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186 results on '"Garrigue, Delphine"'

2. Ferric derisomaltose and tranexamic acid, combined or alone, for reducing blood transfusion in patients with hip fracture (the HiFIT trial): a multicentre, 2 × 2 factorial, randomised, double-blind, controlled trial

Author

Bouhours, Guillaume, Lasocki, Sigismond, Lebail, Adeline, Léger, Maxime, Parot-Schinkel, Elsa, Rineau, Emmanuel, Rony, Louis, Vielle, Bruno, Capdevilla, Xavier, Loupec, Thibault, Mounet, Benjamin, Swisser, Fabien, Danguy des Deserts, Marc, Cinotti, Raphael, Grillot, Nicolas, Asehnoune, Karim, Roquilly, Antoine, Beloeil, Hélène, Lahlou-Casulli, Maria, Collange, Vincent, Parent, Sébastien, Delannoy, Bertrand, Desebbe, Olivier, Duchalais, Alexis, Drugeon, Bertrand, Guenezan, Jeremy, Bouzat, Pierre, Drevet, Sabine, Gavazzi, Gaetan, Greze, Jules, Bijok, Benjamin, Garrigue, Delphine, David, Jean-Stéphane, and Capdevila, Xavier

Published
2023
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3. Early hyperoxemia is associated with lower adjusted mortality after severe trauma: results from a French registry

Author

Baekgaard, Josefine S, Abback, Paer-Selim, Boubaya, Marouane, Moyer, Jean-Denis, Garrigue, Delphine, Raux, Mathieu, Champigneulle, Benoit, Dubreuil, Guillaume, Pottecher, Julien, Laitselart, Philippe, Laloum, Fleur, Bloch-Queyrat, Coralie, Adnet, Frédéric, and Paugam-Burtz, Catherine

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Traumatic Head and Spine Injury, Physical Injury - Accidents and Adverse Effects, Brain Disorders, Cardiovascular, Clinical Research, Traumatic Brain Injury (TBI), Injuries and accidents, Good Health and Well Being, Adolescent, Adult, Aged, Aged, 80 and over, Female, France, Humans, Hyperoxia, Logistic Models, Male, Middle Aged, Mortality, Protective Factors, Registries, Wounds and Injuries, Hyperoxemia, Trauma, Critical care, Oxygen, Traumabase® Study Group, Medical and Health Sciences, Emergency & Critical Care Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundHyperoxemia has been associated with increased mortality in critically ill patients, but little is known about its effect in trauma patients. The objective of this study was to assess the association between early hyperoxemia and in-hospital mortality after severe trauma. We hypothesized that a PaO2 ≥ 150 mmHg on admission was associated with increased in-hospital mortality.MethodsUsing data issued from a multicenter prospective trauma registry in France, we included trauma patients managed by the emergency medical services between May 2016 and March 2019 and admitted to a level I trauma center. Early hyperoxemia was defined as an arterial oxygen tension (PaO2) above 150 mmHg measured on hospital admission. In-hospital mortality was compared between normoxemic (150 > PaO2 ≥ 60 mmHg) and hyperoxemic patients using a propensity-score model with predetermined variables (gender, age, prehospital heart rate and systolic blood pressure, temperature, hemoglobin and arterial lactate, use of mechanical ventilation, presence of traumatic brain injury (TBI), initial Glasgow Coma Scale score, Injury Severity Score (ISS), American Society of Anesthesiologists physical health class > I, and presence of hemorrhagic shock).ResultsA total of 5912 patients were analyzed. The median age was 39 [26-55] years and 78% were male. More than half (53%) of the patients had an ISS above 15, and 32% had traumatic brain injury. On univariate analysis, the in-hospital mortality was higher in hyperoxemic patients compared to normoxemic patients (12% versus 9%, p

Published
2020

4. Association of preoperative COVID-19 and postoperative respiratory morbidity during the Omicron epidemic wave: the DROMIS-22 multicentre prospective observational cohort study

Author

Garnier, Marc, Constantin, Jean-Michel, Cinotti, Raphaël, Daoui, Chafia, Leone, Marc, Lapidus, Nathanaël, Hafiani, El Mahdi, Quesnel, Christophe, Imauven, Olivier, Lasocki, Sigismond, Rineau, Emmanuel, Léger, Maxime, Danguy des Deserts, Marc, Schmitt, Johan, Aries, Philippe, Gouel, Aurélie, Voulgaropoulos, Julia, Soldan, Laura, Deransy, Romain, Laurent, Quentin, Gayat, Etienne, Verdonk, Franck, Chaouche, Sabrina, Cambriel, Amélie, Degos, Vincent, Dupont, Julie, Daoud, Laura, Margetis, Dimitri, Salettes, Romain, Favreau, Malory, Noll, Eric, Pottecher, Julien, Diemunsch, Sophie, Abrard, Stanislas, Bidon, Cyril, Roy, Clémence, Destruhaut, Grégory, Ottolenghi, Laëtitia, Edouard, Damien, Lecinq, Agnès, Mercier, Frédéric, Cirenei, Cédric, Garrigue, Delphine, Jozefowicz, Elsa, Pariès, Marie, Espitalier, Fabien, Piat, Charlène, Descamps, Richard, Duchesne, Maëlle, Sigaut, Stéphanie, Thion, Laurie-Anne, Renard, Julie, Brocas, Elsa, Zbidi, Besma, Fki, Mohamed, Quemeneur, Cyril, Dufour, Guillaume, Bucciero, Mario, Rochon, Charles-Edouard, Delerue, Céline, Trehel-Tursis, Virginie, Raft, Julien, Rangeard, Olivier, Thiriet, Claire, Lagarde, Kevin, Pollet, Angélina, Pelen, Félix, Caillard, Anaïs, Penven, Philippe, Huet, Olivier, Puel, Floriane, Pichon, Xavier, Ligneres, Laetitia, Bleuze, Pauline, Deryckere, Stéphanie, Velly, Lionel, Simeone, Pierre, Andrianjatovo, Hery, Chipouline, Youri, Boolad, Mouna, Frasca, Denis, Plouviez, Quentin, Plaud, Benoit, Roland, Eric, Cheron-Leroy, Delphine, Figueiredo, Samy, Blanié, Antonia, Joannes-Boyau, Olivier, Monziols, Simon, Robin, Jean-Jacques, Biais, Matthieu, De Courson, Hugues, Degryse, Cécile, Do-Khac, Marie, Bonnet, Marie-Pierre, Mazeraud, Aurélien, Bardon, Jean, Bouchereau, Eléonore, Pastene, Bruno, Bezulier, Karine, Charbonneau, Hélène, Mrozek, Ségolène, Mayeur, Nicolas, Lopez, Sandrine, and Lecinq, Agnes

Published
2023
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6. Intrahospital trauma flowcharts — Cognitive aids for intrahospital trauma management from the French Society of Anaesthesia and Intensive Care Medicine (SFAR) and the French Society of Emergency Medicine (SFMU)

Author

Gauss, Tobias, Quintard, Hervé, Bijok, Benjamin, Bouhours, Guillaume, Clavier, Thomas, Cook, Fabrice, de Courson, Hugues, David, Jean-Stéphane, Duracher-Gout, Caroline, Garrigue, Delphine, Geeraerts, Thomas, Hamada, Sophie, Joannes-Boyau, Olivier, Jouffroy, Romain, Lamblin, Antoine, Langeron, Olivier, Lanot, Pierre, Lasocki, Sigismond, Leone, Marc, Mirek, Sébastien, Muller, Laurent, Pasquier, Pierre, Prunet, Bertrand, Perbet, Sébastien, Raux, Mathieu, Richards, Justin, Roger, Claire, Roquilly, Antoine, Weiss, Emmanuel, Bouzat, Pierre, and Pottecher, Julien

Published
2022
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7. Pilot deployment of a machine-learning enhanced prediction of need for hemorrhage resuscitation after trauma – the ShockMatrix pilot study.

Author

Gauss, Tobias, Moyer, Jean-Denis, Colas, Clelia, Pichon, Manuel, Delhaye, Nathalie, Werner, Marie, Ramonda, Veronique, Sempe, Theophile, Medjkoune, Sofiane, Josse, Julie, James, Arthur, Harrois, Anatole, Jeantrelle, Caroline, Raux, Mathieu, Pasqueron, Jean, Quesnel, Christophe, Godier, Anne, Boutonnet, Mathieu, Garrigue, Delphine, and Bourgeois, Alexandre

Abstract

Importance: Decision-making in trauma patients remains challenging and often results in deviation from guidelines. Machine-Learning (ML) enhanced decision-support could improve hemorrhage resuscitation. Aim: To develop a ML enhanced decision support tool to predict Need for Hemorrhage Resuscitation (NHR) (part I) and test the collection of the predictor variables in real time in a smartphone app (part II). Design, setting, and participants: Development of a ML model from a registry to predict NHR relying exclusively on prehospital predictors. Several models and imputation techniques were tested. Assess the feasibility to collect the predictors of the model in a customized smartphone app during prealert and generate a prediction in four level-1 trauma centers to compare the predictions to the gestalt of the trauma leader. Main outcomes and measures: Part 1: Model output was NHR defined by 1) at least one RBC transfusion in resuscitation, 2) transfusion ≥ 4 RBC within 6 h, 3) any hemorrhage control procedure within 6 h or 4) death from hemorrhage within 24 h. The performance metric was the F4-score and compared to reference scores (RED FLAG, ABC). In part 2, the model and clinician prediction were compared with Likelihood Ratios (LR). Results: From 36,325 eligible patients in the registry (Nov 2010—May 2022), 28,614 were included in the model development (Part 1). Median age was 36 [25–52], median ISS 13 [5–22], 3249/28614 (11%) corresponded to the definition of NHR. A XGBoost model with nine prehospital variables generated the best predictive performance for NHR according to the F4-score with a score of 0.76 [0.73–0.78]. Over a 3-month period (Aug—Oct 2022), 139 of 391 eligible patients were included in part II (38.5%), 22/139 with NHR. Clinician satisfaction was high, no workflow disruption observed and LRs comparable between the model and the clinicians. Conclusions and relevance: The ShockMatrix pilot study developed a simple ML-enhanced NHR prediction tool demonstrating a comparable performance to clinical reference scores and clinicians. Collecting the predictor variables in real-time on prealert was feasible and caused no workflow disruption. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Prévention du risque thromboembolique veineux et surveillance de l’hémostase chez les patients hospitalisés pour COVID-19 : propositions réactualisées (avril 2021). Groupe d’intérêt en hémostase périopératoire (GIHP) et groupe d’étude sur l’hémostase et la thrombose (GFHT)

Author

Godon, Alexandre, Tacquard, Charles Ambroise, Mansour, Alexandre, Garrigue, Delphine, Nguyen, Philippe, Lasne, Dominique, Testa, Sophie, Levy, Jerrold H., Albaladejo, Pierre, Gruel, Yves, Susen, Sophie, Godier, Anne, le GIHP, pour, and GFHT, le

Published
2021
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9. Prevention of venous thromboembolism and haemostasis monitoring in patients with COVID-19: Updated proposals (April 2021): From the French working group on perioperative haemostasis (GIHP) and the French study group on thrombosis and haemostasis (GFHT), in collaboration with the French society of anaesthesia and intensive care (SFAR)

Author

Albaladejo, P., Blais, N., Bonhomme, F., Borel-Derlon, A., Cohen, A., Collet, J.-P., de Maistre, E., Fontana, P., Garrigue Huet, D., Godier, A., Gruel, Y., Godon, A., Ickx, B., Laporte, S., Lasne, D., Llau, J., Le Gal, G., Lecompte, T., Lessire, S., Levy, J.H., Longrois, D., Madi-Jebara, S., Mansour, A., Mazighi, M., Mismetti, P., Morange, P.E., Motte, S., Mullier, F., Nathan, N., Nguyen, P., Pernod, G., Rosencher, N., Roullet, S., Roy, P.M., Schlumberger, S., Sié, P., Steib, A., Susen, S., Tacquard, C.A., Testa, S., Vincentelli, A., Zufferey, P., Boissier, E, Dumont, B, James, C, Siguret, V., Godon, Alexandre, Tacquard, Charles Ambroise, Mansour, Alexandre, Garrigue, Delphine, Nguyen, Philippe, Lasne, Dominique, Testa, Sophie, Levy, Jerrold H., Albaladejo, Pierre, Gruel, Yves, Susen, Sophie, and Godier, Anne

Published
2021
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10. Guidelines for the acute care of severe limb trauma patients

Author

Pottecher, Julien, Lefort, Hugues, Adam, Philippe, Barbier, Olivier, Bouzat, Pierre, Charbit, Jonathan, Galinski, Michel, Garrigue, Delphine, Gauss, Tobias, Georg, Yannick, Hamada, Sophie, Harrois, Anatole, Kedzierewicz, Romain, Pasquier, Pierre, Prunet, Bertrand, Roger, Claire, Tazarourte, Karim, Travers, Stéphane, Velly, Lionel, Gil-Jardiné, Cédric, and Quintard, Hervé

Published
2021
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11. Withholding and withdrawal of life-sustaining therapy in 8569 trauma patients: A multicentre, analytical registry study

