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43 results on '"Garrett, Laura D."'

1. Contributors

Author

Amsellem, Pierre M., primary, Argyle, David J., additional, Avery, Anne C., additional, Bacon, Nicholas J., additional, Bailey, Dennis B., additional, Bergman, Philip J., additional, Biller, Barbara, additional, Bonnett, Brenda N., additional, Boston, Sarah E., additional, Burton, Jenna H., additional, Christensen, Neil I., additional, Clifford, Craig A., additional, Culp, William T.N., additional, Dow, Steven, additional, Ehrhart, Nicole P., additional, Fan, Timothy M., additional, Farese, James P., additional, Flesner, Brian K., additional, Friedrichs, Kristen R., additional, Fulkerson, Christopher M., additional, Garrett, Laura D., additional, Giancristofaro, Nicole, additional, Gordon, Ira K., additional, Gustafson, Daniel L., additional, Guth, Amanda, additional, Hauck, Marlene L., additional, Henry, Carolyn J., additional, Kamstock, Debra A., additional, Kent, Michael S., additional, Khanna, Chand, additional, Kim, Jong Hyuk, additional, Knapp, Deborah W., additional, Lana, Susan E., additional, LaRue, Susan M., additional, Lascelles, B. Duncan X., additional, Lawrence, Jessica A., additional, LeBlanc, Amy K., additional, Liptak, Julius M., additional, London, Cheryl A., additional, Lunn, Katharine F., additional, Macy, Dennis W., additional, Magee, Kara, additional, de Mello Souza, Carlos H., additional, Meneses, Constanza, additional, Miller, Paul E., additional, Modiano, Jaime F., additional, Moore, Peter F., additional, Mullin, Christine, additional, Mutsaers, Anthony J., additional, Nolan, Michael W., additional, Nykamp, Stephanie, additional, Oblak, Michelle L., additional, Page, Rodney L., additional, Pancotto, Theresa E., additional, Paoloni, Melissa C., additional, Pinkerton, Marie, additional, Powers, Barbara E., additional, Randall, Elissa, additional, Reagan, Jennifer K., additional, Rebhun, Robert B., additional, Robinson, Narda G., additional, Rossmeisl, John H., additional, Ruple, Audrey, additional, Russell, Duncan S., additional, Saba, Corey F., additional, Selmic, Laura E., additional, Selting, Kim A., additional, Shaw, Jane R., additional, Skinner, Owen T., additional, Skorupski, Katherine A., additional, Sorenmo, Karin U., additional, Stern, Joshua A., additional, Teixeira, Leandro B.C., additional, Thamm, Douglas H., additional, Turek, Michelle M., additional, Vail, David M., additional, Wakshlag, Joseph, additional, Withrow, Stephen J., additional, Woods, J. Paul, additional, Worley, Deanna R., additional, Young, Karen M., additional, and Zappulli, Valentina, additional

Published
2020
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4. Vaginal swab cytology as a diagnostic tool for neoplasia of the lower urinary tract in 5 dogs

Author

Kao, Sunny, Barger, Anne, and Garrett, Laura D.

Subjects
Scientific
Abstract

Urothelial carcinoma (UC), or transitional cell carcinoma, is the most common canine urothelial malignancy in dogs. Females are predisposed and provide a challenge for diagnostic tumor sampling. The objectives of this study were to investigate the use and tolerability of vaginal swab cytology for UC diagnosis. Five dogs were identified with non-diagnostic urine sediment cytology and UC diagnosed on vaginal cytology with confirmation by another means. All patients tolerated the vaginal swab with minimal restraint. This study confirms the potential of vaginal swab cytology as a simple, inexpensive, and well-tolerated means for lower urinary tract UC diagnosis in female dogs. Key clinical message: Vaginal swab cytology is a non-invasive, low-cost method of obtaining a sample for cytological assessment for UC.

