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7. Real-world effectiveness of long acting aripiprazole: Treatment persistence and its correlates in the Italian clinical practice

Author

Fagiolini, A., Aguglia, E., Ballerini, A., Callista, G., Carpiniello, B., Clerici, M., Corrivetti, G., De Fazio, P., De Filippis, S., De Giorgi, S., Favaretto, G., Ferri, E., Gargiulo, G., Giustra, M.G., La Barbera, D., Maina, G., Mencacci, C., Montagnani, G., Panariello, A., Pigato, G., Tortorella, A., Vernacotola, L., and Vita, A.

Published
2019
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10. Wide Field Imaging. I. Applications of Neural Networks to object detection and star/galaxy classification

Author

Andreon, S., Gargiulo, G., Longo, G., Tagliaferri, R., and Capuano, N.

Subjects
Astrophysics
Abstract

[Abriged] Astronomical Wide Field Imaging performed with new large format CCD detectors poses data reduction problems of unprecedented scale which are difficult to deal with traditional interactive tools. We present here NExt (Neural Extractor): a new Neural Network (NN) based package capable to detect objects and to perform both deblending and star/galaxy classification in an automatic way. Traditionally, in astronomical images, objects are first discriminated from the noisy background by searching for sets of connected pixels having brightnesses above a given threshold and then they are classified as stars or as galaxies through diagnostic diagrams having variables choosen accordingly to the astronomer's taste and experience. In the extraction step, assuming that images are well sampled, NExt requires only the simplest a priori definition of "what an object is" (id est, it keeps all structures composed by more than one pixels) and performs the detection via an unsupervised NN approaching detection as a clustering problem which has been thoroughly studied in the artificial intelligence literature. In order to obtain an objective and reliable classification, instead of using an arbitrarily defined set of features, we use a NN to select the most significant features among the large number of measured ones, and then we use their selected features to perform the classification task. In order to optimise the performances of the system we implemented and tested several different models of NN. The comparison of the NExt performances with those of the best detection and classification package known to the authors (SExtractor) shows that NExt is at least as effective as the best traditional packages., Comment: MNRAS, in press. Paper with higher resolution images is available at http://www.na.astro.it/~andreon/listapub.html

Published
2000
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11. Neural Nets and Star/Galaxy Separation in Wide Field Astronomical Images

Author

Andreon, S., Gargiulo, G., Longo, G., Tagliaferri, R., and Capuano, N.

Subjects
Astrophysics
Abstract

One of the most relevant problems in the extraction of scientifically useful information from wide field astronomical images (both photographic plates and CCD frames) is the recognition of the objects against a noisy background and their classification in unresolved (star-like) and resolved (galaxies) sources. In this paper we present a neural network based method capable to perform both tasks and discuss in detail the performance of object detection in a representative celestial field. The performance of our method is compared to that of other methodologies often used within the astronomical community., Comment: 6 pages, to appear in the proceedings of IJCNN 99, IEEE Press, 1999

Published
1999
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12. Sarcopenia: assessment of disease burden and strategies to improve outcomes

Author

Liguori I, Russo G, Aran L, Bulli G, Curcio F, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, and Abete P

Subjects
sarcopenia, elderly, assessment, therapy, Geriatrics, RC952-954.6
Abstract

Ilaria Liguori,1 Gennaro Russo,1 Luisa Aran,1 Giulia Bulli,1 Francesco Curcio,1 David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6 Domenico Bonaduce,1 Pasquale Abete1 1Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy; 2Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 3Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, Rome, Italy; 4Division of Internal Medicine, AOU San Giovanni di Dio e Ruggi di Aragona, Salerno, Italy; 5Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy; 6Azienda Ospedaliera dei Colli, Monaldi Hospital, Heart Transplantation Unit, Naples, Italy Abstract: Life expectancy is increasing worldwide, with a resultant increase in the elderly population. Aging is characterized by the progressive loss of skeletal muscle mass and strength – a phenomenon called sarcopenia. Sarcopenia has a complex multifactorial pathogenesis, which involves not only age-related changes in neuromuscular function, muscle protein turnover, and hormone levels and sensitivity, but also a chronic pro-inflammatory state, oxidative stress, and behavioral factors – in particular, nutritional status and degree of physical activity. According to the operational definition by the European Working Group on Sarcopenia in Older People (EWGSOP), the diagnosis of sarcopenia requires the presence of both low muscle mass and low muscle function, which can be defined by low muscle strength or low physical performance. Moreover, biomarkers of sarcopenia have been identified for its early detection and for a detailed identification of the main pathophysiological mechanisms involved in its development. Because sarcopenia is associated with important adverse health outcomes, such as frailty, hospitalization, and mortality, several therapeutic strategies have been identified that involve exercise training, nutritional supplementation, hormonal therapies, and novel strategies and are still under investigation. At the present time, only physical exercise has showed a positive effect in managing and preventing sarcopenia and its adverse health outcomes. Thus, further well-designed and well-conducted studies on sarcopenia are needed. Keywords: sarcopenia, elderly, assessment, therapy

Published
2018

13. Oxidative stress, aging, and diseases

Author

Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, and Abete P

Subjects
elderly, reactive oxygen species, reactive nitrogen species, antioxidants, Geriatrics, RC952-954.6
Abstract

Ilaria Liguori,1 Gennaro Russo,1 Francesco Curcio,1 Giulia Bulli,1 Luisa Aran,1 David Della-Morte,2,3 Gaetano Gargiulo,4 Gianluca Testa,1,5 Francesco Cacciatore,1,6 Domenico Bonaduce,1 Pasquale Abete1 1Department of Translational Medical Sciences, University of Naples “Federico II”, Naples, Italy; 2Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; 3San Raffaele Roma Open University, Rome, Italy; 4Division of Internal Medicine, AOU San Giovanni di Dio e Ruggi di Aragona, Salerno, Italy; 5Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy; 6Azienda Ospedaliera dei Colli, Monaldi Hospital, Heart Transplantation Unit, Naples, Italy Abstract: Reactive oxygen and nitrogen species (RONS) are produced by several endogenous and exogenous processes, and their negative effects are neutralized by antioxidant defenses. Oxidative stress occurs from the imbalance between RONS production and these antioxidant defenses. Aging is a process characterized by the progressive loss of tissue and organ function. The oxidative stress theory of aging is based on the hypothesis that age-associated functional losses are due to the accumulation of RONS-induced damages. At the same time, oxidative stress is involved in several age-related conditions (ie, cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancer), including sarcopenia and frailty. Different types of oxidative stress biomarkers have been identified and may provide important information about the efficacy of the treatment, guiding the selection of the most effective drugs/dose regimens for patients and, if particularly relevant from a pathophysiological point of view, acting on a specific therapeutic target. Given the important role of oxidative stress in the pathogenesis of many clinical conditions and aging, antioxidant therapy could positively affect the natural history of several diseases, but further investigation is needed to evaluate the real efficacy of these therapeutic interventions. The purpose of this paper is to provide a review of literature on this complex topic of ever increasing interest. Keywords: elderly, reactive oxygen species, reactive nitrogen species, antioxidants

