26 results on '"Garzoli E"'
Search Results
2. Baseline staging in cutaneous malignant melanoma
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HAFNER, J., SCHMID, M. HESS, KEMPF, W., BURG, G., KüNZI, W., MEULI-SIMMEN, C., NEFF, P., MEYER, V., MIHIC, D., GARZOLI, E., JUNGIUS, K-P., SEIFERT, B., DUMMER, R., and STEINERT, H.
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- 2004
3. VALIDATION OF THE PROGNOSTIC MODEL PROPOSED BY “THE FRENCH STUDY GROUP ON CARCINOMAS OF UNKNOWN PRIMARY”
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Pinotti, G., Garzoli, E., Vallini, I., and Zanlorenzi, L.
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- 2003
4. Mammography, Sonography and MRI for Detection and Characterization of Invasive Lobular Carcinoma of the Breast
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Michael, M., primary, Garzoli, E., additional, and Reiner, C.S., additional
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- 2009
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5. Ultraschallgesteuerte Schneidbiopsien nicht palpabler Mammaläsionen: Korrelation mit den Ergebnissen der ultraschallgesteuerten Feinnadelpunktion
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Hilfiker, P.R., primary, Caduff, R., additional, Pok-Lundquist, J., additional, Garzoli, E., additional, Marincek, B., additional, and Kubik-Huch, R.A., additional
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- 2000
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6. Improved diagnostic accuracy in dynamic contrast enhanced MRI of the breast by combined quantitative and qualitative analysis.
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Liu, P F, primary, Debatin, J F, additional, Caduff, R F, additional, Kacl, G, additional, Garzoli, E, additional, and Krestin, G P, additional
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- 1998
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7. Clinical and Laboratory Investigations Baseline staging in cutaneous malignant melanoma.
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Hafner, J., Schmid, M. Hess, Kempf, W., Burg, G., Künzi, W., Meuli-Simmen, C., Neff, P., Meyer, V., Mihic, D., Garzoli, E., Jungius, K.-P., Seifert, B., Dummer, R., and Steinert, H.
- Subjects
MELANOMA ,POSITRON emission tomography ,RADIOGRAPHY ,MEDICAL imaging systems ,LYMPH nodes ,DERMATOLOGY - Abstract
Background Baseline staging in patients with primary cutaneous malignant melanoma (MM) is routine, but the diagnostic accuracy and the impact on clinical outcome are still unclear. Objectives To evaluate the sensitivity and specificity of baseline staging in the early detection of regional lymph node metastases or distant metastases in patients with MM. Methods One hundred consecutive patients with MM of Breslow's tumour thickness over 1·0 mm were enrolled. All patients had an extensive baseline staging including physical examination, ultrasound (US) of the abdomen and regional lymph nodes, chest X-ray, whole-body positron emission tomography (PET) and sentinel lymph node biopsy. The sensitivity and specificity of detection of macroscopic or microscopic metastases in the regional lymph nodes or at distant sites were calculated for each method. Results Sentinel lymph node biopsy was positive in 26 patients. US detected two of 26 histologically tumour-positive sentinel nodes (sensitivity 8%, specificity 88%) and PET two of 26 (sensitivity 8%; specificity 100%). There were three lymph node metastases with a diameter > 4 mm. All of them were found suspect at physical examination. Two of them were detectable with US, two with PET, and all were identified with either US or PET. Nine patients had suspect findings at distant sites, which were all false positive on further investigation (specificity of the combined staging procedures 91%). At 18 (6-37) months' follow-up, five of 26 (19%) patients with a positive sentinel node and four of 74 (5%) of patients with a negative sentinel node had recurrent or progressive disease. Conclusions The combination of physical examination and lymph node US detects the great majority of patients with macroscopic lymph node metastasis (approximately 3% of patients at baseline). Only 10% of patients who have a histologically tumour-positive sentinel node are macroscopically detectable. Altogether, approximately 25% of patients have a positive sentinel node biopsy, among 90% microscopic. The value of whole body staging at baseline remains limited, since distant metastases can hardly ever be detected. The survival benefit of baseline staging and surveillance in patients with cutaneous MM remains to be established by comparative prospective trials. [ABSTRACT FROM AUTHOR]
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- 2004
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8. La teoría del preconsciente y la investigación sistemática del discurso en psicoanálisis.
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Maldavsky, D., Bodni, O., Buceta, C., Cusien, I., Garzoli, E., de Widder, F. Lambersky, Roitman, C. R., de Stanley, C. Tate, Tarrab, E., and de Manson, M. Truscello
- Published
- 2004
9. Symptomatic COVID-19 in advanced-cancer patients treated with immune-checkpoint inhibitors: prospective analysis from a multicentre observational trial by FICOG.
