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5. Comparison of Caregiver‐ and Child‐Reported Quality of Life in Children With Sleep‐Disordered Breathing

Author

Yu, Phoebe Kuo, primary, Cook, Kaitlyn, additional, Liu, Jiayan, additional, Amin, Raouf S., additional, Derkay, Craig, additional, Elden, Lisa M., additional, Garetz, Susan L., additional, George, Alisha S., additional, Ibrahim, Sally, additional, Ishman, Stacey L., additional, Kirkham, Erin M., additional, Naqvi, S. Kamal, additional, Radcliffe, Jerilynn, additional, Ross, Kristie R., additional, Shah, Gopi B., additional, Tapia, Ignacio E., additional, Taylor, H. Gerry, additional, Zopf, David A., additional, Redline, Susan, additional, and Baldassari, Cristina M., additional

Published
2022
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8. Neurobehavioral morbidity of pediatric mild sleep-disordered breathing and obstructive sleep apnea

Author

Yu, Phoebe K, primary, Radcliffe, Jerilynn, additional, Gerry Taylor, H, additional, Amin, Raouf S, additional, Baldassari, Cristina M, additional, Boswick, Thomas, additional, Chervin, Ronald D, additional, Elden, Lisa M, additional, Furth, Susan L, additional, Garetz, Susan L, additional, George, Alisha, additional, Ishman, Stacey L, additional, Kirkham, Erin M, additional, Liu, Christopher, additional, Mitchell, Ron B, additional, Kamal Naqvi, S, additional, Rosen, Carol L, additional, Ross, Kristie R, additional, Shah, Jay R, additional, Tapia, Ignacio E, additional, Young, Lisa R, additional, Zopf, David A, additional, Wang, Rui, additional, and Redline, Susan, additional

Published
2022
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10. Comparison of Caregiver‐ and Child‐Reported Quality of Life in Children With Sleep‐Disordered Breathing.

Author

Yu, Phoebe Kuo, Cook, Kaitlyn, Liu, Jiayan, Amin, Raouf S., Derkay, Craig, Elden, Lisa M., Garetz, Susan L., George, Alisha S., Ibrahim, Sally, Ishman, Stacey L., Kirkham, Erin M., Naqvi, S. Kamal, Radcliffe, Jerilynn, Ross, Kristie R., Shah, Gopi B., Tapia, Ignacio E., Taylor, H. Gerry, Zopf, David A., Redline, Susan, and Baldassari, Cristina M.

Abstract

Objective: Caregivers frequently report poor quality of life (QOL) in children with sleep‐disordered breathing (SDB). Our objective is to assess the correlation between caregiver‐ and child‐reported QOL in children with mild SDB and identify factors associated with differences between caregiver and child report. Study Design: Analysis of baseline data from a multi‐institutional randomized trial Setting: Pediatric Adenotonsillectomy Trial for Snoring, where children with mild SDB (obstructive apnea‐hypopnea index <3) were randomized to observation or adenotonsillectomy. Methods: The Pediatric Quality of Life Inventory (PedsQL) assessed baseline global QOL in participating children 5 to 12 years old and their caregivers. Caregiver and child scores were compared. Multivariable regression assessed whether clinical factors were associated with differences between caregiver and child report. Results: PedsQL scores were available for 309 families (mean child age, 7.0 years). The mean caregiver‐reported PedsQL score was higher at 75.2 (indicating better QOL) than the mean child‐reported score of 67.9 (P <.001). The agreement between caregiver and child total PedsQL scores was poor, with intraclass correlation coefficients of 0.03 (95% CI, –0.09 to 0.15) for children 5 to 7 years old and 0.21 (95% CI, 0.03‐0.38) for children 8 to 12 years old. Higher child age and health literacy were associated with closer agreement between caregiver and child report. Conclusion: Caregiver‐ and child‐reported global QOL in children with SDB was weakly correlated, more so for young children. In pediatric SDB, child‐perceived QOL may be poorer than that reported by caregivers. Further research is needed to assess whether similar trends exist for disease‐specific QOL metrics. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Prognosis for Spontaneous Resolution of OSA in Children

