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9. A Contribution to the Harmonization of Non-targeted NMR Methods for Data-Driven Food Authenticity Assessment

Author

Gallo, V, Ragone, R, Musio, B, Todisco, S, Rizzuti, A, Mastrorilli, P, Pontrelli, S, Intini, N, Scapicchio, P, Triggiani, M, Pascazio, A, Cobas, C, Mari, S, Garino, C, Arlorio, M, Acquotti, D, Airoldi, C, Arnesano, F, Assfalg, M, Barison, A, Benevelli, F, Borioni, A, Cagliani, L, Casadei, L, Marincola, F, Colson, K, Consonni, R, Costantino, G, Cremonini, M, Davalli, S, Duarte, I, Guyader, S, Hamon, E, Hegmanns, M, Lamanna, R, Longobardi, F, Mallamace, D, Mammi, S, Markus, M, Menezes, L, Milone, S, Molero-Vilchez, D, Mucci, A, Napoli, C, Rossi, M, Saez-Barajas, E, Savorani, F, Schievano, E, Sciubba, F, Sobolev, A, Takis, P, Thomas, F, Villa-Valverde, P, Latronico, M, Gallo V., Ragone R., Musio B., Todisco S., Rizzuti A., Mastrorilli P., Pontrelli S., Intini N., Scapicchio P., Triggiani M., Pascazio A., Cobas C., Mari S., Garino C., Arlorio M., Acquotti D., Airoldi C., Arnesano F., Assfalg M., Barison A., Benevelli F., Borioni A., Cagliani L. R., Casadei L., Marincola F. C., Colson K., Consonni R., Costantino G., Cremonini M. A., Davalli S., Duarte I., Guyader S., Hamon E., Hegmanns M., Lamanna R., Longobardi F., Mallamace D., Mammi S., Markus M., Menezes L. R. A., Milone S., Molero-Vilchez D., Mucci A., Napoli C., Rossi M. C., Saez-Barajas E., Savorani F., Schievano E., Sciubba F., Sobolev A., Takis P. G., Thomas F., Villa-Valverde P., Latronico M., Gallo, V, Ragone, R, Musio, B, Todisco, S, Rizzuti, A, Mastrorilli, P, Pontrelli, S, Intini, N, Scapicchio, P, Triggiani, M, Pascazio, A, Cobas, C, Mari, S, Garino, C, Arlorio, M, Acquotti, D, Airoldi, C, Arnesano, F, Assfalg, M, Barison, A, Benevelli, F, Borioni, A, Cagliani, L, Casadei, L, Marincola, F, Colson, K, Consonni, R, Costantino, G, Cremonini, M, Davalli, S, Duarte, I, Guyader, S, Hamon, E, Hegmanns, M, Lamanna, R, Longobardi, F, Mallamace, D, Mammi, S, Markus, M, Menezes, L, Milone, S, Molero-Vilchez, D, Mucci, A, Napoli, C, Rossi, M, Saez-Barajas, E, Savorani, F, Schievano, E, Sciubba, F, Sobolev, A, Takis, P, Thomas, F, Villa-Valverde, P, Latronico, M, Gallo V., Ragone R., Musio B., Todisco S., Rizzuti A., Mastrorilli P., Pontrelli S., Intini N., Scapicchio P., Triggiani M., Pascazio A., Cobas C., Mari S., Garino C., Arlorio M., Acquotti D., Airoldi C., Arnesano F., Assfalg M., Barison A., Benevelli F., Borioni A., Cagliani L. R., Casadei L., Marincola F. C., Colson K., Consonni R., Costantino G., Cremonini M. A., Davalli S., Duarte I., Guyader S., Hamon E., Hegmanns M., Lamanna R., Longobardi F., Mallamace D., Mammi S., Markus M., Menezes L. R. A., Milone S., Molero-Vilchez D., Mucci A., Napoli C., Rossi M. C., Saez-Barajas E., Savorani F., Schievano E., Sciubba F., Sobolev A., Takis P. G., Thomas F., Villa-Valverde P., and Latronico M.

Abstract

Spectroscopic non-targeted methods are gaining ever-growing importance in quality control and authenticity assessment of food products because of their strong potential for identification of specific features of the products by data-driven classifiers. One of the factors hampering the diffusion of spectroscopic non-targeted methods and data-driven classifiers is the lack of harmonized guidelines for their development and validation. In particular, to date, neither conditions to directly compare spectra recorded by different spectrometers nor studies demonstrating the statistical equivalence of the spectra are available. Among the spectroscopic analytical techniques suitable for the development of non-targeted methods, nuclear magnetic resonance (NMR) offers the unique opportunity to generate statistically equivalent signals. In this paper, the feasibility of NMR spectroscopy to generate statistically equivalent NMR signals from a number of different spectrometers was demonstrated for complex mixtures (aqueous extracts of wheat and flour) by organizing an inter-laboratory comparison involving 36 NMR spectrometers. Univariate statistics along with multivariate analysis were exploited to establish unbiased criteria for assessing the statistical equivalence of the NMR signals. The aspects affecting the signal equivalence were investigated, and possible solutions to reduce the extent of the human error were proposed and applied with satisfactory results. This study furnishes the scientific community with an appropriate and easy procedure to validate non-targeted NMR methods and provides error values to be used as a reference for future studies.

