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187 results on '"Gascoin, Géraldine"'

1. Prophylactic Intravenous Acetaminophen in Extremely Premature Infants: Minimum Effective Dose Research by Bayesian Approach

Author

Bouazza, Naïm, Cambonie, Gilles, Flamant, Cyril, Rideau, Aline, Tauzin, Manon, Patkai, Juliana, Gascoin, Géraldine, Lumia, Mirka, Aikio, Outi, Lui, Gabrielle, Bournaud, Léo Froelicher, Walsh-Papageorgiou, Aisling, Tortigue, Marine, Baruteau, Alban-Elouen, Kallio, Jaana, Hallman, Mikko, Diallo, Alpha, Levoyer, Léa, Treluyer, Jean-Marc, and Roze, Jean-Christophe

Published
2023
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2. Pulmonary hypertension among preterm infants born at 22 through 32 weeks gestation in France: Prevalence, survival, morbidity and management in the EPIPAGE-2 cohort study

Author

Breinig, Sophie, Ehlinger, Virginie, Rozé, Jean-Christophe, Storme, Laurent, Torchin, Heloise, Durrmeyer, Xavier, Cambonie, Gilles, Delacourt, Christophe, Jarreau, Pierre-Henri, Berthomieu, Lionel, Brissaud, Olivier, Benhammou, Valérie, Gascoin, Geraldine, Arnaud, Catherine, and Ancel, Pierre-Yves

Published
2023
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3. Neonatal outcomes for women at risk of preterm delivery given half dose versus full dose of antenatal betamethasone: a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial

Author

Boize, Philippe, Garabédian, Charles, Flamein, Florence, Le Lous, Maela, Beuchée, Alain, Gondry, Jean, Tourneux, Pierre, Coste-Mazeau, Perrine, Bedu, Antoine, Gallot, Denis, Coste, Karen, Chauleur, Céline, Patural, Hugues, Kayem, Gilles, Mitanchez, Delphine, Heckenroth, Hélène, Boubred, Farid, Sibiude, Jeanne, Desfrère, Luc, Bohec, Caroline, Mansir, Thierry, Koch, Antoine, Kuhn, Pierre, Tillouche, Nadia, Lapeyre, Fabrice, Perrotin, Franck, Favrais, Géraldine, Lecarpentier, Edouard, Durrmeyer, Xaxier, Equy, Véronique, Debillon, Thierry, Rigonnot, Luc, Lefoulgoc, Stéphanie, Brie, Claudia, Pagès, Anne-Sophie, Rayssiguier, Romy, Cambonie, Gilles, Cudeville, Corinne, Madeleneau, Doriane, Morel, Olivier, Hascoet, Jean-Michel, Letouzey, Vincent, Di Maio, Massimo, Salomon, Laurent J., Lapillonne, Alexandre, Schmitz, Thomas, Doret-Dion, Muriel, Sentilhes, Loic, Parant, Olivier, Claris, Olivier, Renesme, Laurent, Abbal, Julie, Girault, Aude, Torchin, Héloïse, Houllier, Marie, Le Saché, Nolwenn, Vivanti, Alexandre J, De Luca, Daniele, Winer, Norbert, Flamant, Cyril, Thuillier, Claire, Boileau, Pascal, Blanc, Julie, Brevaut, Véronique, Bouet, Pierre-Emmanuel, Gascoin, Géraldine, Beucher, Gaël, Datin-Dorriere, Valérie, Bounan, Stéphane, Bolot, Pascal, Poncelet, Christophe, Alberti, Corinne, Ursino, Moreno, Aupiais, Camille, and Baud, Olivier

Published
2022
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4. Tocolysis after preterm prelabor rupture of membranes and 5-year outcomes: a population-based cohort study

Author

Ancel, Pierre-Yves, Arnaud, Catherine, Arthuis, Chloé, Blanc, Julie, Boileau, Pascal, Debillon, Thierry, Delorme, Pierre, D’Ercole, Claude, Desplanches, Thomas, RM, PhD., Diguisto, Caroline, Foix-L’Hélias, Laurence, Gascoin, Géraldine, Gire, Catherine, Goffinet, François, Guellec, Isabelle, Kayem, Gilles, Langer, Bruno, Letouzey, Mathilde, Lorthe, Elsa, Maisonneuve, Emeline, Marret, Stéphane, Monier, Isabelle, Morgan, Andrei, Rozé, Jean-Christophe, Schmitz, Thomas, Sentilhes, Loïc, Subtil, Damien, Torchin, Héloïse, Tosello, Barthélémy, Vayssière, Christophe, Winer, Norbert, Zeitlin, Jennifer, Marchand-Martin, Laetitia, Aubert, Adrien M., Pierrat, Véronique, Benhammou, Valérie, and L’Hélias, Laurence Foix

Published
2024
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8. Birth weight and head circumference discordance and outcome in preterms: results from the EPIPAGE-2 cohort.

Author

Guellec, Isabelle, Brunet, Adelaide, Lapillonne, Alexandre, Taine, Marion, Torchin, Héloïse, Favrais, Geraldine, Gascoin, Géraldine, Simon, Laure, Heude, Barbara, Scherdel, Pauline, Kayem, Gilles, Delorme, Pierre, Jarreau, Pierre-Henri, and Ancel, Pierre-Yves

Subjects
CHORIOAMNIONITIS, BIRTH weight, PHYSIOLOGY, LOW birth weight, FETAL growth retardation, SMALL for gestational age
Published
2024
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9. Association of Chorioamnionitis with Cerebral Palsy at Two Years after Spontaneous Very Preterm Birth: The EPIPAGE-2 Cohort Study

Author

Arnaud, Catherine, Arthuis, Chloé, Blanc, Julie, Boileau, Pascal, Debillon, Thierry, D’Ercole, Claude, Desplanches, Thomas, Diguisto, Caroline, Garbi, Aurélie, Gascoin, Géraldine, Gire, Catherine, Langer, Bruno, Letouzey, Mathilde, Monier, RM, Isabelle, Morgan, Andrei, Rozé, Jean-Christophe, Schmitz, Thomas, Tosello, Barthélémy, Vayssiére, Christophe, Winer, Norbert, Zeitlin, Jennifer, Maisonneuve, Emeline, Lorthe, Elsa, Torchin, Héloïse, Delorme, Pierre, Devisme, Louise, L’Hélias, Laurence Foix, Marret, Stéphane, Subtil, Damien, Bodeau-Livinec, Florence, Pierrat, Véronique, Sentilhes, Loïc, Goffinet, François, Ancel, Pierre-Yves, and Kayem, Gilles

Published
2020
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10. Staphylococcus capitis isolated from bloodstream infections: a nationwide 3-month survey in 38 neonatal intensive care units

