, Rademakers, R, Poos, J, Papma, JM, Giannini, L, van Minkelen, R, Pijnenburg, Y, Gauthier, S, Nacmias, B, Lombardi, G, Bessi, V, Veldsman, M, Andersson, C, Thonberg, H, Öijerstedt, L, Prix, C, Jelic, V, Antonell, A, Graff, C, Olives, J, Balasa, M, Bargalló, N, Borrego-Ecija, S, Verdelho, A, Kuchcinski, G, Maruta, C, Gorostidi, A, Laforce, R, Villanua, J, Wlasich, E, Cañada, M, Tainta, M, Zulaica, M, Barandiaran, M, Moreno, F, Alves, P, Bender, B, Bertoux, M, Wilke, C, Lebouvier, T, Camuzat, A, Graf, L, Vogels, A, Vandenbulcke, M, Van Damme, P, Bruffaerts, R, Poesen, K, Rosa-Neto, P, Sanchez-Valle, R, Brice, A, Bertrand, A, Funkiewiez, A, Rinaldi, D, Saracino, D, Colliot, O, Sorbi, S, Sayah, S, Wagemann, O, Loosli, S, Schönecker, S, Hoegen, T, Lombardi, J, Anderl-Straub, S, Nicholas, J, Rollin, A, Deramecourt, V, Arighi, A, Santiago, B, Duro, D, Leitão, MJ, Almeida, MR, Tábuas-Pereira, M, Gazzina, S, Afonso, S, Masellis, M, Tartaglia, C, Shafei, R, Rowe, JB, Borroni, B, Finger, E, Synofzik, M, Galimberti, D, Vandenberghe, R, de Mendonça, A, Cantoni, V, Genetic FTD Initiative (GENFI), Samra, Kiran [0000-0002-3105-7099], Apollo - University of Cambridge Repository, Maruta, Carolina, Ferreira, Catarina B, Miltenberger, Gabriel, do Couto, Frederico Simões, Gabilondo, Alazne, Gorostidi, Ana, Villanua, Jorge, Cañada, Marta, Tainta, Mikel, Zulaica, Miren, Barandiaran, Myriam, Alves, Patricia, Bender, Benjamin, Wilke, Carlo, Graf, Lisa, Vogels, Annick, Vandenbulcke, Mathieu, Van Damme, Philip, Bruffaerts, Rose, Poesen, Koen, Rosa-Neto, Pedro, Gauthier, Serge, Camuzat, Agnès, Brice, Alexis, Bertrand, Anne, Funkiewiez, Aurélie, Rinaldi, Daisy, Saracino, Dario, Colliot, Olivier, Sayah, Sabrina, Prix, Catharina, Wlasich, Elisabeth, Wagemann, Olivia, Loosli, Sandra, Schönecker, Sonja, Hoegen, Tobias, Lombardi, Jolina, Anderl-Straub, Sarah, Rollin, Adeline, Kuchcinski, Gregory, Bertoux, Maxime, Lebouvier, Thibaud, Deramecourt, Vincent, Santiago, Beatriz, Duro, Diana, Leitão, Maria João, Almeida, Maria Rosario, Tábuas-Pereira, Miguel, Afonso, Sónia, Nelson, Annabel, Bocchetta, Martina, Cash, David, Thomas, David L, Todd, Emily, Benotmane, Hanya, Nicholas, Jennifer, Samra, Kiran, Shafei, Rachelle, Timberlake, Carolyn, Cope, Thomas, Rittman, Timothy, Benussi, Alberto, Premi, Enrico, Gasparotti, Roberto, Archetti, Silvana, Gazzina, Stefano, Cantoni, Valentina, Arighi, Andrea, Fenoglio, Chiara, Fumagalli, Giorgio, Borracci, Vittoria, Rossi, Giacomina, Giaccone, Giorgio, Di Fede, Giuseppe, Caroppo, Paola, Tiraboschi, Pietro, Prioni, Sara, Redaelli, Veronica, Tang-Wai, David, Rogaeva, Ekaterina, Castelo-Branco, Miguel, Freedman, Morris, Keren, Ron, Black, Sandra, Mitchell, Sara, Shoesmith, Christen, Bartha, Robart, Rademakers, Rosa, Poos, Jackie, Papma, Janne M, Giannini, Lucia, van Minkelen, Rick, Pijnenburg, Yolande, Nacmias, Benedetta, Ferrari, Camilla, Polito, Cristina, Lombardi, Gemma, Bessi, Valentina, Veldsman, Michele, Andersson, Christin, Thonberg, Hakan, Öijerstedt, Linn, Jelic, Vesna, Thompson, Paul, Langheinrich, Tobias, Lladó, Albert, Antonell, Anna, Olives, Jaume, Balasa, Mircea, Bargalló, Nuria, Borrego-Ecija, Sergi, and Verdelho, Ana
Subjects: Progranulin, Clinical Neurology, C9ORF72, tau Proteins, AMYOTROPHIC-LATERAL-SCLEROSIS, diagnosis [Frontotemporal Dementia], C9orf72, Tremor, Genetics, Humans, ddc:610, genetics [Frontotemporal Dementia], genetics [C9orf72 Protein], MUTATION, Science & Technology, C9orf72 Protein, HERITABILITY, Amyotrophic Lateral Sclerosis, PROGRESSIVE SUPRANUCLEAR PALSY, COGNITIVE IMPAIRMENT, REPEAT EXPANSION, genetics [tau Proteins], Motor, PATHOLOGICAL FEATURES, Neurology, FOS: Biological sciences, Frontotemporal Dementia, Mutation, Human medicine, Neurosciences & Neurology, Neurology (clinical), Tau, TAU, Life Sciences & Biomedicine, Frontotemporal dementia, PARKINSONISM
Abstract: Funder: CIBERNED, Funder: Canadian Institutes of Health Research; doi: http://dx.doi.org/10.13039/501100000024, Funder: Lemaire Family Foundation, Funder: Swedish Frontotemporal Dementia Initiative, Funder: Italian Ministry of Health, Funder: Weston Brain Institute; doi: http://dx.doi.org/10.13039/100012479, Funder: Mady Browaaeys Fund, Funder: Miriam Marks Brain Research UK, Funder: Bluefield Project, OBJECTIVE: To investigate the optimal method of adding motor features to a clinical rating scale for frontotemporal dementia (FTD). METHODS: Eight hundred and thirty-two participants from the international multicentre Genetic FTD Initiative (GENFI) study were recruited: 522 mutation carriers (with C9orf72, GRN and MAPT mutations) and 310 mutation-negative controls. A standardised clinical questionnaire was used to assess eight motor symptoms (dysarthria, dysphagia, tremor, slowness, weakness, gait disorder, falls and functional difficulties using hands). Frequency and severity of each motor symptom was assessed, and a principal component analysis (PCA) was performed to identify how the different motor symptoms loaded together. Finally, addition of a motor component to the CDR® plus NACC FTLD was investigated (CDR® plus NACC FTLD-M). RESULTS: 24.3% of mutation carriers had motor symptoms (31.7% C9orf72, 18.8% GRN, 19.3% MAPT) compared to 6.8% of controls. Slowness and gait disorder were the commonest in all genetic groups while tremor and falls were the least frequent. Symptom severity scores were similar to equivalent physical motor examination scores. PCA revealed that all motor symptoms loaded together so a single additional motor component was added to the CDR® plus NACC FTLD to form the CDR® plus NACC FTLD-M. Individual global scores were more severe with the CDR® plus NACC FTLD-M, and no patients with a clinically diagnosed motor disorder (ALS/FTD-ALS or parkinsonism) were classified anymore as asymptomatic (unlike the CDR® plus NACC FTLD alone). CONCLUSIONS: Motor features are present in mutation carriers at all disease stages across all three genetic groups. Inclusion of motor symptoms in a rating scale that can be used in future clinical trials will not only ensure a more accurate severity measure is recorded but that a wider spectrum of FTD phenotypes can be included in the same trial.
Published: 2022

3. Multimodal evaluation of carpal tunnel syndrome in a pre-symptomatic TTR mutation carrier

Author: Salvalaggio, A., primary, Cacciavillani, M., additional, Tiengo, C., additional, Cipriani, A., additional, Frizziero, L., additional, Fedrigo, M., additional, Rizzo, S., additional, Angelini, A., additional, Gasparotti, R., additional, and Briani, C., additional
Published: 2023
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4. Mechanical thrombectomy in patients with heart failure: the Italian registry of Endovascular Treatment in Acute Stroke

Author: Gentile, L, Pracucci, G, Saia, V, Falcou, A, Biraschi, F, Zini, A, Simonetti, L, Riva, L, Bigliardi, G, Vallone, S, Nencini, P, Limbucci, N, Diomedi, M, Da Ros, V, Longoni, M, Ruggiero, M, Tassinari, T, Allegretti, L, Cerrato, P, Rubino, E, Bergui, M, Cavallo, R, Naldi, A, Comelli, C, Cappellari, M, Zivelonghi, C, Plebani, M, De Vito, A, Merli, N, Saletti, A, Musolino, Rf, Ferraù, L, Vinci, Sl, Sacco, S, Orlandi, B, De Santis, F, Filauri, P, Ruiz, L, Sepe, Fn, Gallesio, I, Petruzzellis, M, Chiumarulo, L, Sangalli, D, Salmaggi, A, Filizzolo, M, Moller, J, Melis, M, Comelli, S, Magoni, M, Gilberti, N, Gasparotti, R, Invernizzi, P, Pavia, M, Pinto, V, Laspada, S, Marcheselli, S, Ajello, D, Viaro, F, Baracchini, C, Causin, F, Giannini, N, Caselli, Mc, Mancuso, M, Cosottini, M, Scoditti, U, Menozzi, R, Russo, M, Amistá, P, Napoletano, R, Romano, Dg, Tassi, R, Bracco, S, Carimati, F, Versino, M, Giorgianni, A, De Boni, A, Fasano, A, Barbarini, L, Paladini, A, Franchini, E, Dall'Ora, E, Comai, A, Giovanni, F, Pedicelli, A, Sallustio, F, Casetta, I, Fainardi, E, Mangiafico, S, and Toni, D
Subjects: Left ventricular ejection fraction, Acute ischemic stroke, Heart failure, Mechanical thrombectomy, Settore MED/37 - Neuroradiologia, Settore MED/26
Published: 2023

5. Multimodal evaluation of carpal tunnel syndrome in a pre-symptomatic TTR mutation carrier

Author: Salvalaggio, A., Cacciavillani, M., Tiengo, C., Cipriani, A., Frizziero, L., Fedrigo, M., Rizzo, S., Angelini, A., Gasparotti, R., and Briani, C.
Subjects: Hereditary Transthyrethin amyloidosis, Neurology, ATTRv, Ultrasonography, Carpal tunnel syndrome, Hereditary Transthyrethin amyloidosis, ATTRv, Nerve ultrasound, Neurology (clinical), Nerve ultrasound, cross-sectional-area, cross-sectional-area
Published: 2023