Published
2020

10. High-Luminosity Large Hadron Collider (HL-LHC): Technical design report

Author

Aberle, O., Béjar Alonso, I, Brüning, O, Fessia, P, Rossi, L, Tavian, L, Zerlauth, M, Adorisio, C., Adraktas, A., Ady, M., Albertone, J., Alberty, L., Alcaide Leon, M., Alekou, A., Alesini, D., Ferreira, B. Almeida, Lopez, P. Alvarez, Ambrosio, G., Andreu Munoz, P., Anerella, M., Angal-Kalinin, D., Antoniou, F., Apollinari, G., Apollonio, A., Appleby, R., Arduini, G., Alonso, B. Arias, Artoos, K., Atieh, S., Auchmann, B., Badin, V., Baer, T., Baffari, D., Baglin, V., Bajko, M., Ball, A., Ballarino, A., Bally, S., Bampton, T., Banfi, D., Barlow, R., Barnes, M., Barranco, J., Barthelemy, L., Bartmann, W., Bartosik, H., Barzi, E., Battistin, M., Baudrenghien, P., Alonso, I. Bejar, Belomestnykh, S., Benoit, A., Ben-Zvi, I., Bertarelli, A., Bertolasi, S., Bertone, C., Bertran, B., Bestmann, P., Biancacci, N., Bignami, A., Bliss, N., Boccard, C., Body, Y., Borburgh, J., Bordini, B., Borralho, F., Bossert, R., Bottura, L., Boucherie, A., Bozzi, R., Bracco, C., Bravin, E., Bregliozzi, G., Brett, D., Broche, A., Brodzinski, K., Broggi, F., Bruce, R., Brugger, M., Brüning, O., Buffat, X., Burkhardt, H., Burnet, J., Burov, A., Burt, G., Cabezas, R., Cai, Y., Calaga, R., Calatroni, S., Capatina, O., Capelli, T., Cardon, P., Carlier, E., Carra, F., Carvalho, A., Carver, L.R., Caspers, F., Cattenoz, G., Cerutti, F., Chancé, A., Rodrigues, M. Chastre, Chemli, S., Cheng, D., Chiggiato, P., Chlachidze, G., Claudet, S., Coello De Portugal, JM., Collazos, C., Corso, J., Costa Machado, S., Costa Pinto, P., Coulinge, E., Crouch, M., Cruikshank, P., Cruz Alaniz, E., Czech, M., Dahlerup-Petersen, K., Dalena, B., Daniluk, G., Danzeca, S., Day, H., De Carvalho Saraiva, J., De Luca, D., De Maria, R., De Rijk, G., De Silva, S., Dehning, B., Delayen, J., Deliege, Q., Delille, B., Delsaux, F., Denz, R., Devred, A., Dexter, A., Di Girolamo, B., Dietderich, D., Dilly, J.W., Doherty, A., Dos Santos, N., Drago, A., D.Drskovic, Ramos, D. Duarte, Ducimetière, L., Efthymiopoulos, I., Einsweiler, K., Esposito, L., Esteban Muller, J., Evrard, S., Fabbricatore, P., Farinon, S., Fartoukh, S., Faus-Golfe, A., Favre, G., Felice, H., Feral, B., Ferlin, G., Ferracin, P., Ferrari, A., Ferreira, L., Fessia, P., Ficcadenti, L., Fiotakis, S., Fiscarelli, L., Fitterer, M., Fleiter, J., Foffano, G., Fol, E., Folch, R., Foraz, K., Foussat, A., Frankl, M., Frasciello, O., Fraser, M., Menendez, P. Freijedo, Fuchs, J-F., Furuseth, S., Gaddi, A., Gallilee, M., Gallo, A., Alia, R. Garcia, Gavela, H. Garcia, Matos, J. Garcia, Garcia Morales, H., Valdivieso, A. Garcia-Tabares, Garino, C., Garion, C., Gascon, J., Gasnier, Ch., Gentini, L., Gentsos, C., Ghosh, A., Giacomel, L., Hernandez, K. Gibran, Gibson, S., Ginburg, C., Giordano, F., Giovannozzi, M., Goddard, B., Gomes, P., Gonzalez De La Aleja Cabana, M., Goudket, P., Gousiou, E., Gradassi, P., Costa, A. Granadeiro, Grand-Clément, L., Grillot, S., Guillaume, JC., Guinchard, M., Hagen, P., Hakulinen, T., Hall, B., Hansen, J., Heredia Garcia, N., Herr, W., Herty, A., Hill, C., Hofer, M., Höfle, W., Holzer, B., Hopkins, S., Hrivnak, J., Iadarola, G., Infantino, A., Bermudez, S. Izquierdo, Jakobsen, S., Jebramcik, M.A., Jenninger, B., Jensen, E., Jones, M., Jones, R., Jones, T., Jowett, J., Juchno, M., Julie, C., Junginger, T., Kain, V., Kaltchev, D., Karastathis, N., Kardasopoulos, P., Karppinen, M., Keintzel, J., Kersevan, R., Killing, F., Kirby, G., Korostelev, M., Kos, N., Kostoglou, S., Kozsar, I., Krasnov, A., Krave, S., Krzempek, L., Kuder, N., Kurtulus, A., Kwee-Hinzmann, R., Lackner, F., Lamont, M., Lamure, A.L., m, L. Lari, Lazzaroni, M., Le Garrec, M., Lechner, A., Lefevre, T., Leuxe, R., Li, K., Li, Z., Lindner, R., Lindstrom, B., Lingwood, C., Löffler, C., Lopez, C., Lopez-Hernandez, LA., Losito, R., Maciariello, F., Macintosh, P., Maclean, E.H., Macpherson, A., Maesen, P., Magnier, C., Durand, H. Mainaud, Malina, L., Manfredi, M., Marcellini, F., Marchevsky, M., Maridor, S., Marinaro, G., Marinov, K., Markiewicz, T., Marsili, A., Martinez Urioz, P., Martino, M., Masi, A., Mastoridis, T., Mattelaer, P., May, A., Mazet, J., Mcilwraith, S., McIntosh, E., Medina Medrano, L., Mejica Rodriguez, A., Mendes, M., Menendez, P., Mensi, M., Mereghetti, A., Mergelkuhl, D., Mertens, T., Mether, L., Métral, E., Migliorati, M., Milanese, A., Minginette, P., Missiaen, D., Mitsuhashi, T., Modena, M., Mokhov, N., Molson, J., Monneret, E., Montesinos, E., Moron-Ballester, R., Morrone, M., Mostacci, A., Mounet, N., Moyret, P., Muffat, P., Muratori, B., Muttoni, Y., Nakamoto, T., Navarro-Tapia, M., Neupert, H., Nevay, L., Nicol, T., Nilsson, E., Ninin, P., Nobrega, A., Noels, C., Nolan, E., Nosochkov, Y., Nuiry, FX., Oberli, L., Ogitsu, T., Ohmi, K., Olave R., Oliveira, J., Orlandi, Ph., Ortega, P., Osborne, J., Otto, T., Palumbo, L., Papadopoulou, S., Papaphilippou, Y., Paraschou, K., Parente, C., Paret, S., Park, H., Parma, V., Pasquino, Ch., Patapenka, A., Patnaik, L., Pattalwar, S., Payet, J., Pechaud, G., Pellegrini, D., Pepinster, P., Perez, J., Espinos, J. Perez, Marcone, A. Perillo, Perin, A., Perini, P., Persson, T.H.B., Peterson, T., Pieloni, T., Pigny, G., Pinheiro de Sousa, J.P., Pirotte, O., Plassard, F., Pojer, M., Pontercorvo, L., Poyet, A., Prelipcean, D., Prin, H., Principe, R., Pugnat, T., Qiang, J., Quaranta, E., Rafique, H., Rakhno, I., Duarte, D. Ramos, Ratti, A., Ravaioli, E., Raymond, M., Redaelli, S., Renaglia, T., Ricci, D., Riddone, G., Rifflet, J., Rigutto, E., Rijoff, T., Rinaldesi, R., Riu Martinez, O., Rivkin, L., Rodriguez Mateos, F., Roesler, S., Romera Ramirez, I., Rossi, A., Rossi, L., Rude, V., Rumolo, G., Rutkovksi, J., Sabate Gilarte, M., Sabbi, G., Sahner, T., Salemme, R., Salvant, B., Galan, F. Sanchez, Santamaria Garcia, A., Santillana, I., Santini, C., Santos, O., Diaz, P. Santos, Sasaki, K., Savary, F., Sbrizzi, A., Schaumann, M., Scheuerlein, C., Schmalzle, J., Schmickler, H., Schmidt, R., Schoerling, D., Segreti, M., Serluca, M., Serrano, J., Sestak, J., Shaposhnikova, E., Shatilov, D., Siemko, A., Sisti, M., Sitko, M., Skarita, J., Skordis, E., Skoufaris, K., Skripka, G., Smekens, D., Sobiech, Z., Sosin, M., Sorbio, M., Soubelet, F., Spataro, B., Spiezia, G., Stancari, G., Staterao, M., Steckert, J., Steele, G., Sterbini, G., Struik, M., Sugano, M., Szeberenyi, A., Taborelli, M., Tambasco, C., Rego, R. Tavares, Tavian, L., Teissandier, B., Templeton, N., Therasse, M., Thiesen, H., Thomas, E., Toader, A., Todesco, E., Tomás, R., Toral, F., Torres-Sanchez, R., Trad, G., Triantafyllou, N., Tropin, I., Tsinganis, A., Tuckamantel, J., Uythoven, J., Valishev, A., Van Der Veken, F., Van Weelderen, R., Vande Craen, A., Vazquez De Prada, B., Velotti, F., Verdu Andres, S., Verweij, A., Shetty, N. Vittal, Vlachoudis, V., Volpini, G., Wagner, U., Wanderer, P., Wang, M., Wang, X., Wanzenberg, R., Wegscheider, A., Weisz, S., Welsch, C., Wendt, M., Wenninger, J., Weterings, W., White, S., Widuch, K., Will, A., Willering, G., Wollmann, D., Wolski, A., Wozniak, J., Wu, Q., Xiao, B., Xiao, L., Xu, Q., Yakovlev, Y., Yammine, S., Yang, Y., Yu, M., Zacharov, I., Zagorodnova, O., Zannini, C., Zanoni, C., Zerlauth, M., Zimmermann, F., Zlobin, A., Zobov, M., and Zurbano Fernandez, I.