Author

Haddam, Malik, Kubacsi, Laura, Hamada, Sophie, Harrois, Anatole, James, Arthur, Langeron, Olivier, Boutonnet, Mathieu, Holleville, Mathilde, Garrigue, Delphine, Leclercq, Marion, Hanouz, Jean-Luc, Pottecher, Julien, Audibert, Gérard, Cardinale, Mickael, Vinour, Hélène, Zieleskiewicz, Laurent, Resseguier, Noemie, and Leone, Marc

Published
2022
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13. Early management of severe abdominal trauma

Author

Bouzat, Pierre, Valdenaire, Guillaume, Gauss, Tobias, Charbit, Jonhatan, Arvieux, Catherine, Balandraud, Paul, Bobbia, Xavier, David, Jean-Stéphane, Frandon, Julien, Garrigue, Delphine, Long, Jean-Alexandre, Pottecher, Julien, Prunet, Bertrand, Simonnet, Bruno, Tazarourte, Karim, Trésallet, Christophe, Vaux, Julien, Viglino, Damien, Villoing, Barbara, Zieleskiewicz, Laurent, Gil-Jardiné, Cédric, and Weiss, Emmanuel

Published
2020
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16. Prise en charge des traumatisés pelviens graves à la phase précoce (24 premières heures)

Author

Incagnoli, Pascal, Puidupin, Alain, Ausset, Sylvain, Beregi, Jean-Paul, Bessereau, Jacques, Bobbia, Xavier, Brun, Julien, Brunel, Élodie, Buléon, Clément, Choukroun, Jacques, Combes, Xavier, David, Jean Stéphane, Desfemme, François-Régis, Garrigue, Delphine, Hanouz, Jean Luc, Kipnis, Éric, Plénier, Isabelle, Rongieras, Frédéric, and Vivien, Benoît

Published
2019
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17. Gestion des agents antiplaquettaires en cas de procédure invasive non programmée ou d’hémorragie. Propositions du Groupe d’intérêt en hémostase périopératoire (GIHP) et du Groupe français d’études sur l’hémostase et la thrombose (GFHT) en collaboration avec la Société française d’anesthésie et de réanimation (SFAR)

Author

Belisle, S., Blais, N., Borel-Derlon, A., Borg, J.Y., Bosson, J.-L., Cohen, A., Faraoni, D., Garrigue Huet, D., Guay, J., Hardy, J.F., Huet, Y., Laporte, S., Levy, J.H., Llau, J., Le Gal, G., Lessire, S., Longrois, D., Madi-Jebara, S., Marret, E., Mas, J.L., Meyer, G., Mismetti, P., Morange, P.E., Motte, S., Mullier, F., Nathan, N., Ozier, Y., Pernod, G., Rosencher, N., Roullet, S., Roy, P.M., Samama, C.M., Schlumberger, S., Schved, J.F., Sié, P., Steib, A., Susen, S., van Belle, E., van Der Linden, P., Zufferey, P., Godier, Anne, Garrigue, Delphine, Lasne, Dominique, Fontana, Pierre, Bonhomme, Fanny, Collet, Jean-Philippe, de Maistre, Emmanuel, Ickx, Brigitte, Gruel, Yves, Mazighi, Mikael, Nguyen, Philippe, Vincentelli, André, Albaladejo, Pierre, and Lecompte, Thomas

Published
2019
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18. Early management of severe pelvic injury (first 24 hours)

Author

Incagnoli, Pascal, Puidupin, Alain, Ausset, Sylvain, Beregi, Jean Paul, Bessereau, Jacques, Bobbia, Xavier, Brun, Julien, Brunel, Elodie, Buléon, Clément, Choukroun, Jacques, Combes, Xavier, David, Jean Stephane, Desfemmes, François-Régis, Garrigue, Delphine, Hanouz, Jean-Luc, Plénier, Isabelle, Rongieras, Fréderic, Vivien, Benoit, Gauss, Tobias, Harrois, Anatole, Bouzat, Pierre, and Kipnis, Eric

Published
2019
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19. Strategic proposal for a national trauma system in France

Author

Gauss, Tobias, Balandraud, Paul, Frandon, Julien, Abba, Julio, Ageron, Francois Xavier, Albaladejo, Pierre, Arvieux, Catherine, Barbois, Sandrine, Bijok, Benjamin, Bobbia, Xavier, Charbit, Jonathan, Cook, Fabrice, David, Jean-Stephane, Maurice, Guillaume De Saint, Duranteau, Jacques, Garrigue, Delphine, Gay, Emmanuel, Geeraerts, Thomas, Ghelfi, Julien, Hamada, Sophie, Harrois, Anatole, Kobeiter, Hicham, Leone, Marc, Levrat, Albrice, Mirek, Sebastien, Nadji, Abdel, Paugam-Burtz, Catherine, Payen, Jean Francois, Perbet, Sebastien, Pirracchio, Romain, Plenier, Isabelle, Pottecher, Julien, Rigal, Sylvain, Riou, Bruno, Savary, Dominique, Secheresse, Thierry, Tazarourte, Karim, Thony, Frederic, Tonetti, Jerome, Tresallet, Christophe, Wey, Pierre-Francois, Picard, Julien, and Bouzat, Pierre

Published
2019
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20. Ferric derisomaltose and tranexamic acid, combined or alone, for reducing blood transfusion in patients with hip fracture (the HiFIT trial): a multicentre, 2 × 2 factorial, randomised, double-blind, controlled trial

Author

Lasocki, Sigismond, primary, Capdevila, Xavier, additional, Vielle, Bruno, additional, Bijok, Benjamin, additional, Lahlou-Casulli, Maria, additional, Collange, Vincent, additional, Grillot, Nicolas, additional, Danguy des Deserts, Marc, additional, Duchalais, Alexis, additional, Delannoy, Bertrand, additional, Drugeon, Bertrand, additional, Bouzat, Pierre, additional, David, Jean-Stéphane, additional, Rony, Louis, additional, Loupec, Thibault, additional, Léger, Maxime, additional, Rineau, Emmanuel, additional, Bouhours, Guillaume, additional, Lasocki, Sigismond, additional, Lebail, Adeline, additional, Parot-Schinkel, Elsa, additional, Capdevilla, Xavier, additional, Mounet, Benjamin, additional, Swisser, Fabien, additional, Cinotti, Raphael, additional, Asehnoune, Karim, additional, Roquilly, Antoine, additional, Beloeil, Hélène, additional, Parent, Sébastien, additional, Desebbe, Olivier, additional, Guenezan, Jeremy, additional, Drevet, Sabine, additional, Gavazzi, Gaetan, additional, Greze, Jules, additional, and Garrigue, Delphine, additional

Published
2023
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21. Position du GIHP sur les tests viscoélastiques : quelle place pour quelle indication en situation hémorragique ?

Author

Albaladejo, Pierre, Belisle, Sylvain, Blais, Normand, Bonhomme, Fanny, Borel-Derlon, Annie, Borg, Jeanne-Yvonne, Bosson, Jean-Luc, Cohen, Ariel, Collet, Jean-Philippe, de Maistre, Emmanuel, Faraoni, David, Fontana, Pierre, Garrigue Huet, Delphine, Godier, Anne, Gruel, Yves, Guay, Joanne, Hardy, Jean-François, Huet, Yann, Ickx, Brigitte, Laporte, Silvy, Lasne, Dominique, Levy, Jerrold H., Llau, Juan, Le Gal, Grégoire, Lecompte, Thomas, Lessire, Sarah, Longrois, Dan, Madi-Jebara, Samia, Marret, Emmanuel, Mas, Jean-Louis, Mazighi, Mikael, Mismetti, Patrick, Morange, Pierre-Emmanuel, Motte, Serge, Mullier, François, Nathan, Nathalie, Nguyen, Philippe, Ozier, Yves, Pernod, Gilles, Rosencher, Nadia, Roullet, Stéphanie, Roy, Pierre-Marie, Samama, Charles Marc, Schlumberger, Sylvie, Schved, Jean-François, Sié, Pierre, Steib, Annick, Susen, Sophie, van Belle, Eric, Van der Linden, Philippe, Vincentelli, André, Zufferey, Paul, and Garrigue, Delphine

Published
2018
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22. Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

