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4. Lung recruitment before surfactant administration in extremely preterm neonates with respiratory distress syndrome (IN-REC-SUR-E): a randomised, unblinded, controlled trial

Author

Vento, Giovanni, Ventura, Maria Luisa, Pastorino, Roberta, van Kaam, Anton H, Carnielli, Virgilio, Cools, Filip, Dani, Carlo, Mosca, Fabio, Polglase, Graeme, Tagliabue, Paolo, Boni, Luca, Cota, Francesco, Tana, Milena, Tirone, Chiara, Aurilia, Claudia, Lio, Alessandra, Costa, Simonetta, D'Andrea, Vito, Lucente, Mariella, Nigro, Gabriella, Giordano, Lucio, Roma, Vincenzina, Villani, Paolo E, Fusco, Francesca P, Fasolato, Valeria, Colnaghi, Maria Rosa, Matassa, Piero G, Vendettuoli, Valentina, Poggi, Chiara, Del Vecchio, Antonio, Petrillo, Flavia, Betta, Pasqua, Mattia, Carmine, Garani, Giampaolo, Solinas, Agostina, Gitto, Eloisa, Salvo, Vincenzo, Gargano, Giancarlo, Balestri, Eleonora, Sandri, Fabrizio, Mescoli, Giovanna, Martinelli, Stefano, Ilardi, Laura, Ciarmoli, Elena, Di Fabio, Sandra, Maranella, Eugenia, Grassia, Carolina, Ausanio, Gaetano, Rossi, Vincenzo, Motta, Angela, Tina, Lucia G, Maiolo, Kim, Nobile, Stefano, Messner, Hubert, Staffler, Alex, Ferrero, Federica, Stasi, Ilaria, Pieragostini, Luisa, Mondello, Isabella, Haass, Cristina, Consigli, Chiara, Vedovato, Stefania, Grison, Alessandra, Maffei, Gianfranco, Presta, Giuseppe, Perniola, Roberto, Vitaliti, Marcello, Re, Maria P, De Curtis, Mario, Cardilli, Viviana, Lago, Paola, Tormena, Francesca, Orfeo, Luigi, Gizzi, Camilla, Massenzi, Luca, Gazzolo, Diego, Strozzi, Maria Chiara M, Bottino, Roberto, Pontiggia, Federica, Berardi, Alberto, Guidotti, Isotta, Cacace, Caterina, Meli, Valerio, Quartulli, Lorenzo, Scorrano, Antonio, Casati, Alessandra, Grappone, Lidia, and Pillow, J Jane

Published
2021
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5. A Bizarre Commonly Unrecognized Simply Treatable Dermatosis.

Author

Manfredi, Marco, Maffini, Valentina, Gismondi, Pierpacifico, and Gargano, Giancarlo

Subjects
SKIN disease diagnosis, NECK, PHYSICAL diagnosis, PARAFFIN wax, ANTIFUNGAL agents, SKIN diseases, DIFFERENTIAL diagnosis, SELF-neglect, TREATMENT effectiveness, ITALIANS, PEDIATRICS, CLINICS, SURGICAL dressings, HYPERPIGMENTATION, SYMPTOMS
Abstract

The article focuses on terra firma-forme dermatosis (TFFD), a benign and often unrecognized skin condition in children characterized by brown-grayish patches that resemble dirt. Topics include the common occurrence of skin disorders in pediatric exams, the presentation and distribution of TFFD, and the unknown pathogenesis and clinical features of this condition.

Published
2024
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7. Patent ductus arteriosus (also non-hemodynamically significant) correlates with poor outcomes in very low birth weight infants. A multicenter cohort study.

Author

Chesi, Elena, Rossi, Katia, Ancora, Gina, Baraldi, Cecilia, Corradi, Mara, Di Dio, Francesco, Di Fazzio, Giorgia, Galletti, Silvia, Mescoli, Giovanna, Papa, Irene, Solinas, Agostina, Braglia, Luca, Di Caprio, Antonella, Cuoghi Costantini, Riccardo, Miselli, Francesca, Berardi, Alberto, and Gargano, Giancarlo

Subjects
LOW birth weight, VERY low birth weight, PREMATURE infants, PATENT ductus arteriosus, COHORT analysis, BIRTH weight
Abstract

Objectives: To standardize the diagnosis of patent ductus arteriosus (PDA) and report its association with adverse neonatal outcomes in very low birth weight infants (VLBW, birth weight < 1500 g). Study design: A multicenter prospective observational study was conducted in Emilia Romagna from March 2018 to October 2019. The association between ultrasound grading of PDA and adverse neonatal outcomes was evaluated after correction for gestational age. A diagnosis of hemodynamically significant PDA (hsPDA) was established when the PDA diameter was ≥ 1.6 mm at the pulmonary end with growing or pulsatile flow pattern, and at least 2 of 3 indexes of pulmonary overcirculation and/or systemic hypoperfusion were present. Results: 218 VLBW infants were included. Among infants treated for PDA closure in the first postnatal week, up to 40% did not have hsPDA on ultrasound, but experienced clinical worsening. The risk of death was 15 times higher among neonates with non-hemodynamically significant PDA (non-hsPDA) compared to neonates with no PDA. In contrast, the risk of death was similar between neonates with hsPDA and neonates with no PDA. The occurrence of BPD was 6-fold higher among neonates with hsPDA, with no apparent beneficial role of early treatment for PDA closure. The risk of IVH (grade ≥ 3) and ROP (grade ≥ 3) increased by 8.7-fold and 18-fold, respectively, when both systemic hypoperfusion and pulmonary overcirculation were present in hsPDA. Conclusions: The increased risk of mortality in neonates with non-hsPDA underscores the potential inadequacy of criteria for defining hsPDA within the first 3 postnatal days (as they may be adversely affected by other clinically severe factors, i.e. persistent pulmonary hypertension and mechanical ventilation). Parameters such as length, diameter, and morphology may serve as more suitable ultrasound indicators during this period, to be combined with clinical data for individualized management. Additionally, BPD, IVH (grade ≥ 3) and ROP (grade ≥ 3) are associated with hsPDA. The existence of an optimal timeframe for closing PDA to minimize these adverse neonatal outcomes remains uncertain. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Exposure to Gastric Acid Inhibitors Increases the Risk of Infection in Preterm Very Low Birth Weight Infants but Concomitant Administration of Lactoferrin Counteracts This Effect

Author

Di Comite, Amelia, Borghesi, Alessandro, Tzialla, Chryssoula, Agriesti, Giovanni, Arisio, Riccardo, Franco, Caterina, Guardione, Roberta, Boano, Elena, Catarinella, Alessia, Romano, Cristina, Monetti, Cesare, Sala, Ugo, Carbonara, Caterina, Mastretta, Emmanuele, Del Sordo, Paola, Priolo, Claudio, Galletto, Paolo, Campagnoli, Francesca, Vivalda, Mauro, Bonfante, Giuseppina, Gomirato, Giovanna, Montin, Davide, Camilla, Roberta, Messina, Alessandro, Pieretto, Marta, Cipolla, Domenico, Giuffrè, Mario, Corsello, Giovanni, Natale, Fabio, Vetrano, Gennaro, Tridapalli, Elisabetta, Faldella, Giacomo, Grazia Capretti, Maria, Paolillo, PierMichele, Picone, Simonetta, Lacerenza, Serafina, Gargano, Giancarlo, Magnani, Cristiana, Sergio Saia, Onofrio, Della Casa, Elena, Manzoni, Paolo, García Sánchez, Ruben, Meyer, Michael, Stolfi, Ilaria, Pugni, Lorenza, Messner, Hubert, Cattani, Silvia, Betta, Pasqua Maria, Memo, Luigi, Decembrino, Lidia, Bollani, Lina, Rinaldi, Matteo, Fioretti, Maria, Quercia, Michele, Maule, Milena, Tavella, Elena, Mussa, Alessandro, Laforgia, Nicola, Mosca, Fabio, Magaldi, Rosario, Mostert, Michael, and Farina, Daniele

Published
2018
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11. Admission Hypothermia in Very Preterm Infants and Neonatal Mortality and Morbidity

Author

Van Reempts, Patrick, Martens, Evelyne, Martens, Guy, Pryds, Ole, Boerch, Klaus, Hasselager, Asbjoern, Huusom, Lene, Weber, Tom, Toome, Liis, Varendi, Heili, Truffert, Patrick, Jarreau, Pierre-Henri, Ancel, Pierre-Yves, Blondel, Beatrice, Burguet, Antoine, Schmidt, Stephan, Gortner, Ludwig, Cuttini, Marina, Croci, Ileana, Baronciani, Dante, Gargano, Giancarlo, Carnielli, Virgilio, Di Lallo, Domenico, Agostino, Rocco, Franco, Francesco, Koopman-Esseboom, Corine, Nijman, Joppe, van Heijst, Arno, Gadzinowski, Janusz, Mazela, Jan, Graça, Luis M., Ceu Machado, Maria, Carapato, Rui, Barros, Henrique, Rodrigues, Carina, Rodrigues, Teresa, Draper, Elizabeth, Boyle, Elaine M., Manktelow, Brad, Milligan, David W.A., Fenton, Alan, Wilson, Emilija, Maier, Rolf F., Norman, Mikael, Misselwitz, Bjoern, Howell, Elizabeth A., Zeitlin, Jennifer, and Bonamy, Anna-Karin