Subjects
Accelerators and Storage Rings
Abstract

The Large Hadron Collider (LHC) is one of the largest scientific instruments ever built. Since opening up anew energy frontier for exploration in 2010, it has gathered a global user community of about 9000 scientists working in fundamental particle physics and the physics of hadronic matter at extreme temperature and density. To sustain and extend its discovery potential, the LHC will need a major upgrade in the 2020s. This will increase its instantaneous luminosity (rate of collisions) by a factor of five beyond the original design valueand the integrated luminosity (totalnumber of collisions) by a factor ten. The LHC is already a highly complexand exquisitely optimised machine so this upgrade must be carefully conceived and will require new infrastructures(underground and on surface)and over a decade to implement. The new configuration, known as High Luminosity LHC (HL-LHC), relies on a number of key innovations that push accelerator technology beyond its present limits. Among these are cutting-edge 11–12Tesla superconducting magnets, compact superconducting cavities for beam rotation with ultra-precise phase control, new technology and physical processes for beam collimation and 100 metre-long high-power superconducting links with negligible energy dissipation, all of which required several years of dedicated R&D; effort on a global international level. The present document describes the technologies and components that will be used to realise the projectand is intended to serve as the basis for the detailed engineering design of the HL-LHC.

Published
2020

12. Flavin Bioorthogonal Photocatalysis Towards Platinum Substrates

Author

Gurruchaga-Pereda, J, Martinez-Martinez, V, Rezabal, E, Lopez, X, Garino, C, Mancin, F, Cortajarena, AL, and Salassa, L.

Abstract

Catalytic reactions that use metal complexes as substrates, rather than catalysts, are nearly unknown. We recently demonstrated that certain flavins (FLs) are potent redox photocatalysts capable of converting PtIV anticancer prodrug complexes into PtII drugs in the biological environment. Herein, we investigate the mechanism of these artificial photocatalytic reactions employing four different free flavins, namely riboflavin (Rf), flavin mononucleotide (FMN), tetra-O-acetyl riboflavin (TARF) and lumiflavin (Lf), and the flavoprotein miniSOG (mini Singlet Oxygen Generator) together with a panel of PtIV substrates conveniently selected. NMR, steady-state and time-resolved optical spectroscopy studies highlight that light activation of FLs in the presence of NADH as electron donor (pH 7–7.5) eventually leads to the generation of the reduced FLH– species which catalyzes the PtIV-to- PtII conversion with turnover frequency (TOF) values ranging between 1.3 and 30 min–1, and turnover number (TON) values reaching 500. Comparable catalytic efficiency is also found for reactions performed in cell culture medium. Density functional theory suggests that activation via reduction of the PtIV substrates may be influenced by H-bonding interactions between the FL catalyst and the metal substrate and confirm that both the isoalloxazine and ribityl moieties of the FLs determine the catalytic efficiency of the process. The FMN-containing miniSOG is a less effective catalyst (TOFs < 5.6 min–1) since the formation of the doubly reduced FMNH– competes with an electron transfer reaction with the protein matrix which quenches the FMN triplet-excited state to give a singly-reduced FMN•–.

Published
2019

13. Untargeted High Resolution Mass Spectrometry for discriminating authentic saffron

Author

Monaci L., De Angelis E., Pilolli R., Godula M., Hollosi L., Garino C., and Arlorio M.

Subjects
LC High Resolution MS, Untargeted anaysis, DART-High Resolution MS, saffron authenticity
Abstract

Saffron is a valuable and highly appreciated spice derived from the dried red stigmas of the flowers of the cultivated plant Crocus sativus L. It is commonly used as a coloring and flavouring agent in food preparation. In addition, it is a good source of flavonoids, proteins, sugars, vitamins, amino acids, mineral matter, gums, and other chemical compounds that make it a health promoting spice. To produce saffron spice, harvested stigmas are submitted to a mild food processing peculiar of the region of production thus it could be considered a traditional product, which aroma and chemical composition strictly depend on the geographic location of production. Due to its high costs of production, saffron is one of the most expensive spice commercialized across the world, and often susceptible of adulteration. Different plant-derived adulterants have been discovered, and the most frequently involve cut and/or dyed Carthamus tinctorius L. petals and Curcuma longa L. powdered rhizomes (Kanti et al., 2011). Several analytical methods have been reported in literature for the detection of plant adulterants in saffron samples based on different techniques (e.g. Maggi et al., 2011, Zalacain et al., 2005, Tarantilis et al., 2004, Zougagh et al., 2005) although official methods (ISO 3632-1; ISO 3632-2) exist. Very recently, high-performance liquid chromatography coupled to high resolution mass spectrometry (HRMS) was successfully proposed for saffron authentication/traceability according to the geographical origin based on untargeted metabolic fingerprinting (Rubert et al., 2016). In this work, we investigated two HRMS based approaches one using ESI ionization coupled to LC separation and the other based on DART ionization before HRMS detection to assess saffron authenticity by an untargeted metabolic approach. Pure saffron samples and saffron spiked with different amounts of Carthamus and Curcuma adulterants were extracted with a mix of ethanol and water to extract the majority of metabolites and final MS fingerprints obtained were used for authenticity assessment and/or adulteration detection. The produced spectra were then processed via the commercial software Compound Discoverer v.2.1 SP1 (Thermo Fisher Scientific). The detection and grouping of the unknown compounds by setting a mass accuracy

Published
2018

17. Evaluation of the impact of sequential microwave/ultrasound processing on the IgE binding properties of Pru p 3 in treated peach juice

Author

Garino, C., Zitelli, F., Travaglia, F., Coïsson, J. D., Cravotto, Giancarlo, Van Ree, R., and Arlorio, Marco

Subjects
Chromatography, Chemistry, business.industry, Food Handling, Ultrasound, Proteolytic enzymes, General Chemistry, Antigens, Plant, Immunoglobulin E, Ige binding, Sound, Food Preservation, Fruit, Food science, Prunus, General Agricultural and Biological Sciences, Peach juice, business, Carrier Proteins, Microwaves, Plant lipid transfer proteins, Incubation, Food Hypersensitivity, Plant Proteins
Abstract

Peach lipid transfer protein (LTP) can cause severe allergic reactions to peach-allergic patients. It belongs to the nonspecific LTPs family, a class of proteins extremely resistant both to proteolytic digestion and to high temperatures. Food processing can either drop or increase the allergenicity, depending on the process and on the food. As far as peach-derived products (pulp, juice) are concerned, it has been previously shown how thermal treatment performed in an autoclave does not decrease LTP allergenicity. In this work, it was attempted to investigate whether sequential microwave and ultrasound processing could affect the allergenicity of peach juice. Incubation with specific anti-Pru p 3 serum showed how treating peach peel with microwave at 140 °C and with ultrasound does not eliminate Pru p 3 IgE binding properties. The application of MW/US protocol on peach pulp appeared to be insufficient for the reduction of IgE binding to Pru p 3.

Published
2012

18. Reliability and Intervention Management for the LHC

Author

Foraz, K, De Jonghe, J, Richard Cook, J, Coupard, J, Daudin, B, Baltasar Dos Santos Pedrosa, F, Reguero Fuentes, E, Garino, C, Golikov, K, Grillot, S, Richard Jaekel, M, and Sollander, P

Subjects
Accelerators and Storage Rings
Abstract

Since 2010, CERN has entered a mode of continuous operation of the LHC and its injectors, which implies the continuous operation of all the infrastructure and support systems. High reliability of the machines is crucial to meet the physics goals. This high reliability must be accompanied by a fast restart after programmed stops. Since 2010, an important effort has been put in place, to ease the coordination process during the programmed stops and to reinforce the management of the interventions (preparation, approval, follow-up, traceability, closure). This paper describes the difficulties from the first year related to this coordination, and the impact on operation. The tools developed for the management of the interventions, their assets and the effect on the reliability of the LHC will also be presented and discussed.