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Bersanelli M, Giannarelli D, De Giorgi U, Pignata S, Di Maio M, Verzoni E, Clemente A, Guadalupi V, Signorelli D, Tiseo M, Giusti R, Filetti M, Di Napoli M, Calvetti L, Cappetta A, Ermacora P, Zara D, Barbieri F, Baldessari C, Scotti V, Mazzoni F, Veccia A, Guglielmini PF, Maruzzo M, Rossi E, Grossi F, Casadei C, Cortellini A, Verderame F, Montesarchio V, Rizzo M, Mencoboni M, Zustovich F, Fratino L, Cinieri S, Negrini G, Banzi M, Sorarù M, Zucali PA, Lacidogna G, Russo A, Battelli N, Fornarini G, Mucciarini C, Bracarda S, Bonetti A, Pezzuolo D, Longo L, Sartori D, Iannopollo M, Cavanna L, Meriggi F, Tassinari D, Corbo C, Gernone A, Prati V, Carnio S, Giordano P, Dicorato AM, Verusio C, Atzori F, Carrozza F, Gori S, Castro A, Pilotto S, Vaccaro V, Garzoli E, Di Costanzo F, Maiello E, Labianca R, Pinto C, Tognetto M, and Buti S
- Abstract
Background: This prospective, multicentre, observational INVIDIa-2 study is investigating the clinical efficacy of influenza vaccination in advanced-cancer patients receiving immune-checkpoint inhibitors (ICIs), enrolled in 82 Italian centres, from October 2019 to January 2020. The primary endpoint was the incidence of influenza-like illness (ILI) until 30 April 2020. All the ILI episodes, laboratory tests, complications, hospitalizations and pneumonitis were recorded. Therefore, the study prospectively recorded all the COVID-19 ILI events., Patients and Methods: Patients were included in this non-prespecified COVID-19 analysis, if alive on 31 January 2020, when the Italian government declared the national emergency. The prevalence of confirmed COVID-19 cases was detected as ILI episode with laboratory confirmation of SARS-CoV-2. Cases with clinical-radiological diagnosis of COVID-19 (COVID-like ILIs), were also reported., Results: Out of 1257 enrolled patients, 955 matched the inclusion criteria for this unplanned analysis. From 31 January to 30 April 2020, 66 patients had ILI: 9 of 955 cases were confirmed COVID-19 ILIs, with prevalence of 0.9% [95% confidence interval (CI): 0.3-2.4], a hospitalization rate of 100% and a mortality rate of 77.8%. Including 5 COVID-like ILIs, the overall COVID-19 prevalence was 1.5% (95% CI: 0.5-3.1), with 100% hospitalization and 64% mortality. The presence of elderly, males and comorbidities was significantly higher among patients vaccinated against influenza versus unvaccinated ( p = 0.009, p < 0.0001, p < 0.0001). Overall COVID-19 prevalence was 1.2% for vaccinated (six of 482 cases, all confirmed) and 1.7% for unvaccinated (8 of 473, 3 confirmed COVID-19 and 5 COVID-like), p = 0.52. The difference remained non-significant, considering confirmed COVID-19 only ( p = 0.33)., Conclusion: COVID-19 has a meaningful clinical impact on the cancer-patient population receiving ICIs, with high prevalence, hospitalization and an alarming mortality rate among symptomatic cases. Influenza vaccination does not protect from SARS-CoV-2 infection., Competing Interests: Conflict of interest statement: The Federation of Italian Cooperative Oncology Groups (FICOG) received funding for the present study by Seqirus and Roche S.p.A.; the Federation also received funding during the conduct of the present study by Astra Zeneca, Bristol Myers Squibb (BMS), Sanofi. Melissa Bersanelli received funding for the present study by Seqirus and Roche S.p.A. (FICOG as Institution, no personal fees). She also received, outside the present work, research funding from Pfizer and Novartis (Institution), honoraria as speaker at scientific events (personal fees) by Astra Zeneca, Bristol Myers Squibb (BMS), Novartis and Pfizer; as consultant for advisory role (personal fees) by Novartis, BMS and Pfizer. Ugo De Giorgi received honoraria from AstraZeneca, Roche, MSD, Pfizer, GSK, Clovis, Incyte and research funding from Roche, AstraZeneca, MSD, Pfizer. Dr Di Maio reports personal fees from Bristol Myers Squibb, personal fees from Merck Sharp & Dohme, personal fees from AstraZeneca, personal fees from Janssen, personal fees from Astellas, personal fees from Pfizer, personal fees from Eisai, personal fees from Takeda, grants from Tesaro GSK, outside the submitted work. Sebastiano Buti received honoraria as speaker at scientific events and advisory role by BMS, Pfizer; MSD, Ipsen, Roche S.p.A., Eli Lilly, AstraZeneca and Novartis; he also received research funding from Novartis. Marcello Tiseo received honoraria (personal fees) by MSD, BMS, Boehringer (BI), Takeda, AstraZeneca, and research funding by AstraZeneca (Institution). Vieri Scotti participated, with personal fees, to advisory boards and speaker’s bureaus for Roche S.p.A. Dr Cortellini reports grants from AstraZeneca, grants from MSD, grants from BMS, grants from Roche, during the conduct of the study; grants from AstraZeneca, grants from MSD, grants from BMS, grants