Author

Klimscha, Walter, Konecny, Regina, Luntzer, Robert, Morawk-Wintersperger, Ulrike, Neiger, Franz, Rustemeyer, Lydia, Breschan, Christian, Frey, Denise, Platzer, Manuela, Germann, Reinhard, Oeding, Joachim, Stoegermüller, Birgit, Ziegler, Bernhard, Brotatsch, Philipp, Gutmann, Anton, Mausser, Gerlinde, Messerer, Brigitte, Toller, Wolfgang, Vittinghoff, Maria, Zangl, Gregor, Seidel-Ahyai, Natascha, Hochhold, Christoph, Kroess, Ruth, Paal, Peter, Cnudde, Steven, Coucke, Patricia, Loveniers, Birgit, Mitchell, John, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Veyckemans, Francis, Coppens, Marc, De Hert, Stefan, Heyse, Björn, Neckebroek, Martine, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Van Den Eynde, Nancy, Vanpeteghem, Caroline, Wyffels, Piet, Lalot, Michaël, Lechat, Jean-Paul, Stevens, France, Casaer, Sari, De Groote, Françoise, De Pooter, Françoise, De Villé, Andrée, Gerin, Marc, Magasich, Natalia, Sanchez Torres, Cristel, Van Deenen, Denise, Berghmans, Johan, Himpe, Dirk, Roofthooft, Eva, Joukes, Ellen, Smitz, Carine, Van Reeth, Veronique, Huygens, Christel, Lauweryns, Julie, De Smet, Karen, Najafi, Nadia, Poelaert, Jan, Van de Velde, Anne, Van Mossevelde, Veerle, Bekavac, Ivan, Butkovic, Diana, Heli Litvic, Dubravka, Kerovec Soric, Ivana, Maretic, Hrvoje, Moscatello, Djurdjica, Popovic, Ljiljana, Micici, Slobodan, Stuck Tus, Ivana, Kalagac Fabris, Lada, Simurina, Tatjana, Sulen, Nina, Kesic-Valpotic, Gordana, Djapic, Dajana, Žurek, Jirí, Jureckova, Lucie, Mackova, Iveta, Skacel, Monika, Weinlichova, Stanislava, Divák, Jan, Frelich, Michal, Urbanec, René, Biskupova, Vera, Mixa, Vladimir, Pavlickova, Jana, Afshari, Arash, Bøttger, Morten, Ellekvist, Marguerite B., Johansen, Mathias, Ingeborg Madsen, Birgitte, Christian Nilsson, Jens, Schousboe, Birgitte MB, Clausen, Nicola G., Hansen, Tom G., Phaff Steen, Nick, Ilmoja, Mari-Liis, Tonise, Virge, Karjagin, Juri, Kikas, Reet, Isohanni, Mika, Lyly, Anniina, Takala, Annika, Happo, Johanna, Kiviluoma, Kai, Martikainen, Kati, Aantaa, Riku, Manner, Tuula, Vilo, Sanna, Amory, Catherine, Ludot, Hugues, Lambotte, Patricia, Busche, René, Jacqmarcq, Olivier, Lejus, Corinne, Corouge, Julien, Erb, Christian, Garrigue, Delphine, Gillet, Patricia, Laffargue, Anne, Lambelin, Veronique, Le Freche, Hélène, Peresbota, Daliana, Richart, Pierre, Berton, Jerome, Chapotte, Catherine, Colbus, Laurent, Lehousse, Thierry, Monrigal, Jean, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Batoz, Hélène, Bordes, Maryline, Didier, Anne, Hamonic, Yann, Lagarde, Sylvaine, Nouette-Gaulain, Karine, Semjen, François, Zaghet, Brigitte, Dekens, Jacky, Delcuze, Axelle, Dupont, Hervé, Legrand, Aurélien, Raffoflandreur, Celine, Audren, Noémie, Camus, Blandine, Cartal, Marielle, Chazelet, Chantal, Davin, Isabelle, Guillier, Marion, Desjeux, Luc, Larcher, Claire, Grein, Elodie, Leclercq, Mickeal, Levitchi, Roxana, Rosu, Lilica, Simon, Dominique, Zang, Aurélien, Migeon, Anne, Gagey, Anne-Charlotte, Bourdaud, Nathalie, Carre, Anne-Charlotte, Duflo, Frédéric, Riche, Jean-Claude, Robert, Philippe, Druot, Emilie, Maupain, Olivier, Orliaguet, Gilles, Sabau, Lucie, Taright, Hanna, Uhrig, Lynn, Verchere-Montmayeur, Juliette, Debrabant, Lise, Pilla, Clotaire, Podvin, Alexandre, Roth, Benjamin, Dahmani, Souhayl, Julien-Marsollier, Florence, Sabourdin, Nada, Alexandri, Bogdan, Brezac, Gilles, de la Brière, Francois, Hayem, Catherine, Lhubat, Elizabeth, Paul Mission, Jean, Rémond, Charlotte, Dadure, Christophe, Maniora, Maud, Marie, Anais, Pirat, Philippe, Saour, Anne-Charlotte, Sola, Chrystelle, Ecoffey, Claude, Wodey, Eric, Adam, Christian, Standl, Thomas, Schindler, Ehrenfried, Yamamoto, Tomohiro, Brackhahn, Michael, Eich, Christoph Bernhard, Guericke, Holger, Kindermann, Petra, Laschat, Michael, Schink, Cornel, Wappler, Frank, Hoehne, Claudia, Skordou, Natalia, Ulrici, Johanna, Jetzek-Zader, Martin, Kienbaum, Peter, Meyer-Treschan, Tanja, Picker, Olaf, Schaefer, Maximilian S., Mielke, Golo, Baethge, Sabine, Ramminger, Axel, Bauer, Martin, Bollinger, Matthias, Hinz, José, Quintel, Michael, Russo, Sebastian G., Bauer, Michael, Geil, Dfominik, Kortgen, Andreas, Preussler, Niels-Peter, Hofmann, Ulrich, Raber, Manfred, Reindl, Doris, Becke, Karin, Oppenrieder, Karin, Schierlinger, Bettina, Roth, Jens, Funk, Wolfgang, Fischer, Thomas, Gernoth, Christian, Wiefelspütz, Christina, Volger, Hauke, Zederer, Nicole, Diers, Anja, Huber, Matthias, Schorer, Clemens, Weyland, Andreas, Schwarzkopf, Konrad, Grau, Catharina, Roth, Winfried, Holy, Rolf, Mader, Thomas, Peter, Laura, Supthut, Hauke, Kuehhirt, Thomas, Milde, Alexander, Fiedler, Fritz, Isselhorst, Carsten, Grundmann, Ulrich, Pattar, Alexander, Reinert, Jennifer, Ehm, Birgit, Fritzsche, Katrin, Gaebler, Ralf, Meybohm, Patrick, Hein, Maximilian, Guzman, Ines, Jokinen, Johanna, Kranke, Peter, Goebel, Ulrich, Harris, Sarah, Eisner, Christoph, Ochsenreiter, Miriam, Schoeler, Michael, Thil, Elke, Ellerkmann, Richard, Hoeft, Andreas, Neumann, Claudia, Weber, Stefan, Keilhauer, Julia, Kloessing, Jan, Schramm, Michael, Trieschmann, Uwe, Knauss, Kristina, Sinner, Barbara, Steinmann, Johannes, Koessler, Herbert, Kalliardou, Evagelia, Malisiova, Anna, Tsiotou, Adelais, Chloropoulou, Pelagia, Chrysi, Mpratzou, Iordanidou, Despoina, Ntavlis, Merkourios, Boda, Krisztina B, Guerin, Christilynn, Irwin, Janice, Magner, Claire, Nakhjavani, Solmaz, O'Hare, Brendan, Galvin, Deborah, Jamil, Yosry, Lesmes, Carlos, Barak, Yuri, Fisher, Haran, Kachko, Ludmyla, Katz, Jacob, Kirilov, Dmitry, Levinzon, Michael, Manevich, Yair, Nekrasov, Konstantin, Peled, Elia, Sanko, Elena, Schmain, Dmitri, Sheinkin, Olga, Simhi, Eliahu, Tarabikin, Alex, Trabkin, Evelina, Yagudaev, Irena, Zeitlin, Yelena, Zunser, Igor, Cerutti, Elisabetta, Maddalena Schellino, Maria, Valzan, Silvia, Lucia Pinciroli, Rosa, Bortone, Luciano, Cerati, Giorgia, Salici, Fabiana, Bussolin, Leonardo, Rizzo, Giuliana, Rossetti, Francesca, Marchesini, Laura, Tesoro, Simonetta, De Lorenzo, Brita, Guarracino, Fabio, Kuppers, Beate, Astuto, Marinella, Pitino, Sofia, Scalisi, Rita, Scordo, Lucia, D'Alessandro, Sandra, Dei Giudici, Luigi, Farinelli, Ivano, Lofino, Giuseppe, Marchetti, Giuliano, Giuseppe Picardo, Sergio, Reali, Simone, Vittori, Alessandro, Antonio Idone, Francesco, Sammartino, Maria, Sbaraglia, Fabio, Barbera, Cinzia, Bevilacqua, Michela, Cento, Valeria, Disma, Nicola, Kotzeva, Svetlana, Mameli, Leila, Montobbio, Giovanni, Passariello, Leandro, Punzo, Cinzia, Sileo, Rosanna, Viacava, Rosanna, Volpe, Claudia, Zanaboni, Clelia, Calderini, Edoardo, Genco, Daniele, Neri, Simona, Ottolina, Davide, Camporesi, Anna, Izzo, Francesca, Salvo, Ida, Wolfler, Andrea, Sanna, Andrea, Sciascia, Angela, Stoia, Paolo, Guddo, Annamaria, Lapi, Maria, Ivani, Giorgio, Longobardo, Annalisa, Mossetti, Valeria, Pedrotti, Dino, Grazzini, Maurizia, Meneghini, Luisa, Metrangolo, Salvatore, Michelon, Stefania, Minardi, Carmelo, Tognon, Costanza, Zadra, Nicola, Busi, Ilaria, Khotcholava, Magda, Guido Locatelli, Bruno, Sonzogni, Valter, Starita, Giusi, Almenrader, Nicole, Aurilio, Caterina, Sansone, Pasquale, Albarello, Raffaella, Bracci, Paolo, Cecini, Mariateresa, Cristina Mondardini, Maria, Pasini, Lorena, Vason, Milo, Zani, Gianluca, Zoppellari, Roberto, Pistidda, Laura, Cortegiani, Andrea, Maurizio Raineri, Santi, Hasani, Antigona, Hashimi, Medita, Ancupans, Agris, Barzdina, Arta, Straume, Zane, Zundane, Anda, Chlopin, Mikhail, Gestautaite, Dalia, Lukosiene, Laura, Paliokaite, Evelina, Razlevice, Ilona, Armoniene, Inesa, Bernotiene, Aurelija, Daugelavicius, Vidunas, Dockiene, Ilona, Gaidelyte, Lina, Saviciene, Nijole, Krikstaponiene, Jolita, Sidlovskaite-Baltake, Dominika, Stasevski, Vladyslav, Vaitoskaite, Agne, Gatt, David, Mifsud, Stephanie, Zammit, Simone, Allison, Celia, Aslami, Hamid, Eberl, Susanne, van Stijn, Mireille F M, Stevens, Markus F, Punt, Kees, van Osch, Rob, Bauwman, Arthur, Scholten, Harm, Svircevic, Vesna, Adriaens, Veronique, Dirckx, Maaike, Dogger, Jaap, Dons-Sinke, Ilse, Machotta, Andreas, Moors, Xavier, Rad, Mandana, Staals, Lonneke, van der Knijff - van Dortmont, Anouk, van der Marel, Caroline, Sieben, Anne, van der Zwan, Tim, Veldhuizen, Marianne, Alders, David, Buhre, Wolfgang, Vermeulen, Petronella M, Engel, Nicole, Vossen, Carine, Mahadewsing, Ravin, Meijer, Patrick, Gerling, Volker, van der Schatte Olivier, Roelof, van Doorn, Thea, Vons Mark Hendriks, Kristy, Lako, Sandra, jan Scheffer, Gert, Tielens, Luc, Voet, Marieke, Absalom, Anthony, Bergsma, Margot, Spanjer, Vera, Spanjersberg, Rob, van de Riet, Yvette, Volkers, Martin, de Graaff, Jurgen C., Hopman, Geranne A.J., Kappen, Teus H., Hannie, J., Megens, A.M., Numan, Sandra C., Schouten, Anton N.J., Turner, Nigel M., Van Der Werff, Désirée B.M., Wensing, Renee T.M., Ephraim, Erik, Nolte, Claire, Reikvam, Tore, Fredrik Lund, Ole, Skaaden, Lene, Marthe Ballovarre, Kari, Bakken Boerke, Wenche, Grindheim, Guro, Lindenskov, Pal H H, Beate Solas, Anne, Sponheim, Sjur, Ullensvang, Kyrre, Viken, Oddbjorn, Marie Drage, Inger, Gymoese Berthelsen, Kasper, Anders Kroken, Bjørn, Bergland, Unni, Pryzmont, Miroslaw, Talalaj, Mariola, Wasiluk, Malgorzata, Zalewska, Dorota, Damps, Maria, Siemek-Mitela, Jadzia, Wieczorek, Pawel, Juzwa, Magdalena, Rosada-Kurasinska, Jowita, Bartkowska-Sniatkowska, Alicja, Cettler, Maciej, Kopycinska, Renata, Rudewicz, Iwona, Sobczyk, Jaek, Wojciechowski, Dariusz, Baranowski, Artur, Basiewicz, Ewa, Mierzewska-Schmidt, Magdalena, Retka, Wlodzimierz, Sawicki, Piotr, Checinska, Magdalena, Zielinska, Marzena, Zurawska, Magdalena, Leal, Teresa, Mascarenhas, Catia, Pedro Pina, António, Joao Susano, Maria, Moniz, Antonio, Teresa Rocha, Maria, Calvao Santos, Carolina, Domingas Patuleia, M, Pereira, Ricardo, Roxo, Helena, Amaral, Rosa, Guedes, Isabel, Gomes, Cristina, Gonçalves, Marta, Salgado, Helena, Santos, Maria, Rodrigues, Sara, Sa, Angela, Machado, Elvira, Pé d'Arca, Sandra, Seabra, Manuel, Mihaela Gheorghe, Ligia, Ivascu, Constantin, Moraru-Draghici, Lucia, Suvejan, Mirela, Babici, Remus, Eniko, Kovacs, Hogea, Cristiana, Mihaela, Dubau, Nicoleta, Daraban, Barbunc, Danut, Maria Nistor, Alina, Stefan, Violeta, Catalina Ionescu, Gabriela, Davidescu, Irina, Teodora Nastase, Alina, Dumitru Rusu, Florin, Badarau, Victoria, Cindea, Iulia, Moscaliuc, Melania, Olteanu, Dana, Petrescu, Luxita, Ceuca, Daniela, Galinescu, Irena, Badeti, Rodica, Capusan, Alin, Cucui-Cozma, Cosmina, Popescu, Barbura, Cimpeanu, Luminita, Birliba, Mihaela-Petronela, Miulescu, Magdalena, Balamat, Stefania, Gurita, Adriana, Ilie, Luminita, Mocioiu, Gabriel, Pick, Darina, Sirghie, Rodica, Tabacaru, Radu, Trante, Irinel, Horhota, Lucian, Bandrabur, Daniela, Ciobanu, Tudor, Cuciuc, Veaceslav, Munteanu, Valentin, Olaru, Valentin, Paiu, Corneliu, Savu, Anca, Trifan, Oana, Elena Malos, Anca, Glazunov, Anton, Ivanov, Alexander, Poduskov, Evgeny, Popov, Alexander, Guskov, Igor, Lugovoy, Alexander, Nechaev, Vladislav, Ovezov, Alexey, Basov, Mikhail, Kochkin, Vladimir, Lazarev, Vladimir, Chizhov, Dmitri, Ostreikov, Ivan, Tolasov, Konstantin, Budic, Ivana, Marjanovic, Vesna, Draskovic, Biljana, Pandurov, Marina, Simin, Jovana, Dolinaj, Vladimir, Janjevic, Dusanka, Mandras, Ana, Mircetic, Maja, Petrovic, Sladjana, Rebac, Vlatka, Slavkovic, Bojana, Stevanovic, Vesna, Velcev, Ana, Knezevic, Mirjana, Milojevic, Irina, Puric, Selena, Simic, Irena, Stevic, Marija, Stranjanac, Vladimir, Simic, Dusica, Cabanova, Barbora, Hanula, Miloslav, Grynyuk, Andry, Berger, Jelena, Cerne, Uros, Nastran, Andraz, Pirc, Dejan, Popic, Rok, Stupnik, Spela, Rubio, Paloma, del Río, Cristina, Benito, Pilar, Pino, Gema, Gutierrez, Ignacio, Gutierrez Valcarcel, Andrea, León Carsi, Irene, Perez Garcia, Anibal, López Galera, Sílvia, Marco Valls, Joan, Ricol Lainez, Laura, Vallejo Tarrat, Andrea, Artes, David, Banus, Ester, Chirichiello, Luca, De Abreu, Leidy, De Josemaria, Belen, Helena Gaitan, M, Garces, Antonio, Lazaro, Juan J, Manen Berga, Ferran, Molies, Dolors, Monclus, Enric, Navaro, Montserrat, Pamies, Carmen, Perelló, Marina, Prat, Mar, Ribo, Laura, Angeles Sanz, M, Serrano, Silvia, Sola Ruiz, Eva, Anuncia Escontrela Rodríguez, Blanca, Maria Gago Martinez, Andrea, Martínez Ruiz, Alberto, De La Cruz Benito, Fausto, Gabilondo Garcia, Gustavo, Martinez Maldonado, Ever, Noriega, Bryant, Oller Duque, Lara, Olmos Mendez, Alberto, Perez- Ferrer, Antonio, Reinoso Barbero, Francisco, Acevedo Bambaren, Ismael, Domínguez, Fernando, Franco, Teresa, Jiménez, Anabel, Melero, Alicia, Feliu, Montserrat, García, Irene, Montferrer, Núria, Munar, Francisca, Muro, Cristina, Nuño, Rosario, Perera, Remel, Schmucker, Erika, Börjesson, Glenda, Gillberg, Lars, Castellheim, Albert, Sandström, Kerstin, Bauer, Annette, Roos, Torbjörn, Hedlund, Lars, Boegli, Yann, Dolci, Mirko, Marcucci, Carine, Spahr-Schopfer, Isabelle, Habre, Walid, Pellegrini, Michel, Book, Malte, Errass, Loreen, Riggenbach, Christine, Casutt, Mattias, Hölzle, Martin, Hurni, Thomas, Jöhr, Martin, Mauch, Jacqueline, Anselmi, Luciano, Anselmi, Irene, Jacomet, Alfred, Oberhauser, Markus, Wossner, Stephanie, Zettl, Angelika, Erb, Thomas, Mackiewicz, Tomasz, Simitzes, Helena, Ozer, Yetkin, Takil, Arzu, Alanoglu, Zekeriyya, Bermede, Onat, Cakar Turhan, K.Sanem, Alkis, Neslihan, Yildirim Guclu, Cigdem, Ceyda Meco, Basak, Hatipoglu, Zehra, Ozcengiz, Dilek, Begec, Zekine, Ilksen Toprak, Huseyin, Kendigelen, Pinar, Cigdem Tütüncü, Ayse, Karadeniz, Meltem Savran, Seyhan Ozkan, Tulay, Sivrikoz, Nuket, Kemal Arslantas, Mustafa, Hizal, Ayse, Tore Altun, Gülbin, Umuroglu, Tumay, Baris, Sibel, Kazak Bengisun, Zuleyha, Goncharenko, Galyna, Khrapak, Maksym, Klymenko, Tetyana, Pavlenko, Vitaliy, Prysiazhniuk, Dmytro, Rudio, Olga, Varyvoda, Mykhailo, Vodianytskyi, Sergii, Boryshkevych, Ivanna, Kyselova, Iryna, Trikash, Nikolay, Albokrinov, Andrew, Perova-Sharonova, Valentina, Sklyar, Vitaliy, Surkov, Denis, Abdelaal, Amr, Barber, Nicola, Checuti, Sarah, Godsiff, Leisha, Johanne, Lynch, Simpson, Joanna, Underhill, Helen, Diwan, Rishi, Kelgeri, Nivedita, Masip, Nuria, Ravi, Radha, Roberts, Steve, Cillis, Annagrazia, Marcus, Ritchie, Merella, Federica, Love, David, Baraggia, Paolo, Bird, Victoria, Hussey, Joseph, Alderson, Peter, Bartholomew, Karen, Moncreiff, Michael, Davidson, Sarah, Hare, Alison, Kotecha, Ami, Lee, Corina, Liyanage, Ganga, Patel, Shivali, Samani, Amee, Abou-Samra, Mark, Boyd, Matthew, Hullatt, Laurence, Levy, David, Pauling, Mark, Sharman, Sarah-Jane, Smith, Natalie, Rutherford, John, Cavalier, Alison, Locke, Christie, Sage, Frederic, Bapat, Smita, Hammerschlag, Jacinda, Ioannou, Ioannis, King, Stephanie, Pegg, Rachel, Salota, Vishal, Sketcher, Jonathan, Thadsad, Muthu, Zeitlin, Deborah, Jack, Ewan, Lang, Colin, Ahmed, Samira, Ayyash, Reema, Bari, Francoise, Bell, Sarah J, Elizabeth Biercamp, Claire, Briggs, Sandra, Gabriella Elena Clement, Maria, Dalton, Mark, Ali Eissa Eid, Mohamed, Gandhi, Monica, Harmen Herrema, Idse, Khaffaf, Ranj, Jeng Min Law, Savio, McClintock, Joanna, Ireland, Nicholas, Majid Saleem, Mohammed, Smith, Fiona, Cohen, Marc, Lee, Clover-Ann, O'Donahue, Lizanne, Powell, Alex, Rawlinson, Ellen, Snoek, Aarjan, Weiss, Katja, Wellesley, Hugo, Crawford, Michael, Abdel-Hafiz, Mostafa, Day, Alexandra, Rajamani, Balaji, Saha, Rita, Wright, Dave, Chee, Lew-Chin, Bew, Stephanie, Homer, Rachel, Malarkkan, Nalini, Wolfe Barry, Juliet, Angadi, Pradeep, Cagney, Brid, De Melo, Eric, Dekker, Elsa, Helm, Emma, Jones, Gareth, Peiris, Kawshala, Russell, William, Slater, Patricia, Sodhi, Puja, Browning, Mike, Phillips, Trudie, Van Hecke, Rachel, Muir, Vimty, Singh, Piyush, Soskova, Tereza, Cumming, Craig, Farquharson, Pamela, Pearson, Karen, Shaw, Neil, Whiteside, Jonathan, Whyte, Emma, Byers, Gordon, Davies, Kay, Engelhardt, Thomas, Faliszewski, Isabella, Johnston, Graham, Kaufmann, Nils, Kusnirikova, Zuzana, Wilson, Graham, Carachi, Peter, Makin, Andrew, Foster, Brian, Lipczynski, Dariusz, Mawer, Rebecca, Rutherford, William, Rogerson, David, Rushman, Sarah, Taylor, Christopher, Tomlinson, William, Dix, Philippa, Woodward, Tom, Bell, Graham, Boyle, David, Cloherty, Marianne, Cullen, Julia, Cullen, Pauline, Fairgrieve, Ross, Ghent, Robert, Glasgow, Russell, Gordeeva, Elena, Harden, Alison, Hivey, Sarah, Jerome, Kevin, McKee, Lesley, Morton, Neil, Pribul, Vicky, Sinclair, John, Steiner, Maria, Steward, Heather, Sweeney, Lorraine, Thomson, Wendy, Whiteside, Jeanette, Dalton, Andrew, Ross, Mark, Smith, Carolyn, Allen, Claire, Anders, Nicola, Barlow, Victoria, Bassett, Mike, Darwin, Leanne, Davison, Rachel, Diacono, Jacques, Hobbs, Amy, Hutchinson, Adel, Lomas, Bernadette, Lonsdale, Hannah, Nasser, Leila, Oshan, Vimmi, Patel, Pradip, Raistrick, Christopher, Scott-Warren, Victoria, Talbot, Laura, Wai, Carolynn, Childs, Sophie, Dickinson, Matthew, Bloomfield, Tom, Garrioch, Sweyn, Watson, Karen, Gaynor, James, Harrison, Richard, Lee, Juliette, Blythe, Elizabeth, Dorman, Teresa, Eissa, Ayman, Ellwood, James, Gooch, Ingrid, Hearn, Robert, Hodgetts, Vanessa, John, Robert, Kirton, Christine, Ladak, Nadia, Morgan, Judith, Plant, Nina, Shepherd, Elizabeth, Short, Judith, Stack, Charles, Steel, Simon, Taylor, Matthew, Thomas, Deborah, Wilson, Catharine, Wilson-Smith, Elaine, Bradbury, Carol L., Hussain, Nageena, Mayell, Antonia, Mesbah, Ahmed, Qureshi, Arif, Vaidyanath, Chandra, Geary, Tim, Hawksworth, Chris, Parasuraman, Tamaraichelvi, Perry, Nicole, Banerjee, Indrani, Barr, Katharine, Butler, Patrick, Davies, Jack, Flewin, Lisa, Gande, Richard, Montague, James, Plumb, James, Pratt, Thomas, Sutherland, Paul, Vail, Hannah, Wilkins, Andrew, Hunter, Catherine, Russell, Susan, Thomas, Alun, Mifsud, Mark, Strachan, Dominic, Leva, Brigitte, Plichon, Benoit, Harlet, Pierre, Virag, Katalin, Hansen, Tom G, Morton, Neil S, and Boda, Krisztina