Published
2016
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14. Prenatal Clinical Findings in RASA1-Related Capillary Malformation-Arteriovenous Malformation Syndrome

Author

Coccia, Emanuele, primary, Valeri, Lara, additional, Zuntini, Roberta, additional, Caraffi, Stefano Giuseppe, additional, Peluso, Francesca, additional, Pagliai, Luca, additional, Vezzani, Antonietta, additional, Pietrangiolillo, Zaira, additional, Leo, Francesco, additional, Melli, Nives, additional, Fiorini, Valentina, additional, Greco, Andrea, additional, Lepri, Francesca Romana, additional, Pisaneschi, Elisa, additional, Marozza, Annabella, additional, Carli, Diana, additional, Mussa, Alessandro, additional, Radio, Francesca Clementina, additional, Conti, Beatrice, additional, Iascone, Maria, additional, Gargano, Giancarlo, additional, Novelli, Antonio, additional, Tartaglia, Marco, additional, Zuffardi, Orsetta, additional, Bedeschi, Maria Francesca, additional, and Garavelli, Livia, additional

Published
2023
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15. Monitoring of Auditory Function in Newborns of Women Infected by SARS-CoV-2 during Pregnancy

Author

Apa, Enrico, primary, Presutti, Maria Teresa, additional, Rossi, Cecilia, additional, Roversi, Maria Federica, additional, Neri, Salvatore, additional, Gargano, Giancarlo, additional, Bianchin, Giovanni, additional, Polizzi, Valeria, additional, Caragli, Valeria, additional, Monzani, Daniele, additional, Berardi, Alberto, additional, Palma, Silvia, additional, and Genovese, Elisabetta, additional

Published
2023
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17. Fulminant Sepsis and Perinatal Death at 23 Weeks Due to Fusobacterium nucleatum

Author

Bonasoni, Maria Paola, primary, Comitini, Giuseppina, additional, Pati, Mariangela, additional, Bardaro, Marcellino, additional, Russello, Giuseppe, additional, Carretto, Edoardo, additional, Dalla Dea, Giulia, additional, Palicelli, Andrea, additional, Bernardelli, Giuditta, additional, Chesi, Elena, additional, and Gargano, Giancarlo, additional

Published
2022
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18. Fulminant Sepsis and Perinatal Death at 23 Weeks Due to Fusobacterium nucleatum.

Author

Bonasoni, Maria Paola, Comitini, Giuseppina, Pati, Mariangela, Bardaro, Marcellino, Russello, Giuseppe, Carretto, Edoardo, Dalla Dea, Giulia, Palicelli, Andrea, Bernardelli, Giuditta, Chesi, Elena, and Gargano, Giancarlo

Subjects
PREMATURE rupture of fetal membranes, CHORIOAMNIONITIS, PERINATAL death, FUSOBACTERIUM, DENTAL hygiene, SEPSIS, PERIODONTAL disease
Abstract

Introduction:Fusobacterium nucleatum is a gram-negative anaerobe, a constituent of the oral microflora, responsible for chronic periodontal diseases. Case Report: We describe a preterm infant with premature rupture of membranes at 23 weeks of gestational age due to F. nucleatum. The newborn died soon after birth. Placental histopathology showed severe necrotizing chorioamnionitis and funisitis with gram-negative bacilli. After autopsy, F. nucleatum was microbiologically isolated from the lung. The mother had dental hygiene 1 day before delivery, presenting mild and diffuse gingivitis. At admission, she had leukocytosis, foul-smelling vaginal discharge, but no fever. Conclusion: This case highlights the possibility of F. nucleatum spreading from oral cavity after a dental procedure to the placenta with chorioamnionitis and fetal infection. This raises the question of whether dental procedures during pregnancy should be accompanied by prophylactic antibiotics. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Delivery indication matters for perinatal outcomes in late preterm newborns

Author

Monari, Francesca, Chiossi, Giuseppe, Gargano, Giancarlo, Ballarini, Michela, Baronciani, Dante, Coscia, Alessandra, and Facchinetti, Fabio

Subjects
Fetal Membranes, Premature Rupture, medical indication, Late preterm, p PROM, perinatal outcomes, Infant, Newborn, Parturition, Pregnancy Outcome, Obstetrics and Gynecology, Infant, Gestational Age, Pregnancy, Pediatrics, Perinatology and Child Health, Humans, Premature Birth, Female, Prospective Studies, Retrospective Studies
Abstract

The late preterm (LP) rate in Western countries is 3–6% of all births, accounting for about two-thirds of the entire preterm population. However, all LP babies are not the same. To identify pregnancies at risk for adverse outcomes in the LP period, we investigated how gestational age (GA) at delivery, delivery indication and prenatal risk factors may affect neonatal outcomes. Prospective cohort study among singleton infants born between 34 + 0 and 36 + 6 weeks, in Emilia Romagna, Italy, during 2013–2015. The primary outcome was a composite of adverse perinatal outcomes. Multivariate logistic regression models were used to, respectively, investigate the effects of GA at delivery, circumstances at parturition and prenatal risk factors, on study outcomes after controlling for confounding variable. Among 1867 births, 302, 504, and 1061 infants were born at 34, 35, and 36 weeks, respectively. There were no neonatal deaths. An increased risk of composite neonatal outcome was observed among 34 and 35 weeks deliveries compared with 36 weeks, and among indicated deliveries compared with spontaneous. When studying prenatal risk factors, neonatal morbidity was associated with pre gestational diabetes, preterm premature rupture of membranes (pPROM), maternal obesity, bleeding and polyhydramnios; instead, preeclampsia had a protective effect. LP with indicated deliveries at 34 or 35 weeks, or with specific prenatal risk factors have worse neonatal outcome when compared to 36. Such differences should be considered when counseling patients and planning interventions such as timing of delivery in LP period.

Published
2022
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22. Clinical and Genetic Findings in a Series of Eight Families with Arthrogryposis

Author

Pollazzon, Marzia, primary, Caraffi, Stefano Giuseppe, additional, Faccioli, Silvia, additional, Rosato, Simonetta, additional, Fodstad, Heidi, additional, Campos-Xavier, Belinda, additional, Soncini, Emanuele, additional, Comitini, Giuseppina, additional, Frattini, Daniele, additional, Grimaldi, Teresa, additional, Marinelli, Maria, additional, Martorana, Davide, additional, Percesepe, Antonio, additional, Sassi, Silvia, additional, Fusco, Carlo, additional, Gargano, Giancarlo, additional, Superti-Furga, Andrea, additional, and Garavelli, Livia, additional

Published
2021
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26. Posterior Lissencephaly Associated with Subcortical Band Heterotopia Due to a Variation in the CEP85L Gene: A Case Report and Refining of the Phenotypic Spectrum

Author

Contrò, Gianluca, primary, Micalizzi, Alessia, additional, Giangiobbe, Sara, additional, Caraffi, Stefano Giuseppe, additional, Zuntini, Roberta, additional, Rosato, Simonetta, additional, Pollazzon, Marzia, additional, Terracciano, Alessandra, additional, Napoli, Manuela, additional, Rizzi, Susanna, additional, Salerno, Grazia Gabriella, additional, Radio, Francesca Clementina, additional, Niceta, Marcello, additional, Parrini, Elena, additional, Fusco, Carlo, additional, Gargano, Giancarlo, additional, Guerrini, Renzo, additional, Tartaglia, Marco, additional, Novelli, Antonio, additional, Zuffardi, Orsetta, additional, and Garavelli, Livia, additional

Published
2021
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27. Whole Exome Sequencing Is the Minimal Technological Approach in Probands Born to Consanguineous Couples

Author

Peluso, Francesca, primary, Caraffi, Stefano Giuseppe, additional, Zuntini, Roberta, additional, Trimarchi, Gabriele, additional, Ivanovski, Ivan, additional, Valeri, Lara, additional, Barbieri, Veronica, additional, Marinelli, Maria, additional, Pancaldi, Alessia, additional, Melli, Nives, additional, Cesario, Claudia, additional, Agolini, Emanuele, additional, Cellini, Elena, additional, Radio, Francesca Clementina, additional, Crisafi, Antonella, additional, Napoli, Manuela, additional, Guerrini, Renzo, additional, Tartaglia, Marco, additional, Novelli, Antonio, additional, Gargano, Giancarlo, additional, Zuffardi, Orsetta, additional, and Garavelli, Livia, additional

Published
2021
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28. Adducted Thumb and Peripheral Polyneuropathy: Diagnostic Supports in Suspecting White–Sutton Syndrome: Case Report and Review of the Literature

Author

Trimarchi, Gabriele, primary, Caraffi, Stefano Giuseppe, additional, Radio, Francesca Clementina, additional, Barresi, Sabina, additional, Contrò, Gianluca, additional, Pizzi, Simone, additional, Maini, Ilenia, additional, Pollazzon, Marzia, additional, Fusco, Carlo, additional, Sassi, Silvia, additional, Nicoli, Davide, additional, Napoli, Manuela, additional, Pascarella, Rosario, additional, Gargano, Giancarlo, additional, Zuffardi, Orsetta, additional, Tartaglia, Marco, additional, and Garavelli, Livia, additional