Author

Decalonne, Marie, Dos Santos, Sandra, Gimenes, Rémi, Goube, Florent, Abadie, Géraldine, Aberrane, Saïd, Ambrogi, Vanina, Baron, Raoul, Barthelemy, Patrick, Bauvin, Isabelle, Belmonte, Olivier, Benabid, Emilie, Ammar, Rafik Ben, Yahia, Salma Ben Hadj, Berrouane, Yasmina, Berthelot, Philippe, Beuchee, Alain, Bille, Emmanuelle, Bolot, Pascal, Bordes-Couecou, Stéphanie, Bouissou, Antoine, Bourdon, Sandra, Bourgeois-Nicolaos, Nadège, Boyer, Sophie, Cattoen, Christian, Cattoir, Vincent, Chaplain, Chantal, Chatelet, Céline, Claudinon, Aurore, Chautemps, Nathalie, Cormier, Hélène, Coroller-Bec, Céline, Cotte, Benjamin, De Chillaz, Carole, Dauwalder, Olivier, Davy, Aude, Delorme, Martine, Demasure, Maryvonne, Desfrere, Luc, Drancourt, Michel, Dupin, Clarisse, Faraut-Derouin, Véronique, Florentin, Arnaud, Forget, Virginie, Fortineau, Nicolas, Foucan, Tania, Frange, Pierre, Gambarotto, Karine, Gascoin, Géraldine, Gibert, Laure, Gilquin, Jacques, Glanard, Audrey, Grando, Jacqueline, Gravet, Alain, Guinard, Jérôme, Hery-Arnaud, Geneviève, Huart, Claire, Idri, Nadia, Jellimann, Jean-Marc, Join-Lambert, Olivier, Joron, Sylvie, Jouvencel, Philippe, Kempf, Marie, Ketterer-Martinon, Sophie, Khecharem, Mouna, Klosowski, Serge, Labbe, Franck, Lacazette, Adeline, Lapeyre, Fabrice, Larche, Jérôme, Larroude, Peggy, Le Pourhiennec, Anne, Le Sache, Nolwenn, Ledru, Sylvie, Lefebvre, Annick, Legeay, Clément, Lemann, Florence, Lesteven, Claire, Levast-Raffin, Marion, Leyssene, David, Ligi, Isabelle, Lozniewski, Alain, Lureau, Pierre, Mallaval, Franck-Olivier, Malpote, Edith, Marret, Stéphane, Martres, Pascale, Menard, Guillaume, Menvielle, Laura, Mereghetti, Laurent, Merle, Véronique, Minery, Pascale, Morange, Virginie, Mourdie, Julien, Muggeo, Anaelle, Nakhleh, Jean, Noulard, Marie-Noëlle, Olive, Claude, Patural, Hugues, Penn, Pascale, Petitfrere, Manuel, Pozetto, Bruno, Riviere, Brigitte, Robine, Audrey, Ceschin, Christine Roques, Ruimy, Raymond, Siali, Amine, Soive, Stéphanie, Slimani, Souad, Trentesaux, Anne-Sophie, Trivier, Dominique, Vandenbussche, Christian, Villeneuve, Laurent, Werner, Evelyne, Le Vu, Stéphane, and Van Der Mee-Marquet, Nathalie

Published
2020
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13. Prophylactic Intravenous Acetaminophen in Extremely Premature Infants: Minimum Effective Dose Research by Bayesian Approach.

Author

Bouazza, Naïm, Cambonie, Gilles, Flamant, Cyril, Rideau, Aline, Tauzin, Manon, Patkai, Juliana, Gascoin, Géraldine, Lumia, Mirka, Aikio, Outi, Lui, Gabrielle, Bournaud, Léo Froelicher, Walsh-Papageorgiou, Aisling, Tortigue, Marine, Baruteau, Alban-Elouen, Kallio, Jaana, Hallman, Mikko, Diallo, Alpha, Levoyer, Léa, Treluyer, Jean-Marc, and Roze, Jean-Christophe

Subjects
ACETAMINOPHEN, PREMATURE infants, NEONATAL intensive care units, DIASTOLIC blood pressure, PLACENTAL growth factor, PATENT ductus arteriosus, SYSTOLIC blood pressure, ASPARTATE aminotransferase
Abstract

Background: Patent ductus arteriosus (PDA) in preterm infants is associated with increased morbidities and mortality. Prophylactic treatment with cyclooxygenase inhibitors, as indomethacin or ibuprofen, failed to demonstrate significant clinical benefits. Acetaminophen may represent an alternative treatment option. Objective: This study evaluated the minimum effective dose of prophylactic acetaminophen to close the ductus and assessed the safety and tolerability profile in extremely preterm infants at 23–26 weeks of gestation. Methods: A dose finding trial with Bayesian continual reassessment method was performed in a multicenter study with premature infants hospitalized in neonatal intensive care unit. Infants of 23–26 weeks of gestation and post-natal age ≤ 12 h were enrolled. Four intravenous acetaminophen dose levels were predefined. The primary outcome was the ductus arteriosus closing at two consecutive echocardiographies or at day 7. The main secondary objectives included the safety of acetaminophen on hemodynamics and biological hepatic function. Results: A total of 29 patients were analyzed sequentially for the primary analysis with 20 infants assigned to the first dose level followed by 9 infants to the second dose level. No further dose level increase was necessary. The posterior probabilities of success, estimated from the Bayesian logistic model, were 46.1% [95% probability interval (PI), 24.9–63.9] and 67.6% (95% PI, 51.5–77.9) for dose level 1 and 2, respectively. A closing or closed pattern was observed among 19 patients at the end of treatment [65.5% (95% confidence interval (CI), 45.7–82.0)]. No change in alanine aminotransferase values was observed during treatment. A significant decrease in aspartate aminotransferase values was observed with postnatal age. No change in systolic and diastolic blood pressures was observed during treatment. Conclusions: Minimum effective dose to close the ductus was 25 mg/kg loading dose then 10 mg/kg/6 h for 5 days in extremely preterm infants. Acetaminophen was well tolerated in this study following these doses. Trial Registration: ClinicalTrials.gov Identifier: NCT04459117. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Pan-Genomic Regulation of Gene Expression in Normal and Pathological Human Placentas

Author

Apicella, Clara, primary, Ruano, Camino S. M., additional, Thilaganathan, Basky, additional, Khalil, Asma, additional, Giorgione, Veronica, additional, Gascoin, Géraldine, additional, Marcellin, Louis, additional, Gaspar, Cassandra, additional, Jacques, Sébastien, additional, Murdoch, Colin E., additional, Miralles, Francisco, additional, Méhats, Céline, additional, and Vaiman, Daniel, additional

Published
2023
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16. Neonatal outcomes for women at risk of preterm delivery given half dose versus full dose of antenatal betamethasone: a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial

Author

Schmitz, Thomas, primary, Doret-Dion, Muriel, additional, Sentilhes, Loic, additional, Parant, Olivier, additional, Claris, Olivier, additional, Renesme, Laurent, additional, Abbal, Julie, additional, Girault, Aude, additional, Torchin, Héloïse, additional, Houllier, Marie, additional, Le Saché, Nolwenn, additional, Vivanti, Alexandre J, additional, De Luca, Daniele, additional, Winer, Norbert, additional, Flamant, Cyril, additional, Thuillier, Claire, additional, Boileau, Pascal, additional, Blanc, Julie, additional, Brevaut, Véronique, additional, Bouet, Pierre-Emmanuel, additional, Gascoin, Géraldine, additional, Beucher, Gaël, additional, Datin-Dorriere, Valérie, additional, Bounan, Stéphane, additional, Bolot, Pascal, additional, Poncelet, Christophe, additional, Alberti, Corinne, additional, Ursino, Moreno, additional, Aupiais, Camille, additional, Baud, Olivier, additional, Boize, Philippe, additional, Garabédian, Charles, additional, Flamein, Florence, additional, Le Lous, Maela, additional, Beuchée, Alain, additional, Gondry, Jean, additional, Tourneux, Pierre, additional, Coste-Mazeau, Perrine, additional, Bedu, Antoine, additional, Gallot, Denis, additional, Coste, Karen, additional, Chauleur, Céline, additional, Patural, Hugues, additional, Kayem, Gilles, additional, Mitanchez, Delphine, additional, Heckenroth, Hélène, additional, Boubred, Farid, additional, Sibiude, Jeanne, additional, Desfrère, Luc, additional, Bohec, Caroline, additional, Mansir, Thierry, additional, Koch, Antoine, additional, Kuhn, Pierre, additional, Tillouche, Nadia, additional, Lapeyre, Fabrice, additional, Perrotin, Franck, additional, Favrais, Géraldine, additional, Lecarpentier, Edouard, additional, Durrmeyer, Xaxier, additional, Equy, Véronique, additional, Debillon, Thierry, additional, Rigonnot, Luc, additional, Lefoulgoc, Stéphanie, additional, Brie, Claudia, additional, Pagès, Anne-Sophie, additional, Rayssiguier, Romy, additional, Cambonie, Gilles, additional, Cudeville, Corinne, additional, Madeleneau, Doriane, additional, Morel, Olivier, additional, Hascoet, Jean-Michel, additional, Letouzey, Vincent, additional, Di Maio, Massimo, additional, Salomon, Laurent J., additional, and Lapillonne, Alexandre, additional

Published
2022
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17. Delivery Mode After Manual Rotation of Occiput Posterior Fetal Positions

Author

Verhaeghe, Caroline, Corroenne, Romain, Spiers, Andrew, Descamps, Philippe, Gascoin, Géraldine, Bouet, Pierre-Emmanuel, Parot-Schinkel, Elsa, and Legendre, Guillaume

Subjects
mental disorders, Contents, reproductive and urinary physiology, Original Research
Abstract

Manual rotation of fetuses in occiput posterior positions at the start of the second stage of labor does not increase the rate of spontaneous vaginal delivery., OBJECTIVE: To evaluate whether manual rotation of fetuses in occiput posterior positions at full dilation increases the rate of spontaneous vaginal delivery. METHODS: In an open, single-center, randomized controlled trial, patients with a term, singleton gestation, epidural analgesia, and ultrasonogram-confirmed occiput posterior position at the start of the second stage of labor were randomized to either manual rotation or expectant management. Our primary endpoint was the rate of spontaneous vaginal delivery. Secondary endpoints were operative vaginal delivery, cesarean delivery, and maternal and neonatal morbidity. Analyses were based on an intention-to-treat method. A sample size of 107 patients per group (n=214) was planned to detect a 20% increase in the percent of patients with a spontaneous vaginal delivery (assuming 60% without manual rotation vs 80% with manual rotation) with 90% power and alpha of 0.05. RESULTS: Between February 2017 and January 2020, 236 patients were randomized to either manual rotation (n=117) or expectant management (n=119). The success rate of the manual rotation maneuver, defined by conversion to an anterior position as confirmed by ultrasonogram, was 68%. The rate of the primary endpoint did not differ between the groups (58.1% in manual rotation group vs 59.7% in expectant management group (risk difference −1.6; 95% CI −14.1 to 11.0). Manual rotation did not decrease the rate of operative vaginal delivery (29.9% in manual rotation group vs 33.6% in expectant management group (risk difference −3.7; 95% CI −16.6 to 8.2) nor the rate of cesarean delivery (12.0% in manual rotation group vs 6.7% in expectant management group (risk difference 5.3; 95% CI −2.2 to 12.6). Maternal and neonatal morbidity was also similar across the two groups. CONCLUSION: Manual rotation of occiput posterior positions at the start of second stage of labor does not increase the rate of vaginal delivery without instrumental assistance. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT03009435.

Published
2021

18. In-hospital Outcomes and Early Hemodynamic Management According to Echocardiography Use in Hypotensive Preterm Infants: A National Propensity-Matched Cohort Study

Author

Raschetti, Roberto, primary, Torchin, Héloïse, additional, Marchand-Martin, Laetitia, additional, Gascoin, Géraldine, additional, Cambonie, Gilles, additional, Brissaud, Olivier, additional, Rozé, Jean-Christophe, additional, Storme, Laurent, additional, Ancel, Pierre-Yves, additional, Mekontso-Dessap, Armand, additional, and Durrmeyer, Xavier, additional

Published
2022
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19. A Prospective Observational Study to Assess Attachment Representations With Regard to Neurocognitive and Behavioral Outcomes in Children Born Very Prematurely in the Loire Infant Follow-Up Team (LIFT Cohort)

Author

Riquin, Elise, primary, Sandnes, Ramona, additional, Bacro, Fabien, additional, Vinay, Aubeline, additional, Miljkovitch, Raphaële, additional, Rouger, Valérie, additional, Rakotonjanahary, Josué, additional, Gascoin, Géraldine, additional, and Müller, Jean-Baptiste, additional

Published
2022
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20. A Metabolomic Profiling of Intra-Uterine Growth Restriction in Placenta and Cord Blood Points to an Impairment of Lipid and Energetic Metabolism

Author

Chao de la Barca, Juan Manuel, primary, Chabrun, Floris, additional, Lefebvre, Tiphaine, additional, Roche, Ombeline, additional, Huetz, Noémie, additional, Blanchet, Odile, additional, Legendre, Guillaume, additional, Simard, Gilles, additional, Reynier, Pascal, additional, and Gascoin, Géraldine, additional

Published
2022
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24. Antibiotic prophylaxis in preterm premature rupture of membranes at 24–31 weeks’ gestation: Perinatal and 2‐year outcomes in the EPIPAGE‐2 cohort

