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1. Interim report for the International Muon Collider Collaboration (IMCC)

Author

Accettura, C., Adrian, S., Agarwal, R., Ahdida, C., Aimé, C., Aksoy, A., Alberghi, G. L., Alden, S., Amapane, N., Amorim, D., Andreetto, P., Anulli, F., Appleby, R., Apresyan, A., Asadi, P., Mahmoud, M. Attia, Auchmann, B., Back, J., Badea, A., Bae, K. J., Bahng, E. J., Balconi, L., Balli, F., Bandiera, L., Barbagallo, C., Barlow, R., Bartoli, C., Bartosik, N., Barzi, E., Batsch, F., Bauce, M., Begel, M., Berg, J. S., Bersani, A., Bertarelli, A., Bertinelli, F., Bertolin, A., Bhat, P., Bianchi, C., Bianco, M., Bishop, W., Black, K., Boattini, F., Bogacz, A., Bonesini, M., Bordini, B., de Sousa, P. Borges, Bottaro, S., Bottura, L., Boyd, S., Breschi, M., Broggi, F., Brunoldi, M., Buffat, X., Buonincontri, L., Burrows, P. N., Burt, G. C., Buttazzo, D., Caiffi, B., Calatroni, S., Calviani, M., Calzaferri, S., Calzolari, D., Cantone, C., Capdevilla, R., Carli, C., Carrelli, C., Casaburo, F., Casarsa, M., Castelli, L., Catanesi, M. G., Cavallucci, L., Cavoto, G., Celiberto, F. G., Celona, L., Cemmi, A., Ceravolo, S., Cerri, A., Cerutti, F., Cesarini, G., Cesarotti, C., Chancé, A., Charitonidis, N., Chiesa, M., Chiggiato, P., Ciccarella, V. L., Puviani, P. Cioli, Colaleo, A., Colao, F., Collamati, F., Costa, M., Craig, N., Curtin, D., D'Angelo, L., Da Molin, G., Damerau, H., Dasu, S., de Blas, J., De Curtis, S., De Gersem, H., Del Moro, T., Delahaye, J. -P., Denisov, D., Denizli, H., Dermisek, R., Valdor, P. Desiré, Desponds, C., Di Luzio, L., Di Meco, E., Di Petrillo, K. F., Di Sarcina, I., Diociaiuti, E., Dorigo, T., Dreimanis, K., Pree, T. du, Edgecock, T., Fabbri, S., Fabbrichesi, M., Farinon, S., Ferrand, G., Somoza, J. A. Ferreira, Fieg, M., Filthaut, F., Fox, P., Franceschini, R., Ximenes, R. Franqueira, Gallinaro, M., Garcia-Sciveres, M., Garcia-Tabares, L., Gargiulo, R., Garion, C., Garzelli, M. V., Gast, M., Gerber, C. E., Giambastiani, L., Gianelle, A., Gianfelice-Wendt, E., Gibson, S., Gilardoni, S., Giove, D. A., Giovinco, V., Giraldin, C., Glioti, A., Gorzawski, A., Greco, M., Grojean, C., Grudiev, A., Gschwendtner, E., Gueli, E., Guilhaudin, N., Han, C., Han, T., Hauptman, J. M., Herndon, M., Hillier, A. D., Hillman, M., Holmes, T. R., Homiller, S., Jana, S., Jindariani, S., Johannesson, S., Johnson, B., Jones, O. R., Jurj, P. -B., Kahn, Y., Kamath, R., Kario, A., Karpov, I., Kelliher, D., Kilian, W., Kitano, R., Kling, F., Kolehmainen, A., Kong, K. C., Kosse, J., Krintiras, G., Krizka, K., Kumar, N., Kvikne, E., Kyle, R., Laface, E., Lane, K., Latina, A., Lechner, A., Lee, J., Lee, L., Lee, S. W., Lefevre, T., Leonardi, E., Lerner, G., Li, P., Li, Q., Li, T., Li, W., Voti, R. Li, Lindroos, M., Lipton, R., Liu, D., Liu, M., Liu, Z., Lombardi, A., Lomte, S., Long, K., Longo, L., Lorenzo, J., Losito, R., Low, I., Lu, X., Lucchesi, D., Luo, T., Lupato, A., Métral, E., Mękała, K., Ma, Y., Mańczak, J. M., Machida, S., Madlener, T., Magaletti, L., Maggi, M., Durand, H. Mainaud, Maltoni, F., Mandurrino, M., Marchand, C., Mariani, F., Marin, S., Mariotto, S., Martin-Haugh, S., Masullo, M. R., Mauro, G. S., Mazzolari, A., Mele, B., Meloni, F., Meng, X., Mentink, M., Miceli, R., Milas, N., Mohammadi, A., Moll, D., Montella, A., Morandin, M., Morrone, M., Mulder, T., Musenich, R., Nardecchia, M., Nardi, F., Neuffer, D., Newbold, D., Novelli, D., Olvegård, M., Onel, Y., Orestano, D., Osborne, J., Otten, S., Torres, Y. M. Oviedo, Paesani, D., Griso, S. Pagan, Pagani, D., Pal, K., Palmer, M., Pampaloni, A., Panci, P., Pani, P., Papaphilippou, Y., Paparella, R., Paradisi, P., Passeri, A., Pastrone, N., Pellecchia, A., Piccinini, F., Piekarz, H., Pieloni, T., Plouin, J., Portone, A., Potamianos, K., Potdevin, J., Prestemon, S., Puig, T., Qiang, J., Quettier, L., Rabemananjara, T. R., Radicioni, E., Radogna, R., Rago, I. C., Ratkus, A., Resseguie, E., Reuter, J., Ribani, P. L., Riccardi, C., Ricciardi, S., Robens, T., Robert, Y., Roger, C., Rojo, J., Romagnoni, M., Ronald, K., Rosser, B., Rossi, C., Rossi, L., Rozanov, L., Ruhdorfer, M., Ruiz, R., Queiroz, F. S., Saini, S., Sala, F., Salierno, C., Salmi, T., Salvini, P., Salvioni, E., Sammut, N., Santini, C., Saputi, A., Sarra, I., Scarantino, G., Schneider-Muntau, H., Schulte, D., Scifo, J., Sen, T., Senatore, C., Senol, A., Sertore, D., Sestini, L., Rêgo, R. C. Silva, Simone, F. M., Skoufaris, K., Sorbello, G., Sorbi, M., Sorti, S., Soubirou, L., Spataro, D., Stamerra, A., Stapnes, S., Stark, G., Statera, M., Stechauner, B. M., Su, S., Su, W., Sun, X., Sytov, A., Tang, J., Taylor, R., Kate, H. Ten, Testoni, P., Thiele, L. S., Garcia, R. Tomas, Mugglestone, M. Topp, Torims, T., Torre, R., Tortora, L. T., Trifinopoulos, S., Udongwo, S. -A., Vai, I., Valente, R. U., van Rienen, U., van Weelderen, R., Vanwelde, M., Velev, G., Venditti, R., Vendrasco, A., Verna, A., Verweij, A., Verwilligen, P., Villamzar, Y., Vittorio, L., Vitulo, P., Vojskovic, I., Wang, D., Wang, L. -T., Wang, X., Wendt, M., Widorski, M., Wozniak, M., Wu, Y., Wulzer, A., Xie, K., Yang, Y., Yap, Y. C., Yonehara, K., Yoo, H. D., You, Z., Zanetti, M., Zaza, A., Zhang, L., Zhu, R., Zlobin, A., Zuliani, D., and Zurita, J. F.

