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173 results on '"Gaskin, K. J."'

2. The Role of Body Protein Studies in Clinical Trials

Author

Allen, B. J., Blagojevic, N., Delaney, I., Pollock, C. A., Ibels, L. S., Allman, M. A., Tiller, D. J., Gaskin, K. J., Baur, L. A., Waters, D. L., Cowell, C., Ambler, G., Quigley, C., Fletcher, J. P., Chu, Ernest H. Y., editor, Yasumura, Seiichi, editor, Harrison, Joan E., editor, McNeill, Kenneth G., editor, Woodhead, Avril D., editor, and Dilmanian, F. Avraham, editor

Published
1990
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3. Body Composition in Cystic Fibrosis

Author

Gaskin, K. J., Waters, D. L. M., Soutter, V. L., Baur, L., Allen, B. J., Blagojevic, N., Parsons, D., Chu, Ernest H. Y., editor, Yasumura, Seiichi, editor, Harrison, Joan E., editor, McNeill, Kenneth G., editor, Woodhead, Avril D., editor, and Dilmanian, F. Avraham, editor

Published
1990
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18. Mutation Analysis and Embryonic Expression of the HLXB9 Currarino Syndrome Gene

Author

Hagan, D. M., Ross, A. J., Strachan, T., Lynch, S. A., Ruiz-Perez, V., Wang, Y. M., Scambler, P., Custard, E., Reardon, W., Hassan, S., Muenke, M., Nixon, P., Papapetrou, C., Winter, R. M., Edwards, Y., Morrison, K., Barrow, M., Cordier-Alex, M. P., Correia, P., Galvin-Parton, P. A., Gaskill, S., Gaskin, K. J., Garcia-Minaur, S., Gereige, R., Hayward, R., Homfray, T., McKeown, C., Murday, V., Plauchu, H., Shannon, N., Spitz, L., and Lindsay, S.

Subjects
Human genetics -- Research, Homeobox genes -- Research, Heredity -- Analysis, Amino acids -- Research, Proteins -- Research, Gene mutations -- Research, Biological sciences
Published
2000

39. Age-Related Alterations of Immunoreactive Pancreatic Cationic Trypsinogen in Sera from Cystic Fibrosis Patients with and without Pancreatic Insufficiency

Author

Durie, P R, Forstner, G G, Gaskin, K J, Moore, D J, Cleghorn, G J, Wong, S S, and Corey, M L

Abstract

ABSTRACT: Serum immunoreactive cationic trypsinogen levels were determined in 99 control subjects and 381 cystic fibrosis (CF) patients. To evaluate the status of the exocrine pancreas all CF patients had previously undergone fecal fat balance studies and/or pancreatic stimulation tests. Three hundred fourteen CF patients had fat malabsorption and/or had inadequate pancreatic enzyme secretion (pancreatic insufficiency) requiring oral pancreatic enzyme supplements with meals. Sixty-seven CF patients did not have fat malabsorption and/or had adequate enzyme secretion (pancreatic sufficiency) and were not receiving pancreatic enzyme supplements with meals. Mean serum trypsinogen in 99 control subjects was 31.4 ± 14.8 µg/liter (± 2 SD) and levels did not vary with age or sex. In CF infants (< 2 yr) with pancreatic insufficiency, mean serum trypsinogen was significantly above the non-CF values (p<0.001). Ninety-one percent of the CF infants had elevated levels. Serum trypsinogen values in the pancreatic insufficient group declined steeply up to 5 years, reaching subnormal values by age 6. An equation was developed which described these age-related changes very accurately. Only six CF patients with pancreatic insufficiency had serum trypsinogen levels above the 95% confidence limits of this equation. In contrast, there was no age related decline in serum trypsinogen among the CF group with pancreatic sufficiency. Under 7 yr, serum trypsinogen failed to distinguish the two groups. In those over 7 yr of age, however, serum trypsinogen was significantly higher than the CF group with pancreatic insufficiency (p<0.001), and 93% had values within or above the control range. In conclusion, serum trypsinogen appears to be a useful screening test for CF in infancy. Between 2 and 7 yr of age this test is of little diagnostic value. After 7 yr of age, serum trypsinogen can reliably distinguish between CF patients with and without pancreatic insufficiency.