Published
2017
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23. Chest trauma: First 48 hours management

Author

Bouzat, Pierre, Raux, Mathieu, David, Jean Stéphane, Tazarourte, Karim, Galinski, Michel, Desmettre, Thibault, Garrigue, Delphine, Ducros, Laurent, Michelet, Pierre, Freysz, Marc, Savary, Dominique, Rayeh-Pelardy, Fatima, Laplace, Christian, Duponq, Raphaelle, Monnin Bares, Valérie, D’Journo, Xavier Benoît, Boddaert, Guillaume, Boutonnet, Mathieu, Pierre, Sébastien, Léone, Marc, Honnart, Didier, Biais, Mathieu, and Vardon, Fanny

Published
2017
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25. Endotheliopathy Is Induced by Plasma From Critically Ill Patients and Associated With Organ Failure in Severe COVID-19

Author

Rauch, Antoine, Dupont, Annabelle, Goutay, Julien, Caplan, Morgan, Staessens, Senna, Moussa, Mouhamed, Jeanpierre, Emmanuelle, Corseaux, Delphine, Lefevre, Guillaume, Lassalle, Fanny, Faure, Karine, Lambert, Marc, Duhamel, Alain, Labreuche, Julien, Garrigue, Delphine, De Meyer, Simon F., Staels, Bart, Van Belle, Eric, Vincent, Flavien, Kipnis, Eric, Lenting, Peter J., Poissy, Julien, and Susen, Sophie

Published
2020
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27. Association of Early Norepinephrine Administration With 24-Hour Mortality Among Patients With Blunt Trauma and Hemorrhagic Shock

Author

Gauss, Tobias, Richards, Justin, Tortù, Costanza, Ageron, François-Xavier, Hamada, Sophie, Josse, Julie, Husson, François, Harrois, Anatole, Scalea, Thomas, Vivant, Valentin, Meaudre, Eric, Morrison, Jonathan, Galvagno, Samue, Bouzat, Pierre, Albasini, François, Briot, Olivier, Chaboud, Laurent, Chateigner Coelsch, Sophie, Chaumat, Alexandre, Comlar, Thomas, Debas, Olivier, Debaty, Guillaume, Dupré-Nalet, Emmanuelle, Gay, Samuel, Ginestie, Edouard, Girard, Edouard, Grèze, Jules, Haesevoets, Marc, Hallain, Marie, Haller, Etienne, Hoareau, Christophe, Lanaspre, Bernard, Lespinasse, Safia, Levrat, Albrice, Mermillod-Blondin, Romain, Nicoud, Philippe, Rancurel, Elisabeth, Thouret, Jean-Marc, Vallenet, Claire, Vallot, Cécile, Zerr, Bénédicte, Abback, Paér-Sélim, Audibert, Gérard, Boutonnet, Mathieu, Clavier, Thomas, Cook, Fabrice, Eljamri, Mohamed, Floch, Thierry, Gaertner, Elisabeth, Garrigue, Delphine, Geeraerts, Thomas, Gette, Sebastien, Godier, Anne, Gosset, Pierre, Hanouz, Jean-Luc, Moyer, Jean-Denis, Langeron, Olivier, Leone, Marc, Pottecher, Julien, Portaz, Jonathan, Raux, Mathieu, Scotto, Marion, Willig, Mathieu, Hardy, Alexia, French Trauma Research Initiative, Albasini, F., Briot, O., Chaboud, L., Chateigner Coelsch, S., Chaumat, A., Comlar, T., Debas, O., Debaty, G., Dupré-Nalet, E., Gay, S., Ginestie, E., Girard, E., Grèze, J., Haesevoets, M., Hallain, M., Haller, E., Hoareau, C., Lanaspre, B., Lespinasse, S., Levrat, A., Mermillod-Blondin, R., Nicoud, P., Rancurel, E., Thouret, J.M., Vallenet, C., Vallot, C., Zerr, B., Abback, P.S., Audibert, G., Boutonnet, M., Clavier, T., Cook, F., Eljamri, M., Floch, T., Gaertner, E., Garrigue, D., Geeraerts, T., Gette, S., Godier, A., Gosset, P., Hanouz, J.L., Moyer, J.D., Langeron, O., Leone, M., Pottecher, J., Portaz, J., Raux, M., Scotto, M., Willig, M., Hardy, A., Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital d'Annecy, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Inria-SIC [Sophia Antipolis], Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Médecine de précision par intégration de données et inférence causale (PREMEDICAL), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut de Recherche Mathématique de Rennes (IRMAR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École normale supérieure - Rennes (ENS Rennes)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut Agro Rennes Angers, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Hôpital Bicêtre, Université Paris-Saclay, Hôpital d'Instruction des Armées Sainte Anne, Service de Santé des Armées, École du Val de Grâce (EVDG), CHU Grenoble, [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Hopital Saint-Jean-de-Maurienne, Laboratoire Charles Coulomb (L2C), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), and ANR-11-LABX-0020,LEBESGUE,Centre de Mathématiques Henri Lebesgue : fondements, interactions, applications et Formation(2011)

Subjects
Male, Norepinephrine, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], Humans, Hemorrhage, General Medicine, Middle Aged, Shock, Hemorrhagic, Wounds, Nonpenetrating, Hemorrhage/drug therapy, Norepinephrine/therapeutic use, Retrospective Studies, Shock, Hemorrhagic/drug therapy, Wounds, Nonpenetrating/complications, Wounds, Nonpenetrating/drug therapy
Abstract