Subjects
Physics - Accelerator Physics, High Energy Physics - Experiment
Abstract

The International Muon Collider Collaboration (IMCC) [1] was established in 2020 following the recommendations of the European Strategy for Particle Physics (ESPP) and the implementation of the European Strategy for Particle Physics-Accelerator R&D Roadmap by the Laboratory Directors Group [2], hereinafter referred to as the the European LDG roadmap. The Muon Collider Study (MuC) covers the accelerator complex, detectors and physics for a future muon collider. In 2023, European Commission support was obtained for a design study of a muon collider (MuCol) [3]. This project started on 1st March 2023, with work-packages aligned with the overall muon collider studies. In preparation of and during the 2021-22 U.S. Snowmass process, the muon collider project parameters, technical studies and physics performance studies were performed and presented in great detail. Recently, the P5 panel [4] in the U.S. recommended a muon collider R&D, proposed to join the IMCC and envisages that the U.S. should prepare to host a muon collider, calling this their "muon shot". In the past, the U.S. Muon Accelerator Programme (MAP) [5] has been instrumental in studies of concepts and technologies for a muon collider., Comment: This document summarises the International Muon Collider Collaboration (IMCC) progress and status of the Muon Collider R&D programme

Published
2024

2. An automated QC Station for the Calibration of the Mu2e Calorimeter Readout Units

Author

Sanzani, E., Bloise, C., Ceravolo, S., Cervelli, F., Colao, F., Cordelli, M., Corradi, G., Di Falco, S., Diociaiuti, E., Donati, S., Ferrari, C., Gargiulo, R., Gioiosa, A., Giovannella, S., Giusti, V., Hampai, D., Happacher, F., Martini, M., Miscetti, S., Morescalchi, L., Paesani, D., Pasciuto, D., Pedreschi, E., Raffaelli, F., Sarra, I., Saputi, A., Spinella, F., and Taffara, A.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The Mu2e calorimeter will employ Readout Units, each made of two Silicon Photomultipliers arrays and two Front End Electronics boards. To calibrate them, we have designed, assembled and put in operation an automated Quality Control (QC) station. Gain, collected charge and photon detection efficiency are evaluated for each unit. In this paper, the QC Station is presented, in its hardware and software aspects, summarizing also the tests performed on the ROUs and the first measurement results., Comment: To appear on NIM

Published
2022

4. An automated QC station for the calibration of the Mu2e calorimeter readout units

Author

Bloise, C., Ceravolo, S., Cervelli, F., Colao, F., Cordelli, M., Corradi, G., Falco, S. Di, Diociaiuti, E., Donati, S., Ferrari, C., Gargiulo, R., Gioiosa, A., Giovannella, S., Giusti, V., Hampai, D., Happacher, F., Martini, M., Miscetti, S., Morescalchi, L., Paesani, D., Pasciuto, D., Pedreschi, E., Raffaelli, F., Sanzani, E., Sarra, I., Saputi, A., Spinella, F., and Taffara, A.

Published
2023
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5. Design, assembly and operation of a Cosmic Ray Tagger based on scintillators and SiPMs

Author

Bloise, C., Ceravolo, S., Cervelli, F., Colao, F., Cordelli, M., Corradi, G., Di Falco, S., Diociaiuti, E., Donati, S., Ferrari, C., Gargiulo, R., Gioiosa, A., Giovannella, S., Giusti, V., Hampai, D., Happacher, F., Martini, M., Miscetti, S., Morescalchi, L., Paesani, D., Pasciuto, D., Pedreschi, E., Pierluigi, D., Raffaelli, F., Russo, A., Sanzani, E., Sarra, I., Saputi, A., Spinella, F., and Taffara, A.

Published
2023
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7. Research and Development Status for an Innovative Crystal Calorimeter for the Future Muon Collider

Author

Cantone, C., Ceravolo, S., Colao, F., Di Meco, E., Diociaiuti, E., Frank, I., Gianotti, P., Gargiulo, R., Leonardi, E., Lucchesi, D., Martellotti, S., Moulson, M., Paesani, D., Pastrone, N., Pezzullo, G., Saputi, A., Sarra, I., Sestini, L., and Tagnani, D.

Abstract

Accurate measurements of physical processes in high energy frontier experiments demand exceptional spatial, temporal, and energy precision to discern the physics behind high-energy particle jets. Calorimeters, like other detection systems, must be able to meet these increasingly challenging performance requirements. In the prospective TeV-scale Muon Collider, the primary hurdle in designing detectors and devising event reconstruction algorithms is the challenge posed by Beam-Induced Background (BIB). Nevertheless, it is conceivable to mitigate the impact of BIB on the Muon Collider’s calorimeter by capitalizing on certain characteristics and ensuring key features such as high granularity, precise timing, longitudinal segmentation, and superior energy resolution. This is what the here described Research and Development is trying to achieve with an innovative semi-homogeneous electromagnetic calorimeter constructed from stackable and interchangeable modules composed of lead fluoride crystals (PbF2). These modules are equipped with surface-mount UV-extended Silicon Photomultipliers (SiPMs) and are collectively referred to as the Crilin calorimeter (CRystal calorImeter with Longitudinal INformation). The challenge lies in making sure this calorimeter can operate effectively within an extremely harsh radiation environment, enduring an annual neutron flux of $10^{14}~n_{1\text {MeV}}/\text {cm}^{2}$ and a total ionizing dose (TID) of 10 kGy. In this article, the radiation tolerance measured in several irradiation campaigns is discussed, and the timing performances during a test beam at CERN-H2 with 120-GeV electrons. Additionally, a description of the latest prototype, Proto-1, is provided together with the results of the latest low-energy beam test at the LNF beam test facility (BTF) with 450 MeV electrons.

Published
2024
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8. An automated QC Station for the Calibration of the Mu2e Calorimeter Readout Units

Author

Bloise, C., Ceravolo, S., Cervelli, F., Colao, F., Cordelli, M., Corradi, G., Falco, S. D., Diociaiuti, E., Donati, S., Ferrari, C., Gargiulo, R., Gioiosa, A., Giovannella, S., Giusti, V., Hampai, D., Happacher, F., Martini, M., Miscetti, S., Morescalchi, L., Paesani, D., Pasciuto, D., Pedreschi, E., Raffaelli, F., Sanzani, E., Sarra, I., Saputi, A., Spinella, F., and Taffara, A.

Subjects
Nuclear and High Energy Physics, High Energy Physics - Experiment (hep-ex), Physics - Instrumentation and Detectors, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Instrumentation, High Energy Physics - Experiment
Abstract

The Mu2e calorimeter will employ Readout Units, each made of two Silicon Photomultipliers arrays and two Front End Electronics boards. To calibrate them, we have designed, assembled and put in operation an automated Quality Control (QC) station. Gain, collected charge and photon detection efficiency are evaluated for each unit. In this paper, the QC Station is presented, in its hardware and software aspects, summarizing also the tests performed on the ROUs and the first measurement results., To appear on NIM

Published
2022

9. Subjective Well-Being as an Indicator for Clinical Depression

Author

Gargiulo, R. and Stokes, Mark A.