Published
2022

6. Spectrum of care: more than treatment options

Author

Brown, Carolyn R., primary, Garrett, Laura D., additional, Gilles, William K., additional, Houlihan, Kendall E., additional, McCobb, Emily, additional, Pailler, Sharon, additional, Putnam, Holly, additional, Scarlett, Jennifer L., additional, Treglia, Linda, additional, Watson, Brittany, additional, and Wietsma, Henry T., additional

Published
2021
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8. Contributors

Author

Argyle, David J., primary, Avery, Anne C., additional, Bergman, Philip J., additional, Bonnett, Brenda N., additional, Butler, Lesley M., additional, Clifford, Craig A., additional, Culp, William T.N., additional, Dewey, Curtis W., additional, Dow, Steven, additional, Dubielzig, Richard R., additional, Ehrhart, E.J., additional, Ehrhart, Nicole P., additional, Fan, Timothy M., additional, Farese, James P., additional, Forrest, Lisa J., additional, Friedrichs, Kristen R., additional, Garrett, Laura D., additional, Goldschmidt, Michael H., additional, Gordon, Ira K., additional, Gustafson, Daniel L., additional, Guth, Amanda M., additional, Hauck, Marlene L., additional, Henry, Carolyn J., additional, Kamstock, Debra A., additional, Kent, Michael S., additional, Khanna, Chand, additional, Kisseberth, William C., additional, Knapp, Deborah W., additional, Kraft, Susan L., additional, Lana, Susan E., additional, LaRue, Susan M., additional, Lascelles, B. Duncan X., additional, Lawrence, Jessica A., additional, Liptak, Julius M., additional, London, Cheryl A., additional, Lunn, Katharine F., additional, Macy, Dennis W., additional, McEntee, Margaret C., additional, McMillan, Sarah K., additional, Miller, Paul E., additional, Modiano, Jaime F., additional, Moore, Peter F., additional, Mutsaers, Anthony J., additional, Olver, Christine, additional, Page, Rodney L., additional, Paoloni, Melissa C., additional, Pinkerton, Marie E., additional, Powers, Barbara E., additional, Rebhun, Robert B., additional, Robinson, Narda G., additional, Ryan, Stewart D., additional, Saba, Corey F., additional, Selting, Kim A., additional, Shaw, Jane R., additional, Skorupski, Katherine A., additional, Sorenmo, Karin U., additional, de Mello Souza, Carlos Henrique, additional, Thamm, Douglas H., additional, Turek, Michelle M., additional, Vail, David M., additional, Wakshlag, Joseph J., additional, Withrow, Stephen J., additional, Woods, J. Paul, additional, Worley, Deanna R., additional, and Young, Karen M., additional

Published
2013
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12. Finding and treating oral melanoma, squamous cell carcinoma, and fibrosarcoma in dogs: the three malignancies most likely to occur in dogs' mouths can have devastating local or metastatic effects if not identified and treated quickly. Review how surgery--in conjunction with radiation, chemotherapy, or vaccination--may increase your patients' survival times

Author

Coyle, Virginia J. and Garrett, Laura D.

Subjects
Cancer vaccines -- Health aspects, Immunotherapy -- Health aspects, Mouth cancer -- Risk factors, Mouth cancer -- Diagnosis, Mouth cancer -- Care and treatment, Mouth cancer -- Prevention, Dogs -- Diseases, Dogs -- Risk factors, Dogs -- Diagnosis, Dogs -- Care and treatment, Dogs -- Prevention, Biological sciences, Health
Abstract

The oral cavity is a common site I for malignant tumors, accounting for 5% to 7% of all canine cancers. (1) The most common oral malignancies in dogs are melanoma [...]

Published
2009

13. Feline oral squamous cell carcinoma: an overview: these fast-growing, painful tumors are not uncommon in cats, and few affected patients survive long-term. But a patient's chances can improve if you identify and address the disease early

Author

Marretta, Jennifer J., Garrett, Laura D., and Marretta, Sandra Manfra

Subjects
Cats -- Diseases, Cats -- Care and treatment, Mouth cancer -- Risk factors, Mouth cancer -- Care and treatment, Biological sciences, Health
Abstract

The oral cavity is a common site for neoplasia in cats, accounting for about 10% of all feline tumors. (1) The most common malignant oral tumor in cats is squamous [...]