Author

Lorthe, Elsa, Letouzey, Mathilde, Torchin, Héloïse, Foix L'Helias, Laurence, Gras‐le Guen, Christèle, Benhammou, Valérie, Boileau, Pascal, Charlier, Caroline, Kayem, Gilles, Ancel, Pierre‐yves, Arnaud, Catherine, Blanc, Julie, Debillon, Thierry, Delorme, Pierre, D’ercole, Claude, Desplanches, Thomas, Diguisto, Caroline, Gascoin, Géraldine, Gire, Catherine, Goffinet, François, Langer, Bruno, Maisonneuve, Emeline, Marret, Stéphane, Monier, Isabelle, Morgan, Andrei, Rozé, Jean‐christophe, Schmitz, Thomas, Sentilhes, Loïc, Subtil, Damien, Tosello, Barthélémy, Vayssière, Christophe, Winer, Norbert, Zeitlin, Jennifer, Astruc, D, Kuhn, P, Matis, J, Ramousset, C, Hernandorena, X, Chabanier, P, Joly‐pedespan, L, Costedoat, Mj, Leguen, A, Lecomte, B, Lemery, D, Vendittelli, F, Beucher, G, Dreyfus, M, Guillois, B, Toure, Y, Burguet, A, Couvreur, S, Gouyon, Jb, Sagot, P, Colas, N, Sizun, J, Beuchée, A, Pladys, P, Rouget, F, Dupuy, Rp, Soupre, D, Charlot, F, Roudaut, S, Favreau, A, Saliba, E, Reboul, L, Bednarek, N, Morville, P, Verrière, V, Thiriez, G, Balamou, C, Marpeau, L, Barbier, C, Durrmeyer, X, Granier, M, Ayoubi, M, Baud, O, Carbonne, B, Jarreau, Ph, Mitanchez, D, Duffaut, C, Cornu, L, Moras, R, Boulot, P, Cambonie, G, Daudé, H, Badessi, A, Tsaoussis, N, Bédu, A, Mons, F, Bahans, C, Binet, Mh, Fresson, J, Hascoët, Jm, Milton, A, Morel, O, Vieux, R, Hilpert, L, Alberge, C, Baron, M, Charkaluk, Ml, Pierrat, V, Truffert, P, Akowanou, S, Simeoni, U, Bongain, A, Deschamps, M, Branger, B, Rouger, V, Dupont, C, Gondry, Jean, Krim, G, Baby, B, Debeir, M, Claris, O, Picaud, Jc, Rubio‐gurung, S, Cans, C, Ego, A, Patural, H, Rannaud, A, Janky, E, Poulichet, A, Rosenthal, Jm, Coliné, E, Favre, A, Joly, N, Châlons, S, Pignol, J, Laurence, Pl, Robillard, Py, Samperiz, S, Ramful, D, Blondel, B, Bonet, M, Brinis, A, Coquelin, A, Durox, M, Kaminski, M, Khemache, K, Khoshnood, B, Lebeaux, C, Marchand‐martin, L, Rousseau, J, Saurel‐cubizolles, Mj, Tran, D, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy], Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier universitaire de Nantes (CHU Nantes), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Unité de Parasitologie-Mycologie, Service de Microbiologie [Hôpital Necker-Enfants-Malades, Paris], Assistance Publique - Hôpitaux de Paris, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service Epidémiologie clinique et santé publique [CHU Toulouse], Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Unité de biostatistiques [Centre Georges-François Leclerc], Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Médecine Néonatale et Réanimation Pédiatrique CHU Grenoble, CHU Grenoble, Service de gynécologie-obstétrique [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Service de Gynécologie Obstétrique, Médecine Foetale et Stérilité Conjugale - Chirurgie Gynécologie et Oncologique [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Service de Néonatologie, Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Recherches épidémiologiques en santé périnatale et santé des femmes, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), Groupe de Recherche sur l'Analyse Multimodale de la Fonction Cérébrale - UMR INSERM_S 1105 (GRAMFC), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Amiens-Picardie, Funding information:This work was partly supported by a postdoctoral grant from the Fondation des Treilles to EL. EPIPAGE-2 was funded by the French Institute of Public Health Research (IRESP TGIR 2009-01 programme)/Institute of Public Health and its partners: the French Health Ministry, the National Institute of Health and Medical Research (INSERM), the National Institute of Cancer, and the National Solidarity Fund for Autonomy (CNSA), the National Research Agency through the French EQUIPEX programme of investments for the future (grant number ANR-11-EQPX-0038), and the PREMUP Foundation. Additional funding was obtained from Fondation pour la Recherche Medicale (grant number SPF 20160936356) and Fondation de France (grant numbers 00050329, Grand Prix R18202KK]). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript., ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Education, Formation, Travail, Savoirs (EFTS), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), Centre Hospitalier Universitaire [Grenoble] (CHU), Modélisation et Évaluation des données complexes en Santé Publique (TIMC-MESP), Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), CHU Dijon, Hôpital Nord [CHU - APHM], Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Department of Obstetrics and Gynecology, Les Hôpitaux Universitaires de Strasbourg (HUS), EPIPAGE-2 Study Group, and Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Fetal Membranes, Premature Rupture, obstetric intervention, [SDV]Life Sciences [q-bio], Gestational Age, antenatal management, Cohort Studies, Pregnancy, Escherichia coli, Humans, Prospective Studies, latency, amoxicillin, neurodevelopment, macrolides, prematurity, Infant, Newborn, Pregnancy Outcome, Obstetrics and Gynecology, Infant, prophylactic antibiotics, Antibiotic Prophylaxis, Anti-Bacterial Agents, perinatal outcome, cephalosporins, Premature Birth, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neonatal Sepsis, Infant, Premature
Abstract

To compare different antibiotic prophylaxis administered after preterm premature rupture of membranes to determine whether any were associated with differences in obstetric and/or neonatal outcomes and/or neurodevelopmental outcomes at 2 years of corrected age.Prospective, nationwide, population-based EPIPAGE-2 cohort study of preterm infants.France, 2011.We included 492 women with a singleton pregnancy and a diagnosis of preterm premature rupture of membranes at 24-31 weeks. Exclusion criteria were contraindication to expectant management or indication for antibiotic therapy other than preterm premature rupture of membranes. Antibiotic prophylaxis was categorised as amoxicillin (n = 345), macrolide (n = 30), third-generation cephalosporin (n = 45) or any combinations covering Streptococcus agalactiae and90% of Escherichia coli (n = 72), initiated within 24 hours after preterm premature rupture of membranes.Population-averaged robust Poisson models.Survival at discharge without severe neonatal morbidity, 2-year neurodevelopment.With amoxicillin, macrolide, third-generation cephalosporin and combinations, 78.5%, 83.9%, 93.6% and 86.0% of neonates were discharged alive without severe morbidity. The administration of third-generation cephalosporin or any E. coli-targeting combinations was associated with improved survival without severe morbidity (adjusted risk ratio 1.25 [95% confidence interval 1.08-1.45] and 1.10 [95 % confidence interval 1.01-1.20], respectively) compared with amoxicillin. We evidenced no increase in neonatal sepsis related to third-generation cephalosporin-resistant pathogen.In preterm premature rupture of membranes at 24-31 weeks, antibiotic prophylaxis based on third-generation cephalosporin may be associated with improved survival without severe neonatal morbidity when compared with amoxicillin, with no evidence of increase in neonatal sepsis related to third-generation cephalosporin-resistant pathogen.Antibiotic prophylaxis after PPROM at 24-31 weeks: 3rd-generation cephalosporins associated with improved neonatal outcomes.

Published
2022

27. In Reply

Author

Verhaeghe, Caroline, primary, Corroenne, Romain, additional, Spiers, Andrew, additional, Descamps, Philippe, additional, Gascoin, Géraldine, additional, Bouet, Pierre-Emmanuel, additional, Parot-Schinkel, Elsa, additional, and Legendre, Guillaume, additional

Published
2021
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29. Neurodevelopmental outcomes at age 5 among children born preterm: EPIPAGE-2 cohort study