Published
2018

15. Pharmacological modulators of epithelial immunity uncovered by synthetic genetic tracing of SARS-CoV-2 infection responses

Author

Jiang, B., Schmitt, M.J., Rand, U., Company, C., Dramaretska, Y., Grossmann, M., Serresi, M., Cicin-Sain, L., and Gargiulo, G.

Subjects
Cancer Research
Abstract

Epithelial immune responses govern tissue homeostasis and offer drug targets against maladaptation. Here, we report a framework to generate drug discovery–ready reporters of cellular responses to viral infection. We reverse-engineered epithelial cell responses to SARS-CoV-2, the viral agent fueling the ongoing COVID-19 pandemic, and designed synthetic transcriptional reporters whose molecular logic comprises interferon-α/β/γ and NF-κB pathways. Such regulatory potential reflected single-cell data from experimental models to severe COVID-19 patient epithelial cells infected by SARS-CoV-2. SARS-CoV-2, type I interferons, and RIG-I drive reporter activation. Live-cell image–based phenotypic drug screens identified JAK inhibitors and DNA damage inducers as antagonistic modulators of epithelial cell response to interferons, RIG-I stimulation, and SARS-CoV-2. Synergistic or antagonistic modulation of the reporter by drugs underscored their mechanism of action and convergence on endogenous transcriptional programs. Our study describes a tool for dissecting antiviral responses to infection and sterile cues and rapidly discovering rational drug combinations for emerging viruses of concern.

Published
2023

16. ‘Real-life’ report on the management of chronic GvHD in the Gruppo Italiano Trapianto Midollo Osseo (GITMO)

Author

Giaccone, L, Mancini, G, Mordini, N, Gargiulo, G, De Cecco, V, Angelini, S, Arpinati, M, Baronciani, D, Bozzoli, V, Bramanti, S, Calore, E, Cavattoni, I M, Cimminiello, M, Colombo, A A, Facchini, L, Falcioni, S, Faraci, M, Fedele, R, Guidi, S, Iori, A P, Marotta, S, Micò, M C, Milone, G, Onida, F, Pastore, D, Patriarca, F, Pini, M, Raimondi, R, Rovelli, A, Santarone, S, Severino, A, Skert, C, Stanghellini, M T L, Tecchio, C, Vassallo, E, Chiarucci, M, Bruno, B, Bonifazi, F, and Olivieri, A

Published
2018
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18. L’adesione alla vaccinazione antinfluenzale degli infermieri a contatto con pazienti immunocompressi

Author

D’Auria A., Lopes S., Panico C., Sansone V., Gargiulo G., Simeone S., and Rea T.

Subjects
vaccinazione antinfluenzale, infermieri, attitudini, comportamenti, adesione, Medicine, Nursing, RT1-120
Abstract

Introduzione: la vaccinazione antinfluenzale (VA) rappresenta uno degli interventi raccomandati per proteggere non solo operatori sanitari e pazienti ad alto rischio, ma la popolazione tutta. Lo scopo dello studio è stato valutare l’adesione alla VA da parte del personale infermieristico dedicato all’assistenza dei pazienti immunocompromessi presso l’A.O.U. “Federico II” di Napoli negli ultimi cinque anni. Ulteriori obiettivi sono stati: rilevare il fabbisogno formativo e comprendere i motivi della mancata adesione alla VA. Metodo: lo studio osservazionale è stato condotto da giugno a settembre 2015; è stato somministrato un questionario rivolto agli infermieri utilizzando un modulo di analisi on-line creato con la piattaforma G-Drive di Google. Risultati: sono stati somministrati un totale di 227 questionari con un tasso di adesione del 67.8%. Il 61.3% del campione creda nelle vaccinazioni quali strumenti importanti per la riduzione/eliminazione delle malattie. Nell’anno 2014-15, l’89% del campione non ha praticato la vaccinazione antinfluenzale. Negli ultimi 5 anni il 20.8% dichiara di essersi vaccinato soltanto una volta, l’11% due o più volte, mentre il 68.2% non si è mai vaccinato. Un ulteriore bisogno di informazioni è emerso nell’80% del campione. Conclusioni: l’assenza di un protocollo aziendale e le misconception sulla VA sembrano essere i principali elementi che hanno determinato i risultati. Vi è la necessità di attuare interventi capaci di stimolare gli operatori a comprendere l’importanza della VA, sviluppando una maggiore l’adesione.

Published
2016
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22. Impact of alirocumab added to high-intensity statin therapy on platelet function in AMI patients: a pre-specified substudy of the randomized, placebo-controlled PACMAN-AMI trial

Author

Ueki, Y, primary, Haner, J, additional, Losdat, S, additional, Gargiulo, G, additional, Bar, S, additional, Otsuka, T, additional, Kavaliauskaite, R, additional, Mitter, V, additional, Temperli, F, additional, Shibutani, H, additional, Siontis, G, additional, Valgimigli, M, additional, Windecker, S, additional, Koskinas, K, additional, and Raber, L, additional

Published
2022
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27. Pointwise and Uniform Power Series Convergence

Author

D’Apice, C., Gargiulo, G., Manzo, R., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Sunderam, Vaidy S., editor, van Albada, Geert Dick, editor, Sloot, Peter M. A., editor, and Dongarra, Jack, editor

Published
2005
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28. Ticagrelor Monotherapy or Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation: Per-Protocol Analysis of the GLOBAL LEADERS Trial

Author

Gragnano, F., Zwahlen, M., Vranckx, P., Heg, D., Schmidlin, K., Hamm, C., Steg, P.G., Gargiulo, G., McFadden, E.P., Onuma, Y., Chichareon, P., Benit, E., Möllmann, H., Janssens, L., Leonardi, S., Zurakowski, A., Arrivi, A., Geuns, R.J.M. van, Huber, K., Slagboom, T., Calabrò, P., Serruys, P.W., Jüni, P., Valgimigli, M., Windecker, S., Gragnano, F., Zwahlen, M., Vranckx, P., Heg, D., Schmidlin, K., Hamm, C., Steg, P.G., Gargiulo, G., McFadden, E.P., Onuma, Y., Chichareon, P., Benit, E., Möllmann, H., Janssens, L., Leonardi, S., Zurakowski, A., Arrivi, A., Geuns, R.J.M. van, Huber, K., Slagboom, T., Calabrò, P., Serruys, P.W., Jüni, P., Valgimigli, M., and Windecker, S.