6. Is aceruloplasminemia treatable? Combining iron chelation and fresh-frozen plasma treatment

Author: Poli, L., Alberici, A., Buzzi, P., Marchina, E., Lanari, A., Arosio, C., Ciccone, A., Semeraro, F., Gasparotti, R., Padovani, A., and Borroni, Barbara
Published: 2017
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7. Subcortical matter in the α-synucleinopathies spectrum: an MRI pilot study

Author: Gazzina, S., Premi, E., Turrone, R., Acosta-Cabronero, J., Rizzetti, M. C., Cotelli, M. S., Gasparotti, R., Padovani, A., and Borroni, B.
Published: 2016
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8. Modelling the cascade of biomarker changes in GRN-related frontotemporal dementia

Author: Panman, J. L., Venkatraghavan, V., Van Der Ende, E. L., Steketee, R. M. E., Jiskoot, L. C., Poos, J. M., Dopper, E. G. P., Meeter, L. H. H., Kaat, L. D., Rombouts, S. A. R. B., Vernooij, M. W., Kievit, A. J. A., Premi, E., Cosseddu, M., Bonomi, E., Olives, J., Rohrer, J. D., Sanchez-Valle, R., Borroni, B., Bron, E. E., Van Swieten, J. C., Papma, J. M., Klein, S., Afonso, S., Almeida, M. R., Anderl-Straub, S., Andersson, C., Antonell, A., Archetti, S., Arighi, A., Balasa, M., Barandiaran, M., Bargallo, N., Bartha, R., Bender, B., Black, S., Butler, C., Bocchetta, M., Borrego-Ecija, S., Bras, J., Bruffaerts, R., Caroppo, P., Cash, D., Castelo-Branco, M., Convery, R., Cope, T., Danek, A., De Arriba, M., De Mendonca, A., Di Fede, G., Diaz, Z., Ducharme, S., Duro, D., Fenoglio, C., Ferreira, C. B., Finger, E., Flanagan, T., Fox, N., Freedman, M., Fumagalli, G., Gabilondo, A., Galimberti, D., Gasparotti, R., Gauthier, S., Gazzina, S., Gerhard, A., Giaccone, G., Gorostidi, A., Graff, C., Greaves, C., Guerreiro, R., Heller, C., Hoegen, T., Indakoetxea, B., Jelic, V., Karnath, H. -O., Keren, R., Laforce, R., Leitao, M. J., Levin, J., Llado, A., Loosli, S., Maruta, C., Masellis, M., Mead, S., Miltenberger, G., Van Minkelenm Sara Mitchell, R., Moore, K., Moreno, F., Nicholas, J., Oijerstedt, L., Otto, M., Ourselin, S., Padovani, A., Peakman, G., Pijnenburg, Y., Polito, C., Prioni, S., Prix, C., Rademakers, R., Redaelli, V., Rittman, T., Rogaeva, E., Rosa-Neto, P., Rossi, G., Rosser, M., Rowe, J., Santana, I., Santiago, B., Scarpini, E., Schonecker, S., Shafei, E. S. R., Shoesmith, C., Synofzik, M., Tabuas-Pereira, M., Tagliavini, F., Tartaglia, C., Tainta, M., Taipa, R., Tang-Wai, D., Thomas, D. L., Thonberg, H., Timberlake, C., Tiraboschi, P., Todd, E., Vandamme, P., Vandenberghe, R., Vandenbulcke, M., Veldsman, M., Verdelho, A., Villanua, J., Warren, J., Wilkeione, C., Elisabeth, W., Henrik, W., Zulaica, Z. M., Neurology, Physics and medical technology, Radiology & Nuclear Medicine, Clinical Genetics, and Medical Research Council
Subjects: Male, Oncology, Disease, Neuropsychological Tests, GENFI consortium investigators, Primary progressive aphasia, Cognition, Progranulins, 0302 clinical medicine, Neurofilament Proteins, BEHAVIORAL VARIANT, HETEROGENEITY, Gray Matter, 11 Medical and Health Sciences, Language, Psychiatry, 0303 health sciences, Brain, Middle Aged, Magnetic Resonance Imaging, White Matter, 17 Psychology and Cognitive Sciences, ALZHEIMERS-DISEASE, Psychiatry and Mental health, Phenotype, medicine.anatomical_structure, Frontotemporal Dementia, Disease Progression, Biomarker (medicine), Female, Life Sciences & Biomedicine, Frontotemporal dementia, medicine.medical_specialty, Clinical Neurology, EVENT-BASED MODEL, Grey matter, Lateralization of brain function, White matter, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Internal medicine, NEUROFILAMENT LIGHT-CHAIN, medicine, Humans, LOBAR DEGENERATION, PROGRANULIN, Aged, 030304 developmental biology, Science & Technology, Neurology & Neurosurgery, business.industry, DISEASE PROGRESSION, medicine.disease, Mutation, WHITE-MATTER INTEGRITY, Surgery, Neurosciences & Neurology, Neurology (clinical), business, GENFI, Biomarkers, 030217 neurology & neurosurgery, Progressive disease
Abstract: ObjectiveProgranulin-related frontotemporal dementia (FTD-GRN) is a fast progressive disease. Modelling the cascade of multimodal biomarker changes aids in understanding the aetiology of this disease and enables monitoring of individual mutation carriers. In this cross-sectional study, we estimated the temporal cascade of biomarker changes for FTD-GRN, in a data-driven way.MethodsWe included 56 presymptomatic and 35 symptomatic GRN mutation carriers, and 35 healthy non-carriers. Selected biomarkers were neurofilament light chain (NfL), grey matter volume, white matter microstructure and cognitive domains. We used discriminative event-based modelling to infer the cascade of biomarker changes in FTD-GRN and estimated individual disease severity through cross-validation. We derived the biomarker cascades in non-fluent variant primary progressive aphasia (nfvPPA) and behavioural variant FTD (bvFTD) to understand the differences between these phenotypes.ResultsLanguage functioning and NfL were the earliest abnormal biomarkers in FTD-GRN. White matter tracts were affected before grey matter volume, and the left hemisphere degenerated before the right. Based on individual disease severities, presymptomatic carriers could be delineated from symptomatic carriers with a sensitivity of 100% and specificity of 96.1%. The estimated disease severity strongly correlated with functional severity in nfvPPA, but not in bvFTD. In addition, the biomarker cascade in bvFTD showed more uncertainty than nfvPPA.ConclusionDegeneration of axons and language deficits are indicated to be the earliest biomarkers in FTD-GRN, with bvFTD being more heterogeneous in disease progression than nfvPPA. Our data-driven model could help identify presymptomatic GRN mutation carriers at risk of conversion to the clinical stage.
Published: 2021

9. 200P Increase of vertebral fractures in patients with metastatic breast cancer treated with endocrine therapy combined with CDK 4/6 inhibitor

Author: Lorini, L., primary, Conforti, E., additional, Frigerio, M., additional, Laini, L., additional, Amoroso, V., additional, Alberti, A., additional, Schivardi, G., additional, Di Mauro, P., additional, Cosentini, D., additional, Vassalli, L., additional, Cremaschi, V., additional, Esposito, A., additional, Simoncini, E.L., additional, Gasparotti, R., additional, Berruti, A., additional, and Pedersini, R., additional
Published: 2022
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10. Carotid artery stenting during endovascular thrombectomy for acute ischemic stroke with tandem occlusion: the Italian Registry of Endovascular Treatment in Acute Stroke