Author

Pierrat, Véronique, Marchand-Martin, Laetitia, Marret, Stéphane, Arnaud, Catherine, Benhammou, Valérie, Cambonie, Gilles, Debillon, Thierry, Dufourg, Marie-Noëlle, Gire, Catherine, Goffinet, François, Kaminski, Monique, Lapillonne, Alexandre, Morgan, Andrei Scott, Rozé, Jean-Christophe, Twilhaar, Sabrina, Charles, Marie-Aline, Ancel, Pierre-Yves, Langer, Bruno, Matis, Jacqueline, Kuhn, Pierre, Rebola, Muriel, Renesme, Laurent, Joly, Laurent, Lecomte, Benedicte, Datin-Dorriere, Valerie, Guillois, Bernard, Burguet, Antoine, Semama, Denis, Roué, Jean-Michel, Bretaudeau, Gilles, Rouget, Florence, Saliba, Elie, Favaris, Géraldine, Bednarek, Nathalie, Loron, Gauthier, Thiriez, Gerard, Chadie, Alexandra, de la Villéon, Gaëlle, Durrmeyer, Xavier, Granier, Michèle, Boileau, Pascal, Kayem, Gilles, Jarreau, Pierre-Henri, Foix-L’Hélias, Laurence, Boulot, Pierre, Daudé, Hubert, Bédu, Antoine, Mons, Fabienne, Deforge, Hélène, Fresson, Jeanne, Vayssière, Christophe, Breinig, Sophie, Truffert, Patrick, Nuytten, Alexandra, Charkaluk, Marie Laure, Brevaut, Veronique, Zahed, Meriem, Garcia, Patricia, Fayol, Laurence, Flamant, Cyril, Muller, Jean-Baptiste, Gascoin, Géraldine, Leke, André, Fontaine, Cécile, Claris, Olivier, Picaud, Jean-Charles, Ego, Anne, Patural, Hughes, Poulichet, Anne, Abrial, Aude, Favre, Anne, Fléchelles, Olivier, Ramful, Duksha, Carbonnier, Magali, Simeon, Thierry, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University College of London [London] (UCL), CHU Rouen, Normandie Université (NU), MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC ), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Etude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS) (ELFE), Institut national d'études démographiques (INED)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance Publique - Hôpitaux de Marseille (APHM), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Paris (UP), Centre hospitalier universitaire de Nantes (CHU Nantes), CIC - Mère Enfant Necker Cochin Paris Centre (CIC 1419), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), French Institute of Public Health Research/Institute of Public HealthFrench Health MinistryPREMUP FoundationFondation de France11779Foundation for Medical ResearchSPF20160936356hospital clinical research programme EpinutriDGOS13-040Institut National de la Sante et de la Recherche Medicale (Inserm)National Institute of CancerNational Solidarity Fund for Autonomy (CNSA), ANR-11-EQPX-0038,RE-CO-NAI,Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance(2011), Paris Diderot, Equipe HAL, Equipements d'excellence - Plateforme de REcherche sur les COhortes d'enfants suivis depuis la NAIssance - - RE-CO-NAI2011 - ANR-11-EQPX-0038 - EQPX - VALID, Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université des Antilles (UA)-Etablissement français du don du sang [Montpellier], Modélisation et Évaluation des données complexes en Santé Publique (TIMC-MESP), Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Paris Cité (UPCité), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)

Subjects
Male, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Research, [SDV]Life Sciences [q-bio], Age Factors, Infant, Newborn, Gestational Age, Infant, Premature, Diseases, Cohort Studies, [SDV] Life Sciences [q-bio], Child Development, Neurodevelopmental Disorders, Case-Control Studies, Child, Preschool, Humans, Female, France, Infant, Premature, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Abstract Objectives To describe neurodevelopment at age 5 among children born preterm. Design Population based cohort study, EPIPAGE-2. Setting France, 2011. Participants 4441 children aged 5½ born at 24-26, 27-31, and 32-34 weeks Main outcome measures Severe/moderate neurodevelopmental disabilities, defined as severe/moderate cerebral palsy (Gross Motor Function Classification System (GMFCS) ≥2), or unilateral or bilateral blindness or deafness, or full scale intelligence quotient less than minus two standard deviations (Wechsler Preschool and Primary Scale of Intelligence, 4th edition). Mild neurodevelopmental disabilities, defined as mild cerebral palsy (GMFCS-1), or visual disability ≥3.2/10 and

Published
2021

31. Quiet Sleep Organization of Very Preterm Infants Is Correlated With Postnatal Maturation

Author

Cailleau, Léa, Weber, Raphael, Cabon, Sandie, Flamant, Cyril, Roué, Jean-Michel, Favrais, Géraldine, Gascoin, Géraldine, Thollot, Aurore, Esvan, Maxime, Porée, Fabienne, Pladys, Patrick, CHU Pontchaillou [Rennes], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Horizon 2020, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), and Jonchère, Laurent

Subjects
[SDV.IB] Life Sciences [q-bio]/Bioengineering, visualization software, maturation, [SDV.IB]Life Sciences [q-bio]/Bioengineering, annotation software, sleep, video, Pediatrics, Original Research, preterm infant
Abstract

International audience; Background: Sleep is an important determinant of brain development in preterm infants. Its temporal organization varies with gestational age (GA) and post-menstrual age (PMA) but little is known about how sleep develops in very preterm infants. The objective was to study the correlation between the temporal organization of quiet sleep (QS) and maturation in premature infants without severe complications during their neonatal hospitalization. Methods: Percentage of time spent in QS and average duration of time intervals (ADI) spent in QS were analyzed from a cohort of newborns with no severe complications included in the Digi-NewB prospective, multicentric, observational study in 2017-19. Three groups were analyzed according to GA: Group 1 (27-30 weeks), Group 2 (33-37 weeks), Group 3 (>39 weeks). Two 8-h video recordings were acquired in groups 1 and 2: after birth (T1) and before discharge from hospital (T2). The annotation of the QS phases was performed by analyzing video recordings together with heart rate and respiratory traces thanks to a dedicated software tool of visualization and annotation of multimodal long-time recordings, with a double expert reading. Results are expressed as median (interquartile range, IQR). Correlations were analyzed using a linear mixed model. Results: Five newborns were studied in each group (160 h of recording). Median time spent in QS increased from 13.0% [IQR: 13-20] to 28.8% [IQR: 27-30] and from 17.0% [IQR: 15-21] to 29.6% [IQR: 29.5-31.5] in Group 1 and 2, respectively. Median ADI increased from 54 [IQR: 53-54] to 288 s [IQR: 279-428] and from 90 [IQR: 84-96] to 258 s [IQR: 168-312] in Group 1 and 2. Both groups reach values similar to that of group 3, respectively 28.2% [IQR: 24.5-31.3] and 270 s [IQR: 210-402]. The correlation between PMA and time spent in QS or ADI were, respectively 0.73 (p < 10-4) and 0.46 (p = 0.06). Multilinear analysis using temporal organization of QS gave an accurate estimate of PMA (r 2 = 0.87, p < 0.001). Conclusion: The temporal organization of QS is correlated with PMA in newborns without severe complication. An automated standardized continuous behavioral quantification of QS could be interesting to monitor during the hospitalization stay in neonatal units.

Published
2020

32. Association between extremely preterm caesarean delivery and maternal depressive and anxious symptoms: a national population‐based cohort study

Author

Blanc, J, primary, Rességuier, N, additional, Lorthe, E, additional, Goffinet, F, additional, Sentilhes, L, additional, Auquier, P, additional, Tosello, B, additional, d'Ercole, C, additional, Ancel, Pierre‐Yves, additional, Arnaud, Catherine, additional, Blanc, Julie, additional, Boileau, Pascal, additional, Debillon, Thierry, additional, Delorme, Pierre, additional, D’Ercole, Claude, additional, Desplanches, Thomas, additional, Diguisto, Caroline, additional, Foix‐L’Hélias, Laurence, additional, Garbi, Aurélie, additional, Gascoin, Géraldine, additional, Gaudineau, Adrien, additional, Gire, Catherine, additional, Goffinet, François, additional, Kayem, Gilles, additional, Langer, Bruno, additional, Letouzey, Mathilde, additional, Lorthe, Elsa, additional, Maisonneuve, Emeline, additional, Marret, Stéphane, additional, Monier, Isabelle, additional, Morgan, Andrei, additional, Rozé, Jean‐Christophe, additional, Schmitz, Thomas, additional, Sentilhes, Loïc, additional, Subtil, Damien, additional, Torchin, Héloïse, additional, Tosello, Barthélémy, additional, Vayssière, Christophe, additional, Winer, Norbert, additional, and Zeitlin, Jennifer, additional

Published
2020
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33. In utero exposure to Azathioprine in autoimmune disease. Where do we stand?