ImportanceHemorrhagic shock is a common cause of preventable death after injury. Vasopressor administration for patients with blunt trauma and hemorrhagic shock is often discouraged.ObjectiveTo evaluate the association of early norepinephrine administration with 24-hour mortality among patients with blunt trauma and hemorrhagic shock.Design, Setting, and ParticipantsThis retrospective, multicenter, observational cohort study used data from 3 registries in the US and France on all consecutive patients with blunt trauma from January 1, 2013, to December 31, 2018. Patients were alive on admission with hemorrhagic shock, defined by prehospital or admission systolic blood pressure less than 100 mm Hg and evidence of hemorrhage (ie, prehospital or resuscitation room transfusion of packed red blood cells, receipt of emergency treatment for hemorrhage control, transfusion of >10 units of packed red blood cells in the first 24 hours, or death from hemorrhage). Blunt trauma was defined as any exposure to nonpenetrating kinetic energy, collision, or deceleration. Statistical analysis was performed from January 15, 2021, to February 22, 2022.ExposureContinuous administration of norepinephrine in the prehospital environment or resuscitation room prior to hemorrhage control, according to European guidelines.Main Outcomes and MeasuresThe primary outcome was 24-hour mortality, and the secondary outcome was in-hospital mortality. The average treatment effect (ATE) of early norepinephrine administration on 24-hour mortality was estimated according to the Rubin causal model. Inverse propensity score weighting and the doubly robust approach with 5 distinct analytical strategies were used to determine the ATE.ResultsA total of 52 568 patients were screened for inclusion, and 2164 patients (1508 men [70%]; mean [SD] age, 46 [19] years; median Injury Severity Score, 29 [IQR, 17-36]) presented with acute hemorrhage and were included. A total of 1497 patients (69.1%) required emergency hemorrhage control, 128 (5.9%) received a prehospital transfusion of packed red blood cells, and 543 (25.0%) received a massive transfusion. Norepinephrine was administered to 1498 patients (69.2%). The 24-hour mortality rate was 17.8% (385 of 2164), and the in-hospital mortality rate was 35.6% (770 of 2164). None of the 5 analytical strategies suggested any statistically significant association between norepinephrine administration and 24-hour mortality, with ATEs ranging from –4.6 (95% CI, –11.9 to 2.7) to 2.1 (95% CI, –2.1 to 6.3), or between norepinephrine administration and in-hospital mortality, with ATEs ranging from –1.3 (95% CI, –9.5 to 6.9) to 5.3 (95% CI, –2.1 to 12.8).Conclusions and RelevanceThe findings of this study suggest that early norepinephrine infusion was not associated with 24-hour or in-hospital mortality among patients with blunt trauma and hemorrhagic shock. Randomized clinical trials that study the effect of early norepinephrine administration among patients with trauma and hypotension are warranted to further assess whether norepinephrine is safe for patients with hemorrhagic shock.

Published
2022

29. Efficacy and Safety of Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion: The PROCOAG Randomized Clinical Trial.

Author

Bouzat, Pierre, Charbit, Jonathan, Abback, Paer-Selim, Huet-Garrigue, Delphine, Delhaye, Nathalie, Leone, Marc, Marcotte, Guillaume, David, Jean-Stéphane, Levrat, Albrice, Asehnoune, Karim, Pottecher, Julien, Duranteau, Jacques, Courvalin, Elie, Adolle, Anais, Sourd, Dimitri, Bosson, Jean-Luc, Riou, Bruno, Gauss, Tobias, and Payen, Jean-François

Subjects
RED blood cell transfusion, PLASMA products, BLOOD coagulation factor IX, PROTHROMBIN, SYSTOLIC blood pressure, BLOOD products
Abstract

Key Points: Question: Does 4-factor prothrombin complex concentrate (4F-PCC) reduce 24-hour blood product consumption in patients with trauma at risk of massive transfusion? Findings: In this superiority randomized trial involving 324 patients, there was no difference in total 24-hour blood product consumption among patients treated with 4F-PCC (12 U) vs placebo (11 U). More thromboembolic events occurred in the 4F-PCC group. Meaning: These findings do not support the administration of 4F-PCC in patients with trauma at risk of massive transfusion. Importance: Optimal transfusion strategies in traumatic hemorrhage are unknown. Reports suggest a beneficial effect of 4-factor prothrombin complex concentrate (4F-PCC) on blood product consumption. Objective: To investigate the efficacy and safety of 4F-PCC administration in patients at risk of massive transfusion. Design, Setting, and Participants: Double-blind, randomized, placebo-controlled superiority trial in 12 French designated level I trauma centers from December 29, 2017, to August 31, 2021, involving consecutive patients with trauma at risk of massive transfusion. Follow-up was completed on August 31, 2021. Interventions: Intravenous administration of 1 mL/kg of 4F-PCC (25 IU of factor IX/kg) vs 1 mL/kg of saline solution (placebo). Patients, investigators, and data analysts were blinded to treatment assignment. All patients received early ratio-based transfusion (packed red blood cells:fresh frozen plasma ratio of 1:1 to 2:1) and were treated according to European traumatic hemorrhage guidelines. Main Outcomes and Measures: The primary outcome was 24-hour all blood product consumption (efficacy); arterial or venous thromboembolic events were a secondary outcome (safety). Results: Of 4313 patients with the highest trauma level activation, 350 were eligible for emergency inclusion, 327 were randomized, and 324 were analyzed (164 in the 4F-PCC group and 160 in the placebo group). The median (IQR) age of participants was 39 (27-56) years, Injury Severity Score was 36 (26-50 [major trauma]), and admission blood lactate level was 4.6 (2.8-7.4) mmol/L; prehospital arterial systolic blood pressure was less than 90 mm Hg in 179 of 324 patients (59%), 233 patients (73%) were men, and 226 (69%) required expedient hemorrhage control. There was no statistically or clinically significant between-group difference in median (IQR) total 24-hour blood product consumption (12 [5-19] U in the 4F-PCC group vs 11 [6-19] U in the placebo group; absolute difference, 0.2 U [95% CI, −2.99 to 3.33]; P =.72). In the 4F-PCC group, 56 patients (35%) presented with at least 1 thromboembolic event vs 37 patients (24%) in the placebo group (absolute difference, 11% [95% CI, 1%-21%]; relative risk, 1.48 [95% CI, 1.04-2.10]; P =.03). Conclusions and Relevance: Among patients with trauma at risk of massive transfusion, there was no significant reduction of 24-hour blood product consumption after administration of 4F-PCC, but thromboembolic events were more common. These findings do not support systematic use of 4F-PCC in patients at risk of massive transfusion. Trial Registration: ClinicalTrials.gov Identifier: NCT03218722 This randomized clinical trial examines whether systematic 4-factor prothrombin complex concentrate administration combined with a ratio-based transfusion protocol is superior to ratio-based transfusion alone in reducing 24-hour total blood product consumption in patients at risk of massive transfusion. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Gunshot and stab wounds in France: descriptive study from a national trauma registry

Author

Descamps, Chloé, Hamada, Sophie Rym, Hanouz, Jean Luc, Vardon-Bounes, F., James, A., Garrigue, Delphine, Abback, P., Cardinale, Mickaël, Dubreuil, Guillaume, Chatelon, Jeanne, Cook, Fabrice, de Garambé, Nathalie, Ausset, Sylvain, Boutonnet, Mathieu, Meaudre-Desgouttes, E., Godier, Anne, Harrois, Anatole, Gauss, Tobias, Pottecher, Julien, Pirrachio, Romain, Gaertner, Elisabeth, Geeraerts, Thomas, Neuschwander, Arthur, Hôpital d'instruction des Armées Percy, Service de Santé des Armées, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Maison de Solenn [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Caen Normandie (UNICAEN), Normandie Université (NU), Hôpital Côte de Nacre [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU Toulouse [Toulouse], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), CHU Lille, Hôpital Beaujon [AP-HP], Hopital d'instruction des armées Sainte-Anne [Toulon] (HIA), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Service Anesthésie et Réanimation [Hôpital Nord - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], CHU Henri Mondor, Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), École du Val de Grâce (EVDG), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Dalian Maritime University, DMU, Traumabase registry is partly funded by the Regional Health Agency of Ile de France, France. Arthur James received fees from LFB (Laborzatoire Français du fractionnementet des Biotechnologies) for an educational project., French military health service Schools, Lyon-Bron, France, Val-de-Grâce Military Health Academy, Paris, France: Sylvain Ausset. Anesthesiology and Intensive Care Unit. Sainte Anne Military Teaching Hospital, Toulon, France: Eric Meaudre-Desgouttes. Université de Paris, Department of Anaesthesiology and Critical Care, AP-HP, Hôpital Européen Georges Pompidou, 25, rue Leblanc, 75015 Paris, France: Anne Godier. Department of Anesthesia and Critical Care, AP-HP, Bicêtre Hospital, Paris, France: Anatole Harrois. Department of Anaesthesiology and Intensive Care, AP-HP.Nord, Beaujon Hospital, DMU PARABOL, University of Paris, Clichy, France: Tobias Gauss. Anesthesia and Intensive Care Unit, University Hospital of Strasbourg, Strasbourg, France: Julien Pottecher. Université de Paris, Department of Anaesthesiology and Critical Care, AP-HP, Hôpital Européen Georges Pompidou, 25, rue Leblanc, 75015 Paris, France: Romain Pirrachio. Anesthesia and Intensive Care Unit, Hôpital Louis Pasteur de Colmar, Colmar, France: Elisabeth Gaertner. Department of Anesthesiology and Critical Care, Toulouse University Hospital, Toulouse, France: Thomas Geeraerts., Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and CHU Henri Mondor [Créteil]

Subjects
Adult, Registry, medicine.medical_specialty, Sports medicine, [SDV]Life Sciences [q-bio], Trauma registry, Wounds, Penetrating, Hospital mortality, Wounds, Stab, Critical Care and Intensive Care Medicine, Wounds, Nonpenetrating, Trauma, Stab, Trauma Centers, Medicine, Humans, Orthopedics and Sports Medicine, In patient, Registries, Retrospective Studies, business.industry, General surgery, Gunshot, Wound, Retrospective cohort study, medicine.disease, Severe trauma, Blunt trauma, Emergency Medicine, Surgery, Wounds, Gunshot, France, business, Penetrating trauma
Abstract

International audience; Purpose: Severe trauma is a major problem worldwide. In France, blunt trauma (BT) is predominant and few studies are available on penetrating trauma (PT). The purpose of this study was to perform a descriptive analysis of severe gunshot (GSW) and stab wounds (SW) in patients who were treated in French trauma centers. Methods: Retrospective study on prospectively collected data in a national trauma registry. All adult (> 15 years) trauma patients primarily admitted in 1 of the 17 trauma centers members of the Traumabase between January 2015 to December 2018 were included. Data from patients who had a PT were compared with those who had suffered a BT over the same period. Due to the known differences between GSW and SW, sub-group analyses on data from GSW, SW and BT were also performed. Results: 8128 patients were included. Twelve percent of the study group had a PT. The main mechanism of PT was SW (68.1%). Five hundred and eighty patients with PT (59.4%) required surgery within the first 24 h. Severe hemorrhage was more frequent in penetrating traumas (11.2% vs. 7.8% p < 0.001). Hospital mortality following PT was 8.9% vs 11% for blunt trauma (p = 0.047). Among PT the mortality after GSW was ten times higher than after SW (23.8% vs 2%). Conclusion: This work is the largest study to date that has specifically focused on GSW and SW in France, and will help improving knowledge in managing such patients in our country.

Published
2021

32. Prevention of venous thromboembolism and haemostasis monitoring in patients with COVID-19: Updated proposals (April 2021)

Author

Godon, Alexandre, primary, Tacquard, Charles Ambroise, additional, Mansour, Alexandre, additional, Garrigue, Delphine, additional, Nguyen, Philippe, additional, Lasne, Dominique, additional, Testa, Sophie, additional, Levy, Jerrold H., additional, Albaladejo, Pierre, additional, Gruel, Yves, additional, Susen, Sophie, additional, Godier, Anne, additional, Albaladejo, P., additional, Blais, N., additional, Bonhomme, F., additional, Borel-Derlon, A., additional, Cohen, A., additional, Collet, J.-P., additional, de Maistre, E., additional, Fontana, P., additional, Garrigue Huet, D., additional, Godier, A., additional, Gruel, Y., additional, Godon, A., additional, Ickx, B., additional, Laporte, S., additional, Lasne, D., additional, Llau, J., additional, Le Gal, G., additional, Lecompte, T., additional, Lessire, S., additional, Levy, J.H., additional, Longrois, D., additional, Madi-Jebara, S., additional, Mansour, A., additional, Mazighi, M., additional, Mismetti, P., additional, Morange, P.E., additional, Motte, S., additional, Mullier, F., additional, Nathan, N., additional, Nguyen, P., additional, Pernod, G., additional, Rosencher, N., additional, Roullet, S., additional, Roy, P.M., additional, Schlumberger, S., additional, Sié, P., additional, Steib, A., additional, Susen, S., additional, Tacquard, C.A., additional, Testa, S., additional, Vincentelli, A., additional, Zufferey, P., additional, Boissier, E, additional, Dumont, B, additional, James, C, additional, and Siguret, V., additional

Published
2021
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33. Specification and Evaluation of Plasticizer Migration Simulants for Human Blood Products: A Delphi Study