Author: Sallustio, Fabrizio, Pracucci, Giovanni, Cappellari, Manuel, Saia, Valentina, Mascolo, Alfredo Paolo, Marrama, Federico, Gandini, Roberto, Koch, Giacomo, Diomedi, Marina, D’Agostino, Federica, Rocco, Alessandro, Da Ros, Valerio, Wlderk, Andrea, Nezzo, Marco, Argirò, Renato, Morosetti, Daniele, Renieri, Leonardo, Nencini, Patrizia, Vallone, Stefano, Zini, Andrea, Bigliardi, Guido, Pitrone, Antonio, Grillo, Francesco, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Naldi, Andrea, Carità, Giuseppe, Casetta, Ilaria, Gasparotti, Roberto, Magoni, Mauro, Simonetti, Luigi, Haznedari, Nicolò, Paolucci, Matteo, Mavilio, Nicola, Malfatto, Laura, Menozzi, Roberto, Genovese, Antonio, Cosottini, Mirco, Orlandi, Giovanni, Comai, Alessio, Franchini, Enrica, Pedicelli, Alessandro, Frisullo, Giovanni, Puglielli, Edoardo, Casalena, Alfonsina, Cester, Giacomo, Baracchini, Claudio, Castellano, Davide, Di Liberto, Alessandra, Ricciardi, Giuseppe Kenneth, Chiumarulo, Luigi, Petruzzellis, Marco, Lafe, Elvis, Persico, Alessandra, Cavasin, Nicola, Critelli, Adriana, Semeraro, Vittorio, Tinelli, Angelica, Giorgianni, Andrea, Carimati, Federico, Auteri, William, Rizzuto, Stefano, Biraschi, Francesco, Nicolini, Ettore, Ferrari, Antonio, Melis, Maurizio, Calia, Stefano, Tassinari, Tiziana, Nuzzi, Nunzio Paolo, Corato, Manuel, Sacco, Simona, Squassina, Guido, Invernizzi, Paolo, Gallesio, Ivan, Ruiz, Luigi, Dui, Giovanni, Carboni, Nicola, Amistà, Pietro, Russo, Monia, Maiore, Mario, Zanda, Bastianina, Craparo, Giuseppe, Mannino, Marina, Inzitari, Domenico, Toni, Danilo, Mangiafico, Salvatore, Gasparotti, R., Inzitari, D., Mangiafico, S., Toni, D., Vallone, S., Zini, A., Bergui, M., Causin, F., Ciccone, A., Nencini, P., Saletti, A., Sallustio, F., Tassi, R., Thyrion, F. Zappoli, Pracucci, G., Saia, V., Gandini, R., Da Ros, V., Greco, L., Morosetti, D., Diomedi, M., Nappini, S., Limbucci, N., Renieri, L., Fainardi, E., Verganti, L., Sacchetti, F., Zelent, G., Bigliardi, G., Dell’Acqua, M. L., Picchetto, L., Vandelli, L., Pentore, R., Maffei, S., Nichelli, P., Longo, M., Pitrone, A., Vinci, S. L., Velo, M., Caragliano, A., Tessitore, A., Bonomo, O., Musolino, R., La Spina, P., Casella, C., Fazio, M. C., Grillo, F., Cotroneo, M., Dell’Aera, C., Francalanza, I., Bracco, S., Cioni, S., Gennari, P., Vallone, I. M., Cerase, A., Martini, G., Stura, G., Daniele, D., Cerrato, P., Naldi, A., Onofrio, M., De Vito, A., Azzini, C., Casetta, I., Mardighian, D., Frigerio, M., Magoni, M., Costa, A., Simonetti, L., Cirillo, L., Taglialatela, F., Isceri, S., Princiotta, C., Dall’Olio, M., Cellerini, M., Gentile, M., Piccolo, L., Migliaccio, L., Brancaleoni, L., Naldi, F., Romoli, M., Zaniboni, A., Ruggiero, M., Sanna, A., Haznedari, N., Commodaro, C., Longoni, M., Biguzzi, S., Cordici, F., Malatesta, E., Castellan, L., Mavilio, N., Salsano, G., Malfatto, L., Finocchi, C., Menozzi, R., Piazza, P., Epifani, E., Andreone, A., Scoditti, U., Castellini, P., Latte, L., Grisendi, I., Cosottini, M., Puglioli, M., Lazzarotti, G., Lauretti, D., Mancuso, M., Giannini, N., Maccarone, M., Orlandi, G., Comai, A., Bonatti, G., Nano, G., Ferro, F., Bonatti, M., Dall’Ora, E., Dossi, R. Currò, Turri, E., Turri, M., Colosimo, C., Pedicelli, A., D’Argento, F., Alexandre, A., Frisullo, G., Di Egidio, V., Puglielli, E. G., Ruggero, L., Assetta, M., Casalena, A., Cester, G., Baracchini, C., Viaro, F., Pieroni, A., Vaudano, G., Comelli, C., Di Maggio, L., Castellano, D., Cavallo, R., Duc, E., Chianale, G., Ciceri, E. F. M., Plebani, M., Augelli, R., Zampieri, P., Grazioli, A., Cappellari, M., Forlivesi, S., Tomelleri, G., Micheletti, N., Chiumarulo, L., Zimatore, D. S., Federico, F., Petruzzelli, M., Zappoli, F., Lafe, E., Sanfilippo, G., Sgreccia, A., Martignoni, A., Cavallini, A., Denaro, F., Persico, A., Cagliari, E., Cavasin, N., Quatrale, R., Critelli, A., Burdi, N., Semeraro, V., Lucarelli, N., Ganimede, M. P., Internò, S., Tinelli, A., Prontera, M. P., Pesare, A., Cotroneo, E., Pampana, E., Ricciardi, F., Gigli, R., Pezzella, F. R., Corsi, F., Giorgianni, A., Baruzzi, F., Pellegrino, C., Terrana, A., Versino, M., Delodovici, M. L., Carimati, F., Cariddi, L. Princiotta, Auteri, W., Di Benedetto, O., Silvagni, U., Perrotta, P., Crispino, E., Petrone, A., Stancati, F., Rizzuto, S., Pugliese, P., Pisani, E., Siniscalchi, A., Gaudiano, C., Pirritano, D., Del Giudice, F., Piano, M., Agostoni, E., Motto, C., Gatti, A., Guccione, A., Tortorella, R., Stecco, A., Guzzardi, G., Del Sette, B., Coppo, L., Baldan, J., Romano, D., Siani, A., Locatelli, G., Saponiero, R., Napolitano, R., De Gregorio, M., Volpe, G., Tenuta, M., Guidetti, G., Biraschi, F., Wulbek, A., Falcou, A., Anzini, A., Mancini, A., De Michele, M., Fausti, S., Di Mascio, M. T., Durastanti, L., Sbardella, E., Mellina, V., Nicolini, E., Comelli, S., Ganau, C., Corraine, S., Fusaro, F., Ferrari, A., Schirru, F., Ledda, V., Secci, S., Melis, M., Piras, V., Moller, J., Padolecchia, R., Allegretti, L., Caldiera, V., Calia, S., Ganci, G., Tassinari, T., Sugo, A., De Nicola, M., Giannoni, M., Bruni, S., Gambelli, E., Provinciali, L., Nuzzi, N. P., Marcheselli, S., Corato, M., Scomazzoni, F., Simionato, F., Roveri, L., Filauri, P., Sacco, S., Orlandi, B., De Santis, F., Tiseo, C., Notturno, F., Ornello, R., Pavia, M., Squassina, G., Cobelli, M., Morassi, M., Magni, E., Invernizzi, P., Pepe, F., Bigni, B., Costa, P., Crabbio, M., Griffini, S., Palmerini, F., Piras, M. P., Gallesio, I., Barbero, S., Ferrandi, D., Dui, G., Fancello, M. C., Zedda, S., Ticca, A., Saddi, M. V., Deiana, G., Rossi, R., Carboni, N., Mela, A., Amistà, P., Russo, M., Iannucci, G., Pinna, V., Di Clemente, L., Santi, M., De Boni, A., De Luca, C., Natrella, M., Fanelli, G., Cristoferi, M., Bottacchi, E., Corso, G., Tosi, P., Sessa, M., Giossi, A., Baietti, Null, Romano, G., Meineri, P., Armentano, A., Versace, P., Arcudi, L., Galvano, G., Petralia, B., Feraco, P., Luppi, G., Giometto, B., Bignamini, V., Piffer, S., Meloni, G. B., Fabio, C., Maiore, M., Pintus, F., Pischedda, A., Manca, A., Mongili, C., Zanda, B., Baule, A., Florio, F., Ciccarese, G., Leone, M., Di Viesti, P., Pappalardo, M. P., Craparo, G., Gallo, C., Monaco, S., Mannino, M., Muto, M., Guarnieri, Gl., Andreone, V., Passalacqua, G., Allegritti, M., Caproni, S., Filizzolo, M., Salmaggi, A., Giordano, A., Marini, C., Frattale, I., Lucente, G., Nozzoli, C., and Lupo, F. A.
Subjects: Stent, Acute stroke, Settore MED/37 - Neuroradiologia, Acute stroke Internal carotid artery diseases Stent Thrombectomy, Neurology (clinical), General Medicine, Settore MED/26, Internal carotid artery diseases, Thrombectomy
Abstract: The management of tandem extracranial internal carotid artery and intracranial large vessel occlusion during endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) has been under-investigated. We sought to investigate outcomes of AIS patients with tandem occlusion (TO) treated with carotid artery stenting (CAS) compared to those not treated with CAS (no-CAS) during EVT.We performed a cohort study using data from AIS patients enrolled in the Italian Registry of Endovascular Treatment in Acute Stroke. Outcomes were 3 months' mortality, functional outcome, complete and successful recanalization, any intracranial hemorrhage, parenchymal hematoma and symptomatic intracerebral hemorrhage.Among 466 AIS patients with TO, CAS patients were 122 and no-CAS patients were 226 (118 excluded). After adjustment for unbalanced variables, CAS was associated with a lower rate of 3 months' mortality (OR 0.407, 95% CI 0.171-0.969, p = 0.042). After adjustment for pre-defined variables, CAS was associated with a lower rate of 3 months' mortality (aOR 0.430, 95% CI 0.187-0.989, p = 0.047) and a higher rate of complete recanalization (aOR 1.986, 95% CI 1.121-3.518, p = 0.019), successful recanalization (aOR 2.433, 95% CI 1.263-4.686, p = 0.008) and parenchymal hematoma (aOR 2.876, 95% CI 1.173-7.050, p = 0.021). CAS was associated with lower 3 months mortality (OR 0.373, 95% CI 0.141-0.982, p = 0.046) and higher rates of successful recanalization (OR 2.082, 95% CI 1.099-3.942, p = 0.024) after adjustment for variables associated with 3 months' mortality and successful recanalization, respectively.Among AIS patients with TO, CAS during EVT was associated with a higher rate of successful reperfusion and a lower rate of 3 months' mortality.
Published: 2022

11. Imaging of the Muscle in Idiopathic Inflammatory Myopathies

Author: Filosto, M., Paoletti, M., Padovani, A., Gasparotti, R., and Pichiecchio, A.
Published: 2022

12. The brain in late-onset glycogenosis II: a structural and functional MRI study

Author: Borroni, Barbara, Cotelli, M. S., Premi, E., Gazzina, S., Cosseddu, M., Formenti, A., Gasparotti, R., Filosto, M., and Padovani, A.
Published: 2013
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13. Abnormal pain perception is associated with thalamo-cortico-striatal atrophy in C9orf72 expansion carriers in the GENFI cohort

Author: Convery, Rhian S, Bocchetta, Martina, Masellis, Mario, Afonso, S., Taipa, R., Caroppo, P., Di Fede, G., Giaccone, G., Prioni, S., Redaelli, V., Rossi, G., Tiraboschi, P., Duro, D., Tartaglia, Maria Carmela, Almeida, M. R., Branco, M. C., Leitão, M. J., Tabuas-Pereira, M., Santiago, B., Gauthier, S., Rosa-Neto, P., Veldsman, M., Flanagan, T., Prix, C., Graff, Caroline, Hoegen, T., Wlasich, E., Loosli, S., Schonecker, S., Semler, E., Anderl-Straub, S., Galimberti, Daniela, Rowe, James B, Finger, Elizabeth, Synofzik, Matthis, Vandenberghe, Rik, de Mendonca, Alexandre, Tagliavini, Fabrizio, Greaves, Caroline V, Santana, Isabel, Ducharme, Simon, Butler, Christopher, Gerhard, Alex, Levin, Johannes, Danek, Adrian, Otto, Markus, Warren, Jason D, Rohrer, Jonathan D, Initiative, Genetic FTD, Moore, Katrina M, Rossor, M. N., Fox, N. C., Woollacott, I. O. C., Shafei, R., Heller, C., Peakman, G., Swift, I., Todd, E., Guerreiro, R., Bras, J., Cash, David M, Thomas, D. L., Nicholas, J., Mead, S., Jiskoot, L., Meeter, L., Panman, J., Papma, J., van Minkelen, R., Pijnenburg, Y., Barandiara, M., Van Swieten, John, Indakoetxea, B., Gabilondo, A., Tainta, M., de Arriba, M., Gorostidi, A., Zulaica, M., Villanua, J., Diaz, Z., Borrego-Ecija, S., Olives, J., Moreno, Fermin, Lladó, A., Balasa, M., Antonell, A., Bargallo, N., Premi, E., Cosseddu, M., Gazzina, S., Padovani, A., Gasparotti, R., Archetti, S., Sánchez-Valle, Raquel, Black, S., Mitchell, S., Rogaeva, E., Freedman, M., Keren, R., Tang-Wai, D., Öijerstedt, L., Andersson, C., Jelic, V., Thonberg, H., Borroni, Barbara, Arighi, A., Fenoglio, C., Scarpini, E., Fumagalli, G., Cope, T., Timberlake, C., Rittman, T., Shoesmith, C., Bartha, R., Rademakers, R., Laforce, Robert, Wilke, C., Karnarth, H-O, Bender, B., Bruffaerts, R., Vandamme, P., Vandenbulcke, M., Ferreira, C. B., Miltenberger, G., Maruta, C., Verdelho, A., Convery, Rhian S [0000-0002-9477-1812], Bocchetta, Martina [0000-0003-1814-5024], Greaves, Caroline V [0000-0002-6446-1960], Moore, Katrina M [0000-0002-4458-8390], Van Swieten, John [0000-0001-6278-6844], Borroni, Barbara [0000-0001-9340-9814], Rowe, James B [0000-0001-7216-8679], Finger, Elizabeth [0000-0003-4461-7427], Otto, Markus [0000-0002-6647-5944], Rohrer, Jonathan D [0000-0002-6155-8417], Apollo - University of Cambridge Repository, Neurology, and Repositório da Universidade de Lisboa
Subjects: Male, diagnostic imaging [Corpus Striatum], Medizin, Somatosensory system, physiopathology [Frontotemporal Dementia], frontotemporal dementia, Cohort Studies, genetics [Progranulins], 0302 clinical medicine, Progranulins, Thalamus, C9orf72, Cerebellum, diagnostic imaging [Cerebral Cortex], pathology [Cerebellum], Medicine, pain, genetics [Frontotemporal Dementia], Cerebral Cortex, 0303 health sciences, DNA Repeat Expansion, Pain Perception, Middle Aged, Magnetic Resonance Imaging, Temporal Lobe, Psychiatry and Mental health, Cohort, diagnostic imaging [Prefrontal Cortex], Female, Frontotemporal dementia, genetics [Atrophy], Adult, medicine.medical_specialty, pathology [Corpus Striatum], Pain, Prefrontal Cortex, genetics [Perceptual Disorders], MAPT protein, human, tau Proteins, diagnostic imaging [Frontotemporal Dementia], Temporal lobe, Perceptual Disorders, 03 medical and health sciences, Atrophy, pathology [Thalamus], Internal medicine, Humans, ddc:610, genetics [C9orf72 Protein], 030304 developmental biology, diagnostic imaging [Perceptual Disorders], Aged, diagnostic imaging [Thalamus], C9orf72 Protein, business.industry, pathology [Temporal Lobe], diagnostic imaging [Atrophy], physiopathology [Atrophy], medicine.disease, diagnostic imaging [Cerebellum], pathology [Prefrontal Cortex], Corpus Striatum, physiopathology [Perceptual Disorders], genetics [tau Proteins], diagnostic imaging [Temporal Lobe], Logistic Models, Asymptomatic Diseases, Mutation, GRN protein, human, Surgery, Orbitofrontal cortex, pathology [Cerebral Cortex], Neurology (clinical), C9orf72 protein, human, business, 030217 neurology & neurosurgery
Abstract: © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. published by BMJ., Objective: Frontotemporal dementia (FTD) is typically associated with changes in behaviour, language and movement. However, recent studies have shown that patients can also develop an abnormal response to pain, either heightened or diminished. We aimed to investigate this symptom in mutation carriers within the Genetic FTD Initiative (GENFI). Methods: Abnormal responsiveness to pain was measured in 462 GENFI participants: 281 mutation carriers and 181 mutation-negative controls. Changes in responsiveness to pain were scored as absent (0), questionable or very mild (0.5), mild (1), moderate (2) or severe (3). Mutation carriers were classified into C9orf72 (104), GRN (128) and MAPT (49) groups, and into presymptomatic and symptomatic stages. An ordinal logistic regression model was used to compare groups, adjusting for age and sex. Voxel-based morphometry was performed to identify neuroanatomical correlates of abnormal pain perception. Results: Altered responsiveness to pain was present to a significantly greater extent in symptomatic C9orf72 expansion carriers than in controls: mean score 0.40 (SD 0.71) vs 0.00 (0.04), reported in 29% vs 1%. No significant differences were seen between the other symptomatic groups and controls, or any of the presymptomatic mutation carriers and controls. Neural correlates of altered pain perception in C9orf72 expansion carriers were the bilateral thalamus and striatum as well as a predominantly right-sided network of regions involving the orbitofrontal cortex, inferomedial temporal lobe and cerebellum. Conclusion: Changes in pain perception are a feature of C9orf72 expansion carriers, likely representing a disruption in somatosensory, homeostatic and semantic processing, underpinned by atrophy in a thalamo-cortico-striatal network.
Published: 2020