Author

Belizna, Cristina, primary, Meroni, Pier Luigi, additional, Shoenfeld, Yehuda, additional, Devreese, Katrien, additional, Alijotas-Reig, Jaume, additional, Esteve-Valverde, Enrique, additional, Chighizola, Cecilia, additional, Pregnolato, Francesca, additional, Cohen, Hannah, additional, Fassot, Celine, additional, Mattera, Patrick Martin, additional, Peretti, Pascale, additional, Levy, Alexandre, additional, Bernard, Laurence, additional, Saiet, Mathilde, additional, Lagarce, Laurence, additional, Briet, Marie, additional, Rivière, Marianne, additional, Pellier, Isabelle, additional, Gascoin, Géraldine, additional, Rakotonjanahary, Jose, additional, Borghi, Maria Orietta, additional, Stojanovich, Ljudmila, additional, Djokovic, Aleksandra, additional, Stanisavljevic, Natasa, additional, Bromley, Rebecca, additional, Elefant-Amoura, Elisabeth, additional, Bahi Buisson, Nadia, additional, Pindi Sala, Taylor, additional, Kelchtermans, Hilde, additional, Makatsariya, Alexander, additional, Bidsatze, Viktoria, additional, Khizroeva, Jamilya, additional, Latino, Jose Omar, additional, Udry, Sebastian, additional, Henrion, Daniel, additional, Loufrani, Laurent, additional, Guihot, Anne Laure, additional, Muchardt, Christian, additional, Hasan, Milena, additional, Ungeheuer, Marie Noelle, additional, Voswinkel, Jan, additional, Damian, Laura, additional, Pabinger, Ingrid, additional, Gebhart, Johanna, additional, Lopez Pedrera, Rosario, additional, Cohen Tervaert, Jan Willem, additional, Tincani, Angela, additional, and Andreoli, Laura, additional

Published
2020
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34. Association of Chorioamnionitis with Cerebral Palsy at Two Years after Spontaneous Very Preterm Birth: The EPIPAGE-2 Cohort Study

Author

Maisonneuve, Emeline, primary, Lorthe, Elsa, additional, Torchin, Héloïse, additional, Delorme, Pierre, additional, Devisme, Louise, additional, L’Hélias, Laurence Foix, additional, Marret, Stéphane, additional, Subtil, Damien, additional, Bodeau-Livinec, Florence, additional, Pierrat, Véronique, additional, Sentilhes, Loïc, additional, Goffinet, François, additional, Ancel, Pierre-Yves, additional, Kayem, Gilles, additional, Arnaud, Catherine, additional, Arthuis, Chloé, additional, Blanc, Julie, additional, Boileau, Pascal, additional, Debillon, Thierry, additional, D’Ercole, Claude, additional, Desplanches, Thomas, additional, Diguisto, Caroline, additional, Garbi, Aurélie, additional, Gascoin, Géraldine, additional, Gire, Catherine, additional, Langer, Bruno, additional, Letouzey, Mathilde, additional, Monier, RM, Isabelle, additional, Morgan, Andrei, additional, Rozé, Jean-Christophe, additional, Schmitz, Thomas, additional, Tosello, Barthélémy, additional, Vayssiére, Christophe, additional, Winer, Norbert, additional, and Zeitlin, Jennifer, additional

Published
2020
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35. Potential Impact of Umbilical-Cord-Blood Procalcitonin-Based Algorithm on Antibiotics Exposure in Neonates With Suspected Early-Onset Sepsis

Author

Huetz, Noémie, primary, Launay, Elise, additional, Gascoin, Géraldine, additional, Leboucher, Bertrand, additional, Savagner, Christophe, additional, Muller, Jean B., additional, Denizot, Sophie, additional, Boscher, Cécile, additional, Caillon, Jocelyne, additional, Masson, Damien, additional, and Gras Le Guen, Christèle, additional

Published
2020
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36. Neonatal and neurodevelopmental outcomes in preterm infants according to maternal body mass index: A prospective cohort study

Author

Moreau, Marie, primary, Remy, Mathilde, additional, Nusinovici, Simon, additional, Rouger, Valérie, additional, Molines, Lisa, additional, Flamant, Cyril, additional, Legendre, Guillaume, additional, Roze, Jean-Christophe, additional, Salle, Agnès, additional, Van Bogaert, Patrick, additional, Coutant, Régis, additional, and Gascoin, Géraldine, additional

Published
2019
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37. Neonatal Outcomes for Women at Risk of Preterm Delivery Given Half Dose Versus Full Dose of Antenatal Betamethasone: A Randomized, Multicentre, Double-blind, Placebo-Controlled, Non-inferiority Trial

Author

Schmitz, Thomas, Doret-Dion, Muriel, Sentilhes, Loic, Parant, Olivier, Claris, Olivier, Renesme, Laurent, Abbal, Julie, Girault, Aude, Torchin, Héloïse, Houllier, Marie, Le Saché, Nolwenn, Vivanti, Alexandre J., De Luca, Daniele, Winer, Norbert, Flamant, Cyril, Thuillier, Claire, Boileau, Pascal, Blanc, Julie, Brevaut, Véronique, Bouet, Pierre-Emmanuel, Gascoin, Géraldine, Beucher, Gaël, Datin-Dorriere, Valérie, Bounan, Stéphane, Bolot, Pascal, Poncelet, Christophe, Alberti, Corinne, Ursino, Moreno, Aupiais, Camille, and Baud, Olivier