from Roche, grants from Novartis, outside the submitted work. Saverio Cinieri declared international board for Eli Lilly international. Paolo Andrea Zucali acts in a consultant or advisory role for Sanofi, BMS, Pfizer, MSD, Astellas, Janssen, Ipsen, Novartis, all outside the scope of work. Sergio Bracarda declares to have acted as advisory board member (uncompensated) for: Janssen, Astellas, Pfizer, MSD, BMS, Merck, AstraZeneca, AAA, Ipsen, Bayer, Roche/Genentech. Francesco Carozza declared personal fees from Janssen. Sara Pilotto reports personal fees from AstraZeneca, Eli Lilly, Boehringer Ingelheim, Merk & Co, Roche, outside the submitted work. All remaining authors have declared no conflicts of interest., (© The Author(s), 2020.)
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- 2020
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10. Feeding dysfunctions and failure to thrive in neonates with congenital heart diseases.
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Mangili G, Garzoli E, and Sadou Y
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- Breast Feeding, Enteral Nutrition methods, Enterocolitis, Necrotizing epidemiology, Enterocolitis, Necrotizing etiology, Enterocolitis, Necrotizing prevention & control, Failure to Thrive etiology, Failure to Thrive therapy, Heart Defects, Congenital physiopathology, Humans, Infant, Newborn, Infant, Premature, Nutritional Requirements, Failure to Thrive epidemiology, Heart Defects, Congenital complications, Nutritional Support methods
- Abstract
Congenital heart disease (CHD) is the most common neonatal congenital malformation. The variety and severity of clinical presentation depend on the cardiac structures involved and their functional impact. The management of newborns with CHD requires a multidisciplinary approach, in which the nutritional aspect plays an important role. An adequate caloric intake during either preand post-surgical period, in fact, improves the outcome of these patients. In addition, the failure to thrive of these children in childhood has been related to long-term cognitive delay (attention deficit disorders, aggressive behaviour and poor social and emotional development). To date, there is a lack of standardized feeding protocols and caloric goals about how to feed neonates with CHD, and current practice varies widely between centres. The latest American Society for Parenteral and Enteral Nutrition guidelines reiterate the importance of proteins, and recommend early start of enteral nutrition, also in the most severe heart diseases, such as univentricular forms. Necrotizing enterocolitis (NEC), the most frequent and feared complication of early feeding of these newborns, often represents an obstacle in spreading this practice. Furthermore, as demonstrated in premature infants, breastfeeding seems to reduce the incidence of NEC. That is why breastfeeding must be encouraged, even if it can be difficult for these mothers due to delivery complications, associated with infant disease. In addition, eating difficulties may persist even after discharge, because these patients require nutritional support through nasogastric tubes or percutaneous endoscopic gastrostomies.
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- 2018
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11. Feeding of preterm infants and fortification of breast milk.
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Mangili G and Garzoli E
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- Enteral Nutrition methods, Female, Food, Fortified, Humans, Infant Nutritional Physiological Phenomena, Infant, Newborn, Infant, Premature, Infant, Very Low Birth Weight, Breast Feeding, Infant Formula, Milk, Human
- Abstract
The administration of the adequate amount of nutrients helps to improve a correct short-term linear growth and long-term neurocognitive development. To reduce the extra-uterine growth delay in very low birth weight infants (VLBW) the best strategy of nutrition (parenteral or enteral) should be established rapidly, since the first day of life. In preterm infants, nutrition can be administered parenterally and enterally. Prematurity is the most frequent indication for parenteral nutritional support due to intestinal functional immune deficiency, deficiency of digestive enzymatic systems and reduced nutritional reserve of these infants. In terms of enteral nutrition, breast milk is the first choice. In case of preterm and VLBW infants, fortifiers are used to overcome breast milk's protein and mineral deficiencies. When breast milk is not available, specific infant formula is the alternative.
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- 2017
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12. Diagnostic accuracy and prognostic value of the CD64 index in very low birth weight neonates as a marker of early-onset sepsis.