Published
1986
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44. OUTCOME OF SURGERY FOR BILIARY ATRESIA

Author

DORNEY, S. F. A., primary, MIDDLETON, A. W., additional, MARTIN, H. C. O., additional, CUMMINS, G., additional, SHUN, A., additional, Gaskin, K. J., additional, O'Loughlin, E. V., additional, and Kamath, K. R., additional

Published
1989
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49. Resting energy expenditure in female children with cystic fibrosis - effect of puberty.

Author

Allen, J. R., Barclay, A., Prior, R., Byler, E., Gruca, M. A., Van Asperen, P., Cooper, P., and Gaskin, K. J.

Subjects
*PUBERTY, *CALORIC expenditure, *CYSTIC fibrosis in children, *NUTRITION, *MENARCHE
Abstract

Background - The female gender has been shown to be one of the contributing factors to elevated resting energy expenditure (REE) in children with cystic fibrosis (CF), but it is not known if this effect is influenced by pubertal development. Objective - The aim of this study was to determine the effect of puberty on REE, in females with CF. Design - Children with CF were recruited from the CF clinic at the Children's Hospital at Westmead and controls were recruited through families and friends of hospital staff. All children were aged 5-18 years and were generally well. REE, anthropometry and self-reported pubertal staging were measured in 38 children with CF (27 pre-menarche, 11 post-menarche) and 63 controls (42 pre-menarche, 21 post-menarche) in an outpatient setting. The post-menarche group were all measured in the follicular stage of their menstrual cycle. Outcomes - Females with CF had a higher REE than controls (108.4 ± 11.1% of predicted from controls P<0.001). However this increase in REE was only significant for pre-menarche females (109.7 ± 12.1% of predicted from controls, P<0.005) compared with a median 104.0% (92.1, 116.6%) of predicted from control data (P=0.06) for post-menarche females. There was no significant difference in REE (% predicted from controls) between pre- and post-menarche children with CF (P=0.12). Conclusions - Pre-menarche females with CF had raised REE in contrast with post-menarche females but this finding must be confirmed with further numbers of post-menarche females. This study implies that young females with CF may need more intensive dietary management, due to raised REE, in order to maintain growth, nutritional status and possibly improve survival. [ABSTRACT FROM AUTHOR]

Published
2004

50. NMR measurements of the diffusional permeability of water in cultured colonic epithelial cancer cells.

Author

Nouri-Sorkhabi MH, Chapman BE, O'Loughlin EV, Li Z, Kuchel PW, and Gaskin KJ

Subjects
4-Chloromercuribenzenesulfonate pharmacology, Biological Transport drug effects, Cation Transport Proteins genetics, Cell Line, Tumor, Diffusion drug effects, Dithiothreitol pharmacology, Epithelial Cells drug effects, Glyburide pharmacology, Humans, Iron-Binding Proteins genetics, Magnetic Resonance Spectroscopy, Time Factors, Cell Membrane Permeability, Colonic Neoplasms pathology, Epithelial Cells metabolism, Epithelial Cells pathology, Water metabolism
Abstract

The water residence time and diffusional water permeability in colonic epithelial T84 cancer cells was measured using (1)H NMR spectroscopy; the values estimated were 35.2+/-2.8 ms and (7.4+/-0.6)x10(-3)cms(-1), respectively. Water permeability was inhibited to approximately 10% of its original value by the mercurial diuretic, p-chloromercuribenzenesulfonate (PCMBS; 1mM), and fully restored by dithiothreitol (DTT; 1mM). The permeability was also inhibited reversibly to approximately 55%, by extracellular glibenclamide (1mM), an inhibitor of some ATP-binding cassette (ABC) transporters, including the cystic fibrosis transmembrane conductance regulator (CFTR). Addition of the phosphodiesterase inhibitor, 3-isobutyl-1-methylxanthine (IMBX; 0.1-1mM) and the adenylate cyclase activator, forskolin (0.1-1mM) did not alter water permeability. It is concluded that in T84 cells water diffuses through the membrane lipid bilayer and via channels that are inhibited by PCMBS, including the channels that are known to be inhibited by glibenclamide.

Published
2005
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