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467 results on '"Gascon, Joaquim"'

1. Evaluation and validation of a PrintrLab-based LAMP assay to identify Trypanosoma cruzi in newborns in Bolivia: a proof-of-concept study

Author

Rojas Panozo, Lizeth, Rivera Nina, Silvia, Wehrendt, Diana P, Casellas, Aina, Pinto, Lilian, Mendez, Susana, Kuo, Chi-Wei, Lozano, Daniel F, Ortiz, Lourdes, Pinazo, Maria-Jesus, Picado, Albert, Sanz, Sergi, Abril, Marcelo, Gascon, Joaquim, Wong, Season, Schijman, Alejandro G, Torrico, Faustino, and Alonso-Padilla, Julio

Published
2024
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3. Efficacy and safety of fexinidazole for treatment of chronic indeterminate Chagas disease (FEXI-12): a multicentre, randomised, double-blind, phase 2 trial

Author

Pinazo, Maria-Jesus, Forsyth, Colin, Losada, Irene, Esteban, Elena Trigo, García-Rodríguez, Magdalena, Villegas, Maria Luz, Molina, Israel, Crespillo-Andújar, Clara, Gállego, Montserrat, Ballart, Cristina, Ramirez, Juan Carlos, Aden, Tilman, Hoerauf, Achim, Pfarr, Kenneth, Vaillant, Michel, Marques, Tayná, Fernandes, Jayme, Blum, Bethania, Ribeiro, Isabela, Sosa-Estani, Sergio, Barreira, Fabiana, and Gascón, Joaquim

Published
2024
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7. New regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease (BENDITA): a phase 2, double-blind, randomised trial

Author

Arteaga, Roger, de la Barra, Anabelle, Camacho Borja, Jhonny, Martinez, Ivana, Fernandes, Jayme, Garcia, Lineth, Lozano, Daniel, Palacios, Alejandro, Schijman, Alejandro, Pinazo, Maria Jesus, Pinto, Jimmy, Rojas, Gimena, Estevao, Igor, Ortega-Rodriguez, Uriel, Mendes, Maria Tays, Schuck, Edgar, Hata, Katsura, Maki, Noritsugu, Asada, Makoto, Torrico, Faustino, Gascón, Joaquim, Barreira, Fabiana, Blum, Bethania, Almeida, Igor C, Alonso-Vega, Cristina, Barboza, Tayná, Bilbe, Graeme, Correia, Erika, Garcia, Wilson, Ortiz, Lourdes, Parrado, Rudy, Ramirez, Juan Carlos, Ribeiro, Isabela, Strub-Wourgaft, Nathalie, Vaillant, Michel, and Sosa-Estani, Sergio

Published
2021
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8. Chagas Disease in Europe

Author

Alonso-Padilla, Julio, Pinazo, María Jesús, Gascón, Joaquim, Kaufmann, Stefan H.E., Section Editor, Weber, Olaf, Series Editor, Altcheh, Jaime Marcelo, editor, and Freilij, Hector, editor

Published
2019
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11. Plasma-Derived Extracellular Vesicles as Potential Biomarkers in Heart Transplant Patient with Chronic Chagas Disease

Author

Cortes-Serra, Nuria, Mendes, Maria Tays, Mazagatos, Clara, Segui-Barber, Joan, Ellis, Cameron C., Ballart, Cristina, Garcia-Alvarez, Ana, Gallego, Montserrat, Gascon, Joaquim, Almeida, Igor C., Pinazo, Maria Jesus, and Fernandez-Becerra, Carmen

Subjects
Posaconazole -- Health aspects, Heart transplantation -- Health aspects, Parasitic diseases -- Health aspects, Epidemiology -- Health aspects, Cardiac patients -- Health aspects, Chagas disease -- Health aspects, Biological markers -- Health aspects, Health
Abstract

Chagas disease, caused by Trypanosoma cruzi parasite, is one of the most prevalent parasitic infections in Latin America and is responsible for millions of clinical cases. However, mainly because of [...]

Published
2020
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12. Probing for Trypanosoma cruzi Cell Surface Glycobiomarkers for the Diagnosis and Follow-Up of Chemotherapy of Chagas Disease

Author

Schocker, Nathaniel S., Portillo, Susana, Ashmus, Roger A., Brito, Carlos R. N., Silva, Igor E., Mendoza, Yanira Cordero, Marques, Alexandre F., Monroy, Erika Y., Pardo, Andrew, Izquierdo, Luis, Gállego, Montserrat, Gascon, Joaquim, Almeida, Igor C., Michael, Katja, Witczak, Zbigniew J., editor, and Bielski, Roman, editor

Published
2018
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14. Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial

Author

Santina, Glaucia, Blum, Bethania, Correia, Erika, Garcia-Bournisen, Facundo, Vaillant, Michel, Morales, Jimena Ramos, Pinto Rocha, Jimy Jose, Rojas Delgadillo, Gimena, Magne Anzoleaga, Helmut Ramon, Mendoza, Nilce, Quechover, Roxana Challapa, Caballero, Maria Yurly Escobar, Lozano Beltran, Daniel Franz, Zalabar, Albert Mendoza, Rojas Panozo, Lizeth, Palacios Lopez, Alejandro, Torrico Terceros, Dunia, Fernandez Galvez, Violeta Alejandra, Cardozo, Letty, Cuellar, Gabriela, Vasco Arenas, Rudy Nelson, Gonzales, Isabel, Hoyos Delfin, Carlos Florencio, Garcia, Lineth, Parrado, Rudy, de la Barra, Anabelle, Montano, Nair, Villarroel, Sandro, Duffy, Tomas, Bisio, Margarita, Ramirez, Juan Carlos, Duncanson, Fred, Everson, Michael, Daniels, Antonia, Asada, Makoto, Cox, Eugene, Wesche, David, Diderichsen, Paul Matthias, Marques, Alexandre F, Izquierdo, Luis, Sender, Silvia Sanz, Reverter, Joan Carlos, Morales, Manuel, Jimenez, Wladimiro, Torrico, Faustino, Gascon, Joaquim, Ortiz, Lourdes, Alonso-Vega, Cristina, Pinazo, María-Jesús, Schijman, Alejandro, Almeida, Igor C, Alves, Fabiana, Strub-Wourgaft, Nathalie, and Ribeiro, Isabela

Published
2018
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17. Identification of Trypanosoma cruzi Discrete Typing Units (DTUs) in Latin-American migrants in Barcelona (Spain)

Author

Abras, Alba, Gállego, Montserrat, Muñoz, Carmen, Juiz, Natalia A, Ramírez, Juan Carlos, Cura, Carolina I, Tebar, Silvia, Fernández-Arévalo, Anna, Pinazo, María-Jesús, de la Torre, Leonardo, Posada, Elizabeth, Navarro, Ferran, Espinal, Paula, Ballart, Cristina, Portús, Montserrat, Gascón, Joaquim, and Schijman, Alejandro G

Published
2017
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20. Purification of Glycosylphosphatidylinositol-Anchored Mucins from Trypanosoma cruzi Trypomastigotes and Synthesis of α-Gal-Containing Neoglycoproteins: Application as Biomarkers for Reliable Diagnosis and Early Assessment of Chemotherapeutic Outcomes of Chagas Disease

Author

Ortega-Rodriguez, Uriel, primary, Portillo, Susana, additional, Ashmus, Roger A., additional, Duran, Jerry A., additional, Schocker, Nathaniel S., additional, Iniguez, Eva, additional, Montoya, Alba L., additional, Zepeda, Brenda G., additional, Olivas, Janet J., additional, Karimi, Nasim H., additional, Alonso-Padilla, Julio, additional, Izquierdo, Luis, additional, Pinazo, Maria-Jesús, additional, de Noya, Belkisyolé Alarcón, additional, Noya, Oscar, additional, Maldonado, Rosa A., additional, Torrico, Faustino, additional, Gascon, Joaquim, additional, Michael, Katja, additional, and Almeida, Igor C., additional

Published
2019
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22. State-of-the-Art in the Drug Discovery Pathway for Chagas Disease: A Framework for Drug Development and Target Validation

Author

Gabaldón-Figueira,Juan Carlos, Martinez-Peinado,Nieves, Escabia,Elisa, Ros-Lucas,Albert, Chatelain,Eric, Scandale,Ivan, Gascon,Joaquim, Pinazo,María-Jesús, and Alonso-Padilla,Julio

Subjects
Research and Reports in Tropical Medicine
Abstract

Juan Carlos Gabaldón-Figueira,1 Nieves Martinez-Peinado,1 Elisa Escabia,1 Albert Ros-Lucas,1,2 Eric Chatelain,3 Ivan Scandale,3 Joaquim Gascon,1,2 María-Jesús Pinazo,2,3 Julio Alonso-Padilla1,2 1Barcelona Institute for Global Health (ISGlobal), Hospital Clínic—University of Barcelona, Barcelona, Spain; 2CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III (CIBERINFEC, ISCIII), Madrid, Spain; 3Drugs for Neglected Diseases Initiative (DNDi), Geneva, SwitzerlandCorrespondence: Julio Alonso-Padilla, Barcelona Institute for Global Health (ISGlobal), Hospital Clínic—University of Barcelona. Carrer Rosselló 149, Barcelona, 08036, Spain, Tel +34 932275400 – ext. 4284, Email julio.a.padilla@isglobal.orgAbstract: Chagas disease is the most important protozoan infection in the Americas, and constitutes a significant public health concern throughout the world. Development of new medications against its etiologic agent, Trypanosoma cruzi, has been traditionally slow and difficult, lagging in comparison with diseases caused by other kinetoplastid parasites. Among the factors that explain this are the incompletely understood mechanisms of pathogenesis of T. cruzi infection and its complex set of interactions with the host in the chronic stage of the disease. These demand the performance of a variety of in vitro and in vivo assays as part of any drug development effort. In this review, we discuss recent breakthroughs in the understanding of the parasite’s life cycle and their implications in the search for new chemotherapeutics. For this, we present a framework to guide drug discovery efforts against Chagas disease, considering state-of-the-art preclinical models and recently developed tools for the identification and validation of molecular targets.Keywords: Chagas disease, Trypanosoma cruzi, drug development, screenings, target, animal models