Author

Chervin, Ronald D., Ellenberg, Susan S., Hou, Xiaoling, Marcus, Carole L., Garetz, Susan L., Katz, Eliot S., Hodges, Elise K., Mitchell, Ron B., Jones, Dwight T., Arens, Raanan, Amin, Raouf, Redline, Susan, Rosen, Carol L., Katz, Eliot, Ware, Janice, Jones, Dwight, Redline, Susan, Wang, Rui, Mitchell, Ron, Paruthi, Shalini, Snyder, Karen, Marcus, Carole, Thomas, Nina H., Elden, Lisa, Amin, Raouf, Beebe, Dean, Willging, Paul, Arens, Raanan, Muzumdar, Hiren, Harris, Shelby, Rosen, Carol, Taylor, H. Gerry, Sprecher, Robert, Arnold, James, Gozal, David, Chervin, Ronald, Garetz, Susan, Giordani, Bruno, Hoban, Tim, Ellenberg, Susan, Moore, Reneé H., and Lacy, Kim

Published
2015
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12. Supplement to: A randomized trial of adenotonsillectomy for childhood sleep apnea.

Author

Marcus, Carole L., Moore, Reneé H., Rosen, Carol L., Giordani, Bruno, Garetz, Susan L., Taylor, Gerry H., Mitchell, Ron B., Amin, Raouf, Katz, Eliot S., Arens, Raanan, Paruthi, Shalini, Muzumdar, Hiren, Gozal, David, Thomas, Nina Hattiangadi, Ware, Janice, Beebe, Dean, Snyder, Karen, Elden, Lisa, Sprecher, Robert C., Willging, Paul, Jones, Dwight, Bent, John P., Hoban, Timothy, Chervin, Ronald D., Ellenberg, Susan S., and Redline, Susan

Published
2013

15. A Randomized Trial of Adenotonsillectomy for Childhood Sleep Apnea

Author

Marcus, Carole L., Moore, Reneé H., Rosen, Carol L., Giordani, Bruno, Garetz, Susan L., Taylor, H. Gerry, Mitchell, Ron B., Amin, Raouf, Katz, Eliot S., Arens, Raanan, Paruthi, Shalini, Muzumdar, Hiren, Gozal, David, Thomas, Nina Hattiangadi, Ware, Janice, Beebe, Dean, Snyder, Karen, Elden, Lisa, Sprecher, Robert C., Willging, Paul, Jones, Dwight, Bent, John P., Hoban, Timothy, Chervin, Ronald D., Ellenberg, Susan S., and Redline, Susan

Published
2013
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18. Pediatric Adenotonsillectomy Trial for Snoring (PATS): protocol for a randomised controlled trial to evaluate the effect of adenotonsillectomy in treating mild obstructive sleep-disordered breathing

Author

Wang, Rui, primary, Bakker, Jessie P., additional, Chervin, Ronald D., additional, Garetz, Susan L., additional, Hassan, Fauziya, additional, Ishman, Stacey L., additional, Mitchell, Ron B., additional, Morrical, Michael G., additional, Naqvi, Syed K., additional, Radcliffe, Jerilynn, additional, Riggan, Emily I., additional, Rosen, Carol L., additional, Ross, Kristie, additional, Rueschman, Michael, additional, Tapia, Ignacio E., additional, Taylor, H. Gerry, additional, Zopf, David A., additional, and Redline, Susan, additional

Published
2020
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26. Pediatric Adenotonsillectomy Trial for Snoring (PATS): protocol for a randomised controlled trial to evaluate the effect of adenotonsillectomy in treating mild obstructive sleep-disordered breathing.

