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13 results on '"Garg, Madhuri"'

1. CXCL9 Links Skin Inflammation and Fibrosis through CXCR3-Dependent Upregulation of Col1a1 in Fibroblasts

Author

Richmond, Jillian M., Patel, Dhrumil, Watanabe, Tomoya, Chen, Henry W., Martyanov, Viktor, Werner, Giffin, Garg, Madhuri, Haddadi, Nazgol-Sadat, Refat, Maggi Ahmed, Mahmoud, Bassel H., Wong, Lance D., Dresser, Karen, Deng, April, Zhu, Jane L., McAlpine, William, Hosler, Gregory A., Feghali-Bostwick, Carol A., Whitfield, Michael L., Harris, John E., Torok, Kathryn S., and Jacobe, Heidi T.

Published
2023
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3. CXCL9 links skin inflammation and fibrosis via CXCR3-dependent upregulation of collagen 1a1 in fibroblasts

Author

Richmond, Jillian M., primary, Patel, Dhrumil, additional, Watanabe, Tomoya, additional, Chen, Henry W., additional, Martyanov, Viktor, additional, Werner, Giffin, additional, Garg, Madhuri, additional, Haddadi, Nazgol-Sadat, additional, Refat, Maggi Ahmed, additional, Mahmoud, Bassel H., additional, Wong, Lance D., additional, Dresser, Karen, additional, Deng, April, additional, Zhu, Jane L., additional, McAlpine, William, additional, Hosler, Gregory A., additional, Feghali-Bostwick, Carol A., additional, Whitfield, Michael L., additional, Harris, John E., additional, Torok, Kathryn S., additional, and Jacobe, Heidi T., additional

Published
2023
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7. Isolated myocardial abscess cavity: An incidental finding on intraoperative transesophageal echocardiography.

Author

Garg, Mukesh, Bhargava, Jyotsna, Garg, Madhuri, and Garg, Sukhdev

Subjects
INFECTIVE endocarditis, TRANSESOPHAGEAL echocardiography, HEART conduction system, ABSCESSES, AORTIC valve, CARDIAC surgery
Abstract

Myocardial abscess is a suppurative infection of myocardium, endocardium, native or prosthetic valves, perivalvular structures and cardiac conduction system. It develops in about 20% of patients with infective endocarditis. Due to avascular and fibrous structures, valvular regions are commonly involved. More precisely, aortic valve (AV) rings area; native or prosthetic valve is usually affected. Occurrence of myocardial abscess within free wall of the left ventricle (LV) without any evidence of infective endocarditis is a rare phenomenon; and infrequently reported in medical literature. We report a case of myocardial abscess cavity within the anterior wall of the LV, in a patient who underwent open heart surgery for severe AV stenosis. This was an incidental intraoperative transesophageal echocardiography (TEE) finding without any other evidence of infective endocarditis. The stenotic AV was replaced, along with surgical drainage and closure of the cavity. Postoperatively, patient was managed on empirical antibiotics according to infective endocarditis guidelines. [ABSTRACT FROM AUTHOR]

Published
2021
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9. Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo

Author

Richmond, Jillian M., primary, Strassner, James P., additional, Zapata, Lucio, additional, Garg, Madhuri, additional, Riding, Rebecca L., additional, Refat, Maggi A., additional, Fan, Xueli, additional, Azzolino, Vincent, additional, Tovar-Garza, Andrea, additional, Tsurushita, Naoya, additional, Pandya, Amit G., additional, Tso, J. Yun, additional, and Harris, John E., additional

Published
2018
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10. Treatment with CD122 antibody durably reverses autoimmune skin disease in a mouse model of vitiligo

Author

Richmond, Jillian M, primary, Zapata, Lucio, additional, Garg, Madhuri, additional, Strassner, James, additional, Rashighi, Mehdi, additional, Riding, Rebecca, additional, Ahmed, Maggi, additional, Essien, Kingsley, additional, Pell, Lila, additional, Agarwal, Priti, additional, Tsurushita, Naoya, additional, Tso, J Yun, additional, and Harris, John, additional

Published
2017
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11. CXCL9 Links Skin Inflammation and Fibrosis through CXCR3-Dependent Upregulation of Col1a1in Fibroblasts

Author

Richmond, Jillian M., Patel, Dhrumil, Watanabe, Tomoya, Chen, Henry W., Martyanov, Viktor, Werner, Giffin, Garg, Madhuri, Haddadi, Nazgol-Sadat, Refat, Maggi Ahmed, Mahmoud, Bassel H., Wong, Lance D., Dresser, Karen, Deng, April, Zhu, Jane L., McAlpine, William, Hosler, Gregory A., Feghali-Bostwick, Carol A., Whitfield, Michael L., Harris, John E., Torok, Kathryn S., and Jacobe, Heidi T.

Abstract

Morphea is characterized by initial inflammation followed by fibrosis of the skin and soft tissue. Despite its substantial morbidity, the pathogenesis of morphea is poorly studied. Previous work showed that CXCR3 ligands CXCL9 and CXCL10 are highly upregulated in the sera and lesional skin of patients with morphea. We found that an early inflammatory subcutaneous bleomycin mouse model of dermal fibrosis mirrors the clinical, histological, and immune dysregulation observed in human morphea. We used this model to examine the role of the CXCR3 chemokine axis in the pathogenesis of cutaneous fibrosis. Using the REX3 (Reporting the Expression of CXCR3 ligands) mice, we characterized which cells produce CXCR3 ligands over time. We found that fibroblasts contribute the bulk of CXCL9-RFP and CXCL10-BFP by percentage, whereas macrophages produce high amounts on a per-cell basis. To determine whether these chemokines are mechanistically involved in pathogenesis, we treated Cxcl9-, Cxcl10-, or Cxcr3-deficient mice with bleomycin and found that fibrosis is dependent on CXCL9 and CXCR3. Addition of recombinant CXCL9 but not CXCL10 to cultured mouse fibroblasts induced Col1a1mRNA expression, indicating that the chemokine itself contributes to fibrosis. Taken together, our studies provide evidence that CXCL9 and its receptor CXCR3 are functionally required for inflammatory fibrosis.

Published
2023
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