Published
2023

24. Intravenous Artesunate Reduces Parasite Clearance Time, Duration of Intensive Care, and Hospital Treatment in Patients With Severe Malaria in Europe: The TropNet Severe Malaria Study

Author

TropNet Severe Malaria Investigator Group, Kurth, Florian, Develoux, Michel, Mechain, Matthieu, Clerinx, Jan, Antinori, Spinello, Gjørup, Ida E., Gascon, Joaquím, Mørch, Kristine, Nicastri, Emanuele, Ramharter, Michael, Bartoloni, Alessandro, Visser, Leo, Rolling, Thierry, Zanger, Philipp, Calleri, Guido, Salas-Coronas, Joaquín, Nielsen, Henrik, Just-Nübling, Gudrun, Neumayr, Andreas, Hachfeld, Anna, Schmid, Matthias L., Antonini, Pietro, Pongratz, Peter, Kern, Peter, da Cunha, José Saraiva, Soriano-Arandes, Antoni, Schunk, Mirjam, Suttorp, Norbert, Hatz, Christoph, and Zoller, Thomas

Published
2015

26. Development and Application of an Assay to Evaluate the Anti-Parasitic Effect of Humoral Responses against Trypanosoma cruzi

Author

Martinez-Peinado, Nieves, primary, Gabaldon-Figueira, Juan Carlos, additional, Martinez-Añon, Ignacio, additional, Rodríguez-Gordo, Cristian, additional, Robleda-Castillo, Raquel, additional, Pinazo, Maria-Jesus, additional, Bigey, Pascal, additional, Gascon, Joaquim, additional, and Alonso-Padilla, Julio, additional

Published
2023
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27. Identification of compounds with activity against Trypanosoma cruzi within a collection of synthetic nucleoside analogs

Author

Barnadas-Carceller, Berta, primary, Martinez-Peinado, Nieves, additional, Gómez, Laura Córdoba, additional, Ros-Lucas, Albert, additional, Gabaldón-Figueira, Juan Carlos, additional, Diaz-Mochon, Juan J., additional, Gascon, Joaquim, additional, Molina, Ignacio J., additional, Pineda de las Infantas y Villatoro, María José, additional, and Alonso-Padilla, Julio, additional

Published
2023
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28. Correction: Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the “Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions”

Author

Shikanai-Yasuda, Maria Aparecida, primary, Mediano, Mauro Felippe Felix, additional, Novaes, Christina Terra Gallafrio, additional, Sousa, Andréa Silvestre de, additional, Sartori, Ana Marli Christovam, additional, Santana, Rodrigo Carvalho, additional, Correia, Dalmo, additional, Castro, Cleudson Nery de, additional, Severo, Marilia Maria dos Santos, additional, Hasslocher-Moreno, Alejandro Marcel, additional, Fernandez, Marisa Liliana, additional, Salvador, Fernando, additional, Pinazo, Maria Jesús, additional, Bolella, Valdes Roberto, additional, Furtado, Pedro Carvalho, additional, Corti, Marcelo, additional, Pinto, Ana Yecê Neves, additional, Fica, Alberto, additional, Molina, Israel, additional, Gascon, Joaquim, additional, Viñas, Pedro Albajar, additional, Cortez-Escalante, Juan, additional, Jr, Alberto Novaes Ramos, additional, and Almeida, Eros Antonio de, additional

Published
2023
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29. Probing for Trypanosoma cruzi Cell Surface Glycobiomarkers for the Diagnosis and Follow-Up of Chemotherapy of Chagas Disease

Author

Schocker, Nathaniel S., primary, Portillo, Susana, additional, Ashmus, Roger A., additional, Brito, Carlos R. N., additional, Silva, Igor E., additional, Mendoza, Yanira Cordero, additional, Marques, Alexandre F., additional, Monroy, Erika Y., additional, Pardo, Andrew, additional, Izquierdo, Luis, additional, Gállego, Montserrat, additional, Gascon, Joaquim, additional, Almeida, Igor C., additional, and Michael, Katja, additional

Published
2017
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30. A Branched and Double Alpha-Gal-Bearing Synthetic Neoglycoprotein as a Biomarker for Chagas Disease

Author

Montoya, Alba L., primary, Carvajal, Elisa G., additional, Ortega-Rodriguez, Uriel, additional, Estevao, Igor L., additional, Ashmus, Roger A., additional, Jankuru, Sohan R., additional, Portillo, Susana, additional, Ellis, Cameron C., additional, Knight, Colin D., additional, Alonso-Padilla, Julio, additional, Izquierdo, Luis, additional, Pinazo, Maria-Jesus, additional, Gascon, Joaquim, additional, Suarez, Veronica, additional, Watts, Douglas M., additional, Malo, Iliana R., additional, Ramsey, Janine M., additional, Alarcón De Noya, Belkisyolé, additional, Noya, Oscar, additional, Almeida, Igor C., additional, and Michael, Katja, additional