Abstract

The Theory of Homeostasis posits that Subjective Well-being (SWB) is regulated by a dynamic biological mechanism, assisting to maintain a positive view of life. Further, the theory suggests that clinical depression is the loss of SWB due to the defeat of this homeostatic defence system. To test this hypothesis it was predicted that people who were diagnosed as clinically depressed with the Semi-structured Clinical Interview (SCID-1/NP) based on the "DSM-IV-TR" Axis 1 would have a Personal Well-being Index-Adult (PWI-A) score below the normative range (70-80% of scale maximum). Following ethical approval a sample of 146 men was obtained and each was assessed on the SCID-1/NP and on the PWI-A. Subjects diagnosed as having one of several pathologies such as post traumatic stress disorder, panic disorder, social phobia and specific phobia were found to score significantly lower on the PWI-A compared to participants who received no diagnosis. However, as the data did not discriminate between "currently depressed" and persons with "other non-depressive psychopathologies," a Receiver Operating Characteristics (ROC) curve analysis was used to explore this data further. Results indicated that the PWI-A was significantly better than guessing in discriminating clinically depressed cases, but only just so. Therefore, while this research found support for the proposition that the loss of SWB indicated clinical depression, the PWI-A is not sufficiently specific for diagnosis, nor can it be concluded that all instances of depression is the failure of SWB.

Published
2009
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11. Museums and communication channels: insights from social media choices

Author

Carignani F., Del Vacchio E., Gargiulo R., Laddaga C., Bifulco F., Carignani, F., Del Vacchio, E., Gargiulo, R., Laddaga, C., and Bifulco, F.

Subjects
Cultural tourism, social media, digitalization, engagement, digital marketing
Abstract

Purpose of the paper: The purpose of the work is to analyze the role of social media choices in communication channels of the cultural museums district. The paper focuses on how use their social and analytics’ tools in order to meet the needs of different targets before Covid-19. Methodology: We used a qualitative methodology, and we conducted an empirical investigation of multiple case studies (Yin, 1992): in particular, we chose evidence from the museum district of via Duomo in Naples, analyzing the eight cultural sites that compose it. Main Findings: Main findings show that the museums analyzed did not have a planned communication strategy (e.g. uniform content on all social platforms; publication of posts at wrong times, etc.) showing the lack of a common strategy of the district. Furthermore, the potential of foreign tourists is still little exploited and their presence on these pages is too marginal. Practical implications: Each cultural institution should use an integrated and planned strategy of digital communication. In particular, they should diversify their posts tailored to the main type of audience used by the single social media. Originality/value: This work offers a better understanding of the impact that digitalization and social media tools may have on cultural institutions.

Published
2021

15. Robots as service: acceptance or resistance

Author

Mele C., Russo Spena T., Tregua M., Gargiulo R., LADDAGA, CESARE, RANIERI, ANGELO, RUGGIERO, ANDREA, Mele C., Russo Spena T., Tregua M., Gargiulo R., Laddaga C., Ranieri A., Ruggiero A., Mele, C., Russo Spena, T., Tregua, M., Gargiulo, R., Laddaga, Cesare, Ranieri, Angelo, and Ruggiero, Andrea

Published
2019

17. Vascular Function Is Improved After an Environmental Enrichment Program

Author

Bruno, Rosa Maria, Stea, Francesco, Sicari, Rosa, Ghiadoni, Lorenzo, Taddei, Stefano, Ungar, Andrea, Bonuccelli, Ubaldo, Tognoni, Gloria, Cintoli, Simona, Del Turco, Serena, Sbrana, Silverio, Gargani, Luna, D'Angelo, Gennaro, Pratali, Lorenza, Berardi, Nicoletta, Maffei, Lamberto, Picano Eugenio, on behalf of Train the Brain Consortium. Full list of consortium members: Maffei L, Picano E, Andreassi MG, Angelucci A, Baldacci F, Baroncelli L, Begenisic T, Bellinvia PF, Berardi N, Biagi L, Bonaccorsi J, Bonanni E, Bonuccelli U, Borghini A, Braschi C, Broccardi M, Bruno RM, Caleo M, Carlesi C, Carnicelli L, Cartoni G, Cecchetti L, Cenni MC, Ceravolo R, Chico L, Cintoli S, Cioni G, Costa M, D’Angelo G, D’Ascanio P, De Nes M, Del Turco S, Di Coscio E, Di Galante M, di Lascio N, Faita F, Falorni I, Faraguna U, Fenu A, Fortunato L, Franco R, Gargani L, Gargiulo R, Ghiadoni L, Giorgi FS, Iannarella R, Iofrida C, Kusmic C, Limongi F, Maestri M, Maffei M, Maggi S, Mainardi M, Mammana L, Marabotti A, Mariotti V, Melissari E, Mercuri A, Molinaro S, Narducci R, Navarra T, Noale M, Pagni C, Palumbo S, Pasquariello R, Pellegrini S, Pietrini P, Pizzorusso T, Poli A, Pratali L, Retico A, Ricciardi E, Rota G, Sale A, Sbrana S, Scabia G, Scali M, Scelfo D, Sicari R, Siciliano G, Stea F, Taddei S, Tognoni G, Tonacci A, Tosetti M, Turchi S, Volpi L, Bruno, Rosa Maria, Stea, Francesco, Sicari, Rosa, Ghiadoni, Lorenzo, Taddei, Stefano, Ungar, Andrea, Bonuccelli, Ubaldo, Tognoni, Gloria, Cintoli, Simona, Del Turco, Serena, Sbrana, Silverio, Gargani, Luna, D'Angelo, Gennaro, Pratali, Lorenza, Berardi, Nicoletta, Maffei, Lamberto, Picano, Eugenio, on behalf of Train the Brain Consortium., Full list of consortium members: Maffei L, Picano, E, Andreassi, Mg, Angelucci, A, Baldacci, F, Baroncelli, L, Begenisic, T, Bellinvia, Pf, Berardi, N, Biagi, L, Bonaccorsi, J, Bonanni, E, Bonuccelli, U, Borghini, A, Braschi, C, Broccardi, M, Bruno, Rm, Caleo, M, Carlesi, C, Carnicelli, L, Cartoni, G, Cecchetti, L, Cenni, Mc, Ceravolo, R, Chico, L, Cintoli, S, Cioni, G, Costa, M, D’Angelo, G, D’Ascanio, P, De Nes, M, Del Turco, S, Di Coscio, E, Di Galante, M, di Lascio, N, Faita, F, Falorni, I, Faraguna, U, Fenu, A, Fortunato, L, Franco, R, Gargani, L, Gargiulo, R, Ghiadoni, L, Giorgi, F, Iannarella, R, Iofrida, C, Kusmic, C, Limongi, F, Maestri, M, Maffei, M, Maggi, S, Mainardi, M, Mammana, L, Marabotti, A, Mariotti, V, Melissari, E, Mercuri, A, Molinaro, S, Narducci, R, Navarra, T, Noale, M, Pagni, C, Palumbo, S, Pasquariello, R, Pellegrini, S, Pietrini, P, Pizzorusso, T, Poli, A, Pratali, L, Retico, A, Ricciardi, E, Rota, G, Sale, A, Sbrana, S, Scabia, G, Scali, M, Scelfo, D, Sicari, R, Siciliano, G, Stea, F, Taddei, S, Tognoni, G, Tonacci, A, Tosetti, M, Turchi, S, and Volpi, L