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Motta M, Zini A, Regazzoli A, Garzoli E, Chirico G, Caimi L, and Calarco M
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- Biomarkers blood, Female, Gestational Age, Humans, Infant, Extremely Low Birth Weight blood, Infant, Newborn, Male, Premature Birth, Prognosis, Prospective Studies, ROC Curve, Infant, Very Low Birth Weight blood, Receptors, IgG blood, Sepsis blood
- Abstract
Objective: To assess the diagnostic and prognostic utility of CD64 expression as a marker of early-onset sepsis (EOS) in very low birth weight (VLBW) neonates., Methods: Neutrophil CD64 expression (CD64 index) was assessed in 129 VLBW neonates within 72 h after birth. The accuracy of the CD64 index in predicting EOS was determined by receiver operating characteristic curve analysis. The relationship between the expression of the CD64 index and neonatal outcomes was evaluated by multivariate analysis., Results: The highest performance of the CD64 index was achieved at 24 h after birth; accuracy, sensitivity, and negative predictive values were 0.85, 0.89, and 0.99, respectively, with a cut-off value of 2.4. The increased expression of CD64 index was significantly associated with subsequent infections (relative risk 1.54; 95% confidence interval 1.02-2.33)., Conclusions: The CD64 index could be used as a reliable marker of EOS in VLBW neonates and it is an independent risk factor for late-onset infections.
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- 2014
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13. Management of neoplastic pericardial effusions.
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Cozzi S, Montanara S, Luraschi A, Fedeli P, Buscaglia P, Amodei V, Fossati O, Gioria A, Garzoli E, and Ferrari G
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- Adult, Aged, Breast Neoplasms complications, Cardiac Tamponade mortality, Female, Humans, Lung Neoplasms complications, Lymphoma, B-Cell complications, Male, Middle Aged, Pericardial Effusion mortality, Survival Analysis, Treatment Outcome, Cardiac Tamponade etiology, Cardiac Tamponade therapy, Pericardial Effusion etiology, Pericardial Effusion therapy, Pericardiocentesis
- Abstract
Aims and Background: Malignant pericardial effusion and cardiac tamponade are known complications of many advanced malignancies such as breast cancer, lung cancer, lymphomas and leukemias. Overall survival is low, due to other metastatic localizations. The present study evaluated the clinical outcome and prognosis in patients with advanced cancer with pericardial effusion., Methods: We studied 7 patients, 4 men and 3 women, with malignant pericardial effusion, affected by breast cancer (2 patients), lung cancer (adenocarcinoma in 3 patients, microcytoma in 1 patient), and B-cell non-Hodgkin lymphoma (1 patient). All patients underwent pericardiocentesis; 3 patients underwent an instillation of thiotepa., Results: One terminal patient treated with pericardiocentesis died after only a few hours. All the remaining patients experienced immediate symptomatic improvement and no operative complications. At the end of the study period, 2 patients were alive at 59 and 33 months, respectively, and 4 died of disease progression at 1 to 32 months (mean, 10.5)., Conclusions: Pericardiocentesis is an active necessary approach, and intrapericardial treatment with thiotepa was able to reduce pericardial effusion and to prevent its reaccumulation. The standard treatment of malignant effusion and cardiac tamponade has not yet been defined. Physicians should consider the status and the prognosis of each case.
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- 2010
14. The Effects of helium/oxygen mixture (heliox) before and after extubation in long-term mechanically ventilated very low birth weight infants.
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Migliori C, Gancia P, Garzoli E, Spinoni V, and Chirico G
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- Blood Gas Monitoring, Transcutaneous, Continuous Positive Airway Pressure, Female, Humans, Infant, Newborn, Long-Term Care, Lung Volume Measurements, Male, Respiratory Distress Syndrome, Newborn physiopathology, Helium administration & dosage, Infant, Very Low Birth Weight, Oxygen administration & dosage, Pulmonary Gas Exchange physiology, Respiratory Distress Syndrome, Newborn therapy, Respiratory Mechanics physiology, Ventilator Weaning
- Abstract
Objectives: Our goal was to evaluate the effects of a helium/oxygen mixture (heliox) on pulmonary mechanics and gas exchange in preterm infants during both conventional and noninvasive ventilation., Patients and Methods: Ten preterm infants, ventilated from birth, were enrolled. Resistive work of breathing, pulmonary compliance, static compliance, respiratory rate, minute ventilation, ventilatory support, and gas exchange were measured before and during treatment. One hour after heliox therapy, subjects who showed a decrease of peak inspiratory pressure of >20% of the initial value were extubated and shifted to nasal bilevel positive airway pressure with heliox for the following 3 hours. Pulmonary mechanics and ventilatory parameters were measured during air/oxygen ventilation and again 10 minutes and 1 hour after starting heliox. Transcutaneous pressure of O(2) and CO(2), oxygen saturation, and respiratory rate were recorded continuously. Arterial blood gases were measured immediately before and 1 hour after initiating bilevel positive airway pressure. To maintain oxygen saturation at >92% during the bilevel positive airway pressure phase, the mean fraction of inspired oxygen was increased from 0.34 to 0.36., Results: Mean peak inspiratory pressure decreased from 21.4 to 17.4 cmH(2)O, work of breathing decreased from 0.46 to 0.22 joule/L, and transcutaneous pressure of CO(2) decreased from 52.3 to 49.1 mmHg. Mean transcutaneous pressure of O(2) improved from 42.8 to 46.7 mmHg, and minute ventilation improved from 332 to 478 mL/kg per minute. No significant differences were observed in mean airway pressure, respiratory rate, oxygen saturation, pulmonary compliance, and static compliance. Eight infants were extubated. One of them needed to be reintubated after 5 hours., Conclusions: Our data show that mechanical ventilation with heliox reduces resistive work of breathing and ventilatory support requirements and improves gas exchange in preterm infants.