Abstract

Contains fulltext : 252201.pdf (Publisher’s version ) (Open Access), Background In the GLOBAL LEADERS trial, ticagrelor monotherapy beyond 1 month compared with standard antiplatelet regimens after coronary stent implantation did not improve outcomes at intention-to-treat analysis. Considerable differences in treatment adherence between the experimental and control groups may have affected the intention-to-treat results. In this reanalysis of the GLOBAL LEADERS trial, we compared the experimental and control treatment strategies in a per-protocol analysis of patients who did not deviate from the study protocol. Methods and Results Baseline and postrandomization information were used to classify whether and when patients were deviating from the study protocol. With logistic regressions, we derived time-varying inverse probabilities of nondeviation from protocol to reconstruct the trial population without protocol deviation. The primary end point was a composite of all-cause mortality or nonfatal Q-wave myocardial infarction at 2 years. At 2-year follow-up, 1103 (13.8%) of 7980 patients in the experimental group and 785 (9.8%) of 7988 patients in the control group qualified as protocol deviators. At per-protocol analysis, the rate ratio for the primary end point was 0.88 (95% CI, 0.75-1.03; P=0.10) on the basis of 274 versus 325 events in the experimental versus control group. The rate ratio for the key safety end point of major bleeding was 1.00 (95% CI, 0.79-1.26; P=0.99). The per-protocol and intention-to-treat effect estimates were overall consistent. Conclusions Among patients who complied with the study protocol in the GLOBAL LEADERS trial, ticagrelor plus aspirin for 1 month followed by ticagrelor monotherapy was not superior to 1-year standard dual antiplatelet therapy followed by aspirin alone at 2 years after coronary stenting. Registration URL: https://www.clinicaltrials.gov; Unique identifier: NCT01813435.

Published
2022

29. Prevention of Surgical Site Infections in Neonates and Children: Non-Pharmacological Measures of Prevention

Author

Meoli, A., Ciavola, L., Rahman, S., Masetti, M., Toschetti, T., Morini, R., Dal Canto, G., Auriti, C., Caminiti, C., Castagnola, E., Conti, Giorgio, Dona, D., Galli, Lavinia Maddalena, La Grutta, S., Lancella, L., Lima, M., Lo Vecchio, A., Pelizzo, G., Petrosillo, Nicola, Simonini, A., Venturini, Elena, Caramelli, F., Gargiulo, G. D., Sesenna, E., Sgarzani, R., Vicini, Cinzia, Zucchelli, M., Mosca, F., Staiano, A., Principi, N., Esposito, S., Conti G. (ORCID:0000-0002-8566-9365), Galli L., Petrosillo N., Venturini E., Vicini C., Meoli, A., Ciavola, L., Rahman, S., Masetti, M., Toschetti, T., Morini, R., Dal Canto, G., Auriti, C., Caminiti, C., Castagnola, E., Conti, Giorgio, Dona, D., Galli, Lavinia Maddalena, La Grutta, S., Lancella, L., Lima, M., Lo Vecchio, A., Pelizzo, G., Petrosillo, Nicola, Simonini, A., Venturini, Elena, Caramelli, F., Gargiulo, G. D., Sesenna, E., Sgarzani, R., Vicini, Cinzia, Zucchelli, M., Mosca, F., Staiano, A., Principi, N., Esposito, S., Conti G. (ORCID:0000-0002-8566-9365), Galli L., Petrosillo N., Venturini E., and Vicini C.

Abstract

A surgical site infection (SSI) is an infection that occurs in the incision created by an invasive surgical procedure. Although most infections are treatable with antibiotics, SSIs remain a significant cause of morbidity and mortality after surgery and have a significant economic impact on health systems. Preventive measures are essential to decrease the incidence of SSIs and antibiotic abuse, but data in the literature regarding risk factors for SSIs in the pediatric age group are scarce, and current guidelines for the prevention of the risk of developing SSIs are mainly focused on the adult population. This document describes the current knowledge on risk factors for SSIs in neonates and children undergoing surgery and has the purpose of providing guidance to health care professionals for the prevention of SSIs in this population. Our aim is to consider the possible non-pharmacological measures that can be adopted to prevent SSIs. To our knowledge, this is the first study to provide recommendations based on a careful review of the available scientific evidence for the non-pharmacological prevention of SSIs in neonates and children. The specific scenarios developed are intended to guide the healthcare professional in practice to ensure standardized management of the neonatal and pediatric patients, decrease the incidence of SSIs and reduce antibiotic abuse.

Published
2022

30. Age-related reduction of cerebral ischemic preconditioning: myth or reality?

Author

Della-Morte D, Caciatore F, Salsano E, Pirozzi G, Del Genio MT, D'Antonio I, Gargiulo G, Palmirotta R, Guadagni F, Rundek T, and Abete P

Subjects
ischemic preconditioning, stroke, transitory cerebral ischemic attack, mortality, elderly, Geriatrics, RC952-954.6
Abstract

David Della-Morte,1,2 Francesco Cacciatore,3 Elisa Salsano,4 Gilda Pirozzi,4 Maria Teresa Del Genio,4 Iole D'Antonio,4 Gaetano Gargiulo,5 Raffaele Palmirotta,2 Fiorella Guadagni,2 Tatjana Rundek,1 Pasquale Abete41Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA; 2Department of Advanced Biotechnologies and Bioimaging, IRCCS San Raffaele, Rome, Italy; 3Istituto Scientifico di Campoli/Telese, Fondazione Salvatore Maugeri, IRCCS, Benevento, Italy; 4Dipartimento di Scienze Mediche Traslazionali, Università di Napoli "Federico II," Naples, Italy; 5AON, SS Antonio e Biagio e Cesare Arrigo, Struttura Complessa di Geriatria, Alessandria, ItalyAbstract: Stroke is one of the leading causes of death in industrialized countries for people older than 65 years of age. The reasons are still unclear. A reduction of endogenous mechanisms against ischemic insults has been proposed to explain this phenomenon. The “cerebral” ischemic preconditioning mechanism is characterized by a brief episode of ischemia that renders the brain more resistant against subsequent longer ischemic events. This ischemic tolerance has been shown in numerous experimental models of cerebral ischemia. This protective mechanism seems to be reduced with aging both in experimental and clinical studies. Alterations of mediators released and/or intracellular pathways may be responsible for age-related ischemic preconditioning reduction. Agents able to mimic the “cerebral” preconditioning effect may represent a new powerful tool for the treatment of acute ischemic stroke in the elderly. In this article, animal and human cerebral ischemic preconditioning, its age-related difference, and its potential therapeutical applications are discussed.Keywords: ischemic preconditioning, stroke, transient cerebral ischemic attack, mortality, elderly