Subjects
Male, control groups, medicine.medical_specialty, Brachial Artery, Pulse Wave Analysis, 030204 cardiovascular system & hematology, 03 medical and health sciences, endothelial progenitor cell, 0302 clinical medicine, cognitive dysfunction, Internal medicine, medicine.artery, Internal Medicine, medicine, human, Brachial artery, Cognitive decline, humans, Pulse wave velocity, Aged, endothelial progenitor cells, Aged, 80 and over, Environmental enrichment, business.industry, control group, Area under the curve, Neuropsychology, Brain, vascular stiffness, Cognition, Middle Aged, medicine.disease, Exercise Therapy, Vasodilation, Cross-Sectional Studies, Cardiovascular Diseases, Cardiology, Female, Endothelium, Vascular, Alzheimer's disease, business, 030217 neurology & neurosurgery
Abstract

Environmental enrichment may slow cognitive decay possibly acting through an improvement in vascular function. Aim of the study was to assess the effects of a 7-month cognitive, social, and physical training program on cognitive and vascular function in patients with mild cognitive impairment. In a single-center, randomized, parallel-group study, 113 patients (age, 65–89 years) were randomized to multidomain training (n=55) or usual care (n=58). All participants underwent neuropsychological tests and vascular evaluation, including brachial artery flow-mediated dilation, carotid–femoral pulse wave velocity, carotid distensibility, and assessment of circulating hematopoietic CD34+ and endothelial progenitor cells. At study entry, an age-matched control group (n=45) was also studied. Compared with controls, patients had at study entry a reduced flow-mediated dilation (2.97±2.14% versus 3.73±2.06%; P =0.03) and hyperemic stimulus (shear rate area under the curve, 19.1±15.7 versus 25.7±15.1×10 −3 ; P =0.009); only the latter remained significant after adjustment for confounders ( P =0.03). Training improved Alzheimer disease assessment scale cognitive (training, 14.0±4.8 to 13.1±5.5; nontraining, 12.1±3.9 to 13.2±4.8; P for interaction visit×training=0.02), flow-mediated dilation (2.82±2.19% to 3.40±1.81%, 3.05±2.08% to 2.24±1.59%; P =0.006; P =0.023 after adjustment for diameter and shear rate area under the curve), and circulating hematopoietic CD34 + cells and prevented the decline in carotid distensibility (18.4±5.3 to 20.0±6.6, 23.9±11.0 to 19.5±7.1 Pa −1 ; P =0.005). The only clinical predictor of improvement of cognitive function after training was established hypertension. There was no correlation between changes in measures of cognitive and vascular function. In conclusion, a multidomain training program slows cognitive decline, especially in hypertensive individuals. This effect is accompanied by improved systemic endothelial function, mobilization of progenitor CD34 + cells, and preserved carotid distensibility. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT01725178.

Published
2018

20. Crop wild phylorelatives (CWPs): phylogenetic distance, cytogenetic compatibility and breeding system data enable estimation of crop wild relative gene pool classification

Author

Viruel, J., Kantar, M.B., Gargiulo, R., Hesketh-Prichard, P., Leong, N., Cockel, C., Forest, F., Gravendeel, B., Pérez-Barrales, R., Leitch, I.J., Wilkin, P., Viruel, J., Kantar, M.B., Gargiulo, R., Hesketh-Prichard, P., Leong, N., Cockel, C., Forest, F., Gravendeel, B., Pérez-Barrales, R., Leitch, I.J., and Wilkin, P.

Abstract

Contains fulltext : 229139.pdf (publisher's version ) (Closed access)

Published
2021

21. Brain Hemodynamic Intermediate Phenotype Links Vitamin B12 to Cognitive Profile of Healthy and Mild Cognitive Impaired Subjects

Author

Cecchetti L., Lettieri G., Handjaras G., Leo A., Ricciardi E., Pietrini P., Pellegrini S., Andreassi M. G., Angelucci A., Baldacci F., Baroncelli L., Begenisic T., Bellinvia P. F., Biagi L., Bonaccorsi J., Bonanni E., Borghini A., Braschi C., Broccardi M., Caleo M., Carlesi C., Carnicelli L., Cartoni G., Cenni M. C., Ceravolo R., Chico L., Cioni G., Costa M., D'Ascanio P., De Nes M., Di Coscio E., Di Galante M., di Lascio N., Faita F., Falorni I., Faraguna U., Fenu A., Fortunato L., Franco R., Gargiulo R., Giorgi F. S., Iannarella R., Iofrida C., Kusmic C., Limongi F., Maestri M., Maffei M., Maggi S., Mainardi M., Mammana L., Marabotti A., Mariotti V., Melissari E., Mercuri A., Molinaro S., Narducci R., Navarra T., Noale M., Pagni C., Palumbo S., Pasquariello R., Pizzorusso T., Poli A., Retico A., Rota G., Sale A., Scabia G., Scali M., Scelfo D., Siciliano G., Tonacci A., Tosetti M., Turchi S., Volpi L., Cecchetti, L., Lettieri, G., Handjaras, G., Leo, A., Ricciardi, E., Pietrini, P., Pellegrini, S., Andreassi, M. G., Angelucci, A., Baldacci, F., Baroncelli, L., Begenisic, T., Bellinvia, P. F., Biagi, L., Bonaccorsi, J., Bonanni, E., Borghini, A., Braschi, C., Broccardi, M., Caleo, M., Carlesi, C., Carnicelli, L., Cartoni, G., Cenni, M. C., Ceravolo, R., Chico, L., Cioni, G., Costa, M., D'Ascanio, P., De Nes, M., Di Coscio, E., Di Galante, M., di Lascio, N., Faita, F., Falorni, I., Faraguna, U., Fenu, A., Fortunato, L., Franco, R., Gargiulo, R., Giorgi, F. S., Iannarella, R., Iofrida, C., Kusmic, C., Limongi, F., Maestri, M., Maffei, M., Maggi, S., Mainardi, M., Mammana, L., Marabotti, A., Mariotti, V., Melissari, E., Mercuri, A., Molinaro, S., Narducci, R., Navarra, T., Noale, M., Pagni, C., Palumbo, S., Pasquariello, R., Pizzorusso, T., Poli, A., Retico, A., Rota, G., Sale, A., Scabia, G., Scali, M., Scelfo, D., Siciliano, G., Tonacci, A., Tosetti, M., Turchi, S., and Volpi, L.

Subjects
Vitamin, Male, medicine.medical_specialty, Article Subject, Homocysteine, Brain activity and meditation, Longitudinal Studie, Settore BIO/09 - Fisiologia, lcsh:RC321-571, Cohort Studies, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cognition, Neuroimaging, Internal medicine, medicine, Humans, Cognitive Dysfunction, Vitamin B12, Hemodynamic, Longitudinal Studies, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Anterior cingulate cortex, 030304 developmental biology, Aged, Aged, 80 and over, 0303 health sciences, business.industry, Neuropsychology, Hemodynamics, Brain, Vitamin B 12, medicine.anatomical_structure, Endocrinology, Phenotype, Neurology, chemistry, Female, Neurology (clinical), Cohort Studie, business, 030217 neurology & neurosurgery, Human, Research Article
Abstract