Published
2021
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29. Simpson–Golabi–Behmel syndrome type 1 in a 27-week macrosomic preterm newborn: The diagnostic value of rib malformations and index nail and finger hypoplasia

Author

Garavelli, Livia, Gargano, Giancarlo, Simonte, Graziella, Rosato, Simonetta, Wischmeijer, Anita, Melli, Nives, Braibanti, Silvia, Gelmini, Chiara, Forzano, Francesca, Pietrobono, Roberta, Pomponi, Maria Grazia, Andreucci, Elena, Toutain, Annick, Superti-Furga, Andrea, and Neri, Giovanni

Published
2012
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33. Additional file 1 of Neuroprem: the Neuro-developmental outcome of very low birth weight infants in an Italian region

Author

Lugli, Licia, Pugliese, Marisa, Plessi, Carlotta, Berardi, Alberto, Guidotti, Isotta, Ancora, Gina, Grandi, Sara, Gargano, Giancarlo, Braibanti, Silvia, Sandri, Fabrizio, Soffritti, Silvia, Ballardini, Elisa, Arena, Vittoria, Stella, Marcello, Perrone, Serafina, Moretti, Sabrina, Rizzo, Vittoria, Ferrari, Fabrizio, Picciolini, Odoardo, Bellù, Roberto, Turoli, Daniela, Corvaglia, Luigi, Garani, Gianpaolo, Paoletti, Vittoria, Biasucci, Giacomo, Biasini, Augusto, Benenati, Belinda, Stagi, Paolo, Magnani, Cristina, Dallaglio, Sara, Muttini, Elisa DellaCasa, Roversi, Maria, Bedetti, Luca, Lucaccioni, Laura, Bertoncelli, Natascia, and Boncompagni, Alessandra

Abstract

Additional file 1. Appendix A Neuro-functional clinical evaluation

Published
2020
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34. A monoallelic SEC23A variant E599K associated with cranio‐lenticulo‐sutural dysplasia.

Author

Cisarova, Katarina, Garavelli, Livia, Caraffi, Stefano Giuseppe, Peluso, Francesca, Valeri, Lara, Gargano, Giancarlo, Gavioli, Sara, Trimarchi, Gabriele, Neri, Alberto, Campos‐Xavier, Belinda, and Superti‐Furga, Andrea

Abstract

Cranio‐lenticulo‐sutural dysplasia (CLSD; MIM 607812) is a rare or underdiagnosed condition, as only two families have been reported. The original family (Boyadjiev et al., Human Genetics, 2003, 113, 1–9 and Boyadjiev et al., Nature Genetics, 2006, 38, 1192–1197) showed recessive inheritance of the condition with a biallelic SEC23A missense variant in affected individuals. In contrast, another child with sporadic CLSD had a monoallelic SEC23A variant inherited from the reportedly unaffected father (Boyadjiev et al., Clinical Genetics, 2011, 80, 169–176), raising questions on possible digenism. Here, we report a 2‐month‐old boy seen because of large fontanels with wide cranial sutures, a large forehead, hypertelorism, a thin nose, a high arched palate, and micrognathia. His mother was clinically unremarkable, while his father had a history of large fontanels in infancy who had closed only around age 10 years; he also had a large forehead, hypertelorism, a thin, beaked nose and was operated for bilateral glaucoma with exfoliation of the lens capsule. Trio genome sequencing and familial segregation revealed a monoallelic c.1795G > A transition in SEC23A that was de novo in the father and transmitted to the proband. The variant predicts a nonconservative substitution (p.E599K) in an ultra‐conserved residue that is seen in 3D models of yeast SEC23 to be involved in direct binding between SEC23 and SAR1 subunits of the coat protein complex II coat. This observation confirms the link between SEC23A variants and CLSD but suggests that in addition to the recessive inheritance described in the original family, SEC23A variants may result in dominant inheritance of CLSD, possibly by a dominant‐negative disruptive effect on the SEC23 multimer. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Association of Short Antenatal Corticosteroid Administration-to-Birth Intervals With Survival and Morbidity Among Very Preterm Infants: Results From the EPICE Cohort

Author

Norman, Mikael, Piedvache, Aurelie, Børch, Klaus, Huusom, Lene Drasbek, Bonamy, Anna Karin Edstedt, Howell, Elizabeth A., Jarreau, Pierre Henri, Maier, Rolf F., Pryds, Ole, Toome, Liis, Varendi, Heili, Weber, Tom, Wilson, Emilija, van Heijst, Arno, Cuttini, Marina, Mazela, Jan, Barros, Henrique, Van Reempts, Patrick, Draper, Elizabeth S., Zeitlin, Jennifer, Martens, Evelyne, Martens, Guy, Hasselager, Asbjoern, Ancel, Pierre Yves, Blondel, Béatrice, Bonet, Mercedes, Burguet, Antoine, Truffert, Patrick, Misselwitz, Bjoern, Schmidt, Stephan, Gortner, Ludvig, Baronciani, Dante, Gargano, Giancarlo, Agostino, Rocco, DiLallo, Domenico, Franco, Francesco, Carnielli, Virgilio, Croci, Ileana, Koopman-Esseboom, Corrine, Nijman, Joppe, Gadzinowski, Janusz, Graça, Luís Mendes, Do Céu Machado, Maria, Rodrigues, Carina, Ribeiro-Rodrigues, Teresa, Boyle, Elaine M., Manktelow, Brad N., Fenton, Alan C., Effective Perinatal Intensive Care, Instituto de Saúde Pública, and EPICE Res Grp

Subjects
Male, Pediatrics, Infant, Premature, Diseases, Cohort Studies, 0302 clinical medicine, Pregnancy, Infant Mortality, Hospital Mortality, Prospective Studies, Prospective cohort study, Original Investigation, 030219 obstetrics & reproductive medicine, Gestational age, Obstetrics and Gynecology, Prenatal Care, General Medicine, Perinatology, 3. Good health, Europe, and Child Health, Multicenter Study, Obstetrics, Premature birth, Infant, Extremely Premature, Necrotizing enterocolitis, Female, Infant, Premature, Cohort study, Antenatal corticosteroids, medicine.medical_specialty, Birth weight, Gestational Age, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], 03 medical and health sciences, Birth Intervals, 030225 pediatrics, Intensive care, Journal Article, medicine, Humans, Pediatrics, Perinatology, and Child Health, Neonatology, Glucocorticoids, business.industry, Infant, Newborn, Infant, medicine.disease, Pediatrics, Perinatology and Child Health, Human medicine, business
Abstract

Administration-to-birth intervals of antenatal corticosteroids (ANS) vary. The significance of this variation is unclear. Specifically, to our knowledge, the shortest effective administration-to-birth interval is unknown. Objective:To explore the associations between ANS administration-to-birth interval and survival and morbidity among very preterm infants. Design, Setting, and Participants: The Effective Perinatal Intensive Care in Europe (EPICE) study, a population-based prospective cohort study, gathered data from 19 regions in 11 European countries in 2011 and 2012 on 4594 singleton infants with gestational ages between 24 and 31 weeks, without severe anomalies and unexposed to repeated courses of ANS. Data were analyzed November 2016. Exposure: Time from first injection of ANS to delivery in hours and days. Main Outcomes and Measures: Three outcomes were studied: in-hospital mortality; a composite of mortality or severe neonatal morbidity, defined as an intraventricular hemorrhage grade of 3 or greater, cystic periventricular leukomalacia, surgical necrotizing enterocolitis, or stage 3 or greater retinopathy of prematurity; and severe neonatal brain injury, defined as an intraventricular hemorrhage grade of 3 or greater or cystic periventricular leukomalacia. Results: Of the 4594 infants included in the cohort, 2496 infants (54.3%) were boys, and the mean (SD) gestational age was 28.5 (2.2) weeks and mean (SD) birth weight was 1213 (400) g. Mortality for the 662 infants (14.4%) unexposed to ANS was 20.6% (136 of 661). Administration of ANS was associated with an immediate and rapid decline in mortality, reaching a plateau with more than 50% risk reduction after an administration-to-birth interval of 18 to 36 hours. A similar pattern for timing was seen for the composite mortality or morbidity outcome, whereas a significant risk reduction of severe neonatal brain injury was associated with longer administration-to-birth intervals (greater than 48 hours). For all outcomes, the risk reduction associated with ANS was transient, with increasing mortality and risk for severe neonatal brain injury associated with administration-to-birth intervals exceeding 1 week. Under the assumption of a causal relationship between timing of ANS and mortality, a simulation of ANS administered 3 hours before delivery to infants who did not receive ANS showed that their estimated decline in mortality would be 26%. Conclusions and Relevance:Antenatal corticosteroids may be effective even if given only hours before delivery. Therefore, the infants of pregnant women at risk of imminent preterm delivery may benefit from its use. The research received funding from grant agreement 259882 from the European Union Seventh Framework Program (2007-2013). Additional funding in France was provided by the French Institute of Public Health Research/Institute of Public Health and its partners, including the French Health Ministry, the National Institute of Health and Medical Research, the National Institute of Cancer, and the National Solidarity Fund for Autonomy, by grant ANR-11-EQPX-0038 from the National Research Agency through the French Equipex Program of Investments in the Future, and by the PremUp Foundation; in Poland, by 2012-2015 allocation of funds for international projects from the Polish Ministry of Science and HigherEducation; and in Sweden, by regional agreementon medical training and clinical research betweenStockholm County Council and Karolinska Institutetand by the Department of Neonat al Medicine at theKarolinska University Hospital.