Published
2013

32. Influenza vaccination and healthcare workers: barriers and predisposing factors

Author

Guillari A, Polito F, Pucciarelli G, Serra N, Gargiulo G, Esposito MR, Botti S, Rea T, SIMEONE S, Guillari, A, Polito, F, Pucciarelli, G, Serra, N, Gargiulo, G, Esposito, Mr, Botti, S, Rea, T, and Simeone, S

Abstract

Background and aim of the work: Influenza is a disease that affects a large part of the world's population annually, with major health, social and economic impacts. Active immunisation practices have always been recommended to counter influenza, especially for people at risk. The recommendations of major health agencies strongly advise influenza vaccination for all healthcare workers, mostly for those in contact with at-risk or immunocompromised individuals. Yet, the influenza vaccination coverage among healthcare workers remains rather low worldwide. This review explore barriers and the facilitators of health care professional toward influenza's vaccination. Methods: Narrative review consulting the databases: PubMed, CINAHL by combining keywords health care worker, flu, influenza, vaccination, barrier, resistence, hesitangy, between November 2019 and February 2020 Results. From the 1031 records initially, twenty-two primary studies were included in this narrative review. Our results show that the identified facilitators are: desire for self-protection, protection for loved ones and community. Instead, the barriers to vaccination identified are: fear of contracting influenza from the vaccination itself; not considering themselves at risk; to believing believe that their immune system is capable of managing a trivial disease; disease considered trivial, laziness; false beliefs. Discussion and conclusion: Adherence rate on influenza vaccination among health professionals is quite low. The interventions that make it "complex and traceable" flu vaccination refusal increase adherence to this type of vaccination. The results show that current vaccination campaigns do not increase the rate of adherence by healthcare workers. Identifying the predisposing factors and barriers to such vaccination can help to create, develop and test targeted educational programmes.

Published
2021

33. Multi-omics and deep learning provide a multifaceted view of cancer

Author

Altuna Akalin, Franke, Gargiulo G, Jonathan Ronen, and Bora Uyar

Subjects
Transcriptome, Computer science, business.industry, Deep learning, Proteome, Metabolome, Microbiome, Epigenome, Artificial intelligence, Disease, Computational biology, business, Genome
Abstract

Cancer is a complex disease with a large financial and healthcare burden on society. One hallmark of the disease is the uncontrolled growth and proliferation of malignant cells. Unlike Mendelian diseases which may be explained by a few genomic loci, a deeper molecular and mechanistic understanding of the development of cancer is needed. Such an endeavor requires the integration of tens of thousands of molecular features across multiple layers of information encoded in the cells. In practical terms, this implies integration of multi omics information from the genome, transcriptome, epigenome, proteome, metabolome, and even micro-environmental factors such as the microbiome. Finding mechanistic insights and biomarkers in such a high dimensional space is a challenging task. Therefore, efficient machine learning techniques are needed to reduce the dimensionality of the data while simultaneously discovering complex but meaningful biomarkers. These markers then can lead to testable hypotheses in research and clinical applications. In this study, we applied advanced deep learning methods to uncover multi-omic fingerprints that are associated with a wide range of clinical and molecular features of tumor samples. Using these fingerprints, we can accurately classify different cancer types, and their subtypes. Non-linear multi-omic fingerprints can uncover clinical features associated with patient survival and response to treatment, ranging from chemotherapy to immunotherapy. In addition, multi-omic fingerprints may be deconvoluted into a meaningful subset of genes and genomic alterations to support clinically relevant decisions.Graphical Abstract

Published
2021

37. Uniportal and three-portal video-assisted thoracic surgery lobectomy: analysis of the Italian video-assisted thoracic surgery group database