Vitamin B12, folate, and homocysteine are implicated in pivotal neurodegenerative mechanisms and partake in elders' mental decline. Findings on the association between vitamin-related biochemistry and cognitive abilities suggest that the structural and functional properties of the brain may represent an intermediate biomarker linking vitamin concentrations to cognition. Despite this, no previous study directly investigated whether vitamin B12, folate, and homocysteine levels are sufficient to explain individual neuropsychological profiles or, alternatively, whether the activity of brain regions modulated by these compounds better predicts cognition in elders. Here, we measured the relationship between vitamin blood concentrations, scores at seventeen neuropsychological tests, and brain activity of sixty-five elders spanning from normal to Mild Cognitive Impairment. We then evaluated whether task-related brain responses represent an intermediate phenotype, providing a better prediction of subjects' neuropsychological scores, as compared to the one obtained considering blood biochemistry only. We found that the hemodynamic activity of the right dorsal anterior cingulate cortex was positively associated (p value < 0 05 cluster corrected) with vitamin B12 concentrations, suggesting that elders with higher B12 levels had a more pronounced recruitment of this salience network region. Crucially, the activity of this area significantly predicted subjects' visual search and attention abilities (p value = 0 0023), whereas B12 levels per se failed to do so. Our results demonstrate that the relationship between blood biochemistry and elders' cognitive abilities is revealed when brain activity is included into the equation, thus highlighting the role of brain imaging as intermediate phenotype. Vitamin B12, folate, and homocysteine are implicated in pivotal neurodegenerative mechanisms and partake in elders' mental decline. Findings on the association between vitamin-related biochemistry and cognitive abilities suggest that the structural and functional properties of the brain may represent an intermediate biomarker linking vitamin concentrations to cognition. Despite this, no previous study directly investigated whether vitamin B12, folate, and homocysteine levels are sufficient to explain individual neuropsychological profiles or, alternatively, whether the activity of brain regions modulated by these compounds better predicts cognition in elders. Here, we measured the relationship between vitamin blood concentrations, scores at seventeen neuropsychological tests, and brain activity of sixty-five elders spanning from normal to Mild Cognitive Impairment. We then evaluated whether task-related brain responses represent an intermediate phenotype, providing a better prediction of subjects' neuropsychological scores, as compared to the one obtained considering blood biochemistry only. We found that the hemodynamic activity of the right dorsal anterior cingulate cortex was positively associated (p value < 0 05 cluster corrected) with vitamin B12 concentrations, suggesting that elders with higher B12 levels had a more pronounced recruitment of this salience network region. Crucially, the activity of this area significantly predicted subjects' visual search and attention abilities (p value = 0 0023), whereas B12 levels per se failed to do so. Our results demonstrate that the relationship between blood biochemistry and elders' cognitive abilities is revealed when brain activity is included into the equation, thus highlighting the role of brain imaging as intermediate phenotype.

Published
2019

23. Effects of combined training on neuropsychiatric symptoms and quality of life in patients with cognitive decline

Author

Cintoli, S., Radicchi, C., Noale, M., Maggi, S., Meucci, G., Tognoni, G., Bonuccelli, U., Sale, A., Berardi, N., Maffei, L., Picano, E., Andreassi, M. G., Angelucci, A., Baldacci, F., Baroncelli, L., Begenisic, T., Bellinvia, P. F., Biagi, L., Bonaccorsi, J., Bonanni, E., Borghini, A., Braschi, C., Broccardi, M., Bruno, R. M., Caleo, M., Carlesi, C., Carnicelli, L., Cartoni, G., Cecchetti, L., Cenni, M. C., Ceravolo, R., Chico, L., Cioni, G., Coscia, M., Costa, M., D'Angelo, G., D'Ascanio, P., Denes, M., Delturco, S., Dicoscio, E., Digalante, M., Dilascio, N., Faita, F., Falorni, I., Faraguna, U., Fenu, A., Fortunato, L., Franco, R., Gargani, L., Gargiulo, R., Ghiadoni, L., Giorgi, F. S., Iannarella, R., Iofrida, C., Kusmic, C., Limongi, F., Maestri, M., Maffei, M., Mainardi, M., Mammana, L., Marabotti, A., Mariotti, V., Melissari, E., Mercuri, A., Micera, S., Molinaro, S., Narducci, R., Navarra, T., Pagni, C., Palumbo, S., Pasquariello, R., Pellegrini, S., Pietrini, P., Pizzorusso, T., Poli, A., Pratali, L., Retico, A., Ricciardi, E., Rota, G., Sbrana, S., Scabia, G., Scali, M., Scelfo, D., Sicari, R., Siciliano, G., Stea, F., Taddei, S., Tonacci, A., Tosetti, M., Turchi, S., Volpi, L., Cintoli, S., Radicchi, C., Noale, M., Maggi, S., Meucci, G., Tognoni, G., Bonuccelli, U., Sale, A., Berardi, N., Maffei, L., Picano, E., Andreassi, M. G., Angelucci, A., Baldacci, F., Baroncelli, L., Begenisic, T., Bellinvia, P. F., Biagi, L., Bonaccorsi, J., Bonanni, E., Borghini, A., Braschi, C., Broccardi, M., Bruno, R. M., Caleo, M., Carlesi, C., Carnicelli, L., Cartoni, G., Cecchetti, L., Cenni, M. C., Ceravolo, R., Chico, L., Cioni, G., Coscia, M., Costa, M., D'Angelo, G., D'Ascanio, P., Denes, M., Delturco, S., Dicoscio, E., Digalante, M., Dilascio, N., Faita, F., Falorni, I., Faraguna, U., Fenu, A., Fortunato, L., Franco, R., Gargani, L., Gargiulo, R., Ghiadoni, L., Giorgi, F. S., Iannarella, R., Iofrida, C., Kusmic, C., Limongi, F., Maestri, M., Maffei, M., Mainardi, M., Mammana, L., Marabotti, A., Mariotti, V., Melissari, E., Mercuri, A., Micera, S., Molinaro, S., Narducci, R., Navarra, T., Pagni, C., Palumbo, S., Pasquariello, R., Pellegrini, S., Pietrini, P., Pizzorusso, T., Poli, A., Pratali, L., Retico, A., Ricciardi, E., Rota, G., Sbrana, S., Scabia, G., Scali, M., Scelfo, D., Sicari, R., Siciliano, G., Stea, F., Taddei, S., Tonacci, A., Tosetti, M., Turchi, S., and Volpi, L.

Subjects
Quality of life, medicine.medical_specialty, Aging, education, Psychological intervention, Neuropsychiatric symptom, Disease, Neuropsychological Tests, Settore BIO/09 - Fisiologia, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, mental disorders, Medicine, Dementia, Humans, Mild cognitive impairment, Neuropsychiatric symptoms, Non-pharmacological interventions, Physical and cognitive training, In patient, Cognitive Dysfunction, 030212 general & internal medicine, Cognitive decline, Aged, business.industry, Non-pharmacological intervention, Cognition, medicine.disease, Cognitive training, humanities, Physical therapy, Neuropsychological Test, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Human
Abstract