Published
2012

20. New N4-substituted piperazine naphthamide derivatives as BACE1 inhibitors

Author

Laras, Y., Garino, C., Dessolin, J., Wecq, C., Rolland, A., Kraus, J.L., Institut de Biologie du Développement de Marseille (IBDM), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2008

21. Identification of candidate genes affecting meat quality in swine

Author

Gorni, C., Garino, C., Iacuaniello, S., Castiglioni, B., Restelli, G.L., Yerle, Manon, Stella, A., Pagnacco, G., Mariani, Patricia, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], MEAT QUALITY, [SDV]Life Sciences [q-bio], PIGS, QUALITE DE VIANDE
Published
2006

23. Naphthyl and Coumarinyl Biarylpiperazine Derivatives as Highly Potent Human beta-Secretase Inhibitors. Design, Synthesis, and Enzymatic BACE-1 and Cell Assays

Author

Garino, C., Tomita, T., nicolas pietrancosta, Laras, Y., Rosas, R., Herbette, G., Bernard Maigret, Quelever, G., Iwatsubo, T., Kraus, J. L., Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Published
2006

24. Enhanced delivery of gamma-secretase inhibitor DAPT into the brain via an ascorbic acid mediated strategy

Author

Quelever, G., Kachidian, P., Melon, C., Garino, C., Laras, Y., nicolas pietrancosta, Sheha, M., Kraus, J. L., Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and CONTENSIN, Magali

Subjects
[CHIM.THER] Chemical Sciences/Medicinal Chemistry, [CHIM.THER]Chemical Sciences/Medicinal Chemistry
Published
2005

25. Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies

Author

nicolas pietrancosta, Maina, F., Dono, R., Moumen, A., Garino, C., Laras, Y., Burlet, S., Quelever, G., Kraus, J. L., Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry
Published
2005

27. Sensitization to Cor a 9 and Cor a 14 is highly specific for a severe hazelnut allergy in Dutch children and adults

Author

Masthoff, L, primary, Mattsson, L, additional, Zuidmeer-Jongejan, L, additional, Lidholm, J, additional, Andersson, K, additional, Akkerdaas, JH, additional, Versteeg, SA, additional, Garino, C, additional, Meijer, Y, additional, Kentie, P, additional, Versluis, A, additional, den Hartog Jager, CF, additional, Bruijnzeel-Koomen, CA, additional, Knulst, AC, additional, van Ree, R, additional, van Hoffen, E, additional, and Pasmans, SG, additional

Published
2013
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28. Component resolved diagnosis in relation to severity of hazelnut allergy across Europe

Author

Datema, MR, primary, Zuidmeer, L, additional, Garino, C, additional, Marsh, J, additional, Lovegrove, A, additional, Clausen, M, additional, Gislason, D, additional, Dubakiene, R, additional, Reig, I, additional, Barreales, L, additional, Knulst, AC, additional, Le, T-M, additional, Kowalski, ML, additional, Jedvzejczak, M, additional, Lidholm, J, additional, Kralimarkova, T, additional, Popov, T, additional, Asero, R, additional, Seneviratne, S, additional, Sinaniotis, N, additional, Papadopoulos, N, additional, Purohit, A, additional, de Blay, F, additional, Bures, P, additional, Vieths, S, additional, Fernández-Rivas, M, additional, Hoffmann-Sommergruber, K, additional, van Ree, R, additional, and Ballmer-Weber, B, additional

Published
2013
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30. Un modelo constitutivo para el análisis de sólidos elastoplásticos sometidos a grandes deformaciones. Parte 1: Formulación teórica y aplicación a metales

Author

Garino, C. and Oliver, X.

Abstract

En el trabajo se presenta la formulación de un modelo constitutivo capaz de simular, de manera general, procesos elastoplásticos con grandes deformaciones. El desarrollo del modelo se basa en la descomposición multiplicativa del tensor gradiente de la deformación F = Fe. Fp. Luego, la energía libre y las variables internas se escriben en la configuración intermedia, en la que se desarrolla el modelo. Mediante el empleo de la fórmula de Doyle y Ericksen se obtiene la expresión espacial del modelo. Finalmente se aplica el modelo general al caso de metales. En este caso se utiliza a posteriori la hipótesis de pequeñas deformaciones elásticas, típica de estos materiales. En otro trabajo que continúa y acompaña al presente se trata la implementación numérica y se presentan ejemplos de aplicación.

Published
1995

40. PFS: A productivity forecasting system for desktop computers to improve grid applications performance in enterprise desktop grid

Author

Salinas, S. A., García Garino, C., Alejandro Zunino, and National Agency for Scientific and Technological Promotion (ANPCyT) (project No. PAE-PICT 2312), Argentine Ministry of Science and Technology (MINCyT), SeCTyP-UNCuyo (projects No. 06B/194 and No. 06B/253).

Subjects
68M20, 68M14, 68T01, Parallel and Distributed Computing, Desktop Grids, Computer Science::Operating Systems, Computer Science::Distributed, Parallel, and Cluster Computing, Enterprise Desktop Grid, computer productivity forecasting, prediction methods, grid scheduling systems, heuristic method
Abstract

An Enterprise Desktop Grid (EDG) is a low cost platform that gathers desktop computers spread over different institutions. This platform uses desktop computers idle time to run Grid applications. We argue that computers in these environments have a predictable productivity that affects a Grid application execution time. In this paper, we propose a system called PFS for computer productivity forecasting that improves Grid applications performance. We simulated 157.500 applications and compared the performance achieved by our proposal against two recent strategies. Our experiments show that a Grid scheduler based on PFS runs applications faster than schedulers based on other selection strategies.

41. Substituted thiazolamide coupled to a redox delivery system: a new gamma-secretase inhibitor with enhanced pharmacokinetic profile

Author

Younes, Y., Quelever, G., Garino, C., nicolas pietrancosta, Shela, M., Bihel, F., Wolfe, M. S., Kraus, J. L., Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique, Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Erhart, Marianne, and CONTENSIN, Magali

Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM.THER] Chemical Sciences/Medicinal Chemistry, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, [CHIM.ORGA] Chemical Sciences/Organic chemistry

42. Halogen-Bonding Interactions and Electrochemical Properties of Unsymmetrical Pyrazole Pincer NiII Halides: A Peculiar Behavior of the Fluoride Complex (PCN)NiF

Author

Luconi L., Garino C., Cerreia Vioglio P., Gobetto R., Chierotti M., Yakhvarov D., Gafurov Z., Morozov V., Sakhapov I., Rossin A., Giambastiani G., Luconi L., Garino C., Cerreia Vioglio P., Gobetto R., Chierotti M., Yakhvarov D., Gafurov Z., Morozov V., Sakhapov I., Rossin A., and Giambastiani G.

Abstract

© 2019 American Chemical Society. Four metal halides of the (tBuPCN)NiX family [X = F (1), Cl (2), Br (3), or I (4); PCN = 1-[3-[(di-tert-butylphosphino)methyl]phenyl]-1H-pyrazole] have been prepared through a direct reaction of the corresponding anhydrous NiX2 salts and the unsymmetrical PCN pincer ligand. Structural information from single-crystal X-ray data, 19F solution nuclear magnetic resonance, and combined electrochemical results [cyclic voltammetry (CV) and in situ electron paramagnetic resonance spectro-electrochemistry] reveal that the fluoride complex 1 is different from the other halides 2-4 in terms of electro-oxidation behavior (presence of three anodic peaks instead of one in the CV profile). 1 is also different from its symmetrical analogue (tBuPCP)NiF in terms of halogen-bonding capability toward the halogen-bond donor, iodopentafluorobenzene (C6F5I, IPFB). The positive Î"S° value for the formation of the 1···IPFB adduct inferred from the van't Hoff plots is in agreement with the existence of (1·H2O) aggregates in solution, not present in 2-4. The high nucleophilicity of the fluoride ligand and the simultaneous presence of electrophilic (acidic) protons on the sidearm of the pyrazole ligand are at the origin of the observed phenomena.