Author

Thelliez, Aurélie, primary, Hénard, Grégory, additional, Delorme, Bruno, additional, Chatellier, Sonia, additional, Danel, Cécile, additional, Ducoroy, Laurent, additional, Dupont, Annabelle, additional, Garrigue, Delphine, additional, Genay, Stéphanie, additional, Goossens, Jean-François, additional, Goossens, Laurence, additional, Havet, Coralie, additional, Hecq, Jean-Daniel, additional, Maeght, Caroline, additional, Mendel, Isabelle, additional, Najdovski, Tomé, additional, Odou, Pascal, additional, Saint-Lorant, Guillaume, additional, Ung, Alexandre, additional, Lecoeur, Marie, additional, and Décaudin, Bertrand, additional

Published
2021
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34. Impact of High-Dose Prophylactic Anticoagulation in Critically Ill Patients With COVID-19 Pneumonia

Author

Tacquard, Charles, primary, Mansour, Alexandre, additional, Godon, Alexandre, additional, Godet, Julien, additional, Poissy, Julien, additional, Garrigue, Delphine, additional, Kipnis, Eric, additional, Rym Hamada, Sophie, additional, Mertes, Paul Michel, additional, Steib, Annick, additional, Ulliel-Roche, Mathilde, additional, Bouhemad, Bélaïd, additional, Nguyen, Maxime, additional, Reizine, Florian, additional, Gouin-Thibault, Isabelle, additional, Besse, Marie Charlotte, additional, Collercandy, Nived, additional, Mankikian, Stefan, additional, Levy, Jerrold H., additional, Gruel, Yves, additional, Albaladejo, Pierre, additional, Susen, Sophie, additional, Godier, Anne, additional, Albaladejo, P., additional, Blais, N., additional, Bonhomme, F., additional, Borel-Derlon, A., additional, Cohen, A., additional, Collet, J.-P., additional, de Maistre, E., additional, Fontana, P., additional, Garrigue Huet, D., additional, Godier, A., additional, Gruel, Y., additional, Godon, A., additional, Ickx, B., additional, Laporte, S., additional, Lasne, D., additional, Llau, J., additional, Le Gal, G., additional, Lecompte, T., additional, Lessire, S., additional, Levy, J.H., additional, Longrois, D., additional, Madi-Jebara, S., additional, Mansour, A., additional, Mazighi, M., additional, Mismetti, P., additional, Morange, P.E., additional, Motte, S., additional, Mullier, F., additional, Nathan, N., additional, Nguyen, P., additional, Pernod, G., additional, Rosencher, N., additional, Roullet, S., additional, Roy, P.M., additional, Schlumberger, S., additional, Sié, P., additional, Steib, A., additional, Susen, S., additional, Tacquard, C.A., additional, Testa, S., additional, Vincentelli, A., additional, and Zufferey, P., additional

Published
2021
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35. Specification and Evaluation of Plasticizer Migration Simulants for Human Blood Products: A Delphi Study.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Département de pharmacie, Thelliez, Aurélie, Hénard, Grégory, Delorme, Bruno, Chatellier, Sonia, Danel, Cécile, Ducoroy, Laurent, Dupont, Annabelle, Garrigue, Delphine, Genay, Stéphanie, Goossens, Jean-François, Goossens, Laurence, Havet, Coralie, Hecq, Jean-Daniel, Maeght, Caroline, Mendel, Isabelle, Najdovski, Tomé, Odou, Pascal, Saint-Lorant, Guillaume, Ung, Alexandre, Lecoeur, Marie, Décaudin, Bertrand, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Département de pharmacie, Thelliez, Aurélie, Hénard, Grégory, Delorme, Bruno, Chatellier, Sonia, Danel, Cécile, Ducoroy, Laurent, Dupont, Annabelle, Garrigue, Delphine, Genay, Stéphanie, Goossens, Jean-François, Goossens, Laurence, Havet, Coralie, Hecq, Jean-Daniel, Maeght, Caroline, Mendel, Isabelle, Najdovski, Tomé, Odou, Pascal, Saint-Lorant, Guillaume, Ung, Alexandre, Lecoeur, Marie, and Décaudin, Bertrand

Abstract

Potentially toxic plasticizers are commonly added to polyvinyl chloride medical devices for transfusion in order to improve their flexibility and workability. As the plasticizers are not chemically bonded to the PVC, they can be released into labile blood products (LBPs) during storage. Ideally, LBPs would be used in laboratory studies of plasticizer migration from the medical device. However, short supply (i.e., limited stocks of human blood in collection centres) has prompted the development of specific simulants for each type of LBP in the evaluation of new transfusion devices. We performed a Delphi study with a multidisciplinary panel of 24 experts. In the first (qualitative) phase, the panel developed consensus definitions of the specification criteria to be met by each migration simulant. Next, we reviewed the literature on techniques for simulating the migration of plasticizers into LBPs. A questionnaire was elaborated and sent out to the experts, and the replies were synthesized in order to obtain a consensus. The qualitative study established specifications for each biological matrix (whole blood, red blood cell concentrate, plasma, and platelet concentrate) and defined the criteria required for a suitable LBP simulant. Ten criteria were suggested: physical and chemical characteristics, opacity, form, stability, composition, ability to mimic a particular clinical situation, ease and safety of use, a simulant-plastic interaction correlated with blood, and compatibility with analytical methods. The questionnaire data revealed a consensus on the use of natural products (such as pig's blood) to mimic the four LBPs. Opinions diverged with regard to synthetic products. However, an isotonic solution and a rheological property modifier were considered to be of value in the design of synthetic simulants. Consensus reached by the Delphi group could be used as a database for the development of simulants used to assess the migration of plasticizers from PVC bags into L

Published
2021

36. Additional file 3 of Early hyperoxemia is associated with lower adjusted mortality after severe trauma: results from a French registry

Author

Baekgaard, Josefine S., Paer-Selim Abback, Boubaya, Marouane, Jean-Denis Moyer, Garrigue, Delphine, Raux, Mathieu, Benoit Champigneulle, Dubreuil, Guillaume, Pottecher, Julien, Laitselart, Philippe, Laloum, Fleur, Bloch-Queyrat, Coralie, Adnet, Frédéric, and Paugam-Burtz, Catherine

Abstract

Additional file 3. Multivariate full model including factors used in propensity score.

Published
2020
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37. Additional file 2 of Early hyperoxemia is associated with lower adjusted mortality after severe trauma: results from a French registry

Author

Baekgaard, Josefine S., Paer-Selim Abback, Boubaya, Marouane, Jean-Denis Moyer, Garrigue, Delphine, Raux, Mathieu, Benoit Champigneulle, Dubreuil, Guillaume, Pottecher, Julien, Laitselart, Philippe, Laloum, Fleur, Bloch-Queyrat, Coralie, Adnet, Frédéric, and Paugam-Burtz, Catherine

Abstract

Additional file 2. Supplementary table on baseline characteristics for intubated vs spontaneously breathing patients.

Published
2020
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38. Early hyperoxemia is associated with lower adjusted mortality after severe trauma:results from a French registry

Author

Baekgaard, Josefine S., Abback, Paer-Selim, Boubaya, Marouane, Moyer, Jean-Denis, Garrigue, Delphine, Raux, Mathieu, Champigneulle, Benoit, Dubreuil, Guillaume, Pottecher, Julien, Laitselart, Philippe, Laloum, Fleur, Bloch-Queyrat, Coralie, Adnet, Frederic, Paugam-Burtz, Catherine, Pirracchio, Romain, Godier, Anne, Harrois, Anatole, Geeraerts, Thomas, Meaudre, Eric, Ausse, Sylvain, Gauss, Tobias, Meyer, Alain, Hamada, Sophie, Neuschwander, Arthur, Cook, Fabrice, Vinour, Helene, Hanouz, Jean Luc, Foucrier, Arnaud, Boutonnet, Mathieu, Raclot, Pascal, Arthur, James, Bruneau, Nathalie, Cotte, Jean, Leone, Marc, Audibert, Gerard, Steinmetz, Jacob, Rasmussen, Lars S., Baekgaard, Josefine S., Abback, Paer-Selim, Boubaya, Marouane, Moyer, Jean-Denis, Garrigue, Delphine, Raux, Mathieu, Champigneulle, Benoit, Dubreuil, Guillaume, Pottecher, Julien, Laitselart, Philippe, Laloum, Fleur, Bloch-Queyrat, Coralie, Adnet, Frederic, Paugam-Burtz, Catherine, Pirracchio, Romain, Godier, Anne, Harrois, Anatole, Geeraerts, Thomas, Meaudre, Eric, Ausse, Sylvain, Gauss, Tobias, Meyer, Alain, Hamada, Sophie, Neuschwander, Arthur, Cook, Fabrice, Vinour, Helene, Hanouz, Jean Luc, Foucrier, Arnaud, Boutonnet, Mathieu, Raclot, Pascal, Arthur, James, Bruneau, Nathalie, Cotte, Jean, Leone, Marc, Audibert, Gerard, Steinmetz, Jacob, and Rasmussen, Lars S.

Abstract

Background Hyperoxemia has been associated with increased mortality in critically ill patients, but little is known about its effect in trauma patients. The objective of this study was to assess the association between early hyperoxemia and in-hospital mortality after severe trauma. We hypothesized that a PaO2 >= 150 mmHg on admission was associated with increased in-hospital mortality. Methods Using data issued from a multicenter prospective trauma registry in France, we included trauma patients managed by the emergency medical services between May 2016 and March 2019 and admitted to a level I trauma center. Early hyperoxemia was defined as an arterial oxygen tension (PaO2) above 150 mmHg measured on hospital admission. In-hospital mortality was compared between normoxemic (150 > PaO2 >= 60 mmHg) and hyperoxemic patients using a propensity-score model with predetermined variables (gender, age, prehospital heart rate and systolic blood pressure, temperature, hemoglobin and arterial lactate, use of mechanical ventilation, presence of traumatic brain injury (TBI), initial Glasgow Coma Scale score, Injury Severity Score (ISS), American Society of Anesthesiologists physical health class > I, and presence of hemorrhagic shock). Results A total of 5912 patients were analyzed. The median age was 39 [26-55] years and 78% were male. More than half (53%) of the patients had an ISS above 15, and 32% had traumatic brain injury. On univariate analysis, the in-hospital mortality was higher in hyperoxemic patients compared to normoxemic patients (12% versus 9%,p < 0.0001). However, after propensity score matching, we found a significantly lower in-hospital mortality in hyperoxemic patients compared to normoxemic patients (OR 0.59 [0.50-0.70],p < 0.0001). Conclusion In this large observational study, early hyperoxemia in trauma patients was associated with reduced adjusted in-hospital mortality. This result contrasts the unadjusted in-hospital mortality as well

Published
2020

39. Study protocol for a multicentre, 2×2 factorial, randomised, controlled trial evaluating the interest of intravenous iron and tranexamic acid to reduce blood transfusion in hip fracture patients (the HiFIT study)

Author

Lasocki, Sigismond, primary, Loupec, Thibault, additional, Parot-Schinkel, Elsa, additional, Vielle, Bruno, additional, Danguy des Déserts, Marc, additional, Roquilly, Antoine, additional, Lahlou-Casulli, Maria, additional, Collange, Vincent, additional, Desebbe, Olivier, additional, Duchalais, Alexis, additional, Drugeon, Bertrand, additional, Bouzat, Pierre, additional, Garrigue, Delphine, additional, Mounet, Benjamin, additional, Hamard, Franck, additional, David, Jean-Stéphane, additional, Leger, Maxime, additional, and Rineau, Emmanuel, additional

Published
2021
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41. Clinico-Biological Features and Clonal Hematopoiesis in Patients with Severe COVID-19

Author

Duployez, Nicolas, primary, Demonchy, Jordane, additional, Berthon, Céline, additional, Goutay, Julien, additional, Caplan, Morgan, additional, Moreau, Anne-Sophie, additional, Bignon, Anne, additional, Marceau-Renaut, Alice, additional, Garrigue, Delphine, additional, Raczkiewicz, Imelda, additional, Geffroy, Sandrine, additional, Bucci, Maxime, additional, Alidjinou, Kazali, additional, Demaret, Julie, additional, Labalette, Myriam, additional, Brousseau, Thierry, additional, Dupont, Annabelle, additional, Rauch, Antoine, additional, Poissy, Julien, additional, Susen, Sophie, additional, Preudhomme, Claude, additional, and Quesnel, Bruno, additional

Published
2020
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42. Erratum to “Early management of severe pelvic injury (first 24 hours)” [Anaesth Crit Care Pain Med 38 (2019) 199–207. https://doi.org/10.1016/j.accpm.2018.12.003]

Author

Incagnoli, Pascal, primary, Puidupin, Alain, additional, Ausset, Sylvain, additional, Beregi, Jean-Paul, additional, Bessereau, Jacques, additional, Bobbia, Xavier, additional, Brun, Julien, additional, Brunel, Elodie, additional, Buléon, Clément, additional, Choukroun, Jacques, additional, Combes, Xavier, additional, David, Jean Stéphane, additional, Desfemmes, François-Régis, additional, Garrigue, Delphine, additional, Hanouz, Jean-Luc, additional, Plénier, Isabelle, additional, Rongieras, Fréderic, additional, Vivien, Benoit, additional, Gauss, Tobias, additional, Harrois, Anatole, additional, Bouzat, Pierre, additional, and Kipnis, Eric, additional

Published
2019
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43. Four-factor prothrombin complex concentrate to reduce allogenic blood product transfusion in patients with major trauma, the PROCOAG trial: study protocol for a randomized multicenter double-blind superiority study.