Author

Rui Wang, Bakker, Jessie P., Chervin, Ronald D., Garetz, Susan L., Hassan, Fauziya, Ishman, Stacey L., Mitchell, Ron B., Morrical, Michael G., Naqvi, Syed K., Radcliffe, Jerilynn, Riggan, Emily I., Rosen, Carol L., Ross, Kristie, Rueschman, Michael, Tapia, Ignacio E., Taylor, H. Gerry, Zopf, David A., and Redline, Susan

Abstract

Introduction Mild obstructive sleep-disordered breathing (oSDB), characterised by habitual snoring without frequent apnoeas and hypopnoeas on polysomnography, is prevalent in children and commonly treated with adenotonsillectomy (AT). However, the absence of high-level evidence addressing the role of AT in improving health and behavioural outcomes has contributed to significant geographical variations in care and potential for surgery to be both overused and underused. Methods and analysis The Pediatric Adenotonsillectomy Trial for Snoring (PATS) is a single-blinded, multicentre randomised controlled trial designed to evaluate the effect of AT in treating mild oSDB. Four hundred sixty eligible children, aged 3.0–12.9 years old, will be randomised to either early adenotonsillectomy or to watchful waiting with supportive care (WWSC) with a 1:1 ratio. The study’s coprimary endpoints are (1) change from baseline in executive behaviour relating to self-regulation and organisation skills as measured by the Behavioural Rating Inventory of Executive Function (BRIEF) Global Composite Score (GEC); and (2) change from baseline in vigilance as measured on the Go-No- Go (GNG) signal detection parameter (d-prime). A mixed effects model will be used to compare changes in the BRIEF GEC score and GNG score at 6 and 12 months from baseline between the AT arm and the WWSC arm. Ethics and dissemination The study protocol was approved by the institutional review board (IRB) at Children’s Hospital of Philadelphia (CHOP) on 3 October 2014 (14–0 11 214). The approval of CHOP as the central IRB of record was granted on 29 February 2016. The results will be published in peer-reviewed journals and presented at academic conferences. The data collected from the PATS study will be deposited in a repository (National Sleep Research Resource, sleepdata. org) after completion of the study to maximise use by the scientific community. [ABSTRACT FROM AUTHOR]

Published
2020
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28. Cognitive Effects of Adenotonsillectomy for Obstructive Sleep Apnea

Author

Taylor, H. Gerry, primary, Bowen, Susan R., additional, Beebe, Dean W., additional, Hodges, Elise, additional, Amin, Raouf, additional, Arens, Raanan, additional, Chervin, Ronald D., additional, Garetz, Susan L., additional, Katz, Eliot S., additional, Moore, Reneé H., additional, Morales, Knashawn H., additional, Muzumdar, Hiren, additional, Paruthi, Shalini, additional, Rosen, Carol L., additional, Sadhwani, Anjali, additional, Thomas, Nina Hattiangadi, additional, Ware, Janice, additional, Marcus, Carole L., additional, Ellenberg, Susan S., additional, Redline, Susan, additional, and Giordani, Bruno, additional

Published
2016
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29. Utility of Symptoms to Predict Treatment Outcomes in Obstructive Sleep Apnea Syndrome

Author

Rosen, Carol L., primary, Wang, Rui, additional, Taylor, H. Gerry, additional, Marcus, Carole L., additional, Katz, Eliot S., additional, Paruthi, Shalini, additional, Arens, Raanan, additional, Muzumdar, Hiren, additional, Garetz, Susan L., additional, Mitchell, Ron B., additional, Jones, Dwight, additional, Weng, Jia, additional, Ellenberg, Susan, additional, Redline, Susan, additional, and Chervin, Ronald D., additional

Published
2015
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30. Quality of Life and Obstructive Sleep Apnea Symptoms After Pediatric Adenotonsillectomy

Author

Garetz, Susan L., primary, Mitchell, Ron B., additional, Parker, Portia D., additional, Moore, Reneé H., additional, Rosen, Carol L., additional, Giordani, Bruno, additional, Muzumdar, Hiren, additional, Paruthi, Shalini, additional, Elden, Lisa, additional, Willging, Paul, additional, Beebe, Dean W., additional, Marcus, Carole L., additional, Chervin, Ronald D., additional, and Redline, Susan, additional

Published
2015
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31. SUBJECTIVE SLEEPINESS AND POLYSOMNOGRAPHIC CORRELATES IN CHILDREN SCHEDULED FOR ADENOTONSILLECTOMY VS. OTHER SURGICAL CARE

Author

Chervin, Ronald D., Weatherly, Robert A., Ruzicka, Deborah L., Burns, Joseph W., Giordani, Bruno J., Dillon, James E., Marcus, Carole L., Garetz, Susan L., Hoban, Timothy F., and Guire, Kenneth E.