14. Three-dimensional MR angiography in the study of intracranial neoplasms

Author: Gasparotti, R., Gualandi, G. F., Orlandini, A., Chiesa, A., du Boulay, George, editor, Molyneux, Andrew, editor, and Moseley, Ivan, editor
Published: 1991
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15. Analysis of brain atrophy and local gene expression in genetic frontotemporal dementia

Author: Altmann, A., Cash, D. M., Bocchetta, M., Heller, C., Reynolds, R., Moore, K., Convery, R. S., Thomas, D. L., Van Swieten, J. C., Moreno, F., Sanchez-Valle, R., Borroni, B., Laforce, R., Masellis, M., Tartaglia, M. C., Graff, C., Galimberti, D., Rowe, J. B., Finger, E., Synofzik, M., Vandenberghe, R., De Mendonca, A., Tagliavini, F., Santana, I., Ducharme, S., Butler, C. R., Gerhard, A., Levin, J., Danek, A., Frisoni, G., Ghidoni, R., Sorbi, S., Otto, M., Ryten, M., Rohrer, J. D., Greaves, C., Peakman, G., Shafei, R., Todd, E., Rossor, M. N., Warren, J. D., Fox, N. C., Zetterberg, H., Guerreiro, R., Bras, J., Nicholas, J., Mead, S., Jiskoot, L., Meeter, L., Panman, J., Papma, J. M., Van Minkelen, R., Pijnenburg, Y., Barandiaran, M., Indakoetxea, B., Gabilondo, A., Tainta, M., De Arriba, M., Gorostidi, A., Zulaica, M., Villanua, J., Diaz, Z., Borrego-Ecija, S., Olives, J., Llado, A., Balasa, M., Antonell, A., Bargallo, N., Premi, E., Cosseddu, M., Gazzina, S., Padovani, A., Gasparotti, R., Archetti, S., Black, S., Mitchell, S., Rogaeva, E., Freedman, M., Keren, R., Tang-Wai, D., Oijerstedt, L., Andersson, C., Jelic, V., Thonberg, H., Arighi, A., Fenoglio, C., Scarpini, E., Fumagalli, G., Cope, T., Timberlake, C., Rittman, T., Shoesmith, C., Bartha, R., Rademakers, R., Wilke, C., Karnarth, H. -O., Bender, B., Bruffaerts, R., Van Damme, P., Vandenbulcke, M., Ferreira, C. B., Miltenberger, G., Maruta, C., Verdelho, A., Afonso, S., Taipa, R., Caroppo, P., Di Fede, G., Giaccone, G., Prioni, S., Redaelli, V., Rossi, G., Tiraboschi, P., Duro, D., Almeida, M. R., Castelo-Branco, M., Leitao, M. J., Tabuas-Pereira, M., Santiago, B., Gauthier, S., Rosa-Neto, P., Veldsman, M., Thompson, P., Langheinrich, T., Prix, C., Hoegen, T., Wlasich, E., Loosli, S., Schonecker, S., Semler, E., Anderl-Straub, S., Benussi, L., Binetti, G., Pievani, M., Lombardi, G., Nacmias, B., Ferrari, C., Bessi, V., Polito, C., Rowe, James [0000-0001-7216-8679], Apollo - University of Cambridge Repository, Medical Research Council, and Genetic FTD Initiative, GENFI
Subjects: 0301 basic medicine, Cell type, Imaging genetics, Clinical Neurology, Medizin, Biology, Article, DISEASE, 03 medical and health sciences, 0302 clinical medicine, Atrophy, atrophy, C9orf72, Gene expression, medicine, Astrocytes, Frontotemporal dementia, ddc:610, 10. No inequality, Gene, 030304 developmental biology, Genetics, 0303 health sciences, Science & Technology, TREM2, AcademicSubjects/SCI01870, Neurodegeneration, General Engineering, C9orf72 Gene, Neurosciences, astrocytes, Genetic FTD Initiative, GENFI, medicine.disease, C9orf72 Protein, 030104 developmental biology, gene expression, imaging genetics, Original Article, AcademicSubjects/MED00310, Human medicine, Neurosciences & Neurology, Life Sciences & Biomedicine, 030217 neurology & neurosurgery
Abstract: Frontotemporal dementia is a heterogeneous neurodegenerative disorder characterized by neuronal loss in the frontal and temporal lobes. Despite progress in understanding which genes are associated with the aetiology of frontotemporal dementia, the biological basis of how mutations in these genes lead to cell loss in specific cortical regions remains unclear. In this work, we combined gene expression data for 16 772 genes from the Allen Institute for Brain Science atlas with brain maps of grey matter atrophy in symptomatic C9orf72, GRN and MAPT mutation carriers obtained from the Genetic Frontotemporal dementia Initiative study. No significant association was seen between C9orf72, GRN and MAPT expression and the atrophy patterns in the respective genetic groups. After adjusting for spatial autocorrelation, between 1000 and 5000 genes showed a negative or positive association with the atrophy pattern within each individual genetic group, with the most significantly associated genes being TREM2, SSBP3 and GPR158 (negative association in C9Orf72, GRN and MAPT respectively) and RELN, MXRA8 and LPA (positive association in C9Orf72, GRN and MAPT respectively). An overrepresentation analysis identified a negative association with genes involved in mitochondrial function, and a positive association with genes involved in vascular and glial cell function in each of the genetic groups. A set of 423 and 700 genes showed significant positive and negative association, respectively, with atrophy patterns in all three maps. The gene set with increased expression in spared cortical regions was enriched for neuronal and microglial genes, while the gene set with increased expression in atrophied regions was enriched for astrocyte and endothelial cell genes. Our analysis suggests that these cell types may play a more active role in the onset of neurodegeneration in frontotemporal dementia than previously assumed, and in the case of the positively associated cell marker genes, potentially through emergence of neurotoxic astrocytes and alteration in the blood–brain barrier, respectively., Altmann et al. investigated the concordance between spatial cortical gene expression in healthy subjects and atrophy patterns in genetic frontotemporal dementia. They found that elevated gene expression of endothelial cell and astrocyte-related genes in regions with atrophy, suggesting a role of these cell types in the aetiology of frontotemporal dementia., Graphical Abstract Graphical Abstract
Published: 2020