Published
2017

36. Low socio‐economic conditions and prematurity‐related morbidities explain healthcare use and costs for 2‐year‐old very preterm children

Author

Meregaglia, Michela, primary, Croci, Ileana, additional, Brusco, Carla, additional, Herich, Lena C., additional, Di Lallo, Domenico, additional, Gargano, Giancarlo, additional, Carnielli, Virgilio, additional, Zeitlin, Jennifer, additional, Fattore, Giovanni, additional, and Cuttini, Marina, additional

Published
2020
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39. Bifidobacterium bifidum and the infant gut microbiota: an intriguing case of microbe‐host co‐evolution

Author

Duranti, Sabrina, primary, Lugli, Gabriele Andrea, additional, Milani, Christian, additional, James, Kieran, additional, Mancabelli, Leonardo, additional, Turroni, Francesca, additional, Alessandri, Giulia, additional, Mangifesta, Marta, additional, Mancino, Walter, additional, Ossiprandi, Maria Cristina, additional, Iori, Alexandra, additional, Rota, Claudio, additional, Gargano, Giancarlo, additional, Bernasconi, Sergio, additional, Di Pierro, Francesco, additional, Sinderen, Douwe, additional, and Ventura, Marco, additional

Published
2019
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40. Stewardship antimicrobica nel neonato e nel piccolo lattante: Perché e come praticarla

Author

Berardi, Alberto, Ficara, Monica, Pietrella, Elisa, Boncompagni, Alessandra, Toffoli, Carlotta, Bianchini, Anastasia, Della Casa, Elisa, Spada, Caterina, Spaggiari, Eugenio, Ciccia, Matilde, Gargano, Giancarlo, Rizzo, Vittoria, Azzalli, Milena, Biasucci, Giacomo, Gambini, Lucia, Bolognesi, Serenella, Ferrari, Fabrizio, Memo, L., Nicolini, G., Ciccia, M., Sandri, F., Capretti, M. G., Dondi, A., Pasini, L., Ragni, L., Albarelli, A., Fiorini, V., Giugno, C., Lanzoni, P., Di Grande, E., Polese, A., China, M. C., Rizzo, V., Stella, M., Zucchini, A., Malaguti, L., Azzalli, M., Garani, G., Nasi, S., Bacchini, P., Fragni, G., Baldassarri, P., Pulvirenti, R. M., Valletta, E., Bidetti, M. L., Incerti, S. Storchi, Di Carlo, C., Lanzoni, A., Serra, L., Silvestrini, D., Berardi, A., Ferrari, F., Lugli, L., Venturelli, C., Sarti, M., Volta, A., Dodi, I., Magnani, C., Guidi, B., Biasucci, G., Chiarabini, R., De Paulis, N., Padrini, D., Riboni, S., Pedna, M. F., Casadio, L., Marchetti, F., Muratori, C., Piccinini, G., Renzelli, C., Amarri, S., Baroni, L., Carretto, E., Gargano, G., Pedori, S., Riva, M., Zuelli, C., Ancona, G., Bolognesi, S., Vergine, G., Viola, L., Chiossi, C., Pagano, R., Zanacca, C., Palmieri, R., PICCININI, GIANCARLO, BASTELLI, ANNALISA, AMBRETTI, SIMONE, CORVAGLIA, LUIGI TOMMASO, LANARI, MARCELLO, LAMA, CARLA, VENTUROLI, VINCENZO, ALESSANDRINI, CATERINA, FACCHINETTI, FABRIZIO, GAMBINI, LUIGI, BERTELLI, MICHELE, SAMBRI, VITTORIO, FORNACIARI, SILVIA, PAPA, IRENE, RIVI, CLAUDIA, BONVICINI, CARLOTTA, Berardi, Alberto, Ficara, Monica, Pietrella, Elisa, Boncompagni, Alessandra, Toffoli, Carlotta, Bianchini, Anastasia, Della Casa, Elisa, Spada, Caterina, Spaggiari, Eugenio, Ciccia, Matilde, Gargano, Giancarlo, Rizzo, Vittoria, Azzalli, Milena, Biasucci, Giacomo, Gambini, Lucia, Bolognesi, Serenella, Piccinini, Giancarlo, Ferrari, Fabrizio, Memo, L., Nicolini, G., Ciccia, M., Bastelli, A., Sandri, F., Ambretti, S., Capretti, M. G., Corvaglia, L., Dondi, A., Lanari, M., Pasini, L., Ragni, L., Albarelli, A., Fiorini, V., Giugno, C., Lanzoni, P., Di Grande, E., Polese, A., China, M. C., Rizzo, V., Stella, M., Zucchini, A., Malaguti, L., Azzalli, M., Garani, G., Lama, C., Nasi, S., Bacchini, P., Fragni, G., Baldassarri, P., Pulvirenti, R. M., Valletta, E., Venturoli, V., Alessandrini, C., Bidetti, M. L., Incerti, S. Storchi, Di Carlo, C., Lanzoni, A., Serra, L., Silvestrini, D., Berardi, A., Facchinetti, F., Ferrari, F., Lugli, L., Venturelli, C., Sarti, M., Volta, A., Dodi, I., Gambini, L., Magnani, C., Guidi, B., Bertelli, M., Biasucci, G., Chiarabini, R., De Paulis, N., Padrini, D., Riboni, S., Pedna, M. F., Sambri, V., Casadio, L., Marchetti, F., Muratori, C., Piccinini, G., Renzelli, C., Amarri, S., Baroni, L., Carretto, E., Fornaciari, S., Gargano, G., Pedori, S., Riva, M., Zuelli, C., Ancona, G., Bolognesi, S., Papa, I., Vergine, G., Viola, L., Chiossi, C., Pagano, R., Rivi, C., Zanacca, C., Bonvicini, C., and Palmieri, R.

Subjects
Sepsi, Pediatrics, Perinatology and Child Health, Antibiotic, Antimicrobial stewardship, Prophylaxi, Infection, Newborn
Abstract

Antimicrobial resistances are increasing worldwide, due to the misuse of antibiotic therapies in humans as well as in animals. It is expected that within a few decades multi-resistant pathogens will become the leading cause of death worldwide. The misuse of antibiotics in the neonatal period depends on the lack of predictive diagnostic tests and the peculiarity of symptoms of sepsis, which frequently are vague and unspecific at the time of presentation. Policies to prevent the emergence of antimicrobial resistances rely on a judicious use of antibiotics, on protocols and additional measures shared by health care providers. This document summarizes recent indications issued in the Emilia-Romagna subsequent to a review of the literature.

Published
2017

41. The burden of early-onset sepsis in Emilia-Romagna (Italy): a 4-year, population-based study

Author

Berardi, Alberto, Baroni, Lorenza, Bacchi Reggiani, Maria Letizia, Ambretti, Simone, Biasucci, Giacomo, Bolognesi, Serenella, Capretti, Maria Grazia, Carretto, Edoardo, Ciccia, Matilde, Fiorini, Valentina, Fortini, Cinzia, Gargano, Giancarlo, Pedna, Maria Federica, Rizzo, Vittoria, Creti, Roberta, Ferrari, Fabrizio, Memo, L., Nicolini, G., Campanile, A., Tridapalli, E., Ciccia, M., Bastelli, A., Sandri, F., Ambretti, S., Capretti, M. G., Gentili, A., Ragni, L., Albarelli, A., Piscina, A., Borghi, A., Simoni, A., Fiorini, V., Grande, E. D., Polese, A., Biasini, A., China, M. C., Rizzo, V., Zucchini, A., Malaguti, L., Contiero, R., Fortini, C., Garani, G., Rossi, M. R., Nasi, S., Bacchini, P., Baldassarri, P., Pulvirenti, R. M., Vaienti, F., Venturoli, V., Bidetti, M. L., Colla, R., Toniato, M., Carlo, C. D., Lanari, M., Serra, L., Silvestrini, D., Facchinetti, F., Ferrari, F., Lugli, L., Venturelli, C., Sarti, M., Volta, A., Dodi, I., Gambini, L., Guidi, B., Bertelli, M., Biasucci, G., Chiarabini, R., Padrini, D., Piepoli, M., Riboni, S., Rubbi, P., Pedna, M. F., Sambri, V., Perrone, A., Preti, P., Marchetti, F., Piccinini, G. C., Amarri, S., Carretto, E., Gargano, G., Pedori, S., Riva, M., Rossi, C., Zuelli, C., Bolognesi, S., Papa, I., Vergine, G., Viola, L., Chiossi, C., Pagano, R., Zanacca, C., Palmieri, R., Berardi, Alberto, Baroni, Lorenza, Bacchi Reggiani, Maria Letizia, Ambretti, Simone, Biasucci, Giacomo, Bolognesi, Serenella, Capretti, Maria Grazia, Carretto, Edoardo, Ciccia, Matilde, Fiorini, Valentina, Fortini, Cinzia, Gargano, Giancarlo, Pedna, Maria Federica, Rizzo, Vittoria, Creti, Roberta, Ferrari, Fabrizio, and GBS Prevention Working Group Emilia-Romagna [,Lanari, Marcello,]