Published
2022
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32. Blood and Tissue Protozoa

Author

Pinazo, María-Jesús, primary, Aldasoro, Edelweiss, additional, Calvo-Cano, Antonia, additional, Picado, Albert, additional, Muñoz, Jose, additional, and Gascon, Joaquim, additional

Published
2017
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33. List of Contributors

Author

Abrahamian, Fredrick M., primary, Aldape, Michael J., additional, Aldasoro, Edelweiss, additional, Allen, Upton D., additional, Al-Sum, Hythem, additional, Anadkat, Milan J., additional, Anders, Katherine, additional, Angelakis, Emmanouil, additional, Angus, Brian John, additional, Antoniadou, Anastasia, additional, Arena, Fabio, additional, Arends, Joop E., additional, Arribas, Jose R., additional, Artenstein, Andrew W., additional, Atherton, John C., additional, Aucott, John N., additional, Aw, Tar-Ching, additional, Babcock, Hilary M., additional, Bailey, Robin, additional, Bailey, Thomas C., additional, Banks, Adam Z., additional, Barillo, David J., additional, Barrette, Ernie-Paul, additional, Bauer, Martijn P., additional, Bayston, Roger, additional, Beard, C. Ben, additional, Beardsley, Justin, additional, Beeching, Nick J., additional, Bégué, Rodolfo E., additional, Beldi, Guido, additional, Benson, Constance A., additional, Berbari, Elie F., additional, Berenger, Jean-Michel, additional, Berger, Christoph, additional, Bernardino, Jose I., additional, Bille, Jacques, additional, Billioux, Alexander C., additional, Bitnun, Ari, additional, Blair, Iain, additional, Blanche, Stéphane, additional, Bleck, Thomas P., additional, Bleeker-Rovers, Chantal P., additional, Bleijenberg, Gijs, additional, Bloch, Karen C., additional, Blum, Johannes, additional, Blumberg, Emily A., additional, Bonomo, Robert A., additional, Bonten, Marc J.M., additional, Bourayou, Rafik, additional, Bouza, Emilio, additional, Brandt, K. Ashley, additional, Bretelle, Florence, additional, Brisse, Sylvain, additional, Britton, Warwick J., additional, Brook, Itzhak, additional, Brouwer, Matthijs C., additional, Browne, Sarah K., additional, Bryant, Amy E., additional, Bühler, Silja, additional, Bulger, Eileen M., additional, Buller, R. Mark L., additional, Burke, Leah A., additional, Burri, Christian, additional, Butler, Marcus W., additional, Calandra, Thierry, additional, Calfee, David P., additional, Calvo-Cano, Antonia, additional, Cameron, D. William, additional, Carcillo, Joseph A., additional, Carson, Gail, additional, Chambers, Stephen T., additional, Charrel, Remi N., additional, Nguyen, Vinh Chau Van, additional, Chevaliez, Stéphane, additional, Chiller, Tom M., additional, Christaki, Eirini, additional, Chung, Kevin K., additional, Clifford, David B., additional, Clumeck, Nathan, additional, Cohen, Jonathan, additional, Collinge, John, additional, Conlon, Christopher P., additional, Conrad, Curdin, additional, Cooke, Fiona J., additional, Cope, Jennifer Rittenhouse, additional, Corey, G. Ralph, additional, Cross, John H., additional, Cunha, Burke A., additional, Cunha, Cheston B., additional, D'Journo, Benoit, additional, Daikos, George L., additional, Daniels, Johannes M.A., additional, Davidson, Robert N., additional, Day, Nicholas P.J., additional, De Cock, Kevin M., additional, de Silva, Thushan I., additional, de Vries, Henry J.C., additional, de Wit, Stéphane, additional, Delaloye, Julie, additional, Denning, David W., additional, Dennis, David T., additional, Dhanireddy, Shireesha, additional, Dielubanza, Elodi J., additional, Diemert, David J., additional, Doganay, Mehmet, additional, Doherty, Tom, additional, Dolecek, Christiane, additional, Dondorp, Arjen M., additional, Douglas, Abby, additional, Drancourt, Michel, additional, Dubourg, Grégory, additional, Dudley, Michael N., additional, Durand, Guillaume, additional, Eckhardt, Benjamin J., additional, Efstratiou, Androulla, additional, Ekkelenkamp, Miquel B., additional, Eranki, Ambika, additional, Erdem, Hakan, additional, Escota, Gerome V., additional, Evans, Heather L., additional, Eziefula, Alice Chijioke, additional, Fenollar, Florence, additional, Fenwick, Alan, additional, Fierer, Joshua, additional, Finch, Roger G., additional, Fleckenstein, James M., additional, Forstner, Christina, additional, Foschi, Federico, additional, Fournier, Pierre-Edouard, additional, French, Martyn A., additional, Gage, Kenneth L., additional, Garcia, Lynne S., additional, Gascon, Joaquim, additional, Gastañaduy, Arturo