Background and aims: Cognitive impairments associated with aging and dementia are major sources of neuropsychiatric symptoms (NPs) and deterioration in quality of life (QoL). Preventive measures to both reduce disease and improve QoL in those affected are increasingly targeting individuals with mild cognitive impairment (MCI) at early disease stage. However, NPs and QoL outcomes are too commonly overlooked in intervention trials. The purpose of this study was to test the effects of physical and cognitive training on NPs and QoL in MCI. Methods: Baseline data from an MCI court (N = 93, mean age 74.9 ± 4.7) enrolled in the Train the Brain (TtB) study were collected. Subjects were randomized in two groups: a group participated to a cognitive and physical training program, while the other sticked to usual standard care. Both groups underwent a follow-up re-evaluation after 7months from baseline. NPs were assessed using the Neuropsychiatric Inventory (NPI) and QoL was assessed using Quality of Life-Alzheimer’s Disease (QOL-AD) scale. Results: After 7months of training, training group exhibited a significant reduction of NPs and a significant increase in QOL-AD with respect to no-training group (p = 0.0155, p = 0.0013, respectively). Our preliminary results suggest that a combined training can reduce NPs and improve QoL. Conclusions: Measuring QoL outcomes is a potentially important factor in ensuring that a person with cognitive deficits can ‘live well’ with pathology. Future data from non-pharmacological interventions, with a larger sample and a longer follow-up period, could confirm the results and the possible implications for such prevention strategies for early cognitive decline. Background and aims: Cognitive impairments associated with aging and dementia are major sources of neuropsychiatric symptoms (NPs) and deterioration in quality of life (QoL). Preventive measures to both reduce disease and improve QoL in those affected are increasingly targeting individuals with mild cognitive impairment (MCI) at early disease stage. However, NPs and QoL outcomes are too commonly overlooked in intervention trials. The purpose of this study was to test the effects of physical and cognitive training on NPs and QoL in MCI. Methods: Baseline data from an MCI court (N = 93, mean age 74.9 ± 4.7) enrolled in the Train the Brain (TtB) study were collected. Subjects were randomized in two groups: a group participated to a cognitive and physical training program, while the other sticked to usual standard care. Both groups underwent a follow-up re-evaluation after 7 months from baseline. NPs were assessed using the Neuropsychiatric Inventory (NPI) and QoL was assessed using Quality of Life-Alzheimer’s Disease (QOL-AD) scale. Results: After 7 months of training, training group exhibited a significant reduction of NPs and a significant increase in QOL-AD with respect to no-training group (p = 0.0155, p = 0.0013, respectively). Our preliminary results suggest that a combined training can reduce NPs and improve QoL. Conclusions: Measuring QoL outcomes is a potentially important factor in ensuring that a person with cognitive deficits can ‘live well’ with pathology. Future data from non-pharmacological interventions, with a larger sample and a longer follow-up period, could confirm the results and the possible implications for such prevention strategies for early cognitive decline.

Published
2019

24. An inter-laboratory comparison to evaluate the suitability of EN 1787 standard to detect irradiation in plant-origin foods with health benefits

Author

Bortolin, E., primary, Cardamone, C., additional, Chiaravalle, A.E., additional, Carratù, B., additional, Deiana, G., additional, Di Noto, A., additional, Di Schiavi, M.T., additional, D'Oca, M.C., additional, Gargiulo, R., additional, Mangiacotti, M., additional, Marchesani, G., additional, Quattrini, M.C., additional, Tomaiuolo, M., additional, and Boniglia, C., additional

Published
2020
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28. Le deduzioni difensive della parte M.B. nel procedimento giudiziale dinanzi alla Corte di Giustizia

Author

Amalfitano, C, Andreazza, G, Bin, R, Caianiello, M, D'Amico, M, De Bellis, G, Di Bucci, V, Di Federico, G, Donini, M, Gallo, D, Gargiulo, R, Insolera, P, Lupo, E, Manes, V, Marciano, A, Mastroianni, R, Mazzacuva, F, Quattrocolo, S, Randazzo, B, Riccardi, G, Rossi, LS, Zeno-Zencovich, V, Amalfitano, C, Andreazza, G, Bin, R, Caianiello, M, D'Amico, M, De Bellis, G, Di Bucci, V, Di Federico, G, Donini, M, Gallo, D, Gargiulo, R, Insolera, P, Lupo, E, Manes, V, Marciano, A, Mastroianni, R, Mazzacuva, F, Quattrocolo, S, Randazzo, B, Riccardi, G, Rossi, LS, and Zeno-Zencovich, V

Published
2018

29. Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study

Author

Maffei, L., Picano, E., Andreassi, M. G., Angelucci, A., Baldacci, F., Baroncelli, L., Begenisic, T., Bellinvia, P. F., Berardi, N., Biagi, L., Bonaccorsi, J., Bonanni, E., Bonuccelli, U., Borghini, A., Braschi, C., Broccardi, M., Bruno, R. M., Caleo, M., Carlesi, C., Carnicelli, L., Cartoni, G., Cecchetti, L., Cenni, M. C., Ceravolo, R., Chico, L., Cintoli, S., Cioni, G., Coscia, M., Costa, M., D’Angelo, G., D’Ascanio, P., Nes, M. De, Turco, S. Del, Coscio, E. Di, Galante, M. Di, Lascio, N. di, Faita, F., Falorni, I., Faraguna, U., Fenu, A., Fortunato, L., Franco, R., Gargani, L., Gargiulo, R., Ghiadoni, L., Giorgi, F. S., Iannarella, R., Iofrida, C., Kusmic, C., Limongi, F., Maestri, M., Maffei, M., Maggi, S., Mainardi, Marco, Mammana, L., Marabotti, A., Mariotti, V., Melissari, E., Mercuri, A., Micera, S., Molinaro, S., Narducci, R., Navarra, T., Noale, M., Pagni, C., Palumbo, S., Pasquariello, R., Pellegrini, S., Pietrini, P., Pizzorusso, T., Poli, A., Pratali, L., Retico, A., Ricciardi, E., Rota, G., Sale, A., Sbrana, S., Scabia, G., Scali, M., Scelfo, D., Sicari, R., Siciliano, G., Stea, F., Taddei, S., Tognoni, G., Tonacci, A., Tosetti, M., Turchi, S., Volpi, L., Mainardi, Marco (ORCID:0000-0003-2001-1287), Maffei, L., Picano, E., Andreassi, M. G., Angelucci, A., Baldacci, F., Baroncelli, L., Begenisic, T., Bellinvia, P. F., Berardi, N., Biagi, L., Bonaccorsi, J., Bonanni, E., Bonuccelli, U., Borghini, A., Braschi, C., Broccardi, M., Bruno, R. M., Caleo, M., Carlesi, C., Carnicelli, L., Cartoni, G., Cecchetti, L., Cenni, M. C., Ceravolo, R., Chico, L., Cintoli, S., Cioni, G., Coscia, M., Costa, M., D’Angelo, G., D’Ascanio, P., Nes, M. De, Turco, S. Del, Coscio, E. Di, Galante, M. Di, Lascio, N. di, Faita, F., Falorni, I., Faraguna, U., Fenu, A., Fortunato, L., Franco, R., Gargani, L., Gargiulo, R., Ghiadoni, L., Giorgi, F. S., Iannarella, R., Iofrida, C., Kusmic, C., Limongi, F., Maestri, M., Maffei, M., Maggi, S., Mainardi, Marco, Mammana, L., Marabotti, A., Mariotti, V., Melissari, E., Mercuri, A., Micera, S., Molinaro, S., Narducci, R., Navarra, T., Noale, M., Pagni, C., Palumbo, S., Pasquariello, R., Pellegrini, S., Pietrini, P., Pizzorusso, T., Poli, A., Pratali, L., Retico, A., Ricciardi, E., Rota, G., Sale, A., Sbrana, S., Scabia, G., Scali, M., Scelfo, D., Sicari, R., Siciliano, G., Stea, F., Taddei, S., Tognoni, G., Tonacci, A., Tosetti, M., Turchi, S., Volpi, L., and Mainardi, Marco (ORCID:0000-0003-2001-1287)

Abstract

Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness and action mechanisms of physical/cognitive training in elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We assessed in 113 MCI subjects aged 65-89 years, the efficacy of combined physical-cognitive training on cognitive decline, Gray Matter (GM) volume loss and Cerebral Blood Flow (CBF) in hippocampus and parahippocampal areas, and on brain-blood-oxygenation-level-dependent (BOLD) activity elicited by a cognitive task, measured by ADAS-Cog scale, Magnetic Resonance Imaging (MRI), Arterial Spin Labeling (ASL) and fMRI, respectively, before and after 7 months of training vs. usual life. Cognitive status significantly decreased in MCI-no training and significantly increased in MCI-training subjects; training increased parahippocampal CBF, but no effect on GM volume loss was evident; BOLD activity increase, indicative of neural efficiency decline, was found only in MCI-no training subjects. These results show that a non pharmacological, multicomponent intervention improves cognitive status and indicators of brain health in MCI subjects.