Author

Bouzat, Pierre, Bosson, Jean-Luc, David, Jean-Stéphane, Riou, Bruno, Duranteau, Jacques, Payen, Jean-François, on behalf of the PROCOAG study group, Levrat, Albrice, Abback, Paër-Selim, Garrigue, Delphine, Marcotte, Guillaume, Charbit, Jonathan, Asehnoune, Karim, Leone, Marc, Pottecher, Julien, and PROCOAG study group

Subjects
BLOOD products, BLOOD transfusion, PLASMA products, PROTHROMBIN, RESEARCH protocols, BLOOD coagulation factor IX
Abstract

Background: Optimal management of severe trauma patients with active hemorrhage relies on adequate initial resuscitation. Early administration of coagulation factors improves post-traumatic coagulation disorders, and four-factor prothrombin complex concentrate (PCC) might be useful in this context. Our main hypothesis is that four-factor PCC in addition to a massive transfusion protocol decreases blood product consumption at day 1 in severe trauma patients with major bleeding.Methods: This is a prospective, randomized, multicenter, double-blind, parallel, controlled superiority trial. Eligible patients are trauma patients with major bleeding admitted to a French level-I trauma center. Patients randomized in the treatment arm receive 1 mL/kg (25 IU/ml of Factor IX/Kg) four-factor PCC within 1-h post-admission while patients randomized in the controlled group receive 1 mL/kg of saline solution 0.9% as a placebo. Treatments are given as soon as possible using syringe pumps (120 mL/h). The primary endpoint is the amount of blood products transfused in the first 24 h post-admission (including red blood cells, frozen fresh plasma, and platelets). The secondary endpoints are the amount of each blood product transfused in the first 24 h, time to achieve prothrombin time ratio < 1.5, time to hemostasis, number of thrombo-embolic events at 28 days, mortality at 24 h and 28 days, number of intensive care unit-free days, number of ventilator-free days, number of hospital-free days within the first 28 days, hospitalization status at day 28, Glasgow outcome scale extended for patients with brain lesions on initial cerebral imaging, and cost of each strategy at days 8 and 28. Inclusions have started in December 2017 and are expected to be complete by June 2021.Discussion: If PCC reduces total blood consumption at day 1 after severe trauma, this therapy, in adjunction to a classic massive transfusion protocol, may be used empirically on admission in patients at risk of massive transfusion to enhance coagulation. Moreover, this treatment may decrease blood product-related complications and may improve clinical outcomes after post-traumatic hemorrhage.Trial Registration: ClinicalTrials.gov NCT03218722 . Registered on July 14, 2017. [ABSTRACT FROM AUTHOR]

Published
2021
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44. National early warning score to predict intensive care unit transfer and mortality in COVID‐19 in a French cohort.

Author

Pokeerbux, Mohammad Ryadh, Yelnik, Cécile M., Faure, Emmanuel, Drumez, Elodie, Bruandet, Amélie, Labreuche, Julien, Assaf, Ady, Goffard, Anne, Garabedian, Charles, Poissy, Julien, Desbordes, Jacques, Garrigue, Delphine, Scherpereel, Arnaud, Faure, Karine, and Lambert, Marc

Abstract

Background: No risk stratification tool has been validated in hospitalised patients with coronavirus disease 2019 (COVID‐19), despite a high rate of intensive care requirement and in‐hospital mortality. We aimed to determine whether the National Early Warning Score (NEWS) at admission can accurately predict in‐hospital mortality and ICU transfer. Methods: This was a retrospective cohort study from January 24 to April 16, 2020, at Lille University Hospital. All consecutive adult patients with laboratory‐confirmed COVID‐19 who were initially admitted to non‐ICU wards were included. The primary outcome was a composite criterion consisting of ICU transfer or in‐hospital mortality. We evaluated the prognostic performance of NEWS by calculating the area under (AUC) the receiver operating characteristic curve, the optimal threshold value of NEWS, and its association with the primary outcome. Results: Of the 202 COVID‐19 patients, the median age was 65 (interquartile range 52‐78), 38.6% were women and 136 had at least one comorbidity. The median NEWS was 4 (2‐6). A total of 65 patients were transferred to the ICU or died in the hospital. Compared with patients with favourable outcome, these patients were significantly older, had more comorbidities and higher NEWS. The AUC for NEWS was 0.68 (0.60‐0.77) and the best cutoff value was 6. Adjusted odds ratio for NEWS ≥ 6 as an independent predictor was 3.78 (1.94‐7.09). Conclusions: In hospitalised COVID‐19 patients, NEWS was an independent predictor of ICU transfer and in‐hospital death. In daily practice, NEWS ≥ 6 at admission may help to identify patients who are at risk to deteriorate. [ABSTRACT FROM AUTHOR]

Published
2021
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46. Gestion des agents antiplaquettaires en cas de procédure invasive non programmée ou d’hémorragie. Propositions du Groupe d’intérêt en hémostase périopératoire (GIHP) et du Groupe français d’études sur l’hémostase et la thrombose (GFHT) en collaboration avec la Société française d’anesthésie et de réanimation (SFAR)

Author

Godier, Anne, primary, Garrigue, Delphine, additional, Lasne, Dominique, additional, Fontana, Pierre, additional, Bonhomme, Fanny, additional, Collet, Jean-Philippe, additional, de Maistre, Emmanuel, additional, Ickx, Brigitte, additional, Gruel, Yves, additional, Mazighi, Mikael, additional, Nguyen, Philippe, additional, Vincentelli, André, additional, Albaladejo, Pierre, additional, Lecompte, Thomas, additional, Belisle, S., additional, Blais, N., additional, Borel-Derlon, A., additional, Borg, J.Y., additional, Bosson, J.-L., additional, Cohen, A., additional, Faraoni, D., additional, Garrigue Huet, D., additional, Guay, J., additional, Hardy, J.F., additional, Huet, Y., additional, Laporte, S., additional, Levy, J.H., additional, Llau, J., additional, Le Gal, G., additional, Lessire, S., additional, Longrois, D., additional, Madi-Jebara, S., additional, Marret, E., additional, Mas, J.L., additional, Meyer, G., additional, Mismetti, P., additional, Morange, P.E., additional, Motte, S., additional, Mullier, F., additional, Nathan, N., additional, Ozier, Y., additional, Pernod, G., additional, Rosencher, N., additional, Roullet, S., additional, Roy, P.M., additional, Samama, C.M., additional, Schlumberger, S., additional, Schved, J.F., additional, Sié, P., additional, Steib, A., additional, Susen, S., additional, van Belle, E., additional, van Der Linden, P., additional, and Zufferey, P., additional

Published
2019
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49. Position du GIHP sur les tests viscoélastiques : quelle place pour quelle indication en situation hémorragique ?

Author

Roullet, Stéphanie, primary, de Maistre, Emmanuel, additional, Ickx, Brigitte, additional, Blais, Normand, additional, Susen, Sophie, additional, Faraoni, David, additional, Garrigue, Delphine, additional, Bonhomme, Fanny, additional, Godier, Anne, additional, Lasne, Dominique, additional, Albaladejo, Pierre, additional, Belisle, Sylvain, additional, Borel-Derlon, Annie, additional, Borg, Jeanne-Yvonne, additional, Bosson, Jean-Luc, additional, Cohen, Ariel, additional, Collet, Jean-Philippe, additional, Fontana, Pierre, additional, Garrigue Huet, Delphine, additional, Gruel, Yves, additional, Guay, Joanne, additional, Hardy, Jean-François, additional, Huet, Yann, additional, Laporte, Silvy, additional, Levy, Jerrold H., additional, Llau, Juan, additional, Le Gal, Grégoire, additional, Lecompte, Thomas, additional, Lessire, Sarah, additional, Longrois, Dan, additional, Madi-Jebara, Samia, additional, Marret, Emmanuel, additional, Mas, Jean-Louis, additional, Mazighi, Mikael, additional, Mismetti, Patrick, additional, Morange, Pierre-Emmanuel, additional, Motte, Serge, additional, Mullier, François, additional, Nathan, Nathalie, additional, Nguyen, Philippe, additional, Ozier, Yves, additional, Pernod, Gilles, additional, Rosencher, Nadia, additional, Roullet, Stéphanie, additional, Roy, Pierre-Marie, additional, Samama, Charles Marc, additional, Schlumberger, Sylvie, additional, Schved, Jean-François, additional, Sié, Pierre, additional, Steib, Annick, additional, van Belle, Eric, additional, Van der Linden, Philippe, additional, Vincentelli, André, additional, and Zufferey, Paul, additional

Published
2018
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50. Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