Published
2007

17. Long-term survival in six cats with mediastinal cysts.

Author

Camero, Corrine M, Neumann, Zachary L, and Garrett, Laura D

Abstract

Case series summary: Mediastinal cysts were diagnosed as incidental findings in six cats evaluated for non-thoracic disease, including staging for historical bladder leiomyosarcoma, flea dermatitis and hairballs, and hyperthyroidism. Radiographically, the cysts appeared as soft tissue opacities cranial to the heart. Ultrasound revealed the masses to be thin-walled, single lumen, anechoic, fluid-filled structures. One cat also had thoracic and abdominal CT performed for cancer staging; the CT revealed a well-defined, fluid-attenuating mass without peripheral contrast enhancement in the cranial mediastinum. Fine-needle aspiration confirmed acellular fluid consistent with a cyst in five cases; in one case the cyst ruptured during aspiration and no fluid was obtained. Post-aspiration, all masses were no longer visible with ultrasound or radiographs. No treatment was recommended for the cysts. Long-term follow-up (2–9 years post-diagnosis) was available in all six cats. The cysts recurred in five cats but were never associated with clinical signs. Relevance and novel information: Mediastinal cysts are an important benign differential for cranial mediastinal masses in cats. Treatment for the cysts does not appear to be indicated. This series also includes the first CT description of this clinical entity. [ABSTRACT FROM AUTHOR]

Published
2019
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21. How to break bad news to clients: More than any other specialty, oncology involves difficult discussions with clients. For smoother conversations under emotional circumstances, follow this advice

Author

Garrett, Laura D.

Subjects
Cancer -- Diagnosis, Physician and patient -- Management, Company business management, Biological sciences, Health
Abstract

Studies in human medicine show that patients repeatedly mention the importance of the way conversations regarding bad news are handled. Key factors that influence the way veterinary clients adapt to [...]

Published
2013

22. Maintenance therapy with toceranib following doxorubicin-based chemotherapy for canine splenic hemangiosarcoma

Author

Gardner, Heather L., primary, London, Cheryl A., additional, Portela, Roberta A., additional, Nguyen, Sandra, additional, Rosenberg, Mona P., additional, Klein, Mary K., additional, Clifford, Craig, additional, Thamm, Douglas H., additional, Vail, David M., additional, Bergman, Phil, additional, Crawford-Jakubiak, Martin, additional, Henry, Carolyn, additional, Locke, Jennifer, additional, and Garrett, Laura D., additional

Published
2015
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23. Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1 in healthy dogs

Author

Lucas, Pamela W., Schmit, Joanna M., Peterson, Quinn P., West, Diana C., Hsu, Danny C., Novotny, Chris J., Dirikolu, Levent, Deorge, Daniel R., Garrett, Laura D., Hergenrother, Paul J., and Fan, Timothy M.

Subjects
Cell Extracts, Time Factors, endocrine system diseases, Dose-Response Relationship, Drug, Caspase 3, Hydrazones, food and beverages, Enzyme Activators, Antineoplastic Agents, Apoptosis, Article, Piperazines, Enzyme Activation, Small Molecule Libraries, Dogs, Health, Cell Line, Tumor, Animals, Humans
Abstract

PAC-1 is a preferential small molecule activator of procaspase-3 and has potential to become a novel and effective anticancer agent. The rational development of PAC-1 for translational oncologic applications would be advanced by coupling relevant in vitro cytotoxicity studies with pharmacokinetic investigations conducted in large mammalian models possessing similar metabolism and physiology as people. In the present study, we investigated whether concentrations and exposure durations of PAC-1 that induce cytotoxicity in lymphoma cell lines in vitro can be achievable in healthy dogs through a constant rate infusion (CRI) intravenous delivery strategy. Time- and dose-dependent procaspase-3 activation by PAC-1 with subsequent cytotoxicity was determined in a panel of B-cell lymphoma cells in vitro. The pharmacokinetics of PAC-1 administered orally or intravenously was studied in 6 healthy dogs using a crossover design. The feasibility of maintaining steady state plasma concentration of PAC-1 for 24 or 48 hours that paralleled in vitro cytotoxic concentrations was investigated in 4 healthy dogs. In vitro, PAC-1 induced apoptosis in lymphoma cell lines in a time- and dose-dependent manner. The oral bioavailability of PAC-1 was relatively low and highly variable (17.8 ± 9.5%). The achievement and maintenance of predicted PAC-1 cytotoxic concentrations in normal dogs was safely attained via intravenous CRI lasting for 24 or 48 hours in duration. Using the dog as a large mammalian model, PAC-1 can be safely administered as an intravenous CRI while achieving predicted in vitro cytotoxic concentrations.