45. A Contribution to the Harmonization of Non-targeted NMR Methods for Data-Driven Food Authenticity Assessment

Author

Piero Mastrorilli, Michael Assfalg, Vito Gallo, Rosa Ragone, Palmira Villa-Valverde, Iola F. Duarte, Maurizio Triggiani, Anna Borioni, Biagia Musio, Antonello Pascazio, Francesco Longobardi, Silvia Davalli, Elisabetta Schievano, Silvia Mari, Stefania Pontrelli, Cristiano Garino, Cristina Airoldi, Carlos Cobas, Flaminia Cesare Marincola, Adele Mucci, Andersson Barison, Antonino Rizzuti, Erwann Hamon, Michelle Markus, Panteleimon G. Takis, Francesco Savorani, Luca Casadei, Freddy Thomas, Fabio Sciubba, Domenico Acquotti, Anatoly P. Sobolev, Claudia Di Napoli, Kim Colson, Elena Sáez-Barajas, Francesca Benevelli, Nicola Intini, Gabriele Costantino, Leociley R. A. Menezes, Marco Arlorio, Domenico Mallamace, Mauro Andrea Cremonini, Pasquale Scapicchio, Raffaele Lamanna, Sophie Guyader, Stefano Todisco, Maria Cecilia Rossi, Mario Latronico, Laura Ruth Cagliani, Maren Hegmanns, Fabio Arnesano, Dolores Molero-Vílchez, Stefano Mammi, Roberto Consonni, Salvatore Milone, Gallo, V, Ragone, R, Musio, B, Todisco, S, Rizzuti, A, Mastrorilli, P, Pontrelli, S, Intini, N, Scapicchio, P, Triggiani, M, Pascazio, A, Cobas, C, Mari, S, Garino, C, Arlorio, M, Acquotti, D, Airoldi, C, Arnesano, F, Assfalg, M, Barison, A, Benevelli, F, Borioni, A, Cagliani, L, Casadei, L, Marincola, F, Colson, K, Consonni, R, Costantino, G, Cremonini, M, Davalli, S, Duarte, I, Guyader, S, Hamon, E, Hegmanns, M, Lamanna, R, Longobardi, F, Mallamace, D, Mammi, S, Markus, M, Menezes, L, Milone, S, Molero-Vilchez, D, Mucci, A, Napoli, C, Rossi, M, Saez-Barajas, E, Savorani, F, Schievano, E, Sciubba, F, Sobolev, A, Takis, P, Thomas, F, Villa-Valverde, P, Latronico, M, Gallo, V., Ragone, R., Musio, B., Todisco, S., Rizzuti, A., Mastrorilli, P., Pontrelli, S., Intini, N., Scapicchio, P., Triggiani, M., Pascazio, A., Cobas, C., Mari, S., Garino, C., Arlorio, M., Acquotti, D., Airoldi, C., Arnesano, F., Assfalg, M., Barison, A., Benevelli, F., Borioni, A., Cagliani, L. R., Casadei, L., Marincola, F. C., Colson, K., Consonni, R., Costantino, G., Cremonini, M. A., Davalli, S., Duarte, I., Guyader, S., Hamon, E., Hegmanns, M., Lamanna, R., Longobardi, F., Mallamace, D., Mammi, S., Markus, M., Menezes, L. R. A., Milone, S., Molero-Vilchez, D., Mucci, A., Napoli, C., Rossi, M. C., Saez-Barajas, E., Savorani, F., Schievano, E., Sciubba, F., Sobolev, A., Takis, P. G., Thomas, F., Villa-Valverde, P., and Latronico, M.

Subjects
Non targeted, Future studies, Inter-laboratory comparison, Computer science, Food authenticity, Food fingerprinting, Non-targeted analysis, NMR, Validation, Human error, computer.software_genre, 01 natural sciences, Applied Microbiology and Biotechnology, Analytical Chemistry, Data-driven, 0404 agricultural biotechnology, non targeted analysis, inter laboratory comparison, Safety, Risk, Reliability and Quality, Equivalence (measure theory), Non-targeted analysis .NMR, 2. Zero hunger, 010401 analytical chemistry, 04 agricultural and veterinary sciences, Nuclear magnetic resonance spectroscopy, Non-targeted analysi, 040401 food science, 0104 chemical sciences, Identification (information), Food products, Data mining, Safety Research, computer, Food Science
Abstract

Spectroscopic non-targeted methods are gaining ever-growing importance in quality control and authenticity assessment of food products because of their strong potential for identification of specific features of the products by data-driven classifiers. One of the factors hampering the diffusion of spectroscopic non-targeted methods and data-driven classifiers is the lack of harmonized guidelines for their development and validation. In particular, to date, neither conditions to directly compare spectra recorded by different spectrometers nor studies demonstrating the statistical equivalence of the spectra are available. Among the spectroscopic analytical techniques suitable for the development of non-targeted methods, nuclear magnetic resonance (NMR) offers the unique opportunity to generate statistically equivalent signals. In this paper, the feasibility of NMR spectroscopy to generate statistically equivalent NMR signals from a number of different spectrometers was demonstrated for complex mixtures (aqueous extracts of wheat and flour) by organizing an inter-laboratory comparison involving 36 NMR spectrometers. Univariate statistics along with multivariate analysis were exploited to establish unbiased criteria for assessing the statistical equivalence of the NMR signals. The aspects affecting the signal equivalence were investigated, and possible solutions to reduce the extent of the human error were proposed and applied with satisfactory results. This study furnishes the scientific community with an appropriate and easy procedure to validate non-targeted NMR methods and provides error values to be used as a reference for future studies.

Published
2019

46. Appendectomy during the COVID-19 pandemic in Italy: a multicenter ambispective cohort study by the Italian Society of Endoscopic Surgery and new technologies (the CRAC study)