Abstract

Antenatal corticosteroid administration to women at risk of preterm delivery is recommended worldwide because of their effectiveness in preventing respiratory distress syndrome, as well as in reducing the rate of necrotizing enterocolitis, intraventricular hemorrhage, and neonatal death in preterm infants. However, the current usual dosage regimen of 2 injections of 12 mg of betamethasone (BMZ) 24 hours apart originated from preclinical experiments in the 1960s and has not been investigated in randomized clinical trials. These authors therefore designed a randomized trial for investigating whether a half dose of BMZ would be as effective as the standard full-dose regimen. The primary outcome was the need for exogenous surfactant within the first 48 hours of life. Secondary outcomes included the incidence and severity of respiratory disease, such as respiratory distress syndrome.This randomized, multicenter, double-blind placebo-controlled, noninferiority study was conducted in 37 perinatal centers in France. Pregnant women 18 years or older with singleton pregnancies at risk of delivery preterm (and already treated with dose 1 of antenatal BMZ before 32 weeks' gestation) were eligible to participate. Exclusion criteria included multiple pregnancy, having previously received full-dose antenatal corticosteroids, 4 cm or greater cervical dilation, cervical length of 20 mm or greater, fetal major malformations or chromosomal aberrations, or being unable to communicate fluently in French. Upon hospital admission after the first BMZ injection, women were provided information about the trial, and those who agreed were randomly assigned in a 1:1 ratio to receive either a saline placebo or the second intramuscular BMZ dose.A total of 3196 women participated, with 1597 in the half-dose group and 1599 in the full-dose group. In all, 30 fetuses were stillborn, 16 neonates were lost to follow-up, and 9 neonates died before evaluation, leaving 1567 neonates in the half-dose group and 1574 neonates in the full-dose group. In the intention-to-treat analysis, the primary outcome occurred in 313 (20%) of neonates in the half-dose group and 276 (17.5%) in the full-dose group (risk difference, 2.4%; 95% confidence interval [CI], 0.3–5.2); thus, noninferiority was not shown. The per-protocol analysis also did not show noninferiority (risk difference, 2.2%; 95% CI, −0.6 to 5.1). There were no differences in the rates of neonatal death, grade 3 to 4 intraventricular hemorrhage, stage ≥2 necrotizing enterocolitis, severe retinopathy of prematurity, or bronchopulmonary dysplasia. Between the 2 groups, all other secondary prematurity-associated outcomes were also similar.Strengths of the study included its large sample size and low loss-to-follow-up rate (0.5%), as well as consistent perinatal management approach through the Groupe de Recherche en Obstetrique et Gynecologie. However, the study also had limitations, such as the potential for the primary outcome to be considered a short-term surrogate only partially reflecting the overall severity of neonatal illness. The rate of the primary outcome observed in the study was also 2.5% lower than anticipated, which the authors attribute to the numbers of deliveries that occurred before 32 weeks' gestation and beyond 7 days following treatment. The number of births occurring within this window of time may limit the ability to demonstrate true differences between the 2 groups, meaning that the authors could not rule out the possibility of half-doses being inferior given higher preterm birth rates. In addition, long-term evaluation of the infants involved in the study via a follow-up evaluation at 5 years of age will be critical to determining the overall effect of BMZ dose reduction on neurological development.The authors concluded that this trial indicated the half-dose antenatal BMZ regimen did not meet criterion for noninferiority when compared with the currently recommended regimen in singleton pregnancies for preventing respiratory distress syndrome that requires exogenous intratracheal surfactant.

Published
2023
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38. Impact of parental separation or divorce on school performance in preterm children: A population-based study

Author

Nusinovici, Simon, Olliac, Bertrand, Flamant, Cyril, Müller, Jean-Baptiste, Olivier, Marion, Rouger, Valérie, Gascoin, Géraldine, Basset, Hélène, Bouvard, Charlotte, Roze, Jean-Christophe, Hanf, Matthieu, Ehrhardt, Harald, CIC Plurithématique de Nantes, Institut National de la Santé et de la Recherche Médicale (INSERM)-Ministère des Affaires sociales et de la Santé-Direction générale de l'offre de soins (DGOS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), CH Esquirol [Limoges] (CH Esquirol), Reseau Grandir Ensemble, Centre hospitalier universitaire de Nantes (CHU Nantes), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Centre Hospitalier Le Mans (CH Le Mans), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], and Grelier, Elisabeth

Subjects
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, education, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

International audience; The objective of this study was to quantify the possible decrease in school performance at five years of age in preterm children associated with parental separation or divorce, and to test whether this effect varies according to the child's age at the time of the separation. This study included 3,308 infants delivered at < 35 weeks of gestation born between 2003 and 2011 who were enrolled in the population-based LIFT cohort and who had an optimal neurodevelopmental outcome at two years of age. These infants were evaluated by their teachers to assess their abilities and behavior when they had reached five years of age, using the Global School Adaptation (GSA) questionnaire. The mean GSA score was 50.8 points. Parental separations (assessed as parents either living together or living separately) were associated with a decrease in school performance at five years of age, although this was only the case for children who exhibited difficulties at school (3.7 points, p < 0.01). A decrease in school performance only occurred when parental separations took place between 3 and 5 years after the child's birth. Parental separation was associated with a decrease in these children's levels of motivation, autonomy, and manual dexterity. This study indicates that preterm infants of parents who had separated are particularly at risk of a lower scholar performance.

Published
2018

41. Relative contributions of prenatal complications, perinatal characteristics, neonatal morbidities and socio-economic conditions of preterm infants on the occurrence of developmental disorders up to 7 years of age

Author

Müller, Jean-Baptiste, primary, Hanf, Matthieu, additional, Flamant, Cyril, additional, Olivier, Marion, additional, Rouger, Valérie, additional, Gascoin, Géraldine, additional, Basset, Hélène, additional, Rozé, Jean-Christophe, additional, and Nusinovici, Simon, additional

Published
2018
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42. Association between extremely preterm caesarean delivery and maternal depressive and anxious symptoms: a national population‐based cohort study.

Author

Blanc, J, Rességuier, N, Lorthe, E, Goffinet, F, Sentilhes, L, Auquier, P, Tosello, B, d'Ercole, C, Ancel, Pierre‐Yves, Arnaud, Catherine, Blanc, Julie, Boileau, Pascal, Debillon, Thierry, Delorme, Pierre, D'Ercole, Claude, Desplanches, Thomas, Diguisto, Caroline, Foix‐L'Hélias, Laurence, Garbi, Aurélie, and Gascoin, Géraldine

Abstract

Objective: To evaluate whether caesarean delivery before 26 weeks of gestation was associated with symptoms of depression and anxiety in mothers in comparison with deliveries between 26 and 34 weeks. Design: Prospective national population‐based EPIPAGE‐2 cohort study. Setting: 268 neonatology departments in France, March to December 2011. Population: Mothers who delivered between 22 and 34 weeks and whose self‐reported symptoms of depression (Center for Epidemiologic Studies Depression Scale: CES‐D) and anxiety (State‐Trait Anxiety Inventory: STAI) were assessed at the moment of neonatal discharge. Methods: The association of caesarean delivery before 26 weeks with severe symptoms of depression (CES‐D ≥16) and anxiety (STAI ≥45) was assessed by weighted and design‐based log‐linear regression model. Main outcome measures: Severe symptoms of depression and anxiety in mothers of preterm infants. Results: Among the 2270 women completing CES‐D and STAI questionnaires at the time of neonatal discharge, severe symptoms of depression occurred in 25 (65.8%) women having a caesarean before 26 weeks versus in 748 (50.6%) women having a caesarean after 26 weeks. Caesarean delivery before 26 weeks was associated with severe symptoms of depression compared with caesarean delivery after 26 weeks (adjusted relative risk [aRR] 1.42, 95% CI 1.12–1.81) adjusted to neonatal birthweight and severe neonatal morbidity among other factors. There was no evidence of an association between mode of delivery and symptoms of anxiety. Conclusions: Mothers having a caesarean delivery before 26 weeks' gestation are at high risk of symptoms of depression and may benefit from specific preventive care. Mothers having caesarean delivery before 26 weeks' gestation are at high risk of symptoms of depression. Mothers having caesarean delivery before 26 weeks' gestation are at high risk of symptoms of depression. [ABSTRACT FROM AUTHOR]

Published
2021
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43. The impact of chorionicity on pregnancy outcome and neurodevelopment at 2 years old among twins born preterm: the EPIPAGE-2 cohort study.