S., additional, Gautret, Philippe, additional, Geisler, William M., additional, Ghanem, Khalil G., additional, Giani, Tommaso, additional, Giannella, Maddalena, additional, Gilliam, Bruce L., additional, Gilliet, Michel, additional, Glaser, Carol A., additional, Glupczynski, Youri, additional, Gnann, John W., additional, Goldstein, Ellie J.C., additional, Gottstein, Bruno, additional, Gouriet, Frederique, additional, Gravitt, Patti E., additional, Green, Michael D., additional, Green, Stephen T., additional, Groll, Andreas H., additional, Gulick, Roy M., additional, Gupta, Arjun, additional, Habib, Gilbert, additional, Harbarth, Stephan, additional, Harris, Marianne, additional, Hayden, Frederick G., additional, Hetem, David J., additional, Hill, Philip C., additional, Hirschel, Bernard, additional, Hodowanec, Aimee C., additional, Hoffart, Louis, additional, Hoffmann, Christian, additional, Holland, Steven M., additional, Horby, Peter W., additional, Horne, David J., additional, Hraiech, Sami, additional, Hull, Mark W., additional, Huttner, Angela, additional, Ingram, Richard J.M., additional, Islam, Jasmin, additional, Ison, Michael G., additional, James, Scott H., additional, Jenkins, Claire, additional, Jenkins, Stephen G., additional, Jensen, Jørgen Skov, additional, Johnston, Christine, additional, Jones, Theodore B., additional, Jordan, Stephen J., additional, Julian, Kathleen G., additional, Kato, Yasuyuki, additional, Kauffman, Carol A., additional, Kaye, Keith S., additional, Keane, Michael P., additional, Keeney, James, additional, Kelly, Paul, additional, Kent, Stephen J., additional, Kern, Winfried V., additional, Keynan, Yoav, additional, Kim, Andrea A., additional, Koné-Paut, Isabelle, additional, Kosmidis, Chris, additional, Kroes, Aloys C.M., additional, Kroon, Frank P., additional, Ksiazek, Thomas G., additional, Kuhlmann, F. Matthew, additional, Kuijper, Ed J., additional, Kwon, Jennie H., additional, Kyei, George B., additional, Lacombe, Karine, additional, Lagacé-Wiens, Philippe, additional, Lagier, Jean-Christophe, additional, Lamagni, Theresa, additional, Landraud, Luce, additional, Lanternier, Fanny, additional, LaPlante, Kerry L., additional, Lawn, Stephen D., additional, Lawrence, Steven J., additional, Leblebicioglu, Hakan, additional, Lee, Nelson, additional, Leggett, James E., additional, Lehours, Philippe, additional, Levy, Pierre-Yves, additional, Leyh, Rainer G., additional, Lillis, Rebecca A., additional, Limmathurotsakul, Direk, additional, Lin, Jennifer, additional, Lindquist, H.D. Alan, additional, Lipsky, Benjamin A., additional, Liscynesky, Christina, additional, Looney, David, additional, Lortholary, Olivier, additional, Lowy, Franklin D., additional, Luft, Benjamin J., additional, Mackowiak, Philip A., additional, MacPherson, Paul A., additional, Maghraoui-Slim, Valérie, additional, Mallon, Patrick W., additional, Mangino, Julie E., additional, Manuel, Oriol, additional, Marchetti, Oscar, additional, Marks, Kristen M., additional, Marr, Kieren A., additional, Marrazzo, Jeanne, additional, Marschall, Jonas, additional, Martin, David H., additional, Matonti, Frédéric, additional, Matulewicz, Richard S., additional, Mayer, Kenneth H., additional, McCulloh, Russell J., additional, McGready, Rose, additional, Mdodo, Rennatus, additional, Mead, Simon, additional, Mégraud, Francis, additional, Meintjes, Graeme, additional, Metcalf, Sarah C., additional, Michaels, Marian G., additional, Migliori, Giovanni Battista, additional, Miles, Michael A., additional, Miller, Alastair, additional, Mimiaga, Matthew J., additional, Mingeot-Leclercq, Marie-Paule, additional, Misch, Elizabeth Ann, additional, Mitreva, Makedonka, additional, Montaner, Julio S.G., additional, Moore, Caroline B., additional, Muñoz, Patricia, additional, Muñoz, Jose, additional, Murray, Clinton K., additional, Musso, Didier, additional, Mutengo, Mable, additional, Mutizwa, Misha M., additional, Naber, Kurt G., additional, Natarajan, Pavithra, additional, Neme, Santiago, additional, Newton, Paul N., additional, Nichols, Ronald A., additional, Nicolle, Lindsay E., additional, Nosten, François, additional, Notarangelo, Luigi D., additional, Nutman, Thomas B., additional, Nyirjesy, Paul, additional, O'Connell, P. Ronan, additional, Opal, Steven M., additional, Ormerod, L. Peter, additional, Osmon, Douglas R., additional, Pankert, Marie Boulze, additional, Pantaleo, Giuseppe, additional, Papazian, Laurent, additional, Parente, Diane