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Byline: Sukender. Kumar, Chanchal. Garg, Samander. Kaushik, Harpal. Buttar, Munish. Garg Viral infections are posing a great threat to humanity for the last few years. Among these, Chikungunya which is [...]

Acute myocardial infarction (AMI) results from the intervention of blood supply to the heart, due to this heart cells to die. It is the leading cause of mortality and morbidity in present days. Chest pain is the most common symptom in majority of the patients with AMI. Cardiac markers are released during chest pain. So there is an emerging need to detect for early, specific cardiac markers. Glycogen phosphorylase BB (GPBB) is potential marker of chest pain and myocardial infarction. Objective of the study was to compare the sensitivity and specificity of GPBB and CKMB at 1st hour after of acute myocardial infarction. Blood samples from 80 AMI patients and 50 age and sex matched healthy controls were collected and analyzed for cardiac enzymes CK-MB (by automated analyzer) and GPBB (by ELISA reader). GPBB had released after 1 hour and higher peak value after 3 h of chest pain in AMI patients. The receiver operating characteristic curves was significantly greater for GPBB when compare with CKMB in AMI patients. GPBB is considerably sensitive and specific at the first hour of admission in AMI patients. It is elevated in all of the AMI patients. [ABSTRACT FROM AUTHOR]

Unprincipled use of antibiotics has led to antimicrobial resistance (AMR) against mostly available compounds, and has now become a major cause of concern for the scientific community. However, in the past decade, green synthesized silver nanoparticles (AgNPs) have received greater attention for the development of newer therapies as antimicrobials by virtue of their unique physico- chemical properties. Unlike traditional antibiotics, AgNPs exert their action by acting on multiple mechanisms, which make them potential candidates against AMR. Green synthesis of AgNPs using various medicinal plants has demonstrated a broader spectrum of action against several microbes in a number of attempts. The present paper provides an insight into the scientific studies that have elucidated the positive role of plant extracts/phytochemicals during the green synthesis of AgNPs and their future perspectives. The studies conducted so far seem promising; still, a few factors like the precise mechanism of action of AgNPs, their synergistic interaction with biomolecules, and industrial scalability, need to be explored further till effective drug development using green synthesized AgNPs in healthcare systems against AMR is established., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)