Author

Tosello, B, Garbi, A, Blanc, J, Lorthe, E, Foix‐L'Hélias, L, D'Ercole, C, Winer, N, Subtil, D, Goffinet, F, Kayem, G, Resseguier, N, Gire, C, Ancel, Pierre‐Yves, Arnaud, Catherine, Boileau, Pascal, Debillon, Thierry, Delorme, Pierre, Desplanches, Thomas, Diguisto, Caroline, and Gascoin, Géraldine

Subjects
PREGNANCY outcomes, HIGH-risk pregnancy, FETOFETAL transfusion, TWINS, INTENSIVE care units, COHORT analysis, PREMATURE infant diseases, AGE distribution, CHORION, SYMPTOMS, PLACENTA, LONGITUDINAL method, MULTIPLE pregnancy
Abstract

Objective: To compare the short- and mid-term outcomes of preterm twins by chorionicity of pregnancy.Design: Prospective nationwide population-based EPIPAGE-2 cohort study.Setting: 546 maternity units in France, between March and December 2011.Population: A total of 1700 twin neonates born between 24 and 34 weeks of gestation.Methods: The association of chorionicity with outcomes was analysed using multivariate regression models.Main Outcome Measures: First, survival at 2-year corrected age with or without neurosensory impairment, and second, perinatal, short-, and mid-term outcomes (survival at discharge, survival at discharge without severe morbidity) were described and compared by chorionicity.Results: In the EPIPAGE 2 cohort, 1700 preterm births were included (850 twin pregnancies). In all, 1220 (71.8%) were from dichorionic (DC) pregnancies and 480 from monochorionic (MC) pregnancies. MC pregnancies had three times more medical terminations than DC pregnancies (1.67 versus 0.51%, P < 0.001), whereas there were three times more stillbirths in MC than in DC pregnancies (10.09 versus 3.78%, P < 0.001). Both twins were alive at birth in 86.6% of DC pregnancies compared with 80.0% among MC pregnancies (P = 0.008). No significant difference according to chorionicity was found regarding neonatal deaths and morbidities. Likewise, for children born earlier than 32 weeks, the 2-year follow-up neurodevelopmental results were not significantly different between DC and MC twins.Conclusions: This study confirms that MC pregnancies have a higher risk of adverse outcomes. However, the outcomes among preterm twins admitted to neonatal intensive care units are similar irrespective of chorionicity.Tweetable Abstract: Monochorionicity is associated with adverse perinatal outcomes, but outcomes for preterm twins are comparable irrespective of their chorionicity. [ABSTRACT FROM AUTHOR]

Published
2021
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44. Propofol versus placebo (with rescue with ketamine) before less invasive surfactant administration: study protocol for a multicenter, double-blind, placebo controlled trial (PROLISA).

Author

Chevallier, Marie, Durrmeyer, Xavier, Ego, Anne, Debillon, Thierry, The PROLISA Study Group, Beuchee, Alain, Bourgoin, Laura, Desenfants, Aurélie, Durandy, Amélie, Flamant, Cyril, Gascoin, Géraldine, Ghostine, Ghida, Parra, Johanna, Ponthier, Laure, Roué, Jean-Michel, and PROLISA Study Group

Subjects
PROPOFOL, SURFACE active agents, POSTOPERATIVE nausea & vomiting, INTENSIVE care units, PROPOFOL infusion syndrome, NEONATAL intensive care, PREMEDICATION, INTRAVENOUS anesthesia
Abstract

Background: One major limitation for less invasive surfactant administration (LISA) is the difficulty in providing sedation before this procedure and the competitive risk of respiratory depression versus avoidance of intubation for most sedative or analgesic drugs used in this context. The objective of this study is to compare the need for mechanical ventilation within 72 h of life following premedication with propofol, versus placebo (rescue with ketamine), for the LISA procedure in preterm neonates born before 32 weeks gestational age (wGA).Methods: ProLISA is a phase III, non-inferiority, multicenter, double blind, randomized, placebo controlled trial designed according to the SPIRIT Statement. Neonates born before 32 wGA in 12 geographically dispersed Neonatal Intensive Care Units in France needing surfactant will be included from September 2019 to September 2022. A sample of 542 patients is needed. The neonate is randomized to the intervention (propofol) or control placebo group. Open label rescue treatment with ketamine is possible in both groups if FANS (Faceless Acute Neonatal pain Scale) is ≥6. To guide drug administration, FANS is scored before attempting laryngoscopy. Once an adequate score has been obtained, LISA is performed according to a standardized protocol. The primary outcome is the need for mechanical ventilation within 72 h of life. Secondary outcomes are tolerance of the procedure, pain evaluation, hemodynamic and neurologic parameters after the intervention, morbidities before discharge and neurodevelopmental assessment at 2 years of age.Discussion: This paper describes the first multicenter, double-blind, randomized, placebo-controlled trial on this topic and will provide crucial information to support implementation of the LISA procedure.Trial Registration: ClinicalTrials.gov: NCT04016246. Registered 06 June 2019, N°EUDRACT: 2018-002876-41. [ABSTRACT FROM AUTHOR]

Published
2020
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45. Clinical Practice Guidelines for Childbearing Female Candidates for Bariatric Surgery, Pregnancy, and Post-partum Management After Bariatric Surgery.

Author

Ciangura, Cécile, Coupaye, Muriel, Deruelle, Philippe, Gascoin, Géraldine, Calabrese, Daniela, Cosson, Emmanuel, Ducarme, Guillaume, Gaborit, Bénédicte, Lelièvre, Bénédicte, Mandelbrot, Laurent, Petrucciani, Niccolo, Quilliot, Didier, Ritz, Patrick, Robin, Geoffroy, Sallé, Agnès, Gugenheim, Jean, Nizard, Jacky, BARIA-MAT Group, Castera, Virginie, and Coutant, Régis

Subjects
POSTPARTUM contraception, BARIATRIC surgery, PREGNANCY, MATERNAL age, GESTATIONAL diabetes, GASTRIC banding
Abstract

Emerging evidence suggests that bariatric surgery improves pregnancy outcomes of women with obesity by reducing the rates of gestational diabetes, pregnancy-induced hypertension, and macrosomia. However, it is associated with an increased risk of a small-for-gestational-age fetus and prematurity. Based on the work of a multidisciplinary task force, we propose clinical practice recommendations for pregnancy management following bariatric surgery. They are derived from a comprehensive review of the literature, existing guidelines, and expert opinion covering the preferred type of surgery for women of childbearing age, timing between surgery and pregnancy, contraception, systematic nutritional support and management of nutritional deficiencies, screening and management of gestational diabetes, weight gain during pregnancy, gastric banding management, surgical emergencies, obstetrical management, and specific care in the postpartum period and for newborns. [ABSTRACT FROM AUTHOR]

Published
2019
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46. Study of mitochondrial function in placental insufficiency

Author

Lefebvre, Tiphaine, primary, Roche, Ombeline, additional, Seegers, Valérie, additional, Cherif, Majida, additional, Khiati, Salim, additional, Gueguen, Naïg, additional, Desquiret-Dumas, Valérie, additional, Geffroy, Guillaume, additional, Blanchet, Odile, additional, Reynier, Pascal, additional, Legendre, Guillaume, additional, Lenaers, Guy, additional, Procaccio, Vincent, additional, and Gascoin, Géraldine, additional

Published
2018
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47. Placental Multi-Omics Data-Mining in Intrauterine Growth Restriction

Author

Chabrun, Floris, primary, Huetz, Noémie, additional, Dieu, Xavier, additional, Rousseau, Guillaume, additional, Bouzillé, Guillaume, additional, Chao de la Barca, Juan Manuel, additional, Procaccio, Vincent, additional, Lenaers, Guy, additional, Blanchet, Odile, additional, Legendre, Guillaume, additional, Mirebeau-Prunier, Delphine, additional, Cuggia, Marc, additional, Guardiola, Philippe, additional, Reynier, Pascal, additional, and Gascoin, Géraldine, additional

Published
2018
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