Subjects
Male, Polysomnography, Disorders of Excessive Somnolence, Article, nervous system diseases, respiratory tract diseases, Adenoidectomy, Cross-Sectional Studies, Child, Preschool, Surgical Procedures, Operative, Surveys and Questionnaires, mental disorders, Preoperative Care, Humans, Female, cardiovascular diseases, Prospective Studies, Child, Tonsillectomy
Abstract

To compare a validated subjective measure of childhood sleepiness to an objective determination, assess the frequency of problematic sleepiness among children with suspected sleep-disordered breathing (SDB), and examine what standard or investigational polysomnographic measures of SDB predict subjective sleepiness.Prospective, cross-sectional.University-based sleep disorders laboratory.Washtenaw County Adenotonsillectomy Cohort.Polysomnography followed by Multiple Sleep Latency Tests (MSLTs) in 103 children aged 5 to 12 years old: 77 were scheduled for clinically indicated adenotonsillectomy, usually for suspected SDB, and 26 for unrelated surgical care. Parents completed the previously validated, 4-item Pediatric Sleep Questionnaire-Sleepiness Subscale (PSQ-SS).Thirty-three (43%) of the children scheduled for adenotonsillectomy had high PSQ-SS scores, in comparison with only 3 (12%) of the controls (p = .004). The PSQ-SS scores correlated inversely with mean sleep latencies on the MSLTs (rho = -0.23, p = .006). The obstructive apnea index, apnea-hypopnea index, and respiratory disturbance index (which included respiratory event-related arousals identified by esophageal pressure monitoring) each correlated similarly with PSQ-SS scores, as did investigational quantification of esophageal pressures and respiratory cycle-related electroencephalographic changes (each rho approximately 0.30, p.02). A stepwise regression identified sigma-frequency respiratory cycle-related electroencephalographic changes as the strongest independent predictor of subjective sleepiness among all subjects and particularly among those without obstructive sleep apnea.Sleepiness is a frequent problem among children with suspected SDB. Subjective sleepiness (PSQ-SS) reflects MSLT results to a limited extent, as in adults. Standard polysomnographic measures of SDB predict subjective sleepiness, but respiratory cycle-related electroencephalographic changes may offer additional clinical utility.

Published
2006

32. Do Respiratory Cycle-Related EEG Changes or Arousals from Sleep Predict Neurobehavioral Deficits and Response to Adenotonsillectomy in Children?

Author

Chervin, Ronald D., primary, Garetz, Susan L., additional, Ruzicka, Deborah L., additional, Hodges, Elise K., additional, Giordani, Bruno J., additional, Dillon, James E., additional, Felt, Barbara T., additional, Hoban, Timothy F., additional, Guire, Kenneth E., additional, O'Brien, Louise M., additional, and Burns, Joseph W., additional

Published
2014
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33. A Randomized Trial of Adenotonsillectomy for Childhood Sleep Apnea

Author

Marcus, Carole L., primary, Moore, Reneé H., additional, Rosen, Carol L., additional, Giordani, Bruno, additional, Garetz, Susan L., additional, Taylor, H. Gerry, additional, Mitchell, Ron B., additional, Amin, Raouf, additional, Katz, Eliot S., additional, Arens, Raanan, additional, Paruthi, Shalini, additional, Muzumdar, Hiren, additional, Gozal, David, additional, Thomas, Nina Hattiangadi, additional, Ware, Janice, additional, Beebe, Dean, additional, Snyder, Karen, additional, Elden, Lisa, additional, Sprecher, Rober C., additional, Willging, Paul, additional, Jones, Dwight, additional, Bent, John P., additional, Hoban, Timothy, additional, Chervin, Ronald D., additional, Ellenberg, Susan S., additional, and Redline, Susan, additional

Published
2014
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34. Predictors of poor sleep quality among head and neck cancer patients