Published
2010

24. Canine mast cell tumors: diagnosis, treatment, and prognosis

Author

Garrett,Laura D and Garrett,Laura D

Abstract

Laura D Garrett Department of Veterinary Clinical Medicine, University of Illinois College of Veterinary Medicine, Urbana, IL, USA Abstract: Mast cell tumors (MCTs) are the most common malignant skin cancer in dogs, and significant variability exists in their biological behavior. Most MCTs are cured with appropriate local therapy, but a subset shows malignant behavior with the potential to spread to lymph nodes, liver, spleen, and other areas and to thus become a systemic cancer. Because of this variable behavior, it is difficult to predict how any individual tumor is going to behave. The variability thus creates uncertainty in deciding what a particular dog's prognosis is, whether staging tests to assess for metastasis are needed, and even what treatments will be necessary for best outcome. In addition to controversies over the potential for development of systemic disease, or diffuse metastasis, controversies also exist over what treatment is needed to best attain local control of these tumors. This article will briefly discuss the diagnosis of MCTs in dogs and will summarize the literature in regards to the controversial topics surrounding the more aggressive form of this disease, with recommendations made based on published studies. Keywords: mitotic index, mastocytosis, tyrosine kinase inhibitor, histologic grade

Published
2014

26. Evaluation of factors associated with second remission in dogs with lymphoma undergoing retreatment with a cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy protocol: 95 cases (2000–2007)

Author

Flory, Andrea B., primary, Rassnick, Kenneth M., additional, Erb, Hollis N., additional, Garrett, Laura D., additional, Northrup, Nicole C., additional, Selting, Kim A., additional, Phillips, Brenda S., additional, Locke, Jennifer E., additional, and Chretin, John D., additional

Published
2011
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28. Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs

Author

Lucas, Pamela W., primary, Schmit, Joanna M., additional, Peterson, Quinn P., additional, West, Diana C., additional, Hsu, Danny C., additional, Novotny, Chris J., additional, Dirikolu, Levent, additional, Churchwell, Mona I., additional, Doerge, Daniel R., additional, Garrett, Laura D., additional, Hergenrother, Paul J., additional, and Fan, Timothy M., additional

Published
2010
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37. Drs. Garrett and Coyle respond.

Author

Garrett, Laura D. and Coyle, Virginia J.

Subjects
*LETTERS to the editor, *SQUAMOUS cell carcinoma
Abstract

A response by Laura D. Garret and Virginia J. Coyle to a letter to the editor about their article "Finding and Treating Verbal Melonoma, Squamous Cell Carcinoma, and Fibrosarcoma in Dogs" in the June 2009 issue is presented.

Published
2009

38. Small Animal Clinical Diagnosis by Laboratory Methods.

Author

Garrett, Laura D.

Subjects
*VETERINARY medicine, *NONFICTION
Abstract

The article reviews the book "Small Animal Clinical Diagnosis by Laboratory Methods, 5th edition," by Michael D. Willard and Harold Tvedten.

Published
2012

39. Blackwell's Five-Minute Veterinary Consult: Laboratory Tests and Diagnostic Procedures—Canine & Feline (Five-Minute Veterinary Consult Series).

Author

Garrett, Laura D.

Subjects
*VETERINARY clinical pathology, *NONFICTION
Abstract

The article reviews the book "Blackwell's Five-Minute Veterinary Consult: Laboratory Tests and Diagnostic Procedures: Canine & Feline," by Shelly L. Vaden, Joyce S. Knoll, Francis W. K. Smith Jr., and Larry P. Tilley, part of "Five-Minute Veterinary Consult" book series.

Published
2010

40. Evaluation of a bladder tumor antigen test as a screening test for transitional cell carcinoma of the lower urinary tract in dogs.

Author

Henry, Carolyn J., Tyler, Jeff W., McEntee, Margaret C., Stokol, Tracy, Rogers, Kenita S., Chun, Ruthanne, Garrett, Laura D., McCaw, Dudley L., Higginbotham, Mary Lynn, Flessland, Karen A., and Stokes, Pam Koffend

Subjects
*BLADDER, *TUMOR antigens, *CANCER, *URINARY organs, *DOGS, *VETERINARY medicine
Abstract

Provides information on a study that evaluated the veterinary version of the bladder tumor antigen test as a screening test for transitional cell carcinoma of the lower urinary tract of dogs. Methodology of the study; Results and discussion on the study; Conclusions.

Published
2003
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41. Vaginal swab cytology as a diagnostic tool for neoplasia of the lower urinary tract in 5 dogs.