16. Endovascular Thrombectomy for Acute Ischemic Stroke beyond 6 Hours from Onset: A Real-World Experience

Author: Casetta, I., Fainardi, E., Saia, V., Pracucci, G., Padroni, M., Renieri, L., Nencini, P., Inzitari, D., Morosetti, D., Sallustio, F., Vallone, S., Bigliardi, G., Zini, A., Longo, M., Francalanza, I., Bracco, S., Vallone, I. M., Tassi, R., Bergui, M., Naldi, A., Saletti, A., De Vito, A., Gasparotti, R., Magoni, M., Castellan, L., Serrati, C., Menozzi, R., Scoditti, U., Causin, F., Pieroni, A., Puglielli, E., Casalena, A., Sanna, A., Ruggiero, M., Cordici, F., Di Maggio, L., Duc, E., Cosottini, M., Giannini, N., Sanfilippo, G., Zappoli, F., Toni, D., Cavasin, N., Critelli, A., Ciceri, E., Plebani, M., Cappellari, M., Chiumarulo, L., Petruzzellis, M., Terrana, A., Cariddi, L. P., Burdi, N., Tinelli, A., Auteri, W., Silvagni, U., Biraschi, F., Nicolini, E., Padolecchia, R., Tassinari, T., Filauri, P., Sacco, S., Pavia, M., Invernizzi, P., Nuzzi, N. P., Marcheselli, S., Amista, P., Russo, M., Gallesio, I., Craparo, G., Mannino, M., and Mangiafico, S.
Subjects: Male, medicine.medical_specialty, Middle Cerebral Artery, Time Factors, cerebral blood volume, collateral circulation, groin, intracranial hemorrhage, middle cerebral artery, thrombectomy, Ischemia, Brain Ischemia, Brain ischemia, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine.artery, medicine, Humans, 030212 general & internal medicine, Acute ischemic stroke, Stroke, Aged, Advanced and Specialized Nursing, medicine.diagnostic_test, Groin, business.industry, Endovascular Procedures, Ambientale, Middle Aged, medicine.disease, Collateral circulation, Intracranial Hemorrhages/*surgery Ischemia/surgery Male Middle Aged Middle Cerebral Artery/physiopathology/surgery Stroke/*surgery Thrombectomy/methods Time Factors cerebral blood volume collateral circulation, Cerebral Angiography, medicine.anatomical_structure, Middle cerebral artery, Cardiology, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, Intracranial Hemorrhages, 030217 neurology & neurosurgery, Thrombectomy, Cerebral angiography
Abstract: Background and Purpose: To evaluate outcome and safety of endovascular treatment beyond 6 hours of onset of ischemic stroke due to large vessel occlusion in the anterior circulation, in routine clinical practice. Methods: From the Italian Registry of Endovascular Thrombectomy, we extracted clinical and outcome data of patients treated for stroke of known onset beyond 6 hours. Additional inclusion criteria were prestroke modified Rankin Scale score ≤2 and ASPECTS score ≥6. Patients were selected on individual basis by a combination of CT perfusion mismatch (difference between total hypoperfusion and infarct core sizes) and CT collateral score. The primary outcome measure was the score on modified Rankin Scale at 90 days. Safety outcomes were 90-day mortality and the occurrence of symptomatic intracranial hemorrhage. Data were compared with those from patients treated within 6 hours. Results: Out of 3057 patients, 327 were treated beyond 6 hours. Their mean age was 66.8±14.9 years, the median baseline National Institutes of Health Stroke Scale 16, and the median onset to groin puncture time 430 minutes. The most frequent site of occlusion was middle cerebral artery (45.1%). Functional independence (90-day modified Rankin Scale score, 0–2) was achieved by 41.3% of cases. Symptomatic intracranial hemorrhage occurred in 6.7% of patients, and 3-month case fatality rate was 17.1%. The probability of surviving with modified Rankin Scale score, 0–2 (odds ratio, 0.58 [95% CI, 0.43–0.77]) was significantly lower in patients treated beyond 6 hours as compared with patients treated earlier No differences were found regarding recanalization rates and safety outcomes between patients treated within and beyond 6 hours. There were no differences in outcome between people treated 6-12 hours from onset (278 patients) and those treated 12 to 24 hours from onset (49 patients). Conclusions: This real-world study suggests that in patients with large vessel occlusion selected on the basis of CT perfusion and collateral circulation assessment, endovascular treatment beyond 6 hours is feasible and safe with no increase in symptomatic intracranial hemorrhage.
Published: 2020

17. Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy

Author: Padovani, A., Borroni, B., Brambati, S.M., Agosti, C., Broli, M., Alonso, R., Scifo, P., Bellelli, G., Alberici, A., Gasparotti, R., and Perani, D.
Subjects: Progressive supranuclear palsy -- Physiological aspects, Progressive supranuclear palsy -- Research, Health, Psychology and mental health
Published: 2006

18. Clinical and radiological features of posterior cortical atrophy (PCA) in a GRN mutation carrier: a case report

Author: Giunta, M., primary, Libri, I., additional, Premi, E., additional, Brattini, C., additional, Paghera, B., additional, Archetti, S., additional, Gasparotti, R., additional, Padovani, A., additional, Borroni, B., additional, and Benussi, A., additional
Published: 2020
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19. Sex-specific associations between early-life exposure to manganese and white matter microstructure in adolescents and young adults

Author: Rechtman, E., primary, Curtin, P., additional, Papazaharias, D., additional, de Water, E., additional, Navarro, E., additional, Ambrosi, C., additional, Mascaro, L., additional, Gasparotti, R., additional, Austin, C., additional, Arora, M., additional, Smith, D.R., additional, Wright, R.O., additional, Tang, C.Y., additional, Lucchini, R.G., additional, and Horton, M.K., additional
Published: 2020
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20. Sex-specific associations between early life exposure to manganese and intrinsic functional connectivity of the brain in adolescents and young adults

Author: Rechtman, E., primary, Navarro, E., additional, de Water, E., additional, Papazaharias, D.M., additional, Curtin, P., additional, Ambrosi, C., additional, Mascaro, L., additional, Gasparotti, R., additional, Austin, C., additional, Arora, M., additional, Smith, D.R., additional, Wright, R.O., additional, Tang, C.Y., additional, Lucchini, R.G., additional, and Horton, M.K., additional
Published: 2020
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21. Functional and radiological outcomes after bridging therapy versus direct thrombectomy in stroke patients with unknown onset

Author: Cappellari, M., primary, Saia, V., additional, Pracucci, G., additional, Sallustio, F., additional, Gandini, R., additional, Nappini, S., additional, Nencini, P., additional, Vallone, S., additional, Zini, A., additional, Bigliardi, G., additional, Granata, F., additional, Grillo, F., additional, Cioni, S., additional, Tassi, R., additional, Bergui, M., additional, Cerrato, P., additional, Saletti, A., additional, De Vito, A., additional, Gasparotti, R., additional, Magoni, M., additional, Taglialatela, F., additional, Ruggiero, M., additional, Longoni, M., additional, Castellan, L., additional, Malfatto, L., additional, Menozzi, R., additional, Castellini, P., additional, Cosottini, M., additional, Mancuso, M., additional, Comai, A., additional, Franchini, E., additional, Lozupone, E., additional, Della Marca, G., additional, Ciceri, E. F. M., additional, Bonetti, B., additional, Zampieri, P., additional, Inzitari, D., additional, Mangiafico, S., additional, and Toni, D., additional
Published: 2020
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22. Steroid-responsive encephalitis in Covid-19 disease

Author: Pilotto, Andrea, primary, Odolini, Silvia, additional, Masciocchi S, Stefano, additional, Comelli, Agnese, additional, Volonghi, Irene, additional, Gazzina, Stefano, additional, Nocivelli, Sara, additional, Pezzini, Alessandro, additional, Focà, Emanuele, additional, Caruso, Arnaldo, additional, Leonardi, Matilde, additional, Pasolini, Maria Pia, additional, Gasparotti R, Roberto, additional, Castelli F, Francesco, additional, Ashton, Nicholas J., additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, and Padovani, Alessandro, additional
Published: 2020
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23. A challenging diagnosis of reversible “vascular” dementia: Cerebral amyloid angiopathy-related inflammation

Author: Poli, L., primary, De Giuli, V., additional, Piazza, F., additional, Volonghi, I., additional, Bigliardi, G., additional, Vallone, S., additional, Nichelli, P.F., additional, Gasparotti, R., additional, Zini, A., additional, Padovani, A., additional, and Pezzini, A., additional
Published: 2020
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24. Intra-arterial or intravenous thrombolysis for acute ischemic stroke? The SYNTHESIS pilot trial

Author: Ciccone, A, Valvassori, L, Ponzio, M, Ballabio, E, Gasparotti, R, Sessa, M, Scomazzoni, F, Tiraboschi, P, and Sterzi, R
Published: 2010
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25. Joubert syndrome with bilateral polymicrogyria: Clinical and neuropathological findings in two brothers

Author: Giordano, L., Vignoli, A., Pinelli, L., Brancati, F., Accorsi, P., Faravelli, F., Gasparotti, R., Granata, T., Giaccone, G., Inverardi, F., Frassoni, C., Dallapiccola, B., Valente, E. M., and Spreafico, R.
Published: 2009
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26. Neurobiological and clinical effect of metacognitive interpersonal therapy vs structured clinical model: study protocol for a randomized controlled trial

Author: Magni, LAURA ROSA, Carcione, Antonino, Ferrari, Clarissa, Semerari, Antonio, Riccardi, Ilaria, Nicolo', Giuseppe, Lanfredi, Mariangela, Pedrini, Laura, Cotelli, Maria, Bocchio, Luisella, Pievani, Michela, Gasparotti, Roberto, Rossi, Roberta, Rossi, R, Magni, Lr, Lanfredi, M, Pedrini, L, Carcione, A, Semerari, A, Riccardi, I, Nicolo', G, Almici, M, Beneduce, R, Borsci, G, Caprioli, C, Nodari, M, Vita, A, Barlati, S, Laffranchini, L, Rillosi, L, Rossi, G, Bocchio, L, Cattaneo, A, Cattane, N, Tura, Gb, Bignotti, S, Speziali, M, Cotelli, M, Rosini, S, Gasparotti, R, Ambrosi, C, Mascaro, L, Corbo, D, Pievani, M, Quattrini, G, Bilotta, E, Colle, L, Conti, L, Fiore, D, Micheloni, A, Procacci, M, and Silvestre, V.
Subjects: Adult, Male, Adolescent, lcsh:RC435-571, Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA, medicine.medical_treatment, Neuroimaging, Impulsivity, law.invention, Study Protocol, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Alexithymia, law, Emotionality, lcsh:Psychiatry, mental disorders, medicine, Humans, 030212 general & internal medicine, Borderline personality disorder, Interpersonal Psychotherapy, Emotion dysregulation, Metacognition, Psychotherapy, business.industry, Borderline Personality Disorder, Female, Middle Aged, Treatment Outcome, medicine.disease, 030227 psychiatry, Clinical trial, Cognitive behavioral therapy, Psychiatry and Mental health, Adjunctive treatment, medicine.symptom, business, Clinical psychology
Abstract: Background Borderline Personality Disorder (BPD) is a complex and debilitating disorder, characterized by deficits in metacognition and emotion dysregulation. The “gold standard” treatment for this disorder is psychotherapy with pharmacotherapy as an adjunctive treatment to target state symptoms. The present randomized clinical trial aims to assess the clinical and neurobiological changes following Metacognitive Interpersonal Therapy (MIT) compared with Structured Clinical Management (SCM) derived from specific recommendations in APA (American Psychiatric Association) guidelines for BPD. Methods The study design is a randomized parallel controlled clinical trial and will include 80 BPD outpatients, aged 18–45 enrolled at 2 recruitment centers. Primary outcome will be the clinical change in emotion regulation capacities assessed with the Difficulties in Emotion Regulation Scale (DERS). We will also investigated the effect of psychotherapy on metacognitive abilities and several clinical features such as BPD symptomatology, general psychopathology, depression, personal functioning, and trait dimensions (anger, impulsivity, alexithymia). We will evaluate changes in brain connectivity patterns and during the view of emotional pictures. A multidimensional assessment will be performed at the baseline, at 6, 12, 18 months. We will obtain structural and functional Magnetic Resonance Images (MRIs) in MIT-Treated BPD (N = 30) and SCM-treated BPD (N = 30) at baseline and after treatment, as well as in a group of 30 healthy and unrelated volunteers that will be scanned once for comparison. Discussion The present study could contribute to elucidate the neurobiological mechanisms underlying psychotherapy efficacy. The inclusion of a multidisciplinary study protocol will allow to study BPD considering different features that can affect the treatment response and their reciprocal relationships. Trial registration NCT02370316. Registered 02/24/2015. Electronic supplementary material The online version of this article (10.1186/s12888-019-2127-2) contains supplementary material, which is available to authorized users.
Published: 2019