Subjects
Pediatrics, Antibiotics, group B streptococcu, Logistic regression, medicine.disease_cause, Severity of Illness Index, Group B, 0302 clinical medicine, Risk Factors, Medicine, Birth Weight, 030212 general & internal medicine, Escherichia coli Infections, Streptococcus, Gestational age, meningitis, Obstetrics and Gynecology, Drug Resistance, Microbial, intrapartum chemoprophylaxi, Perinatology and Child Health, meningiti, Anti-Bacterial Agents, Italy, Regression Analysis, Neonatal Sepsis, Meningitis, Early-onset sepsis, group B streptococcus, intrapartum chemoprophylaxis, newborn infant, Pediatrics, Perinatology and Child Health, Infant, Premature, Cohort study, medicine.medical_specialty, medicine.drug_class, Statistics, Nonparametric, Streptococcus agalactiae, Sepsis, 03 medical and health sciences, 030225 pediatrics, Streptococcal Infections, Escherichia coli, Humans, Retrospective Studies, business.industry, Infant, Newborn, Infant, medicine.disease, Early-onset sepsi, Ampicillin, Gentamicins, business
Abstract

Objective: To provide the first Italian data on pathogens causing early-onset sepsis (EOS) and their antimicrobial susceptibility, after the successfully prevention of Group B streptococcus (GBS) EOS. Methods: Retrospective area-based cohort study from Emilia-Romagna (Italy). Cases of EOS registered (from 2009 to 2012) in all gestational age neonates were reviewed. Results: Live births (LB) numbered 146 682. Ninety neonates had EOS and 12 died (incidence rates of 0.61 and 0.08/1000 LB, respectively). EOS and mortality were the highest among neonates with a birth weight n = 27, 0.18/1000 LB) and Escherichia coli (n = 19, 0.13/1000 LB). Most infants affected by E. coli EOS were born preterm (n = 13), had complications (n = 4) or died (n = 7). Among 90 isolates tested, only 3 were resistant to both first line empirical antibiotics. Multivariate logistic regression analysis showed that low gestational age, caesarean section and low platelet count at presentation were significantly associated with death or brain lesions (area under ROC curve = 0.939, H-L = 0.944, sensitivity 76.0%, specificity 90.7%). Conclusions: GBS slightly exceeds E. coli as a cause of EOS. However, E. coli is the prominent cause of death, complications and in most cases affects preterm neonates. Empirical antimicrobial therapy of EOS seems appropriate.

Published
2015

42. Current Knowledge on Endocrine Disrupting Chemicals (EDCs) from Animal Biology to Humans, from Pregnancy to Adulthood: Highlights from a National Italian Meeting

Author

Street, Maria, primary, Angelini, Sabrina, additional, Bernasconi, Sergio, additional, Burgio, Ernesto, additional, Cassio, Alessandra, additional, Catellani, Cecilia, additional, Cirillo, Francesca, additional, Deodati, Annalisa, additional, Fabbrizi, Enrica, additional, Fanos, Vassilios, additional, Gargano, Giancarlo, additional, Grossi, Enzo, additional, Iughetti, Lorenzo, additional, Lazzeroni, Pietro, additional, Mantovani, Alberto, additional, Migliore, Lucia, additional, Palanza, Paola, additional, Panzica, Giancarlo, additional, Papini, Anna, additional, Parmigiani, Stefano, additional, Predieri, Barbara, additional, Sartori, Chiara, additional, Tridenti, Gabriele, additional, and Amarri, Sergio, additional

Published
2018
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43. Van Maldergem syndrome and Hennekam syndrome: Further delineation of allelic phenotypes

Author

Ivanovski, Ivan, primary, Akbaroghli, Susan, additional, Pollazzon, Marzia, additional, Gelmini, Chiara, additional, Caraffi, Stefano Giuseppe, additional, Mansouri, Mahboubeh, additional, Chavoshzadeh, Zahra, additional, Rosato, Simonetta, additional, Polizzi, Valeria, additional, Gargano, Giancarlo, additional, Alders, Marielle, additional, Garavelli, Livia, additional, and Hennekam, Raoul C., additional

Published
2018
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44. Admission Hypothermia in Very Preterm Infants and Neonatal Mortality and Morbidity

Author

Wilson, Emilija, Norman, Mikael, Maier, Rolf F., Misselwitz, Bjoern, Howell, Elizabeth A., Zeitlin, Jennifer, Bonamy, Anna Karin, Van Reempts, Patrick, Martens, Evelyne, Martens, Guy, Pryds, Ole, Boerch, Klaus, Hasselager, Asbjoern, Huusom, Lene, Weber, Tom, Toome, Liis, Varendi, Heili, Truffert, Patrick, Jarreau, Pierre Henri, Ancel, Pierre Yves, Blondel, Beatrice, Burguet, Antoine, Schmidt, Stephan, Gortner, Ludwig, Cuttini, Marina, Croci, Ileana, Baronciani, Dante, Gargano, Giancarlo, Carnielli, Virgilio, Di Lallo, Domenico, Agostino, Rocco, Franco, Francesco, Koopman-Esseboom, Corine, Nijman, Joppe, van Heijst, Arno, Gadzinowski, Janusz, Mazela, Jan, Graça, Luis M., Ceu Machado, Maria, Carapato, Rui, Barros, Henrique, Rodrigues, Carina, Rodrigues, Teresa, Draper, Elizabeth, Boyle, Elaine M., Manktelow, Brad, Milligan, David W A, and Fenton, Alan

Subjects
Male, medicine.medical_specialty, Pediatrics, very preterm birth, Observational Study, Hypothermia, Infant, Premature, Diseases, Body Temperature, 03 medical and health sciences, Patient Admission, 0302 clinical medicine, Risk Factors, Intensive Care Units, Neonatal, 030225 pediatrics, Intensive care, Epidemiology, neonatal intensive care, medicine, Journal Article, Humans, Very Preterm Birth, Hospital Mortality, Prospective Studies, 030212 general & internal medicine, Pediatrics, Perinatology, and Child Health, business.industry, Incidence, Infant, Newborn, medicine.disease, Perinatology, Europe, and Child Health, Postnatal age, Bronchopulmonary dysplasia, Pediatrics, Perinatology and Child Health, Cohort, Necrotizing enterocolitis, Linear Models, Female, epidemiology, business, Infant, Premature, Follow-Up Studies, Cohort study
Abstract

Objective To investigate the association between body temperature at admission to neonatal intensive care and in-hospital mortality in very preterm infants, stratified by postnatal age of death. Moreover, we assessed the association between admission temperature and neonatal morbidity. Study design In this cohort study from 19 regions in 11 European countries, we measured body temperature at admission for infants admitted for neonatal care after very preterm birth (

Published
2016

45. Exposure to Gastric Acid Inhibitors Increases the Risk of Infection in Preterm Very Low Birth Weight Infants but Concomitant Administration of Lactoferrin Counteracts This Effect

Author

Manzoni, Paolo, primary, García Sánchez, Ruben, additional, Meyer, Michael, additional, Stolfi, Ilaria, additional, Pugni, Lorenza, additional, Messner, Hubert, additional, Cattani, Silvia, additional, Betta, Pasqua Maria, additional, Memo, Luigi, additional, Decembrino, Lidia, additional, Bollani, Lina, additional, Rinaldi, Matteo, additional, Fioretti, Maria, additional, Quercia, Michele, additional, Maule, Milena, additional, Tavella, Elena, additional, Mussa, Alessandro, additional, Tzialla, Chryssoula, additional, Laforgia, Nicola, additional, Mosca, Fabio, additional, Magaldi, Rosario, additional, Mostert, Michael, additional, Farina, Daniele, additional, Di Comite, Amelia, additional, Borghesi, Alessandro, additional, Agriesti, Giovanni, additional, Arisio, Riccardo, additional, Franco, Caterina, additional, Guardione, Roberta, additional, Boano, Elena, additional, Catarinella, Alessia, additional, Romano, Cristina, additional, Monetti, Cesare, additional, Sala, Ugo, additional, Carbonara, Caterina, additional, Mastretta, Emmanuele, additional, Del Sordo, Paola, additional, Priolo, Claudio, additional, Galletto, Paolo, additional, Campagnoli, Francesca, additional, Vivalda, Mauro, additional, Bonfante, Giuseppina, additional, Gomirato, Giovanna, additional, Montin, Davide, additional, Camilla, Roberta, additional, Messina, Alessandro, additional, Pieretto, Marta, additional, Cipolla, Domenico, additional, Giuffrè, Mario, additional, Corsello, Giovanni, additional, Natale, Fabio, additional, Vetrano, Gennaro, additional, Tridapalli, Elisabetta, additional, Faldella, Giacomo, additional, Grazia Capretti, Maria, additional, Paolillo, PierMichele, additional, Picone, Simonetta, additional, Lacerenza, Serafina, additional, Gargano, Giancarlo, additional, Magnani, Cristiana, additional, Sergio Saia, Onofrio, additional, and Della Casa, Elena, additional