Published
2017

30. DOSimetria in Situazioni di Emergenza Radiologica (DOSSIER)

Author

MARRALE, Maurizio, BARTOLOTTA, Antonio, BASILE, Salvatore, BRAI, Maria, D'OCA, Maria Cristina, LONGO, Anna, TRANCHINA, Luigi, Boniglia, C, Bortolin, E, Buttafava, A, Colone, M, De Angelis, C, Della Monaca, S, Dondi, D, Fattibene, P, Faucitano, A, Gargiulo, R, Molinari, A, Stringaro, A, Viscomi, D., MARRALE, M, Bartolotta, A, Basile, S, Boniglia, C, Bortolin, E, Brai, M, Buttafava, A, Colone, M, De Angelis, C, Della Monaca, S, D'Oca, MC, Dondi, D, Fattibene, P, Faucitano, A, Gargiulo, R, Longo, A, Molinari, A, Stringaro, A, Tranchina, L, and Viscomi, D

Subjects
Dosimetria accidentale, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Published
2010

32. Epidemic diffusion of KPC carbapenemase-producing Klebsiella pneumoniae in Italy: results of the first countrywide survey, 15 May to 30 June 2011

Author

Giani, T, Pini, B, Arena, F, Conte, V, Bracco, S, Migliavacca, R, Pantosti, A, Pagani, L, Luzzaro, F, M Rossolini, G, Vismara, C, Colombo, A, Serra, R, Kroumova, V, Mori, M, A Dusi, P, Mazzariol, A, Pagani, E, Gargiulo, R, Venturelli, C, Pecile, P, Mencacci, A, Manso, E, Tronci, M, Fazii, P, Labonia, M, Pizzolante, M, Amato, G, Buonopane, G, Cavalcanti, P, G Conaldi, P, Stefani, S, and F Di Vincenzo

Subjects
Infection Control, KPC carbapenemase, Colony Count, Microbial, Microbial Sensitivity Tests, Laboratories, Hospital, beta-Lactamases, Klebsiella Infections, Specimen Handling, Klebsiella pneumoniae, Cross-Sectional Studies, Bacterial Proteins, Carbapenems, Italy, Drug Resistance, Multiple, Bacterial, Humans
Abstract

Carbapenem-resistant Enterobacteriaceae (CRE) are emerging as a public health problem in various settings. In Italy, a rapid and remarkable increase of carbapenem-non-susceptible Klebsiella pneumoniae has been reported since 2010. Here we report on the results of a countrywide cross-sectional survey, carried out from 15 May to 30 June 2011 to investigate the diffusion of CRE in Italy and to characterise the most prevalent resistance mechanisms and their dissemination patterns. CRE were reported from most (23 of 25) participating laboratories, with an overall proportion of 3.5% and 0.3% among consecutive non-duplicate clinical isolates of Enterobacteriaceae from inpatients (n=7,154) and outpatients (n=6,595), respectively. K. pneumoniae was the most frequent species (proportion of carbapenem-non-susceptible isolates: 11.9%), while a minority of CRE of other species were detected. Carbapenemase production was detected in the majority (85%) of CRE. KPC-type enzymes were by far the most common (89.5% of carbapenemase producers), followed by VIM-1 (9.2%) and OXA-48 (1.3%). KPC-producing K. pneumoniae (KPC-KP) were detected in most centres and contributed majorly to the epidemic dissemination of CRE recently observed in our country. Dissemination of KPC-KP was mostly sustained by strains of clonal complex 258 (ST-258 producing KPC-2 or KPC-3, and ST-512 producing KPC-3), while a minority belonged to ST-101.

Published
2013

33. Accuracy of automated and manual systems for susceptibility testing of Pseudomonas aeruginosa to piperacillin and piperacillin-tazobactam

Author

Gagliotti, C., Sarti, M., Sabia, C., Gargiulo, R., Rossolini, G. M., Carillo, C., Cassani, C., Cipolloni, A. P., Pedna, F., Rossi, M. R., Incerti, S. S., Testa, G., Venturelli, C., and Maria Luisa Moro

Subjects
Piperacillin, Bacteriological Techniques, antibiotic resistance, Piperacillin, Tazobactam Drug Combination, Predictive Value of Tests, Pseudomonas aeruginosa, pseudomonas. automated system, Humans, Penicillanic Acid, Pseudomonas Infections, Microbial Sensitivity Tests, Anti-Bacterial Agents
Abstract

This study aimed to evaluate the accuracy of routine systems (Vitek2 cards AST-N022 and AST-N026; Kirby Bauer; Etest) for susceptibility testing of Pseudomonas aeruginosa to piperacillin and piperacillin-tazobactam. Vitek2 (card AST-N022) showed the worst performance; the other three methods (Vitek2 card AST-N026, Kirby-Bauer and E-test) performed comparably but never fulfilled the minimal standard proposed by FDA.

Published
2010

34. Asperula calabra (Rubiaceae) and allied taxa in southern Apennines, Italy.

Author

Del Guacchio, E., Gargiulo, R., and Caputo, P.

Subjects
*WOODRUFF, *RUBIACEAE, *GENTIANALES, *MOUNTAINS
Abstract

The present work is aimed at studying severalAsperula(Rubiaceae) sect.Cynanchicaepopulations in southern Apennines, Italy, with particular reference to those referred toA. calabra, by employing biometrical methods on macromorphological data. Among other historical misapplications,A. cynanchicasubsp.cynanchicaseems to be very rare or missing in southern Italy. The enigmaticAsperula calabra, confirmed to be limited to a single mountain population in Calabria, appears to be strictly related toA. aristatasubsp.scabra, so we suggest to treat it as a further subspecies ofA. aristata. This latter species is otherwise distributed throughout southern Italy with subsp.scabraand subsp.aristata, characterised by slight morphological differences, which are correlated to altitudinal ranges. [ABSTRACT FROM PUBLISHER]

Published
2017
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38. P53 NEISSERIA GONORRHOEAE INFECTIVE ENDOCARDITIS. A CASE REPORT

Author

Querci, M., primary, Rombini, F., additional, Espinola, L., additional, Boutureira, M., additional, Yetman, M., additional, Reyes, D., additional, Solis, C., additional, Gargiulo, R., additional, Galarza, P., additional, Muzzio, M., additional, Lamelas, A., additional, Coronel, R., additional, Guastavino, D., additional, Lambertini, R., additional, and Nacinovich, F., additional