Author

Department of Otolaryngology, Michigan, U.S.A. ; Department of Psychiatry (s.a.d.), and the School of Nursing, University of Michigan, Ann Arbor, Michigan, U.S.A. ; Veterans Affairs Center for Clinical Management Research, Health Services Research and Development, Veteran Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, U.S.A., Department of Psychiatry (s.a.d.), and the School of Nursing, University of Michigan, Ann Arbor, Michigan, U.S.A. ; Veterans Affairs Center for Clinical Management Research, Health Services Research and Development, Veteran Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, U.S.A., Department of Otolaryngology, Michigan, U.S.A. ; Department of Otolaryngology, 1904 Taubman Center, University of Michigan Hospitals, Ann Arbor, MI 48109, Department of Otolaryngology, Michigan, U.S.A., Department of Otolaryngology, Michigan, U.S.A. ; Department of Otolaryngology, Henry Ford Health System, Detroit, Michigan, U.S.A., Veterans Affairs Center for Clinical Management Research, Health Services Research and Development, Veteran Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, U.S.A., Shuman, Andrew G., Duffy, Sonia A., Ronis, David L., Garetz, Susan L., McLean, Scott A., Fowler, Karen E., Terrell, Jeffrey E., Department of Otolaryngology, Michigan, U.S.A. ; Department of Psychiatry (s.a.d.), and the School of Nursing, University of Michigan, Ann Arbor, Michigan, U.S.A. ; Veterans Affairs Center for Clinical Management Research, Health Services Research and Development, Veteran Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, U.S.A., Department of Psychiatry (s.a.d.), and the School of Nursing, University of Michigan, Ann Arbor, Michigan, U.S.A. ; Veterans Affairs Center for Clinical Management Research, Health Services Research and Development, Veteran Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, U.S.A., Department of Otolaryngology, Michigan, U.S.A. ; Department of Otolaryngology, 1904 Taubman Center, University of Michigan Hospitals, Ann Arbor, MI 48109, Department of Otolaryngology, Michigan, U.S.A., Department of Otolaryngology, Michigan, U.S.A. ; Department of Otolaryngology, Henry Ford Health System, Detroit, Michigan, U.S.A., Veterans Affairs Center for Clinical Management Research, Health Services Research and Development, Veteran Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan, U.S.A., Shuman, Andrew G., Duffy, Sonia A., Ronis, David L., Garetz, Susan L., McLean, Scott A., Fowler, Karen E., and Terrell, Jeffrey E.

Abstract

Objectives/Hypothesis: The objective of this study was to determine the predictors of sleep quality among head and neck cancer patients 1 year after diagnosis. Study Design: This was a prospective, multisite cohort study of head and neck cancer patients (N = 457). Methods: Patients were surveyed at baseline and 1 year after diagnosis. Chart audits were also conducted. The dependent variable was a self-assessed sleep score 1 year after diagnosis. The independent variables were a 1 year pain score, xerostomia, treatment received (radiation, chemotherapy, and/or surgery), presence of a feeding tube and/or tracheotomy, tumor site and stage, comorbidities, depression, smoking, problem drinking, age, and sex. Results: Both baseline (67.1) and 1-year postdiagnosis (69.3) sleep scores were slightly lower than population means (72). Multivariate analyses showed that pain, xerostomia, depression, presence of a tracheotomy tube, comorbidities, and younger age were statistically significant predictors of poor sleep 1 year after diagnosis of head and neck cancer ( P < .05). Smoking, problem drinking, and female sex were marginally significant ( P < .09). Type of treatment (surgery, radiation and/or chemotherapy), primary tumor site, and cancer stage were not significantly associated with 1-year sleep scores. Conclusions: Many factors adversely affecting sleep in head and neck cancer patients are potentially modifiable and appear to contribute to decreased quality of life. Strategies to reduce pain, xerostomia, depression, smoking, and problem drinking may be warranted, not only for their own inherent value, but also for improvement of sleep and the enhancement of quality of life. Laryngoscope, 2010

Published
2010

36. Obstructive Sleep Apnea Severity And Associated Co-Morbidities In Candidates For Adenotonsillectomy: The Childhood Adenotonsillectomy (CHAT) Study

Author

Weinstock, Tanya G., primary, Marcus, Carole L., additional, Amin, Raouf S., additional, Rosen, Carol, additional, Garetz, Susan L., additional, Mitchell, Ronald, additional, Arens, Raanan, additional, Weng, Jia, additional, Ross, Kristie, additional, Wang, Rui, additional, Ellenberg, Susan, additional, and Redline, Susan S., additional