Author

Tosi, D, Nosotti, M, Bonitta, G, Mazzucco, A, Righi, I, Mendogni, P, Rosso, L, Palleschi, A, Rocco, G, Crisci, R, Mancuso, M, Pernazza, F, Refai, M, Bortolotti, L, Rizzardi, G, Gargiulo, G, Dolci, Gp, Perkmann, R, Zaraca, F, Benvenuti, M, Gavezzoli, D, Cherchi, R, Ferrari, P, Mucilli, F, Camplese, P, Melloni, G, Mazza, F, Cavallesco, G, Maniscalco, P, Voltolini, L, Gonfiotti, A, Stella, F, Argnani, D, Pariscenti, Gl, Lurilli, Surrente, C, Lopez, C, Droghetti, A, Giovanardi, M, Breda, C, Lo Giudice, F, Alloisio, M, Bottoni, E, Spaggiari, L, Gasparri, R, Torre, M, Rinaldo, A, Negri, Gp, Bandiera, A, Stefani, A, Natali, P, Scarci, M, Pirondini, E, Curcio, C, Amore, D, Baietto, G, Casadio, C, Nicotra, S, Dell'Amore, A, Bertani, A, Russo, E, Ampollini, L, Carbognani, P, Puma, F, Vinci, D, Andreetti, C, Poggi, C, Cardillo, G, Margaritora, S, Meacci, Elisa, Luzzi, L, Ghisalberti, M, Zaccagna, G, Lausi, P, Guerrera, F, Fontana, D, Della Beffa, V, Morelli, A, Londero, F, Imperatori, A, Rotolo, N, Terzi, A, Viti, A, Infante, M, Benato, C, Tosi, D., Nosotti, M., Bonitta, G., Mazzucco, A., Righi, I., Mendogni, P., Rosso, L., Palleschi, A., Rocco, G., Crisci, R., Mancuso, M., Pernazza, F., Refai, M., Bortolotti, L., Rizzardi, G., Gargiulo, G., Dolci, G. P., Perkmann, R., Zaraca, F., Benvenuti, M., Gavezzoli, D., Cherchi, R., Ferrari, P., Mucilli, F., Camplese, P., Melloni, G., Mazza, F., Cavallesco, G., Maniscalco, P., Voltolini, L., Gonfiotti, A., Stella, F., Argnani, D., Pariscenti, G. L., Surrente, C., Lopez, C., Droghetti, A., Giovanardi, M., Breda, C., Lo Giudice, F., Alloisio, M., Bottoni, E., Spaggiari, L., Gasparri, R., Torre, M., Rinaldo, A., Negri, G, Bandiera, A., Stefani, A., Natali, P., Scarci, M., Pirondini, E., Curcio, C., Amore, D., Baietto, G., Casadio, C., Nicotra, S., Dell'Amore, A., Bertani, A., Russo, E., Ampollini, L., Carbognani, P., Puma, F., Vinci, D., Andreetti, C., Poggi, C., Cardillo, G., Margaritora, S., Meacci, E., Luzzi, L., Ghisalberti, M., Zaccagna, G., Lausi, P., Guerrera, F., Fontana, D., Della Beffa, V., Morelli, A., Londero, F., Imperatori, A., Rotolo, N., Terzi, A., Viti, A., Infante, M., Benato, C., Tosi D., Nosotti M., Bonitta G., Mazzucco A., Righi I., Mendogni P., Rosso L., Palleschi A., Rocco G., Crisci R., Mancuso M., Pernazza F., Refai M., Bortolotti L., Rizzardi G., Gargiulo G., Dolci G.P., Perkmann R., Zaraca F., Benvenuti M., Gavezzoli D., Cherchi R., Ferrari P., Mucilli F., Camplese P., Melloni G., Mazza F., Cavallesco G., Maniscalco P., Voltolini L., Gonfiotti A., Stella F., Argnani D., Pariscenti G.L., Surrente C., Lopez C., Droghetti A., Giovanardi M., Breda C., Lo Giudice F., Alloisio M., Bottoni E., Spaggiari L., Gasparri R., Torre M., Rinaldo A., Negri G.P., Bandiera A., Stefani A., Natali P., Scarci M., Pirondini E., Curcio C., Amore D., Baietto G., Casadio C., Nicotra S., Dell'amore A., Bertani A., Russo E., Ampollini L., Carbognani P., Puma F., Vinci D., Andreetti C., Poggi C., Cardillo G., Margaritora S., Meacci E., Luzzi L., Ghisalberti M., Zaccagna G., Lausi P., Guerrera F., Fontana D., Della Beffa V., Morelli A., Londero F., Imperatori A., Rotolo N., Terzi A., Viti A., Infante M., and Benato C.

Subjects
Male, Lung Neoplasms, Thoracic, Italian VATS Group, computer.software_genre, Postoperative pain, Settore MED/21 - CHIRURGIA TORACICA, Carcinoma, Non-Small-Cell Lung, Lobectomy, Three-portal, Uniportal, Video-assisted thoracic surgery, Aged, Equipment Design, Female, Humans, Neoplasm Staging, Operative Time, Pneumonectomy, Retrospective Studies, Thoracic Surgery, Video-Assisted, Tomography, X-Ray Computed, Stage (cooking), Non-Small-Cell Lung, Tomography, Database, Thoracic Surgery, X-Ray Computed, Cardiothoracic surgery, Cohort, Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, Italian VATS Group, Lobectomy, Postoperative pain, Three-portal, Uniportal, Video-assisted thoracic surgery, medicine.medical_specialty, VATS lobectomy, Video-Assisted, NO, medicine, Lung cancer, business.industry, Carcinoma, Odds ratio, medicine.disease, Confidence interval, Propensity score matching, Surgery, business, computer
Abstract

OBJECTIVES This study compares the uniportal with the 3-portal video-assisted thoracic surgery (VATS) by examining the data collected in the Italian VATS Group Database. The primary end point was early postoperative pain; secondary end points were intraoperative and postoperative complications, surgical time, number of dissected lymph nodes and length of stay. METHODS This was an observational, retrospective, cohort, multicentre study on data collected by 49 Italian thoracic units. Inclusion criteria were clinical stage I–II non-small-cell lung cancer, uniportal or 3-portal VATS lobectomy and R0 resection. Exclusion criteria were cT3 disease, previous thoracic malignancy, induction therapy, significant comorbidities and conversion to other techniques. The pain parameter was dichotomized: the numeric rating scale ≤3 described mild pain, whereas the numeric rating scale score >3 described moderate/severe pain. The propensity score-adjusted generalized estimating equation was used to compare the uniportal with 3-portal lobectomy. RESULTS Among 4338 patients enrolled from January 2014 to July 2017, 1980 met the inclusion criteria; 1808 patients underwent 3-portal lobectomy and 172 uniportal surgery. The adjusted generalized estimating equation regression model using the propensity score showed that over time pain decreased in both groups (P CONCLUSIONS Data from the Italian VATS Group Database showed that in clinical practice uniportal lobectomy seems to entail a higher risk of moderate/severe pain on second and third postoperative days.

Published
2019

40. Wearable Bluetooth Triage Healthcare Monitoring System.

Author

Polley, C, Jayarathna, T, Gunawardana, U, Naik, G, Hamilton, T, Andreozzi, E, Bifulco, P, Esposito, D, Centracchio, J, Gargiulo, G, Polley, C, Jayarathna, T, Gunawardana, U, Naik, G, Hamilton, T, Andreozzi, E, Bifulco, P, Esposito, D, Centracchio, J, and Gargiulo, G

Abstract

Triage is the first interaction between a patient and a nurse/paramedic. This assessment, usually performed at Emergency departments, is a highly dynamic process and there are international grading systems that according to the patient condition initiate the patient journey. Triage requires an initial rapid assessment followed by routine checks of the patients' vitals, including respiratory rate, temperature, and pulse rate. Ideally, these checks should be performed continuously and remotely to reduce the workload on triage nurses; optimizing tools and monitoring systems can be introduced and include a wearable patient monitoring system that is not at the expense of the patient's comfort and can be remotely monitored through wireless connectivity. In this study, we assessed the suitability of a small ceramic piezoelectric disk submerged in a skin-safe silicone dome that enhances contact with skin, to detect wirelessly both respiration and cardiac events at several positions on the human body. For the purposes of this evaluation, we fitted the sensor with a respiratory belt as well as a single lead ECG, all acquired simultaneously. To complete Triage parameter collection, we also included a medical-grade contact thermometer. Performances of cardiac and respiratory events detection were assessed. The instantaneous heart and respiratory rates provided by the proposed sensor, the ECG and the respiratory belt were compared via statistical analyses. In all considered sensor positions, very high performances were achieved for the detection of both cardiac and respiratory events, except for the wrist, which provided lower performances for respiratory rates. These promising yet preliminary results suggest the proposed wireless sensor could be used as a wearable, hands-free monitoring device for triage assessment within emergency departments. Further tests are foreseen to assess sensor performances in real operating environments.

