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12 results on '"Garijo, Olivia"'

1. Self-Replicating RNAs Drive Protective Anti-tumor T Cell Responses to Neoantigen Vaccine Targets in a Combinatorial Approach

Author

Maine, Christian J., Richard, Guilhem, Spasova, Darina S., Miyake-Stoner, Shigeki J., Sparks, Jessica, Moise, Leonard, Sullivan, Ryan P., Garijo, Olivia, Choz, Melissa, Crouse, Jenna M., Aguilar, Allison, Olesiuk, Melanie D., Lyons, Katie, Salvador, Katrina, Blomgren, Melissa, DeHart, Jason L., Kamrud, Kurt I., Berdugo, Gad, De Groot, Anne S., Wang, Nathaniel S., and Aliahmad, Parinaz

Published
2021
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2. Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes

Author

Ozog, Stosh, Timberlake, Nina D., Hermann, Kip, Garijo, Olivia, Haworth, Kevin G., Shi, Guoli, Glinkerman, Christopher M., Schefter, Lauren E., D'Souza, Saritha, Simpson, Elizabeth, Sghia-Hughes, Gabriella, Carillo, Raymond R., Boger, Dale L., Kiem, Hans-Peter, Slukvin, Igor, Ryu, Byoung Y., Sorrentino, Brian P., Adair, Jennifer E., Snyder, Scott A., Compton, Alex A., and Torbett, Bruce E.

Published
2019
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7. Dendritic epidermal T cells regulate skin antimicrobial barrier function

Author

MacLeod, Amanda S., Hemmers, Saskia, Garijo, Olivia, Chabod, Marianne, Mowen, Kerri, Witherden, Deborah A., and Havran, Wendy L.

Subjects
Testing, Research, Properties, Interleukins -- Properties, Immune response -- Research, T cells -- Testing
Abstract

The epidermis, the outer layer of the skin, forms a physical and antimicrobial shield to protect the body from environmental threats. Skin injury severely compromises the epidermal barrier and requires [...]

Published
2013
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8. The junctional adhesion molecule JAML is a costimulatory receptor for epithelial [gamma][delta] T cell activation

Author

Witherden, Deborah A., Verdino, Petra, Rieder, Stephanie E., Garijo, Olivia, Mitts, Robyn E., Teyton, Luc, Fischer, Wolfgang H., Wilson, Ian A., and Havran, Wendy L.

Subjects
Protein binding -- Research, Proteins -- Chemical properties, T cells -- Genetic aspects, T cells -- Chemical properties, Science and technology
Abstract

[gamma][delta] T cells present in epithelia[ tissues provide a crucial first line of defense against environmental insults, including infection, trauma, and malignancy, yet the molecular events surrounding their activation remain poorly defined. Here we identify an epithelial [gamma][delta] T cell--specific costimulatory molecule, junctional adhesion molecule--like protein (JAML). Binding of JAML to its ligand Coxsackie and adenovirus receptor (CAR) provides costimulation leading to cellular proliferation and cytokine and growth factor production. Inhibition of JAML costimulation leads to diminished [gamma][delta] T cell activation and delayed wound closure akin to that seen in the absence of [gamma][delta] T cells. Our results identify JAML as a crucial component of epithelial [gamma][delta] T cell biology and have broader implications for CAR and JAML in tissue homeostasis and repair. 10.1126/science.1192698

Published
2010
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11. Prostaglandin E2Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells

Author

Heffner, Garrett C., Bonner, Melissa, Christiansen, Lauryn, Pierciey, Francis J., Campbell, Dakota, Smurnyy, Yegor, Zhang, Wenliang, Hamel, Amanda, Shaw, Seema, Lewis, Gretchen, Goss, Kendrick A., Garijo, Olivia, Torbett, Bruce E., Horton, Holly, Finer, Mitchell H., Gregory, Philip D., and Veres, Gabor

Abstract

Gene therapy currently in development for hemoglobinopathies utilizes ex vivo lentiviral transduction of CD34+hematopoietic stem and progenitor cells (HSPCs). A small-molecule screen identified prostaglandin E2(PGE2) as a positive mediator of lentiviral transduction of CD34+cells. Supplementation with PGE2increased lentiviral vector (LVV) transduction of CD34+cells approximately 2-fold compared to control transduction methods with no effect on cell viability. Transduction efficiency was consistently increased in primary CD34+cells from multiple normal human donors and from patients with β-thalassemia or sickle cell disease. Notably, PGE2increased transduction of repopulating human HSPCs in an immune-deficient (nonobese diabetic/severe combined immunodeficiency/interleukin-2 gamma receptor null [NSG]) xenotransplantation mouse model without evidence of in vivo toxicity, lineage bias, or a de novo bias of lentiviral integration sites. These data suggest that PGE2improves lentiviral transduction and increases vector copy number, therefore resulting in increased transgene expression. As a result, PGE2may be useful in clinical gene therapy applications using lentivirally modified HSPCs.

Published
2018
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