27. Combined intravenous and endovascular treatment versus primary mechanical thrombectomy. The Italian Registry of Endovascular Treatment in Acute Stroke

Author: Casetta, I, Pracucci, G, Saletti, A, Saia, V, Padroni, M, De Vito, A, Inzitari, D, Zini, A, Vallone, S, Bergui, M, Cerrato, P, Bracco, S, Tassi, R, Gandini, R, Sallustio, F, Piano, M, Motto, C, Spina, P, Vinci, Sl, Causin, F, Baracchini, C, Gasparotti, R, Magoni, M, Castellan, L, Serrati, C, Mangiafico, S, Toni, D, and The Italian Registry of Endovascular Treatment in Acute Stroke
Subjects: Brain Infarction, Male, medicine.medical_specialty, medicine.medical_treatment, Stroke/therapy, Fibrinolytic Agents, 80 and over, medicine, ischemic stroke, Humans, Aged, 80 and over, Endovascular procedures, Thrombolytic Therapy, intravenous thrombolysis, Registries, acute stroke therapy, thrombectomy, Endovascular treatment, Stroke, Acute stroke therapy, Cerebral infarction, Intravenous thrombolysis, iIchemic stroke, Thrombectomy, Stroke, Aged, Acute stroke, Cerebral infarction, business.industry, Ambientale, Thrombolysis, Middle Aged, medicine.disease, cerebral infarction, Combined Modality Therapy, Surgery, Mechanical thrombectomy, Treatment Outcome, Italy, Neurology, Ischemic stroke, Female, business
Abstract: Background Whether mechanical thrombectomy alone may achieve better or at least equal clinical outcome than mechanical thrombectomy combined with intravenous thrombolysis is a matter of debate. Methods From the Italian Registry of Endovascular Stroke Treatment, we extracted all cases treated with intravenous thrombolysis followed by mechanical thrombectomy or with primary mechanical thrombectomy for anterior circulation stroke due to proximal vessel occlusion. We included only patients who would have qualified for intravenous thrombolysis. We compared outcomes of the two groups by using multivariate regression analysis and propensity score method. Results We included 1148 patients, treated with combined intravenous thrombolysis and mechanical thrombectomy therapy (n = 635; 55.3%), or with mechanical thrombectomy alone (n = 513; 44.7%). Demographic and baseline clinical characteristics did not differ between the two groups, except for a shorter onset to groin puncture time (p Conclusion These data seem to indicate that combined intravenous thrombolysis and mechanical thrombectomy could be associated with lower probability of death or severe dependency after three months from stroke due to large vessel occlusion, supporting the current guidelines of treating eligible patients with intravenous thrombolysis before mechanical thrombectomy.
Published: 2019

28. PERINATAL OUTCOME AND NEUROLOGICAL FOLLOW UP OF TWIN PREGNANCIES COMPLICATED BY SINGLE FETAL INTRAUTERINE DEATH

Author: Fichera, A, Zambolo, C, Andrico, S, Minelli, A, Ambrosi, C, Gasparotti, R, Accorsi, P, and Frusca, T
Published: 2007

29. Giant congenital nevus and chronic progressive ascending hemiparesis (Mills syndrome). Report of a case

Author: Frisoni G. B., Gasparotti R., and Di Monda V.
Published: 1992
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30. 245. A protocol set-up for fast brain T1 mapping of subcortical tissues

Author: Belligotti, E., primary, Mascaro, L., additional, Ambrosi, C., additional, Pinardi, C., additional, Reali, M., additional, Lucchini, R., additional, Tang, C. Ying, additional, and Gasparotti, R., additional
Published: 2018
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31. 22. Multicentric test-retest reproducibility of human hippocampal volumes with FreeSurfer 6.0: A comparison between standard and longitudinal hippocampal subfields segmentation streams applied to 3D T1, 3D FLAIR and high-resolution 2D T2 neuroimaging

Author: Chiappiniello, A., primary, Tarducci, R., additional, Muscio, C., additional, Frisoni, G.B., additional, Bruzzone, M.G., additional, Bozzali, M., additional, Perani, D., additional, Tiraboschi, P., additional, Nigri, A., additional, Ambrosi, C., additional, Caulo, M., additional, Chipi, E., additional, Chiti, S., additional, Fainardi, E., additional, Ferraro, S., additional, Festari, C., additional, Gasparotti, R., additional, Ginestroni, A., additional, Giulietti, G., additional, Mascaro, L., additional, Navarra, R., additional, Nicolosi, V., additional, Parnetti, L., additional, Rosazza, C., additional, Serra, L., additional, Tagliavini, F., additional, and Jovicich, J., additional
Published: 2018
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32. 243. Performance comparison of head RF multicoil array: What are the advantages of increasing coil numbers?

Author: Mascaro, L., primary, Ambrosi, C., additional, Pinardi, C., additional, Belligotti, E., additional, Moretti, R., additional, Forcella, F.G., additional, and Gasparotti, R., additional
Published: 2018
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33. Ischaemic pontomedullary transection with incomplete locked-in syndrome: A case report with MRI

Author: Latronico, N., Tansini, A., Gualandi, G. F., Gasparotti, R., Bochicchio, M., Chiesa, A., and Candiani, A.
Published: 1993
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34. Clinical and radiological features of posterior cortical atrophy (PCA) in a GRN mutation carrier: a case report.

Author: Giunta, M., Libri, I., Premi, E., Brattini, C., Paghera, B., Archetti, S., Gasparotti, R., Padovani, A., Borroni, B., and Benussi, A.
Subjects: CEREBRAL atrophy, CEREBROSPINAL fluid examination, NEUROLOGIC examination, NEUROPSYCHOLOGICAL tests, ALZHEIMER'S disease, SPINOCEREBELLAR ataxia
Abstract: Background and purpose: Posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome, defined by a distinctive clinical‐radiological profile, with Alzheimer's disease (AD) pathology accounting for the majority of cases. The aim of this report was to present the case of a patient with impairment of visual and constructional abilities as initial manifestations. Method: The patient underwent a multidimensional assessment, including neuropsychological evaluation, structural and functional imaging and genetic screening. Results: Neurological and neuropsychological assessment showed an impairment of constructive and visuo‐spatial skills, associated with dyscalculia, simultanagnosia, optic ataxia and oculomotor apraxia. In accordance with the latest consensus criteria, a diagnosis of PCA was made. Consistent with the clinical findings, structural and functional imaging showed a peculiar pattern of atrophy with primary involvement of right parieto‐occipital cortices, whereas cerebrospinal fluid biochemical analysis did not reveal a profile compatible with AD pathology. Genetic screening identified a known pathogenic GRN mutation. Conclusion: We present a case of PCA in a GRN mutation carrier in whom a concomitant AD pathological process was excluded. Consequently, although lacking histological data, our case suggests GRN‐related pathology causative of PCA. Through this report we provide further evidence for a new neurodegenerative pathway leading to PCA, extending the clinical spectrum of GRN‐associated phenotypes. [ABSTRACT FROM AUTHOR]
Published: 2021
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35. Functional and radiological outcomes after bridging therapy versus direct thrombectomy in stroke patients with unknown onset: Bridging therapy versus direct thrombectomy in unknown onset stroke patients with 10‐point ASPECTS.

Author: Cappellari, M., Saia, V., Pracucci, G., Sallustio, F., Gandini, R., Nappini, S., Nencini, P., Vallone, S., Zini, A., Bigliardi, G., Granata, F., Grillo, F., Cioni, S., Tassi, R., Bergui, M., Cerrato, P., Saletti, A., De Vito, A., Gasparotti, R., and Magoni, M.
Subjects: THROMBECTOMY, STROKE patients, INTRACEREBRAL hematoma, ENDOVASCULAR surgery, CEREBRAL hemorrhage, PROPENSITY score matching
Abstract: Background and purpose: The aim was to assess functional and radiological outcomes after bridging therapy (intravenous thrombolysis plus mechanical thrombectomy) versus direct mechanical thrombectomy (MT) in unknown onset stroke patients. Methods: A cohort study was conducted on prospectively collected data from unknown onset stroke patients who received endovascular procedures at ≤6 h from symptom recognition or awakening time. Results: Of the 349 patients with a 10‐point Alberta Stroke Program Early Computed Tomography Score (ASPECTS), 248 received bridging and 101 received direct MT. Of the 134 patients with 6–9‐point ASPECTS, 123 received bridging and 111 received direct MT. Each patient treated with bridging was propensity score matched with a patient treated with direct MT for age, sex, study period, pre‐stroke disability, stroke severity, type of stroke onset, symptom recognition to groin time (or awakening to groin time), ASPECTS and procedure time. In the two matched groups with 10‐point ASPECTS (n = 73 vs. n = 73), bridging was associated with higher rates of excellent outcome (46.6% vs. 28.8%; odds ratio 2.302, 95% confidence interval 1.010–5.244) and successful recanalization (83.6% vs. 63%; odds ratio 3.028, 95% confidence interval 1.369–6.693) compared with direct MT; no significant association was found between bridging and direct MT with regard to rate of symptomatic intracerebral hemorrhage (0% vs. 1.4%). In the two matched groups with 6–9‐point ASPECTS (n = 45 vs. n = 45), no significant associations were found between bridging and direct MT with regard to rates of excellent functional outcome (44.4% vs. 31.1%), successful recanalization (73.3% vs. 76.5%) and symptomatic intracerebral hemorrhage (0% vs. 0%). Conclusions: Bridging at ≤ 6 h of symptom recognition or awakening time was associated with better functional and radiological outcomes in unknown onset stroke patients with 10‐point ASPECTS. [ABSTRACT FROM AUTHOR]
Published: 2021
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36. Transcranial Doppler Sonography and Magnetic Resonance Angiography in the Assessment of Collateral Hemispheric Flow in Patients With Carotid Artery Disease

Author: Anzola, G.P., Gasparotti, R., Magoni, M., and Prandini, F.
Published: 1995

37. Su Hegel e l'ebraismo

Author: Adinolfi, M., Bellantone, A., Benso, S., Bensussan, G., Cacciari, M., Cantillo, G., Carillo, G., Courtine, J. -. F., De Giovanni, B., Di Cesare, D., Di Tommaso, G., Donà, M., Duque, F., Esposito, R., Fabris, A., Ferrari, F., Forcellino, E., Forte, B., Gasparotti, R., Giorello, G., Goria, G., Lisciani-petrini, E., Mazzarella, E., Mirri, E., Moro, G., Petrarca, G., Rametta, G., Radaelli, E., Rocco Lonzano, V., Ronchi, R., Severino, E., Sini, C., Tagliapietra, A., Tarca, L. V., Tessitore, F., Tomatis, F., Trione, A., Valagussa, F., and Invrenizzi, C.
Subjects: antisemitismo, religione, ebraismo, Hegel, Hegel, religione, ebraismo, antisemitismo
Published: 2017