M., additional, Parola, Philippe, additional, Parsaei, Shadi, additional, Pascual, Manuel A., additional, Patel, Rupa, additional, Patrozou, Eleni, additional, Pawlotsky, Jean-Michel, additional, Peacock, Sharon J., additional, Pechère, Jean-Claude, additional, Pelegrin, Ivan, additional, Peters, Barry S., additional, Peters, Edgar J.G., additional, Petersen, Jeannine M., additional, Petersen, Lyle R., additional, Petraitis, Vidmantas, additional, Pham, Luu-Ly, additional, Picado, Albert, additional, Pilatz, Adrian, additional, Pilmis, Benoit, additional, Pinazo, María-Jesús, additional, Pletz, Mathias W., additional, Pogue, Jason M., additional, Polgreen, Evelyn L., additional, Polgreen, Philip M., additional, Posfay-Barbe, Klara M., additional, Powderly, William G., additional, Presti, Rachel, additional, Prod'hom, Guy, additional, Puolakkainen, Mirja, additional, Quinn, Thomas C., additional, Raoult, Didier, additional, Razonable, Raymund R., additional, Read, Robert C., additional, Redfield, Robert R., additional, Rentenaar, Rob J., additional, Reynolds, Steven J., additional, Ribi, Camillo, additional, Richardson, Malcolm D., additional, Ritter, Michele L., additional, Roch, Antoine, additional, Rockstroh, Jürgen Kurt, additional, Rojek, Amanda, additional, Romero, José R., additional, Rooijakkers, Suzan H.M., additional, Rosenbluth, Daniel, additional, Rosenzweig, Sergio D., additional, Rossolini, Gian Maria, additional, Rubinstein, Ethan, additional, Ryan, Greg, additional, Safren, Steven A., additional, Sahasrabuddhe, Vikrant V., additional, Saikku, Pekka A.I., additional, Sajadi, Mohammad M., additional, Salvaggio, Michelle R., additional, Santos, Carlos A.Q., additional, Satlin, Michael J., additional, Schaeffer, Anthony J., additional, Schimmer, Christoph, additional, Schooley, Robert T., additional, Schumacher, Richard F., additional, Sha, Beverly E., additional, Shapiro, Daniel S., additional, Sheehan, Gerard, additional, Shlaes, David M., additional, Shoham, Shmuel, additional, Simmons, Cameron P., additional, Simon, Dennis W., additional, Simon, Matthew S., additional, Simonsen, Kari A., additional, Slack, Mary P.E., additional, Smith, Tyrel T., additional, Sobel, Jack D., additional, Souli, Maria, additional, Sridhar, Shruti, additional, Steckelberg, James M., additional, Stevens, Dennis L., additional, Strah, Heather, additional, Sturm, A. Willem, additional, Sungkanuparph, Somnuek, additional, Tabrizi, Sarah J., additional, Tacconelli, Evelina, additional, Tan, Chen Sabrina, additional, Taplitz, Randy A., additional, Thomas, Guillemette, additional, Thomas, Lora D., additional, Thuny, Franck, additional, Thwaites, Guy, additional, Tissot, Frederic, additional, Tønjum, Tone, additional, Torriani, Francesca J., additional, Toso, Christian, additional, Tulkens, Paul M., additional, Tunkel, Allan R., additional, Turner, Claire E., additional, Ustianowski, Andrew P., additional, van Bambeke, Françoise, additional, van Crevel, Reinout, additional, van de Beek, Diederik, additional, van Delden, Christian, additional, van der Eerden, Menno M., additional, van der Meer, Jos W.M., additional, van der Poll, Tom, additional, van Ingen, Jakko, additional, van Putten, Jos, additional, Vaudaux, Bernard P., additional, Vermund, Sten H., additional, Viscidi, Raphael P., additional, Visvanathan, Kumar, additional, Visvesvara, Govinda S., additional, von Seidlein, Lorenz, additional, Wagenlehner, Florian M.E., additional, Wald, Anna, additional, Walsh, Thomas J., additional, Warhurst, David C., additional, Warnock, David W., additional, Warrell, David A., additional, Warrell, Mary J., additional, Warris, Adilia, additional, Watkins, Richard R., additional, Weatherall, David J., additional, Weber, Rainer, additional, Weidner, Wolfgang, additional, White, Jonathan R., additional, White, Peter J., additional, Whitehorn, James, additional, Whitley, Richard J., additional, Whitty, Christopher J.M., additional, Wiersinga, Willem Joost, additional, Wilcox, Mark H., additional, Williams, Thomas N., additional, Wilson, Cara C., additional, Wilson, Mary Elizabeth, additional, Wisplinghoff, Hilmar, additional, Wood, Robin, additional, Wunderink, Richard G., additional, Wyles, David, additional, Yang, Zhi-Tao, additional, Yoder, Jonathan S., additional, Zaidi, Najam A., additional, Zimmer, Andrea J., additional, Zuckerman, Jane N., additional, and Zumla, Alimuddin, additional