Published
2018
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46. Association of maternal hypertension and chorioamnionitis with preterm outcomes

Author

Gagliardi, Luigi, Rusconi, Franca, Bellù, Roberto, Zanini, Rinaldo, Mirri, Gianpaolo, Condò, Manuela, Turoli, Daniela, Vanzati, Mara, Mosca, Fabio, De Nisi, Giuseppe, Polacco, Paola, Villa, Elena, Barbarini, Mario, Fasolato, Valeria, Franco, Caterina, Contiero, Raffaella, Ellero, Serena, Cattarossi, Luigi, Abbiati, Laura, Borroni, Cesarina, Prandi, Giovanna, Fabris, Claudio, Vielmi, Francesca, Borgione, Silvia, Agosti, Massimo, Tandoi, Francesco, Guidali, Rosanna, De Curtis, Mario, Tozzi, Claudio, Lucchini, Renato, Battaglioli, Marina, Lista, Gian Luca, Introvini, Paola, Ferrari, Fabrizio, Gallo, Claudio, Bellante, Elvira, Bottura, Chiara, Zeringyte, Aurelija, Pasquali, Francesca, Boccacci, Simona, Latini, Giuseppe, Giannuzzi, Raffaella, Martinelli, Stefano, Brunelli, Alberto, Di Nunzio, Maria Lucia, Vendemmiati, Antonio, Carli, Giovanna, Bordigato, Michela Alfiero, Filippone, Marco, Meneghesso, Davide, Romeo, Nicola, Mammoliti, Palma, Mastretta, Emanuele, Barberis, Laura, Farina, Daniele, Gancia, Gianpaolo, Dalmazzo, Cristina, Napolitano, Marcello, Messina, Francesco, Villa Betania, Napoli, Magaldi, Rosario, Rinaldi, Matteo, Litta, Rosangela, Lago, Paola, Zanardo, Vincenzo, Chiandetti, Lino, Visentin, Stefano, Presta, Giuseppe, Cella, Davide, Poggiani, Carlo, Ferrari, Daniela, Parati, Sara, Lombardo, Francesco, Grigorio, Rosetta, Barera, Graziano, Bove, Maddalena, Poloniato, Antonella, Burgio, Giampiero, Sala, Elena, Barberi, Ignazio, Tiralongo, Venera, Arco, Alessandro, Mazzeo, Danila, Dani, Carlo, Pratesi, Simone, Mignatti, Valeria, Ancora, Gina, Faldella, Giacomo, Grandi, Sara, Locatelli, Chiara, Stronati, Mauro, Perotti, Gianfranco, Chirico, Gaetano, Migliori, Claudio, De Marini, Sergio, Forleo, Vincenzo, Paludetto, Roberto, Capasso, Letizia, Mansi, Giuseppina, Raimondi, Francesco, Bona, Gianni, Stucchi, Ilaria, Savastio, Silvia, Ferrero, Federica, Parola, Andrea, Padovani, Ezio Maria, Viviani, Elena, Pecoraro, Laura, Agostino, Rocco, Gizzi, Camilla, Massenzi, Luca, Messner, Hubert, Staffler, Alex, Salvia, Gennaro, Esposito, Luigi, Forziati, Vincenzo, Latorre, Giuseppe, Sandri, Fabrizio, Alati, Stefania, Demarca, Fabrizio, Lombardi, Oreste, Costabile, Carmine Deni, Scarpelli, Gianfranco, Cavalli, Claudio, Volante, Enrico, Moretti, Sabrina, Ganguzza, Olga, Spinella, Bartolomeo, Haass, Cristina, Scapillati, Eleonora, Consigli, Chiara, Gatta, Alberto, Quitadamo, Pasqua, Boldrini, Antonio, Vuerich, Marco, Sigali, Emilio, Fiorini, Patrizio, Petrucci, Letizia, Moroni, Marco, Meyer, Firenze, Bragetti, Patrizia, Casucci, Paola, Minelli, Liliana, Mezzetti, Daniele, Orfeo, Luigi, De Luca, Maria Gabriella, Laforgia, Nicola, Grassi, Alessandro, Dotta, Andrea, Savignoni, Ferdinando, Bagnoli, Franco, De Felice, Claudio, Badii, Silvia, Biasini, Augusto, Belluzzi, Antonio, Stella, Marcello, Romagnoli, Costantino, Zecca, Enrico, Barone, Giovanni, Colleselli, Paolo, Vecchiato, Luca, Nicolussi, Silvia, Giliberti, Paolo, Chello, Giovanni, Rojo, Silvana, De Vivo, Massimiliano, Giovanettoni, Chiara, Colnaghi, Clelia A., Manfredini, Valeria, Verucci, Elena, Placidi, Giulia, Belloni, Cesare, Carrera, Giuseppe, Zambetti, Chiara, Biban, Paolo, Serra, Alessandra, Sacco, Francesco, Vetrano, Gennaro, Furcolo, Giuseppe, Pasquariello, Brigida, Falco, Luigi, Ausanio, Gaetano, Bernardo, Italo, Capasso, Antonella, Marchesano, Giuseppe, Nosari, Norberto, Sarnelli, Paola, Ciraci, Giovanni, Merazzi, Daniele, Gazzolo, Diego, Temperini, Francesca, Sabatini, Miriam, Colivicchi, Micaela, Del Vecchio, Antonio, Tarantino, Marzia, Gargano, Giancarlo, Pedori, Simona, Bellettato, Massimo, Pesavento, Roberta, Cesaro, Alessandra, Scollo, Massimo, Mondello, Isabella, Pugliese, Aniello, Iervolino, Claudio, Corsello, Giovanni, Giuffré, Mario, Betta, Pasqua, Romeo, Mario Giuseppe, Saporito, Alessandro, Leone, Maria Grazia, Rodonò, Alessandro, Franceschi, Alessia, Risso, Francesco M., Carpentieri, Mauro, Vecchiano, Teresa, Cigliano, Maria Pia, Paolillo, Piermichele, Picone, Simonetta, Marra, Antonio, Rossetti, Gessica, Testa, Tiziana, Del Cuore, Fernando, Crescenzi, Francesco, Poloni, Gianna, Russo, Maria Chiara, Nigro, Francesco, Tina, Gabriella Lucia, Brindisino, Patrizia, Gurrado, Raffaele, Felice, Maurizio, Formica, Isabella, Gagliardi, L, Rusconi, F, Bellu, R, Zanini, R, Corsello, G, Giuffre, M, Italian Neonatal Network, Luigi Gagliardi, Franca Rusconi, Roberto Bellù, Rinaldo Zanini, the Italian Neonatal Network [.., Gina Ancora, Giacomo Faldella, Sara Grandi, Chiara Locatelli, ]., Gagliardi, Luigi, Rusconi, Franca, Bellù, Roberto, Zanini, Rinaldo, Mirri, Gianpaolo, Condò, Manuela, Turoli, Daniela, Vanzati, Mara, Mosca, Fabio, De Nisi, Giuseppe, Polacco, Paola, Villa, Elena, Barbarini, Mario, Fasolato, Valeria, Franco, Caterina, Contiero, Raffaella, Ellero, Serena, Cattarossi, Luigi, Abbiati, Laura, Borroni, Cesarina, Prandi, Giovanna, Fabris, Claudio, Vielmi, Francesca, Borgione, Silvia, Agosti, Massimo, Tandoi, Francesco, Guidali, Rosanna, De Curtis, Mario, Tozzi, Claudio, Lucchini, Renato, Battaglioli, Marina, Lista, Gian Luca, Introvini, Paola, Ferrari, Fabrizio, Gallo, Claudio, Bellante, Elvira, Bottura, Chiara, Zeringyte, Aurelija, Pasquali, Francesca, Boccacci, Simona, Latini, Giuseppe, Giannuzzi, Raffaella, Martinelli, Stefano, Brunelli, Alberto, Di Nunzio, Maria Lucia, Vendemmiati, Antonio, Carli, Giovanna, Bordigato, Michela Alfiero, Filippone, Marco, Meneghesso, Davide, Romeo, Nicola, Mammoliti, Palma, Mastretta, Emanuele, Barberis, Laura, Farina, Daniele, Gancia, Gianpaolo, Dalmazzo, Cristina, Napolitano, Marcello, Messina, Francesco, Villa Betania, Napoli, Magaldi, Rosario, Rinaldi, Matteo, Litta, Rosangela, Lago, Paola, Zanardo, Vincenzo, Chiandetti, Lino, Visentin, Stefano, Presta, Giuseppe, Cella, Davide, Poggiani, Carlo, Ferrari, Daniela, Parati, Sara, Lombardo, Francesco, Grigorio, Rosetta, Barera, Graziano, Bove, Maddalena, Poloniato, Antonella, Burgio, Giampiero, Sala, Elena, Barberi, Ignazio, Tiralongo, Venera, Arco, Alessandro, Mazzeo, Danila, Dani, Carlo, Pratesi, Simone, Mignatti, Valeria, Ancora, Gina, Faldella, Giacomo, Grandi, Sara, Locatelli, Chiara, Stronati, Mauro, Perotti, Gianfranco, Chirico, Gaetano, Migliori, Claudio, De Marini, Sergio, Forleo, Vincenzo, Paludetto, Roberto, Capasso, Letizia, Mansi, Giuseppina, Raimondi, Francesco, Bona, Gianni, Stucchi, Ilaria, Savastio, Silvia, Ferrero, Federica, Parola, Andrea, Padovani, Ezio Maria, Viviani, Elena, Pecoraro, Laura, Agostino, Rocco, Gizzi, Camilla, Massenzi, Luca, Messner, Hubert, Staffler, Alex, Salvia, Gennaro, Esposito, Luigi, Forziati, Vincenzo, Latorre, Giuseppe, Sandri, Fabrizio, Alati, Stefania, Demarca, Fabrizio, Lombardi, Oreste, Costabile, Carmine Deni, Scarpelli, Gianfranco, Cavalli, Claudio, Volante, Enrico, Moretti, Sabrina, Ganguzza, Olga, Spinella, Bartolomeo, Haass, Cristina, Scapillati, Eleonora, Consigli, Chiara, Gatta, Alberto, Quitadamo, Pasqua, Boldrini, Antonio, Vuerich, Marco, Sigali, Emilio, Fiorini, Patrizio, Petrucci, Letizia, Moroni, Marco, Meyer, Firenze, Bragetti, Patrizia, Casucci, Paola, Minelli, Liliana, Mezzetti, Daniele, Orfeo, Luigi, De Luca, Maria Gabriella, Laforgia, Nicola, Grassi, Alessandro, Dotta, Andrea, Savignoni, Ferdinando, Bagnoli, Franco, De Felice, Claudio, Badii, Silvia, Biasini, Augusto, Belluzzi, Antonio, Stella, Marcello, Romagnoli, Costantino, Zecca, Enrico, Barone, Giovanni, Colleselli, Paolo, Vecchiato, Luca, Nicolussi, Silvia, Giliberti, Paolo, Chello, Giovanni, Rojo, Silvana, De Vivo, Massimiliano, Giovanettoni, Chiara, Colnaghi, Clelia A., Manfredini, Valeria, Verucci, Elena, Placidi, Giulia, Belloni, Cesare, Carrera, Giuseppe, Zambetti, Chiara, Biban, Paolo, Serra, Alessandra, Sacco, Francesco, Vetrano, Gennaro, Furcolo, Giuseppe, Pasquariello, Brigida, Falco, Luigi, Ausanio, Gaetano, Bernardo, Italo, Capasso, Antonella, Marchesano, Giuseppe, Nosari, Norberto, Sarnelli, Paola, Ciraci, Giovanni, Merazzi, Daniele, Gazzolo, Diego, Temperini, Francesca, Sabatini, Miriam, Colivicchi, Micaela, Del Vecchio, Antonio, Tarantino, Marzia, Gargano, Giancarlo, Pedori, Simona, Bellettato, Massimo, Pesavento, Roberta, Cesaro, Alessandra, Scollo, Massimo, Mondello, Isabella, Pugliese, Aniello, Iervolino, Claudio, Corsello, Giovanni, Giuffré, Mario, Betta, Pasqua, Romeo, Mario Giuseppe, Saporito, Alessandro, Leone, Maria Grazia, Rodonò, Alessandro, Franceschi, Alessia, Risso, Francesco M., Carpentieri, Mauro, Vecchiano, Teresa, Cigliano, Maria Pia, Paolillo, Piermichele, Picone, Simonetta, Marra, Antonio, Rossetti, Gessica, Testa, Tiziana, Del Cuore, Fernando, Crescenzi, Francesco, Poloni, Gianna, Russo, Maria Chiara, Nigro, Francesco, Tina, Gabriella Lucia, Brindisino, Patrizia, Gurrado, Raffaele, Felice, Maurizio, and Formica, Isabella