38. La lampada di Vitiello. Sulla potenza e sul possibile

Author: Adinolfi, M., Bellantone, A., Bensussan, G., Cacciari, M., Cantillo, G., Courtine, J. -. F., Carill, G., De Giovanni, B., Di Cesare, D., Di Tommaso, G., Donà, M., Duque, F., Fabris, A., Forcellino, E., Forte, B., Gasparotti, R., Giorello, G., Goria, G., LISCIANI PETRINI, Enrica, Mazzarella, E., Mirri, E., Moro, G., Petrarca, G., Rametta, G., Redaelli, E., Lozano, V., Ronchi, R., Severino, E., Sini, C., Tagliapietra, A., Tarca, L., Tessitore, F., Tomatis, F., Trione, A., Valagussa, F., and Invernizz, C.
Subjects: potenza, possibile, megarici, Parmenide, Severino, Aristotele, possest, Cusano, potenza, possibile, Cusano, Severino, Parmenide, megarici, Aristotele, possest
Published: 2017

39. Functional connectivity networks in asymptomatic and symptomatic DYT1 carriers

Author: Premi, E, Diano, Matteo, Gazzina, S, Cauda, Franco, Gualeni, V, Tinazzi, M, Fiorio, M, Liberini, P, Lazzarini, C, Archetti, S, Biasiotto, G, Turla, M, Bertasi, V, Cotelli, M, Gasparotti, R, Padovani, A, and Borroni, B.
Subjects: Adult, Cerebral Cortex, Male, Heterozygote, resting-state functional connectivity, Dystonia Musculorum Deformans, DYT1, Middle Aged, Magnetic Resonance Imaging, Connectome, Humans, Female, dystonia, dual regression, Molecular Chaperones
Abstract: DYT1 mutation is characterized by focal to generalized dystonia and incomplete penetrance. To explore the complex perturbations in the different neural networks and the mutual interactions among them, we studied symptomatic and asymptomatic DTY1 mutation carriers by resting-state functional MRI.A total of 7 symptomatic DYT1, 10 asymptomatic DYT1, and 26 healthy controls were considered. Resting-state functional MRI (Oxford Centre for Functional MRI of the Brain) [FMRIB] Software Library) (FSL) MELODIC, dual regression, (as a toolbox of FSL, with Nets is referred to "networks") (FSLNets) (http://fsl.fmrib.ox.ac.uk/fsl/fslwiki/FSLNets) was performed on 9 resting-state neural networks.DYT1 mutation signature (symptomatic DYT1 and asymptomatic DYT1) was characterized by increased connectivity in the dorsal attention network and in the left fronto-parietal network. Functional correlates of symptomatic DYT1 patients (symptomatic DYT1 vs healthy controls) showed increased connectivity in the sensorimotor network.This study argues that DYT1 dystonia is a network disorder, with crucial nodes in sensory-motor integration of posterior parietal structures. A better characterization of cortical networks involved in dystonia is crucial for possible neurophysiological therapeutic interventions. © 2016 International Parkinson and Movement Disorder Society.
Published: 2016

40. From Parkinson's disease to dementing alpha-synucleinopathies: subcortical 'matter'

Author: Gazzina, S., Premi, E., Turrone, R., Acosta-Cabronero, Julio, Alberici, A., Rizzetti, C., Gasparotti, R., Padovani, A., and Borroni, B.
Subjects: ddc:610
Abstract: Introduction: α-synucleinopathies, such as Parkinson’s Disease (PD) and Dementia with Lewy Bodies(DLB), are characterized by an ascending accumulation of α-synuclein extending from brainstem structures to the neocortex. Clinically, PD andDLB are clearly distinguished, while discriminationbetween Parkinson dementia (PDD) and DLB canbe subtle and actually based on temporal relationship between motor and cognitive symptoms. Studyof subcortical structures with MRI techniques couldprovide in-vivo information on the spread of pathology among these different clinical conditions.Objectives: To explore the patterns of atrophy atthe subcortical level in PD, PDD and DLB. In particular, we were interested in the markers of evolution from PD to PDD a
Published: 2016

41. Is aceruloplasminemia treatable? Combining iron chelation and fresh-frozen plasma treatment

Author: Poli, L., primary, Alberici, A., additional, Buzzi, P., additional, Marchina, E., additional, Lanari, A., additional, Arosio, C., additional, Ciccone, A., additional, Semeraro, F., additional, Gasparotti, R., additional, Padovani, A., additional, and Borroni, Barbara, additional
Published: 2016
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42. Erratum to: The Italian Registry of Endovascular Treatment in Acute Stroke: rationale, design and baseline features of patients (Neurol Sci (2015), 36, (985-993), 10.1007/s10072-014-2053-5)

Author: Mangiafico, S., Pracucci, G., Saia, V., Nencini, P., Inzitari, D., Nappini, S., Vallone, S., Zini, A., Fuschi, M., Cerone, D., Bergui, M., Cerrato, P., Gandini, R., Sallustio, F., Saletti, A., De Vito, A., Romano, D. G., Tassi, R., Causin, F., Baracchini, C., Piano, M., Motto, C., Ciccone, A., Gasparotti, R., Magoni, M., Giorgianni, A., Delodovici, M., Cavasin, N., Critelli, A., Gallucci, M., Carolei, A., Meloni, T., Corso, G., Vaudano, G., Duc, E., Zappoli, F., Cavallini, A., Padolecchia, R., Tassinari, T., Longoni, M., Salmaggi, A., Zampieri, P. G., Bovi, P., Puglioli, M., Chiti, A., Guidetti, G., Simonetti, L., Procaccianti, G., Menozzi, R., Scoditti, U., Ricciardi, F., Pezzella, F. R., Guarnieri, G., Andreone, V., and Toni, D.
Published: 2015

43. Pontine Tegmental Cap Dysplasia: developmental and cognitive outcome in three adolescent patients

Author: Briguglio, Marilena, Pinelli, L., Giordano, L., Ferraris, A., Germano', Eva, Micheletti, S., Severino, M. S., Bernardini, L., Loddo, S., Tortorella, Gaetano, Ormitti, F., Gasparotti, R., Borgatti, R., Romaniello, R., Arrigoni, F., Accorsi, P., Galil, J, Biancheri, R., Mirabelli, M., D’Amico, A., Del Giudice, E., Amorini, M., Briuglia, Silvana, Gallizzi, Romina, Gagliano, Antonella, La Torre, A., SALPIETRO DAMIANO, Carmelo, Chiapparini, L., D’Arrigo, S., Pantaleoni, C., Fiocchi, I., Triulzi, F., Pichiecchio, A., Signorini, S., Battini, R., Casarano, M., Di Sabato, M. L., Leuzzi, V., Bertini, E., Colafati, S., Zanni, G., Fazzi, E., Mercuri, E., Vitiello, G., Romani, M., Micalizzi, A., Simonati, A., Rossi, A., Valente, E. M., Briguglio, M, Pinelli, L, Giordano, L, Ferraris, A, Germanò, E, Micheletti, S, Severino, M, Bernardini, L, Loddo, S, Tortorella, G, Ormitti, F, Gasparotti, R, Rossi, A, Valente, Em, CBCD Study, Group, and DEL GIUDICE, Ennio
Subjects: Decussation, Male, Pediatrics, medicine.medical_specialty, Adolescent, Diffusion Tensor Tractography, lcsh:Medicine, Case Report, Nervous System Malformations, Adolescent age, spectrum, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Rare Diseases, children, Swallowing, pontine tegmental cap dysplasia, magnetic resonance imaging, medicine, Pedunculopontine Tegmental Nucleus, Humans, Genetics(clinical), PTCD, Pharmacology (medical), Neuropsychological assessment, disorders, Genetics (clinical), Cognitive deficit, Medicine(all), Pontine Tegmental Cap Dysplasia, brainstem malformation, cerebellar malformation, medicine.diagnostic_test, business.industry, lcsh:R, Cognition, General Medicine, Diffusion Tensor Imaging, Malformations, hindbrain, Pontine tegmental cap dysplasia, Female, Brainstem, medicine.symptom, business, 030217 neurology & neurosurgery, Tractography
Abstract: Pontine Tegmental Cap Dysplasia (PTCD) is a recently described, rare disorder characterized by a peculiar cerebellar and brainstem malformation. Nineteen patients have been reported to date, of which only one in the adolescent age, and data on the clinical, cognitive and behavioural outcome of this syndrome are scarce. Here we describe three adolescent patients with PTCD. All presented bilateral deafness and multiple cranial neuropathies, variably associated with skeletal, cardiac and gastro-intestinal malformations. Feeding and swallowing difficulties, that are often causative of recurrent aspiration pneumonias and death in the first years of life, completely resolved with age in all three patients. Neuropsychological assessment showed borderline to moderate cognitive impairment, with delay in adaptive functioning, visual-spatial and language deficits. Two of three patients also showed mild behavioural problems, although their overall socialization abilities were well preserved. Cochlear implantation in two patients significantly improved their relational and learning abilities. Fibre tractography confirmed the abnormal bundle of transversely oriented fibres forming the typical pontine "tegmental cap" and absence of decussation of the superior cerebellar peduncles, supporting the hypothesis that PTCD results from abnormal axonal guidance and/or migration. These data indicate that PTCD may have a favourable long-term outcome, with borderline cognitive deficit or even normal cognition and partially preserved speech.
Published: 2011

44. Relationships between Cerebral Small Resistance Artery Structure and Cerebral Blood Flow in Normotensive Subjects and in Hypertensive Patients RID E-9967-2010

Author: Boari GE, Gasparotti R, Porteri E, Mardighian D, De Ciuceis C, Cornali C, Cenzato M, Rizzoni D, Rosei EA, MORTINI , PIETRO, Boari, Ge, Gasparotti, R, Porteri, E, Mardighian, D, De Ciuceis, C, Cornali, C, Mortini, Pietro, Cenzato, M, Rizzoni, D, and Rosei, Ea
Published: 2010

45. CEREBRAL SMALL RESISTANCE ARTERY STRUCTURE AND CEREBRAL BLOOD FLOW IN NORMOTENSIVE SUBJECTS AND IN HYPERTENSIVE PATIENTS RID E-9967-2010

Author: Boari GEM, Gasparotti R, Porteri E, Mardighian D, De Ciuceis C, Cornali C, Cenzato M, Rizzoni D, Rosei EA, MORTINI , PIETRO, Boari, Gem, Gasparotti, R, Porteri, E, Mardighian, D, De Ciuceis, C, Cornali, C, Mortini, Pietro, Cenzato, M, Rizzoni, D, and Rosei, Ea
Published: 2010

46. A multimodal imaging study of never-medicated adults with schizofrenia

Author: Filippi, M, Canu, E, Agosta, F, Valsecchi, P, Pagani, E, Comi, G, Sacchetti, E, Gasparotti, R, Filippi, M, Canu, E, Agosta, F, Valsecchi, P, Pagani, E, Comi, G, Sacchetti, E, and Gasparotti, R
Published: 2010