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- 2009
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15. Mammography, sonography and MRI for detection and characterization of invasive lobular carcinoma of the breast.
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Michael M, Garzoli E, and Reiner CS
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- Female, Humans, Magnetic Resonance Imaging, Mammography, Middle Aged, Neoplasm Staging, Ultrasonography, Mammary, Breast Neoplasms diagnosis, Carcinoma, Lobular diagnosis
- Abstract
Imaging of invasive lobular carcinoma (ILC) is more challenging than other types of breast cancer because of its spider web like growth pattern. Mammography has a relevant number of false negative exams, especially in dense breasts. Mammographic appearance of ILC is often subtle. Distinct mass like aspects are absent more often when compared with other types of breast cancer, and lesions are frequently only mildly opaque. Microcalcifications are uncommon. The addition of an ultrasound exam can improve rates of detection and diagnosis of ILC, but even when combining modalities ILC can be missed. If clinical signs are suspicious, magnetic resonance imaging (MRI) can help to detect ILC. MRI should also be considered in preoperative staging if treatment with breast conservation is favoured, particularly to assess maximal tumor dimensions. Mammographic findings do not correlate well with pathological tumor size. Additional tumor sites detected by MRI only should be validated cautiously, and guidelines established for multicentricity detected by mammography should not be used in the same way.
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- 2008
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16. Evaluation of temporal windows for coronary artery bypass graft imaging with 64-slice CT.
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Desbiolles L, Leschka S, Plass A, Scheffel H, Husmann L, Gaemperli O, Garzoli E, Marincek B, Kaufmann PA, and Alkadhi H
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- Aged, Female, Humans, Male, Middle Aged, Observer Variation, Reproducibility of Results, Time Factors, Coronary Angiography methods, Coronary Artery Bypass methods, Coronary Artery Disease diagnosis, Coronary Artery Disease therapy, Image Processing, Computer-Assisted methods, Tomography, X-Ray Computed methods
- Abstract
Temporal windows providing the best image quality of different segments and types of coronary artery bypass grafts (CABGs) with 64-slice computed tomography (CT) were evaluated in an experimental set-up. Sixty-four-slice CT with a rotation time of 330 ms was performed in 25 patients (four female; mean age 59.9 years). A total of 84 CABGs (62 individual and 22 sequential grafts) were evaluated, including 28 internal mammary artery (33.3%), one radial artery with sequential grafting (2.4%), and 54 saphenous vein grafts (64.3%). Ten data sets were reconstructed in 10% increments of the RR-interval. Each graft was separated into segments (proximal and distal anastomosis, and body), and CABG types were grouped according to target arteries. Two readers independently assessed image quality of each CABG segment in each temporal window. Diagnostic image quality was found with good inter-observer agreement (kappa=0.62) in 98.5% (202/205) of all graft segments. Image quality was significantly better for saphenous vein grafts versus arterial grafts (P<0.001) and for distal anastomosis to the right coronary compared with other target coronary arteries (P<0.05). Overall, best image quality was found at 60%. Image quality of proximal segments did not significantly vary with the temporal window, whereas for all other segments image quality was significantly better at 60% compared with other temporal windows (P<0.05). Sixty-four-slice CT provides best image quality of various segments and types of CABG at 60% of the RR-interval.
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- 2007
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17. Accuracy of 64-slice computed tomography for the preoperative detection of coronary artery disease in patients with chronic aortic regurgitation.