Author

Sartori A., Podda M., Botteri E., Passera R., Agresta F., Arezzo A., Guerrieri M., Ortenzi M., Cavallo F., Zese M., Prando D., Restini E., Cianci P., Millo P., Brachet Contul R., Serrao A., Abatini F., Altomare D. F., Picciariello A., Chetta G., Lattanzio F., Tonini V., Gori A., Jovine E., Mastrangelo L., Sartarelli L., Frena A., Malpaga A., Bertelli F., Pignata G., Andreuccetti J., Sanna S., Lares B., Sechi R., Cillara N., Pisanu A., Delogu D., Ciaccio G., Farulla M., Casati M., Laface L., De Luca M., Russello D., Latteri S., Longoni M., Masci E., Vigna S., Campanile F. C., Foti N., Lepiane P., Balla A., Cantore F., Raveglia V., Borghi F., Giraudo G., Verzelli A., Budassi A., Patriti A., Foghetti D., Montin U., Amadio L., Anania G., Bombardini C., Fabbri N., Feo C., Cianchi F., Manetti A., Lucchese M., Soricelli E., Ceccarelli G., Patiti M., Frascio M., Stabilini C., Filauro M., Barberis A., Troian M., Nagliati C., Campagnacci R., Maurizi A., Berti S., Gennai A., Marvaso A., D'Antonio D., Feo C. V., Mazzola L., Selvaggi F., Carini S., Costanzo F., Boccia L., Pascariello A., Perrotta N., Celiento M., Opocher E., Giovenzana M., Stella M., Ferrara F., Boni L., Abate E., Da Lio C., Valli V., Gelmini R., Serra F., Piccoli M., Gozzo D., Gattolin A., Sasia D., Balani A., Petronio B., Calo P. G., Canu G. L., Contarini E., Piatto G., Vettoretto N., Caprioli M., Braga M., Chiappetta M. F., Maida P., Tammaro P., De Palma G., Milone M., Bottino V., Canfora A., Bagaglini G., Agrusa A., Barone M., Mirabella A., Marino M. V., Gulotta G., Romano G., Sorrentino M., Ferfoglia S., Papagni V., Eramo S., Boselli C., Basti M., Caracino V., Moretto G., Inama M., Capelli P., Conti L., Muratore A., Cuoghi M. M., Zerbinati A., Corso S., Vasino M. C., Montuori M., Fidanza F., Lucchetta A., Giuliani A., Dinatale G., Zanzi F., Guariniello A., Bonilauri S., Frazzetta G., Garino M., Marafante C., Gioffre A., Del Monte S. R., Sganga G., Fransvea P., Grande M., Siragusa L., Sica G., Paola M., Passantino D. G., Catani M., Ricci F., Lauro E., Facci E., Parini D., Armellino M. F., Argenio G., Porcu A., Perra T., Bordoni P., Fleres F., Parisi A., Rossi S., Saracco R., Bono D., Viora T., Orlando F., Ferrero A., Fontana A. P., De Paolis P., Visconti D., Quaglino F., Festa F., Palagi S., Lo Secco G., Morino M., Allaix M. E., Salzano A., Tirone G., Motter M., Zanus G., Passuello N., Massani M., Tutino R., Manzini N., Terranova S., Merenda R., Nordio S., Zonta S., Lovisetto F., Guglielmi A., Campagnaro T., Amedeo E., Scollica M., Amodio P., Giannotti D., Olmi S., Oldani A., Sartori, A., Podda, M., Botteri, E., Passera, R., Agresta, F., Arezzo, A., Guerrieri, M., Ortenzi, M., Cavallo, F., Zese, M., Prando, D., Restini, E., Cianci, P., Millo, P., Brachet Contul, R., Serrao, A., Abatini, F., Altomare, D. F., Picciariello, A., Chetta, G., Lattanzio, F., Tonini, V., Gori, A., Jovine, E., Mastrangelo, L., Sartarelli, L., Frena, A., Malpaga, A., Bertelli, F., Pignata, G., Andreuccetti, J., Sanna, S., Lares, B., Sechi, R., Cillara, N., Pisanu, A., Delogu, D., Ciaccio, G., Farulla, M., Casati, M., Laface, L., De Luca, M., Russello, D., Latteri, S., Longoni, M., Masci, E., Vigna, S., Campanile, F. C., Foti, N., Lepiane, P., Balla, A., Cantore, F., Raveglia, V., Borghi, F., Giraudo, G., Verzelli, A., Budassi, A., Patriti, A., Foghetti, D., Montin, U., Amadio, L., Anania, G., Bombardini, C., Fabbri, N., Feo, C., Cianchi, F., Manetti, A., Lucchese, M., Soricelli, E., Ceccarelli, G., Patiti, M., Frascio, M., Stabilini, C., Filauro, M., Barberis, A., Troian, M., Nagliati, C., Campagnacci, R., Maurizi, A., Berti, S., Gennai, A., Marvaso, A., D'Antonio, D., Feo, C. V., Mazzola, L., Selvaggi, F., Carini, S., Costanzo, F., Boccia, L., Pascariello, A., Perrotta, N., Celiento, M., Opocher, E., Giovenzana, M., Stella, M., Ferrara, F., Boni, L., Abate, E., Da Lio, C., Valli, V., Gelmini, R., Serra, F., Piccoli, M., Gozzo, D., Gattolin, A., Sasia, D., Balani, A., Petronio, B., Calo, P. G., Canu, G. L., Contarini, E., Piatto, G., Vettoretto, N., Caprioli, M., Braga, M., Chiappetta, M. F., Maida, P., Tammaro, P., De Palma, G., Milone, M., Bottino, V., Canfora, A., Bagaglini, G., Agrusa, A., Barone, M., Mirabella, A., Marino, M. V., Gulotta, G., Romano, G., Sorrentino, M., Ferfoglia, S., Papagni, V., Eramo, S., Boselli, C., Basti, M., Caracino, V., Moretto, G., Inama, M., Capelli, P., Conti, L., Muratore, A., Cuoghi, M. M., Zerbinati, A., Corso, S., Vasino, M. C., Montuori, M., Fidanza, F., Lucchetta, A., Giuliani, A., Dinatale, G., Zanzi, F., Guariniello, A., Bonilauri, S., Frazzetta, G., Garino, M., Marafante, C., Gioffre, A., Del Monte, S. R., Sganga, G., Fransvea, P., Grande, M., Siragusa, L., Sica, G., Paola, M., Passantino, D. G., Catani, M., Ricci, F., Lauro, E., Facci, E., Parini, D., Armellino, M. F., Argenio, G., Porcu, A., Perra, T., Bordoni, P., Fleres, F., Parisi, A., Rossi, S., Saracco, R., Bono, D., Viora, T., Orlando, F., Ferrero, A., Fontana, A. P., De Paolis, P., Visconti, D., Quaglino, F., Festa, F., Palagi, S., Lo Secco, G., Morino, M., Allaix, M. E., Salzano, A., Tirone, G., Motter, M., Zanus, G., Passuello, N., Massani, M., Tutino, R., Manzini, N., Terranova, S., Merenda, R., Nordio, S., Zonta, S., Lovisetto, F., Guglielmi, A., Campagnaro, T., Amedeo, E., Scollica, M., Amodio, P., Giannotti, D., Olmi, S., Oldani, A., Sartori A., Podda M., Botteri E., Passera R., Agresta F., Arezzo A., Guerrieri M., Ortenzi M., Cavallo F., Zese M., Prando D., Restini E., Cianci P., Millo P., Brachet Contul R., Serrao A., Abatini F., Altomare D.F., Picciariello A., Chetta G., Lattanzio F., Tonini V., Gori A., Jovine E., Mastrangelo L., Sartarelli L., Frena A., Malpaga A., Bertelli F., Pignata G., Andreuccetti J., Sanna S., Lares B., Sechi R., Cillara N., Pisanu A., Delogu D., Ciaccio G., Farulla M., Casati M., Laface L., De Luca M., Russello D., Latteri S., Longoni M., Masci E., Vigna S., Campanile F.C., Foti N., Lepiane P., Balla A., Cantore F., Raveglia V., Borghi F., Giraudo G., Verzelli A., Budassi A., Patriti A., Foghetti D., Montin U., Amadio L., Anania G., Bombardini C., Fabbri N., Feo C., Cianchi F., Manetti A., Lucchese M., Soricelli E., Ceccarelli G., Patiti M., Frascio M., Stabilini C., Filauro M., Barberis A., Troian M., Nagliati C., Campagnacci R., Maurizi A., Berti S., Gennai A., Marvaso A., D'Antonio D., Feo C.V., Mazzola L., Selvaggi F., Carini S., Costanzo F., Boccia