Subjects
Male, Pediatrics, Logistic models, Mortality, Outcomes, Pregnancy complications, Preterm infants, Risks, Female, Gestational Age, Humans, Infant, Newborn, Infant, Premature, Diseases, Pregnancy, Pregnancy Outcome, Prospective Studies, Chorioamnionitis, Hypertension, Pregnancy-Induced, Pediatrics, Perinatology and Child Health, Medicine (all), Arts and Humanities (miscellaneous), Diseases, outcomes, Maternal hypertension, risk, Obstetrics, pregnancy complications, Gestational age, Retinopathy of prematurity, Perinatology and Child Health, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Logistic models, Mortality, Outcomes, Pregnancy complications, Preterm infants, Risks, Necrotizing enterocolitis, Hypertension, outcome, Human, medicine.medical_specialty, Pregnancy-Induced, preterm infant, Pregnancy complication, medicine, preterm infants, Premature, logistic model, Chorioamnioniti, business.industry, Infant, Infant, Premature, Disease, Odds ratio, medicine.disease, Newborn, mortality, Prospective Studie, Bronchopulmonary dysplasia, business, logistic models, risks
Abstract

OBJECTIVES: We compared the relative effect of hypertensive disorders of pregnancy and chorioamnionitis on adverse neonatal outcomes in very preterm neonates, and studied whether gestational age (GA) modulates these effects. METHODS: A cohort of neonates 23 to 30 weeks' GA, born in 2008 to 2011 in 82 hospitals adhering to the Italian Neonatal Network, was analyzed. Infants born from mothers who had hypertensive disorders (N = 2096) were compared with those born after chorioamnionitis (N = 1510). Statistical analysis employed logistic models, adjusting for GA, hospital, and potential confounders. RESULTS: Overall mortality was higher after hypertension than after chorioamnionitis (odds ratio [OR], 1.39; 95% confidence interval [CI], 1.08–1.80), but this relationship changed across GA weeks; the OR for hypertension was highest at low GA, whereas from 28 weeks' GA onward, mortality was higher for chorioamnionitis. For other outcomes, the relative risks were constant across GA; infants born after hypertension had an increased risk for bronchopulmonary dysplasia (OR, 2.20; 95% CI, 1.68–2.88) and severe retinopathy of prematurity (OR, 1.48; 95% CI, 1.02–2.15), whereas there was a lower risk for early-onset sepsis (OR, 0.25; 95% CI, 0.19–0.34), severe intraventricular hemorrhage (OR, 0.65; 95% CI, 0.48–0.88), periventricular leukomalacia (OR, 0.70; 95% CI, 0.48–1.01), and surgical necrotizing enterocolitis or gastrointestinal perforation (OR, 0.47; 95% CI, 0.31–0.72). CONCLUSIONS: Mortality and other adverse outcomes in very preterm infants depend on antecedents of preterm birth. Hypertension and chorioamnionitis are associated with different patterns of outcomes; for mortality, the effect changes across GA weeks.

Published
2014

47. Neuroprem: the Neuro-developmental outcome of very low birth weight infants in an Italian region.

Author

Lugli, Licia, Pugliese, Marisa, Plessi, Carlotta, Berardi, Alberto, Guidotti, Isotta, Ancora, Gina, Grandi, Sara, Gargano, Giancarlo, Braibanti, Silvia, Sandri, Fabrizio, Soffritti, Silvia, Ballardini, Elisa, Arena, Vittoria, Stella, Marcello, Perrone, Serafina, Moretti, Sabrina, Rizzo, Vittoria, Ferrari, Fabrizio, Picciolini, Odoardo, and Bellù, Roberto

Subjects
LOW birth weight, CEREBRAL palsy, DEVELOPMENTAL disabilities, FUNCTIONAL assessment, LONGITUDINAL method, NEONATAL intensive care, RISK assessment, NEONATAL intensive care units, DESCRIPTIVE statistics, DISEASE risk factors
Abstract

Introduction: The survival of preterm babies has increased worldwide, but the risk of neuro-developmental disabilities remains high, which is of concern to both the public and professionals. The early identification of children at risk of neuro-developmental disabilities may increase access to intervention, potentially influencing the outcome. Aims: Neuroprem is an area-based prospective cohort study on the neuro-developmental outcome of very low birth weight (VLBW) infants that aims to define severe functional disability at 2 years of age. Methods: Surviving VLBW infants from an Italian network of 7 neonatal intensive care units (NICUs) were assessed for 24 months through the Griffiths Mental Developmental Scales (GMDS-R) or the Bayley Scales of Infant and Toddler Development (BSDI III) and neuro-functional evaluation according to the International Classification of Disability and Health (ICF-CY). The primary outcome measure was severe functional disability at 2 years of age, defined as cerebral palsy, a BSDI III cognitive composite score < 2 standard deviation (SD) or a GMDS-R global quotients score < 2 SD, bilateral blindness or deafness. Results: Among 211 surviving VLBW infants, 153 completed follow-up at 24 months (72.5%). Thirteen patients (8.5%) developed a severe functional disability, of whom 7 presented with cerebral palsy (overall rate of 4.5%). Patients with cerebral palsy were all classified with ICF-CY scores of 3 or 4. BSDI III composite scores and GMDS-R subscales were significantly correlated with ICF-CY scores (p < 0.01). Conclusion: Neuroprem represents an Italian network of NICUs aiming to work together to ensure preterm neuro-developmental assessment. This study updates information on VLBW outcomes in an Italian region, showing a rate of cerebral palsy and major developmental disabilities in line with or even lower than those of similar international studies. Therefore, Neuroprem provides encouraging data on VLBW neurological outcomes and supports the implementation of a preterm follow-up programme from a national network perspective. [ABSTRACT FROM AUTHOR]

Published
2020
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48. Group B Streptococcus early-onset disease and observation of well-appearing newborns.