Published
2021

41. A Silicon Neuron-based Bio-Front-End for Ultra Low Power Bio-Monitoring at the Edge

Author

Shivangi, TP, Rahimi, M, Gargiulo, G, Kailath, BJ, Hamilton, TJ, Shivangi, TP, Rahimi, M, Gargiulo, G, Kailath, BJ, and Hamilton, TJ

Abstract

This paper presents the circuits for an edge-based bio-front-end implemented using an integrate-and-fire silicon neuron model in 22nm SOI CMOS Technology. The proposed implementation encodes both positive and negative input signals separately and, like its biological counterpart, provides asynchronous output. This asynchronous output allows for maximum sensitivity to high-information content input signals and low sensitivity for low-information content. In the proposed design, the firing rate can be controlled by an adaptation circuit to achieve maximum power savings. We demonstrate this design with a sinusoidal test signal and pre-recorded ECG signals. The proposed design achieves ultra-low-power consumption; by applying a sinusoidal input and ECG input the power consumption without adaptation (with adaptation) is 4. 069SnW(3.999nW) and 5. 1529nW (3.311SnW), respectively. In addition, the reconstruction of the ECG signal is demonstrated and the signal to error for the reconstructed ECG signal is 30.2 dB.

Published
2021

42. USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells

Author

van den Berk, P., Lancini, C., Company, C., Serresi, M., Sanchez-Bailon, M.P., Hulsman, D., Pritchard, C., Song, J.Y., Schmitt, M.J., Tanger, E., Popp, O., Mertins, P., Huijbers, I.J., Jacobs, H., van Lohuizen, M., Gargiulo, G., and Citterio, E.

Subjects
Cancer Research, DNA Repair, HSC, DNA damage response, Article, Cell Line, fused in sarcoma, Mice, Animals, Humans, RNA, Small Interfering, FUS, Cell Proliferation, in vivo shRNA screen, Mice, Knockout, Leukemia, Deubiquitinating Enzymes, Ubiquitination, Hematopoietic Stem Cells, USP15, Hematopoiesis, Mice, Inbred C57BL, deubiquitinase, genome integrity, RNAi, Models, Animal, RNA-Binding Protein FUS, hematopoietic stem cell, RNA Interference, Ubiquitin-Specific Proteases, Technology Platforms, K562 Cells, DNA Damage
Abstract

Summary Altering ubiquitination by disruption of deubiquitinating enzymes (DUBs) affects hematopoietic stem cell (HSC) maintenance. However, comprehensive knowledge of DUB function during hematopoiesis in vivo is lacking. Here, we systematically inactivate DUBs in mouse hematopoietic progenitors using in vivo small hairpin RNA (shRNA) screens. We find that multiple DUBs may be individually required for hematopoiesis and identify ubiquitin-specific protease 15 (USP15) as essential for HSC maintenance in vitro and in transplantations and Usp15 knockout (KO) mice in vivo. USP15 is highly expressed in human hematopoietic tissues and leukemias. USP15 depletion in murine progenitors and leukemia cells impairs in vitro expansion and increases genotoxic stress. In leukemia cells, USP15 interacts with and stabilizes FUS (fused in sarcoma), a known DNA repair factor, directly linking USP15 to the DNA damage response (DDR). Our study underscores the importance of DUBs in preserving normal hematopoiesis and uncovers USP15 as a critical DUB in safeguarding genome integrity in HSCs and leukemia cells., Graphical Abstract, Highlights • In vivo shRNAs screens for deubiquitinases identify regulators of murine hematopoiesis • Usp15 deletion compromises HSC maintenance and reconstitution potential in vivo • USP15 loss affects genome integrity and growth of mHSPCs and human leukemia cells • In human leukemia cells, USP15 stabilizes its interactor, FUS, a DNA repair factor, Van den Berk et al. use unbiased in vivo RNAi screens targeting deubiquitinases in mouse hematopoietic stem and progenitor cells. This study underscores the importance of deubiquitinases in hematopoietic stem cell function and reveals the role of USP15 in preserving genome integrity in normal and transformed hematopoietic cells.