L., Pascariello A., Perrotta N., Celiento M., Opocher E., Giovenzana M., Stella M., Ferrara F., Boni L., Abate E., Da Lio C., Valli V., Gelmini R., Serra F., Piccoli M., Gozzo D., Gattolin A., Sasia D., Balani A., Petronio B., Calo P.G., Canu G.L., Contarini E., Piatto G., Vettoretto N., Caprioli M., Braga M., Chiappetta M.F., Maida P., Tammaro P., De Palma G., Milone M., Bottino V., Canfora A., Bagaglini G., Agrusa A., Barone M., Mirabella A., Marino M.V., Gulotta G., Romano G., Sorrentino M., Ferfoglia S., Papagni V., Eramo S., Boselli C., Basti M., Caracino V., Moretto G., Inama M., Capelli P., Conti L., Muratore A., Cuoghi M.M., Zerbinati A., Corso S., Vasino M.C., Montuori M., Fidanza F., Lucchetta A., Giuliani A., Dinatale G., Zanzi F., Guariniello A., Bonilauri S., Frazzetta G., Garino M., Marafante C., Gioffre A., Del Monte S.R., Sganga G., Fransvea P., Grande M., Siragusa L., Sica G., Paola M., Passantino D.G., Catani M., Ricci F., Lauro E., Facci E., Parini D., Armellino M.F., Argenio G., Porcu A., Perra T., Bordoni P., Fleres F., Parisi A., Rossi S., Saracco R., Bono D., Viora T., Orlando F., Ferrero A., Fontana A.P., De Paolis P., Visconti D., Quaglino F., Festa F., Palagi S., Lo Secco G., Morino M., Allaix M.E., Salzano A., Tirone G., Motter M., Zanus G., Passuello N., Massani M., Tutino R., Manzini N., Terranova S., Merenda R., Nordio S., Zonta S., Lovisetto F., Guglielmi A., Campagnaro T., Amedeo E., Scollica M., Amodio P., Giannotti D., Olmi S., Oldani A., Sartori, Alberto, Podda, Mauro, Botteri, Emanuele, Passera, Roberto, Agresta, Ferdinando, Arezzo, Alberto, M Guerrieri, M Ortenzi, F Cavallo, M Zese, D Prando, E Restini, P Cianci, P Millo, R Brachet Contul, A Serrao, F Abatini, D F Altomare, A Picciariello, G Chetta, F Lattanzio, V Tonini, A Gori, E Jovine, L Mastrangelo, L Sartarelli, A Frena, A Malpaga, F Bertelli, G Pignata, J Andreuccetti, S Sanna, B Lares, R Sechi, N Cillara, A Pisanu, D Delogu, G Ciaccio, M Farulla, M Casati, L Laface, M De Luca, D Russello, S Latteri, M Longoni, E Masci, S Vigna, F C Campanile, N Foti, P Lepiane, A Balla, F Cantore, V Raveglia, F Borghi, G Giraudo, A Verzelli, A Budassi, A Patriti, D Foghetti, U Montin, L Amadio, G Anania, C Bombardini, Niccolò Fabbri, Carlo Feo, F Cianchi, A Manetti, M Lucchese, E Soricelli, G Ceccarelli, M Patiti, M Frascio, C Stabilini, M Filauro, A Barberis, M Troian, C Nagliati, R Campagnacci, A Maurizi, S Berti, A Gennai, A Marvaso, D D'Antonio, C V Feo, N Fabbri, L Mazzola, F Selvaggi, S Carini, F Costanzo, L Boccia, A Pascariello, N Perrotta, M Celiento, E Opocher, M Giovenzana, M Stella, F Ferrara, L Boni, E Abate, C Da Lio, V Valli, R Gelmini, F Serra, M Piccoli, D Gozzo, A Gattolin, D Sasia, A Balani, B Petronio, P G Calò, G L Canu, E Contarini, G Piatto, N Vettoretto, M Caprioli, M Braga, M F Chiappetta, P Maida, P Tammaro, G De Palma, M Milone, V Bottino, A Canfora, F Selvaggi, G Bagaglini, A Agrusa, M Barone, A Mirabella, M V Marino, G Gulotta, G Romano, M Sorrentino, S Ferfoglia, V Papagni, S Eramo, C Boselli, M Basti, V Caracino, G Moretto, M Inama, P Capelli, L Conti, A Muratore, M M Cuoghi, A Zerbinati, S Corso, M C Vasino, M Montuori, F Fidanza, A Lucchetta, A Giuliani, G Dinatale, F Zanzi, A Guariniello, S Bonilauri, G Frazzetta, M Garino, C Marafante, A Gioffrè, S R Del Monte, G Sganga, P Fransvea, M Grande, L Siragusa, G Sica, M Paola, D G Passantino, Marco Catani, F Ricci, E Lauro, E Facci, D Parini, M F Armellino, G Argenio, A Porcu, T Perra, P Bordoni, F Fleres, A Parisi, S Rossi, R Saracco, D Bono, T Viora, F Orlando, A Ferrero, A P Fontana, P De Paolis, D Visconti, F Quaglino, F Festa, S Palagi, G Lo Secco, M Morino, M E Allaix, A Salzano, G Tirone, M Motter, G Zanus, N Passuello, M Massani, R Tutino, N Manzini, S Terranova, R Merenda, S Nordio, S Zonta, F Lovisetto, A Guglielmi, T Campagnaro, E Amedeo, M Scollica, P Amodio, D Giannotti, S Olmi, A Oldani, Sartori, A, Podda, M, Botteri, E, Passera, R, Agresta, F, Arezzo, A, Guerrieri, M, Ortenzi, M, Cavallo, F, Zese, M, Prando, D, Restini, E, Cianci, P, Millo, P, Brachet Contul, R, Serrao, A, Abatini, F, Altomare, D, Picciariello, A, Chetta, G, Lattanzio, F, Tonini, V, Gori, A, Jovine, E, Mastrangelo, L, Sartarelli, L, Frena, A, Malpaga, A, Bertelli, F, Pignata, G, Andreuccetti, J, Sanna, S, Lares, B, Sechi, R, Cillara, N, Pisanu, A, Delogu, D, Ciaccio, G, Farulla, M, Casati, M, Laface, L, De Luca, M, Russello, D, Latteri, S, Longoni, M, Masci, E, Vigna, S, Campanile, F, Foti, N, Lepiane, P, Balla, A, Cantore, F, Raveglia, V, Borghi, F, Giraudo, G, Verzelli, A, Budassi, A, Patriti, A, Foghetti, D, Montin, U, Amadio, L, Anania, G, Bombardini, C, Fabbri, N, Feo, C, Cianchi, F, Manetti, A, Lucchese, M, Soricelli, E, Ceccarelli, G, Patiti, M, Frascio, M, Stabilini, C, Filauro, M, Barberis, A, Troian, M, Nagliati, C, Campagnacci, R, Maurizi, A, Berti, S, Gennai, A, Marvaso, A, D'Antonio, D, Mazzola, L, Selvaggi, F, Carini, S, Costanzo, F, Boccia, L, Pascariello, A, Perrotta, N, Celiento, M, Opocher, E, Giovenzana, M, Stella, M, Ferrara, F, Boni, L, Abate, E, Da Lio, C, Valli, V, Gelmini, R, Serra, F, Piccoli, M, Gozzo, D, Gattolin, A, Sasia, D, Balani, A, Petronio, B, Calo, P, Canu, G, Contarini, E, Piatto, G, Vettoretto, N, Caprioli, M, Braga, M, Chiappetta, M, Maida, P, Tammaro, P, De Palma, G, Milone, M, Bottino, V, Canfora, A, Bagaglini, G, Agrusa, A, Barone, M, Mirabella, A, Marino, M, Gulotta, G, Romano, G, Sorrentino, M, Ferfoglia, S, Papagni, V, Eramo, S, Boselli, C, Basti, M, Caracino, V, Moretto, G, Inama, M, Capelli, P, Conti, L, Muratore, A, Cuoghi, M, Zerbinati, A, Corso, S, Vasino, M, Montuori, M, Fidanza, F, Lucchetta, A, Giuliani, A, Dinatale, G, Zanzi, F, Guariniello, A, Bonilauri, S, Frazzetta, G, Garino, M, Marafante, C, Gioffre, A, Del Monte, S, Sganga, G, Fransvea, P, Grande, M, Siragusa, L, Sica, G, Paola, M, Passantino, D, Catani, M, Ricci, F, Lauro, E, Facci, E, Parini, D, Armellino, M, Argenio, G, Porcu, A, Perra, T, Bordoni, P, Fleres, F, Parisi, A, Rossi, S, Saracco, R, Bono, D, Viora, T, Orlando, F, Ferrero, A, Fontana, A, De Paolis, P, Visconti, D, Quaglino, F, Festa, F, Palagi, S, Lo Secco, G, Morino, M, Allaix, M, Salzano, A, Tirone, G, Motter, M, Zanus, G, Passuello, N, Massani, M, Tutino, R, Manzini, N, Terranova, S, Merenda, R, Nordio, S, Zonta, S, Lovisetto, F, Guglielmi, A, Campagnaro, T, Amedeo, E, Scollica, M, Amodio, P, Giannotti, D, Olmi, S, and Oldani, A