47. Nei luoghi del design

Author: Petranzan,A, Pisaniello,S, Purini,F, Thermes, L, Accasto, G, DiPetta, R, Diso, R, Oddo, M, Secchi, B, Borsotti, M, Cattapan, F, Marzot, Nicola, Menegatti, F, Peticca ,M, Taormina , F, Tronchin, Walter, Peressa, A, Lazzarini, F, Rizzat, U, Donø, M, Gasparotti, R, De Batte, B, Cannata, M, Clementi , A, Masotti, G, Ricciuti, V, berrlingeri, F, Valle,P, Siola , U, Marzo, M, Cassani, G, Monstiroli, A, Di Bello P, Berti, A, Valesio, P, COTTONE, Anna, Petranzan,A, Pisaniello,S, Purini,F, Thermes, L, Accasto, G, DiPetta, R, Diso, R, Oddo, M, Secchi, B, Borsotti, M, Cattapan, F, Marzot, Nicola, Menegatti, F, Peticca ,M, Taormina , F, Tronchin, Walter, Peressa, A, Lazzarini, F, Rizzat, U, Donø, M, Gasparotti, R, De Batte, B, Cannata, M, Clementi , A, Masotti, G, Ricciuti, V, berrlingeri, F, Valle,P, Siola , U, Marzo, M, Cassani, G, Monstiroli, A, Di Bello P, Berti, A, Valesio, P, and Cottone, A.
Subjects: luoghi, design, Settore ICAR/13 - Disegno Industriale
Published: 2008

48. Diffusion tensor imaging and voxel-based morphometry study in early progressive supranuclear palsy

Author: Padovani, A, Borroni, B, Brambati, Sm, Agosti, C, Broli, M, Alonso, R, Scifo, P, Bellelli, G, Alberici, A, Gasparotti, R, PERANI, DANIELA FELICITA L., Padovani, A, Borroni, B, Brambati, Sm, Agosti, C, Broli, M, Alonso, R, Scifo, P, Bellelli, G, Alberici, A, Gasparotti, R, and Perani, DANIELA FELICITA L.
Published: 2006

49. Unruptured Aneurysms Italian Study (UAIS) background and method

Author: Versari, P. b, Tartara, F. b, Scerrati, M. c, Caroselli, G. c, Pasquini, U. c, Ciappetta, P. d, Vailati, G. d, Occhiogrosso, M. d, Biroli, F. e, Bonaldi, G. e, Calbucci, F. f, Andreoli, A. f, Leopardi, M. f, Raff, L. f, Bollati, A. g, Gasparotti, R. g, Martellotto, N. h, Distefano, G. h, Pinna, G. i, Francaviglia, N. j, Ventura, F. k, Orazio, G. k, Cristaudo, C. k, Consoli, V. l, Nicoletti, G. l, Albanese, V. m, Ceccotti, C. n, Frattarelli, M. o, Servadei, F. o, Cremonini, A. M. o, Taborelli, A. p, Corriero, G. q, Galli, G. r, Morandini, A. r, Medina, M. s, Padovani, R. t, Farneti, M. t, Ghadirpour, R. t, DiLorenzo, N. u, Mennonna, P. v, Ammannati, F. v, Mangiafico, S. v, Celerini, M. v, Paoli, L. v, Andrioli, G. w, Zerbi, D. w, Spaziante, R. x, Pau, A. x, Stefani, F. x, Zona, G. L. x, Castellan, L. x, Cantore, G. y, Innocenzi, G. y, Galzio, R. z, Ricci, A. z, Montinaro, A. aa, Cantisani, P. aa, Arena, O. ab, Tonnarelli, G. P. ac, Gagliardi, R. ad, Benvenuti, L. ad, Tomasello, F. ae, Paterniti, S. ae, Trincia, G. af, Conti, C. af, Broggi, G. ag, Giombini, S. ag, Solero, C. L. ag, Marras, C. ag, Todaro, Ciceri, E. ag, Fornari, M. ah, DeSantis, A. ah, Cardia, Ortolina, Rodriguez, R. ai, Gaetani, P. ai, Collice, M. aj, D'Aliberti, G. aj, Talamonti, G. aaj, LaCamera, A. aj, Boccardi, E. aj, Villani, R. ak, Gaini, S. ak, Miserocchi, G. ak, Branca, V. ak, Giovanelli, M. al, Cenzato, Scotti, G. al, Merli, A. am, Piazza, P. am, Sganzerla, E. an, Profeta, G. ao, Daniele, B. ao, Monsignore, R. ao, Cioffi, F. ap, Rotondo, M. ap, Natale, DeDivitiis, E. aq, F. aq, Franco, A. ar, Apolito, R. ar, Delehaye, L. ar, Sossio, C. as, Bellotti, C. at, Car, P. G. at, Benvenuto, F. at, Scienza, R. au, Berlucchi, S. au, Pavesi, G. au, Fiore, D. au, LaSeta, F. av, Filizzolo, F. aw, Fiumara, E. aw, Tumbiolo, S. aw, Benericetti, E. ax, Sacchelli, A. ax, Arienta, C. ay, Zappoli, F. ay, Buoncristiani, P. az, Buonaguidi, R. ba, Bianchini, E. ba, Boccardo, M. bb, Valsania, V. bb, Bruzzone, L. bb, Cantini, L. R. bc, Marconi, F. bc, Parenti, G. F. bd, Liberti, G. bd, Severino, P. be, Delitala, A. bf, Cotroneo, E. bf, Gazzeri, G. bg, Fiume, D. bg, Esposito, S. bh, Agrillo, U. bi, Sidoti, C. bi, Maira, G. bj, Vignati, A. bj, Marchese, E. bj, Delfini, R. bk, Guidetti, G. bk, Bufatti, P. bl, Strabella, G. bm, D'Angelo, V. bn, Monte, Florio, F. bn, Olivieri, G. bo, Palma, L. bp, Serchi, E. bp, Fontana, R. bq, Resta, M. br, Faccani, G. bs, Musso, C. bs, Ducati, A. bt, Bradac, G. B. bt, Longatti, P. bu, Tacconi, L. bv, Skrap, M. bw, Nicassio, N. bw, Graziussi, G. bx, Migliaccio, N. bx, Puglisi, A. bx, Tomei, G. by, Bonfanti, N. by, Tabano, A. by, Bricolo, A. bz, Pasqualin, Beltramello, Colombo, F. ca, Causin, Perini, S. ca, MAIURI, FRANCESCO, BRIGANTI, FRANCESCO, Versari, P. b, Tartara, F. b, Scerrati, M. c, Caroselli, G. c, Pasquini, U. c, Ciappetta, P. d, Vailati, G. d, Occhiogrosso, M. d, Biroli, F. e, Bonaldi, G. e, Calbucci, F. f, Andreoli, A. f, Leopardi, M. f, Raff, L. f, Bollati, A. g, Gasparotti, R. g, Martellotto, N. h, Distefano, G. h, Pinna, G. i, Francaviglia, N. j, Ventura, F. k, Orazio, G. k, Cristaudo, C. k, Consoli, V. l, Nicoletti, G. l, Albanese, V. m, Ceccotti, C. n, Frattarelli, M. o, Servadei, F. o, Cremonini, A. M. o, Taborelli, A. p, Corriero, G. q, Galli, G. r, Morandini, A. r, Medina, M., Padovani, R. t, Farneti, M. t, Ghadirpour, R. t, Dilorenzo, N. u, Mennonna, P. v, Ammannati, F. v, Mangiafico, S. v, Celerini, M. v, Paoli, L. v, Andrioli, G. w, Zerbi, D. w, Spaziante, R. x, Pau, A. x, Stefani, F. x, Zona, G. L. x, Castellan, L. x, Cantore, G. y, Innocenzi, G. y, Galzio, R. z, Ricci, A. z, Montinaro, A., Aa, Cantisani, P., Aa, Arena, O., Ab, Tonnarelli, G. P., Ac, Gagliardi, R., Ad, Benvenuti, L., Ad, Tomasello, F., Ae, Paterniti, S., Ae, Trincia, G., Af, Conti, C., Af, Broggi, G., Ag, Giombini, S., Ag, Solero, C. L., Ag, Marras, C., Ag, Todaro, Ciceri, E., Ag, Fornari, M., Ah, Desantis, A., Ah, Cardia, Ortolina, Rodriguez, R., Ai, Gaetani, P., Ai, Collice, M., Aj, D'Aliberti, G., Aj, Talamonti, G., Aaj, Lacamera, A., Aj, Boccardi, E., Aj, Villani, R., Ak, Gaini, S., Ak, Miserocchi, G., Ak, Branca, V., Ak, Giovanelli, M., Al, Cenzato, Scotti, G., Al, Merli, A., Am, Piazza, P., Am, Sganzerla, E., An, Profeta, G., Ao, Daniele, B., Ao, Monsignore, R., Ao, Cioffi, F., Ap, Rotondo, M., Ap, Natale, Dedivitiis, E., Aq, Maiuri, Francesco, F., Aq, Briganti, Francesco, Franco, A., Ar, Apolito, R., Ar, Delehaye, L., Ar, Sossio, C., A, Bellotti, C., At, Car, P. G., At, Benvenuto, F., At, Scienza, R., Au, Berlucchi, S., Au, Pavesi, G., Au, Fiore, D., Au, Laseta, F., Av, Filizzolo, F., Aw, Fiumara, E., Aw, Tumbiolo, S., Aw, Benericetti, E., Ax, Sacchelli, A., Ax, Arienta, C., Ay, Zappoli, F., Ay, Buoncristiani, P., Az, Buonaguidi, R., Ba, Bianchini, E., Ba, Boccardo, M., Bb, Valsania, V., Bb, Bruzzone, L., Bb, Cantini, L. R., Bc, Marconi, F., Bc, Parenti, G. F., Bd, Liberti, G., Bd, Severino, P., Be, Delitala, A., Bf, Cotroneo, E., Bf, Gazzeri, G., Bg, Fiume, D., Bg, Esposito, S., Bh, Agrillo, U., Bi, Sidoti, C., Bi, Maira, G., Bj, Vignati, A., Bj, Marchese, E., Bj, Delfini, R., Bk, Guidetti, G., Bk, Bufatti, P., Bl, Strabella, G., Bm, D'Angelo, V., Bn, Monte, Florio, F., Bn, Olivieri, G., Bo, Palma, L., Bp, Serchi, E., Bp, Fontana, R., Bq, Resta, M., Br, Faccani, G., B, Musso, C., B, Ducati, A., Bt, Bradac, G. B., Bt, Longatti, P., Bu, Tacconi, L., Bv, Skrap, M., Bw, Nicassio, N., Bw, Graziussi, G., Bx, Migliaccio, N., Bx, Puglisi, A., Bx, Tomei, G., By, Bonfanti, N., By, Tabano, A., By, Bricolo, A., Bz, Pasqualin, Beltramello, Colombo, F., Ca, Causin, Perini, and S., Ca
Subjects: Aneurysm
Published: 2006

50. The importance of performing an accurate images preprocessing in MR diffusion analysis

Author: Pinardi, C., primary, Ambrosi, C., additional, Maddalo, M., additional, Dusi, F., additional, Duina, A., additional, Mascaro, L., additional, Gasparotti, R., additional, and Moretti, R., additional
Published: 2016
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