Published
2013
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47. Mu2e Run I Sensitivity Projections for the Neutrinoless $\mu^- \to e^-$ Conversion Search in Aluminum

Author

Abdi, F., Abrams, R., Adentunji, J., Ahmed, W., Alber, R., Alexander, D., Allen, D., Allspach, D., Alvarez-Garcia, C., Ambrose, D., Ambrosio, G., Amirkhanov, A., Andreev, N., Ankenbrandt, C. M., Appleby, R., Arnold, D., Artikov, A., Atanov, N., Badgley, K., Ball, M., Baranov, V., Barker, J., Barnes, E., Barton, B., Bartoszek, L., Bellettini, G., Bernstein, R. H., Bersani, A., Bianchi, I., Biery, K., Bini, S., Blazey, G., Bloise, C., Boedigheimer, K., Boi, S., Bolton, T., Bono, J., Bonventre, R., Borghi, S., Borrel, L., Bossert, R., Bowcock, T., Bowden, M., Brandt, J., Breach, M., Brown, D., Brown, D. N., Brown, G., Brown, H., Budagov, I., Buelher, M., Bulugean, G. -M, Byrum, K., Campbell, M., Cao, H., Carey, R. M., Caron, J. F., Casey, B., Casler, H., Cervelli, F., Cheban, S., Chen, J., Chen, M., Cheng, C. -H, Chislett, R., Chitirasreemadam, N., Chokheli, D., Ciampa, K., Ciolini, R., Coghill, J., Colao, F., Coleman, R. N., Corrodi, S., Crescimbeni, L., Crowley, C., Culbertson, R., Cummings, M. A. C., Daniel, A., Davydov, Y., Demers, S., Deshpande, A., Devilbiss, M., Dey, J., Felice, G., Gouvea, A., Dhanraj, J., Ding, D., Dinnon, M., Diociaiuti, E., Dixon, S., Di Falco, S., Djilkibaev, R., Donati, S., Drake, G., Drendel, B., Duerling, G., Dukes, E. C., Dychkant, A., Echenard, B., Eddy, N., Edmonds, A., Ehrlich, R., Ekka, U., Evans, R., Evbota, D., Fabbricatore, P., Fagan, J., Farinon, S., Farrell, W., Farris, P., Feher, S., Fellenz, B., Fernandez, E., Ferrari, A., Ferrari, C., Finley, J., Flood, K., Flumerfelt, E., Fontana, F., Francis, K., Frand, M., Frank, M., Friedsam, H., Gallo, G., Gandrajula, R. P., Gaponenko, A., Gardner, M., Gargiulo, R., Gaugel, S., Genser, K. L., Gersabeck, M., Ginther, G., Gioiosa, A., Giovannella, S., Giusti, V., Glagolev, V., Glass, H., Glenzinski, D. A., Goadhouse, S., Goodenough, L., Grancagnolo, F., Gray, P., Group, C., Hahn, A., Hampai, D., Hansen, S., Happacher, F., Harkness-Brennan, L., Harrig, K., Hartsell, B., Hays, S., Hedges, M., Hedin, D., Heller, K., Herman, A., Hirsh, S., Hitlin, D. G., Hocker, A., Hooper, R., Horton-Smith, G., Huang, S., Huedem, E., Huffman, D., Hung, P. Q., Hungerford, E., Ibrahim, A., Israel, S., Jenkins, M., Johnstone, C., Jones, M., Jorjadze, V., Judson, D., Kampa, C., Kargiantoulakis, M., Kashikhin, V., Kasper, P., Keshavarzi, A., Khalatian, V., Kim, J. -H, Kiper, T., Knapp, D., Knodel, O., Knoepfel, K., Kokosa, L., Kolomensky, Yu G., Koltick, D., Kozlovsky, M., Kozminski, J., Kracczyk, G., Kramp, M., Krave, S., Krempetz, K., Kutschke, R. K., Kwarciany, R., Lackowski, T., Lamm, M. J., Lancaster, M., Larwill, M., Leavell, F., Lee, M. J., Leeb, D., Lema-Sinchi, J., Leveling, T., Lewis, R., Ley, A., Li, B., Li, Y., Lin, D., Lincoln, D., Logashenko, I., Lombardo, V., Lopes, M. L., Luca, A., Lynch, K. R., Mackenzie, M., Makulski, A., Manolis, J., Maravin, Yu, Marciano, W. J., Marini, A., Martin, E., Martinez, A., Martini, M., Mcarthur, D., Mcconologue, F., Mesmer, N., Messerly, B., Michelotti, L., Middleton, S., Miles, C., Miller, J. P., Nguyen, T. M., Miscetti, S., Mitchell, D., Miyashita, T., Mokhov, N., Molenaar, D., Molzon, W., Moore, J., Morescalchi, L., Morgan, J., Mott, J., Motuk, E., Mueller, S., Mukherjee, A., Murat, P., Musenich, R., Nagaslaev, V., Narayanan, A., Neely, R., Neuffer, D. V., Nguyen, M. T., Nicol, T., Niehoff, J., Nogiec, J., Norman, A., Northrup, K., O, V., Oh, S., Oksuzian, Yu, Olderr, P., Olson, M., Orris, D., Oshinowo, B., Ostojic, R., Oyang, J., Paesani, D., Pagan, S., Page, T., Palladino, A., Park, C., Pasciuto, D., Pedreschi, E., Peterson, T., Pezzullo, G., Pilipenko, R., Pla-Dalmau, A., Plesniak, P., Pohlman, N., Pollack, B., Poloubotko, V., Popovic, M., Popp, J. L., Frank C. Porter, Prebys, E. J., Price, J., Prieto, P., Pronskikh, V., Pushka, D., Quirk, J., Rabehl, R., Rachamin, R., Raffaelli, F., Ragheb, A., Rakness, G., Ray, R. E., Rechenmacher, R., Rivera, R., Rizzo, G., Roberts, B. L., Roberts, S., Roberts, T. J., Robotham, W., Roehrken, M., Rubinov, P., Rucinski, R., Rusu, V. L., Samavat, M. F., Sanzani, E., Saputi, A., Sarra, I., Sarychev, M., Scarpine, V., Schappert, W., Schmitt, M., Schmitter, P., Schoo, D., Schumacher, K., Shi, X., Singh, V., Sobering, T., Soleti, R., Solt, M., Song, H., Song, E., Spinella, F., Srivastav, M., Stefanik, A., Stetzler, S., Still, D., Stortini, M., Stratakis, D., Strauss, T., Sun, Y., Suslov, I., Syphers, M. J., Szemraj, L., Ta, J., Taffara, A., Tang, Z., Tanovic, N., Tartaglia, M., Tassielli, G., Taylor, R., Tecchio, M., Tickle, S., Tinsley, D., Tope, T., Torkelson, A., Tran, N., Trevor, J., Tschirhart, R. S., Turnberg, S., Uzunyan, S., Varier, D., Velasco, M., Vinas, L., Vitali, B., Vogel, G., Wagner, R., Wands, R., Wang, Y., Wang, C., Wang, M., Wardlaw, I., Warren, M., Werkema, S., White, Jr H. B., 11, J., Whitmore, J., Wielgos, R., Wildberger, R., Wills, L., Winter, P., Woods, R., Worel, C., Wu, Y., Xia, L., You, Z., Yucel, M., Zadeh, P., Zanetti, A. M., Zhadan, D., Zhu, R. -Y, Zifko, R., and Zutshi, V.

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