Subjects
medicine.medical_specialty, COVID-19 Pandemic, Coronavirus disease 2019 (COVID-19), Endoscopic surgery, NO, Appendectomy, Appendicitis, Machine learning, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Retrospective Studie, Pandemic, medicine, Humans, Appendiciti, Laparoscopy, Pandemics, Retrospective Studies, medicine.diagnostic_test, business.industry, COVID-19 Pandemic, Appendicitis, Appendicectomy, Machine learning, SARS-CoV-2, COVID-19, Length of Stay, medicine.disease, Settore MED/18, Surgery, Italy, 030220 oncology & carcinogenesis, appendicitis, COVID-19 pandemic, machine learning, appendectomy, cohort studies, humans, length of stay, pandemics, postoperative complications, retrospective studies, laparoscopy, 030211 gastroenterology & hepatology, Observational study, Original Article, Postoperative Complication, Appendicectomy, Cohort Studie, business, Complication, Cohort study, Human
Abstract

Major surgical societies advised using non-operative management of appendicitis and suggested against laparoscopy during the COVID-19 pandemic. The hypothesis is that a significant reduction in the number of emergent appendectomies was observed during the pandemic, restricted to complex cases. The study aimed to analyse emergent surgical appendectomies during pandemic on a national basis and compare it to the same period of the previous year. This is a multicentre, retrospective, observational study investigating the outcomes of patients undergoing emergent appendectomy in March–April 2019 vs March–April 2020. The primary outcome was the number of appendectomies performed, classified according to the American Association for the Surgery of Trauma (AAST) score. Secondary outcomes were the type of surgical technique employed (laparoscopic vs open) and the complication rates. One thousand five hundred forty one patients with acute appendicitis underwent surgery during the two study periods. 1337 (86.8%) patients met the inclusion criteria: 546 (40.8%) patients underwent surgery for acute appendicitis in 2020 and 791 (59.2%) in 2019. According to AAST, patients with complicated appendicitis operated in 2019 were 30.3% vs 39.9% in 2020 (p = 0.001). We observed an increase in the number of post-operative complications in 2020 (15.9%) compared to 2019 (9.6%) (p 24 h after admission (+ 58%), open surgery (+ 112%) and conversion to open surgery (+ 166%). In Italian hospitals, in March and April 2020, the number of appendectomies has drastically dropped. During the first pandemic wave, patients undergoing surgery were more frequently affected by more severe appendicitis than the previous year's timeframe and experienced a higher number of complications. Trial registration number and date: Research Registry ID 5789, May 7th, 2020

Published
2021

47. Teaching Inorganic Photophysics and Photochemistry with Three Ruthenium(II) Polypyridyl Complexes: A Computer-Based Exercise

Author

Luca Salassa, Giampaolo Barone, Alessio Terenzi, Claudio Garino, Garino, C., Terenzi, A., Barone, G., and Salassa, L.

Subjects
Laboratory Instruction, Hands-On Learning/Manipulative, Photochemistry, chemistry.chemical_element, Graduate Education/Research, Coordination Compounds, 010402 general chemistry, 01 natural sciences, Physical Chemistry, Education, Coordination complex, Inorganic Chemistry, Transition metal, Calculator-Based Learning, Continuing Education, Hands-On Learning/Manipulatives, Upper-Division Undergraduate, Chemistry (all), 3304, Molecule, chemistry.chemical_classification, Science instruction, 05 social sciences, Computer based, 050301 education, Continuing education, General Chemistry, 0104 chemical sciences, 3. Good health, Ruthenium, chemistry, Coordination Compound, Settore CHIM/03 - Chimica Generale E Inorganica, Density functional theory, 0503 education
Abstract

Among computational methods, DFT (density functional theory) and TD-DFT (time-dependent DFT) are widely used in research to describe, inter alia, the optical properties of transition metal complexes. Inorganic/physical chemistry courses for undergraduate students treat such methods, but quite often only from the theoretical point of view. In the calculation exercise herein described, students are guided step by step through the computational study of the photophysics and photochemistry of polypyridyl Ru(II) d6-metal complexes. In particular, by means of DFT and TD-DFT calculations, they are asked to examine and interpret a set of experimental data describing the absorption, emission, and photochemical behavior of three structurally related ruthenium complexes, namely, [Ru(bpy)3]2+ (1), [Ru(tpy)2]2+ (2), and [Ru(bpy)2(py)2]2+ (3). These complexes are particularly suitable for an educational purpose since they exhibit distinct optical and photochemical properties despite being structurally akin to each other. In the computational chemistry laboratory, the instructor progressively guides students through the preparation of DFT and TD-DFT inputs and the use of software for the analysis of output files, including visualization of optimized geometries, absorption spectra, orbitals, and spin density surfaces. The exercise covers training of students in several key concepts concerning the photophysics and photochemistry of transition metal complexes. These include Franck-Condon transitions and the role of 3MLCT (metal-to-ligand charge transfer) and 3MC (metal-centered or ligand-field) states in luminescence and ligand photodissociation processes. Notably, the mixed character of this exercise allows its integration with theoretical and experimental activities and the design of truly multidisciplinary courses.

Published
2016

49. One-Dimensional and Two-Dimensional Zn(II) Coordination Polymers with Ditopic Imidazo[1,5- a ]pyridine: A Structural and Computational Study.

Author

Sozzi M, Chierotti MR, Gobetto R, Gomila RM, Marzaroli V, Priola E, Volpi G, Zago S, Frontera A, and Garino C

Abstract

Zn(II) coordination polymers are being increasingly studied for their stability and properties. Similarly, there is a growing interest in imidazo[1,5- a ]pyridine derivatives, which show great potential in luminescence and pharmaceutical applications. In this work, we successfully synthesized and crystallized three new coordination polymers, using Zn(II) as the metallic node, dicarboxylic acids of different length and nature as linkers, and a linear ditopic imidazo[1,5- a ]pyridine derivative, to explore the role of this molecule as a propagator of the dimensionality of the structure or as an ancillary ligand. Our work demonstrates the structural capability of imidazo[1,5- a ]pyridines in an unexplored domain for this family of ligands. Notably, we observed a pronounced ability of this heterocyclic scaffold to establish π···π interactions in the solid state. The supramolecular π-stacked assemblies were theoretically analyzed using DFT calculations based on model structures.

Published
2024
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50. Mono-, Bis-, and Tris-Chelate Zn(II) Complexes with Imidazo[1,5- a ]pyridine: Luminescence and Structural Dependence.

Author

Cerrato V, Volpi G, Priola E, Giordana A, Garino C, Rabezzana R, and Diana E

Abstract

New mono-, bis-, and tris-chelate Zn(II) complexes have been synthesized starting from different Zn(II) salts and employing a fluorescent 1,3-substituted-imidazo[1,5- a ]pyridine as a chelating ligand. The products have been characterized by single-crystal X-ray diffraction; mass spectrometry; and vibrational spectroscopy. The optical properties have been investigated to compare the performances of mono-, bis-, and tris-chelate forms. The collected data (in the solid state and in solution) elucidate an important modification of the ligand conformation upon metal coordination; which is responsible for a notable increase in the optical performance. An intense modification of the emission quantum yield along the series in the solid state is observed comparing mono-, bis-, and tris-chelate adducts; independently from the anionic ligand introduced by ionic exchange.

Published
2023
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