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Scheffel H, Leschka S, Plass A, Vachenauer R, Gaemperli O, Garzoli E, Genoni M, Marincek B, Kaufmann P, and Alkadhi H
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- Adult, Aged, Aged, 80 and over, Aortic Valve Insufficiency diagnostic imaging, Chronic Disease, Coronary Angiography, Coronary Disease complications, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prognosis, Reproducibility of Results, Retrospective Studies, Severity of Illness Index, Aortic Valve Insufficiency complications, Coronary Disease diagnostic imaging, Heart Valve Prosthesis Implantation, Preoperative Care methods, Tomography, X-Ray Computed methods
- Abstract
We studied the diagnostic accuracy of 64-slice computed tomography for the diagnosis of significant coronary artery disease (CAD) compared with conventional coronary angiography (CA) in patients with chronic aortic regurgitation (AR) referred for elective aortic valve surgery. Fifty consecutive patients with chronic AR (38 men, mean age 54 +/- 14 years) scheduled for valve surgery underwent 64-slice computed tomographic (CT) coronary angiography and CA. Significant stenosis was defined as a luminal diameter decrease >50%. Mean heart rate during CT scanning was 65.5 +/- 7.4 beats/min. Mean Agatston score was 136 +/- 278 (range 0 to 1207); prevalence of significant CAD in the study population was 26% (13 of 50 patients). Thirteen of 742 segments (1.8%) in 3 patients were considered nondiagnostic with computed tomography because of motion artifacts (n = 9) or calcium (n = 4). In a patient-based analysis taking nonevaluative segments as falsely positive, sensitivity, specificity, and positive and negative predictive values of computed tomography were 100%, 95%, 87%, and 100%, respectively. Preoperative CA could have been avoided in 70% of patients (35 of 50), CA would have been performed to confirm the CT diagnosis in 26% (13 of 50), and unnecessary CA would have been performed in 4% (2 of 50) on the basis of false-positive CT ratings. In conclusion, 64-slice CT coronary angiography provides high diagnostic accuracy for diagnosing significant CAD in patients with chronic AR and may be used as a filter test before valve surgery to decide whether CA should be performed.
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- 2007
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18. Aminophylline treatment of refractory bronchospasm in mechanically ventilated neonates: case report.
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Migliori C, Garzoli E, Spinoni V, and Chirico G
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- Blood Pressure, Female, Gestational Age, Heart Rate, Humans, Infant, Newborn, Infant, Premature, Male, Oximetry, Oxygen metabolism, Respiration, Artificial methods, Respiratory Insufficiency drug therapy, Aminophylline therapeutic use, Bronchial Spasm drug therapy, Bronchodilator Agents therapeutic use, Respiration, Artificial adverse effects
- Abstract
Background: The aim was to determine the effectiveness of continuous aminophylline infusion on refractory bronchospasm in long-term mechanically ventilated neonates., Case Report: Presented are seven newborns with gestational ages from 24 to 38 weeks and mean age at treatment of 29.7 days. All were mechanically ventilated from birth because of respiratory distress syndrome. Bronchospasm was diagnosed by wheezing, worsening of gas exchange, lengthening of expiratory time, and the need to modify the peak inspiratory pressure (PIP) to maintain the tidal volume. All patients had received conventional bronchodilator treatment for more than 24 hours before aminophylline treatment, without significant response. After discontinuation of previous bronchodilator drugs, an intravenous 6 mg/kg aminophylline bolus was administered over 20 minutes, followed by continuous infusions of 0.7 mg/kg/h for 12 hours and 0.35 mg/kg/h during the next 12 hours. Altogether, the treatment was carried out for 24 hours. Pulse-oximetry saturation (SpO(2)), transcutaneous pO(2)/pCO(2) (TcPO(2)/PCO(2)), heart rate, blood pressure, mean airway pressure (MAP), and fraction of inspired oxygen (FiO(2)) were recorded before and after the treatment. The SpO(2) (p<0.005) and TcPO(2) (p<0.002) increased significantly, while significant reductions in TcPCO(2) (p<0.00008) and FiO(2) (p<0.03) were observed. No signs of toxicity or significant differences in heart rate or blood pressure were reported. Mean serum aminophylline concentration resulted in therapeutic levels at both 12 and 24 hours., Conclusions: It is suggested that continuous infusion of aminophylline is well tolerated and may prove useful in improving the gas exchange in long-term mechanically ventilated neonates with refractory bronchospasm.
- Published
- 2007
19. [Umbilical acid-base status of term infants: correlation with delivery mode].