Published
2017
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34. State-of-the-Art in the Drug Discovery Pathway for Chagas Disease: A Framework for Drug Development and Target Validation.

Author

Gabaldón-Figueira, Juan Carlos, Martinez-Peinado, Nieves, Escabia, Elisa, Ros-Lucas, Albert, Chatelain, Eric, Scandale, Ivan, Gascon, Joaquim, Pinazo, María-Jesús, and Alonso-Padilla, Julio

Subjects
CHAGAS' disease, DRUG discovery, DRUG development, DRUG target, PARASITE life cycles
Abstract

Chagas disease is the most important protozoan infection in the Americas, and constitutes a significant public health concern throughout the world. Development of new medications against its etiologic agent, Trypanosoma cruzi, has been traditionally slow and difficult, lagging in comparison with diseases caused by other kinetoplastid parasites. Among the factors that explain this are the incompletely understood mechanisms of pathogenesis of T. cruzi infection and its complex set of interactions with the host in the chronic stage of the disease. These demand the performance of a variety of in vitro and in vivo assays as part of any drug development effort. In this review, we discuss recent breakthroughs in the understanding of the parasite's life cycle and their implications in the search for new chemotherapeutics. For this, we present a framework to guide drug discovery efforts against Chagas disease, considering state-of-the-art preclinical models and recently developed tools for the identification and validation of molecular targets. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Results and evaluation of the expansion of a model of comprehensive care for Chagas disease within the National Health System: The Bolivian Chagas network

Author

Pinazo, Maria-Jesus, Rojas-Cortez, Mirko, Saravia, Ruth, Garcia-Ruiloba, Wilson, Ramos, Carlos, Pinto Rocha, Jimy-Jose, Ortiz, Lourdes, Castellon, Mario, Mendoza-Claure, Nilce, Lozano, Daniel, Torrico, Faustino, Gascon, Joaquim, Chagas Platform and, and Chagas Healthcare Network working group

Subjects
Bolívia, Bolivia, Antiparasitic Agents, National Health Programs, Health Personnel, Trypanosoma cruzi, Public Health, Environmental and Occupational Health, Primary care, Health Services Accessibility, Chagas' disease, Infectious Diseases, Malaltia de Chagas, Atenció primària, Diagnòstic, Diagnosis, Humans, Chagas Disease, Comprehensive Health Care
Abstract

Background Most people with chronic Chagas disease do not receive specific care and therefore are undiagnosed and do not receive accurate treatment. This manuscript discusses and evaluates a collaborative strategy to improve access to healthcare for patients with Chagas in Bolivia, a country with the highest prevalence of Chagas in the world. Methods With the aim of reinforcing the Chagas National Programme, the Bolivian Chagas Platform was born in 2009. The first stage of the project was to implement a vertical pilot program in order to introduce and consolidate a consensual protocol-based healthcare, working in seven centers (Chagas Platform Centers). From 2015 on the model was extended to 52 primary healthcare centers, through decentralized, horizontal scaling-up. To evaluate the strategy, we have used the WHO ExpandNet program. Results The strategy has significantly increased the number of patients cared for, with 181,397 people at risk of having T. cruzi infection tested and 57,871 (31·9%) new diagnostics performed. In those with treatment criteria, 79·2% completed the treatment. The program has also trained a significant number of health personnel through the specific Chagas guidelines (67% of healthcare workers in the intervention area). Conclusions After being recognized by the Chagas National Programme as a healthcare model aligned with national laws and priorities, the Bolivian platform of Chagas as an innovation, includes attributes that they have made it possible to expand the strategy at the national level and could also be adapted in other countries.

Published
2022

44. Genetic polymorphism of Trypanosoma cruzi bloodstream populations in adult chronic indeterminate Chagas disease patients from the E1224 clinical trial

Author

Ramírez, Juan Carlos, primary, Acevedo, Gonzalo Raúl, additional, Torres, Carolina, additional, Parrado, Rudy, additional, De La Barra, Anabelle, additional, Villarroel, Sandro, additional, García, Lineth, additional, Gascon, Joaquim, additional, Ortiz, Lourdes, additional, Torrico, Faustino, additional, Ribeiro, Isabela, additional, and Schijman, Alejandro Gabriel, additional

Published
2021
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45. New chemotherapy regimens and biomarkers for Chagas disease: the rationale and design of the TESEO study, an open-label, randomised, prospective, phase-2 clinical trial in the Plurinational State of Bolivia