Published
2020

44. The natural history and surgical outcome of patients with scimitar syndrome: a multi-centre European study

Author

Vida, Vladimiro L, Guariento, Alvise, Milanesi, Ornella, Gregori, Dario, Stellin, Giovanni, Zucchetta F, Zanotto L, Padalino MA, Castaldi B, Bosiznik S, Crepaz R, Stuefer J, de Maria Garcia Gonzales F, Castaneda AR, Crupi G, Agnoletti G, Bondanza S, Marasini M, Zannini L, Butera G, Frigiola A, Varrica A, Chiappa E, Pilati M, Carotti A, Matteo T, Prandstraller D, Gargiulo G, Giovanna Russo M, Santoro G, Caianiello G, Spadoni I, Murzi B, Arcieri L, Pozzi M, Porcedda G, Berggren H, Carrel T, Kadner A, Çiçek S, Zorman Y, Fragata J, Gordo A, Hazekamp M, Sojak V, Hraska V, Asfour B, Maruszewski B, Kozlowski M, Metras D, Pretre R, Rubay J, Sairanen H, Sarris G, Schreiber C, Ono M, Meyns B, Van den Bossche K, Tlaskal T, Lo Rito M, Joon Yoo S, Van Arsdell GS, Calderone C, Iwamoto Y, Leon-Wyss J, Di Filippo S, Leconte C, Mulder BJ, Ebels T, Arrigoni S, Valsangiacomo E, Hitendu D, Konstantinov IE, Gamillscheg A, Gabriela D, Herberg U, Dulac Y, Edmerger J, Zarate Fuentes A, Miguel Gil Jaurena J, Bo I, Ghez O, Rigby ML, Bacha EA, Kalfa D, Speggiorin S, Bu'Lock F, Al-Ahmadi M, Di Salvo G, Surmacz R, Yemets IM, Mykychak YB, Lugones I, Cameron DE, Vricella LA, Troconis CJ, Thiene G, Angelini A, Zanotto L., Vida, Vladimiro L, Guariento, Alvise, Milanesi, Ornella, Gregori, Dario, Stellin, Giovanni, Zucchetta F, Zanotto L, Padalino MA, Castaldi B, Bosiznik S, Crepaz R, Stuefer J, de Maria Garcia Gonzales F, Castaneda AR, Crupi G, Agnoletti G, Bondanza S, Marasini M, Zannini L, Butera G, Frigiola A, Varrica A, Chiappa E, Pilati M, Carotti A, Matteo T, Prandstraller D, Gargiulo G, Giovanna Russo M, Santoro G, Caianiello G, Spadoni I, Murzi B, Arcieri L, Pozzi M, Porcedda G, Berggren H, Carrel T, Kadner A, Çiçek S, Zorman Y, Fragata J, Gordo A, Hazekamp M, Sojak V, Hraska V, Asfour B, Maruszewski B, Kozlowski M, Metras D, Pretre R, Rubay J, Sairanen H, Sarris G, Schreiber C, Ono M, Meyns B, Van den Bossche K, Tlaskal T, Lo Rito M, Joon Yoo S, Van Arsdell GS, Calderone C, Iwamoto Y, Leon-Wyss J, Di Filippo S, Leconte C, Mulder BJ, Ebels T, Arrigoni S, Valsangiacomo E, Hitendu D, Konstantinov IE, Gamillscheg A, Gabriela D, Herberg U, Dulac Y, Edmerger J, Zarate Fuentes A, Miguel Gil Jaurena J, Bo I, Ghez O, Rigby ML, Bacha EA, Kalfa D, Speggiorin S, Bu'Lock F, Al-Ahmadi M, Di Salvo G, Surmacz R, Yemets IM, Mykychak YB, Lugones I, Cameron DE, Vricella LA, Troconis CJ, Thiene G, Angelini A, Zanotto L., Cardiology, APH - Personalized Medicine, APH - Aging & Later Life, ACS - Heart failure & arrhythmias, Cardiothoracic Surgery, Zucchetta, F, Zanotto, L, Padalino, Ma, Castaldi, B, Bosiznik, S, Crepaz, R, Stuefer, J, De Maria Garcia Gonzales, F, Castaneda, Ar, Crupi, G, Agnoletti, G, Bondanza, S, Marasini, M, Zannini, LUIGI PIERO, Butera, G, Frigiola, A, Varrica, A, Chiappa, E, Pilati, M, Carotti, A, Matteo, T, Prandstraller, D, Gargiulo, G, Giovanna Russo, M, Santoro, G, Caianiello, G, Spadoni, I, Murzi, B, Arcieri, L, Pozzi, M, Porcedda, G, Berggren, H, Carrel, T, Kadner, A, Çiçek, S, Zorman, Y, Fragata, J, Gordo, A, Hazekamp, M, Sojak, V, Hraska, V, Asfour, B, Maruszewski, B, Kozlowski, M, Metras, D, Pretre, R, Rubay, J, Sairanen, H, Sarris, G, Schreiber, C, Ono, M, Meyns, B, Van Den Bossche, K, Tlaskal, T, Lo Rito, M, Joon Yoo, S, Van Arsdell, G, Calderone, C, Iwamoto, Y, Leon-wyss, J, Di Filippo, S, Leconte, C, Mulder, Bj, Ebels, T, Arrigoni, S, Valsangiacomo, E, Hitendu, D, Konstantinov, Ie, Gamillscheg, A, Gabriela, D, Herberg, U, Dulac, Y, Edmerger, J, Zarate Fuentes, A, Miguel Gil Jaurena, J, Bo, I, Ghez, O, Rigby, Ml, Bacha, Ea, Kalfa, D, Speggiorin, S, Bu'Lock, F, Al-ahmadi, M, Di Salvo, G, Surmacz, R, Yemets, Im, Mykychak, Yb, Lugones, I, Cameron, De, Vricella, La, Troconis, Cj, Thiene, G, Angelini, A, Zanotto, L., and University of Zurich

Subjects
Male, Pediatrics, medicine.medical_specialty, Time Factors, Natural history, 610 Medicine & health, Congenital heart defect, Multi-centre study, Surgery, 030204 cardiovascular system & hematology, Asymptomatic, 2705 Cardiology and Cardiovascular Medicine, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Scimitar syndrome, medicine, Humans, Registries, Cardiac Surgical Procedures, Retrospective Studies, business.industry, Incidence (epidemiology), Incidence, Scimitar Syndrome, Infant, Newborn, Infant, Retrospective cohort study, Odds ratio, medicine.disease, Pulmonary hypertension, Echocardiography, Doppler, Europe, Survival Rate, Stenosis, Treatment Outcome, 030228 respiratory system, 10036 Medical Clinic, Pulmonary Veins, Child, Preschool, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract

Aims Treatment decisions in patients with scimitar syndrome (SS) are often challenging, especially in patients with isolated SS who are often asymptomatic and who might be diagnosed accidentally. We queried a large multi-institutional registry of SS patients to evaluate the natural history of this condition and to determine the efficacy of surgical treatment in terms of survival and clinical status. Methods and results We collected data on 485 SS patients from 51 institutions; 279 (57%) patients were treated surgically (STPs) and 206 (43%) were clinically monitored (CMPs). Median age at last follow-up was 11.6 years (interquartile range 4-22 years). Overall survival probability at 30 years of age was 88% [85-92% confidence intervals (CI)] and was lower in patients with associated congenital heart disease (CHD) (P

Published
2018

46. What counts more: The patient, the surgical technique, or the hospital? A multivariable analysis of factors affecting perioperative complications of pulmonary lobectomy by video-assisted thoracoscopic surgery from a large nationwide registry