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Garzoli E, Monteleone M, Migliori C, and Abrami F
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- Humans, Infant, Newborn, Acid-Base Equilibrium, Delivery, Obstetric, Fetal Blood chemistry
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Objective: To determine possible relations between Apgar score, umbilical artery haemogasanalysis and delivery mode., Methods: 948 babies were considered; preterm infants and charts with incomplete data were excluded. 762 newborns and their respective umbilical artery blood gas parameters at delivery were evaluated. The collected Data were related to mode of delivery: vaginal with and without analgesia, elective caesarean section (CS), CS after labour, emergency CS for non reassuring trace., Results: Mean pH (+/- DS) was 7.26 (+/- 0.08). The comparison vaginal delivery vs. CS was statistically significant (p < 0.0001). Analyzing the CS only, the babies born by emergency CS for non reassuring trace had pH statistically lower (ANOVA p < 0.004) and, in the latter group, there was a statistically difference between Italian newborns and those from other ethnicities (p < 0.02). No difference were found on Apgar score, excluding babies by vaginal delivery with analgesia that showed lower scores both at 1 (p < 0.02) and 5 (p < 0.002) minutes versus newborns without analgesia., Conclusions: Normal labour causes frequently a mild degree of acidosis, but it is not always related to neonatal asphyxia. The differences found between different delivery modes are, probably, the expression of causes related to the obstetric choice. That is also remarked by the statistically difference found in emergency CS for non reassuring trace in Italian population and in other ethnicities, showing a probably different cultural level, mainly about the "obstetric emergency" poorly understood by the pregnant. In vaginal deliveries the analgesia does not modify the neonatal metabolism, but can be a reason of delayed adaptation of extrauterine life.
- Published
- 2007
20. Images in clinical medicine. Calcified filariasis of the breasts.
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Alkadhi H and Garzoli E
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- Adult, Calcinosis etiology, Female, Filariasis complications, Humans, Mammography, Breast Diseases diagnostic imaging, Calcinosis diagnostic imaging, Filariasis diagnostic imaging
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- 2005
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21. Axillary cavernous lymphangioma in pregnancy and puerperium.
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Quack Loetscher KC, Jandali AR, Garzoli E, Pok J, and Beinder E
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- Adult, Axilla, Female, Humans, Lymphangioma diagnostic imaging, Lymphangioma therapy, Postpartum Period, Pregnancy, Pregnancy Complications, Neoplastic diagnostic imaging, Pregnancy Complications, Neoplastic therapy, Ultrasonography, Lymphangioma pathology, Pregnancy Complications, Neoplastic pathology
- Abstract
Background: Cavernous lymphangioma is a form of benign congenital abnormality grouped under lymphatic malformations, which can clinically manifest as a cystic tumor. Common areas are the neck and axillary region. Most cases are diagnosed in children under the age of 2, and occasionally the diagnosis is made in utero., Case: We present the case of a 29-year-old primigravid woman with an axillary cavernous lymphangioma which rapidly increased in size during pregnancy, and describe the treatment plan in this unusual situation., Conclusion: The treatment of a large lymphangioma during pregnancy has to be well planned, considering the welfare of the mother and baby. Most of the current therapies have never been tested in pregnant or lactating women. We discuss the possible pathomechanisms for the growth of lymphangioma during pregnancy with the overproduction of cytokines such as vascular endothelial growth factor., (Copyright (c) 2005 S. Karger AG, Basel.)
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- 2005
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22. [Differential diagnosis of benign and malignant mammary lesions with special regard to the BI-RADS((R)) classification system in mammography].
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Boehm T, Garzoli E, and Marincek B
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- Breast pathology, Breast Neoplasms classification, Breast Neoplasms pathology, Calcinosis classification, Calcinosis diagnostic imaging, Calcinosis pathology, Diagnosis, Differential, Documentation standards, Female, Fibrocystic Breast Disease classification, Fibrocystic Breast Disease pathology, Humans, Terminology as Topic, Breast Neoplasms diagnostic imaging, Fibrocystic Breast Disease diagnostic imaging, Mammography standards, Mass Screening standards, Quality Assurance, Health Care standards, Radiology Information Systems standards
- Abstract
Mammography is the imaging method of choice for the diagnostic workup of breast tumors in screening programs as well as in symptomatic patients. Quality assurance is one of the main prerequisites for a successful performance in both fields. Quality assurance on the technical and film processing level can be easily achieved compared to reporting and outcome monitoring on the level of the physician performing mammography. This is especially due to the lack of standards of the written reports. This article reviews the Breast Imaging Reporting and Data System (BI-RADS((R))) developed and commercialized by the American College of Radiology, contains several examples of lesion classification and discusses the significance of the BI-RADS((R)) approach.
- Published
- 2002
- Full Text
- View/download PDF
23. [Penile metastasis of carcinoma of the urinary bladder].