Author

Berardi, Alberto, Spada, Caterina, Reggiani, Maria Letizia Bacchi, Creti, Roberta, Baroni, Lorenza, Capretti, Maria Grazia, Ciccia, Matilde, Fiorini, Valentina, Gambini, Lucia, Gargano, Giancarlo, Papa, Irene, Piccinini, Giancarlo, Rizzo, Vittoria, Sandri, Fabrizio, Lucaccioni, Laura, and null, null

Subjects
STREPTOCOCCUS, STREPTOCOCCUS agalactiae, DEVELOPMENTAL biology, ANTIBIOTIC prophylaxis, BODY fluids, INFANTS
Abstract

Background: International guidelines lack a substantial consensus regarding management of asymptomatic full-term and late preterm neonates at risk for early-onset disease (EOS). Large cohorts of newborns are suitable to increase the understanding of the safety and efficacy of a given strategy. Methods: This is a prospective, area-based, cohort study involving regional birth facilities of Emilia-Romagna (Italy). We compared cases of EOS (at or above 35 weeks' gestation) registered in 2003–2009 (baseline period: 266,646 LBs) and in 2010–2016, after introduction of a new strategy (serial physical examinations, SPEs) for managing asymptomatic neonates at risk for EOS (intervention period: 265,508 LBs). Results: There were 108 cases of EOS (baseline period, n = 60; intervention period, n = 48). Twenty-two (20.4%) remained asymptomatic through the first 72 hours of life, whereas 86 (79.6%) developed symptoms, in most cases (52/86, 60.5%) at birth or within 6 hours. The median age at presentation was significantly earlier in the intrapartum antibiotic prophylaxis (IAP)-exposed than in the IAP-unexposed neonates (0 hours, IQR 0.0000–0.0000 vs 6 hours, IQR 0.0000–15.0000, p<0.001). High number of neonates (n = 531) asymptomatic at birth, exposed to intrapartum fever, should be treated empirically for each newborn who subsequently develops sepsis. IAP exposed neonates increased (12% vs 33%, p = 0.01), age at presentation decreased (median 6 vs 1 hours, p = 0.01), whereas meningitis, mechanical ventilation and mortality did not change in baseline vs intervention period. After implementing the SPEs, no cases had adverse outcomes due to the strategy, and no cases developed severe disease after 6 hours of life. Conclusions: Infants with EOS exposed to IAP developed symptoms at birth in almost all cases, and those who appeared well at birth had a very low chance of having EOS. The risk of EOS in neonates (asymptomatic at birth) exposed to intrapartum fever was low. Although definite conclusions on causation are lacking, our data support SPEs of asymptomatic newborns at risk for EOS. SPEs seems a safe and effective alternative to laboratory screening and empirical antibiotic therapy. [ABSTRACT FROM AUTHOR]

Published
2019
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49. Association of short antenatal corticosteroid administration-to-birth intervals with survival and morbidity among very preterm infants results from the EPICE cohort

Author

UMC Utrecht, MS Neonatologie, Arts-assistenten Kinderen, Norman, Mikael, Piedvache, Aurelie, Børch, Klaus, Huusom, Lene Drasbek, Bonamy, Anna Karin Edstedt, Howell, Elizabeth A., Jarreau, Pierre Henri, Maier, Rolf F., Pryds, Ole, Toome, Liis, Varendi, Heili, Weber, Tom, Wilson, Emilija, van Heijst, Arno, Cuttini, Marina, Mazela, Jan, Barros, Henrique, Van Reempts, Patrick, Draper, Elizabeth S., Zeitlin, Jennifer, Martens, Evelyne, Martens, Guy, Hasselager, Asbjoern, Ancel, Pierre Yves, Blondel, Béatrice, Bonet, Mercedes, Burguet, Antoine, Truffert, Patrick, Misselwitz, Bjoern, Schmidt, Stephan, Gortner, Ludvig, Baronciani, Dante, Gargano, Giancarlo, Agostino, Rocco, DiLallo, Domenico, Franco, Francesco, Carnielli, Virgilio, Croci, Ileana, Koopman-Esseboom, Corrine, Nijman, Joppe, Gadzinowski, Janusz, Graça, Luís Mendes, Do Céu Machado, Maria, Rodrigues, Carina, Ribeiro-Rodrigues, Teresa, Boyle, Elaine M., Manktelow, Brad N., Fenton, Alan C., Effective Perinatal Intensive Care in Europe (EPICE) Research Group, UMC Utrecht, MS Neonatologie, Arts-assistenten Kinderen, Norman, Mikael, Piedvache, Aurelie, Børch, Klaus, Huusom, Lene Drasbek, Bonamy, Anna Karin Edstedt, Howell, Elizabeth A., Jarreau, Pierre Henri, Maier, Rolf F., Pryds, Ole, Toome, Liis, Varendi, Heili, Weber, Tom, Wilson, Emilija, van Heijst, Arno, Cuttini, Marina, Mazela, Jan, Barros, Henrique, Van Reempts, Patrick, Draper, Elizabeth S., Zeitlin, Jennifer, Martens, Evelyne, Martens, Guy, Hasselager, Asbjoern, Ancel, Pierre Yves, Blondel, Béatrice, Bonet, Mercedes, Burguet, Antoine, Truffert, Patrick, Misselwitz, Bjoern, Schmidt, Stephan, Gortner, Ludvig, Baronciani, Dante, Gargano, Giancarlo, Agostino, Rocco, DiLallo, Domenico, Franco, Francesco, Carnielli, Virgilio, Croci, Ileana, Koopman-Esseboom, Corrine, Nijman, Joppe, Gadzinowski, Janusz, Graça, Luís Mendes, Do Céu Machado, Maria, Rodrigues, Carina, Ribeiro-Rodrigues, Teresa, Boyle, Elaine M., Manktelow, Brad N., Fenton, Alan C., and Effective Perinatal Intensive Care in Europe (EPICE) Research Group

Published
2017

50. Admission Hypothermia in Very Preterm Infants and Neonatal Mortality and Morbidity

Author

MS Neonatologie, Brain, Arts-assistenten Kinderen, Wilson, Emilija, Norman, Mikael, Maier, Rolf F., Misselwitz, Bjoern, Howell, Elizabeth A., Zeitlin, Jennifer, Bonamy, Anna Karin, Van Reempts, Patrick, Martens, Evelyne, Martens, Guy, Pryds, Ole, Boerch, Klaus, Hasselager, Asbjoern, Huusom, Lene, Weber, Tom, Toome, Liis, Varendi, Heili, Truffert, Patrick, Jarreau, Pierre Henri, Ancel, Pierre Yves, Blondel, Beatrice, Burguet, Antoine, Schmidt, Stephan, Gortner, Ludwig, Cuttini, Marina, Croci, Ileana, Baronciani, Dante, Gargano, Giancarlo, Carnielli, Virgilio, Di Lallo, Domenico, Agostino, Rocco, Franco, Francesco, Koopman-Esseboom, Corine, Nijman, Joppe, van Heijst, Arno, Gadzinowski, Janusz, Mazela, Jan, Graça, Luis M., Ceu Machado, Maria, Carapato, Rui, Barros, Henrique, Rodrigues, Carina, Rodrigues, Teresa, Draper, Elizabeth, Boyle, Elaine M., Manktelow, Brad, Milligan, David W A, Fenton, Alan, MS Neonatologie, Brain, Arts-assistenten Kinderen, Wilson, Emilija, Norman, Mikael, Maier, Rolf F., Misselwitz, Bjoern, Howell, Elizabeth A., Zeitlin, Jennifer, Bonamy, Anna Karin, Van Reempts, Patrick, Martens, Evelyne, Martens, Guy, Pryds, Ole, Boerch, Klaus, Hasselager, Asbjoern, Huusom, Lene, Weber, Tom, Toome, Liis, Varendi, Heili, Truffert, Patrick, Jarreau, Pierre Henri, Ancel, Pierre Yves, Blondel, Beatrice, Burguet, Antoine, Schmidt, Stephan, Gortner, Ludwig, Cuttini, Marina, Croci, Ileana, Baronciani, Dante, Gargano, Giancarlo, Carnielli, Virgilio, Di Lallo, Domenico, Agostino, Rocco, Franco, Francesco, Koopman-Esseboom, Corine, Nijman, Joppe, van Heijst, Arno, Gadzinowski, Janusz, Mazela, Jan, Graça, Luis M., Ceu Machado, Maria, Carapato, Rui, Barros, Henrique, Rodrigues, Carina, Rodrigues, Teresa, Draper, Elizabeth, Boyle, Elaine M., Manktelow, Brad, Milligan, David W A, and Fenton, Alan

Published
2016

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