Author

Alonso-Vega, Cristina, primary, Urbina, Julio A, additional, Sanz, Sergi, additional, Pinazo, María-Jesús, additional, Pinto, Jimy José, additional, Gonzalez, Virginia R, additional, Rojas, Gimena, additional, Ortiz, Lourdes, additional, Garcia, Wilson, additional, Lozano, Daniel, additional, Soy, Dolors, additional, Maldonado, Rosa A, additional, Nagarkatti, Rana, additional, Debrabant, Alain, additional, Schijman, Alejandro, additional, Thomas, M Carmen, additional, López, Manuel Carlos, additional, Michael, Katja, additional, Ribeiro, Isabela, additional, Gascon, Joaquim, additional, Torrico, Faustino, additional, and Almeida, Igor C, additional

Published
2021
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47. Screening for Mutations Related to Atovaquone/Proguanil Resistance in Treatment Failures and Other Imported Isolates of Plasmodium falciparum in Europe

Author

European Network on Surveillance of Imported Infectious Diseases, Wichmann, Ole, Muehlberger, Nikolai, Jelinek, Tomas, Alifrangis, Michael, Peyerl-Hoffmann, Gabriele, Mühlen, Marion, Grobusch, Martin P., Gascon, Joaquim, Matteelli, Alberto, Laferl, Hermann, Bisoffi, Zeno, Ehrhardt, Stephan, Cuadros, Juan, Hatz, Christoph, Gjørup, Ida, McWhinney, Paul, Beran, Jiři, da Cunha, Saraiva, Schulze, Marco, Kollaritsch, Herwig, Kern, Peter, Fry, Graham, and Richter, Joachim

Published
2004

49. Novel purine chemotypes with activity against Plasmodium 2 falciparum and Trypanosoma cruzi

Author

Martinez-Peinado, Nieves, Lorente Macias, Alvaro, Garcia-Salbuero, Alejandro, Cortes-Serra, Nuria, Fenollar-Collado, Angel, Ros-Lucas, Albert, Gascon, Joaquim, Pinazo, Maria-Jesus, Molina, Ignacio J., Unciti-Broceta, Asier, Díaz-Mochón, Juan J., Villatoro, Maria J. Pineda de las Infantas y, Izquierdo, Luis, and Alonso-Padilla, Julio

Subjects
Plasmodium Falciparum, parasitic diseases, cytotoxity assays, Trypanosome cruzi, purine metabolism, purine derivatives, pyrimidine analogs, phenotypic assays
Abstract

Malaria and Chagas disease, caused by Plasmodium spp. and Trypanosoma cruzi parasites, 25 remain an important global health problem. Available treatments for those diseases present several 26 limitations such as lack of efficacy, toxic side effects and drug resistance. Thus, finding new drugs 27 is urgently needed. The discovery of new drugs may be benefited by considering significant bio-28 logical differences between host and parasites. One of the most striking differences is found in the 29 purine metabolism because most of the parasites are incapable of de novo purine biosynthesis. 30 Herein, we have analyzed the in vitro anti-P. falciparum and anti-T. cruzi activity of a collection of 81 31 purine derivatives and pyrimidine analogs. We firstly used a primary screening at three fixed 32 concentrations (100, 10 and 1 μM) and progressed to dose-response assays those compounds that 33 kept the growth of the parasites < 30% at 100 μM. Then, we performed two different cytotoxicity 34 assays on Vero cells and human HepG2 cells. Finally, compounds specifically active against T. cruzi 35 were tested against intracellular amastigote forms. Purines 33 (IC50 = 19.19 μM) and 76 (IC50 = 18.27 36 μM) were the most potent against P. falciparum. On the other hand, 6D (IC50 = 3.78 μM) and 34 (IC50 37 = 4.24 μM) were identified as hit purines against T. cruzi amastigotes. Moreover, an in silico docking 38 study revealed that P. falciparum and T. cruzi hypoxanthine guanine phosphoribosyltransferase 39 enzymes could be the potential targets of those compounds. Our study identified two novel pu-40 rine-based chemotypes that can be further optimized to generate potent and diversified an-41 ti-parasitic drugs against both parasites.

Published
2021

50. Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the “Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions”

Author

Shikanai-Yasuda, Maria Aparecida, primary, Mediano, Mauro Felippe Felix, additional, Novaes, Christina Terra Gallafrio, additional, Sousa, Andréa Silvestre de, additional, Sartori, Ana Marli Christovam, additional, Santana, Rodrigo Carvalho, additional, Correia, Dalmo, additional, Castro, Cleudson Nery de, additional, Severo, Marilia Maria dos Santos, additional, Hasslocher-Moreno, Alejandro Marcel, additional, Fernandez, Marisa Liliana, additional, Salvador, Fernando, additional, Pinazo, Maria Jesús, additional, Bolella, Valdes Roberto, additional, Furtado, Pedro Carvalho, additional, Corti, Marcelo, additional, Neves Pinto, Ana Yecê, additional, Fica, Alberto, additional, Molina, Israel, additional, Gascon, Joaquim, additional, Viñas, Pedro Albajar, additional, Cortez-Escalante, Juan, additional, Ramos, Alberto Novaes, additional, and Almeida, Eros Antonio de, additional

Published
2021
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