Author

Infante, Maurizio V, Benato, Cristiano, Silva, Ronaldo, Rocco, Gaetano, Bertani, Alessandro, Bertolaccini, Luca, Gonfiotti, Alessandro, Giovannetti, Riccardo, Bonadiman, Cinzia, Lonardoni, Alessandro, Canneto, Barbara, Falezza, Giovanni, Gandini, Paola, Curcio, Carlo, Crisci, Roberto, Alloisio, M, Amore, D, Ampollini, L, Andreetti, C, Argnani, D, Baietto, G, Bandiera, A, Benato, C, Benvenuti, M, Bertani, A, Bertolaccini, L, Bortolotti, L, Bottoni, E, Breda, C, Camplese, P, Carbognani, P, Cardillo, G, Casadio, C, Cavallesco, G, Cherchi, R, Crisci, R, Curcio, C, Dell'Amore, A, Beffa, V, Dolci, G, Droghetti, A, Ferrari, Pa, Fontana, D, Gargiulo, G, Gasparri, R, Gavezzoli, D, Ghisalberti, M, Giovanardi, M, Gonfiotti, A, Guerrera, F, Imperatori, A, Infante, M, Iurilli, L, Lausi, P, Logiudice, F, Londero, F, Lopez, C, Luzzi, L, Mancuso, M, Maniscalco, P, Margaritora, S, Meacci, E, Melloni, G, Morelli, A, Mucilli, F, Natali, P, Negri, G, Nicotra, S, Nosotti, M, Pariscenti, G, Perkmann, R, Pernazza, F, Pirondini, E, Poggi, C, Puma, F, Refai, M, Rinaldo, A, Rizzardi, G, Rosso, L, Rotolo, N, Russo, E, Sabbatini, A, Scarci, M, Spaggiari, L, Stefani, A, Solli, P, Surrente, C, Terzi, A, Torre, M, Vinci, D, Viti, A, Voltolini, L, Zaccagna, G, Zaraca, F., Infante M.V., Benato C., Silva R., Rocco G., Bertani A., Bertolaccini L., Gonfiotti A., Giovannetti R., Bonadiman C., Lonardoni A., Canneto B., Falezza G., Gandini P., Curcio C., Crisci R., Zaraca F., Alloisio M., Amore D., Ampollini L., Andreetti C., Argnani D., Baietto G., Bandiera A., Benvenuti M., Bortolotti L., Bottoni E., Breda C., Camplese P., Carbognani P., Cardillo G., Casadio C., Cavallesco G., Cherchi R., Dell'Amore A., Beffa V., Dolci G., Droghetti A., Ferrari P.A., Fontana D., Gargiulo G., Gasparri R., Gavezzoli D., Ghisalberti M., Giovanardi M., Guerrera F., Imperatori A., Iurilli L., Lausi P., Lo Giudice F., Londero F., Lopez C., Luzzi L., Mancuso M., Maniscalco P., Margaritora S., Meacci E., Melloni G., Morelli A., Mucilli F., Natali P., Negri G., Nicotra S., Nosotti M., Pariscenti G., Perkmann R., Pernazza F., Pirondini E., Poggi C., Puma F., Refai M., Rinaldo A., Rizzardi G., Rosso L., Rotolo N., Russo E., Sabbatini A., Scarci M., Spaggiari L., Stefani A., Solli P., Surrente C., Terzi A., Torre M., Vinci D., Viti A., Voltolini L., Zaccagna G., Infante, M. V., Benato, C., Silva, R., Rocco, G., Bertani, A., Bertolaccini, L., Gonfiotti, A., Giovannetti, R., Bonadiman, C., Lonardoni, A., Canneto, B., Falezza, G., Gandini, P., Curcio, C., Crisci, R., the Italian VATS group, Member, and Negri, G.

Subjects
Male, Registrie, Conversion, Morbidity, Postoperative complications, Video-assisted thoracoscopic surgery lobectomy, Lung Neoplasms, Intraoperative Complication, Aged, Female, Hospitals, Humans, Intraoperative Complications, Lung, Middle Aged, Pneumonectomy, Postoperative Complications, Registries, Retrospective Studies, Risk Factors, Thoracic Surgery, Video-Assisted, medicine.medical_treatment, Interquartile range, Retrospective Studie, Settore MED/21 - CHIRURGIA TORACICA, Conversion, Morbidity, Postoperative complications, Video-assisted thoracoscopic surgery lobectomy, Thoracic Surgery, General Medicine, Video-assisted thoracoscopic surgery, Cardiology and Cardiovascular Medicine, Human, Pulmonary and Respiratory Medicine, medicine.medical_specialty, VATS lobectomy, Video-Assisted, NO, Hospital, medicine, business.industry, Risk Factor, Retrospective cohort study, Perioperative, medicine.disease, Comorbidity, Surgery, Postoperative complication, Lung Neoplasm, Complication, business
Abstract

OBJECTIVESInherent technical aspects of pulmonary lobectomy by video-assisted thoracoscopic surgery (VATS) may limit surgeons’ ability to deal with factors predisposing to complications. We analysed complication rates after VATS lobectomy in a prospectively maintained nationwide registry.METHODSThe registry was queried for all consecutive VATS lobectomy procedures from 49 Italian Thoracic Units. Baseline condition, tumour features, surgical techniques, devices, postoperative care, complications, conversions and the reasons thereof were detailed. Univariable and multivariable regressions were used to assess factors potentially linked to complications.RESULTSFour thousand one hundred and ninety-one VATS lobectomies in 4156 patients (2480 men, 1676 women) were analysed. The median age-adjusted Charlson index of the patients was 4 (interquartile range 3–6). Grade 1 and 2 and Grade 3–5 complications were observed in 20.1% and in 5.8%, respectively. Ninety-day mortality was 0.55%. The overall conversion rate was 9.2% and significantly higher in low-volume centres (CONCLUSIONSVATS lobectomy is a safe procedure even in medically compromised patients. An improved classification system for conversions is proposed and prevention strategies are suggested to reduce conversion rates and possibly complications in less-experienced centres.

Published
2019

48. The CiTAS scale for evaluating taste alteration induced by chemotherapy: State of the art on its clinical use

Author

Simeone S., Esposito M. R., Gargiulo G., Lanzuise A., Botti S., Serra N., Continisio G. I., Rea T., Guillari A., Simeone, S., Esposito, M. R., Gargiulo, G., Lanzuise, A., Botti, S., Serra, N., Continisio, G. I., Rea, T., and Guillari, A.

Subjects
CiTAS scale, Chemotherapy effect, Cancer patient, Taste alteration, Nutrition
Abstract

Cancer is the leading cause of death worldwide. Of the various therapeutic approaches, chemotherapy is the most widely used treatment. Among the various side effects associated with this treatment, taste alterations (TAs) have received little attention, even though they have a serious impact on the nutritional aspect and quality of life (QoL) of patients. TAs concern 75% of the patients receiving chemotherapy, and this figure is still considered to be underestimatedbeacuse could be due both to inadequate attention and to the absence of specific subjective tools able to fully evaluate TAs in patients undergoing chemotherapy.

Published
2019

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