Author

Kao S, Barger A, and Garrett LD

Subjects
Female, Dogs, Animals, Cytological Techniques veterinary, Carcinoma, Transitional Cell diagnosis, Carcinoma, Transitional Cell veterinary, Urinary Bladder Neoplasms veterinary, Urinary Tract, Dog Diseases diagnosis
Abstract

Urothelial carcinoma (UC), or transitional cell carcinoma, is the most common canine urothelial malignancy in dogs. Females are predisposed and provide a challenge for diagnostic tumor sampling. The objectives of this study were to investigate the use and tolerability of vaginal swab cytology for UC diagnosis. Five dogs were identified with non-diagnostic urine sediment cytology and UC diagnosed on vaginal cytology with confirmation by another means. All patients tolerated the vaginal swab with minimal restraint. This study confirms the potential of vaginal swab cytology as a simple, inexpensive, and well-tolerated means for lower urinary tract UC diagnosis in female dogs. Key clinical message: Vaginal swab cytology is a non-invasive, low-cost method of obtaining a sample for cytological assessment for UC., (Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.)

Published
2022

42. Canine mast cell tumors: diagnosis, treatment, and prognosis.

Author

Garrett LD

Abstract

Mast cell tumors (MCTs) are the most common malignant skin cancer in dogs, and significant variability exists in their biological behavior. Most MCTs are cured with appropriate local therapy, but a subset shows malignant behavior with the potential to spread to lymph nodes, liver, spleen, and other areas and to thus become a systemic cancer. Because of this variable behavior, it is difficult to predict how any individual tumor is going to behave. The variability thus creates uncertainty in deciding what a particular dog's prognosis is, whether staging tests to assess for metastasis are needed, and even what treatments will be necessary for best outcome. In addition to controversies over the potential for development of systemic disease, or diffuse metastasis, controversies also exist over what treatment is needed to best attain local control of these tumors. This article will briefly discuss the diagnosis of MCTs in dogs and will summarize the literature in regards to the controversial topics surrounding the more aggressive form of this disease, with recommendations made based on published studies., Competing Interests: The author is a member of a consulting panel of veterinarians for Zoetis and their product Palladia® (toceranib phosphate)., (© 2014 Garrett.)

Published
2014
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43. Predictors of response to radioiodine therapy in hyperthyroid cats.

Author

Chun R, Garrett LD, Sargeant J, Sherman A, and Hoskinson JJ

Subjects
Animals, Antithyroid Agents administration & dosage, Cat Diseases diagnostic imaging, Cats, Drug Administration Schedule, Hyperthyroidism radiotherapy, Iodine Radioisotopes administration & dosage, Methimazole administration & dosage, Predictive Value of Tests, Premedication, Radionuclide Imaging veterinary, Records veterinary, Retrospective Studies, Thyroxine blood, Treatment Outcome, Antithyroid Agents therapeutic use, Cat Diseases radiotherapy, Hyperthyroidism veterinary, Iodine Radioisotopes therapeutic use, Methimazole therapeutic use, Regression Analysis
Abstract

The objective of this retrospective study was to evaluate hyperthyroid cats for pretreatment factors that would predict response to radioiodine therapy. Hyperthyroidism was diagnosed in 193 cats based on elevated serum thyroxine levels and/or elevated thyroid to salivary gland ratios on thyroid scintigraphy. All cats were treated with an intravenous bolus of 4 mCi of radioiodine and follow-up serum thyroxine levels were evaluated at 1 week and 1, 3, 6, and 12 months post-therapy. There was a significant relationship between pretreatment thyroxine values and post-treatment thyroxine values at all of the follow-up time points (p < 0.001). There was also a relationship between thyroid to salivary gland technetium scan ratio results and serum thyroxine values at pretreatment and at 1 week post-treatment (p = 0.02, 0.005, respectively). A greater scan ratio was associated with higher thyroxine levels at these time points, but not at 1, 3, 6 or 12 months post-therapy. Ninety-eight cats pretreated with methimazole were analyzed for the effect of this drug on response to therapy. Methimazole was discontinued > or = 5 days before radioiodine therapy in 58 cats and < 5 days in 31 cats, in 9 cats the number of days off methimazole was unknown. There was no difference in response to radioiodine based upon when methimazole was discontinued (p = 0.70).

Published
2002
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