- Author
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Wolfensberger UE, Bagot A, Hailemariam S, Garzoli E, and Kubik-Huch RA
- Subjects
- Aged, Carcinoma, Transitional Cell diagnosis, Humans, Image Enhancement, Male, Penile Neoplasms diagnosis, Penis pathology, Carcinoma, Transitional Cell secondary, Magnetic Resonance Imaging, Penile Neoplasms secondary, Tomography, X-Ray Computed, Urinary Bladder Neoplasms diagnosis
- Published
- 2001
24. Abdominal pain in children: a case of acalculous cholecystitis.
- Author
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Trada M, Garzoli E, Falzoni PU, De Franco S, Sacco F, Aguzzi A, and Bona G
- Subjects
- Child, Preschool, Humans, Male, Abdominal Pain etiology, Cholecystitis complications
- Abstract
Acalculous cholecystitis is a rare disease in children. Most cases are associated with systemic infections or with autoimmune pathologies, but it may also occur without predisposing factors. A case observed in an otherwise healthy child is reported.
- Published
- 2000
25. [Ultrasound-guided biopsy of non-palpable breast lesions: correlation with the results of fine-needle aspiration biopsy].
- Author
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Hilfiker PR, Caduff R, Pok-Lundquist J, Garzoli E, Marincek B, and Kubik-Huch RA
- Subjects
- Adult, Aged, Breast Diseases diagnosis, Breast Diseases pathology, Breast Neoplasms diagnosis, Carcinoma, Ductal, Breast diagnosis, Carcinoma, Ductal, Breast pathology, Diagnosis, Differential, Female, Fibroadenoma diagnosis, Fibroadenoma pathology, Fibrocystic Breast Disease diagnosis, Fibrocystic Breast Disease pathology, Humans, Middle Aged, Biopsy methods, Biopsy, Needle, Breast pathology, Breast Neoplasms pathology, Ultrasonography, Mammary
- Abstract
Purpose: The purpose of this study was the clinical evaluation of ultrasound-guided biopsy in comparison with ultrasound-guided fine-needle aspiration biopsy of identical, non-palpable breast lesions., Materials and Methods: From August 1997 until July 1998, 73 ultrasound-guided biopsies were performed in 66 patients with non-palpable lesions of the breast. In 18 patients (age 33-77 years) with 20 non-palpable lesions, fine-needle aspiration biopsy (20-G needle) and biopsy (18-G biopsy needle) were performed on a single occasion. This was the patient selection of our retrospective study., Results: One malignant neoplasm was found among the 20 biopsied lesions, while the remaining 19 lesions were of a benign nature. In 20% of the cases, the material obtained by fine-needle biopsy was not sufficient for a cytologic diagnosis, while biopsy allowed a diagnosis in 19/20 cases. No complications were observed., Conclusions: Ultrasound-guided biopsy using an 18-G needle is a suitable method for the evaluation of non-palpable lesions that are only visible on ultrasound. It represents an attractive alternative to fine-needle aspiration in the absence of experienced cytologic diagnosticians.
- Published
- 2000
- Full Text
- View/download PDF
26. [Sepsis caused by Haemophilus influenzae type B with septic arthritis in an infant].
- Author
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Bona G, Cadario F, Benevenuta E, Sacco F, Garzoli E, and Passaro R
- Subjects
- Humans, Infant, Male, Arthritis, Infectious microbiology, Haemophilus Infections microbiology, Haemophilus influenzae type b isolation & purification
- Abstract
Septic arthritis is a serious pyogenic infection that may lead to permanent orthopedic sequelae. Infants represent the most of the cases. It usually develops as a result of bacterial seeding into the capillary-rich synovium in the course of a bacteremic episode. Etiology changes according to different ages; in children after the neonatal period but younger than 24 months, Haemophilus influenzae is the most frequent causative organism. A case of sepsis due to Haemophilus influenzae type b (Hib) with septic arthritis in a patient 3 months old, is reported. The child was admitted to the hospital with a very high temperature (39 degrees C) for five days. His right wrist and ankle appeared swelling and hyperemic. He was affected by congenital cardiopathy from birth. He was not immunizated against Hib. The blood colture was positive for Hib. The leukocyte count was 21,400 cell/mm3 with 55% of polymorphonuclear cells. During the second day of recovery, the patient was transfused, because of the very low value of hemoglobin (5.2 g/dl). The child was treated with netilmycina and ceftriaxone for 15 days. The temperature fell in two days. The articular pathology resolved in nearly ten days. The case reported confirms the importance of septic arthritis as a pathology that necessarily requires an early diagnosis and treatment. The Haemophilus influenzae vaccine, is recommended especially in immunocompromised or cardiopathic subjects and before the age of 2 years.
- Published
- 1998
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