Author

Habre, Walid, Disma, Nicola, Virag, Katalin, Becke, Karin, Hansen, Tom G., Joehr, Martin, Leva, Brigitte, Morton, Neil S., Vermeulen, Petronella M., Zielinska, Marzena, Boda, Krisztina, Veyckemans, Francis, Klimscha, Walter, Konecny, Regina, Luntzer, Robert, Morawk-Wintersperger, Ulrike, Neiger, Franz, Rustemeyer, Lydia, Breschan, Christian, Frey, Denise, Platzer, Manuela, Germann, Reinhard, Oeding, Joachim, Stoegermuller, Birgit, Ziegler, Bernhard, Brotatsch, Philipp, Gutmann, Anton, Mausser, Gerlinde, Messerer, Brigitte, Toller, Wolfgang, Vittinghoff, Maria, Zangl, Gregor, Seidel-Ahyai, Natascha, Hochhold, Christoph, Kroess, Ruth, Paal, Peter, Cnudde, Steven, Coucke, Patricia, Loveniers, Birgit, Mitchell, John, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Coppens, Marc, De Baerdemaeker, Luc, De Hert, Stefan, Heyse, Bjorn, Neckebroek, Martine, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Van Den Eynde, Nancy, Vanpeteghem, Caroline, Wyffels, Piet, Lalot, Michael, Lechat, Jean-Paul, Stevens, France, Casaer, Sari, De Groote, Francoise, De Pooter, Francoise, De Ville, Andree, Gerin, Marc, Magasich, Natalia, Torres, Cristel Sanchez, Van Deenen, Denise, Berghmans, Johan, Himpe, Dirk, Roofthooft, Eva, Joukes, Ellen, Smitz, Carine, Van Reeth, Veronique, Huygens, Christel, Lauweryns, Julie, De Smet, Karen, Najafi, Nadia, Poelaert, Jan, Van de Velde, Anne, Van Mossevelde, Veerle, Bekavac, Ivan, Butkovic, Diana, Litvic, Dubravka Heli, Soric, Ivana Kerovec, Maretic, Hrvoje, Moscatello, Djurdjica, Popovic, Ljiljana, Micic, Slobodan, Tus, Ivana Stuck, Fabris, Lada Kalagac, Simurina, Tatjana, Sulen, Nina, Kesi-Valpotic, Gordana, Djapic, Dajana, Zurek, Jiri, Jureckova, Lucie, Mackova, Iveta, Skacel, Monika, Weinlichova, Stanislava, Divak, Jan, Frelich, Michal, Urbanec, Rene, Biskupova, Vera, Mixa, Vladimir, Pavlickova, Jana, Afshari, Arash, Bottger, Morten, Ellekvist, Marguerite B., Johansen, Mathias, Madsen, Birgitte Ingeborg, Nilsson, Jens Christian, Schousboe, Birgitte M. B., Clausen, Nicola G., Steen, Nick Phaff, Ilmoja, Mari-Liis, Tonise, Virge, Karjagin, Juri, Kikas, Reet, Isohanni, Mika, Lyly, Anniina, Takala, Annika, Happo, Johanna, Kiviluoma, Kai, Martikainen, Kati, Aantaa, Riku, Manner, Tuula, Vilo, Sanna, Amory, Catherine, Ludot, Hugues, Lambotte, Patricia, Busche, Rene, Jacqmarcq, Olivier, Lejus, Corinne, Corouge, Julien, Erb, Christian, Garrigue, Delphine, Gillet, Patricia, Laffargue, Anne, Lambelin, Veronique, Le Freche, Helene, Peresbota, Daliana, Richart, Pierre, Berton, Jerome, Chapotte, Catherine, Colbus, Laurent, Lehousse, Thierry, Monrigal, Jean, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Batoz, Helene, Bordes, Maryline, Didier, Anne, Hamonic, Yann, Lagarde, Sylvaine, Nouette-Gaulain, Karine, Semjen, Francois, Zaghet, Brigitte, Dekens, Jacky, Delcuze, Axelle, Dupont, Herve, Legrand, Aurelien, Raffoflandreur, Celine, Audren, Noemie, Camus, Blandine, Cartal, Marielle, Chazelet, Chantal, Davin, Isabelle, Guillier, Marion, Desjeux, Luc, Larcher, Claire, Grein, Elodie, Leclercq, Mickeal, Levitchi, Roxana, Rosu, Lilica, Simon, Dominique, Zang, Aurelien, Migeon, Anne, Gagey, Anne-Charlotte, Bourdaud, Nathalie, Carre, Anne-Charlotte, Duflo, Frederic, Riche, Jean-Claude, Robert, Philippe, Druot, Emilie, Maupain, Olivier, Orliaguet, Gilles, Sabau, Lucie, Taright, Hanna, Uhrig, Lynn, Verchere-Montmayeur, Juliette, Debrabant, Lise, Pilla, Clotaire, Podvin, Alexandre, Roth, Benjamin, Dahmani, Souhayl, Julien-Marsollier, Florence, Sabourdin, Nada, Alexandri, Bogdan, Brezac, Gilles, de la Briere, Francois, Hayem, Catherine, Lhubat, Elizabeth, Mission, Jean Paul, Remond, Charlotte, Dadure, Christophe, Maniora, Maud, Marie, Anais, Pirat, Philippe, Saour, Anne-Charlotte, Sola, Chrystelle, Ecoffey, Claude, Wodey, Eric, Adam, Christian, Standl, Thomas, Schindler, Ehrenfried, Yamamoto, Tomohiro, Brackhahn, Michael, Eich, Christoph Bernhard, Guericke, Holger, Kindermann, Petra, Laschat, Michael, Schink, Cornel, Wappler, Frank, Hoehne, Claudia, Skordou, Natalia, Ulrici, Johanna, Jetzek-Zader, Martin, Kienbaum, Peter, Meyer-Treschan, Tanja, Picker, Olaf, Schaefer, Maximilian S., Mielke, Golo, Baethge, Sabine, Ramminger, Axel, Bauer, Martin, Bollinger, Matthias, Hinz, Jose, Quintel, Michael, Russo, Sebastian G., Bauer, Michael, Geil, Dfominik, Kortgen, Andreas, Preussler, Niels-Peter, Hofmann, Ulrich, Raber, Manfred, Reindl, Doris, Oppenrieder, Karin, Schierlinger, Bettina, Roth, Jens, Funk, Wolfgang, Fischer, Thomas, Gernoth, Christian, Wiefelsputz, Christina, Volger, Hauke, Zederer, Nicole, Diers, Anja, Huber, Matthias, Schorer, Clemens, Weyland, Andreas, Schwarzkopf, Konrad, Grau, Catharina, Roth, Winfried, Holy, Rolf, Mader, Thomas, Peter, Laura, Supthut, Hauke, Kuehhirt, Thomas, Milde, Alexander, Fiedler, Fritz, Isselhorst, Carsten, Grundmann, Ulrich, Pattar, Alexander, Reinert, Jennifer, Ehm, Birgit, Fritzsche, Katrin, Gaebler, Ralf, Meybohm, Patrick, Hein, Maximilian, Guzman, Ines, Jokinen, Johanna, Kranke, Peter, Goebel, Ulrich, Harris, Sarah, Eisner, Christoph, Ochsenreiter, Miriam, Schoeler, Michael, Thil, Elke, Ellerkmann, Richard, Hoeft, Andreas, Neumann, Claudia, Weber, Stefan, Keilhauer, Julia, Kloessing, Jan, Schramm, Michael, Trieschmann, Uwe, Knauss, Kristina, Sinner, Barbara, Steinmann, Johannes, Koessler, Herbert, Kalliardou, Evagelia, Malisiova, Anna, Tsiotou, Adelais, Chloropoulou, Pelagia, Chrysi, Mpratzou, Iordanidou, Despoina, Ntavlis, Merkourios, Rarosi, Ferenc, Boda, Krisztina B., Guerin, Christilynn, Irwin, Janice, Magner, Claire, Nakhjavani, Solmaz, O'Hare, Brendan, Galvin, Deborah, Jamil, Yosry, Lesmes, Carlos, Barak, Yuri, Fisher, Haran, Kachko, Ludmyla, Katz, Jacob, Kirilov, Dmitry, Levinzon, Michael, Manevich, Yair, Nekrasov, Konstantin, Peled, Elia, Sanko, Elena, Schmain, Dmitri, Sheinkin, Olga, Simhi, Eliahu, Tarabikin, Alex, Trabkin, Evelina, Yagudaev, Irena, Zeitlin, Yelena, Zunser, Igor, Habre, Walid, Disma, Nicola, Virag, Katalin, Becke, Karin, Hansen, Tom G., Joehr, Martin, Leva, Brigitte, Morton, Neil S., Vermeulen, Petronella M., Zielinska, Marzena, Boda, Krisztina, Veyckemans, Francis, Klimscha, Walter, Konecny, Regina, Luntzer, Robert, Morawk-Wintersperger, Ulrike, Neiger, Franz, Rustemeyer, Lydia, Breschan, Christian, Frey, Denise, Platzer, Manuela, Germann, Reinhard, Oeding, Joachim, Stoegermuller, Birgit, Ziegler, Bernhard, Brotatsch, Philipp, Gutmann, Anton, Mausser, Gerlinde, Messerer, Brigitte, Toller, Wolfgang, Vittinghoff, Maria, Zangl, Gregor, Seidel-Ahyai, Natascha, Hochhold, Christoph, Kroess, Ruth, Paal, Peter, Cnudde, Steven, Coucke, Patricia, Loveniers, Birgit, Mitchell, John, Kahn, David, Pirotte, Thierry, Pregardien, Caroline, Coppens, Marc, De Baerdemaeker, Luc, De Hert, Stefan, Heyse, Bjorn, Neckebroek, Martine, Parashchanka, Aliaksandra, Van Limmen, Jurgen, Van Den Eynde, Nancy, Vanpeteghem, Caroline, Wyffels, Piet, Lalot, Michael, Lechat, Jean-Paul, Stevens, France, Casaer, Sari, De Groote, Francoise, De Pooter, Francoise, De Ville, Andree, Gerin, Marc, Magasich, Natalia, Torres, Cristel Sanchez, Van Deenen, Denise, Berghmans, Johan, Himpe, Dirk, Roofthooft, Eva, Joukes, Ellen, Smitz, Carine, Van Reeth, Veronique, Huygens, Christel, Lauweryns, Julie, De Smet, Karen, Najafi, Nadia, Poelaert, Jan, Van de Velde, Anne, Van Mossevelde, Veerle, Bekavac, Ivan, Butkovic, Diana, Litvic, Dubravka Heli, Soric, Ivana Kerovec, Maretic, Hrvoje, Moscatello, Djurdjica, Popovic, Ljiljana, Micic, Slobodan, Tus, Ivana Stuck, Fabris, Lada Kalagac, Simurina, Tatjana, Sulen, Nina, Kesi-Valpotic, Gordana, Djapic, Dajana, Zurek, Jiri, Jureckova, Lucie, Mackova, Iveta, Skacel, Monika, Weinlichova, Stanislava, Divak, Jan, Frelich, Michal, Urbanec, Rene, Biskupova, Vera, Mixa, Vladimir, Pavlickova, Jana, Afshari, Arash, Bottger, Morten, Ellekvist, Marguerite B., Johansen, Mathias, Madsen, Birgitte Ingeborg, Nilsson, Jens Christian, Schousboe, Birgitte M. B., Clausen, Nicola G., Steen, Nick Phaff, Ilmoja, Mari-Liis, Tonise, Virge, Karjagin, Juri, Kikas, Reet, Isohanni, Mika, Lyly, Anniina, Takala, Annika, Happo, Johanna, Kiviluoma, Kai, Martikainen, Kati, Aantaa, Riku, Manner, Tuula, Vilo, Sanna, Amory, Catherine, Ludot, Hugues, Lambotte, Patricia, Busche, Rene, Jacqmarcq, Olivier, Lejus, Corinne, Corouge, Julien, Erb, Christian, Garrigue, Delphine, Gillet, Patricia, Laffargue, Anne, Lambelin, Veronique, Le Freche, Helene, Peresbota, Daliana, Richart, Pierre, Berton, Jerome, Chapotte, Catherine, Colbus, Laurent, Lehousse, Thierry, Monrigal, Jean, Baujard, Catherine, Roulleau, Philippe, Staiti, Giuseppe, Batoz, Helene, Bordes, Maryline, Didier, Anne, Hamonic, Yann, Lagarde, Sylvaine, Nouette-Gaulain, Karine, Semjen, Francois, Zaghet, Brigitte, Dekens, Jacky, Delcuze, Axelle, Dupont, Herve, Legrand, Aurelien, Raffoflandreur, Celine, Audren, Noemie, Camus, Blandine, Cartal, Marielle, Chazelet, Chantal, Davin, Isabelle, Guillier, Marion, Desjeux, Luc, Larcher, Claire, Grein, Elodie, Leclercq, Mickeal, Levitchi, Roxana, Rosu, Lilica, Simon, Dominique, Zang, Aurelien, Migeon, Anne, Gagey, Anne-Charlotte, Bourdaud, Nathalie, Carre, Anne-Charlotte, Duflo, Frederic, Riche, Jean-Claude, Robert, Philippe, Druot, Emilie, Maupain, Olivier, Orliaguet, Gilles, Sabau, Lucie, Taright, Hanna, Uhrig, Lynn, Verchere-Montmayeur, Juliette, Debrabant, Lise, Pilla, Clotaire, Podvin, Alexandre, Roth, Benjamin, Dahmani, Souhayl, Julien-Marsollier, Florence, Sabourdin, Nada, Alexandri, Bogdan, Brezac, Gilles, de la Briere, Francois, Hayem, Catherine, Lhubat, Elizabeth, Mission, Jean Paul, Remond, Charlotte, Dadure, Christophe, Maniora, Maud, Marie, Anais, Pirat, Philippe, Saour, Anne-Charlotte, Sola, Chrystelle, Ecoffey, Claude, Wodey, Eric, Adam, Christian, Standl, Thomas, Schindler, Ehrenfried, Yamamoto, Tomohiro, Brackhahn, Michael, Eich, Christoph Bernhard, Guericke, Holger, Kindermann, Petra, Laschat, Michael, Schink, Cornel, Wappler, Frank, Hoehne, Claudia, Skordou, Natalia, Ulrici, Johanna, Jetzek-Zader, Martin, Kienbaum, Peter, Meyer-Treschan, Tanja, Picker, Olaf, Schaefer, Maximilian S., Mielke, Golo, Baethge, Sabine, Ramminger, Axel, Bauer, Martin, Bollinger, Matthias, Hinz, Jose, Quintel, Michael, Russo, Sebastian G., Bauer, Michael, Geil, Dfominik, Kortgen, Andreas, Preussler, Niels-Peter, Hofmann, Ulrich, Raber, Manfred, Reindl, Doris, Oppenrieder, Karin, Schierlinger, Bettina, Roth, Jens, Funk, Wolfgang, Fischer, Thomas, Gernoth, Christian, Wiefelsputz, Christina, Volger, Hauke, Zederer, Nicole, Diers, Anja, Huber, Matthias, Schorer, Clemens, Weyland, Andreas, Schwarzkopf, Konrad, Grau, Catharina, Roth, Winfried, Holy, Rolf, Mader, Thomas, Peter, Laura, Supthut, Hauke, Kuehhirt, Thomas, Milde, Alexander, Fiedler, Fritz, Isselhorst, Carsten, Grundmann, Ulrich, Pattar, Alexander, Reinert, Jennifer, Ehm, Birgit, Fritzsche, Katrin, Gaebler, Ralf, Meybohm, Patrick, Hein, Maximilian, Guzman, Ines, Jokinen, Johanna, Kranke, Peter, Goebel, Ulrich, Harris, Sarah, Eisner, Christoph, Ochsenreiter, Miriam, Schoeler, Michael, Thil, Elke, Ellerkmann, Richard, Hoeft, Andreas, Neumann, Claudia, Weber, Stefan, Keilhauer, Julia, Kloessing, Jan, Schramm, Michael, Trieschmann, Uwe, Knauss, Kristina, Sinner, Barbara, Steinmann, Johannes, Koessler, Herbert, Kalliardou, Evagelia, Malisiova, Anna, Tsiotou, Adelais, Chloropoulou, Pelagia, Chrysi, Mpratzou, Iordanidou, Despoina, Ntavlis, Merkourios, Rarosi, Ferenc, Boda, Krisztina B., Guerin, Christilynn, Irwin, Janice, Magner, Claire, Nakhjavani, Solmaz, O'Hare, Brendan, Galvin, Deborah, Jamil, Yosry, Lesmes, Carlos, Barak, Yuri, Fisher, Haran, Kachko, Ludmyla, Katz, Jacob, Kirilov, Dmitry, Levinzon, Michael, Manevich, Yair, Nekrasov, Konstantin, Peled, Elia, Sanko, Elena, Schmain, Dmitri, Sheinkin, Olga, Simhi, Eliahu, Tarabikin, Alex, Trabkin, Evelina, Yagudaev, Irena, Zeitlin, Yelena, and Zunser, Igor

Abstract

Background Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors. Methods The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760. Findings Between April 1, 2014, and Jan 31, 2015, 31 127 anaesthetic procedures in 30 874 children with a mean age of 6.35 years (SD 4.50) were included. The incidence of perioperative severe critical events was 5.2% (95% CI 5.0-5.5) with an incidence of respiratory critical events of 3.1% (2.9-3.3). Cardiovascular instability occurred in 1.9% (1.7-2.1), with an immediate poor outcome in 5.4% (3.7-7.5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10 000. This was independent of type of anaesthesia. Age (relative risk 0.88, 95% CI 0.86-0.90; p<0.0001), medical history, and physical condition (1.60, 1.40-1.82; p<0.0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0.99, 0.981-0.997; p<0.0048 for respiratory critical events, and 0.98, 0.97-0.99; p=0.0039 for

Published
2017

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