Published
2012
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38. The Childhood Adenotonsillectomy Trial (CHAT): Rationale, Design, and Challenges of a Randomized Controlled Trial Evaluating a Standard Surgical Procedure in a Pediatric Population

Author

Redline, Susan, primary, Amin, Raouf, additional, Beebe, Dean, additional, Chervin, Ronald D., additional, Garetz, Susan L., additional, Giordani, Bruno, additional, Marcus, Carole L., additional, Moore, Renee H., additional, Rosen, Carol L., additional, Arens, Raanan, additional, Gozal, David, additional, Katz, Eliot S., additional, Mitchell, Ronald B., additional, Muzumdar, Hiren, additional, Taylor, H.G., additional, Thomas, Nina, additional, and Ellenberg, Susan, additional

Published
2011
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44. Pediatric Sleep Questionnaire

Author

Chervin, Ronald D., primary, Weatherly, Robert A., additional, Garetz, Susan L., additional, Ruzicka, Deborah L., additional, Giordani, Bruno J., additional, Hodges, Elise K., additional, Dillon, James E., additional, and Guire, Kenneth E., additional

Published
2007
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46. The Effect of Adenotonsillectomy for Childhood Sleep Apnea on Cardiometabolic Measures.

Author

Quante, Mirja, Wang, Rui, Weng, Jia, Rosen, Carol L, Amin, Raouf, Garetz, Susan L, Katz, Eliot, Paruthi, Shalini, Arens, Raanan, Muzumdar, Hiren, Marcus, Carole L, Ellenberg, Susan, and Redline, Susan

Abstract

Obstructive sleep apnea syndrome (OSAS) has been associated with cardiometabolic disease in adults. In children, this association is unclear. We evaluated the effect of early adenotonsillectomy (eAT) for treatment of OSAS on blood pressure, heart rate, lipids, glucose, insulin, and C-reactive protein. We also analyzed whether these parameters at baseline and changes at follow-up correlated with polysomnographic indices.

Published
2015
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49. A model to facilitate outcome assessment of obstructive sleep apnea.

Author

Sonnad, Seems S, Moyer, Cheryl A, Patel, Shushma, Helman, Joseph I, Garetz, Susan L, and Chervin, Ronald D

Abstract

Objectives: Obstructive sleep apnea is a common disorder with significant morbidity and effects on quality of life. Management can include a range of mechanical, behavioral, and surgical approaches. This paper aims to devise a model of management options to assist in initial cost-effectiveness investigations.Methods: In the absence of practice pattern data and widely accepted guidelines, we reviewed published literature and devised a model of treatment options to facilitate initial studies of outcomes, costs, and cost-effectiveness.Results: Obstructive sleep apnea is rarely addressed by conservative behavioral-based strategies because these options, while inexpensive, have only limited effectiveness. Effective treatment most often relies on nasal continuous positive airway pressure, but poor tolerance or compliance sometimes leads to treatment with oral appliances or surgery. Patients treated by one modality may try another if the initial strategy is ineffective. Laboratory evidence that sleep apnea is effectively treated, and long-term follow-up, are necessary regardless of the treatment modality chosen.Conclusions: Each patient's treatment plan must be individually tailored, but the management model proposed here reflects available evidence-based literature and the authors' impression of current practice patterns. This model should be useful for initial cost-effectiveness investigations. [ABSTRACT FROM AUTHOR]

Published
2003
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50. INVITED EDITORIAL: A Case for Increased Research on the Pediatric Upper Airway.

Author

GARETZ, SUSAN L.

Subjects
*AIRWAY (Anatomy), *PEDIATRICS, *RESPIRATION, *DIAGNOSTIC imaging
Abstract

The article focuses on the report "Developmental Aspects of the Upper Airway: Report From an NHLBI Workshop March 5-6,2009," published by National Heart Lung and Blood Institute. It identified three categories relating to the pediatric upper airway, where there is a need to research further, these include craniofacial and laryngotracheal airway development, development of upper airway neuromotor control, and evaluation of the upper airway using imaging and other techniques.

Published
2009
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